{"id":166,"date":"2019-10-17T22:05:57","date_gmt":"2019-10-17T22:05:57","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/chapter\/4-9-alpha-1-antagonists\/"},"modified":"2025-01-16T22:25:49","modified_gmt":"2025-01-16T22:25:49","slug":"4-9-alpha-1-antagonists","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/chapter\/4-9-alpha-1-antagonists\/","title":{"raw":"4.9 Alpha-1 Antagonists","rendered":"4.9 Alpha-1 Antagonists"},"content":{"raw":"Tamsulosin is an Alpha-1 antagonist.\n\nMechanism of Action:<\/strong> Tamsulosin selectively blocks alpha-receptors in the prostate, leading to the relaxation of smooth muscles in the bladder, neck, and prostate, thus improving urine flow and reducing symptoms of benign prostatic hypertrophy (BPH).\n\nIndications:<\/strong> Tamsulosin is used to treat BPH.\n\nNursing Considerations:<\/strong> Avoid using with other alpha-blockers. Tamsulosin is contraindicated with strong CYP3A4 inhibitors such as ketoconazole. Assess and monitor blood pressure, especially after first dose because tamsulosin may cause orthostatic hypotension.\n\nSide Effects\/Adverse Effects: <\/strong>Alpha-1 antagonists may result in hypotension, weakness, and dizziness.\n\nHealth Teaching & Health Promotion:<\/strong>\u00a0Advise clients to change positions slowly because the drug may cause orthostatic blood pressure changes. Additionally, the client should take the medication at the same time each day. The client should follow up with their health care provider to assess the effectiveness of the medication.[footnote]uCentral from Unbound Medicine. https:\/\/www.unboundmedicine.com\/ucentral<\/a>[\/footnote]<\/sup>\n\nNow let's take a closer look at the medication grid on tamsulosin in Table 4.9.[footnote]This work is a derivative of DailyMed<\/a> by U.S. National Library of Medicine<\/a> in the Public Domain<\/a>.[\/footnote]<\/sup>\n\nTable 4.9 Tamsulosin Medication Grid\n\n\n\n\n
\n
Class\/Subclass<\/strong><\/h5>\n<\/th>\n
\n
Prototype\/Generic<\/strong><\/h5>\n<\/th>\n
\n
Nursing Considerations<\/strong><\/h5>\n<\/th>\n
\n
Therapeutic Effects<\/strong><\/h5>\n<\/th>\n
\n
Side\/Adverse Effects<\/strong><\/h5>\n<\/th>\n<\/tr>\n
Alpha-1 Antagonist<\/th>\ntamsulosin<\/a><\/td>\nAvoid using with other alpha-blockers\n\nAssess and monitor orthostatic blood pressure, especially after first dose<\/td>\nRelaxes smooth muscle in bladder\/prostate to improve urine flow<\/td>\nHypotension, especially after first dose. Advise client to change positions slowly<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n ","rendered":"

Tamsulosin is an Alpha-1 antagonist.<\/p>\n

Mechanism of Action:<\/strong> Tamsulosin selectively blocks alpha-receptors in the prostate, leading to the relaxation of smooth muscles in the bladder, neck, and prostate, thus improving urine flow and reducing symptoms of benign prostatic hypertrophy (BPH).<\/p>\n

Indications:<\/strong> Tamsulosin is used to treat BPH.<\/p>\n

Nursing Considerations:<\/strong> Avoid using with other alpha-blockers. Tamsulosin is contraindicated with strong CYP3A4 inhibitors such as ketoconazole. Assess and monitor blood pressure, especially after first dose because tamsulosin may cause orthostatic hypotension.<\/p>\n

Side Effects\/Adverse Effects: <\/strong>Alpha-1 antagonists may result in hypotension, weakness, and dizziness.<\/p>\n

Health Teaching & Health Promotion:<\/strong>\u00a0Advise clients to change positions slowly because the drug may cause orthostatic blood pressure changes. Additionally, the client should take the medication at the same time each day. The client should follow up with their health care provider to assess the effectiveness of the medication.[1]<\/sup><\/a><\/sup><\/p>\n

Now let’s take a closer look at the medication grid on tamsulosin in Table 4.9.[2]<\/sup><\/a><\/sup><\/p>\n

Table 4.9 Tamsulosin Medication Grid<\/p>\n\n\n\n\n
\n
Class\/Subclass<\/strong><\/h5>\n<\/th>\n
\n
Prototype\/Generic<\/strong><\/h5>\n<\/th>\n
\n
Nursing Considerations<\/strong><\/h5>\n<\/th>\n
\n
Therapeutic Effects<\/strong><\/h5>\n<\/th>\n
\n
Side\/Adverse Effects<\/strong><\/h5>\n<\/th>\n<\/tr>\n
Alpha-1 Antagonist<\/th>\ntamsulosin<\/a><\/td>\nAvoid using with other alpha-blockers<\/p>\n

Assess and monitor orthostatic blood pressure, especially after first dose<\/td>\n

Relaxes smooth muscle in bladder\/prostate to improve urine flow<\/td>\nHypotension, especially after first dose. Advise client to change positions slowly<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

  1. uCentral from Unbound Medicine. https:\/\/www.unboundmedicine.com\/ucentral<\/a> ↵<\/a><\/li>
  2. This work is a derivative of DailyMed<\/a> by U.S. National Library of Medicine<\/a> in the Public Domain<\/a>. ↵<\/a><\/li><\/ol><\/div>","protected":false},"author":83,"menu_order":9,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[48],"contributor":[],"license":[],"class_list":["post-166","chapter","type-chapter","status-publish","hentry","chapter-type-numberless"],"part":140,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters\/166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/users\/83"}],"version-history":[{"count":1,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters\/166\/revisions"}],"predecessor-version":[{"id":167,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters\/166\/revisions\/167"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/parts\/140"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters\/166\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/media?parent=166"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapter-type?post=166"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/contributor?post=166"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/license?post=166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}