{"id":4935,"date":"2019-06-24T16:26:24","date_gmt":"2019-06-24T16:26:24","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/13-3-divisions-of-the-skeletal-system-3\/"},"modified":"2023-11-30T18:56:36","modified_gmt":"2023-11-30T18:56:36","slug":"13-3-divisions-of-the-skeletal-system-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/13-3-divisions-of-the-skeletal-system-3\/","title":{"raw":"11.3\u00a0Divisions of the Skeletal System","rendered":"11.3\u00a0Divisions of the Skeletal System"},"content":{"raw":"&nbsp;\r\n\r\n[caption id=\"attachment_3974\" align=\"aligncenter\" width=\"400\"]<img class=\"wp-image-3974\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Human_skulls_on_display-2.jpg\" alt=\"11.3 Skulls on Display\" width=\"400\" height=\"266\" \/> <em>11.3.1 Skulls on display.<\/em>[\/caption]\r\n\r\n<div>\r\n<h1>Skulls on Display<\/h1>\r\n<\/div>\r\nThis somewhat macabre display (Figure 11.3.1) can be viewed at the Slovak National Museum in Bratislava, Slovakia. The [pb_glossary id=\"3957\"]skulls[\/pb_glossary] are meant to represent normal human skeletal anatomy. The skull is part of the [pb_glossary id=\"3953\"]axial skeleton[\/pb_glossary], which is one of the two major divisions of the human skeleton. The other division is the [pb_glossary id=\"3954\"]appendicular skeleton[\/pb_glossary].\r\n<div>\r\n<h1>Axial Skeleton<\/h1>\r\n<\/div>\r\n\r\n[caption id=\"attachment_3955\" align=\"alignright\" width=\"429\"]<img class=\"wp-image-3955 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Axial_skeleton_diagram_blank.svg_-2.png\" alt=\"11.2 &amp; 11.3 Axial Skeleton\" width=\"429\" height=\"615\" \/> <em>Figure 11.3.2 The axial skeleton.<\/em>[\/caption]\r\n\r\nThe\u00a0<strong>[pb_glossary id=\"3953\"]axial skeleton[\/pb_glossary],<\/strong> shown in blue in Figure 11.3.2, consists of a total of 80 bones. Besides the skull, it includes the rib cage and vertebral column. It also includes the three tiny ossicles (hammer, anvil, and stirrup) in the middle ear and the hyoid bone in the throat, to which the tongue and some other soft tissues are attached.\r\n<h2>Skull<\/h2>\r\nThe\u00a0<strong>[pb_glossary id=\"3957\"]skull[\/pb_glossary]<\/strong> is the part of the human skeleton that provides a bony framework for the head. It consists of 22 different bones. There are eight bones in the cranium, which encloses the brain, and 14 bones in the face.\r\n<h3>Cranium<\/h3>\r\nThe\u00a0<strong>[pb_glossary id=\"3975\"]cranium[\/pb_glossary]\u00a0<\/strong>forms the entire upper portion of the skull. As shown in Figure 11.3.3, it consists of eight bones: one frontal bone, two parietal bones, two temporal bones, one occipital bone, one sphenoid bone, and one ethmoid bone. The ethmoid bone separates the nasal cavity from the brain. The sphenoid bone is one of several bones, including the frontal bone, that help form the eye sockets. The other bones of the cranium are large and plate-like. They cover and protect the brain. The bottom of the skull has openings for major blood vessels and nerves. A large opening, called the foramen, connects the spinal cord and brain.\r\n\r\n[caption id=\"attachment_3976\" align=\"aligncenter\" width=\"426\"]<img class=\"wp-image-3976\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/822px-Cranial_bones_en_v2.svg_-2.png\" alt=\"11.3.3 Cranial Bones\" width=\"426\" height=\"308\" \/> <em>Figure 11.3.3 The cranium consists of eight bones that are fused together at their joints.<\/em>[\/caption]\r\n<h3>Facial Bones<\/h3>\r\nThe 14 facial bones of the skull are located below the frontal bone of the cranium, and they are depicted in Figure 11.3.4. Large bones in the face include the upper jaw bones, or <strong>maxillae (singular, maxilla),<\/strong>\u00a0which form the middle part of the face and the bottom of the two eye sockets. The maxillae are fused together, except for an opening between them for the nose. The lower edge of the maxillae contains sockets for the upper teeth. The lower jaw bone, or\u00a0<strong>mandible,<\/strong> is also large. The top edge of the mandible contains sockets for the lower teeth. The mandible opens and closes to chew food and is controlled by strong muscles. There are two zygomatic (or cheek) bones and two nasal bones. The nasal region also contains seven smaller bones, as indicated in Figure 11.3.4.\r\n\r\n[caption id=\"attachment_3978\" align=\"aligncenter\" width=\"548\"]<img class=\"wp-image-3978\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Facial_skeleton_-_en.svg_-2.png\" alt=\"11.3.4 Facial Bones\" width=\"548\" height=\"481\" \/> <em>Figure 11.3.4 The 14 bones that make up the face are labeled in this drawing of the skull.<\/em>[\/caption]\r\n<h2>Vertebral Column<\/h2>\r\n[caption id=\"attachment_4000\" align=\"alignleft\" width=\"313\"]<img class=\"wp-image-4000\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Spinal_column_curvature-2.png\" alt=\"11.3.5 Vertebral Column\" width=\"313\" height=\"486\" \/> <em>Figure 11.3.5 The vertebral column consists of 24 individual vertebrae that are separated by intervertebral discs of cartilage. An additional nine vertebrae are fused together at the base of the spine. Note the S-shaped curve of the vertebral column in the profile view on the right.<\/em>[\/caption]\r\n\r\nThe\u00a0<strong>[pb_glossary id=\"3958\"]vertebral column[\/pb_glossary]<\/strong>\u00a0\u2014 also called the spine or backbone \u2014 is the flexible column of\u00a0<strong>[pb_glossary id=\"3964\"]vertebrae[\/pb_glossary] (singular, vertebra)<\/strong> that connects the trunk with the [pb_glossary id=\"3957\"]skull[\/pb_glossary] and encloses the spinal cord. It consists of 33 vertebrae that are divided into five regions, as shown in Figure 11.3.5: the [pb_glossary id=\"3979\"]cervical[\/pb_glossary], [pb_glossary id=\"5491\"]thoracic[\/pb_glossary], [pb_glossary id=\"3998\"]lumbar[\/pb_glossary], [pb_glossary id=\"3999\"]sacral[\/pb_glossary], and [pb_glossary id=\"6453\"]coccygeal[\/pb_glossary] regions. From the neck down, the first 24 vertebrae (cervical, thoracic, and lumbar) are individual bones. The five sacral vertebrae are fused together, as are the four coccygeal vertebrae.\r\n\r\n<span style=\"text-align: initial; font-size: 1em;\">The vertebral column consists of 24 individual vertebrae that are separated by [pb_glossary id=\"4001\"]intervertebral disc[\/pb_glossary]s of cartilage. An additional nine vertebrae are fused together at the base of the spine. Note the S-shaped curve of the vertebral column in the profile view in Figure 11.3.5 on the left.<\/span>\r\n\r\nThe human vertebral column reflects adaptations for upright bipedal locomotion (walking upright on two legs). For example, the vertebral column is less like a rigid column than an S-shaped spring (see profile view in Figure 11.3.5). Although newborn infants have a relatively straight spine, the curves develop as the backbone starts taking on its support functions, such as keeping the trunk erect, holding up the head, and helping to anchor the limbs. The S shape of the vertebral column allows it to act like a shock absorber, absorbing much of the jarring of walking and running so the forces are not transmitted directly from the pelvis to the skull. The S shape also helps protect the spine from breaking, which would be more likely with a straight, more rigid vertebral column. In addition, the S shape helps to distribute the weight of the body \u2014 particularly of the internal organs, so the weight load is not all at the bottom, as would occur with a straight spine.\r\n<h2>Rib Cage<\/h2>\r\nThe\u00a0<strong>[pb_glossary id=\"4002\"]rib cage[\/pb_glossary]<\/strong> (also called thoracic cage) is aptly named, because it forms a sort of cage that holds within it the organs of the upper part of the trunk, including the [pb_glossary id=\"2987\"]heart[\/pb_glossary] and [pb_glossary id=\"2990\"]lungs[\/pb_glossary]. It is shown in Figures 11.3.6\u201311.3.8. The rib cage includes the 12 thoracic vertebrae and the sternum, as well as 12 pairs of ribs, which are attached at joints to the vertebrae. The ribs are divided into three groups, called true ribs, false ribs, and floating ribs. The top seven pairs of ribs are true ribs. They are attached by cartilage directly to the sternum. The next three pairs of ribs are false ribs. They are attached by cartilage to the ribs above them, rather than directly to the sternum. The lowest two pairs of ribs are floating ribs. They are attached by cartilage to muscles in the abdominal wall. The attachments of false and floating ribs let the lower part of the rib cage expand to accommodate the internal movements of breathing.\r\n<table class=\"no-lines\" style=\"border-collapse: collapse; width: 100%; height: 206px;\" border=\"0\">\r\n<tbody>\r\n<tr>\r\n<td style=\"width: 33.3333%;\">\r\n\r\n[caption id=\"attachment_4003\" align=\"aligncenter\" width=\"213\"]<img class=\"wp-image-4003\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/True_ribs_animation-2.gif\" alt=\"11.3.6 True Ribs\" width=\"213\" height=\"213\" \/> <em>Figure 11.3.6 True ribs are attached to both the vertebrae and the sternum.\u00a0 In this image, true ribs are highlighted in red.<\/em>[\/caption]<\/td>\r\n<td style=\"width: 33.3333%;\">\r\n\r\n[caption id=\"attachment_4004\" align=\"aligncenter\" width=\"214\"]<img class=\"wp-image-4004\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/False_ribs_animation-2.gif\" alt=\"11.3.7 False Ribs\" width=\"214\" height=\"214\" \/> <em>Figure 11.3.7 False ribs are attached to the vertebrae and to the ribs above them by cartilage.\u00a0 In this image, false ribs and floating ribs are highlighted in red.<\/em>[\/caption]<\/td>\r\n<td style=\"width: 33.3333%;\">\r\n\r\n[caption id=\"attachment_4005\" align=\"aligncenter\" width=\"222\"]<img class=\"wp-image-4005\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Floating_ribs_animation-2.gif\" alt=\"11.3.8 Floating Ribs\" width=\"222\" height=\"222\" \/> <em>Figure 11.3.8 Floating ribs are attached to vertebrae and the the muscles in the abdominal wall. In this image floating ribs are highlighted in red.<\/em>[\/caption]<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<div>\r\n\r\n<span style=\"font-size: 1.602em; font-weight: bold;\">Appendicular Skeleton<\/span>\r\n\r\n<\/div>\r\nThe\u00a0<strong>[pb_glossary id=\"3954\"]appendicular skeleton[\/pb_glossary],<\/strong> shown in red (Figure 11.3.9), consists of a total of 126 bones. It includes all the bones of the limbs (arms, legs, hands, and feet,) as well as the bones of the shoulder (shoulder girdle) and pelvis (pelvic girdle).\r\n\r\n[caption id=\"attachment_4006\" align=\"aligncenter\" width=\"373\"]<img class=\"wp-image-4006\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Appendicular_skeleton_diagram.svg_-2.png\" alt=\"11.3.9 Appendicular Skeleton\" width=\"373\" height=\"690\" \/> <em>Figure 11.3.9 The appendicular skeleton includes the upper and lower appendages and girdles.<\/em>[\/caption]\r\n<h2>Upper Limbs<\/h2>\r\nEach upper limb consists of 30 bones. As shown in Figure 11.3.10, there is one bone (called the humerus) in each of the upper arms, and there are two bones (called the ulna and radius) in each of the lower arms. The remaining bones of the upper limb are shown in Figure 11.3.11. Each wrist contains eight carpal bones \u2014 which are arranged in two rows of four bones each \u2014 and each hand contains five metacarpal bones. The bones in the fingers of each hand include 14 phalanges (three in each finger except the thumb, which has two phalanges). The thumb has the unique ability to move into opposition with the palm of the hand, and with each of the fingers when they are slightly bent. This allows the hand to handle and manipulate objects such as tools.\r\n\r\n[caption id=\"attachment_4007\" align=\"alignright\" width=\"185\"]<img class=\"wp-image-4007\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Humerus_ulna_and_radius_female-2.png\" alt=\"11.3.10 Bones of the Arm\" width=\"185\" height=\"318\" \/> Figure 11.3.10 The arm consists of three bones: the humerus, radius and ulna.[\/caption]\r\n\r\n[caption id=\"attachment_4008\" align=\"alignnone\" width=\"400\"]<img class=\"wp-image-4008\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Human_left_hand_bones_with_metacarpal_numbers_and_carpal_letters.svg_-2.png\" alt=\"11.3.11 Bones of the hand\" width=\"400\" height=\"327\" \/> Figure 11.3.11 Bones of the wrist (carpals A-E) and hand (metacarpals 1-5 and phalanges).[\/caption]\r\n<h2>Lower Limbs<\/h2>\r\n[caption id=\"attachment_4009\" align=\"alignleft\" width=\"236\"]<img class=\"wp-image-4009\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Human_leg_bones_labeled.svg_-2.png\" alt=\"11.3.12 Bones of the Legs\" width=\"236\" height=\"357\" \/> <em>Figure 11.3.12 Bones of the legs.<\/em>[\/caption]\r\n\r\nEach lower limb consists of 30 bones. As shown in Figure 11.3.12 to the left, there is one bone (called the femur) in each of the upper legs, and there are two bones (called the tibia and fibula) in each of the lower legs. The knee cap (or patella) is an additional leg bone at the front of each knee, which is the largest joint in the human body.\r\n\r\n[caption id=\"attachment_4010\" align=\"alignright\" width=\"233\"]<img class=\"wp-image-4010\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0411_FootAnatomy-2.png\" alt=\"11.3.13 Bones of the foot\" width=\"233\" height=\"466\" \/> <em>Figure 11.3.13 Bones of the lower leg (fibula and tibia), ankle (talus), heel (calcaneus), foot (metatarsals), and toes (phalanges).<\/em>[\/caption]\r\n\r\nThe remaining bones of the lower limbs are in Figure 11.3.13 to the right. Each ankle contains seven tarsal bones (including the talus and calcaneus), and each foot contains five metatarsal bones. The tarsals and metatarsals form the ankle, heel, and arch of the foot. They give the foot strength while allowing flexibility. The bones in the toes of each foot consist of 14 phalanges (three in each toe except the big toe, which has two phalanges)\r\n\r\n<span style=\"text-align: initial; font-size: 1em;\">Bones of the lower leg (fibula and tibia), ankle (talus), heel (calcaneus), foot (metatarsals), and toes (phalanges)<\/span>\r\n<h2>Shoulder Girdle<\/h2>\r\nThe\u00a0<strong>[pb_glossary id=\"4012\"]pectoral girdle[\/pb_glossary]<\/strong> (also called shoulder girdle) attaches the upper limbs to the trunk of the body. It is connected to the [pb_glossary id=\"3953\"]axial skeleton[\/pb_glossary] by muscles alone. This allows a considerable range of motion in the upper limbs. The shoulder girdle consists of just two pairs of bones, with one of each pair on opposite sides of the body (see Figure 11.3.14). There are a right and left clavicle (collarbone), and a right and left scapula (shoulder blade). The scapula is a pear-shaped flat bone that helps form the shoulder joint. The clavicle is a long bone that serves as a strut between the shoulder blade and the sternum.\r\n\r\n[caption id=\"attachment_4013\" align=\"aligncenter\" width=\"428\"]<img class=\"wp-image-4013\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Pectoral_girdle_front_diagram.svg_-2.png\" alt=\"11.3.14 Bones of the Shoulder Girdle\" width=\"428\" height=\"336\" \/> <em>Figure 11.3.14 Bones of the shoulder girdle.<\/em>[\/caption]\r\n\r\n<div>\r\n\r\n<span style=\"font-size: 1.424em; font-weight: bold;\">Pelvic Girdle<\/span>\r\n\r\n<\/div>\r\n\r\n[caption id=\"attachment_4014\" align=\"alignright\" width=\"446\"]<img class=\"wp-image-4014\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2048px-Blausen_0723_Pelvis-2.png\" alt=\"11.3.15 Bones of the Pelvic Girdle\" width=\"446\" height=\"446\" \/> <em>Figure 11.3.15 Bones of the pelvic girdle.<\/em>[\/caption]\r\n\r\nThe\u00a0<strong>[pb_glossary id=\"3963\"]pelvic girdle[\/pb_glossary]<\/strong> attaches the legs to the trunk of the body, and also provides a basin to contain and support the organs of the abdomen. It is connected to the vertebral column of the axial skeleton by ligaments. The pelvic girdle consists of two halves \u2014 one half for each leg \u2014 but the halves are fused with each other in adults at a joint called the pubic symphysis. Each half of the pelvic girdle includes three bones, as shown in Figure 11.3.15 to the right: the ilium (flaring upper part of the pelvic girdle), pubis (lower front), and ischium (lower back). Each of these bones helps form the acetabulum, which is a depression into which the top of the femur (thighbone) fits. When the body is in a seated position, it rests on protrusions (called tuberosities) of the two ischial bones.\r\n<div>\r\n\r\n&nbsp;\r\n\r\n<\/div>\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">11.3 Summary<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul>\r\n \t<li>The [pb_glossary id=\"3953\"]axial skeleton[\/pb_glossary] consists of a total of 80 bones. It includes the skull, vertebral column, and rib cage. It also includes the three tiny ossicles in the middle ear and the hyoid bone in the throat.<\/li>\r\n \t<li>The [pb_glossary id=\"3957\"]skull[\/pb_glossary] provides a bony framework for the head. It consists of 22 different bones:\u00a0eight\u00a0in the [pb_glossary id=\"3975\"]cranium[\/pb_glossary] (which encloses the brain) and 14 in the face (which includes the upper and lower jaw).<\/li>\r\n \t<li>The [pb_glossary id=\"3958\"]vertebral column[\/pb_glossary] is a flexible, S-shaped column of 33 vertebrae that connects the trunk with the skull and encloses the spinal cord. The vertebrae are divided into five regions: cervical, thoracic, lumbar, sacral, and coccygeal regions. The S shape of the vertebral column allows it to absorb shocks and distribute the weight of the body.<\/li>\r\n \t<li>The rib cage holds and protects the organs of the upper part of the trunk, including the heart and lungs. It includes the 12 thoracic vertebrae, the sternum, and 12 pairs of ribs.<\/li>\r\n \t<li>The [pb_glossary id=\"3954\"]appendicular skeleton[\/pb_glossary] consists of a total of 126 bones. It includes the bones of the four limbs, shoulder girdle, and pelvic girdle.<\/li>\r\n \t<li>Each upper limb consists of 30 bones. There is one bone (called the humerus) in the upper arm, and two bones (called the ulna and radius) in the lower arm. The wrist contains\u00a0eight\u00a0carpal bones, the hand contains\u00a0five\u00a0metacarpals, and the fingers consist of 14 phalanges. The thumb is opposable to the palm and fingers of the same hand.<\/li>\r\n \t<li>Each lower limb also consists of 30 bones. There is one bone (called the femur) in the upper leg, and two bones (called the tibia and fibula) in the lower leg. The patella covers the knee joint. The ankle contains\u00a0seven\u00a0tarsal bones, and the foot contains\u00a0five\u00a0metatarsals. The tarsals and metatarsals form the heel and arch of the foot. The bones in the toes consist of 14 phalanges.<\/li>\r\n \t<li>The shoulder girdle attaches the upper limbs to the trunk of the body. It is connected to the axial skeleton only by muscles, allowing mobility of the upper limbs. Bones of the shoulder girdle include a right and left clavicle, as well as a right and left scapula.<\/li>\r\n \t<li>The pelvic girdle attaches the legs to the trunk of the body, and supports the organs of the abdomen. It is connected to the axial skeleton by ligaments. The pelvic girdle consists of two halves that are fused together in adults. Each half consists of three bones: the ilium, pubis, and ischium.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">11.3 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ol>\r\n \t<li>[h5p id=\"593\"]<\/li>\r\n \t<li>[h5p id=\"594\"]<\/li>\r\n \t<li>What are the advantages of an S-shaped vertebral column?<\/li>\r\n \t<li>What is the rib cage? What is its function?\u00a0 What types of ribs are there?<\/li>\r\n \t<li>Explain the advantage of having some ribs that are not attached directly to the sternum.<\/li>\r\n \t<li>What is the shoulder girdle? Why does it allow considerable upper limb mobility?<\/li>\r\n \t<li>Describe some of the similarities between the upper limbs and the lower limbs.<\/li>\r\n \t<li>Describe the pelvic girdle and the bones it contains.<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">11.3 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=WRmNC_yPQZ8\r\n<p style=\"text-align: center;\">Bones of the skull - Learn in 4 minutes! Neural Academy, 2018.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=fcHB2pvH2uc\r\n<p style=\"text-align: center;\">Craniosynostosis - Mayo Clinic, 2011.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n&nbsp;\r\n<h2>Attributions<\/h2>\r\n<strong>Figure 11.3.1<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Human_skulls_on_display.JPG\" rel=\"cc:attributionURL\">Human_skulls_on_display<\/a> by <a title=\"User:Kiwiev\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kiwiev\">Kiwiev<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) license.\r\n\r\n<strong style=\"text-align: initial; font-size: 1em;\">\r\nFigure 11.3.2<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Axial_skeleton_diagram_blank.svg\" rel=\"cc:attributionURL\">Axial_skeleton_diagram_blank.svg<\/a> by <a title=\"User:Qllach\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Qllach\">Quico\/ <\/a><a title=\"User:Qllach\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Qllach\">Qllach<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain). (This is a derivative work<b><\/b>\u00a0from <a title=\"File:Axial skeleton diagram.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Axial_skeleton_diagram.svg\">Axial skeleton diagram.svg<\/a>, by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats].<\/a><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Axial_skeleton_diagram_blank.svg\" rel=\"cc:attributionURL\">)<\/a>\r\n\r\n<strong>Figure 11.3.3<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cranial_bones_en_v2.svg\" rel=\"cc:attributionURL\">822px-Cranial_bones_en_v2.svg<\/a> by <a title=\"User:Was a bee\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Was_a_bee\">Was a bee<\/a> (adapted\/ reallocated text on original image <a title=\"File:Cranial bones en.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cranial_bones_en.svg\">File:Cranial bones en.svg<\/a>. by <a title=\"User:Edoarado\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Edoarado\">Edoarado<\/a>) on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) license.\r\n\r\n<strong>Figure 11.3.4<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Facial_skeleton_-_en.svg\" rel=\"cc:attributionURL\">Facial_skeleton_-_en.svg<\/a> by <a class=\"mw-userlink\" title=\"User:Was a bee\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Was_a_bee\">Was a bee<\/a> (adapted original image <a title=\"File:Es-Human skull front simplified (bones).svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Es-Human_skull_front_simplified_(bones).svg\">File:Es-Human skull front simplified (bones).svg<\/a>. by <a class=\"mw-redirect\" title=\"User:Cristobal carrasco\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Cristobal_carrasco\">Cristobal carrasco<\/a>) on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 11.3.5<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Spinal_column_curvature.png\" rel=\"cc:attributionURL\">Spinal_column_curvature<\/a> by <a class=\"extiw\" title=\"en:user:Vsion\" href=\"https:\/\/en.wikipedia.org\/wiki\/user:Vsion\">vsion<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 11.3.6<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:True_ribs_animation.gif\" rel=\"cc:attributionURL\">True_ribs_animation<\/a> from <a class=\"extiw\" title=\"en:Anatomography\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anatomography\">en:Anatomography<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/\">CC BY-SA 2.1 JP<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/deed.en) license. (Creator\/ licensor: <a class=\"external text\" href=\"http:\/\/lifesciencedb.jp\/bp3d\/info\/userGuide\/faq\/credit.html\" rel=\"nofollow\">\"BodyParts3D, \u00a9 The Database Center for Life Science licensed under CC Attribution-Share Alike 2.1 Japan.\"<\/a>)\r\n\r\n<strong>Figure 11.3.7<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:False_ribs_animation.gif\" rel=\"cc:attributionURL\">False_ribs_animation<\/a> from <a class=\"extiw\" title=\"en:Anatomography\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anatomography\">en:Anatomography<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/\">CC BY-SA 2.1 JP<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/deed.en) license. (Creator\/ licensor: <a class=\"external text\" href=\"http:\/\/lifesciencedb.jp\/bp3d\/info\/userGuide\/faq\/credit.html\" rel=\"nofollow\">\"BodyParts3D, \u00a9 The Database Center for Life Science licensed under CC Attribution-Share Alike 2.1 Japan.\"<\/a>)\r\n\r\n<strong>Figure 11.3.8<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Floating_ribs_animation.gif\" rel=\"cc:attributionURL\">Floating_ribs_animation<\/a> from <a class=\"extiw\" title=\"en:Anatomography\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anatomography\">en:Anatomography<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/\">CC BY-SA 2.1 JP<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/deed.en) license. (Creator\/ licensor: <a class=\"external text\" href=\"http:\/\/lifesciencedb.jp\/bp3d\/info\/userGuide\/faq\/credit.html\" rel=\"nofollow\">\"BodyParts3D, \u00a9 The Database Center for Life Science licensed under CC Attribution-Share Alike 2.1 Japan.\"<\/a>)\r\n\r\n<strong>Figure 11.3.9<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Appendicular_skeleton_diagram.svg\" rel=\"cc:attributionURL\">Appendicular_skeleton_diagram.svg<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats<\/a>] on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong style=\"text-align: initial; font-size: 1em;\">\r\nFigure 11.3.10<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Humerus,_ulna_and_radius_(female).png\" rel=\"cc:attributionURL\">Humerus,_ulna_and_radius_(female)<\/a> by <a title=\"User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is used and adapted by Christine Miller (addition of labels), as it has been released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 11.3.11<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Human_left_hand_bones_with_metacarpal_numbers_and_carpal_letters.svg\" rel=\"cc:attributionURL\">Human_left_hand_bones_with_metacarpal_numbers_and_carpal_letters.svg<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats<\/a>], Nyks, Bibi Saint-Pol. Bloub\u00e9ri. and Whidou on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) license.\r\n\r\n<strong>Figure 11.3.12<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Human_leg_bones_labeled.svg\" rel=\"cc:attributionURL\">Human_leg_bones_labeled.svg<\/a> by <a class=\"extiw\" title=\"wikipedia:User:Jecowa\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Jecowa\">Jecowa<\/a> (original uploader) at <a class=\"extiw\" title=\"wikipedia:\" href=\"https:\/\/en.wikipedia.org\/wiki\/\">English Wikipedia<\/a>on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 11.3.13<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0411_FootAnatomy.png\" rel=\"cc:attributionURL\">Blausen_0411_FootAnatomy<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a>\u00a0<span style=\"font-size: 1em;\">(<\/span><span style=\"text-align: initial; font-size: 1em;\">https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/span>\r\n\r\n<strong>Figure 11.3.14<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Pectoral_girdle_front_diagram.svg\" rel=\"cc:attributionURL\">Pectoral_girdle_front_diagram.svg<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats<\/a>] on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 11.3.15<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0723_Pelvis.png\" rel=\"cc:attributionURL\">2048px-Blausen_0723_Pelvis<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a>\u00a0<span style=\"font-size: 1em;\">(<\/span><span style=\"text-align: initial; font-size: 1em;\">https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/span>\r\n<h2>References<\/h2>\r\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\r\n<p class=\"hanging-indent\">Mayo Clinic. (2011, ). Craniosynostosis - Mayo Clinic. YouTube. https:\/\/www.youtube.com\/watch?v=fcHB2pvH2uc<\/p>\r\n<p class=\"hanging-indent\">Neural Academy. (2018, ). Bones of the skull - Learn in 4 minutes! YouTube. https:\/\/www.youtube.com\/watch?v=WRmNC_yPQZ8<\/p>","rendered":"<p>&nbsp;<\/p>\n<figure id=\"attachment_3974\" aria-describedby=\"caption-attachment-3974\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3974\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Human_skulls_on_display-2.jpg\" alt=\"11.3 Skulls on Display\" width=\"400\" height=\"266\" \/><figcaption id=\"caption-attachment-3974\" class=\"wp-caption-text\"><em>11.3.1 Skulls on display.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Skulls on Display<\/h1>\n<\/div>\n<p>This somewhat macabre display (Figure 11.3.1) can be viewed at the Slovak National Museum in Bratislava, Slovakia. The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3957\">skulls<\/a> are meant to represent normal human skeletal anatomy. The skull is part of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3953\">axial skeleton<\/a>, which is one of the two major divisions of the human skeleton. The other division is the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3954\">appendicular skeleton<\/a>.<\/p>\n<div>\n<h1>Axial Skeleton<\/h1>\n<\/div>\n<figure id=\"attachment_3955\" aria-describedby=\"caption-attachment-3955\" style=\"width: 429px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3955 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Axial_skeleton_diagram_blank.svg_-2.png\" alt=\"11.2 &amp; 11.3 Axial Skeleton\" width=\"429\" height=\"615\" \/><figcaption id=\"caption-attachment-3955\" class=\"wp-caption-text\"><em>Figure 11.3.2 The axial skeleton.<\/em><\/figcaption><\/figure>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3953\">axial skeleton<\/a>,<\/strong> shown in blue in Figure 11.3.2, consists of a total of 80 bones. Besides the skull, it includes the rib cage and vertebral column. It also includes the three tiny ossicles (hammer, anvil, and stirrup) in the middle ear and the hyoid bone in the throat, to which the tongue and some other soft tissues are attached.<\/p>\n<h2>Skull<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3957\">skull<\/a><\/strong> is the part of the human skeleton that provides a bony framework for the head. It consists of 22 different bones. There are eight bones in the cranium, which encloses the brain, and 14 bones in the face.<\/p>\n<h3>Cranium<\/h3>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3975\">cranium<\/a>\u00a0<\/strong>forms the entire upper portion of the skull. As shown in Figure 11.3.3, it consists of eight bones: one frontal bone, two parietal bones, two temporal bones, one occipital bone, one sphenoid bone, and one ethmoid bone. The ethmoid bone separates the nasal cavity from the brain. The sphenoid bone is one of several bones, including the frontal bone, that help form the eye sockets. The other bones of the cranium are large and plate-like. They cover and protect the brain. The bottom of the skull has openings for major blood vessels and nerves. A large opening, called the foramen, connects the spinal cord and brain.<\/p>\n<figure id=\"attachment_3976\" aria-describedby=\"caption-attachment-3976\" style=\"width: 426px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3976\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/822px-Cranial_bones_en_v2.svg_-2.png\" alt=\"11.3.3 Cranial Bones\" width=\"426\" height=\"308\" \/><figcaption id=\"caption-attachment-3976\" class=\"wp-caption-text\"><em>Figure 11.3.3 The cranium consists of eight bones that are fused together at their joints.<\/em><\/figcaption><\/figure>\n<h3>Facial Bones<\/h3>\n<p>The 14 facial bones of the skull are located below the frontal bone of the cranium, and they are depicted in Figure 11.3.4. Large bones in the face include the upper jaw bones, or <strong>maxillae (singular, maxilla),<\/strong>\u00a0which form the middle part of the face and the bottom of the two eye sockets. The maxillae are fused together, except for an opening between them for the nose. The lower edge of the maxillae contains sockets for the upper teeth. The lower jaw bone, or\u00a0<strong>mandible,<\/strong> is also large. The top edge of the mandible contains sockets for the lower teeth. The mandible opens and closes to chew food and is controlled by strong muscles. There are two zygomatic (or cheek) bones and two nasal bones. The nasal region also contains seven smaller bones, as indicated in Figure 11.3.4.<\/p>\n<figure id=\"attachment_3978\" aria-describedby=\"caption-attachment-3978\" style=\"width: 548px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3978\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Facial_skeleton_-_en.svg_-2.png\" alt=\"11.3.4 Facial Bones\" width=\"548\" height=\"481\" \/><figcaption id=\"caption-attachment-3978\" class=\"wp-caption-text\"><em>Figure 11.3.4 The 14 bones that make up the face are labeled in this drawing of the skull.<\/em><\/figcaption><\/figure>\n<h2>Vertebral Column<\/h2>\n<figure id=\"attachment_4000\" aria-describedby=\"caption-attachment-4000\" style=\"width: 313px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4000\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Spinal_column_curvature-2.png\" alt=\"11.3.5 Vertebral Column\" width=\"313\" height=\"486\" \/><figcaption id=\"caption-attachment-4000\" class=\"wp-caption-text\"><em>Figure 11.3.5 The vertebral column consists of 24 individual vertebrae that are separated by intervertebral discs of cartilage. An additional nine vertebrae are fused together at the base of the spine. Note the S-shaped curve of the vertebral column in the profile view on the right.<\/em><\/figcaption><\/figure>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3958\">vertebral column<\/a><\/strong>\u00a0\u2014 also called the spine or backbone \u2014 is the flexible column of\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3964\">vertebrae<\/a> (singular, vertebra)<\/strong> that connects the trunk with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3957\">skull<\/a> and encloses the spinal cord. It consists of 33 vertebrae that are divided into five regions, as shown in Figure 11.3.5: the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3979\">cervical<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5491\">thoracic<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3998\">lumbar<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3999\">sacral<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_6453\">coccygeal<\/a> regions. From the neck down, the first 24 vertebrae (cervical, thoracic, and lumbar) are individual bones. The five sacral vertebrae are fused together, as are the four coccygeal vertebrae.<\/p>\n<p><span style=\"text-align: initial; font-size: 1em;\">The vertebral column consists of 24 individual vertebrae that are separated by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4001\">intervertebral disc<\/a>s of cartilage. An additional nine vertebrae are fused together at the base of the spine. Note the S-shaped curve of the vertebral column in the profile view in Figure 11.3.5 on the left.