{"id":160,"date":"2019-10-17T19:31:13","date_gmt":"2019-10-17T19:31:13","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/chapter\/4-6-muscarinic-receptor-agonist\/"},"modified":"2025-01-16T22:25:49","modified_gmt":"2025-01-16T22:25:49","slug":"4-6-muscarinic-receptor-agonist","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/chapter\/4-6-muscarinic-receptor-agonist\/","title":{"raw":"4.6 Muscarinic Receptor Agonists","rendered":"4.6 Muscarinic Receptor Agonists"},"content":{"raw":"Pilocarpine is a muscarinic receptor agonist.\n\nMechanism of Action:<\/strong> Pilocarpine causes the ciliary muscle to contract, allowing for the drainage of aqueous humor from the anterior chamber of the eye, thus reducing intraocular pressure related to glaucoma.\n\nIndications:<\/strong> Pilocarpine is used to treat glaucoma.\n\nNursing Considerations:<\/strong> Apply light finger pressure on lacrimal sac for 2 minutes after instilling to minimize systemic absorption. Remove contact lens before administration.\n\nSide Effects\/Adverse Effects: <\/strong>Adverse effects of muscarinic (cholinergic) agonists can be memorized using the mnemonic \"DUMBBELSS\" reflecting D<\/strong><\/span>iarrhea, U<\/strong><\/span>rination, M<\/strong><\/span>iosis (constriction of the pupil of the eye), B<\/strong><\/span>ronchospasm, B<\/span><\/strong>radycardia, E<\/strong><\/span>xcitation of the skeletal muscle and CNS, L<\/strong><\/span>acrimation, S<\/strong><\/span>weating, and S<\/strong><\/span>alivation.\n\nHealth Teaching & Health Promotion:<\/strong> Advise the client to use caution with night driving. Additionally, use of this medication can cause hypotension.[footnote]uCentral from Unbound Medicine. https:\/\/www.unboundmedicine.com\/ucentral<\/a>[\/footnote]<\/sup>\n\nNow let's take a closer look at the medication grid on pilocarpine in Table 4.6.[footnote]This work is a derivative of DailyMed<\/a> by U.S. National Library of Medicine<\/a> in the Public Domain<\/a>.[\/footnote]<\/sup>\n\nTable 4.6 Pilocarpine Medication Grid\n\n\n\n\n
\n
Class\/Subclass<\/strong><\/h5>\n<\/th>\n
\n
Prototype\/Generic<\/strong><\/h5>\n<\/th>\n
\n
Nursing Considerations<\/strong><\/h5>\n<\/th>\n
\n
Therapeutic Effects<\/strong><\/h5>\n<\/th>\n
\n
Side\/Adverse Effects<\/strong><\/h5>\n<\/th>\n<\/tr>\n
Muscarinic Agonist<\/strong><\/td>\npilocarpine<\/a><\/td>\nApply light finger pressure on lacrimal sac for 2 minutes after instilling to minimize systemic absorption. Remove contact lens before administration<\/td>\nControls intraocular pressure in glaucoma<\/td>\nIndividuals should use caution with night driving\n\nIndividuals may experience light-headedness, bronchospasm, nausea, vomiting, stomach cramps, diarrhea, sweating, lacrimation, and salivation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n ","rendered":"

Pilocarpine is a muscarinic receptor agonist.<\/p>\n

Mechanism of Action:<\/strong> Pilocarpine causes the ciliary muscle to contract, allowing for the drainage of aqueous humor from the anterior chamber of the eye, thus reducing intraocular pressure related to glaucoma.<\/p>\n

Indications:<\/strong> Pilocarpine is used to treat glaucoma.<\/p>\n

Nursing Considerations:<\/strong> Apply light finger pressure on lacrimal sac for 2 minutes after instilling to minimize systemic absorption. Remove contact lens before administration.<\/p>\n

Side Effects\/Adverse Effects: <\/strong>Adverse effects of muscarinic (cholinergic) agonists can be memorized using the mnemonic “DUMBBELSS” reflecting D<\/strong><\/span>iarrhea, U<\/strong><\/span>rination, M<\/strong><\/span>iosis (constriction of the pupil of the eye), B<\/strong><\/span>ronchospasm, B<\/span><\/strong>radycardia, E<\/strong><\/span>xcitation of the skeletal muscle and CNS, L<\/strong><\/span>acrimation, S<\/strong><\/span>weating, and S<\/strong><\/span>alivation.<\/p>\n

Health Teaching & Health Promotion:<\/strong> Advise the client to use caution with night driving. Additionally, use of this medication can cause hypotension.[1]<\/sup><\/a><\/sup><\/p>\n

Now let’s take a closer look at the medication grid on pilocarpine in Table 4.6.[2]<\/sup><\/a><\/sup><\/p>\n

Table 4.6 Pilocarpine Medication Grid<\/p>\n\n\n\n\n
\n
Class\/Subclass<\/strong><\/h5>\n<\/th>\n
\n
Prototype\/Generic<\/strong><\/h5>\n<\/th>\n
\n
Nursing Considerations<\/strong><\/h5>\n<\/th>\n
\n
Therapeutic Effects<\/strong><\/h5>\n<\/th>\n
\n
Side\/Adverse Effects<\/strong><\/h5>\n<\/th>\n<\/tr>\n
Muscarinic Agonist<\/strong><\/td>\npilocarpine<\/a><\/td>\nApply light finger pressure on lacrimal sac for 2 minutes after instilling to minimize systemic absorption. Remove contact lens before administration<\/td>\nControls intraocular pressure in glaucoma<\/td>\nIndividuals should use caution with night driving<\/p>\n

Individuals may experience light-headedness, bronchospasm, nausea, vomiting, stomach cramps, diarrhea, sweating, lacrimation, and salivation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

  1. uCentral from Unbound Medicine. https:\/\/www.unboundmedicine.com\/ucentral<\/a> ↵<\/a><\/li>
  2. This work is a derivative of DailyMed<\/a> by U.S. National Library of Medicine<\/a> in the Public Domain<\/a>. ↵<\/a><\/li><\/ol><\/div>","protected":false},"author":83,"menu_order":6,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[48],"contributor":[],"license":[],"class_list":["post-160","chapter","type-chapter","status-publish","hentry","chapter-type-numberless"],"part":140,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters\/160","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/users\/83"}],"version-history":[{"count":1,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters\/160\/revisions"}],"predecessor-version":[{"id":161,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters\/160\/revisions\/161"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/parts\/140"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapters\/160\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/media?parent=160"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/pressbooks\/v2\/chapter-type?post=160"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/contributor?post=160"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/accnursingpharmacology\/wp-json\/wp\/v2\/license?post=160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}