<\/span><\/p>\n<p>The human vertebral column reflects adaptations for upright bipedal locomotion (walking upright on two legs). For example, the vertebral column is less like a rigid column than an S-shaped spring (see profile view in Figure 11.3.5). Although newborn infants have a relatively straight spine, the curves develop as the backbone starts taking on its support functions, such as keeping the trunk erect, holding up the head, and helping to anchor the limbs. The S shape of the vertebral column allows it to act like a shock absorber, absorbing much of the jarring of walking and running so the forces are not transmitted directly from the pelvis to the skull. The S shape also helps protect the spine from breaking, which would be more likely with a straight, more rigid vertebral column. In addition, the S shape helps to distribute the weight of the body \u2014 particularly of the internal organs, so the weight load is not all at the bottom, as would occur with a straight spine.<\/p>\n<h2>Rib Cage<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4002\">rib cage<\/a><\/strong> (also called thoracic cage) is aptly named, because it forms a sort of cage that holds within it the organs of the upper part of the trunk, including the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2987\">heart<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2990\">lungs<\/a>. It is shown in Figures 11.3.6\u201311.3.8. The rib cage includes the 12 thoracic vertebrae and the sternum, as well as 12 pairs of ribs, which are attached at joints to the vertebrae. The ribs are divided into three groups, called true ribs, false ribs, and floating ribs. The top seven pairs of ribs are true ribs. They are attached by cartilage directly to the sternum. The next three pairs of ribs are false ribs. They are attached by cartilage to the ribs above them, rather than directly to the sternum. The lowest two pairs of ribs are floating ribs. They are attached by cartilage to muscles in the abdominal wall. The attachments of false and floating ribs let the lower part of the rib cage expand to accommodate the internal movements of breathing.<\/p>\n<table class=\"no-lines\" style=\"border-collapse: collapse; width: 100%; height: 206px;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%;\">\n<figure id=\"attachment_4003\" aria-describedby=\"caption-attachment-4003\" style=\"width: 213px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4003\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/True_ribs_animation-2.gif\" alt=\"11.3.6 True Ribs\" width=\"213\" height=\"213\" \/><figcaption id=\"caption-attachment-4003\" class=\"wp-caption-text\"><em>Figure 11.3.6 True ribs are attached to both the vertebrae and the sternum.\u00a0 In this image, true ribs are highlighted in red.<\/em><\/figcaption><\/figure>\n<\/td>\n<td style=\"width: 33.3333%;\">\n<figure id=\"attachment_4004\" aria-describedby=\"caption-attachment-4004\" style=\"width: 214px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4004\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/False_ribs_animation-2.gif\" alt=\"11.3.7 False Ribs\" width=\"214\" height=\"214\" \/><figcaption id=\"caption-attachment-4004\" class=\"wp-caption-text\"><em>Figure 11.3.7 False ribs are attached to the vertebrae and to the ribs above them by cartilage.\u00a0 In this image, false ribs and floating ribs are highlighted in red.<\/em><\/figcaption><\/figure>\n<\/td>\n<td style=\"width: 33.3333%;\">\n<figure id=\"attachment_4005\" aria-describedby=\"caption-attachment-4005\" style=\"width: 222px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4005\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Floating_ribs_animation-2.gif\" alt=\"11.3.8 Floating Ribs\" width=\"222\" height=\"222\" \/><figcaption id=\"caption-attachment-4005\" class=\"wp-caption-text\"><em>Figure 11.3.8 Floating ribs are attached to vertebrae and the the muscles in the abdominal wall. In this image floating ribs are highlighted in red.<\/em><\/figcaption><\/figure>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<p><span style=\"font-size: 1.602em; font-weight: bold;\">Appendicular Skeleton<\/span><\/p>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3954\">appendicular skeleton<\/a>,<\/strong> shown in red (Figure 11.3.9), consists of a total of 126 bones. It includes all the bones of the limbs (arms, legs, hands, and feet,) as well as the bones of the shoulder (shoulder girdle) and pelvis (pelvic girdle).<\/p>\n<figure id=\"attachment_4006\" aria-describedby=\"caption-attachment-4006\" style=\"width: 373px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4006\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Appendicular_skeleton_diagram.svg_-2.png\" alt=\"11.3.9 Appendicular Skeleton\" width=\"373\" height=\"690\" \/><figcaption id=\"caption-attachment-4006\" class=\"wp-caption-text\"><em>Figure 11.3.9 The appendicular skeleton includes the upper and lower appendages and girdles.<\/em><\/figcaption><\/figure>\n<h2>Upper Limbs<\/h2>\n<p>Each upper limb consists of 30 bones. As shown in Figure 11.3.10, there is one bone (called the humerus) in each of the upper arms, and there are two bones (called the ulna and radius) in each of the lower arms. The remaining bones of the upper limb are shown in Figure 11.3.11. Each wrist contains eight carpal bones \u2014 which are arranged in two rows of four bones each \u2014 and each hand contains five metacarpal bones. The bones in the fingers of each hand include 14 phalanges (three in each finger except the thumb, which has two phalanges). The thumb has the unique ability to move into opposition with the palm of the hand, and with each of the fingers when they are slightly bent. This allows the hand to handle and manipulate objects such as tools.<\/p>\n<figure id=\"attachment_4007\" aria-describedby=\"caption-attachment-4007\" style=\"width: 185px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4007\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Humerus_ulna_and_radius_female-2.png\" alt=\"11.3.10 Bones of the Arm\" width=\"185\" height=\"318\" \/><figcaption id=\"caption-attachment-4007\" class=\"wp-caption-text\">Figure 11.3.10 The arm consists of three bones: the humerus, radius and ulna.<\/figcaption><\/figure>\n<figure id=\"attachment_4008\" aria-describedby=\"caption-attachment-4008\" style=\"width: 400px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4008\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Human_left_hand_bones_with_metacarpal_numbers_and_carpal_letters.svg_-2.png\" alt=\"11.3.11 Bones of the hand\" width=\"400\" height=\"327\" \/><figcaption id=\"caption-attachment-4008\" class=\"wp-caption-text\">Figure 11.3.11 Bones of the wrist (carpals A-E) and hand (metacarpals 1-5 and phalanges).<\/figcaption><\/figure>\n<h2>Lower Limbs<\/h2>\n<figure id=\"attachment_4009\" aria-describedby=\"caption-attachment-4009\" style=\"width: 236px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4009\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Human_leg_bones_labeled.svg_-2.png\" alt=\"11.3.12 Bones of the Legs\" width=\"236\" height=\"357\" \/><figcaption id=\"caption-attachment-4009\" class=\"wp-caption-text\"><em>Figure 11.3.12 Bones of the legs.<\/em><\/figcaption><\/figure>\n<p>Each lower limb consists of 30 bones. As shown in Figure 11.3.12 to the left, there is one bone (called the femur) in each of the upper legs, and there are two bones (called the tibia and fibula) in each of the lower legs. The knee cap (or patella) is an additional leg bone at the front of each knee, which is the largest joint in the human body.<\/p>\n<figure id=\"attachment_4010\" aria-describedby=\"caption-attachment-4010\" style=\"width: 233px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4010\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0411_FootAnatomy-2.png\" alt=\"11.3.13 Bones of the foot\" width=\"233\" height=\"466\" \/><figcaption id=\"caption-attachment-4010\" class=\"wp-caption-text\"><em>Figure 11.3.13 Bones of the lower leg (fibula and tibia), ankle (talus), heel (calcaneus), foot (metatarsals), and toes (phalanges).<\/em><\/figcaption><\/figure>\n<p>The remaining bones of the lower limbs are in Figure 11.3.13 to the right. Each ankle contains seven tarsal bones (including the talus and calcaneus), and each foot contains five metatarsal bones. The tarsals and metatarsals form the ankle, heel, and arch of the foot. They give the foot strength while allowing flexibility. The bones in the toes of each foot consist of 14 phalanges (three in each toe except the big toe, which has two phalanges)<\/p>\n<p><span style=\"text-align: initial; font-size: 1em;\">Bones of the lower leg (fibula and tibia), ankle (talus), heel (calcaneus), foot (metatarsals), and toes (phalanges)<\/span><\/p>\n<h2>Shoulder Girdle<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4012\">pectoral girdle<\/a><\/strong> (also called shoulder girdle) attaches the upper limbs to the trunk of the body. It is connected to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3953\">axial skeleton<\/a> by muscles alone. This allows a considerable range of motion in the upper limbs. The shoulder girdle consists of just two pairs of bones, with one of each pair on opposite sides of the body (see Figure 11.3.14). There are a right and left clavicle (collarbone), and a right and left scapula (shoulder blade). The scapula is a pear-shaped flat bone that helps form the shoulder joint. The clavicle is a long bone that serves as a strut between the shoulder blade and the sternum.<\/p>\n<figure id=\"attachment_4013\" aria-describedby=\"caption-attachment-4013\" style=\"width: 428px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4013\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Pectoral_girdle_front_diagram.svg_-2.png\" alt=\"11.3.14 Bones of the Shoulder Girdle\" width=\"428\" height=\"336\" \/><figcaption id=\"caption-attachment-4013\" class=\"wp-caption-text\"><em>Figure 11.3.14 Bones of the shoulder girdle.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"font-size: 1.424em; font-weight: bold;\">Pelvic Girdle<\/span><\/p>\n<\/div>\n<figure id=\"attachment_4014\" aria-describedby=\"caption-attachment-4014\" style=\"width: 446px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4014\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2048px-Blausen_0723_Pelvis-2.png\" alt=\"11.3.15 Bones of the Pelvic Girdle\" width=\"446\" height=\"446\" \/><figcaption id=\"caption-attachment-4014\" class=\"wp-caption-text\"><em>Figure 11.3.15 Bones of the pelvic girdle.<\/em><\/figcaption><\/figure>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3963\">pelvic girdle<\/a><\/strong> attaches the legs to the trunk of the body, and also provides a basin to contain and support the organs of the abdomen. It is connected to the vertebral column of the axial skeleton by ligaments. The pelvic girdle consists of two halves \u2014 one half for each leg \u2014 but the halves are fused with each other in adults at a joint called the pubic symphysis. Each half of the pelvic girdle includes three bones, as shown in Figure 11.3.15 to the right: the ilium (flaring upper part of the pelvic girdle), pubis (lower front), and ischium (lower back). Each of these bones helps form the acetabulum, which is a depression into which the top of the femur (thighbone) fits. When the body is in a seated position, it rests on protrusions (called tuberosities) of the two ischial bones.<\/p>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">11.3 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3953\">axial skeleton<\/a> consists of a total of 80 bones. It includes the skull, vertebral column, and rib cage. It also includes the three tiny ossicles in the middle ear and the hyoid bone in the throat.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3957\">skull<\/a> provides a bony framework for the head. It consists of 22 different bones:\u00a0eight\u00a0in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3975\">cranium<\/a> (which encloses the brain) and 14 in the face (which includes the upper and lower jaw).<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3958\">vertebral column<\/a> is a flexible, S-shaped column of 33 vertebrae that connects the trunk with the skull and encloses the spinal cord. The vertebrae are divided into five regions: cervical, thoracic, lumbar, sacral, and coccygeal regions. The S shape of the vertebral column allows it to absorb shocks and distribute the weight of the body.<\/li>\n<li>The rib cage holds and protects the organs of the upper part of the trunk, including the heart and lungs. It includes the 12 thoracic vertebrae, the sternum, and 12 pairs of ribs.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3954\">appendicular skeleton<\/a> consists of a total of 126 bones. It includes the bones of the four limbs, shoulder girdle, and pelvic girdle.<\/li>\n<li>Each upper limb consists of 30 bones. There is one bone (called the humerus) in the upper arm, and two bones (called the ulna and radius) in the lower arm. The wrist contains\u00a0eight\u00a0carpal bones, the hand contains\u00a0five\u00a0metacarpals, and the fingers consist of 14 phalanges. The thumb is opposable to the palm and fingers of the same hand.<\/li>\n<li>Each lower limb also consists of 30 bones. There is one bone (called the femur) in the upper leg, and two bones (called the tibia and fibula) in the lower leg. The patella covers the knee joint. The ankle contains\u00a0seven\u00a0tarsal bones, and the foot contains\u00a0five\u00a0metatarsals. The tarsals and metatarsals form the heel and arch of the foot. The bones in the toes consist of 14 phalanges.<\/li>\n<li>The shoulder girdle attaches the upper limbs to the trunk of the body. It is connected to the axial skeleton only by muscles, allowing mobility of the upper limbs. Bones of the shoulder girdle include a right and left clavicle, as well as a right and left scapula.<\/li>\n<li>The pelvic girdle attaches the legs to the trunk of the body, and supports the organs of the abdomen. It is connected to the axial skeleton by ligaments. The pelvic girdle consists of two halves that are fused together in adults. Each half consists of three bones: the ilium, pubis, and ischium.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">11.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-593\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-593\" class=\"h5p-iframe\" data-content-id=\"593\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"11.3 Drag and Drop Bone sort\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>\n<div id=\"h5p-594\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-594\" class=\"h5p-iframe\" data-content-id=\"594\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"11.3 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What are the advantages of an S-shaped vertebral column?<\/li>\n<li>What is the rib cage? What is its function?\u00a0 What types of ribs are there?<\/li>\n<li>Explain the advantage of having some ribs that are not attached directly to the sternum.<\/li>\n<li>What is the shoulder girdle? Why does it allow considerable upper limb mobility?<\/li>\n<li>Describe some of the similarities between the upper limbs and the lower limbs.<\/li>\n<li>Describe the pelvic girdle and the bones it contains.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">11.3 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"BONES OF THE SKULL - LEARN IN 4 MINUTES\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/WRmNC_yPQZ8?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Bones of the skull &#8211; Learn in 4 minutes! Neural Academy, 2018.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"Craniosynostosis - Mayo Clinic\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/fcHB2pvH2uc?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Craniosynostosis &#8211; Mayo Clinic, 2011.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 11.3.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Human_skulls_on_display.JPG\" rel=\"cc:attributionURL\">Human_skulls_on_display<\/a> by <a title=\"User:Kiwiev\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kiwiev\">Kiwiev<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) license.<\/p>\n<p><strong style=\"text-align: initial; font-size: 1em;\"><br \/>\nFigure 11.3.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Axial_skeleton_diagram_blank.svg\" rel=\"cc:attributionURL\">Axial_skeleton_diagram_blank.svg<\/a> by <a title=\"User:Qllach\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Qllach\">Quico\/ <\/a><a title=\"User:Qllach\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Qllach\">Qllach<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain). (This is a derivative work<b><\/b>\u00a0from <a title=\"File:Axial skeleton diagram.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Axial_skeleton_diagram.svg\">Axial skeleton diagram.svg<\/a>, by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats].<\/a><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Axial_skeleton_diagram_blank.svg\" rel=\"cc:attributionURL\">)<\/a><\/p>\n<p><strong>Figure 11.3.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cranial_bones_en_v2.svg\" rel=\"cc:attributionURL\">822px-Cranial_bones_en_v2.svg<\/a> by <a title=\"User:Was a bee\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Was_a_bee\">Was a bee<\/a> (adapted\/ reallocated text on original image <a title=\"File:Cranial bones en.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cranial_bones_en.svg\">File:Cranial bones en.svg<\/a>. by <a title=\"User:Edoarado\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Edoarado\">Edoarado<\/a>) on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) license.<\/p>\n<p><strong>Figure 11.3.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Facial_skeleton_-_en.svg\" rel=\"cc:attributionURL\">Facial_skeleton_-_en.svg<\/a> by <a class=\"mw-userlink\" title=\"User:Was a bee\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Was_a_bee\">Was a bee<\/a> (adapted original image <a title=\"File:Es-Human skull front simplified (bones).svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Es-Human_skull_front_simplified_(bones).svg\">File:Es-Human skull front simplified (bones).svg<\/a>. by <a class=\"mw-redirect\" title=\"User:Cristobal carrasco\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Cristobal_carrasco\">Cristobal carrasco<\/a>) on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 11.3.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Spinal_column_curvature.png\" rel=\"cc:attributionURL\">Spinal_column_curvature<\/a> by <a class=\"extiw\" title=\"en:user:Vsion\" href=\"https:\/\/en.wikipedia.org\/wiki\/user:Vsion\">vsion<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 11.3.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:True_ribs_animation.gif\" rel=\"cc:attributionURL\">True_ribs_animation<\/a> from <a class=\"extiw\" title=\"en:Anatomography\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anatomography\">en:Anatomography<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/\">CC BY-SA 2.1 JP<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/deed.en) license. (Creator\/ licensor: <a class=\"external text\" href=\"http:\/\/lifesciencedb.jp\/bp3d\/info\/userGuide\/faq\/credit.html\" rel=\"nofollow\">&#8220;BodyParts3D, \u00a9 The Database Center for Life Science licensed under CC Attribution-Share Alike 2.1 Japan.&#8221;<\/a>)<\/p>\n<p><strong>Figure 11.3.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:False_ribs_animation.gif\" rel=\"cc:attributionURL\">False_ribs_animation<\/a> from <a class=\"extiw\" title=\"en:Anatomography\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anatomography\">en:Anatomography<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/\">CC BY-SA 2.1 JP<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/deed.en) license. (Creator\/ licensor: <a class=\"external text\" href=\"http:\/\/lifesciencedb.jp\/bp3d\/info\/userGuide\/faq\/credit.html\" rel=\"nofollow\">&#8220;BodyParts3D, \u00a9 The Database Center for Life Science licensed under CC Attribution-Share Alike 2.1 Japan.&#8221;<\/a>)<\/p>\n<p><strong>Figure 11.3.8<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Floating_ribs_animation.gif\" rel=\"cc:attributionURL\">Floating_ribs_animation<\/a> from <a class=\"extiw\" title=\"en:Anatomography\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anatomography\">en:Anatomography<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/\">CC BY-SA 2.1 JP<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.1\/jp\/deed.en) license. (Creator\/ licensor: <a class=\"external text\" href=\"http:\/\/lifesciencedb.jp\/bp3d\/info\/userGuide\/faq\/credit.html\" rel=\"nofollow\">&#8220;BodyParts3D, \u00a9 The Database Center for Life Science licensed under CC Attribution-Share Alike 2.1 Japan.&#8221;<\/a>)<\/p>\n<p><strong>Figure 11.3.9<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Appendicular_skeleton_diagram.svg\" rel=\"cc:attributionURL\">Appendicular_skeleton_diagram.svg<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats<\/a>] on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong style=\"text-align: initial; font-size: 1em;\"><br \/>\nFigure 11.3.10<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Humerus,_ulna_and_radius_(female).png\" rel=\"cc:attributionURL\">Humerus,_ulna_and_radius_(female)<\/a> by <a title=\"User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is used and adapted by Christine Miller (addition of labels), as it has been released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 11.3.11<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Human_left_hand_bones_with_metacarpal_numbers_and_carpal_letters.svg\" rel=\"cc:attributionURL\">Human_left_hand_bones_with_metacarpal_numbers_and_carpal_letters.svg<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats<\/a>], Nyks, Bibi Saint-Pol. Bloub\u00e9ri. and Whidou on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) license.<\/p>\n<p><strong>Figure 11.3.12<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Human_leg_bones_labeled.svg\" rel=\"cc:attributionURL\">Human_leg_bones_labeled.svg<\/a> by <a class=\"extiw\" title=\"wikipedia:User:Jecowa\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Jecowa\">Jecowa<\/a> (original uploader) at <a class=\"extiw\" title=\"wikipedia:\" href=\"https:\/\/en.wikipedia.org\/wiki\/\">English Wikipedia<\/a>on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 11.3.13<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0411_FootAnatomy.png\" rel=\"cc:attributionURL\">Blausen_0411_FootAnatomy<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a>\u00a0<span style=\"font-size: 1em;\">(<\/span><span style=\"text-align: initial; font-size: 1em;\">https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/span><\/p>\n<p><strong>Figure 11.3.14<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Pectoral_girdle_front_diagram.svg\" rel=\"cc:attributionURL\">Pectoral_girdle_front_diagram.svg<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats<\/a>] on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 11.3.15<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0723_Pelvis.png\" rel=\"cc:attributionURL\">2048px-Blausen_0723_Pelvis<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a>\u00a0<span style=\"font-size: 1em;\">(<\/span><span style=\"text-align: initial; font-size: 1em;\">https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/span><\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">Mayo Clinic. (2011, ). Craniosynostosis &#8211; Mayo Clinic. YouTube. https:\/\/www.youtube.com\/watch?v=fcHB2pvH2uc<\/p>\n<p class=\"hanging-indent\">Neural Academy. (2018, ). Bones of the skull &#8211; Learn in 4 minutes! YouTube. https:\/\/www.youtube.com\/watch?v=WRmNC_yPQZ8<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4935_3957\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3957\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by: Christine Miller<\/p>\n<h1 style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em\">What Is Pseudoscience?<\/h1>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3497\">Pseudoscience<\/a><\/strong>\u00a0is a claim, belief, or practice that is presented as scientific but does not adhere to the standards and methods of science. True science is based on repeated evidence-gathering and testing of falsifiable hypotheses. Pseudoscience does not adhere to these criteria.\u00a0In addition to\u00a0phrenology, some other examples of pseudoscience include astrology, extrasensory perception (ESP), reflexology, reincarnation, and Scientology,<\/p>\n<h2>Characteristics of Pseudoscience<\/h2>\n<p>Whether a field is actually science or just pseudoscience is not always clear. However, pseudoscience generally exhibits certain common characteristics. Indicators of pseudoscience include:<\/p>\n<ul>\n<li><strong>The use of vague, exaggerated, or untestable claims:<\/strong>\u00a0Many claims made by pseudoscience cannot be tested with evidence. As a result, they cannot be falsified, even if they are not true.<\/li>\n<li><strong>An over-reliance on confirmation rather than refutation:<\/strong>\u00a0Any incident that appears to justify a pseudoscience claim is treated as proof of the claim. Claims are assumed true until proven otherwise, and\u00a0the burden of disproof is placed on skeptics of the claim.<\/li>\n<li><strong>A lack of openness to testing by other experts:<\/strong>\u00a0Practitioners of pseudoscience avoid subjecting their ideas to peer review. They may refuse to share their data and justify the need for secrecy\u00a0with\u00a0claims\u00a0of proprietary or privacy.<\/li>\n<li><strong>An\u00a0absence of progress in advancing knowledge:<\/strong>\u00a0In pseudoscience, ideas are not subjected to repeated testing followed by rejection or refinement, as hypotheses are in true science. Ideas in pseudoscience\u00a0may remain unchanged for hundreds \u2014 or even thousands \u2014 of years. In fact, the older an idea is, the more it tends to be trusted in pseudoscience.<\/li>\n<li><strong>Personalization of issues:<\/strong>\u00a0Proponents of pseudoscience adopt beliefs that have little or no rational basis, so they may try to confirm their beliefs by treating critics as enemies. Instead of arguing to support their own beliefs, they attack the motives and character of their critics.<\/li>\n<li><strong>The use of misleading language:<\/strong>\u00a0Followers of pseudoscience may use scientific-sounding terms to make their ideas sound more convincing. For example, they may use the formal name dihydrogen monoxide to refer to\u00a0plain old water.<\/li>\n<\/ul>\n<h2>Persistence of Pseudoscience<\/h2>\n<p>Despite failing to meet scientific standards, many pseudosciences survive. Some pseudosciences remain very popular with large numbers of believers. A good example is astrology.<\/p>\n<p>Astrology is\u00a0the study of the movements and relative positions of celestial objects as a means for divining information about human affairs and terrestrial events. Many ancient cultures attached importance to astronomical events, and some developed elaborate systems for predicting terrestrial events from celestial observations. Throughout most of its history in the West, astrology was considered a scholarly tradition and was common in academic circles. With the advent of modern Western science, astrology was called into question. It was challenged on both theoretical and experimental grounds, and it was eventually shown to have no scientific validity or explanatory power.<\/p>\n<figure id=\"attachment_58\" aria-describedby=\"caption-attachment-58\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img class=\"wp-image-58 size-medium\" title=\"Image in the public domain.\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/zodiac-29420_1280-1.png\" alt=\"\" width=\"300\" height=\"212\"><figcaption id=\"caption-attachment-58\" class=\"wp-caption-text\"><em>Figure 1.7.1 Zodiac signs.<\/em><\/figcaption><\/figure>\n<p>Today, astrology is considered a pseudoscience, yet it continues to have many devotees. Most people know their astrological sign, and many people are familiar with the personality traits supposedly associated with their sign. Astrological readings and horoscopes are readily available online and in print media, and a lot of people read them,\u00a0even if only occasionally. About a third of all adult Americans actually believe that astrology is scientific. Studies suggest that the\u00a0persistent popularity of pseudosciences such as astrology reflects a high level of scientific illiteracy. It seems that many Americans do not have an accurate understanding of scientific principles and methodology. They are not convinced by scientific arguments against their beliefs.<\/p>\n<h2>Dangers of Pseudoscience<\/h2>\n<p>Belief in astrology\u00a0is unlikely to\u00a0cause a person harm, but belief in some other pseudosciences might \u2014 especially in\u00a0health care-related areas. Treatments that seem scientific but are not may be ineffective, expensive, and even dangerous to patients. Seeking out pseudoscientific treatments may also delay or preclude patients from seeking scientifically-based medical treatments that have been tested and found safe and effective. In short, irrational health care may not be harmless.<\/p>\n<div>\n<h1>Scientific Hoaxes, Frauds, and Fallacies<\/h1>\n<\/div>\n<p>Pseudoscience is not the only way that science may be misused. Scientific <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3499\"><strong>hoaxes<\/strong><\/a>, frauds, and fallacies may misdirect the pursuit of science, put patients at risk, or mislead and confuse the public. An example of each of these misuses of science and its negative effects is described below.<\/p>\n<h2>The Piltdown Hoax<\/h2>\n<figure id=\"attachment_59\" aria-describedby=\"caption-attachment-59\" style=\"width: 233px\" class=\"wp-caption alignleft\"><img class=\"wp-image-59\" title=\"Image by By James Howard McGregor [Public domain], via Wikimedia Commons\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Piltdown-Man-1.jpg\" alt=\"A side profile view of an artists rendition of what the Piltdown Man may have looked like, had he been real.\" width=\"233\" height=\"221\"><figcaption id=\"caption-attachment-59\" class=\"wp-caption-text\"><em>Figure 1.7.2 This reconstruction of Piltdown Man's head was based on jaw and skull bone fragments.<\/em><\/figcaption><\/figure>\n<p>Piltdown Man (see picture left) was a paleontological hoax in which bone fragments were presented as the fossilized remains of a previously unknown early human. These fragments consisted of parts of a skull and jawbone, reported to have been found in 1908 in a gravel pit at Piltdown, East Sussex, England. The significance of the specimen remained the subject of controversy until it was exposed in 1953 as a hoax. It eventually came to light that the specimen consisted of the lower jawbone of an orangutan deliberately combined with skull bones of a modern human. The Piltdown hoax is perhaps the most infamous paleontological hoax ever perpetrated, both for its impact on the direction of research on human evolution and for the length of time\u00a0between\u00a0its \"discovery\"\u00a0and\u00a0its full exposure as a forgery.<\/p>\n<figure id=\"attachment_60\" aria-describedby=\"caption-attachment-60\" style=\"width: 247px\" class=\"wp-caption alignright\"><img class=\"wp-image-60\" title=\"Photo by Anrie [CC BY-SA 3.0 (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0)], from Wikimedia Commons\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Sterkfontein_Piltdown_man-1.jpg\" alt=\"A replica of the infamous Piltdown skull. The skull is encased in a glass sphere. The replica shows portions of the skull which were bone in white, and the portions of the skull which were inferred in black.\" width=\"247\" height=\"242\"><figcaption id=\"caption-attachment-60\" class=\"wp-caption-text\"><em>Figure 1.7.3 A replica of the infamous Piltdown skull.<\/em><\/figcaption><\/figure>\n<p>In 1912, the head of the geological department at the British Museum proposed that Piltdown man represented an evolutionary missing link between apes and humans. With its human-like cranium and ape-like jaw, it seemed to support the idea then prevailing in England that human evolution began with the brain. The Piltdown specimen led scientists down a blind alley in the belief that the human brain increased in size before the jaw underwent size reductions to become more like the modern human jaw. This belief confused and misdirected the study of human evolution for decades, and actual fossils of early humans were ignored because they didn't support the accepted paradigm.<\/p>\n<h2>The Vaccine-Autism Fraud<\/h2>\n<p>You may have heard that certain vaccines put the health of young children at risk. This persistent idea is not supported by scientific evidence or accepted by the vast majority of experts in the field. It stems largely from an elaborate medical research fraud that was reported in a 1998 article published in the respected British medical journal,\u00a0<em>The Lancet.<\/em>\u00a0The main author of the article was a British physician named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Andrew_Wakefield\">Andrew Wakefield<\/a>. In the article, Wakefield and his colleagues described case histories of 12 children, most of whom were reported to have developed autism soon after the administration of the MMR (measles,\u00a0mumps,\u00a0rubella) vaccine.<\/p>\n<p>Several subsequent peer-reviewed studies failed to show any association between the MMR vaccine and autism. It also later emerged that Wakefield had received research funding from a group of people who were suing vaccine manufacturers.\u00a0In 2004, ten of Wakefield's 12 coauthors formally retracted the conclusions\u00a0in\u00a0their paper. In 2010, editors of\u00a0<em>The Lancet<\/em>retracted the entire paper. That same year, Wakefield was charged with deliberate falsification of research and barred from practicing medicine in the United Kingdom. Unfortunately, by then, the damage had already been done. Parents afraid that their children would develop autism had refrained from having them vaccinated. British MMR vaccination rates fell from nearly 100 per cent to 80 per cent in the years following the study. The consensus of medical experts today is that Wakefield's fraud put hundreds of thousands of children at risk because of the lower vaccination rates and also diverted research efforts and funding away from finding the true cause of autism.<\/p>\n<h2>Correlation-Causation Fallacy<\/h2>\n<p>Many statistical tests used in scientific research calculate correlations between variables. Correlation refers to how closely related two data sets are, which may be a useful starting point for further investigation. Correlation, however, is also one of the most misused types of evidence, primarily because of the logical fallacy that correlation implies causation. In reality, just because two variables are correlated does not\u00a0<em>necessarily<\/em>\u00a0mean that either variable causes the other.<\/p>\n<p>A few simple examples, illustrated by the graphs\u00a0below, can be used to demonstrate the correlation-causation fallacy. Assume a study found that both per capita consumption of mozzarella cheese and the number of Civil Engineering doctorates awarded are correlated; that is, rates of both events increase together. If correlation really did imply causation, then you could conclude from the second example that the increase in age of Miss America causes an increase in murders of a specific type or vice versa.<\/p>\n<figure id=\"attachment_126\" aria-describedby=\"caption-attachment-126\" style=\"width: 900px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-126\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cheese-and-Degrees-4-1.png\" alt=\"A chart showing the correlation between per capita consumption of mozzarella cheese, and the number of civil engineering doctorates awarded.\" width=\"900\" height=\"355\"><figcaption id=\"caption-attachment-126\" class=\"wp-caption-text\">Figure 1.7.4 Spurious Correlations [Causation Fallacy] - Consumption of mozzarella cheese and awarded Doctorates<\/figcaption><\/figure>\n<figure id=\"attachment_141\" aria-describedby=\"caption-attachment-141\" style=\"width: 900px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-141\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Ms-America-and-Murder-1-1-scaled.jpg\" alt=\"A chart showing a correlation between the age of Miss America, and the number of Murders by steam, hot vapours, and hot objects.\" width=\"900\" height=\"355\"><figcaption id=\"caption-attachment-141\" class=\"wp-caption-text\">Figure 1.7.5 Spurious Correlations (Causation Fallacy)- Miss America and Murder<\/figcaption><\/figure>\n<p>An actual example of the correlation-causation fallacy occurred during the latter half of the 20th century. Numerous studies showed that women taking hormone replacement therapy (HRT) to treat menopausal symptoms also had a lower-than-average incidence of coronary heart disease (CHD). This correlation was misinterpreted as evidence that HRT protects women against CHD. Subsequent studies that controlled other factors related to CHD disproved this presumed causal connection. The studies found that women taking HRT were more likely to come from higher socio-economic groups, with better-than-average diets and exercise regimens. Rather than HRT causing lower CHD incidence, these studies concluded that HRT and lower CHD were both effects of higher socio-economic status and related lifestyle factors.<\/p>\n<p>Check out this \u201cRough Guide to Spotting Bad Science\u201d infographic from Compound Interest:<\/p>\n<figure id=\"attachment_74\" aria-describedby=\"caption-attachment-74\" style=\"width: 1754px\" class=\"wp-caption alignnone\"><img class=\"wp-image-74 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Guide-to-Spotting-Bad-Science-1.png\" alt=\"\" width=\"1754\" height=\"2480\"><figcaption id=\"caption-attachment-74\" class=\"wp-caption-text\">Figure 1.7.6 A Rough Guide to Spotting Bad Science.<\/figcaption><\/figure>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">1.7 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Pseudoscience is a claim, belief, or practice that is presented as scientific, but does not adhere to scientific standards and methods.<\/li>\n<li>Indicators of pseudoscience include untestable claims, lack of openness to testing by experts, absence of progress in advancing knowledge, and attacks\u00a0on the\u00a0motives and character of critics.<\/li>\n<li>Some pseudosciences, including astrology, remain popular. This suggests\u00a0that many people do not possess the scientific literacy needed to distinguish\u00a0pseudoscience\u00a0from true science, or to be convinced by scientific arguments against them.<\/li>\n<li>Belief in a pseudoscience such as astrology is unlikely to cause harm, but belief in pseudoscientific medical treatments may be harmful.<\/li>\n<li>In addition to pseudoscience, other examples of the misuse of science include scientific hoaxes (such as the Piltdown hoax), scientific frauds (such as the MMR vaccine-autism fraud), and scientific fallacies (such as the correlation-causation fallacy).<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">1.7 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Define pseudoscience. Give three examples.<\/li>\n<li>What are some indicators that a claim, belief, or practice might be pseudoscience rather than true science?<\/li>\n<li>Astrology was once considered a science, and it was common in academic circles. Why did its status change from a science to a pseudoscience?<\/li>\n<li>What are possible reasons that some pseudosciences remain popular even after they have been shown to have no scientific validity or explanatory power?<\/li>\n<li>List three other ways besides pseudoscience that science can be misused, and identify an example of each.<\/li>\n<li>Explain how misuses of science may waste money and effort.\u00a0How can they\u00a0potentially cause harm to the public?<\/li>\n<li>Many claims made by pseudoscience cannot be tested with evidence. From a scientific perspective, why is it important that claims be testable?<\/li>\n<li>What do you think is the difference between pseudoscience and belief?<\/li>\n<li>If you see a website that claims that an herbal supplement causes weight loss and they use a lot of scientific terms to explain how it works, can you be assured that the drug is scientifically proven to work? If not, what are some steps you can take to determine whether or not the drug does in fact work?<\/li>\n<li>Why do you think it was problematic that Andrew Wakefield received funding from a group of people who were suing vaccine manufacturers?<\/li>\n<li>What do you think it says about the 1998 Wakefield paper that ten of the 12 coauthors formally retracted their conclusions?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">1.7 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=E91bGT9BjYk<\/p>\n<p style=\"text-align: center\">How to spot a misleading graph - Lea Gaslowitz, TED-Ed, 2017.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=sxYrzzy3cq8<\/p>\n<p style=\"text-align: center\">How statistics can be misleading - Mark Liddell, TED-Ed, 2016.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h3 id=\"x-ck12-YzhkZDM1NjIyZWY2OTkxNDVlODQ3NzVmZGJkNzkyYmY.-wlj\"><strong>Attributions<\/strong><\/h3>\n<p><strong>Figure 1.7.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.maxpixel.net\/Zodiac-Gemini-Aries-Aquarius-Cancer-Signs-Leo-29420\">Zodiac Signs Cancer Aquarius Aries Gemini Leo<\/a> from <a href=\"http:\/\/maxpixel.net\">Max Pixel<\/a>, is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication license (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en).<\/p>\n<p><strong>Figure 1.7.2<\/strong><\/p>\n<p id=\"firstHeading\" class=\"firstHeading\" lang=\"en\"><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Piltdown_Man_-_McGregor_model.jpg\">Piltdown Man - McGregor model<\/a>, by <a href=\"https:\/\/archive.org\/stream\/practicaltreatis00case\/practicaltreatis00case#page\/46\/mode\/2up\">James Howard McGregor<\/a> on Wikimedia Commons is in the <a href=\"https:\/\/commons.wikimedia.org\/wiki\/Commons:Licensing#Material_in_the_public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain)<b>.<\/b><\/p>\n<p><strong>Figure 1.7.3<\/strong><\/p>\n<p id=\"firstHeading\" class=\"firstHeading\" lang=\"en\"><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Sterkfontein_Piltdown_man.jpg\">Sterkfontein Piltdown man<\/a>, by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Anrie\">Anrie <\/a>\u00a0on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license.<\/p>\n<p><strong>Figure 1.7.4<\/strong><\/p>\n<p><a href=\"http:\/\/www.tylervigen.com\/spurious-correlations\">Spurious Correlations (Causation Fallacy) - Consumption of mozzarella cheese and awarded Doctorates<\/a> by Tyler Vigen on <a href=\"http:\/\/tylervigen.com\">Tylervigen.com<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0\/) license.<\/p>\n<p><strong>Figure 1.7.5<\/strong><\/p>\n<p><a href=\"http:\/\/www.tylervigen.com\/spurious-correlations\">Spurious Correlations (Causation Fallacy) - Miss America and Murder<\/a>, by Tyler Vigen, is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0\/) license.<\/p>\n<p><strong>Figure 1.7.6<\/strong><\/p>\n<p><a href=\"https:\/\/www.compoundchem.com\/2014\/04\/02\/a-rough-guide-to-spotting-bad-science\/\">A rough guide to spotting bad science,<\/a> by <a href=\"http:\/\/compoundchem.com\">Compound Interest<\/a>, is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/ca\/\">CC BY-NC-ND 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/ca\/) license<\/p>\n<h3><strong>References<\/strong><\/h3>\n<p class=\"hanging-indent\">TED-Ed. (2017, July 6). How to spot a misleading graph - Lea Gaslowitz. YouTube. https:\/\/www.youtube.com\/watch?v=E91bGT9BjYk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Wakefield, A.J., Murch, S.H., Anthony, A., Linnell, J., Casson, D.M., Malik, M., et al. (1998). Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. <em>Lancet<\/em>, 351: 637\u201341.<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 18). Andrew Wakefield. <i>Wikipedia.<\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Andrew_Wakefield&amp;oldid=963243135<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3953\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3953\"><div tabindex=\"-1\"><p style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em\">Created by:\u00a0CK-12\/Adapted by: Christine Miller<\/p>\n<figure id=\"attachment_37\" aria-describedby=\"caption-attachment-37\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-37\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/vaccine-1-scaled.jpg\" alt=\"1.2.1 Vaccine\" width=\"400\" height=\"269\"><figcaption id=\"caption-attachment-37\" class=\"wp-caption-text\"><em>Figure 1.2.1 Getting vaccinated.<\/em><\/figcaption><\/figure>\n<h1 style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em\"><strong>Ouch!<\/strong><\/h1>\n<p>The person in Figure 1.2.1 is getting a flu vaccine. You probably know that getting a vaccine can hurt \u2014 but it's usually worth it. A vaccine contains dead or altered forms of germs that normally cause a disease, such as flu or measles. The germs in vaccines have been inactivated or weakened so they can no longer cause illness, but are still \"noticed\" by the immune system.<\/p>\n<p>They stimulate the immune system to produce chemicals that can kill the\u00a0<em>actual<\/em>\u00a0germs if they enter the body, thus preventing future disease. How was such an ingenious way to prevent disease discovered? The short answer is more than two centuries of science.<\/p>\n<div>\n<figure id=\"attachment_40\" aria-describedby=\"caption-attachment-40\" style=\"width: 236px\" class=\"wp-caption alignright\"><img class=\"wp-image-40\" title=\"Photo in the Public Domain, from the Centre for Disease Control and Prevention, ID#3265\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Smallpox-1.jpg\" alt=\"A young child in Bangladesh is covered with skin lesions from smallpox. The scarring covers the child's face, including lips and eyelids, as well as the torso and arms.\" width=\"236\" height=\"359\"><figcaption id=\"caption-attachment-40\" class=\"wp-caption-text\"><em>Figure 1.2.2 A young child in Bangladesh is covered with skin lesions from smallpox. Until it was eradicated, this highly contagious infection caused many deaths, and those that survived were often severely scarred for life.<\/em><\/figcaption><\/figure>\n<h1>Science as Process<\/h1>\n<\/div>\n<p>You may think of <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3717\">science<\/a><\/strong> as a large and detailed body of knowledge, but science is also the process by which this knowledge is obtained.\u00a0Science\u00a0uses\u00a0experimentation, evidence, and logic to continuously test ideas. Over time and through repeated experimentation\u00a0and testing, scientific knowledge advances.<\/p>\n<p>We've been accumulating knowledge of vaccines for more than two centuries.\u00a0The discovery of the first vaccine, as well as the process of vaccination, dates back to 1796. An English doctor named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Edward_Jenner\" target=\"_blank\" rel=\"noopener noreferrer\">Edward Jenner<\/a> observed that people who became infected with cowpox did not get sick from smallpox, a similar but much more severe disease (Figure 1.2.2). Jenner decided to transmit cowpox to a young boy to see if it would protect him from smallpox. He gave the boy cowpox by scratching liquid from cowpox sores into the boy's skin. Then, six weeks later, he scratched liquid from smallpox sores into the boy's skin. As Jenner predicted, the boy did not get sick from smallpox. Jenner had discovered the first vaccine, although additional testing was needed to show that it really was effective.<\/p>\n<p>Almost a century passed before the next vaccine was discovered, a vaccine for cholera in 1879. Around the same time, French chemist <a href=\"https:\/\/en.wikipedia.org\/wiki\/Louis_Pasteur\" target=\"_blank\" rel=\"noopener noreferrer\">Louis Pasteur<\/a> found evidence that many human diseases are caused by germs, which earned\u00a0him\u00a0the title of \"father of germ theory.\" Since Pasteur's time, vaccines have been discovered for scores of additional diseases caused by germs, and scientists are currently researching vaccines for many others.<\/p>\n<div>\n<h1>Benefits of Science<\/h1>\n<\/div>\n<p>Medical advances such as the discovery of vaccines are one of the most important benefits of science, but science and scientific knowledge are also crucial for most other human endeavors. Science is needed to design safe cars, predict storms, control\u00a0global warming, develop new technologies of many kinds, help couples have children, and put humans on the moon. Clearly, the diversity of applications of scientific knowledge is vast!<\/p>\n<p>&nbsp;<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">1.2 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Science is a large and detailed body of knowledge. It is also the process by which this knowledge is obtained.<\/li>\n<li>Science\u00a0uses\u00a0experimentation, evidence, and logic to continuously test ideas. Over time and\u00a0through\u00a0repeated experimentation\u00a0and testing, scientific knowledge advances.<\/li>\n<li>Medical advances such as the\u00a0development\u00a0of vaccines are one of the most important benefits of science, but science and scientific knowledge are also crucial for most other human endeavors.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">1.2 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Explain why science is considered both a process\u00a0and\u00a0a body of knowledge.<\/li>\n<li>State three specific examples of human endeavors that are based on scientific knowledge.<\/li>\n<li>How does science influence your daily life?<\/li>\n<li>Jenner used a young boy as a\u00a0research\u00a0subject in his smallpox vaccine research. Today, scientists must follow strict guidelines when using human subjects in their research. What unique concerns do you think might arise when human beings are used as research subjects?<\/li>\n<li>What gave Jenner the idea to develop a vaccine for smallpox?<\/li>\n<li>Why do you think almost a century passed between the\u00a0development\u00a0of the first vaccine (for smallpox) and the development of the next vaccine (for cholera)<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">1.2 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?time_continue=1&amp;amp;v=yqUFy-t4MlQ&amp;amp;feature=emb_logohttps:\/\/www.ted.com\/talks\/uri_alon_why_science_demands_a_leap_into_the_unknown?language=en<\/p>\n<p style=\"text-align: center\">How we conquered the deadly smallpox virus - Simona Zompi, TED-Ed, 2013.<\/p>\n<p class=\"textbox__title\">\n<\/div>\n<\/div>\n<h2 id=\"x-ck12-YzhkZDM1NjIyZWY2OTkxNDVlODQ3NzVmZGJkNzkyYmY.-wlj\"><strong>Attributions<\/strong><\/h2>\n<p><strong>Figure 1.2.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/a1p0Z7RSkL8\">Vacina, centro de vacina\u00e7\u00e3o<\/a>, by <span class=\"_2aPXR\"><a href=\"https:\/\/unsplash.com\/@hyttalosouza\">Hyttalo Souza<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a>, used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).\u00a0<\/span><\/p>\n<p><strong>Figure 1.2.2<\/strong><\/p>\n<p><a href=\"https:\/\/phil.cdc.gov\/details.aspx?pid=3265\">Child with Smallpox\/ID#3265<\/a>, by CDC\/ James Hicks, from the\u00a0Centre for Disease Control and Prevention, is in the <a href=\"https:\/\/commons.wikimedia.org\/wiki\/Commons:Licensing#Material_in_the_public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2><strong>References<\/strong><\/h2>\n<p class=\"hanging-indent\">TED-Ed. (2013, October 28). How we conquered the deadly smallpox virus - Simona Zompi.\u00a0 YouTube. https:\/\/www.youtube.com\/watch?v=yqUFy-t4MlQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, August 9). Edward Jenner. In\u00a0<i>Wikipedia. <\/i>https:\/\/en.wikipedia.org\/w\/index.php?title=Edward_Jenner&amp;oldid=971970576<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, August 5). Louis Pasteur. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Louis_Pasteur&amp;oldid=971330056<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3954\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3954\"><div tabindex=\"-1\"><div>\n<p><span style=\"text-align: initial;font-size: 1em\">Created by:\u00a0CK-12\/Adapted by: Christine Miller<\/span><\/p>\n<p><img class=\"wp-image-41 aligncenter\" title=\"CC0 1.0 Universal (CC0 1.0) from openclipart.org\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Question-Guy-2.png\" alt=\"Clip art of a person thinking with a thought bubble filled with question marks.\" width=\"166\" height=\"184\"><\/p>\n<h1 style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em\"><span style=\"text-align: initial;font-size: 1em\"><span style=\"font-size: 22.784px\">Defining Science<\/span><\/span><\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3717\">Science<\/a><\/strong>\u00a0is a distinctive way of gaining knowledge about the natural world that starts with a question and then tries to answer the question\u00a0using\u00a0evidence and logic.\u00a0It\u00a0is an exciting exploration of all the whys and hows that any curious person might\u00a0ask\u00a0about the world. You can be part of that exploration! Besides your curiosity, all you need is a basic understanding of how scientists think and how <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3717\">science<\/a> is done. In this concept, you'll learn how to think like a scientist.<\/p>\n<h2><span style=\"font-size: 1em;font-weight: bold\">Thinking Like a Scientist<\/span><\/h2>\n<p>Thinking like a scientist rests on certain underlying assumptions. Scientists assume that:<\/p>\n<p>&nbsp;<\/p>\n<div><img class=\"aligncenter wp-image-1856\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Thinking-like-a-scientist-1.png\" alt=\"\" width=\"300\" height=\"300\"><\/div>\n<h2>Nature Is\u00a0Understandable<\/h2>\n<p>Scientists think of nature as a single system controlled by natural laws. By discovering natural laws, scientists strive to increase their understanding of the natural world. Laws of nature are expressed as scientific laws. A\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3561\">scientific law<\/a><\/strong>\u00a0is a statement that describes what always happens under certain conditions in nature.<\/p>\n<h2>Scientific Ideas Are Open to\u00a0Change<\/h2>\n<p>Science is\u00a0both\u00a0a process\u00a0and\u00a0body of knowledge.\u00a0Scientific knowledge is generated through systematic processes, such as\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3557\"><strong>observation<\/strong><\/a>\u00a0and experimentation.\u00a0Scientists are always testing and revising their ideas, and as new observations are made, existing ideas may be challenged. Ideas may be replaced with new ideas that better fit the facts, but more often, existing ideas are simply revised. Through many new discoveries over time, scientists gradually build an increasingly accurate and detailed understanding of the natural world.<\/p>\n<h2>Scientific Knowledge May Be Long Lasting<\/h2>\n<p>Many scientific ideas have\u00a0stood\u00a0the test of time. About 200 years ago, the scientist <a href=\"https:\/\/en.wikipedia.org\/wiki\/John_Dalton\">John Dalton<\/a> proposed atomic theory \u2014 the theory that all matter is made of tiny particles called atoms. This theory is still valid today. During the two centuries since the theory was first proposed,\u00a0scientists have\u00a0learned a lot more about atoms and the even smaller particles\u00a0that compose them. Nonetheless, the idea that all matter consists of atoms remains valid. There are many other examples of basic\u00a0scientific\u00a0ideas that have been tested repeatedly and proven sound. You will learn about many of them as you study human biology.<\/p>\n<h2>Not All Questions Can be Answered by Science<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3717\">Science<\/a><\/strong> rests on evidence and logic, and evidence comes from observations. Therefore, science deals only with things that can be observed. An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3557\">observation<\/a><\/strong>\u00a0is anything that is detected through human\u00a0senses\u00a0or with instruments or\u00a0measuring devices that extend human\u00a0senses. Things that cannot be observed or measured by\u00a0current\u00a0means \u2014 such as supernatural beings or events \u2014 are outside the bounds of science. Consider these two questions about life on Earth:<\/p>\n<ul>\n<li>Did life on Earth evolve over time?<\/li>\n<li>How did life on Earth originate?<\/li>\n<\/ul>\n<p>The first question can be answered by science on the basis of scientific evidence (such as\u00a0fossils\u00a0and logical arguments). The second question could be a matter of belief, but no evidence can be gathered to support or refute it. Therefore, it is outside the realm of science.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">1.3 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Science is a distinctive way of gaining knowledge about the natural world that tries to answer questions\u00a0using\u00a0evidence and logic.<\/li>\n<li>Scientists assume that nature can be understood\u00a0through systematic study.<\/li>\n<li>Scientific ideas are open to revision.<\/li>\n<li>Sound scientific ideas withstand the test of time.<\/li>\n<li>Science cannot provide answers to all of our questions.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">1.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Define science.<\/li>\n<li>What is the general goal of science?<\/li>\n<li>\n<div id=\"h5p-46\">\n<div class=\"h5p-content\" data-content-id=\"46\"><\/div>\n<\/div>\n<\/li>\n<li>Identify four basic assumptions that scientists make when they study the natural world.<\/li>\n<li>Do observations in science have to be made by the naked eye? Can you think of a way in which scientists might be able to make observations about something they cannot directly see?<\/li>\n<li>If something cannot be observed, can it be tested scientifically? Explain your reasoning.<\/li>\n<li>Scientific knowledge builds upon itself. Give an example of a scientific idea from the reading where the initial idea\u00a0developed further\u00a0as science advanced.<\/li>\n<li>Discuss this statement: \u201cScientific ideas are always changing, so they can't be trusted.\u201d Do you think this is true?<\/li>\n<li>Why do you think that scientific knowledge expands as technology becomes more advanced?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\">1.3 Explore More<\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/3nAETHZTObk<\/p>\n<p style=\"text-align: center\">Nature of Science with the Ameoba Sisters, 2019.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<div>\n<h2><strong>References<\/strong><\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2019, Jun 6). Nature of science with Ameoba Sisters. YouTube. https:\/\/www.youtube.com\/watch?v=3nAETHZTObk<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, July 25). John Dalton. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=John_Dalton&amp;oldid=969425891<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3975\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3975\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<p>After reading this chapter, you should be able to see numerous connections between chemistry, human life, and health. In Joseph\u2019s situation, chemistry is involved in the reasons why his father has diabetes, why his personal risk of getting diabetes is high, and why the dietary changes he is considering could be effective.<\/p>\n<figure id=\"attachment_1376\" aria-describedby=\"caption-attachment-1376\" style=\"width: 504px\" class=\"wp-caption alignleft\"><img class=\" wp-image-1376\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Prevalence_of_Diabetes_by_Percent_of_Country_Population_2014_Gradient_Map-1.png\" alt=\"Diagram shows a map of places in the world where diabetes is most prevalent. Northern Africa and the Middle East have high prevalence and South East Africa has low prevalence.\" width=\"504\" height=\"275\"><figcaption id=\"caption-attachment-1376\" class=\"wp-caption-text\"><em>Figure 3.13.1. Prevalence of diabetes by per cent of country population.<\/em><\/figcaption><\/figure>\n<p>Type 2 diabetes affects populations worldwide and is caused\u00a0primarily\u00a0by a lack of response in the body to the hormone insulin, which causes problems in the regulation of blood sugar, or glucose. Insulin is a peptide hormone, and as you have learned, peptides are chains of amino acids. Therefore, insulin is in the class of biochemical compounds called proteins. Joseph is at increased risk of diabetes partly because there is a genetic component to the disease. DNA, which is a type of chemical compound called a nucleic acid, is passed down from parents to their offspring, and carries the instructions for the production of proteins in units called genes. If there is a problem in a gene (or genes) that contributes to the development of a disease, such as type 2 diabetes, this can get passed down to the offspring and may raise that child\u2019s risk of getting the disease.<\/p>\n<p>But genetics is only part of the reason why Joseph is at an increased risk of diabetes. Obesity itself is a risk factor, and one that can be shared in families due to shared lifestyle factors (such as poor diet and lack of exercise), as well as\u00a0genetics. Consumption of too many refined carbohydrates (like white bread and soda) may also contribute to obesity and the development of diabetes. As you probably now know, these simple carbohydrates are more easily and quickly broken down in the digestive system into glucose than larger complex carbohydrate molecules, such as those found in vegetables and whole grains. This can lead to dramatic spikes in blood sugar levels, which is particularly problematic for people with diabetes because they have trouble maintaining their blood sugar at a safe level. You can understand why Joseph\u2019s father limits his consumption of refined carbohydrates, and in fact, some scientific studies have shown that avoiding refined carbohydrates may actually help reduce the risk of getting diabetes in the first place.<\/p>\n<figure id=\"attachment_1377\" aria-describedby=\"caption-attachment-1377\" style=\"width: 305px\" class=\"wp-caption alignright\"><img class=\" wp-image-1377\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Healthy-meal-1.jpg\" alt=\"Image shows a plate of food containing a salad, fish and broccoli.\" width=\"305\" height=\"305\"><figcaption id=\"caption-attachment-1377\" class=\"wp-caption-text\"><em>Figure 3.13.2. A diet high in vegetables and lean meats can help reduce the risk of Type 2 Diabetes.<\/em><\/figcaption><\/figure>\n<p>Joseph\u2019s friend recommended eating a low fat, high carbohydrate diet to lose weight, but you can see that\u00a0the\u00a0<em>type<\/em> of carbohydrate \u2014 simple or complex \u2014 is an important consideration. Eating a large amount of white bread and rice may not help Joseph reduce his risk of diabetes, but a healthy diet that helps him lose weight may lower his risk of diabetes, since obesity itself is a factor. Which specific diet will work best to help him lose weight probably depends on a variety of factors, including his biology, lifestyle, and food preferences. Joseph should consult with his doctor about his diet and exercise plan, so that his specific situation can be taken into account and monitored by a medical professional.<\/p>\n<p>Drinking enough water is usually good advice for everyone, especially if it replaces sugary drinks like soda. You now know that water is important for many of the chemical reactions that take place in the body. But you can have too much of a good thing \u2014 as in the case of marathon runners who can make themselves sick from drinking too much water! As you can see, proper balance, or homeostasis, is very important to the health of living organisms.<\/p>\n<p>Finally, you probably now realize that \u201cchemicals\u201d do not have to be scary, toxic substances. All matter consists of chemicals, including water, your body, and healthy fresh fruits and vegetables, like the ones pictured in Figure 3.12.2. When people advocate \u201cclean eating\u201d and avoiding \u201cchemicals\u201d in food, they are usually referring to avoiding synthetic \u2014 or man-made \u2014 chemical additives, such as preservatives. This can be a healthy way to eat because it involves eating a variety of whole, fresh, unprocessed foods. But there is no reason to be scared of chemicals in general \u2014 they are simply molecules and how they react depends on what they are, what other molecules are present, and the environmental conditions surrounding them.<\/p>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\">Chapter 3 Summary<\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>By now, you should have a good understanding of the basics of the chemistry of life. Specifically, you have learned:<\/p>\n<ul>\n<li>All <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3543\">matter<\/a> consists of chemical substances. A chemical substance has a definite and consistent composition and may be either an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3655\">element<\/a> or a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3641\">compound<\/a>.<\/li>\n<li>An <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3655\">element<\/a> is a pure substance that cannot be broken down into other types of substances.\n<ul>\n<li>An <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3619\">atom<\/a> is the smallest particle of an element that still has the properties of that element. Atoms, in turn, are composed of subatomic particles, including negative <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3659\">electrons<\/a>, positive <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3731\">protons<\/a>, and neutral <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_1365\">neutrons<\/a>. The number of protons in an atom determines the element it represents.<\/li>\n<li>Atoms have equal numbers of electrons and protons, so they have no charge. Ions are atoms that have lost or gained electrons, so they have either a positive or negative charge. Atoms with the same number of protons but different numbers of neutrons are called isotopes.<\/li>\n<li>There are almost 120 known elements. The majority of elements are metals. A smaller number are nonmetals, including carbon, hydrogen, and oxygen.<\/li>\n<\/ul>\n<\/li>\n<li>A <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3641\">compound<\/a> is a substance that consists of two or more elements in a unique composition. The smallest particle of a compound is called a molecule. Chemical bonds hold together the atoms of molecules. Compounds can form only in chemical reactions, and they can break down only in other chemical reactions.\n<ul>\n<li>Biochemical compounds are carbon-based compounds found in living things. They make up <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3573\">cells<\/a>\u00a0and other structures of organisms and carry out life processes. Most biochemical compounds are large molecules called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3713\">polymers<\/a>\u00a0that consist of many repeating units of smaller molecules called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3689\">monomers<\/a>.<\/li>\n<li>There are millions of different biochemical compounds, but all of them fall into four major classes: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3563\">carbohydrates<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3559\">lipids<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3721\">proteins<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3383\">nucleic acids<\/a>.<\/li>\n<\/ul>\n<\/li>\n<li>Carbohydrates are the most common class of biochemical compounds. They provide cells with energy, store energy, and make up organic structures, such as the cell walls of plants. The basic building block of carbohydrates is the monosaccharide.\n<ul>\n<li>Sugars are short-chain carbohydrates that supply us with energy. Simple sugars, such as glucose, consist of just one monosaccharide. Some sugars, such as sucrose (or table sugar) consist of two monosaccharides and are called disaccharides.<\/li>\n<li>Complex carbohydrates, or polysaccharides, consist of hundreds or even thousands of monosaccharides. They include starch, glycogen, cellulose, and chitin.\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3367\">Starch<\/a> is made by plants to store energy and is readily broken down into its component sugars during digestion.<\/li>\n<li>Glycogen is made by animals and fungi to store energy and plays a critical part in the homeostasis of blood glucose levels in humans.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_333\">Cellulose<\/a> is the most common biochemical compound in living things. It forms the cell walls of plants and certain algae. Humans cannot digest cellulose, but it makes up most of the crucial dietary fibre in the human diet.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_335\">Chitin<\/a> makes up organic structures, such as the cell walls of fungi and the exoskeletons of insects and other arthropods.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>Lipids include fats and oils. They store energy, form cell membranes, and carry messages.\n<ul>\n<li>Lipid molecules consist mainly of repeating units called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3565\">fatty acids<\/a>. Fatty acids may be <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3601\">saturated<\/a> or <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3593\">unsaturated<\/a>, depending on the proportion of hydrogen atoms they contain. Animals store fat as saturated fatty acids, while plants store fat as unsaturated fatty acids.<\/li>\n<li>Types of lipids include triglycerides, phospholipids, and steroids.\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3587\">Triglycerides <\/a>contain glycerol (an alcohol) in addition to fatty acids. Humans and other animals store fat as triglycerides in fat cells.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_368\">Phospholipids<\/a> contain phosphate and glycerol in addition to fatty acids. They are the main component of cell membranes in all living things.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_375\">Steroids<\/a> are lipids with a four-ring structure. Some steroids, such as cholesterol, are important components of cell membranes. Many other steroids are hormones.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>In living things, proteins include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3665\">enzymes<\/a>, antibodies, and numerous other important compounds. They\u00a0help\u00a0cells keep their shape, make up muscles, speed up chemical reactions, and carry messages and materials (among other functions).\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3721\">Proteins<\/a> are made up of small monomer molecules called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3615\">amino acids<\/a>.<\/li>\n<li>Long chains of amino acids form polypeptides. The sequence of amino acids in polypeptides makes up the primary structure of proteins. Secondary structure refers to configurations such as helices and sheets within polypeptide chains. Tertiary structure is a protein's overall three-dimensional shape, which controls the molecule's basic function. A quaternary structure forms if multiple protein molecules join together and function as a complex.<\/li>\n<li>The chief characteristic that allows proteins' diverse functions is their ability to bind specifically and tightly with other molecules.<\/li>\n<\/ul>\n<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3383\">Nucleic acids<\/a> include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_277\">DNA<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_519\">RNA<\/a>. They encode instructions for making proteins, helping make proteins, and passing the encoded instructions from parents to offspring.\n<ul>\n<li>Nucleic acids are built of monomers called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_518\">nucleotides<\/a>, which bind together in long chains to form polynucleotides. DNA consists of two polynucleotides, and RNA consists of one polynucleotide.<\/li>\n<li>Each nucleotide consists of a sugar molecule, phosphate group, and nitrogen base. Sugars and phosphate groups of adjacent nucleotides bind together to form the \"backbone\" of the polynucleotide. Bonds between complementary bases hold together the two polynucleotide chains of DNA and cause it to take on its characteristic double helix shape.<\/li>\n<li>DNA makes up genes, and the sequence of nitrogen bases in DNA makes up the genetic code for the synthesis of proteins. RNA helps synthesize proteins in cells. The genetic code in DNA is also passed from parents to offspring during reproduction, explaining how inherited characteristics are passed from one generation to the next.<\/li>\n<\/ul>\n<\/li>\n<li>A <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3637\">chemical reaction<\/a> is a process that changes some chemical substances into others. A substance that starts a chemical reaction is called a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3409\">reactant<\/a>, and a substance that forms in a chemical reaction is called a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3411\">product<\/a>. During the chemical reaction, bonds break in reactants and new bonds form in products.<\/li>\n<li>Chemical reactions can be represented by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3415\">chemical equations<\/a>. According to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3417\">law of conservation of mass<\/a>, mass is always conserved in a chemical reaction, so a chemical equation must be balanced, with the same number of atoms of each type of element in the products as in the reactants.<\/li>\n<li>Many chemical reactions occur all around us each day, such as iron rusting and organic matter rotting, but not all changes are chemical processes. Some changes, such as ice melting or paper being torn into smaller pieces, are physical processes that do not involve chemical reactions and the formation of new substances.<\/li>\n<li>All chemical reactions involve energy, and\u00a0they require\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3427\">activation energy<\/a> to begin. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3421\">Exothermic reactions<\/a>\u00a0release energy. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3425\">Endothermic reactions<\/a>\u00a0absorb energy.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3581\">Biochemical reactions<\/a>\u00a0are chemical reactions that take place inside living things. The sum of all the biochemical reactions in an organism is\u00a0called\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3681\">metabolism<\/a>. Metabolism includes catabolic reactions (exothermic reactions) and anabolic reactions (endothermic reactions).<\/li>\n<li>Most biochemical reactions\u00a0require\u00a0a biological <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3577\">catalyst<\/a> called an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3665\">enzyme<\/a> to speed up the reaction by reducing the amount of activation energy needed for the reaction to begin. Most enzymes are proteins that affect just one specific substance, called the enzyme's substrate.<\/li>\n<li>Virtually all living things on Earth require liquid water. Only a tiny per cent of Earth's water is fresh liquid water. Water exists as a liquid over a wide range of temperatures, and it dissolves many substances. These properties depend on water's polarity, which causes water molecules to \"stick\" together through weak bonds called hydrogen bonds.<\/li>\n<li>The human body is about 70 per cent water (outside of fat). Organisms need water to dissolve many substances and for most biochemical processes, including photosynthesis and cellular respiration.<\/li>\n<li>A solution is a mixture of two or more substances that has the same composition throughout. Many solutions consist of water and one or more dissolved substances.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3375\">Acidity<\/a> is a measure of the hydronium ion concentration in a solution. Pure water has a very low concentration and a pH of 7, which is the point of neutrality on the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3709\">pH scale<\/a>. Acids have a higher hydronium ion concentration than pure water and a pH lower than 7. Bases have\u00a0a lower hydronium ion concentration than pure water and a pH higher than 7.<\/li>\n<li>Many acids and bases in living things are secreted to provide the proper pH for enzymes to work properly.<\/li>\n<\/ul>\n<p>Now you understand the chemistry of the molecules that make up living things. In the next chapter, you will learn how these molecules make up the basic unit of structure and function in living organisms \u2014 cells \u2014 and you will be able to understand some of the crucial chemical reactions that occur within cells.<\/p>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\">Chapter 3 Review<\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-54\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-54\" class=\"h5p-iframe\" data-content-id=\"54\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Cell biology True or False\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>The chemical formula for the complex carbohydrate glycogen is C<sub>24<\/sub>H<sub>42<\/sub>O<sub>21<\/sub>.\n<ol type=\"a\">\n<li>What are the elements in glycogen?<\/li>\n<li>How many atoms are in one molecule of glycogen?<\/li>\n<li>Is glycogen an ion? Why or why not?<\/li>\n<li>Is glycogen a monosaccharide or a polysaccharide? Besides memorizing this fact, how would you know this based on the information in the question?<\/li>\n<li>What is the function of glycogen in the human body?<\/li>\n<\/ol>\n<\/li>\n<li>What is the difference between an ion and a polar molecule? Give an example of each in your explanation.<\/li>\n<li>Define monomer and polymer.<\/li>\n<li>\n<div id=\"h5p-54\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-54\" class=\"h5p-iframe\" data-content-id=\"54\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Cell biology True or False\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What is the difference between a protein and a polypeptide?<\/li>\n<li>\n<div id=\"h5p-56\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-56\" class=\"h5p-iframe\" data-content-id=\"56\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Linkage Map for Human X Chromosome\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>People with diabetes have trouble controlling the level of glucose in their bloodstream. Knowing this, why do you think it is often recommended that people with diabetes limit their consumption of carbohydrates?<\/li>\n<li>Identify each of the following reactions as endothermic or exothermic.\n<ol type=\"a\">\n<li>cellular respiration<\/li>\n<li>photosynthesis<\/li>\n<li>catabolic reactions<\/li>\n<li>anabolic reactions<\/li>\n<\/ol>\n<\/li>\n<li>Pepsin is an enzyme in the stomach that helps us digest protein. Answer the following questions about pepsin:\n<ol type=\"a\">\n<li>What is the substrate for pepsin?<\/li>\n<li>How does pepsin work to speed up protein digestion?<\/li>\n<li>Given what you know about the structure of proteins, what do you think are some of the products of the reaction that pepsin catalyzes?<\/li>\n<li>The stomach is normally acidic. What do you think would happen to the activity of pepsin and protein digestion if the pH is raised significantly?<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 3.13.1<\/strong><\/p>\n<section class=\"standard post-459 chapter type-chapter status-publish hentry focusable\" data-type=\"chapter\">\n<div class=\"media-atttributions\">\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Prevalence_of_Diabetes_by_Percent_of_Country_Population_(2014)_Gradient_Map.png\" rel=\"cc:attributionURL\">Prevalence_of_Diabetes_by_Percent_of_Country_Population_(2014)_Gradient_Map<\/a> by Walter Scott Wilkens [<a class=\"new\" title=\"Wwilken2 (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=Wwilken2&amp;action=edit&amp;redlink=1\">Wwilken2<\/a>], University of Illinois - Urbana Champaign Department of Geography and GIScience, on Wikimedia Commons, is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 3.13.2<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/melystu\/30565936328\" rel=\"cc:attributionURL\">Healthy plate<\/a> by <a class=\"owner-name truncate\" title=\"Go to Melinda Young Stuart's photostream\" href=\"https:\/\/www.flickr.com\/photos\/melystu\/\" data-track=\"attributionNameClick\">Melinda Young Stuart<\/a> on Flickr is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/\">CC BY-NC-ND 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/) license.<\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3958\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3958\"><div tabindex=\"-1\"><p>Created by CK-12\/Adapted by Christine Miller<\/p>\n<h1 style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em\">Case Study: Our Invisible Inhabitants<\/h1>\n<figure id=\"attachment_104\" aria-describedby=\"caption-attachment-104\" style=\"width: 200px\" class=\"wp-caption alignleft\"><img class=\"wp-image-104 size-medium\" style=\"color: #373d3f;font-weight: bold;font-size: 1em\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Sick-patient-1.jpg\" alt=\"\" width=\"200\" height=\"300\"><figcaption id=\"caption-attachment-104\" class=\"wp-caption-text\"><em>Figure 2.1.1 Lanying has the flu. Can she stop taking her antibiotics once she starts feeling better?<\/em><\/figcaption><\/figure>\n<p>Lanying is suffering from a fever, body aches, and a painful sore throat\u00a0that\u00a0feels\u00a0worse when she swallows. She visits her doctor, who examines her and performs a throat culture. When the results come back, he tells her that she has strep throat, which is caused by the bacteria\u00a0<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/strep-throat\/symptoms-causes\/syc-20350338\" target=\"_blank\" rel=\"noopener noreferrer\">Streptococcus\u00a0pyogenes<\/a>. He prescribes an antibiotic\u00a0that will either\u00a0kill the bacteria or\u00a0stop it\u00a0from reproducing, and advises her to take the full course of the treatment even if she is feeling better earlier. Stopping early can cause an increase in bacteria that are resistant to antibiotics.<\/p>\n<div>\n<div class=\"mceTemp\"><\/div>\n<\/div>\n<p>Lanying takes the antibiotic as prescribed. Toward the end of the course, her throat is feeling much better \u2014 but she can\u2019t say the same for other parts of her body! She has developed diarrhea and an itchy vaginal yeast infection. She calls her doctor, who suspects that the antibiotic treatment has caused\u00a0both the\u00a0digestive distress and\u00a0the\u00a0yeast infection. He explains that our bodies are home to many different kinds of microorganisms, some of which are actually\u00a0beneficial\u00a0to us because they help us digest our food\u00a0and\u00a0minimize\u00a0the population of harmful microorganisms. When we take an antibiotic, many of these \u201cgood\u201d bacteria are killed along with the \u201cbad,\u201d disease-causing bacteria, which can result in diarrhea and yeast infections.<\/p>\n<p>Lanying's doctor\u00a0prescribes an antifungal medication for\u00a0her\u00a0yeast infection. He also recommends that she eat yogurt with live cultures, which will help replace the beneficial bacteria in her gut. Our bodies contain a delicate balance of inhabitants that are invisible without a microscope, and changes in that balance can cause unpleasant health effects.<\/p>\n<div>\n<h1>What Is Human Biology?<\/h1>\n<\/div>\n<p><span style=\"text-align: initial;font-size: 1em\">As you read the rest of this book, you'll learn more amazing facts about the human organism,\u00a0and you'll get a better sense of\u00a0how biology relates to your health.\u00a0Human biology\u00a0is the scientific study of the human species, which includes the fascinating story of human evolution and a detailed account of our genetics, anatomy, physiology, and ecology. In short,\u00a0the study\u00a0focuses on how we got here, how we function, and the role we play in the natural world. This helps us to better understand human health, because we can learn how to stay healthy and how diseases and injuries can be treated.\u00a0Human biology\u00a0should be\u00a0of personal interest to you\u00a0to the extent that it can benefit\u00a0your own health, as well as the health of your friends and family. This branch of science also has broader implications for society and the human species as a whole.<\/span><\/p>\n<div class=\"textbox shaded\">\u00a0As you continue reading, think about what you want to learn about your own body. What questions or concerns do you have? Make a list of them and use it to guide your study of human biology. You can revisit the list throughout the course to see if your questions have been answered. If not, you'll have the tools you need to find the answers. You will have learned how to find sources of information about human biology, and you'll be able to judge which sources are most reliable.<\/div>\n<p>&nbsp;<\/p>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter Overview: Living Organisms and Human Biology<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In the rest of this chapter, you'll learn about the traits shared by all living things, the basic principles that underlie all of biology, the vast diversity of living organisms, what it means to be human, and our place in the animal kingdom. Specifically, you'll learn:<\/p>\n<ul>\n<li>The seven traits shared by all living things: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3669\"><strong>homeostasis<\/strong>,<\/a> or the maintenance of a more-or-less constant internal environment; multiple levels of organization consisting of one or more <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3573\"><strong>cells<\/strong><\/a>; the use of energy and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3681\"><strong>metabolism<\/strong><\/a>; the ability to grow and develop; the ability to evolve adaptations to the environment; the ability to detect and respond to environmental stimuli; and the ability to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3715\"><strong>reproduce<\/strong><\/a>.<\/li>\n<li>The basic principles that unify all fields of biology, including gene theory, homeostasis, and evolutionary theory.<\/li>\n<li>The diversity of life (including the different kinds of biodiversity), the definition of a species, the classification and naming systems for living organisms, and how evolutionary relationships can be represented through diagrams, such as phylogenetic trees.<\/li>\n<li>How the human species is classified and how we've evolved from our close relatives and ancestors.<\/li>\n<li>The physical traits and social behaviors that humans share with other primates.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div><\/div>\n<div class=\"textbox shaded\">\n<p style=\"text-align: start\">As you read this chapter, consider\u00a0the following questions about Lanying's situation:<\/p>\n<ol style=\"margin-top: 1.42857em;margin-bottom: 1.42857em\">\n<li>What do single-celled organisms (such as the bacteria and yeast living in and on Lanying) have in common with humans?<\/li>\n<li>How are bacteria, yeast, and humans classified?<\/li>\n<li>How do the concepts of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3669\">homeostasis<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3627\">biodiversity<\/a> apply to Lanying\u2019s situation?<\/li>\n<li>Why can stopping antibiotics early cause the development of antibiotic-resistant bacteria?<\/li>\n<\/ol>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attribution<\/h2>\n<p><strong>Figure 2.1.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/oidJ1WGkIeY\">Photo (face mask)<\/a> by <a href=\"https:\/\/unsplash.com\/@fifthperspective\">Michael Amadeus<\/a>, on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash license<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<h2>Reference<\/h2>\n<p class=\"hanging-indent\">Mayo Clinic Staff (n.d.). Strep throat [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/strep-throat\/symptoms-causes\/syc-20350338<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3964\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3964\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<h1 style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em\"><span style=\"font-size: 1.424em\">What Are You Made of?<\/span><\/h1>\n<figure id=\"attachment_250\" aria-describedby=\"caption-attachment-250\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img class=\"wp-image-250 size-medium\" style=\"color: #373d3f;font-weight: bold;font-size: 1em\" title=\" Arawalk Cay, The Bahamas, by Gregory Culmer, on Unsplash, is used under the Unsplash license\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Man-sitting-1.jpg\" alt=\"\" width=\"300\" height=\"199\"><figcaption id=\"caption-attachment-250\" class=\"wp-caption-text\"><em>Figure 3.2.1 What are we?<\/em><\/figcaption><\/figure>\n<p>Your entire body is made of cells and cells are made of molecules.If you look at your hand, what do you see? Of course, you see skin, which consists of <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3573\">cells<\/a><\/strong>. But what are skin cells\u00a0<em>made<\/em>\u00a0of? Like all living\u00a0cells, they are made of matter. In fact,\u00a0<em>all<\/em>\u00a0things are made of matter.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3543\">Matter<\/a><\/strong>\u00a0is anything that takes up space and has mass. Matter, in turn, is made up of chemical substances. A\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3639\">chemical substance<\/a><\/strong>\u00a0is matter that has a definite\u00a0composition\u00a0that is\u00a0consistent\u00a0throughout. A chemical substance may be either an\u00a0element\u00a0or a\u00a0compound.<\/p>\n<h1>Elements and Atoms<\/h1>\n<p>An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3655\">element<\/a><\/strong>\u00a0is a\u00a0pure substance. It cannot be broken down into other types of substances. Each\u00a0element\u00a0is made up of just one type of\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3619\">atom<\/a><\/strong>.<\/p>\n<h2>Structure of an\u00a0Atom<\/h2>\n<figure id=\"attachment_253\" aria-describedby=\"caption-attachment-253\" style=\"width: 226px\" class=\"wp-caption alignright\"><img class=\"wp-image-253\" title=\"Lithium Atom diagram, by AG Caesar, is used under a CC BY-SA 4.0 International license\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Atom-diagram-1.png\" alt=\"Diagram of a lithium atom. Three protons and four neutrons are in the nucleus, and three electrons are orbiting the nucleus.\" width=\"226\" height=\"226\"><figcaption id=\"caption-attachment-253\" class=\"wp-caption-text\"><em>Figure 3.2.2 An atom consists of three subatomic components: protons, neutrons and electrons.<\/em><\/figcaption><\/figure>\n<p>An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3619\">atom<\/a><\/strong> is the smallest particle of an element that still has the properties of that element. Every substance is composed of atoms. Atoms are extremely small, typically about a ten-billionth of a metre in diametre. However, atoms <em>do not<\/em> have well-defined boundaries, as suggested by the atomic model shown\u00a0below.<\/p>\n<div>\n<p><span style=\"text-align: initial;font-size: 1em\">Every <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3619\">atom<\/a><\/strong> is composed of a central area \u2014 called the\u00a0<\/span><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3625\">nucleus<\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0\u2014 and one or more subatomic particles called <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3659\">electrons<\/a><\/strong>, which move around the nucleus. The nucleus\u00a0<\/span><em style=\"text-align: initial;font-size: 1em\">also<\/em><span style=\"text-align: initial;font-size: 1em\">\u00a0consists of subatomic particles. It contains one or more <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3731\">proton<\/a><\/strong>s and typically a similar number of <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3703\">neutrons<\/a><\/strong>. The number of protons in the\u00a0<\/span>nucleus<span style=\"text-align: initial;font-size: 1em\">\u00a0determines the type of element an atom represents. An atom of hydrogen, for example, contains just one\u00a0<\/span>proton<span style=\"text-align: initial;font-size: 1em\">. Atoms of the same element may have different numbers of neutrons in the nucleus. Atoms of the same element with the same number of protons \u2014 but different numbers of neutrons \u2014 are called\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3675\">isotopes<\/a>.<\/strong><\/p>\n<\/div>\n<p>Protons have a positive electric charge and neutrons have no electric charge. Virtually all of an atom's mass is in the protons and neutrons in the\u00a0nucleus. Electrons surrounding the nucleus have almost no mass,\u00a0as well as\u00a0a negative electric charge. If the number of protons and electrons in an atom are equal, then an atom is electrically neutral, because the positive and negative charges cancel each other out. If an atom has more or fewer electrons than protons, then it has an overall negative or positive charge, respectively, and it is called an\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3673\">ion<\/a><\/strong><strong>.<\/strong><\/p>\n<p>The negatively-charged electrons of an atom are attracted to the positively-charged protons in the nucleus by a force called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3653\">electromagnetic force<\/a>,<\/strong>\u00a0for which opposite charges attract. Electromagnetic force between protons in the nucleus causes these subatomic particles to repel each other, because they have the same charge. However, the protons and neutrons in the nucleus are attracted to each other by a different force, called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3695\">nuclear force<\/a>,<\/strong>\u00a0which is usually stronger than the electromagnetic force. Nuclear force repels the positively-charged protons from each other.<\/p>\n<h2>Periodic Table of the Elements<\/h2>\n<p>There are almost 120 known elements. As you can see in the Periodic Table of the Elements shown\u00a0below, the majority of elements are\u00a0metals. Examples of metals are iron (Fe) and copper (Cu). Metals are shiny and good conductors of electricity and\u00a0heat. Nonmetal elements are far fewer in number. They include hydrogen (H) and oxygen (O). They lack the properties of metals.<\/p>\n<div>\n<p>\u00a0The periodic table of the elements arranges elements in groups based on their properties. The element most important to life is carbon (C). Find carbon in the table. What type of element is it: metal or nonmetal?<\/p>\n<\/div>\n<div>\n<figure id=\"attachment_259\" aria-describedby=\"caption-attachment-259\" style=\"width: 573px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-259\" title=\"Periodic Table Armtuk3 by Armtuk, is used under CC BY-SA 3.0 license.\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Periodic-table-1.png\" alt=\"The Periodic Table of Elements\" width=\"573\" height=\"470\"><figcaption id=\"caption-attachment-259\" class=\"wp-caption-text\"><em>Figure 3.2.3 The Periodic Table of Elements.<\/em><\/figcaption><\/figure>\n<h2>Compounds and Molecules<\/h2>\n<\/div>\n<p>A\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3641\">compound<\/a><\/strong>\u00a0is a unique substance that consists of two or more elements combined in fixed proportions. This means that the\u00a0composition\u00a0of a\u00a0compound\u00a0is always the same. The smallest particle of most compounds in living things is called a\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3687\">molecule<\/a>.<\/strong><\/p>\n<figure id=\"attachment_285\" aria-describedby=\"caption-attachment-285\" style=\"width: 256px\" class=\"wp-caption alignright\"><img class=\"wp-image-285 size-full\" title=\"Water molecule, by Sakurambo, is released into the public domain.\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Water-molecule-1-1.png\" alt=\"Image shows a model of a water molecule. A large central oxygen atom is connected to two adjacent, smaller white hydrogen atoms.\" width=\"256\" height=\"184\"><figcaption id=\"caption-attachment-285\" class=\"wp-caption-text\"><em>Figure 3.2.4 A molecule of water consists of one atom of oxygen and two atoms of hydrogen connected by covalent bonds.<\/em><\/figcaption><\/figure>\n<p>Consider\u00a0water\u00a0as an example. A molecule of water always contains one atom of oxygen and two atoms of hydrogen. The\u00a0composition\u00a0of water is expressed by the\u00a0chemical formula\u00a0H<sub>2<\/sub>O. A model of a water molecule is shown in Figure 3.2.4.<\/p>\n<p>What causes the atoms of a\u00a0water\u00a0molecule to \u201cstick\u201d together? The answer is\u00a0<em>chemical bonds<\/em>. A\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3635\">chemical bond<\/a><\/strong>\u00a0is a force that holds together the atoms of molecules. Bonds in molecules involve the sharing of electrons among atoms. New\u00a0chemical bonds\u00a0form when substances react with one another. A\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3637\">chemical reaction<\/a><\/strong>\u00a0is a process that changes some chemical substances into others. A\u00a0chemical reaction\u00a0is needed to form a compound, and another chemical reaction is needed to separate the substances in that compound.<\/p>\n<p>&nbsp;<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">3.2 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>All <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3543\"><strong>matter<\/strong><\/a> consists of chemical substances. A <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3639\"><strong>chemical substance<\/strong><\/a> has a definite composition\u00a0which is consistent\u00a0throughout. A chemical substance may be either an element or a compound.<\/li>\n<li>An <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3655\"><strong>element<\/strong><\/a> is a\u00a0pure substance\u00a0that cannot be broken down into other types of substances.<\/li>\n<li>An <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3619\"><strong>atom<\/strong><\/a> is the smallest particle of an element that still has the properties of that element. Atoms, in turn, are composed of subatomic particles, including negative <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3659\"><strong>electrons<\/strong><\/a>, positive <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3731\"><strong>protons<\/strong><\/a>, and neutral <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3703\"><strong>neutrons<\/strong><\/a>. The number of protons in an atom determines the element it represents.<\/li>\n<li>Atoms have equal numbers of electrons and protons, so they have no charge. Ions are atoms that have lost or gained electrons,\u00a0and as a result\u00a0have either a positive or negative charge. Atoms with the same number of protons \u2014 but different numbers of neutrons \u2014 are called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3675\"><strong>isotopes<\/strong><\/a>.<\/li>\n<li>There are almost 120 known elements. The majority of elements are\u00a0metals. A smaller number are\u00a0nonmetals. The latter include carbon, hydrogen, and oxygen.<\/li>\n<li>A compound is a substance that consists of two or more elements in a unique composition. The smallest particle of a compound is called a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3687\"><strong>molecule<\/strong><\/a>.\u00a0Chemical bonds\u00a0hold together the atoms of molecules. Compounds can form only in\u00a0chemical reactions, and they can break down only in other chemical reactions.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">3.2 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-10\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-10\" class=\"h5p-iframe\" data-content-id=\"10\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Definitions of Traditional Ecological Knowledge.\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What is an element? Give three examples.<\/li>\n<li>Define <em>compound<\/em>. Explain how compounds form.<\/li>\n<li>Compare and contrast atoms and molecules.<\/li>\n<li>The compound called water can be broken down into its constituent elements by applying an electric current to it. What ratio of elements is produced in this process?<\/li>\n<li>Relate ions and isotopes to elements and atoms.<\/li>\n<li>What is the most important element to life?<\/li>\n<li>Iron oxide is often known as rust \u2014 the reddish substance you might find on corroded metal. The chemical formula for this type of iron oxide is Fe<sub>2<\/sub>O<sub>3<\/sub>. Answer the following questions about iron oxide and briefly explain each answer.\n<ol type=\"a\">\n<li>Is iron oxide an element or a compound?<\/li>\n<li>Would one particle of iron oxide be considered a molecule or an atom?<\/li>\n<li>Describe the relative proportion of atoms in iron oxide.<\/li>\n<li>What causes the Fe and O to stick together in iron oxide?<\/li>\n<li>Is iron oxide made of metal atoms, metalloid atoms, nonmetal atoms, or a combination of any of these?<\/li>\n<\/ol>\n<\/li>\n<li>14C is an isotope\u00a0of carbon used in the radiocarbon dating of organic material. The most common isotope of carbon is\u00a012C. Do you think\u00a014C and\u00a012C have different numbers of neutrons or protons? Explain your answer.<\/li>\n<li>Explain why ions have a positive or negative charge.<\/li>\n<li>Name the three subatomic particles described in this section.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">3.2 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=yQP4UJhNn0I&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Just how small is an atom? TED-Ed, 2012<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 3.2.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/z7uU0C-4iUo\">Man Sitting<\/a>, by <a href=\"https:\/\/unsplash.com\/@junkanoo_media\">Gregory Culmer<\/a>, on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a>, is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash license<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 3.2.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Atom_Diagram.svg\">Lithium Atom diagram<\/a>, by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:AG_Caesar?uselang=bn\">AG Caesar<\/a>, is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY-SA 4.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en)<\/p>\n<p><strong>Figure 3.2.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Periodic_Table_Armtuk3.svg\">Periodic Table Armtuk3<\/a>, by <a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Armtuk&amp;action=edit&amp;redlink=1\">Armtuk<\/a>, is used under a <a href=\"http:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/<a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/\">)<\/a>\u00a0license.<\/p>\n<p><strong>Figure 3.2.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Water_molecule.svg\">Water molecule<\/a>, by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Sakurambo~commonswiki\">Sakurambo<\/a>, is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">TED-Ed. (2012, April 16). Just how small is an atom. YouTube. https:\/\/www.youtube.com\/watch?v=yQP4UJhNn0I&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3979\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3979\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_1587\" aria-describedby=\"caption-attachment-1587\" style=\"width: 373px\" class=\"wp-caption alignnone\"><img class=\"wp-image-1587\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Animal_Cell_Unannotated.svg_-1.png\" alt=\"\" width=\"373\" height=\"216\"><figcaption id=\"caption-attachment-1587\" class=\"wp-caption-text\"><em>Figure 4.4.1 Simple cut-away model of an animal cell.\u00a0<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_1588\" aria-describedby=\"caption-attachment-1588\" style=\"width: 368px\" class=\"wp-caption alignnone\"><img class=\"wp-image-1588\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/jello-mold-1.jpg\" alt=\"\" width=\"368\" height=\"245\"><figcaption id=\"caption-attachment-1588\" class=\"wp-caption-text\"><em>Figure 4.4.2 Jello molds containing fruit. <\/em><\/figcaption><\/figure>\n<div>\n<h1>A Bag Full of Jell-O<\/h1>\n<\/div>\n<p>The simple cut-away model of an animal <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3573\">cell<\/a> (Figure 4.4.1) shows that a cell resembles a plastic bag full of Jell-O. Its basic structure is a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3397\">plasma membrane<\/a> filled with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3373\">cytoplasm<\/a>. Like Jell-O containing mixed fruit (Figure 4.4.2), the cytoplasm of the cell also contains various structures, including a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3705\">nucleus<\/a> and other <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3465\">organelles<\/a>. Your body is composed of trillions of cells, but all of them perform the same basic life functions. They all obtain and use <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3661\">energy<\/a>, respond to the environment, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3715\">reproduce<\/a>. How do your cells carry out these basic functions and keep themselves \u2014 and you \u2014 alive? To answer these questions, you need to know more about the structures that make up cells, starting with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3397\">plasma membrane<\/a>.<\/p>\n<div>\n<h1><strong>What is<\/strong> the<strong> Plasma Membrane?<\/strong><\/h1>\n<\/div>\n<p>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3397\">plasma membrane<\/a> is a structure that forms a barrier between the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3373\">cytoplasm<\/a> inside the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3573\">cell<\/a> and\u00a0the environment\u00a0outside the cell. Without the plasma membrane, there would be no cell.\u00a0Although it is very thin and flexible, the plasma membrane protects and supports the cell by controlling everything that enters and leaves it.\u00a0It allows only certain substances to pass through, while keeping others in or out. To understand how the plasma membrane controls what passes into or out of the cell, you need to know its basic structure.<\/p>\n<div>\n<h2>Phospholipid Bilayer<\/h2>\n<\/div>\n<p>The plasma membrane is composed mainly of\u00a0phospholipids, which consist of fatty acids and alcohol. The phospholipids in the plasma membrane are arranged in two layers, called a\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3505\">phospholipid bilayer<\/a><\/strong>. As shown in the simplified diagram in Figure 4.4.3, each individual\u00a0 phospholipid molecule has a phosphate group head (in red) and two fatty acid tails (in yellow). The head \u201cloves\u201d water (<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3585\">hydrophilic<\/a>) and the tails \u201chate\u201d water (<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3583\">hydrophobic<\/a>). The water-hating tails are on the interior of the membrane, whereas the water-loving heads point outward, toward either the cytoplasm (intracellular) or the fluid that surrounds the cell (extracellular).<\/p>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3583\">Hydrophobic<\/a> molecules can easily pass through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3397\">plasma membrane<\/a> if they are small enough, because they are water-hating like the interior of the membrane. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3585\">Hydrophilic<\/a> molecules, on the other hand, <em>cannot<\/em> pass through the plasma membrane \u2014 at least not without help \u2014 because they are water-loving like the exterior of the membrane.<\/p>\n<figure id=\"attachment_1592\" aria-describedby=\"caption-attachment-1592\" style=\"width: 457px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-1592\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Phospholipid_Bilayer-3.jpg\" alt=\"Image shows a diagram of a phospholipid bilayer. The bilayer is made up of two sheets of phospholipids, with the fatty acid tails facing towards the center, and the phosphate heads on the two external surfaces.\" width=\"457\" height=\"308\"><figcaption id=\"caption-attachment-1592\" class=\"wp-caption-text\"><em>Figure 4.4.3 The phospholipid bilayer is made up of two sheets of phospholipids, with the fatty acid tails facing the centre.<\/em><\/figcaption><\/figure>\n<div>\n<h2>Other Molecules in the Plasma Membrane<\/h2>\n<\/div>\n<p>The plasma membrane also contains other molecules, primarily other <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3559\">lipids<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3721\">proteins<\/a>. The yellow molecules in the diagram here, for example, are the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3559\">lipid<\/a> cholesterol. Molecules of the steroid lipid cholesterol help the plasma membrane keep its shape. Proteins in the plasma membrane (shown blue in Figure 4.4.4) include: transport <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3721\">proteins<\/a> that assist other substances in crossing the cell membrane, receptors that allow the cell to respond to chemical signals in its environment, and cell-identity markers that indicate what type of cell it is and whether it belongs in the body.<\/p>\n<figure id=\"attachment_1595\" aria-describedby=\"caption-attachment-1595\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-1595\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lipid-bilayer-1.jpg\" alt=\"Image shows a diagram of a plasma membrane. The lipid bilayer contains embedded molecules including proteins, glycoproteins, glycolipids, and cholesterol.\" width=\"610\" height=\"279\"><figcaption id=\"caption-attachment-1595\" class=\"wp-caption-text\"><em>Figure 4.4.4 The plasma membrane contains many molecules embedded in the lipid bilayer.<\/em><\/figcaption><\/figure>\n<div>\n<h2>Additional Functions of the Plasma Membrane<\/h2>\n<\/div>\n<p>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3397\">plasma membrane<\/a> may have extensions, such as whip-like <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3515\">flagella<\/a> (singular flagellum) or brush-like <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_1597\">cilia<\/a> (singular cilium), shown below (Figure 4.4.5), that give it other functions. In single-celled organisms, these membrane extensions may help the organisms move. In multicellular organisms, the extensions have different functions. For example, the cilia on human lung cells sweep foreign particles and mucus toward the mouth and nose, while the flagellum on a human sperm cell allows it to swim.<\/p>\n<figure id=\"attachment_1598\" aria-describedby=\"caption-attachment-1598\" style=\"width: 379px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-1598\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Spermatozoa-human-3140x-1.jpg\" alt=\"Image shows a scanning electron microscope image of three human sperm on a porous surface.\" width=\"379\" height=\"265\"><figcaption id=\"caption-attachment-1598\" class=\"wp-caption-text\"><em>Figure 4.4.5 Human sperm with their long, whip-like flagella.<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_1599\" aria-describedby=\"caption-attachment-1599\" style=\"width: 369px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1599\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cilia-1.jpg\" alt=\"Image shows a scanning electron microscope image of the interior surface of bronchi. The cells lining the interior of this tube have clumps of cilia.\" width=\"369\" height=\"378\"><figcaption id=\"caption-attachment-1599\" class=\"wp-caption-text\"><em>Figure 4.4.6 Brush-like cilia on lung epithelial cells.<\/em><\/figcaption><\/figure>\n<div>\n<p><strong>Feature: My\u00a0<\/strong><strong>Human Body<\/strong><\/p>\n<\/div>\n<p>If you smoke or use e-cigarettes (vaping) and need another reason to quit, here's a good one.\u00a0We usually think of lung\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3513\">cancer<\/a>\u00a0as the major disease caused by smoking. But smoking and vaping can have devastating effects on the body's ability to protect itself from repeated, serious respiratory infections, such as bronchitis and pneumonia.<\/p>\n<figure id=\"attachment_5940\" aria-describedby=\"caption-attachment-5940\" style=\"width: 672px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-5940\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/1024px-Adverse_effects_of_vaping_raster-1.png\" alt=\"4.4.7 Adverse Affects of Vaping\" width=\"672\" height=\"910\"><figcaption id=\"caption-attachment-5940\" class=\"wp-caption-text\"><em>Figure 4.4.7 Airways of \u201chealthy\u201d vapors are abnormal - results of vaping.<\/em><\/figcaption><\/figure>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_1597\">Cilia<\/a> are microscopic, hair-like projects on\u00a0cells\u00a0that line the respiratory, reproductive, and digestive systems. Cilia in the\u00a0respiratory system\u00a0line most of your airways, where they have the job of trapping and removing dust, germs, and other foreign particles before they can make you sick. Cilia secrete mucus that traps particles, and they move in a continuous wave-like motion that sweeps the mucus and particles upward toward the throat, where they can be expelled from the body. When you are sick and cough up phlegm, that's what you are doing.<\/p>\n<p>Smoking prevents cilia from performing these important functions. Chemicals in tobacco smoke paralyze the cilia so they can't sweep mucus out of the airways. Those chemicals also inhibit the cilia from producing mucus. Fortunately, these effects start to wear off soon after the\u00a0most recent\u00a0exposure to tobacco smoke. If you stop smoking, your cilia will return to normal. Even if prolonged smoking has destroyed cilia, they will regrow and resume functioning in a matter of months after you stop smoking.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3397\">plasma membrane<\/a> is a structure that forms a barrier between the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3373\">cytoplasm<\/a> inside the cell and\u00a0the environment\u00a0outside the cell. It allows only certain substances to pass in or out of the cell.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3397\">plasma membrane<\/a> is composed mainly of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3505\">bilayer of phospholipid<\/a> molecules. It also contains other molecules, such as the steroid cholesterol, which helps the membrane keep its shape, and transport proteins, which help substances pass through the membrane.<\/li>\n<li>The\u00a0plasma\u00a0membranes of some cells have extensions that have other functions, like flagella to help\u00a0sperm\u00a0move, or cilia to help keep our airways clear.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What are the general functions of the plasma membrane?<\/li>\n<li>Describe the phospholipid bilayer of the plasma membrane.<\/li>\n<li>Identify other molecules in the plasma membrane. State their functions.<\/li>\n<li>Why do some cells have plasma membrane extensions, like flagella and cilia?<\/li>\n<li>Explain why hydrophilic molecules cannot easily pass through the cell membrane. What type of molecule in the cell membrane might help hydrophilic molecules pass through it?<\/li>\n<li>Which part of a phospholipid molecule in the plasma membrane is made of fatty\u00a0acid\u00a0chains? Is this part hydrophobic or hydrophilic?<\/li>\n<li>The two layers of\u00a0phospholipids\u00a0in the plasma membrane are called a phospholipid ____________.<\/li>\n<li>\n<div id=\"h5p-59\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-59\" class=\"h5p-iframe\" data-content-id=\"59\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Timeline of Pivotal Events in DNA Research\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Steroid hormones can pass directly through cell membranes. Why do you think this is the case?<\/li>\n<li>Some antibiotics work by making holes in the plasma membrane of bacterial cells. How do you think this kills the cells?<\/li>\n<li>What is the name of the long, whip-like extensions of the plasma membrane that helps some single-celled organisms move?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=yAXnYcUjn5k&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Insights into cell membranes via dish detergent - Ethan Perlstein, TED-Ed, 2013.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=qBCVVszQQNs<\/p>\n<p style=\"text-align: center\">Inside the cell membrane, by The Amoeba Sisters, 2018.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Animal_Cell_Unannotated.svg\">Animal Cell Unannotated,<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kelvin13\">Kelvin Song<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) public domain dedication license.<\/p>\n<p><strong>Figure 4.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/aimeeknight\/5184668689\/\">Jello mold at the mexican bakery<\/a> photo by <a href=\"https:\/\/www.flickr.com\/photos\/aimeeknight\/\">Aim\u00e9e Knight<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/p>\n<p><strong>Figure 4.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:0302_Phospholipid_Bilayer.jpg\" rel=\"cc:attributionURL\">Phospholipid_Bilayer<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/3-1-the-cell-membrane\">OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0) license.<\/p>\n<p><strong>Figure 4.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:0303_Lipid_Bilayer_With_Various_Components.jpg\" rel=\"cc:attributionURL\">Lipid bilayer<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/3-1-the-cell-membrane\">OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0) license.<\/p>\n<p><strong>Figure 4.4.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Spermatozoa-human-3140x.jpg\" rel=\"cc:attributionURL\">Spermatozoa-human-3140x<\/a> by No specific author on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:WP:PD\" href=\"https:\/\/en.wikipedia.org\/wiki\/WP:PD\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.4.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Bronchiolar_epithelium_3_-_SEM.jpg\">Cilia\/ Bronchiolar epithelium 3 - SEM<\/a> by Charles Daghlian on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:WP:PD\" href=\"https:\/\/en.wikipedia.org\/wiki\/WP:PD\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.4.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Adverse_effects_of_vaping_(raster).png\">Adverse effects of vaping (raster)<\/a> by <a title=\"User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:WP:PD\" href=\"https:\/\/en.wikipedia.org\/wiki\/WP:PD\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2018, February 27). Inside the cell membrane. YouTube. https:\/\/www.youtube.com\/watch?v=qBCVVszQQNs&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Betts, J.G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E.. Womble, M., DeSaix. P. (2013, April 25). Figure 3.3 Phospolipid Bilayer [digital image]. In <em>Anatomy and Physiology. OpenStax. <\/em>https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/3-1-the-cell-membrane<\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J.G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E.. Womble, M., DeSaix. P. (2013, April 25). Figure\u00a0<\/span><span class=\"os-number\">3.4<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"5458\" class=\"os-title\" data-type=\"title\">Cell Membrane<\/span><span class=\"os-divider\"> [digital image]. In <em>Anatomy and Physiology. OpenStax. <\/em>https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/3-1-the-cell-membrane<\/span><\/p>\n<p class=\"hanging-indent\">Ghosh, A., Coakley, R. C., Mascenik, T., Rowell, T. R., Davis, E. S., Rogers, K., Webster, M. J., Dang, H., Herring, L. E., Sassano, M. F., Livraghi-Butrico, A., Van Buren, S. K., Graves, L. M., Herman, M. A., Randell, S. H., Alexis, N. E., &amp; Tarran, R. (n.d.). Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome.\u00a0<i>American Journal of Respiratory and Critical \/Care Medicine<\/i>,\u00a0<i>198<\/i>(1), 67\u201376. https:\/\/doi-org.ezproxy.tru.ca\/10.1164\/rccm.201710-2033OC<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2013, February 26). Insights into cell membranes via dish detergent - Ethan Perlstein. YouTube. https:\/\/www.youtube.com\/watch?v=yAXnYcUjn5k&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_5491\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_5491\"><div tabindex=\"-1\"><p>each of the twelve bones of the backbone to which the ribs are attached.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3998\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3998\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<h1>Of Peas and People<\/h1>\n<figure id=\"attachment_7753\" aria-describedby=\"caption-attachment-7753\" style=\"width: 185px\" class=\"wp-caption alignleft\"><img class=\" wp-image-7753\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/sweet-pea-flower-1.jpg\" alt=\"5.10.1\" width=\"185\" height=\"278\"><figcaption id=\"caption-attachment-7753\" class=\"wp-caption-text\">Figure 5.10.1 Mendel conducted his research in genetics using pea plants.<\/figcaption><\/figure>\n<p>These purple-flowered plants are not just pretty to look at. Plants like these led to a huge leap forward in biology. They're\u00a0common garden peas, and they were studied in the mid-1800s by an Austrian monk named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Gregor_Mendel\">Gregor\u00a0Mendel<\/a>. Through careful experimentation, Mendel\u00a0uncovered the secrets of heredity, or how parents pass characteristics to their offspring.\u00a0You may not care much about heredity in pea plants, but you probably care about your\u00a0<em>own<\/em>\u00a0heredity. Mendel's discoveries apply to people, as well as to peas \u2014 and to all other living things that reproduce sexually. In this concept, you will read about Mendel's experiments and the secrets of heredity that he discovered.<\/p>\n<div>\n<h1><\/h1>\n<h1>Mendel\u00a0and His Pea Plants<\/h1>\n<\/div>\n<figure id=\"attachment_2437\" aria-describedby=\"caption-attachment-2437\" style=\"width: 204px\" class=\"wp-caption alignright\"><img class=\"wp-image-2437\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Gregor_Mendel-1.jpg\" alt=\"Image shows a photograph of Gregor Mendel\" width=\"204\" height=\"286\"><figcaption id=\"caption-attachment-2437\" class=\"wp-caption-text\"><em>Figure 5.10.2 Gregor Mendel. The Austrian monk Gregor Mendel experimented with pea plants. He did all of his research in the garden of the monastery where he lived.<\/em><\/figcaption><\/figure>\n<p>Gregor Mendel (Figure 5.10.2) was born in 1822. He grew up on his parents\u2019 farm in Austria. He did well in school and became a friar (and later an abbot) at St. Thomas' Abbey. Through sponsorship from the monastery, he went on to the University of Vienna, where he studied science and math. His professors encouraged him to learn science through experimentation, and to use math to make sense of his results. Mendel is best known for his experiments with pea plants (like the purple flower pictured in Figure 5.10.1).<\/p>\n<p>&nbsp;<\/p>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<h1>Blending Theory of Inheritance<\/h1>\n<figure id=\"attachment_2439\" aria-describedby=\"caption-attachment-2439\" style=\"width: 265px\" class=\"wp-caption alignleft\"><img class=\" wp-image-2439\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Gregor-Mendel-in-Lego-1.jpg\" alt=\"\" width=\"265\" height=\"199\"><figcaption id=\"caption-attachment-2439\" class=\"wp-caption-text\"><em>Figure 5.10.3 Gregor carried out much of his research at St. Thomas' Abbey.<\/em><\/figcaption><\/figure>\n<p>During Mendel's time, the blending theory of inheritance was popular.\u00a0According to this theory,\u00a0offspring have a blend (or mix) of their parents' characteristics. Mendel, however, noticed plants in his own garden that\u00a0<em>weren\u2019t<\/em>\u00a0a blend of the parents. For example, a tall plant and a short plant had offspring that were either tall or short \u2014 not medium in height. Observations such as these led Mendel to question the blending theory. He wondered if there was a different underlying principle that could explain how characteristics are inherited. He decided to\u00a0experiment\u00a0with pea plants to find out. In fact, Mendel experimented with almost <em>30 thousand pea plants<\/em> over the next several years!<\/p>\n<h1>Why Study Pea Plants?<\/h1>\n<p>Why did Mendel choose common, garden-variety pea plants for his experiments? Pea plants are a good choice because they are fast-growing and easy to raise. They also have several visible characteristics that can vary. These characteristics \u2014 some of which are illustrated in Figure 5.10.4 \u2014 include seed form and colour, flower colour, pod form and colour, placement of pods and flowers on stems, and stem length. Each of these characteristics has two common values. For example, seed form may be round or wrinkled, and flower colour may be white or purple (violet).<\/p>\n<figure id=\"attachment_2438\" aria-describedby=\"caption-attachment-2438\" style=\"width: 905px\" class=\"wp-caption alignnone\"><img class=\"wp-image-2438 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Mendels_peas-1.png\" alt=\"7 Characteristics of Peas\" width=\"905\" height=\"373\"><figcaption id=\"caption-attachment-2438\" class=\"wp-caption-text\"><em>Figure 5.10.4 Mendel investigated seven different characteristics in pea plants. In this chart, cotyledons refer to the tiny leaves inside seeds. Axial pods are located along the stems. Terminal pods are located at the ends of the stems.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Controlling Pollination<\/h1>\n<\/div>\n<p>To\u00a0research\u00a0how characteristics are passed from parents to offspring, Mendel needed to control\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2440\">pollination<\/a><\/strong>, which is the\u00a0fertilization\u00a0step in the\u00a0sexual reproduction\u00a0of plants. Pollen consists of tiny grains that are the male sex\u00a0cells (or gametes) of plants. They are produced by a male flower part called the anther. Pollination occurs when pollen is transferred from the anther to the stigma of the same or another flower. The stigma is a female part of a flower, and it passes pollen grains to female gametes in the ovary.<\/p>\n<p>Pea plants are naturally self-pollinating. In\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2441\">self-pollination<\/a><\/strong>, pollen grains from anthers on one plant are transferred to stigmas of flowers on the same plant. Mendel was interested in the offspring of two different parent plants, so he had to prevent self-pollination. He removed the anthers from the flowers of some of the plants in his experiments. Then he pollinated them by hand using a small paintbrush with pollen from other parent plants of his choice.<\/p>\n<p>When pollen from one plant fertilizes another plant of the same\u00a0species, it is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3871\">cross-pollination<\/a><\/strong>. The offspring that result from such a cross are called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2443\">hybrids<\/a><\/strong>. When the term\u00a0<em>hybrid<\/em>\u00a0is used in this context, it refers to any offspring resulting from the breeding of two genetically distinct individuals.<\/p>\n<div>\n<h1>Mendel's First Set of Experiments<\/h1>\n<\/div>\n<p>At first, Mendel experimented with just one characteristic at a time. He began with flower colour. As shown in Figure 5.10.5, Mendel cross-pollinated purple- and white-flowered parent plants. The parent plants in the experiments are referred to as the P (for parent) generation.<\/p>\n<figure id=\"attachment_2444\" aria-describedby=\"caption-attachment-2444\" style=\"width: 324px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2444\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/f-d_09511c7f2c66ed322470a626e776904a524be6566020efad10107bb7IMAGE_THUMB_POSTCARD_TINYIMAGE_THUMB_POSTCARD_TINY-1.png\" alt=\"Image illustrates the inheritance of colour in pea plants\" width=\"324\" height=\"410\"><figcaption id=\"caption-attachment-2444\" class=\"wp-caption-text\"><em>Figure 5.10.5 Mendel's first experiment with pea plants.\u00a0<\/em><\/figcaption><\/figure>\n<p>Figure 5.10.5 shows Mendel's first experiment with pea plants. The F1 generation results from the cross-pollination of two parent (P) plants, and it contains all purple flowers. The F2 generation results from the self-pollination of F1 plants, and contains 75% purple flowers and 25% white flowers.<\/p>\n<h2>F1 and F2 Generations<\/h2>\n<p>The offspring of the P generation are called the F1 (for filial, or \u201coffspring\u201d) generation. As shown in Figure 5.10.5, all of the plants in the F1 generation had purple flowers \u2014 none of them had white flowers. Mendel wondered what had happened to the white-flower characteristic. He assumed that some type of inherited factor produces white flowers and some other inherited factor produces purple flowers. Did the white-flower factor just disappear in the F1 generation? If so, then the offspring of the F1 generation \u2014 called the F2 generation \u2014 should <em>all<\/em>\u00a0have purple flowers like their parents.<\/p>\n<p>To test this prediction, Mendel allowed the F1 generation plants to self-pollinate. He was surprised by the results. Some of the F2 generation plants had white flowers. He studied hundreds of F2 generation plants, and for every three purple-flowered plants, there was an average of one white-flowered plant.<\/p>\n<h2>Law of Segregation<\/h2>\n<p>Mendel did the same experiment for all seven characteristics. In each case, one value of the characteristic disappeared in the F1 plants, later showing up again in the F2 plants. In each case, 75 per cent of F2 plants had one value of the characteristic, while 25 per cent had the other value. Based on these observations, Mendel formulated his first law of inheritance. This law is called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2445\">law of segregation<\/a><\/strong>. It states that there are two factors controlling a given characteristic, one of which dominates the other, and these factors separate and go to different gametes when a parent reproduces.<\/p>\n<div>\n<h1>Mendel's Second Set of Experiments<\/h1>\n<\/div>\n<p>Mendel wondered whether different characteristics are inherited together. For example, are purple flowers and tall stems always inherited together, or do these two characteristics show up in different combinations in offspring? To answer these questions, Mendel next investigated two characteristics at a time. For example, he crossed plants with yellow round seeds and plants with green wrinkled seeds. The results of this cross are shown in Figure 5.10.6.<\/p>\n<figure id=\"attachment_2446\" aria-describedby=\"caption-attachment-2446\" style=\"width: 366px\" class=\"wp-caption alignnone\"><img class=\"wp-image-2446 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/f-d_c9837ad4354fa77bf139410ea4dbae29dab1f9eb63381b2105707af7IMAGE_THUMB_POSTCARD_TINYIMAGE_THUMB_POSTCARD_TINY-1.png\" alt=\"This chart represents Mendel's second set of experiments. It shows the outcome of a cross between plants that differ in seed color (yellow or green) and seed form (shown here with a smooth round appearance or wrinkled appearance). The letters R, r, Y, and y represent genes for the characteristics Mendel was studying. Mendel didn\u2019t know about genes, however, because genes would not be discovered until several decades later. This experiment demonstrates that, in the F2 generation, nine out of 16 were round yellow seeds, three out of 16 were wrinkled yellow seeds, three out of 16 were round green seeds, and one out of 16 was wrinkled green seeds.\" width=\"366\" height=\"500\"><figcaption id=\"caption-attachment-2446\" class=\"wp-caption-text\">Figure 5.10.6 Mendel's second set of experiments.<\/figcaption><\/figure>\n<p><span style=\"text-align: initial;font-size: 1em\">Figure 5.10.6 shows the outcome of a cross between plants that differ in seed colour (yellow or green) and seed form (shown here with a smooth round appearance or wrinkled appearance). The letters R, r, Y, and y represent genes for the characteristics Mendel was studying. Mendel didn\u2019t know about genes, however, because genes would not be discovered until several decades later. This experiment demonstrates that, in the F2 generation, nine out of 16 were round yellow seeds, three out of 16 were wrinkled yellow seeds, three out of 16 were round green seeds, and one out of 16 was wrinkled green seeds.<\/span><\/p>\n<div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">F1 and F2 Generations<\/span><\/p>\n<\/div>\n<p>In this set of experiments, Mendel observed that plants in the F1 generation were all alike. All of them had yellow round seeds like one of the two parents. When the F1 generation plants self-pollinated, however, their offspring \u2014 the F2 generation \u2014 showed all possible combinations of the two characteristics. Some had green round seeds, for example, and some had yellow wrinkled seeds. These combinations of characteristics were not present in the F1 or P generations.<\/p>\n<h2>Law of Independent Assortment<\/h2>\n<p>Mendel repeated this experiment with other combinations of characteristics, such as flower colour and stem length. Each time, the results were the same as those shown in Figure 5.10.6. The results of Mendel's second set of experiments led to his second law. This is the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2447\">law of independent assortment<\/a><\/strong>. It states that factors controlling different characteristics are inherited independently of each other.<\/p>\n<div>\n<h1>Mendel's Legacy<\/h1>\n<\/div>\n<p>You might think that Mendel's discoveries would have made a big impact on science as soon as he made them, but you would be wrong. Why? Because Mendel's work was largely ignored. Mendel was far ahead of his time, and he was working from a remote monastery. He had no reputation\u00a0in\u00a0the\u00a0scientific community\u00a0and had only published sparingly in the past. Additionally, he published\u00a0this\u00a0research\u00a0in an\u00a0obscure\u00a0scientific journal. As a result, when\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Charles_Darwin\">Charles\u00a0Darwin<\/a>\u00a0published his landmark book on evolution in 1869, although Mendel's work had been published just a few years earlier, Darwin was unaware of it. Consequently, Darwin knew nothing about\u00a0Mendel's laws, and didn\u2019t understand heredity. This made Darwin's arguments about evolution less convincing to many.<\/p>\n<p>Then, in 1900, three different European scientists\u00a0\u2014\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Hugo_de_Vries\">Hugo de DeVries<\/a>, <a href=\"https:\/\/en.wikipedia.org\/wiki\/Carl_Correns\">Carl Correns<\/a>, and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Erich_von_Tschermak\">Erich von Tschermak<\/a>\u00a0\u2014\u00a0arrived independently at\u00a0Mendel's laws. All three had done experiments similar to Mendel's and come to the same conclusions that he had drawn several decades earlier. Only then was Mendel's work rediscovered, so that Mendel himself could be given the credit he was due. Although Mendel knew nothing about genes, which were discovered after his death, he is now considered the father of genetics.<\/p>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.10 Cultural Connection<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>Corn is the world's most produced crop.\u00a0 Canada produces 13,000-14,000 metric Kilo tonnes of corn annually, mostly in fields in Ontario, Quebec and Manitoba.\u00a0 Approximately 1.5 million hectares are devoted to this crop which is critically important for both humans and livestock as a food source.\u00a0 Despite these high numbers of output, Canada is still only 11th on the list of world corn producers, with USA, China and Brazil claiming the top three places.\u00a0 How did corn become such an important part of modern agriculture?<\/p>\n<figure id=\"attachment_2456\" aria-describedby=\"caption-attachment-2456\" style=\"width: 431px\" class=\"wp-caption alignright\"><img class=\" wp-image-2456\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Maize-teosinte-1.jpg\" alt=\"\" width=\"431\" height=\"267\"><figcaption id=\"caption-attachment-2456\" class=\"wp-caption-text\"><em>Figure 5.10.7 Teosinte (top) is the ancestor of modern corn. Hybrids (middle) were created using artificial selection, until modern corn (bottom) was developed.<\/em><\/figcaption><\/figure>\n<p>We didn't always have corn as we know it.\u00a0 Modern corn is descended from a type of grass called teosinte (Figure 5.10.7) native to Mesoamerica (southern part of North America).\u00a0 It is estimated that Indigenous people have been harvesting corn and corn ancestors for over 9000 years. Excavations of the Xihuatoxtla Shelter in southwestern Mexico revealed our earliest evidence of domesticated corn: maize remains on tools dating back 8,700 years.<\/p>\n<p>Ancient Indigenous peoples of southern Mexico developed corn from grass plants using a process we now call <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2453\">selective breeding<\/a>, also known as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3805\">artificial selection<\/a>.\u00a0 \u00a0Teosinte doesn't resemble the corn we have today- it had only a few kernels individually encased on very hard shells, and yet today we have multiple varieties of corn with row upon row of bare kernels.\u00a0 This means that ancient agriculturalists among the Indigenous people of Mexico were intentionally cross-breeding strains of teosinte, and later, early maize to create plants which had more kernels, and reduced seed casings.\u00a0 Watch the TED Ed video in the Explore More section to see what other changes agriculturalists have made to modern-day corn.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.10 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Mendel experimented with the inheritance of traits in pea plants at a time when the blending theory of inheritance was popular. This is the theory that offspring have a blend of the characteristics of their parents.<\/li>\n<li>Pea plants were good choices for this\u00a0research, largely because they have several visible characteristics that exist in two different forms. By controlling pollination, Mendel was able to cross pea plants with different forms of the traits.<\/li>\n<li>In Mendel's first set of experiments, he experimented with just one characteristic at a time. The results of this set of experiments led to Mendel's first law of inheritance, called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2445\">law of segregation<\/a>. This law states that there are two factors controlling a given characteristic, one of which dominates the other, and these factors separate and go to different gametes when a parent reproduces.<\/li>\n<li>In Mendel's second set of experiments, he experimented with two characteristics at a time. The results of this set of experiments led to Mendel's second law of inheritance, called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2447\">law of independent assortment<\/a>. This law states that the factors controlling different characteristics are inherited independently of each other.<\/li>\n<li>Mendel's work was largely ignored during his own lifetime. However, when other researchers arrived at the same laws in 1900, Mendel's work was rediscovered, and he was given the credit he was due. He is now considered the father of genetics.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.10 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>&nbsp;<\/p>\n<ol>\n<li>Why were pea plants a good choice for Mendel's experiments?<\/li>\n<li>\n<div id=\"h5p-69\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-69\" class=\"h5p-iframe\" data-content-id=\"69\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Regulation of Gene Expression\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>How did the outcome of Mendel's second set of experiments lead to his second law?<\/li>\n<li>Discuss the development of Mendel's legacy.<\/li>\n<li>If Mendel\u2019s law of independent assortment was\u00a0<em>not\u00a0<\/em>correct, and characteristics were\u00a0<em>always<\/em>\u00a0inherited together, what types of offspring do you think would have been produced by crossing plants with yellow round seeds and green wrinkled seeds? Explain your answer.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.10 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=Mehz7tCxjSE&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">How Mendel's pea plants helped us understand genetics - Hortensia Jim\u00e9nez D\u00edaz, TED-Ed, 2013.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=ogc367xyzfk&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">10 Strange Hybrid Fruits, Junkyboss, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=i6teBcfKpik<\/p>\n<p style=\"text-align: center\">The history of the world according to corn - Chris A. Kniesly, TED-Ed, 2019.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 5.10.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.publicdomainpictures.net\/en\/view-image.php?image=33799&amp;picture=sweet-pea-flower\">Purple sweet pea flower<\/a> by unknown on Yana Ray on <a href=\"http:\/\/publicdomainpictures.net\">publicdomainpictures.net<\/a> is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\"><span style=\"font-size: 1em\">CC0 1.0<\/span><\/a> <span style=\"font-size: 1em\">p<\/span>ublic domain dedication license <span style=\"font-size: 1em\">(<\/span><span style=\"font-size: 1em\">https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en)<\/span>.<\/p>\n<p><strong>Figure 5.10.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Gregor_Mendel.jpg\" rel=\"cc:attributionURL\">Gregor_Mendel<\/a> by unknown from <a id=\"anch_38\" href=\"https:\/\/www.nih.gov\/\">National Institutes of Health<\/a>,\u00a0<a id=\"anch_39\" href=\"https:\/\/www.hhs.gov\/\">Health &amp; Human Services<\/a> on Wikimedia Commons is in the <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 5.10.3<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/kaptainkobold\/356759039\" rel=\"cc:attributionURL\">Gregor Mendel in Lego<\/a>\u00a0by\u00a0<a href=\"https:\/\/www.flickr.com\/photos\/kaptainkobold\/\" rel=\"dc:creator\">Alan<\/a> on <a href=\"https:\/\/www.flickr.com\/\">Flickr<\/a> is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 5.10.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Mendels_peas.png\" rel=\"cc:attributionURL\">Mendels_peas<\/a> by Mariana Ruiz [<span class=\"licensetpl_attr\"><a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats<\/a><\/span>] on Wikimedia Commons is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\"><span style=\"font-size: 1em\">CC0 1.0<\/span><\/a> <span style=\"font-size: 1em\">p<\/span>ublic domain dedication license <span style=\"font-size: 1em\">(<\/span><span style=\"font-size: 1em\">https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en)<\/span>.<\/p>\n<p><strong>Figure 5.10.5<\/strong><\/p>\n<p><a href=\"https:\/\/dr282zn36sxxg.cloudfront.net\/datastreams\/f-d%3A09511c7f2c66ed322470a626e776904a524be6566020efad10107bb7%2BIMAGE_THUMB_POSTCARD_TINY%2BIMAGE_THUMB_POSTCARD_TINY.1\" rel=\"cc:attributionURL\">Mendel's first experiment with pea plants<\/a> by <a href=\"https:\/\/www.ck12.org\/book\/ck-12-human-biology\/section\/5.9\/\">CK-12 Foundation<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\">CC BY-NC 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.<\/p>\n<p><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em\">Licensed under\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/p>\n<p><strong>Figure 5.10.6<\/strong><\/p>\n<p><a href=\"https:\/\/dr282zn36sxxg.cloudfront.net\/datastreams\/f-d%3Ac9837ad4354fa77bf139410ea4dbae29dab1f9eb63381b2105707af7%2BIMAGE_THUMB_POSTCARD_TINY%2BIMAGE_THUMB_POSTCARD_TINY.1\" rel=\"cc:attributionURL\">Mendel's Second Experiment<\/a>\u00a0 by by <a href=\"https:\/\/www.ck12.org\/book\/ck-12-human-biology\/section\/5.9\/\">CK-12 Foundation<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\">CC BY-NC 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.<\/p>\n<p><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em\">Licensed under\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/p>\n<p><strong>Figure 5.10.7<\/strong><\/p>\n<\/div>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Maize-teosinte.jpg\" rel=\"cc:attributionURL\">Maize-teosinte<\/a> by John Doebley on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Brainard, J\/ CK-12 Foundation. (2016). Figure 5 Mendel's first experiment [digital image]. In <em>CK-12 College Human Biology\u00a0<\/em>(Section 5.9) [online Flexbook]. CK12.org. https:\/\/www.ck12.org\/book\/ck-12-human-biology\/section\/5.9\/<\/p>\n<p class=\"hanging-indent\">Brainard, J\/ CK-12 Foundation. (2016). Figure 6 Mendel's second experiment [digital image]. In <em>CK-12 College Human Biology\u00a0<\/em>(Section 5.9) [online Flexbook]. CK12.org. https:\/\/www.ck12.org\/book\/ck-12-human-biology\/section\/5.9\/<\/p>\n<p class=\"hanging-indent\">Junkyboss. (2016, March 31). 10 Strange hybrid fruits. YouTube. https:\/\/www.youtube.com\/watch?v=ogc367xyzfk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2013, March 12). How Mendel's pea plants helped us understand genetics - Hortensia Jim\u00e9nez D\u00edaz. YouTube. https:\/\/www.youtube.com\/watch?v=Mehz7tCxjSE&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2019, November 26). The history of the world according to corn - Chris A. Kniesly. YouTube. https:\/\/www.youtube.com\/watch?v=i6teBcfKpik&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 1). Carl Correns. In <em>Wikipedia<\/em>.\u00a0 https:\/\/en.wikipedia.org\/w\/index.php?title=Carl_Correns&amp;oldid=960172546<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, July 8). Charles Darwin. In\u00a0<i>Wikipedia. <\/i>https:\/\/en.wikipedia.org\/w\/index.php?title=Charles_Darwin&amp;oldid=966652322<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, March 9). Erich von Tschermak. In Wikipedia. https:\/\/en.wikipedia.org\/w\/index.php?title=Erich_von_Tschermak&amp;oldid=944695823<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, July 7). Hugo de Vries. In <em>Wikipedia<\/em>.\u00a0 https:\/\/en.wikipedia.org\/w\/index.php?title=Hugo_de_Vries&amp;oldid=966513671<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3999\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3999\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_2461\" aria-describedby=\"caption-attachment-2461\" style=\"width: 844px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2461\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/kelly-sikkema-FqqaJI9OxMI-unsplash-scaled-2.jpg\" alt=\"Image shows a dark, curly-haired man in his 20s or 30s holding and kissing a toddler with similar physical features and curly, dark hair, while the toddler smiles. \" width=\"844\" height=\"625\"><figcaption id=\"caption-attachment-2461\" class=\"wp-caption-text\"><em>Figure 5.11.1 Like Father, Like Son.<\/em><\/figcaption><\/figure>\n<h1>Like Father, Like Son<\/h1>\n<p>This father-son duo share some similarities.\u00a0 The shape of their faces and their facial features look very similar. If you saw them together, you might well guess that they are father and son. People have long known that the characteristics of living things are similar between parents and their offspring. However, it wasn\u2019t until the experiments of Gregor Mendel\u00a0that scientists understood\u00a0<em>how<\/em>\u00a0those traits are inherited.<\/p>\n<div>\n<h1>The Father of Genetics<\/h1>\n<\/div>\n<p>Mendel did experiments with pea plants to show how traits such as seed shape and flower colour are inherited. Based on his research, he developed his two well known laws of inheritance: the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2445\">law of segregation<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2447\">law of independent assortment<\/a>. When Mendel died in 1884, his work was still virtually unknown. In 1900, three other researchers working independently came to the same conclusions that Mendel had drawn almost half a century earlier. Only then was Mendel's work rediscovered.<\/p>\n<p>Mendel knew nothing about genes, because they\u00a0were discovered after his death. He did think, however, that some type of \"factors\" controlled traits, and that those \"factors\" were passed from parents to offspring. We now call these \"factors\" genes.\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2462\">Mendel's laws\u00a0of inheritance<\/a>, now expressed in terms of genes,\u00a0form the basis of\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3945\">genetics<\/a><\/strong>, the science of heredity. For this reason, Mendel is often called the father of genetics.<\/p>\n<div>\n<h1>The Language of Genetics<\/h1>\n<\/div>\n<p>Today, we know that traits of organisms are controlled by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3429\">genes<\/a> on\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3527\">chromosomes<\/a>. To talk about inheritance in terms of genes and chromosomes, you need to know the language of genetics.\u00a0The terms below serve\u00a0as\u00a0a good starting point. They are illustrated in the\u00a0figure\u00a0that follows.<\/p>\n<ul>\n<li>A\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3429\">gene<\/a><\/strong> is the part of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3527\">chromosome<\/a> that contains the\u00a0genetic code\u00a0for a given\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3721\">protein<\/a>. For example, in\u00a0pea plants, a given gene might code for flower\u00a0colour.<\/li>\n<li>The position of a given gene on a chromosome is called its\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2465\">locus<\/a> <\/strong>(plural, loci). A gene might be located near the center, or at one end or the other of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3527\">chromosome<\/a>.<\/li>\n<li>A given gene may have different normal versions, which are called <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3357\">alleles<\/a><\/strong><strong>.<\/strong> For example, in\u00a0pea plants, there is a purple-flower allele (B) and a white-flower allele (b) for the flower-colour\u00a0gene. Different\u00a0alleles account for much of the variation in the traits of organisms, including people.<\/li>\n<li>In sexually reproducing organisms, each individual has two copies of each type of chromosome. Paired\u00a0chromosomes\u00a0of the same type are called\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3517\"><strong>homologous<\/strong><strong>\u00a0<\/strong><strong>chromosomes<\/strong><\/a>. They are about the same size and shape, and they have all the same genes at the same loci.<\/li>\n<\/ul>\n<figure id=\"attachment_2466\" aria-describedby=\"caption-attachment-2466\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2466 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/f-d_56cb7ecdd193e58369e5f34a1b55594b30afa8c99312e8001ee5b70bIMAGE_THUMB_POSTCARD_TINYIMAGE_THUMB_POSTCARD_TINY-1.png\" alt=\"\" width=\"500\" height=\"203\"><figcaption id=\"caption-attachment-2466\" class=\"wp-caption-text\"><em>Figure 5.11.2 Chromosome, Gene, Locus, and Allele. This diagram shows how the concepts of chromosome, gene, locus, and allele are related. What is the difference between a gene and a locus? Between a gene and an allele?<\/em><\/figcaption><\/figure>\n<div>\n<h2>Genotype<\/h2>\n<\/div>\n<p>When\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2468\">sexual reproduction<\/a>\u00a0occurs, sex\u00a0cells\u00a0(called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3931\">gametes<\/a>) unite during\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3917\">fertilization<\/a>\u00a0to form a single cell called a\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2471\">zygote<\/a><\/strong>. The zygote inherits two of each type of chromosome, with one chromosome of each type coming from the father, and the other coming from the mother. Because <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3517\">homologous chromosomes<\/a> have the same genes at the same loci, each individual also inherits two copies of each gene. The two copies may be the same allele or different\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3357\">alleles<\/a>. The alleles an individual inherits for a given gene make up the individual\u2019s\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3947\">genotype<\/a><\/strong>. \u00a0As shown in Table 5.11.1, an organism with two of the same allele (for example, <em>BB<\/em>\u00a0or\u00a0<em>bb<\/em>) is called a\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2473\">homozygote<\/a><\/strong>. An organism with two different alleles (in this example,\u00a0<em>Bb<\/em>) is called a\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2474\">heterozygote<\/a><\/strong>.<\/p>\n<p><strong>Table 5.11.1\u00a0<\/strong><\/p>\n<p><em>Allele Combinations Associated With the Terms Homozygous and Heterozygous<\/em><\/p>\n<p><img class=\"wp-image-2476 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Untitled-1.png\" alt=\"Illustrates allele combinations associated with the terms homozygous and heterozygous\" width=\"746\" height=\"345\"><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Phenotype<\/span><\/p>\n<p>The expression of an organism\u2019s genotype is referred to as its\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2477\">phenotype<\/a><\/strong>, and it refers to the organism\u2019s traits, such as purple or white flowers in pea plants. As you can see from Table 5.11.1, different genotypes may produce the same phenotype. In this example, both <em>BB<\/em>\u00a0and\u00a0<em>Bb<\/em>\u00a0genotypes produce plants with the same phenotype, purple flowers. Why does this happen? In a\u00a0<em>Bb<\/em>\u00a0heterozygote, only the\u00a0<em>B<\/em>\u00a0allele is expressed, so the\u00a0<em>b <\/em>allele doesn\u2019t influence the phenotype. In general, when only one of two alleles is expressed in the phenotype, the expressed allele is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3879\">dominant<\/a>,<\/strong>\u00a0and the allele that isn\u2019t expressed is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2479\">recessive<\/a>.<\/strong><\/p>\n<p>The terms\u00a0<em>dominant<\/em>\u00a0and\u00a0<em>recessive<\/em> may also be used to refer to phenotypic traits. For example, purple flower colour in pea plants is a dominant trait. It shows up in the phenotype whenever a plant inherits even one dominant allele for the trait. Similarly, white flower colour is a recessive trait. Like other recessive traits, it shows up in the phenotype only when a plant inherits <em>two<\/em>\u00a0recessive alleles for the trait.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.11 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Mendel's laws\u00a0of inheritance, now expressed in terms of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3429\">genes<\/a>, form the basis of genetics, which is the science of heredity.\u00a0This is why Mendel is often called the father of genetics.<\/li>\n<li>A gene is the part of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3527\">chromosome<\/a> that codes for a given\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3721\">protein<\/a>. The position of a gene on a chromosome is its <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2465\">locus<\/a>.\u00a0\u00a0A given gene may have different versions, called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3357\">alleles<\/a>.\u00a0Paired chromosomes of the same type are called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3517\">homologous chromosomes<\/a>. They have the same size and shape, and they have the same genes at the same <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2465\">loci<\/a>.<\/li>\n<li>The alleles an individual inherits for a given gene make up the individual's <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3947\">genotype<\/a>. An organism with two of the same allele is called a homozygote, and an individual with two different alleles is called a heterozygote.<\/li>\n<li>The expression of an organism's genotype is referred to as its <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2477\">phenotype<\/a>. A dominant allele is always expressed in the phenotype, even when just one dominant allele has been inherited. A recessive allele is expressed in the phenotype only when two recessive alleles have been inherited.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.11 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Define genetics.<\/li>\n<li>Why is Gregor Mendel called the father of genetics if genes were not discovered until after his death?<\/li>\n<li>\n<div id=\"h5p-70\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-70\" class=\"h5p-iframe\" data-content-id=\"70\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Mendel&#039;s Experiments and Law of Inheritance\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Imagine that there are two alleles, <em>R <\/em>and\u00a0<em>r<\/em>, for a given gene.\u00a0<em>R<\/em>\u00a0is dominant to\u00a0<em>r<\/em>. Answer the following questions about this gene:\n<ol type=\"a\">\n<li>What are the possible homozygous and heterozygous genotypes?<\/li>\n<li>Which genotype or genotypes express the dominant\u00a0<em>R\u00a0<\/em>phenotype? Explain your answer.<\/li>\n<li>Are <em>R <\/em>and\u00a0<em>r<\/em>\u00a0on different loci? Why or why not?<\/li>\n<li>Can <em>R <\/em>and\u00a0<em>r<\/em>\u00a0be on the same exact chromosome? Why or why not? If not, where are they located?<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.11 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=pv3Kj0UjiLE<\/p>\n<p style=\"text-align: center\">Alleles and Genes, Amoeba Sisters, 2018.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=OaovnS7BAoc<\/p>\n<p style=\"text-align: center\">Genotypes and Phenotypes, Bozeman Science, 2011.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 5.11.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/FqqaJI9OxMI\">Father holding his baby boy with matching haircut<\/a> [photo] by <a href=\"https:\/\/unsplash.com\/@kellysikkema\">Kelly Sikkema<\/a> on <a href=\"http:\/\/Unsplash.com\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 5.11.2<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/5.10\/\">Chromosome, Gene, Locus, and Allele<\/a>\u00a0by <a href=\"https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/5.10\/\">CK-12 Foundation<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\">CC BY-NC 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.<\/p>\n<p><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em\">Licensed under\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/p>\n<p><strong>Table 5.11.1<\/strong><\/p>\n<p><em>Allele Combinations Associated With the Terms Homozygous and Heterozygous<\/em> by Christine Miller is released into the <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2018, February 1). Alleles and genes. YouTube. https:\/\/www.youtube.com\/watch?v=pv3Kj0UjiLE&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Bozeman Science. (2011, August 4). Genotypes and phenotypes. YouTube. https:\/\/www.youtube.com\/watch?v=OaovnS7BAoc&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Brainard, J\/ CK-12 Foundation. (2016). Figure 2 Chromosome, gene, locus, and allele [digital image]. In <em>CK-12 College Human Biology\u00a0<\/em>(Section 5.10) [online Flexbook]. CK12.org. https:\/\/www.ck12.org\/book\/ck-12-human-biology\/section\/5.9\/<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_6453\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_6453\"><div tabindex=\"-1\"><p>&nbsp;<\/p>\n<div>\n<figure id=\"attachment_3560\" aria-describedby=\"caption-attachment-3560\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-3560\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Goose_bumps-2.jpg\" alt=\"10.4.1\" width=\"400\" height=\"209\" \/><figcaption id=\"caption-attachment-3560\" class=\"wp-caption-text\"><em>Figure 10.4.1 Goose bumps!<\/em><\/figcaption><\/figure>\n<h1>Goose Bumps<\/h1>\n<\/div>\n<p>No doubt you\u2019ve experienced the tiny, hair-raising skin bumps called goose bumps, like those you see in Figure 10.4.1. They happen when you feel chilly. Do you know what causes goose bumps, or why they pop up when you are cold? The answers to these questions involve the layer of skin known as the dermis.<\/p>\n<div>\n<h1>What is the Dermis?<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5967\">dermis<\/a><\/strong>\u00a0is the inner of the two major layers that make up the skin, the outer layer being the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5991\">epidermis<\/a><\/strong>. The dermis consists mainly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2815\">connective tissues<\/a>. It also contains most skin structures, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2936\">glands<\/a>\u00a0and\u00a0blood vessels. The dermis is anchored to the tissues below it by flexible collagen bundles that permit most areas of the skin to move freely over subcutaneous (\u201cbelow the skin\u201d) tissues. Functions of the dermis include cushioning subcutaneous tissues, regulating body\u00a0temperature, sensing\u00a0the environment, and excreting wastes.<\/p>\n<div>\n<h1>Anatomy of the Dermis<\/h1>\n<\/div>\n<p>The basic anatomy of the dermis is a matrix, or sort of scaffolding, composed of connective tissues. These tissues include collagen fibres \u2014 which provide toughness \u2014 and elastin fibres, which provide elasticity. Surrounding these fibres, the matrix also includes a gel-like substance made of proteins. The tissues of the matrix give the dermis both strength and flexibility.<\/p>\n<p>The dermis is divided into two layers: the papillary layer and the reticular layer. Both layers are shown in Figure 10.4.2 below and described in the text that follows.<\/p>\n<figure id=\"attachment_3561\" aria-describedby=\"caption-attachment-3561\" style=\"width: 376px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-3561\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Layers_of_the_Dermis-2.jpg\" alt=\"Layers of the Dermis\" width=\"376\" height=\"485\" \/><figcaption id=\"caption-attachment-3561\" class=\"wp-caption-text\"><em>Figure 10.4.2 This photomicrograph shows a cross-section of the papillary and reticular layers of the dermis.<\/em><\/figcaption><\/figure>\n<h2>Papillary Layer<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5843\">papillary layer<\/a><\/strong> is the upper layer of the dermis, just below the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5907\">basement membrane<\/a> that connects the dermis to the epidermis above it. The papillary layer is the thinner of the two dermal layers. It is composed mainly of loosely arranged collagen fibres. The papillary layer is named for its fingerlike projections \u2014 or papillae \u2014 that extend upward into the epidermis. The papillae contain capillaries and sensory touch receptors.<\/p>\n<figure id=\"attachment_3563\" aria-describedby=\"caption-attachment-3563\" style=\"width: 390px\" class=\"wp-caption alignleft\"><img class=\" wp-image-3563\" src=\"http:\/\/humanbiology.pressbooks.tru.ca\/wp-content\/uploads\/sites\/6\/2019\/06\/Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d_T\u0159eb\u00ed\u010d_District.jpg#fixme\" alt=\"10.3 Fingerprints\" width=\"390\" height=\"260\" \/><figcaption id=\"caption-attachment-3563\" class=\"wp-caption-text\"><em>Figure 10.4.3 This photo is an enlarged image of epidermal ridges on a finger.<\/em><\/figcaption><\/figure>\n<p>The papillae give the dermis a bumpy surface that interlocks with the epidermis above it, strengthening the connection between the two layers of skin. On the palms and soles, the papillae create epidermal ridges. Epidermal ridges on the fingers are commonly called fingerprints (see Figure 10.4.3). Fingerprints are genetically determined, so no two people (other than identical twins) have exactly the same fingerprint pattern. Therefore, fingerprints can be used as a means of identification, for example, at crime scenes. Fingerprints were much more commonly used forensically before DNA analysis was introduced for this purpose.<\/p>\n<h2>Reticular Layer<\/h2>\n<p>The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5847\"><strong>reticular layer<\/strong> <\/a>is the lower layer of the dermis, located below the papillary layer. It is the thicker of the two dermal layers. It is composed of densely woven collagen and elastin fibres. These protein fibres give the dermis its properties of strength and elasticity. This layer of the dermis cushions subcutaneous tissues of the body from stress and strain. The reticular layer of the dermis also contains most of the structures in the dermis, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2936\">glands<\/a> and hair <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_6015\">follicle<span style=\"font-size: 1em;\">s<\/span><span style=\"text-align: initial; font-size: 1em;\"><\/a><\/span><span style=\"text-align: initial; font-size: 1em;\">.<\/span><\/p>\n<div>\n<h1>Structures in the Dermis<\/h1>\n<\/div>\n<p>Both papillary and reticular layers of the dermis contain numerous <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3006\">sensory receptors<\/a>, which make the skin the body\u2019s primary sensory organ for the sense of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3129\">touch<\/a>. Both dermal layers also contain blood vessels. They provide nutrients to remove wastes from dermal cells, as well as cells in the lowest layer of the epidermis, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3542\">stratum basale<\/a>. The circulatory components of the dermis are shown in Figure 10.4.4 below.<\/p>\n<figure id=\"attachment_3565\" aria-describedby=\"caption-attachment-3565\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-3565\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0802_Skin_DermalCirculation-2.png\" alt=\"10.3 Dermal Circulation\" width=\"1024\" height=\"819\" \/><figcaption id=\"caption-attachment-3565\" class=\"wp-caption-text\"><em>Figure 10.4.4 Both the papillary layer and the reticular layer of the dermis contain blood vessels, as shown in this diagram.<\/em><\/figcaption><\/figure>\n<h2>Glands<\/h2>\n<p>Glands in the reticular layer of the dermis include sweat glands and sebaceous (oil) glands. Both are exocrine glands, which are glands that release their secretions through ducts to nearby body surfaces. The diagram in Figure 10.4.5 shows these glands, as well as several other structures in the dermis.<\/p>\n<figure id=\"attachment_3567\" aria-describedby=\"caption-attachment-3567\" style=\"width: 702px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-3567 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anatomy_The_Skin_-_NCI_Visuals_Online-1-e1591224136617-2.jpg\" alt=\"10.4 Skin Glands\" width=\"702\" height=\"580\" \/><figcaption id=\"caption-attachment-3567\" class=\"wp-caption-text\"><em>Figure 10.4.5 The dermis contains sweat and oil (sebaceous) glands, as well as hair follicles and blood vessels.<\/em><\/figcaption><\/figure>\n<h3>Sweat Glands<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3566\">Sweat glands<\/a><\/strong>\u00a0produce the fluid called sweat, which contains mainly\u00a0water\u00a0and salts. The glands have ducts that carry the sweat to\u00a0hair\u00a0follicles, or to the surface of the skin. There are two different types of sweat glands: eccrine glands and apocrine glands.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3568\">Eccrine sweat gland<strong>s<\/strong><\/a><\/strong>\u00a0occur in skin all over the body. Their ducts empty through tiny openings called pores onto the skin surface. These sweat glands are involved in\u00a0temperature\u00a0regulation.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3569\">Apocrine sweat gland<strong>s<\/strong><\/a><\/strong>\u00a0are larger than eccrine glands, and occur only in the skin of the armpits and groin. The ducts of apocrine glands empty into hair follicles, and then the sweat travels along hairs to reach the surface. Apocrine glands are inactive until\u00a0puberty, at which point they start producing an oily sweat that is consumed by\u00a0bacteria\u00a0living on the skin. The digestion of apocrine sweat by bacteria\u00a0causes\u00a0body odor.<\/li>\n<\/ul>\n<h3>Sebaceous Glands<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3570\">Sebaceous gland<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0are exocrine glands that produce a thick, fatty substance called sebum.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3571\">Sebum<\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0is secreted into hair follicles and makes its way to the skin surface along hairs. It waterproofs the hair and skin, and helps prevent them from drying out. Sebum also has antibacterial properties, so it inhibits the growth of microorganisms on the skin. Sebaceous glands are found in every part of the skin \u2014 except for the palms of the hands and soles of the feet, where hair does not grow.<\/span><\/p>\n<h2>Hair Follicles<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3572\">Hair follicle<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0are the structures where hairs originate (see the diagram\u00a0above). Hairs grow out of follicles, pass through the epidermis, and exit at the surface of the skin. Associated with each hair follicle is a sebaceous gland, which secretes sebum that coats and waterproofs the hair. Each follicle also has a bed of capillaries, a nerve ending, and a tiny muscle called an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5839\">arrector pili<\/a>.<\/span><\/p>\n<div>\n<h1>Functions of the Dermis<\/h1>\n<\/div>\n<p>The main functions of the dermis are regulating body temperature, enabling the sense of touch, and eliminating wastes from the body.<\/p>\n<h2>Temperature Regulation<\/h2>\n<p>Several structures in the reticular layer of the dermis are involved in regulating body temperature. For example, when body temperature rises, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2937\">hypothalamus<\/a> of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5915\">brain<\/a> sends nerve signals to sweat glands, causing them to release sweat. An adult can sweat up to four litres an hour. As the sweat evaporates from the surface of the body, it uses energy in the form of body heat, thus cooling the body. The hypothalamus also causes dilation of blood vessels in the dermis when body temperature rises. This allows more blood to flow through the skin, bringing body heat to the surface, where it can radiate into the environment.<\/p>\n<p>When the body is too cool, sweat glands stop producing sweat, and blood vessels in the skin constrict, thus conserving body\u00a0heat. The arrector pili\u00a0muscles\u00a0also contract, moving hair follicles and lifting hair shafts. This results in more air being trapped under the hairs to insulate the surface of the skin. These contractions of arrector pili muscles are the cause of goose bumps.<\/p>\n<h2>Sensing\u00a0the Environment<\/h2>\n<p>Sensory receptors in the dermis are mainly responsible for the body\u2019s tactile\u00a0senses. The receptors detect such tactile stimuli as warm or cold temperature, shape, texture, pressure, vibration, and pain. They send\u00a0nerve impulses\u00a0to the brain, which interprets and responds to the sensory information. Sensory receptors in the dermis can be classified on the basis of the type of touch stimulus they sense.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3124\">Mechanoreceptor<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0sense mechanical forces such as pressure, roughness, vibration, and stretching.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3125\">Thermoreceptor<\/strong><strong style=\"font-size: 1em; text-align: initial;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0sense variations in temperature that are above or below body temperature.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3126\">Nociceptor<\/strong><strong style=\"font-size: 1em; text-align: initial;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\"> sense painful stimuli. Figure 10.4.6 shows several specific kinds of tactile receptors in the dermis. Each kind of receptor senses one or more types of touch stimuli.<\/span><\/p>\n<ul>\n<li>Free nerve endings sense pain and temperature variations.<\/li>\n<li>Merkel\u00a0cells\u00a0sense light touch, shapes, and textures.<\/li>\n<li>Meissner\u2019s corpuscles sense light touch.<\/li>\n<li>Pacinian corpuscles sense pressure and vibration.<\/li>\n<li>Ruffini corpuscles sense stretching and sustained pressure.<\/li>\n<\/ul>\n<figure id=\"attachment_3574\" aria-describedby=\"caption-attachment-3574\" style=\"width: 836px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-3574 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0809_Skin_TactileReceptors-e1591224860583-2.png\" alt=\"10.4 Tactile Receptors\" width=\"836\" height=\"669\" \/><figcaption id=\"caption-attachment-3574\" class=\"wp-caption-text\"><em>Figure 10.4.6 A variety of types of tactile receptors are located in the dermis of the skin.<\/em><\/figcaption><\/figure>\n<h2>Excreting Wastes<\/h2>\n<p>The sweat released by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3568\">eccrine sweat gland<span style=\"font-size: 1em;\">s<\/span><span style=\"text-align: initial; font-size: 1em;\"><\/a><\/span><span style=\"text-align: initial; font-size: 1em;\">\u00a0is one way the body excretes waste products. Sweat contains excess\u00a0water, salts (electrolytes), and other waste products that the body must get rid of to maintain\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5761\">homeostasis<\/a>. The most common electrolytes in sweat are sodium and chloride. Potassium, calcium, and magnesium electrolytes may be excreted in sweat, as well. When these electrolytes reach high levels in the\u00a0blood, more are excreted in sweat. This helps to bring their blood levels back into balance. Besides electrolytes, sweat contains small amounts of waste products from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5773\">metabolism<\/a>, including ammonia and urea. Sweat may also contain alcohol in someone who has been drinking alcoholic beverages.<\/span><\/p>\n<div>\n<h1>Feature: My\u00a0Human Body<\/h1>\n<\/div>\n<figure id=\"attachment_3575\" aria-describedby=\"caption-attachment-3575\" style=\"width: 343px\" class=\"wp-caption alignright\"><img class=\"wp-image-3575\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Akne-jugend-2.jpg\" alt=\"10.4.7\" width=\"343\" height=\"234\" \/><figcaption id=\"caption-attachment-3575\" class=\"wp-caption-text\"><em>Figure 10.4.7 Acne can be embarrassing, but most people will experience it at one point in their lives.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3576\">Acne<\/a><\/strong> is the most common skin disorder in the Canada. At least 20% of Canadians have acne at any given time and it affects approximately 90% of adolescents (as in Figure 10.4.7). Although acne occurs most commonly in teens and young adults, but it can occur at any age. Even newborn babies can get acne.<\/p>\n<p>The main sign of acne is the appearance of pimples (pustules) on the skin, like those in the photo above. Other signs of acne may include whiteheads, blackheads, nodules, and other lesions. Besides the face, acne can appear on the back, chest, neck, shoulders, upper arms, and buttocks. Acne can permanently scar the skin, especially if it isn\u2019t treated appropriately. Besides its physical effects on the skin, acne can also lead to low self-esteem and depression.<\/p>\n<p>Acne is caused by clogged, sebum-filled pores that provide a perfect environment for the growth of\u00a0bacteria. The bacteria cause infection, and the immune system responds with inflammation. Inflammation, in turn, causes swelling and redness, and may be associated with the formation of pus. If the inflammation goes deep into the skin, it may form an acne nodule.<\/p>\n<p>Mild acne often responds well to treatment with over-the-counter (OTC) products containing benzoyl peroxide or salicylic\u00a0acid. Treatment with these products may take a month or two to clear up the acne. Once the skin clears, treatment generally needs to continue for some time to prevent future breakouts.<\/p>\n<p>If acne fails to respond to OTC products, nodules develop, or acne is affecting self-esteem, a visit to a dermatologist is in order. A dermatologist can determine which treatment is best for a given patient. A dermatologist can also prescribe prescription medications (which are likely to be more effective than OTC products) and provide other medical treatments, such as laser light therapies or chemical peels.<\/p>\n<p>What can you do to maintain healthy skin and prevent or reduce acne? Dermatologists recommend the following tips:<\/p>\n<ul>\n<li>Wash affected or acne-prone skin (such as the face) twice a day, and after sweating.<\/li>\n<li>Use your fingertips to apply a gentle, non-abrasive cleanser. Avoid scrubbing, which can make acne worse.<\/li>\n<li>Use only alcohol-free products and avoid any products that irritate the skin, such as harsh astringents or exfoliants.<\/li>\n<li>Rinse with lukewarm\u00a0water, and avoid using very hot or cold water.<\/li>\n<li>Shampoo your hair regularly.<\/li>\n<li>Do not pick, pop, or squeeze acne. If you do, it will take longer to heal and is more likely to scar.<\/li>\n<li>Keep your hands off your face. Avoid touching your skin throughout the day.<\/li>\n<li>Stay out of the\u00a0sun\u00a0and tanning beds. Some acne medications make your skin very sensitive to UV light.<\/li>\n<\/ul>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5967\">dermis<\/a> is the inner and thicker of the two major layers that make up the skin. It consists mainly of a matrix of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2815\">connective tissue<\/a>s that provide strength and stretch. It also contains almost all skin structures, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3006\">sensory receptors<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5835\">blood vessel<\/a>s.<\/li>\n<li>The dermis has two layers. The upper <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5843\">papillary layer<\/a> has papillae extending upward into the epidermis and loose connective tissues. The lower <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_5847\">reticular layer<\/a> has denser connective tissues and structures, such as glands and hair follicles. Glands in the dermis include eccrine and apocrine sweat glands and sebaceous glands. Hair <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_6015\">follicles<\/a>\u00a0are structures where hairs originate.<\/li>\n<li>Functions of the dermis include cushioning subcutaneous tissues, regulating body temperature, sensing the environment, and excreting wastes. The dense connective tissues of the dermis provide cushioning. The dermis regulates body temperature mainly by sweating and by vasodilation or vasoconstriction. The many tactile sensory receptors in the dermis make it the main organ for the sense of touch. Wastes excreted in sweat include excess water, electrolytes, and certain metabolic wastes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is the dermis?<\/li>\n<li>Describe the basic anatomy of the dermis.<\/li>\n<li>Compare and contrast the papillary and reticular layers of the dermis.<\/li>\n<li>What causes epidermal ridges, and why can they be used to identify individuals?<\/li>\n<li>Name the two types of sweat glands in the dermis, and explain\u00a0how they differ.<\/li>\n<li>What is the function of sebaceous glands?<\/li>\n<li>Describe the structures associated with hair follicles.<\/li>\n<li>Explain how the dermis helps regulate body temperature.<\/li>\n<li>Identify three specific kinds of tactile receptors in the dermis, along with the type of stimuli they sense.<\/li>\n<li>How does the dermis excrete wastes? What waste products does it excrete?<\/li>\n<li>What are subcutaneous tissues?\u00a0Which layer of the dermis provides cushioning for subcutaneous tissues? Why does this layer provide most of the cushioning, instead of the other layer?<\/li>\n<li>For each of the functions listed below, describe which structure within the dermis carries it out.\n<ol type=\"a\">\n<li>Brings nutrients to and removes wastes from dermal and lower epidermal cells<\/li>\n<li>Causes hairs to move<\/li>\n<li>Detects painful stimuli on the skin<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE<\/p>\n<p style=\"text-align: center;\">How do you get rid of acne? SciShow, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center;\">When You Can't Scratch Away An Itch, Seeker, 2013.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 10.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Goose_bumps.jpg\" rel=\"cc:attributionURL\">Goose_bumps<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/photos\/61532128@N00\" rel=\"nofollow\">EverJean<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 10.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:506_Layers_of_the_Dermis.jpg\" rel=\"cc:attributionURL\">Layers_of_the_Dermis<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 10.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Fingerprint_detail_on_male_finger_in_T%C5%99eb%C3%AD%C4%8D,_T%C5%99eb%C3%AD%C4%8D_District.jpg\" rel=\"cc:attributionURL\">Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d,_T\u0159eb\u00ed\u010d_District<\/a> by <a title=\"User:Frettie\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Frettie\">Frettie<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong style=\"text-align: initial; font-size: 1em;\">Figure 10.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0802_Skin_DermalCirculation.png\" rel=\"cc:attributionURL\">Blausen_0802_Skin_Dermal Circulation<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial; font-size: 1em;\">\u00a0<a style=\"text-align: initial; font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anatomy_The_Skin_-_NCI_Visuals_Online.jpg\" rel=\"cc:attributionURL\">Anatomy_The_Skin_-_NCI_Visuals_Online<\/a>\u00a0by Don Bliss (artist) \/ \u00a0<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a class=\"extiw\" title=\"en:National Institutes of Health\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Institutes_of_Health\">National Institutes of Health<\/a>, with the ID\u00a0<a class=\"external text\" href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4604\" rel=\"nofollow\">4604<\/a>) is in the<span style=\"font-size: 1em;\"> <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/span><span style=\"text-align: initial; font-size: 1em;\">\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0809_Skin_TactileReceptors.png\" rel=\"cc:attributionURL\">Blausen_0809_Skin_TactileReceptors<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial; font-size: 1em;\">\u00a0<a style=\"text-align: initial; font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Akne-jugend.jpg\" rel=\"cc:attributionURL\">Akne-jugend<\/a> by <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> <span style=\"font-size: 1em;\">(https:\/\/en.wikipedia.org\/wiki\/public_domain)<\/span>. (No machine-readable author provided. <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a>\u00a0assumed, based on copyright claims).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure 5.7 Layers of the dermis [digital image]. In <em>Anatomy and Physiology<\/em> (Section 5.1 Layers of the skin). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin<\/p>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">SciShow. (2016, October 26). How do you get rid of acne? YouTube. https:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE<\/p>\n<p class=\"hanging-indent\">Seeker. (2013, October 26). When you can't scratch away an itch. YouTube. https:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;amp;feature=emb_logo<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_4001\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_4001\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_2514\" aria-describedby=\"caption-attachment-2514\" style=\"width: 691px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2514\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Albino_baby_by_Felipe_Fernandes_07-1.jpg\" alt=\"Image shows a young black woman holding and smiling at a delighted 9-month old albino baby.\" width=\"691\" height=\"461\"><figcaption id=\"caption-attachment-2514\" class=\"wp-caption-text\"><em>Figure 5.13.1 Like mother, like son.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Albinism<\/h1>\n<\/div>\n<p>This child has much lighter skin and\u00a0hair\u00a0than his parents. He has a condition called <a href=\"https:\/\/en.wikipedia.org\/wiki\/Albinism_in_humans\">albinism<\/a>, which results from a\u00a0lack of\u00a0the\u00a0pigment melanin in the\u00a0skin,\u00a0hair, and\u00a0eyes. Although\u00a0he\u00a0<em>looks<\/em>\u00a0different than his parents, albinism is actually a genetic trait.\u00a0<strong>Genetic traits<\/strong>\u00a0are characteristics that are encoded in\u00a0DNA. Most forms of albinism are recessive, which\u00a0is why\u00a0the child's\u00a0parents were able to\u00a0pass\u00a0the trait to him without exhibiting the condition themselves. You will learn more about this type of inheritance\u00a0in this concept.\u00a0Albinism is\u00a0one of the few human traits that actually has a simple inheritance pattern,\u00a0similar to\u00a0the traits that <a href=\"https:\/\/en.wikipedia.org\/wiki\/Gregor_Mendel\">Gregor\u00a0Mendel<\/a>\u00a0studied in\u00a0pea plants. The way these traits are inherited by offspring from their parents is called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2515\">Mendelian inheritance<\/a>.<\/p>\n<div>\n<h1>What Is Mendelian Inheritance?<\/h1>\n<\/div>\n<p><strong>Mendelian inheritance<\/strong>\u00a0refers to the inheritance of traits controlled by a single gene with two\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3357\">alleles<\/a>, one of which may be completely <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3879\">dominant<\/a> to the other. The pattern of inheritance of Mendelian traits depends on whether the traits are controlled by genes on <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2112\">autosome<\/a>s, or by genes on <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2125\">sex\u00a0chromosomes<\/a>.<\/p>\n<ul>\n<li><strong>Autosomal traits<\/strong>\u00a0are controlled by genes on one of the 22 pairs of human <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2112\">autosomes<\/a>. Autosomes are all the\u00a0chromosomes\u00a0except the X or Y chromosome, and they do not differ between males and females, so autosomal traits are inherited in the same way, regardless of the sex of the parent or offspring.<\/li>\n<li>Traits controlled by genes on the sex\u00a0chromosomes\u00a0are called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2516\">sex-linked traits<\/a>.<\/strong>\u00a0Because of the small size of the Y chromosome, most sex-linked traits are controlled by genes on the X chromosome. These traits are called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2517\">X-linked traits<\/a><\/strong>. Single-gene X-linked traits have a different pattern of inheritance than single-gene autosomal traits, because males have just one X chromosome. In addition, males always inherit their X chromosome from their mother, and they pass on their X chromosome to all of their daughters, but none of their sons.<\/li>\n<\/ul>\n<div>\n<h1>Studying Inheritance Patterns<\/h1>\n<\/div>\n<p>There are two very useful tools for studying how traits are passed from one generation to the next. One tool is a\u00a0pedigree, and the other is a Punnett square.<\/p>\n<h2>Pedigree<\/h2>\n<p>The chart below (Figure 5.13.2) is called a <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2519\">pedigree<\/a><\/strong>. A pedigree shows how a trait is passed from generation to generation within a family.\u00a0A pedigree can show, for example, whether a Mendelian trait is an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2112\">autosomal<\/a> or <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2517\">X-linked<\/a> trait. It can also be used to infer the genotype of different members of the family.<\/p>\n<p>The trait represented by\u00a0this\u00a0chart is a hypothetical autosomal trait controlled by a dominant allele. At the top of the pedigree, you can see symbols representing a married couple. The husband\u00a0<em>has<\/em> the trait (affected male), but the wife does not (unaffected female). The next row of the pedigree shows the couple's children, as well as the spouses of three of the children. For example, the first child on the left is an affected male married to an unaffected female. The third row of the pedigree shows the next generation (the grandchildren of the couple at the top of the pedigree). One child in this generation \u2014 the affected female on the left \u2014 is the sibling of an unaffected male.<\/p>\n<figure id=\"attachment_2518\" aria-describedby=\"caption-attachment-2518\" style=\"width: 666px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2518\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Pedigree_Chart2.svg_-1.png\" alt=\"Shows an example of a pedigree.\" width=\"666\" height=\"575\" data-wp-editing=\"1\"><figcaption id=\"caption-attachment-2518\" class=\"wp-caption-text\"><em>Figure 5.13.2 A pedigree chart is similar to a family tree. It shows how a trait is passed from parents to offspring in a family. The trait represented by this pedigree is an autosomal dominant trait.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Punnett Square<\/span><\/p>\n<\/div>\n<p>A\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2520\">Punnett square<\/a><\/strong> is a chart that allows you to easily determine the expected ratios of possible genotypes in the offspring of two parents. You can see a hypothetical example in Figure 5.13.3. In this case, the gene is autosomal, and both parents are heterozygotes <em>(Aa)<\/em>\u00a0for the gene. Half of the gametes produced by each parent will have the\u00a0<em>A<\/em>\u00a0allele, and half will have the\u00a0<em>a<\/em> allele. That's because the two\u00a0alleles\u00a0are on homologous chromosomes, which always separate and go to separate gametes during\u00a0meiosis. The alleles in the gametes from each parent are written down the side and across the top of the Punnett square. Filling in the\u00a0cells\u00a0of the Punnett square gives the possible genotypes of their children. It also shows the most likely ratios of the genotypes, which in this case is 25 per cent\u00a0<em>AA,<\/em> 50 per cent\u00a0<em>Aa,<\/em> and 25 per cent\u00a0<em>aa.<\/em><\/p>\n<figure id=\"attachment_2521\" aria-describedby=\"caption-attachment-2521\" style=\"width: 816px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2521\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Punnett-square-1.png\" alt=\"Image shows a sample of a Punnett Square\" width=\"816\" height=\"544\"><figcaption id=\"caption-attachment-2521\" class=\"wp-caption-text\"><em>Figure 5.13.3 A Punnett square shows the most likely proportions of offspring by genotype for a particular mating type.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"text-align: initial;font-size: 1em\">A Punnett square can also be used to show how the X and Y chromosomes are passed from parents to their children. This is illustrated in the Punnett square in Figure 5.13.4<\/span><span style=\"text-align: initial;font-size: 1em\">. It may help you understand the inheritance pattern of sex-linked traits.<\/span><\/p>\n<figure id=\"attachment_2522\" aria-describedby=\"caption-attachment-2522\" style=\"width: 295px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2522 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/f-d_0018fb7c7f3506876764d9d02d846116f8ed3a0040ed8a65cfc6be14IMAGE_THUMB_POSTCARD_TINYIMAGE_THUMB_POSTCARD_TINY-1.png\" alt=\"Image shows how Punnett Square can be used to predict inheritance of sex-linked traits\" width=\"295\" height=\"419\"><figcaption id=\"caption-attachment-2522\" class=\"wp-caption-text\"><em>Figure 5.13.4 Inheritance of Sex Chromosomes. Mothers pass only X chromosomes to their children. Fathers always pass their X chromosome to their daughters, and their Y chromosome to their sons. Can you explain why fathers always determine the sex of the offspring?<\/em><\/figcaption><\/figure>\n<\/div>\n<div>\n<p>Here's how to fill out a Punnett Square:<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=prkHKjfUmMs&amp;t=<\/p>\n<p style=\"text-align: center\">Learn Biology: How to Draw a Punnett Square, mahalodotcom, 2011.<\/p>\n<p>Try out this Punnett Square:<\/p>\n<div id=\"h5p-72\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-72\" class=\"h5p-iframe\" data-content-id=\"72\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Sexual Reproduction, Meiosis and Gametogenesis\"><\/iframe><\/div>\n<\/div>\n<h1>Autosomal Mendelian Traits in Humans<\/h1>\n<\/div>\n<p>Not many human autosomal traits are controlled by a single gene with two\u00a0alleles, but they are a good starting point for understanding human heredity. As discussed in the beginning of this concept, most forms of albinism in humans have\u00a0a Mendelian inheritance pattern.\u00a0Albinism\u00a0is usually controlled by a single autosomal gene with two alleles. The\u00a0allele\u00a0for normal pigmentation (let's call it\u00a0<em>R<\/em>) is dominant to the\u00a0allele\u00a0for albinism (<em>r<\/em>). Individuals with either an\u00a0<em>RR<\/em>\u00a0or\u00a0<em>Rr\u00a0<\/em>genotype will not have albinism, because the\u00a0<em>R<\/em>\u00a0allele\u00a0is dominant over the recessive\u00a0<em>r<\/em>\u00a0allele.<\/p>\n<p>However,\u00a0consider what happens if two individuals with the\u00a0<em>Rr<\/em>\u00a0genotype reproduce with each other. The outcome\u00a0would be\u00a0similar to\u00a0the example shown in the Punnett square\u00a0above\u00a0for two hypothetical\u00a0<em>Aa<\/em>\u00a0individuals.\u00a0Their possible\u00a0offspring\u00a0could be\u00a0<em>RR<\/em>\u00a0(normal pigmentation),\u00a0<em>Rr<\/em>\u00a0(normal pigmentation), or\u00a0<em>rr<\/em>\u00a0(albinism). This explains why a child with albinism (<em>rr<\/em>), can have two parents that do not have albinism. Both unaffected parents must be a carrier of the recessive\u00a0<em>r<\/em>\u00a0allele, but they also have a dominant\u00a0<em>R <\/em>allele that prevents them from having the condition themselves.<\/p>\n<p>Some other human traits that\u00a0have a\u00a0Mendelian inheritance pattern\u00a0are Huntington's disease and\u00a0wet\u00a0versus\u00a0dry ear wax. You may have heard about other human traits that were\u00a0<em>previously<\/em>\u00a0thought to be Mendelian,\u00a0such as dimples, a widow's peak hairline, hitchiker's thumb, and the ability to roll your tongue. As science has progressed, it is now understood that these are not actually Mendelian traits. In fact, most human traits are actually controlled by multiple genes, or otherwise have more than two alleles,\u00a0which means they\u00a0do not have\u00a0a\u00a0simple Mendelian inheritance pattern.<\/p>\n<div>\n<h1>X-Linked Mendelian Traits in Humans<\/h1>\n<\/div>\n<figure id=\"attachment_2525\" aria-describedby=\"caption-attachment-2525\" style=\"width: 366px\" class=\"wp-caption alignright\"><img class=\"wp-image-2525\" style=\"font-size: 1em\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Red-Green-Colour-Blindness-1.png\" alt=\"Shows a Ishihara plate for detecting red-green colour blindness.\" width=\"366\" height=\"366\"><figcaption id=\"caption-attachment-2525\" class=\"wp-caption-text\"><em>Figure 5.13.5 This circle of colours containing the number 74 is part of the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Ishihara_test\">Ishihara colour blindness test.<\/a><\/em><\/figcaption><\/figure>\n<p>Because males have just one X chromosome, they have only one allele for any X-linked trait. Therefore, a recessive X-linked allele is always expressed in males. Because females have two X chromosomes, they have two alleles for any X-linked trait. Therefore, they must inherit two copies of the recessive allele to express an X-linked recessive trait. This explains why X-linked recessive traits are less common in females than males, and why they show a different pattern of inheritance than autosomal traits.<\/p>\n<figure id=\"attachment_2527\" aria-describedby=\"caption-attachment-2527\" style=\"width: 334px\" class=\"wp-caption alignleft\"><img class=\"wp-image-2527\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/XlinkRecessive-1-1.jpg\" alt=\"Image shows the heredity implications of an X-linked recessive gene carried by the mother.\" width=\"334\" height=\"431\"><figcaption id=\"caption-attachment-2527\" class=\"wp-caption-text\"><em>Figure 5.13.6 Heredity implications of an X-linked recessive gene carried by the mother. <\/em><\/figcaption><\/figure>\n<p>An example of a recessive X-linked trait is red-green colour blindness. People with this trait cannot distinguish between the colours red and green. More than one recessive gene on the X chromosome codes for this trait, which is fairly common in males, but relatively rare in females. Figure 5.13.6 shows a simple pedigree for this trait. A female with one of the recessive alleles for the trait does not have the trait herself, but can pass it on to her children. In this case, she is called a carrier of the trait. Half of any sons she has can be expected to have the trait, because there is a 50 per cent chance that they will inherit the X chromosome with the colour-blindness allele. Having only one X chromosome, the recessive allele will be expressed in the sons who inherit it. However, as long as the father is not affected, none of the woman's daughters will have the trait. The daughters have a 50 per cent chance of inheriting the X chromosome with the colour-blindness allele, but it won't be expressed because it is recessive to the normal allele they inherit from their father.<\/p>\n<figure id=\"attachment_2529\" aria-describedby=\"caption-attachment-2529\" style=\"width: 282px\" class=\"wp-caption alignright\"><img class=\"wp-image-2529\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/The_Young_Queen_Victoria-1.jpg\" alt=\"\" width=\"282\" height=\"382\"><figcaption id=\"caption-attachment-2529\" class=\"wp-caption-text\"><em>Figure 5.13.7 Queen Victoria carried hemophilia and she passed the hemophilia allele to two of her daughters and one of her sons. This portrait of her was painted in the 1840s.<\/em><\/figcaption><\/figure>\n<p>Another example of a recessive X-linked Mendelian trait is hemophilia, which is a disorder characterized by the blood's inability to clot normally. England's Queen Victoria (pictured in Figure 5.13.7) carried the disorder. Two of her five daughters inherited the hemophilia allele from their mother and were carriers. When they married royalty in other European countries, they spread the allele across Europe, including to the royal families of Spain, Germany, and Russia. Victoria's son Prince Leopold also inherited the hemophilia allele from his mother, and he actually suffered from the disease. Understandably, hemophilia was once popularly called \"the royal disease.\"<\/p>\n<div>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 22.784px\">Feature: My\u00a0Human Body<\/span>.<\/p>\n<\/div>\n<p>Are you colour blind, or do you think you might be? If you inherited this X-linked recessive disorder, a world without clear differences between certain colours seems normal to you. It's all you have ever known! Some people who are colour blind are not even aware of it. Simple tests have been devised to determine whether a person is colour blind, and to what degree. An example of such a test is pictured in Figure 5.13.5. What do you see when you look at this circle? Can you clearly perceive the number 74? If so, you probably have normal red-green colour vision. If you cannot see the number, you may have red-green colour blindness.<\/p>\n<figure id=\"attachment_2530\" aria-describedby=\"caption-attachment-2530\" style=\"width: 484px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2530 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Deuteranopia-1.jpg\" alt=\"Image shows the difference in perception of colours between a person with normal vision and someone with red-green colour blindness.\" width=\"484\" height=\"278\"><figcaption id=\"caption-attachment-2530\" class=\"wp-caption-text\"><em>Figure 5.13.8 Perception of colours comparison.<\/em><\/figcaption><\/figure>\n<p>Being colour blind can cause a number of problems. These may range from minor frustrations to outright dangers. Here are a few examples:<\/p>\n<ul>\n<li>If you are colour blind, it may be difficult to colour-coordinate clothing and furnishings. You may end up wearing colour combinations that people with normal colour vision think are odd or clashing.<\/li>\n<li>Many LED indicator lights are red or green.\u00a0Power strips and electronic devices, for example, may have indicator lights to show whether they are on (green) or off (red).<\/li>\n<li>Test strips for pH, hard water, swimming pool chemicals, and other common tests are also often colour coded. Litmus paper for testing pH, for example, turns red in the presence of an acid, but if you are colour blind, you may not be able to read the test result.<\/li>\n<li>Do you like your steak well done? If you are colour blind, you may not be able to tell if the meat is still undercooked (red) or grilled just right. You also may not be able to distinguish ripe (red) from unripe (green) fruits and vegetables, such as tomatoes. And some foods, such as dark green spinach, may look more like mud than food, making them totally unappetizing.<\/li>\n<li>Weather maps often are colour coded. Is that rain (green) in your forecast, or a wintry mix of sleet and freezing rain (pink or red)? If you can't tell the difference, you may go out on the roads when you shouldn't, putting yourself in danger.<\/li>\n<li>Being able to distinguish red from green traffic lights may be a matter of life or death. This can be very difficult for someone with red-green colour blindness. In some countries, people with this vision defect are not allowed to drive.<\/li>\n<\/ul>\n<div id=\"h5p-73\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-73\" class=\"h5p-iframe\" data-content-id=\"73\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Punnett Square Practice\"><\/iframe><\/div>\n<\/div>\n<p><em>Figure 5.13.9\u00a0 Examples of challenges faced by those who are colour blind<\/em><\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.13 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2515\">Mendelian inheritance<\/a> refers to the inheritance of traits controlled by a single <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3429\">gene<\/a> with two <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3357\">alleles<\/a>, one of which may be completely dominant to the other. The pattern of inheritance of Mendelian traits depends on whether the traits are controlled by genes on <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2112\">autosomes<\/a>, or by genes on <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2125\">sex chromosomes<\/a>.<\/li>\n<li>Two tools for studying inheritance are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2519\">pedigrees<\/a> and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2520\">Punnett squares<\/a>. A pedigree is a chart that shows how a trait is passed from generation to generation within a family. A Punnett square is a chart that shows the expected ratios of possible <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3947\">genotypes<\/a> in the offspring of two parents.<\/li>\n<li>Examples of human autosomal Mendelian traits include albinism and Huntington's disease. Examples of human X-linked traits include red-green colour blindness and hemophilia.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.13 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Define genetic traits and Mendelian inheritance.<\/li>\n<li>\n<div id=\"h5p-74\">\n<div class=\"h5p-content\" data-content-id=\"74\"><\/div>\n<\/div>\n<\/li>\n<li>Explain why autosomal and X-linked Mendelian traits have different patterns of inheritance.<\/li>\n<li>Identify examples of human autosomal and X-linked Mendelian traits.<\/li>\n<li>Imagine a hypothetical human gene that has two alleles,<em>Q<\/em>and\u00a0<em>q<\/em>.\u00a0<em>Q<\/em>\u00a0is dominant to\u00a0<em>q<\/em>\u00a0and the inheritance of this gene is Mendelian. Answer the following questions about this gene.\n<ol type=\"a\">\n<li>If a woman has the genotype\u00a0<em>Q q\u00a0<\/em>and her husband has the genotype\u00a0<em>QQ<\/em>, list each of their possible gametes. What proportion of their gametes will have each allele?<\/li>\n<li>What are the likely proportions of their offspring being<em>QQ<\/em>,<em>Qq<\/em>, or\u00a0<em>qq<\/em>?<\/li>\n<li>Is this an autosomal trait or an X-linked trait? How do you know?<\/li>\n<li>What are the chances of their offspring exhibiting the dominant\u00a0<em>Q\u00a0<\/em>trait? Explain your answer.<\/li>\n<\/ol>\n<\/li>\n<li>Explain why fathers always pass their X chromosome down to their daughters.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.13 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=h2xufrHWG3E&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Punnett Squares and Sex-Linked Traits, Amoeba Sisters, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=Gd09V2AkZv4<\/p>\n<p style=\"text-align: center\">Pedigrees, Amoeba Sisters, 2017.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=veB31XmUQm8<\/p>\n<p style=\"text-align: center\">Secrets of the X chromosome - Robin Ball, TED-Ed, 2017.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 5.13.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Albino_baby_by_Felipe_Fernandes_07.jpg\" rel=\"cc:attributionURL\">Albino_baby_by_Felipe_Fernandes<\/a>\u00a0by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/photos\/felipefdesign\/\" rel=\"nofollow\">Felipe Fernandes<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/deed.en\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0) license.<\/p>\n<p><strong>Figure 5.13.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Autosomal_Dominant_Pedigree_Chart2.svg\" rel=\"cc:attributionURL\">Pedigree_Chart2.svg<\/a> by Jerome Walker on Wikimedia Commons is used under a <a href=\"http:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/\">CC BY-SA 3.0<\/a> (http:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/) license. (Derivative work of original <a title=\"File:Autosomal Dominant Pedigree Chart.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Autosomal_Dominant_Pedigree_Chart.svg\">image<\/a>\u00a0created by\u00a0<a class=\"new\" title=\"User:GAThrawn22 (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:GAThrawn22&amp;action=edit&amp;redlink=1\">GAThrawn22<\/a>)<\/p>\n<p><strong>Figure 5.13.3<\/strong><\/p>\n<p>Punnett square by Christine Miller is released into the <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 5.13.4<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/5.12\/\" rel=\"cc:attributionURL\">Inheritance of Sex Chromosomes<\/a> by <a href=\"https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/5.12\/\">CK-12 Foundation<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\">CC BY-NC 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.<\/p>\n<p><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em\">Licensed under\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/p>\n<p><strong>Figure 5.13.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Ishihara_9.png\" rel=\"cc:attributionURL\">Red-Green Colour Blindness<\/a> by Unknown author on Wikimedia is released into the <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\u00a0(Original believed to be by <a href=\"https:\/\/en.wikipedia.org\/wiki\/Shinobu_Ishihara\">Shinobu Ishihara<\/a>)<\/p>\n<p><strong>Figure 5.13.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:XlinkRecessive.jpg\" rel=\"cc:attributionURL\">XlinkRecessive<\/a> by US\u00a0<a class=\"extiw\" title=\"w:National Institutes of Health\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Institutes_of_Health\">National Institutes of Health<\/a> on Wikimedia Commons is in the <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 5.13.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:The_Young_Queen_Victoria.jpg\" rel=\"cc:attributionURL\">The_Young_Queen_Victoria (painted portrait<\/a> by <a href=\"https:\/\/en.wikipedia.org\/wiki\/Franz_Xaver_Winterhalter\">Franz Xaver Winterhalter<\/a> (photograph from the Osborne House, Isle of Wight) on Wikimedia Commoons is in the <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong style=\"text-align: initial;font-size: 1em\">Figure 5.13.8<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/webstyleguide\/25379791138\" rel=\"cc:attributionURL\">Deuteranopia\/ Figure 9.10<\/a>\u00a0by <a class=\"owner-name truncate\" title=\"Go to Web Style Guide's photostream\" href=\"https:\/\/www.flickr.com\/photos\/webstyleguide\/\" data-track=\"attributionNameClick\">Web Style Guide<\/a> on <a href=\"https:\/\/www.flickr.com\/\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 5.13.9<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=File:LED_traffic_light.jpg&amp;oldid=248599431\">LED traffic light<\/a> by <a title=\"User:Bidgee\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Bidgee\">Bidgee<\/a> on <i>Wikimedia <\/i>is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=File:Universal_indicator_paper.jpg&amp;oldid=425236425\">Universal indicator paper<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Bordercolliez&amp;action=edit&amp;redlink=1\">Bordercolliez<\/a> on <em>Wikimedia <\/em>is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a><br \/>\nPublic Domain Dedication license (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en)<\/li>\n<li><a href=\"https:\/\/pixabay.com\/photos\/fruit-tomatoes-food-1010514\/\">Photo tags: Fruit tomatoes food fruits and vegetables fresh<\/a> by <a href=\"https:\/\/pixabay.com\/users\/inspiredimages-57296\/\">InspiredImages<\/a> on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a>\u00a0(https:\/\/pixabay.com\/service\/license\/).<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=File:SIMPLE_CONTROL_WITH_INDICATOR_LIGHTS.jpg&amp;oldid=298043241\">Simple Control with Indicator LIghts<\/a> by <a class=\"new\" title=\"User:Sam D. Wilbur (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Sam_D._Wilbur&amp;action=edit&amp;redlink=1\">Sam D. Wilbur<\/a> on Wikimedia is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/pixabay.com\/photos\/feet-socks-checkered-striped-pants-11561\/\">Photo tags: Feet socks checkered striped pants colorful color<\/a> by <a href=\"https:\/\/pixabay.com\/users\/suppenkasper-1357\/\">Suppenkasper<\/a> on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a>\u00a0(https:\/\/pixabay.com\/service\/license\/).<\/li>\n<\/ul>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2015, January 23).\u00a0 Punnett squares and sex-linked traits. YouTube. https:\/\/www.youtube.com\/watch?v=h2xufrHWG3E&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Amoeba Sisters. (2017, February 8). Pedigrees. YouTube. https:\/\/www.youtube.com\/watch?v=Gd09V2AkZv4&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Brainard, J\/ CK-12 Foundation. (2016). Figure 3 Inherited traits of sex chromosomes [digital image]. In <em>CK-12 College Human Biology\u00a0<\/em>(Section 5.12) [online Flexbook]. CK12.org. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/5.12\/<\/p>\n<p class=\"hanging-indent\">mahalodotcom. (2011, January 14). Learn biology: How to draw a punnett square. YouTube. https:\/\/www.youtube.com\/watch?v=prkHKjfUmMs&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2017, <span style=\"text-align: initial;font-size: 1em\">April 18). Secrets of the X chromosome - Robin Ball. YouTube. https:\/\/www.youtube.com\/watch?v=veB31XmUQm8&amp;feature=youtu.be<\/span><\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 26). Albinism in humans. In <em>Wikipedia<\/em>. https:\/\/en.wikipedia.org\/w\/index.php?title=Albinism_in_humans&amp;oldid=964622728<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 29). Gregor Mendel. In <em>Wikipedia<\/em>. https:\/\/en.wikipedia.org\/w\/index.php?title=Gregor_Mendel&amp;oldid=965090119<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 17). Ishihara test. In\u00a0<i>Wikipedia. <\/i>https:\/\/en.wikipedia.org\/w\/index.php?title=Ishihara_test&amp;oldid=963014774<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_4002\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_4002\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<p>&nbsp;<\/p>\n<div id=\"h5p-75\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-75\" class=\"h5p-iframe\" data-content-id=\"75\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Mendelian Inheritance\"><\/iframe><\/div>\n<\/div>\n<p><em>Figure 5.14.1 Collage of Diverse Faces.<\/em><\/p>\n<p>This collage shows some of the variation in human skin colour, which can range from very light to very dark, with every possible gradation in between.\u00a0 As you might expect, the skin color trait has a more complex genetic basis than just one gene with two alleles, which is the type of simple trait that Mendel studied in pea plants. Like skin color, many other human traits have more complicated modes of inheritance than Mendelian traits. Such modes of inheritance are called <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2537\">non-Mendelian inheritance<\/a>,<\/strong>\u00a0and they include inheritance of\u00a0multiple allele traits, traits with codominance or incomplete dominance, and\u00a0polygenic traits, among others. All of\u00a0these modes\u00a0are described below.<\/p>\n<div>\n<h1>Multiple Allele Traits<\/h1>\n<\/div>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_2709\" aria-describedby=\"caption-attachment-2709\" style=\"width: 385px\" class=\"wp-caption alignright\"><img class=\" wp-image-2709\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Blood-types-1-1.png\" alt=\"ABO Blood types\" width=\"385\" height=\"408\"><figcaption id=\"caption-attachment-2709\" class=\"wp-caption-text\"><em>Figure 5.14.2 ABO blood types per genotype.<\/em><\/figcaption><\/figure>\n<p>The majority of human genes are thought to have more than two normal versions, or\u00a0alleles. Traits controlled by a single gene with more than two alleles are called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2540\">multiple allele traits<\/a><\/strong>. An example is ABO blood type. Your blood type refers to which of certain proteins called antigens are found on your red blood cells. There are three common alleles for this trait, which are represented by the letters A, B, and O.<\/p>\n<p>As shown in the table there are six possible ABO genotypes, because the three alleles, taken two at a time, result in six possible combinations. The A and B alleles are dominant to the O allele. As a result, both AA and AO genotypes have the same phenotype, with the A antigen in their blood (type A blood). Similarly, both BB and BO genotypes have the same phenotype, with the B antigen in their blood (type B blood). No antigen is associated with the O allele, so people with the OO genotype have no antigens for ABO blood type in their blood (type O blood).<\/p>\n<div>\n<h1>Codominance<\/h1>\n<\/div>\n<p>Look at the genotype AB in the ABO blood group table. Alleles A and B for ABO blood type\u00a0are neither <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3881\">dominant<\/a> nor <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2479\">recessive<\/a> to one another. Instead, they are codominant.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2544\">Codominance<\/a><\/strong>\u00a0occurs when two alleles for a gene are expressed equally in the phenotype of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2474\">heterozygotes<\/a>. In the case of ABO blood type, AB heterozygotes have a unique phenotype, with both A and B antigens in their blood (type AB blood).<\/p>\n<div>\n<h1>Incomplete Dominance<\/h1>\n<\/div>\n<p>Another relationship that may occur between alleles for the same gene is\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2545\">incomplete dominance<\/a>.<\/strong>\u00a0This occurs when the dominant allele is not completely dominant. In this case, an intermediate phenotype results in heterozygotes who inherit both alleles. Generally, this happens when the two alleles for a given gene both produce\u00a0proteins, but one\u00a0protein\u00a0is not functional. As a result, the heterozygote individual produces only half the amount of normal protein as is produced by an individual who is homozygous for the normal allele.<\/p>\n<p>An example of incomplete dominance in humans is <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/tay-sachs-disease\/symptoms-causes\/syc-20378190\">Tay Sachs disease<\/a>. The normal allele for the gene in this case produces an\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3665\">enzyme<\/a>\u00a0that is responsible for breaking down\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3559\">lipids<\/a>. A defective allele for the gene results in the production of a nonfunctional enzyme. Heterozygotes who have one normal and one defective allele produce half as much functional enzyme as the normal homozygote, and this is enough for normal\u00a0development. Homozygotes who have only defective allele, however, produce only nonfunctional enzyme. This leads to the accumulation of lipids in the brain\u00a0starting\u00a0<em>in utero<\/em>, which causes significant brain damage. Most individuals with Tay Sachs disease die at a young age, typically by the age of five years.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_6216\" aria-describedby=\"caption-attachment-6216\" style=\"width: 551px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-6216 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Incomplete-dominance-hair-1-1.png\" alt=\"5.14.2 Incomplete dominance of hair.\" width=\"551\" height=\"348\"><figcaption id=\"caption-attachment-6216\" class=\"wp-caption-text\"><em>Figure 5.14.3 Three phenotypes of hair through the incomplete dominance model.<\/em><\/figcaption><\/figure>\n<p>Another good example of incomplete dominance in humans is hair type.\u00a0 There are genes for straight and curly hair, and if an individual is heterozygous, they will typically have the phenotype of wavy hair.<\/p>\n<div>\n<h1>Polygenic Traits<\/h1>\n<\/div>\n<figure id=\"attachment_2549\" aria-describedby=\"caption-attachment-2549\" style=\"width: 500px\" class=\"wp-caption alignleft\"><img class=\"size-full wp-image-2549\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Average-height-1.png\" alt=\"Like many other polygenic traits, adult height has a bell-shaped distribution.\" width=\"500\" height=\"363\"><figcaption id=\"caption-attachment-2549\" class=\"wp-caption-text\"><em>Figure 5.14.4 Human Adult Height. Like many other polygenic traits, adult height has a bell-shaped distribution.<\/em><\/figcaption><\/figure>\n<p>Many human traits are controlled by more than one gene. These traits are called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2548\">polygenic traits<\/a><\/strong>. The alleles of each gene have a minor additive effect on the phenotype. There are many possible combinations of alleles, especially if each gene has multiple alleles. Therefore, a whole continuum of phenotypes is possible.<\/p>\n<p>An example of a human polygenic trait is adult height. Several genes, each with more than one allele, contribute to this trait, so there are many possible adult heights. One adult\u2019s height might be 1.655 m (5.430 feet), and another adult\u2019s height might be 1.656 m (5.433 feet). Adult height ranges from less than 5 feet to more than 6 feet, with males, on average, being somewhat taller than females. The majority of people fall near the middle of the range of heights for their sex, as shown in <span style=\"text-align: initial;font-size: 1em\">Figure 5.14.4.<\/span><\/p>\n<div>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Environmental Effects on Phenotype<\/span><\/p>\n<\/div>\n<figure id=\"attachment_2550\" aria-describedby=\"caption-attachment-2550\" style=\"width: 236px\" class=\"wp-caption alignright\"><img class=\"wp-image-2550\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Tan-lines-1.jpg\" alt=\"Image shows a hand with a tan line where a watch had been worn.\" width=\"236\" height=\"236\"><figcaption id=\"caption-attachment-2550\" class=\"wp-caption-text\"><em>Figure 5.14.5 Due to the effects of UV radiation, the skin on the upper part of the arm is much darker in color than the\u00a0 skin that was protected by a watch strap.<\/em><\/figcaption><\/figure>\n<p>Many traits are affected by the environment, as well as by genes. This may be especially true for polygenic traits. Adult height, for example, might be negatively impacted by poor diet or childhood illness. Skin color is another polygenic trait. There is a wide range of skin colors in people worldwide. In addition to differences in genes, differences in exposure to ultraviolet (UV) light cause some variation. As shown in Figure 5.14.5, exposure to UV light darkens the skin.<\/p>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<div>\n<h1>Pleiotropy<\/h1>\n<\/div>\n<p>Some genes affect more than one phenotypic trait. This is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2552\">pleiotropy<\/a><\/strong>. There are numerous examples of pleiotropy in humans. They generally involve important\u00a0proteins\u00a0that are needed for the normal\u00a0development\u00a0or functioning of more than one organ system. An example of\u00a0pleiotropy in humans occurs with the gene that codes for the main\u00a0protein\u00a0in collagen, a substance that helps form\u00a0bones. This protein is also important in the ears and\u00a0eyes.\u00a0Mutations\u00a0in the gene result in problems not only in bones, but also in these sensory organs, which is how the gene's pleiotropic effects were discovered.<\/p>\n<p>Another example of pleiotropy occurs with <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/sickle-cell-anemia\/symptoms-causes\/syc-20355876\">sickle cell anemia<\/a>. This recessive genetic disorder occurs when there is a mutation in the gene that normally encodes the red blood cell <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3721\">protein<\/a> called hemoglobin. People with the disorder have two alleles for sickle cell hemoglobin, so named for the sickle shape (pictured in Figure 5.14.6) that their red blood cells take on under certain conditions (like physical exertion). The sickle-shaped red blood cells clog small blood vessels, causing multiple phenotypic effects, including stunting of physical growth, certain bone deformities, kidney failure, and strokes.<\/p>\n<figure id=\"attachment_2553\" aria-describedby=\"caption-attachment-2553\" style=\"width: 385px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2553\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Sickle-cell-anemia-1.jpg\" alt=\"Image shows the difference in morphology between a sickle cell and a normal red blood cell.\" width=\"385\" height=\"434\"><figcaption id=\"caption-attachment-2553\" class=\"wp-caption-text\"><em>Figure 5.14.6 For comparison, the sickle-shaped red blood cell on the left is shown next to several normal red blood cells.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Epistasis<\/span><\/p>\n<\/div>\n<p>Some genes affect the expression of other genes. This is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3901\">epistasis<\/a><\/strong>. Epistasis is similar to dominance, except that it occurs between different genes, rather than between different alleles for the same gene.<\/p>\n<p>Albinism is an example of epistasis. A person with albinism has virtually no pigment in the skin. The condition occurs due to an entirely different gene than the genes that encode skin\u00a0color. Albinism occurs because a protein called tyrosinase, which is needed for the\u00a0production of normal skin pigment, is not produced, due to a gene\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2381\">mutation<\/a>.\u00a0If an individual has the albinism\u00a0mutation, he or she will not have any skin pigment, regardless of the skin color genes that were inherited.<\/p>\n<div>\n<h3>Feature: My\u00a0Human Body<\/h3>\n<\/div>\n<p>Do you know your ABO blood type? In an emergency, knowing this valuable piece of information could possibly save your life. If you ever need a blood transfusion, it is vital that you receive blood that matches your own blood type. Why? If the blood transfused into your body contains an antigen that your own blood does not contain, antibodies in your blood\u00a0plasma\u00a0(the\u00a0liquid\u00a0part of your blood) will recognize the antigen as foreign to your body and cause a reaction called agglutination. In this reaction, the transfused red blood\u00a0cells will clump together. The agglutination reaction is serious and potentially fatal.<\/p>\n<p>Knowing the antigens and antibodies present in each of the ABO blood types will help you understand which type(s) of blood you can safely receive if you ever need a transfusion. This information is shown in Figure 5.14.7 for all of the ABO blood types. If you have blood type A, this means that your red blood cells have the A antigen and that your blood plasma contains anti-B antibodies. If you were to receive a transfusion of type B or type AB blood, both of which have the B antigen, your anti-B antibodies would attack the transfused red blood cells, causing agglutination.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_2555\" aria-describedby=\"caption-attachment-2555\" style=\"width: 553px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2555\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/ABO_blood_type.svg_-1.png\" alt=\"Image shows a table of each blood type, which antigens and antibodies are present, and acceptable blood donor types.\" width=\"553\" height=\"356\"><figcaption id=\"caption-attachment-2555\" class=\"wp-caption-text\"><em>Figure 5.14.7 Antigens and antibodies in ABO blood types.<\/em><\/figcaption><\/figure>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<p>You may have heard that people with blood type O are called \"universal donors,\" and that people with blood type AB are called universal recipients. People with type O blood have neither A nor B antigens in their blood, so if their blood is transfused into someone with a different ABO blood type, it causes no immune reaction, meaning they can donate blood to anyone. On the other hand, people with type AB blood have no anti-A or anti-B antibodies in their blood, so they can receive a transfusion of blood from anyone. Which blood type(s) can safely receive a transfusion of type AB blood, and which blood type(s) can be safely received by those with type O blood?<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.14 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2537\">Non-Mendelian inheritance<\/a> refers to the inheritance of traits that have a more complex genetic basis than one <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3429\">gene<\/a> with two <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3357\">alleles<\/a> and complete <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3879\">dominance<\/a>.<\/li>\n<li>Multiple allele traits are controlled by a single gene with more than two alleles. An example of a human multiple allele trait is ABO blood type, for which there are three common alleles: A, B, and O.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2544\">Codominance<\/a> occurs when two alleles for a gene are expressed equally in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2477\">phenotype<\/a> of heterozygotes. A human example of codominance also occurs in the ABO blood type, in which the A and B alleles are codominant.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2545\">Incomplete dominance<\/a> is the case in which the dominant allele for a gene is not completely dominant to a recessive allele for the gene, so an intermediate phenotype occurs in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2474\">heterozygotes<\/a> who inherit both alleles. A human example of incomplete dominance is Tay Sachs disease, in which heterozygotes produce half as much functional\u00a0enzyme\u00a0as normal homozygotes.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2548\">Polygenic traits<\/a> are controlled by more than one gene, each of which has a minor additive effect on the phenotype. This results in a whole continuum of phenotypes. Examples of human polygenic traits include skin color and adult\u00a0height.<\/li>\n<li>Many traits are affected by\u00a0the environment, as well as by genes. This may be especially true for polygenic traits.\u00a0Skin color, for example, may be affected by exposure to UV light, and adult stature may be affected by diet or\u00a0childhood\u00a0disease.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2552\">Pleiotropy<\/a> refers to the situation in which a gene affects more than one phenotypic trait. A human example of pleiotropy occurs with sickle cell anemia. People who inherit two <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2479\">recessive<\/a> alleles for this disorder have abnormal red blood cells and may exhibit multiple other phenotypic effects, such as stunting of physical growth, kidney failure, and strokes.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3901\">Epistasis<\/a> is the situation in which one gene affects the expression of other genes. An example of epistasis is albinism, in which the albinism mutation negates the expression of skin color genes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.14 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is non-Mendelian inheritance?<\/li>\n<li>\n<div id=\"h5p-76\">\n<div class=\"h5p-content\" data-content-id=\"76\"><\/div>\n<\/div>\n<\/li>\n<li>Explain why the human ABO blood group is an example of a multiple allele trait with codominance.<\/li>\n<li>What is incomplete dominance? Give an example of this type of non-Mendelian inheritance in humans.<\/li>\n<li>Explain the genetic basis of human skin color.<\/li>\n<li>How can the human trait of adult height be influenced by the environment?<\/li>\n<li>Define pleiotropy, and give a human example.<\/li>\n<li>Compare and contrast epistasis and dominance.<\/li>\n<li>What is the difference between pleiotropy and epistasis?<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">5.14 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?time_continue=1&amp;v=YJHGfbW55l0&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Incomplete Dominance, Codominance, Polygenic Traits, and Epistasis!,<br \/>\nAmoeba Sisters, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=-4vsio8TZrU&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Non-Mendelian Genetics, Teacher's Pet, 2015.<\/p>\n<\/div>\n<\/div>\n<h2>Attributes<\/h2>\n<p><strong>Figure 5.14.1<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/unsplash.com\/s\/photos\/portraits\">Woman's Face from Iran<\/a> by <span class=\"_1JARO\"><a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@omidarmin\">Omid Armin<\/a><\/span> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/7ip-IOC2yvA\">Woman Wearing Black Coat<\/a> by <a href=\"https:\/\/unsplash.com\/@pinkkilla\">Anastasiya Pavlova<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><span style=\"background-color: #ffffff\"><a class=\"_2RL3a xLon9\" style=\"background-color: #ffffff\" href=\"https:\/\/unsplash.com\/photos\/jns8BPueAgU\"><span class=\"_20NLS _1ByhS\">Dark haired man, Queretaro, M\u00e9xico<\/span><\/a> by <span class=\"_1JARO\"><a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@ldhai\">Leonel Hernandez Arteaga<\/a><\/span> on <a style=\"background-color: #ffffff\" href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" style=\"background-color: #ffffff\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license). &lt;not found on Unsplash&gt;<\/span><\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/iFgRcqHznqg\">Man in White V-Neck T-Shirt (self)<\/a> by <a href=\"https:\/\/unsplash.com\/@miracletwentyone\">Joseph Gonzalez<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/u3WmDyKGsrY\">Natural Redhead in Brazil<\/a> by <a href=\"https:\/\/unsplash.com\/@eugabrielsilverio\">Gabriel Silv\u00e9rio<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/www.instagram.com\/p\/CBhxlohnSeJ\/\">Dark-Skinned Woman with Large White Rose<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@oladimeg\">Oladimeji Oduns<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<\/ul>\n<p><strong>Figure 5.14.2<\/strong><\/p>\n<p>ABO Blood Types Per Genotype by Christine Miller is released into the <a href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 5.14.3<\/strong><\/p>\n<p>Three Phenotypes of Hair Based on Inheritance\/ <span style=\"font-size: 1em\">Incomplete Dominance<\/span><span style=\"text-align: initial;font-size: 1em\"> Hair <\/span><span style=\"text-align: initial;font-size: 1em\">by Christine Miller is released into the <\/span><a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 5.14.4<\/strong><\/p>\n<p><a href=\"https:\/\/dr282zn36sxxg.cloudfront.net\/datastreams\/f-d%3Ad83f2c6640f7e493d532f370dbf49bb6a23ea2f578b553130dea2ad1%2BIMAGE_THUMB_POSTCARD_TINY%2BIMAGE_THUMB_POSTCARD_TINY.1\" rel=\"cc:attributionURL\">Average height \/Human Adult Height<\/a> by <a href=\"https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/5.13\/\">CK-12 Foundation<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.<\/p>\n<p><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em\">Licensed under\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/p>\n<p><strong>Figure 5.14.5<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/katiebordner\/15010445032\" rel=\"cc:attributionURL\">Tan lines<\/a> by <a class=\"owner-name truncate\" title=\"Go to katiebordner's photostream\" href=\"https:\/\/www.flickr.com\/photos\/katiebordner\/\" data-track=\"attributionNameClick\">katiebordner<\/a>\u00a0on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <span style=\"text-align: initial;font-size: 1em\">\u00a0<\/span><a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/p>\n<p><strong>Figure 5.14.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:1911_Sickle_Cells.jpg\" rel=\"cc:attributionURL\">Sickle cell anemia<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/18-3-erythrocytes\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) \u00a9<\/p>\n<p><strong style=\"text-align: initial;font-size: 1em\">Figure 5.14.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:ABO_blood_type.svg\" rel=\"cc:attributionURL\">ABO_blood_type.svg<\/a> by <a class=\"new\" title=\"User:InvictaHOG (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:InvictaHOG&amp;action=edit&amp;redlink=1\">InvictaHOG<\/a> on Wikimedia Commons is in the <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2015, May 25). Incomplete dominance, codominance, polygenic traits, and epistasis! YouTube. https:\/\/www.youtube.com\/watch?v=YJHGfbW55l0<\/p>\n<p class=\"hanging-indent\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, April 25). Figure 18.9 Sickle cells [digital image]. In <em>Anatomy and Physiology<\/em>. OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/18-3-erythrocytes<\/p>\n<p class=\"hanging-indent\">Brainard, J\/ CK-12 Foundation. (2016). Figure 2 Human adult height [digital image]. In <em>CK-12 College Human Biology<\/em> (Section 5.13) [online Flexbook]. CK12.org. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/5.13\/<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Tay-Sachs disease [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/tay-sachs-disease\/symptoms-causes\/syc-20378190<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Sickle cell anemia [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/sickle-cell-anemia\/symptoms-causes\/syc-20355876<\/p>\n<p class=\"hanging-indent\">Teacher's Pet. (2015, January 25). Non-mendelian genetics. YouTube. https:\/\/www.youtube.com\/watch?v=-4vsio8TZrU<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_2987\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_2987\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_1132\" aria-describedby=\"caption-attachment-1132\" style=\"width: 640px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1131 size-full\" title=\"Botox, he whispered by Michael Reuter\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Botox-joke.jpg\" alt=\"12.7 Botox Joke\" width=\"640\" height=\"225\"><figcaption id=\"caption-attachment-1132\" class=\"wp-caption-text\"><em>Figure 12.7.1 The botox effect.\u00a0<\/em><\/figcaption><\/figure>\n<div>\n<h1>Case Study Conclusion: Needing to Relax<\/h1>\n<\/div>\n<p>As you learned in the beginning of this chapter, botulinum toxin \u2014 one form of which is sold under the brand name <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4150\">Botox<\/a> \u2014 does much more than smooth out wrinkles. It can be used to treat a number of disorders involving excessive muscle contraction, including cervical dystonia. You also\u00a0learned that cervical dystonia, which Edward suffers from, causes abnormal, involuntary muscle contractions of the neck. This results in jerky movements of the head and neck, and\/or a sustained abnormal tilt to the head. It is often painful and can significantly interfere with a person\u2019s life.<\/p>\n<figure id=\"attachment_1132\" aria-describedby=\"caption-attachment-1132\" style=\"width: 432px\" class=\"wp-caption alignleft\"><img class=\"wp-image-1132\" title=\"botulism by Jason Wilson\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Botulism-by-Jason-Wilson-on-flickr.jpg\" alt=\"12.7 Botulism joke\" width=\"432\" height=\"325\"><figcaption id=\"caption-attachment-1132\" class=\"wp-caption-text\"><em>Figure 12.7.2 These pickles are jokingly labeled \"botulism,\" but <\/em>actual <em>botulism is really no joke.<\/em><\/figcaption><\/figure>\n<p>How could a toxin actually\u00a0<em>help<\/em>\u00a0treat a muscular disorder? The botulinum toxin is produced by the soil bacterium,\u00a0<em>Clostridium botulinum<\/em>, and it is the cause of the potentially deadly disease called botulism. Botulism is often a foodborne illness, commonly caused by foods that are improperly canned. Other forms of botulism are caused by wound infections, or occur when infants consume spores of the bacteria from soil or honey.<\/p>\n<div><\/div>\n<p>Botulism can be life-threatening, because it paralyzes muscles throughout the body, including those involved in breathing. When a very small amount of botulinum toxin is injected carefully into specific muscles by a trained medical professional, however, it can be useful in inhibiting unwanted muscle contractions.<\/p>\n<p>For cosmetic purposes, botulinum toxin injected into the facial muscles relaxes them to reduce the appearance of wrinkles. When used to treat cervical dystonia, it is injected into the muscles of the neck to inhibit excessive muscle contractions. For many patients, this helps relieve the abnormal positioning, movements, and pain associated with the disorder. The effect is temporary, so the injections must be repeated every three to four months to keep the symptoms under control.<\/p>\n<p>How does botulinum toxin inhibit muscle contraction? First, recall how skeletal muscle contraction works. A motor neuron instructs skeletal muscle fibres to contract at a synapse between them called the neuromuscular junction. A nerve impulse called an action potential travels down to the axon terminal of the motor neuron, where it causes the release of the neurotransmitter acetylcholine (ACh) from synaptic vesicles. The ACh travels across the synaptic cleft and binds to ACh receptors on the muscle fibre, signaling the muscle fibre to contract. According to the sliding filament theory, the contraction of the muscle fibre occurs due to the sliding of myosin and actin filaments across each other. This causes the Z discs of the sacromeres to move closer together, shortening the sacromeres and causing the muscle fibre to contract.<\/p>\n<p>If you wanted to inhibit muscle contraction, at what points could you theoretically interfere with this process? Inhibiting the action potential in the motor neuron, the release of ACh, the activity of ACh receptors, or the sliding filament process in the muscle fibre would all theoretically impair this process and inhibit muscle contraction. For example, in the disease myasthenia gravis, the function of the ACh receptors is impaired, causing a lack of sufficient muscle contraction. As you have learned, this results in muscle weakness that can eventually become life-threatening. Botulinum toxin works by inhibiting the release of ACh from the motor neurons, thereby removing the signal instructing the muscles to contract.<\/p>\n<p>Fortunately, Edward\u2019s excessive muscle contractions and associated pain improved significantly thanks to botulinum toxin injections. Although cervical dystonia cannot currently be cured, botulinum toxin injections have improved the quality of life for many patients with this and other disorders involving excessive involuntary muscle contractions.<\/p>\n<p>As you have learned in this chapter, our muscular system allows us to do things like make voluntary movements, digest our food, and pump blood through our bodies. Whether they are in your arm, heart, stomach, or blood vessels, muscle tissue works by contracting. But as you have seen here, too much contraction can be a very bad thing. Fortunately, scientists and physicians have found a way to put a potentially deadly toxin \u2014 and wrinkle-reducing treatment \u2014 to excellent use as a medical treatment for some muscular system disorders.<\/p>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter 12 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In this chapter, you learned about the muscular system. Specifically, you learned that:<\/p>\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2907\">muscular system<\/a> consists of all the muscles of the body. There are three types of muscle: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2981\">skeletal muscle<\/a> (which is attached to bones by tendons and enables voluntary body movements), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2568\">cardiac muscle<\/a> (which makes up the walls of the heart and makes it beat) and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2982\">smooth muscle<\/a> (which is found in the walls of internal organs and other internal structures and controls their movements).<\/li>\n<li>Muscles are organs composed mainly of muscle cells, which may also be called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4156\">muscle fibres<\/a> or <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4157\">myocytes<\/a>. Muscle cells are specialized for the function of contracting, which occurs when protein filaments inside the cells slide over one another using energy from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2072\">ATP<\/a>. Muscle tissue is the only type of tissue that has cells with the ability to contract.<\/li>\n<li>Muscles can grow larger, or <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4159\">hypertrophy<\/a>. This generally occurs through increased use, although hormonal or other influences can also play a role. Muscles can also grow smaller, or <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4160\">atrophy<\/a>. This may occur through lack of use, starvation, certain diseases, or aging. In both hypertrophy and atrophy, the size \u2014 but not the number \u2014 of muscle fibres changes. The size of muscles is the main determinant of muscle strength.<\/li>\n<li>Skeletal muscles need the stimulus of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3031\">motor neurons<\/a>\u00a0to contract, and to move the body, they need the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2906\">skeletal system<\/a> to act upon.<\/li>\n<li>Skeletal muscle\u00a0is the most common type of muscle tissue in the human body.\u00a0To move bones in opposite directions, skeletal muscles often consist of pairs of muscles that work in opposition to one another to move bones in different directions at <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3949\">joints<\/a>.<\/li>\n<li>Skeletal muscle fibres are bundled together in units called muscle fascicles, which are bundled together to form individual skeletal muscles. Skeletal muscles also have connective tissue supporting and protecting the muscle tissue.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Each skeletal muscle fibre consists of a bundle of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4180\">myofibrils<\/a>, which are bundles of protein filaments. The filaments are arranged in repeating units called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4179\">sarcomeres<\/a>, which are the basic functional units of skeletal muscles. Skeletal muscle tissue is striated, because of the pattern of sarcomeres in its fibres.<\/li>\n<li>Skeletal muscle fibres can be divided into two types, called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4184\">slow-twitch<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4185\">fast-twitch<\/a> fibres. Slow-twitch fibres are used mainly in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_1796\">aerobic<\/a> endurance activities (such as long-distance running). Fast-twitch fibres are used mainly for non-aerobic, strenuous activities (such as sprinting). Proportions of the two types of fibres vary from muscle to muscle and person to person.<\/li>\n<\/ul>\n<\/li>\n<li>Smooth muscle tissue is found in the walls of internal organs and vessels. When smooth muscles contract, they help the organs and vessels carry out their functions. The pattern of smooth muscle contraction to move substances through body tubes is called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2890\">peristalsis<\/a>.\u00a0 Contractions of smooth muscles are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3005\">involuntary<\/a> and controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2533\">autonomic nervous system<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2218\">hormones<\/a>, and other substances.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Cells of smooth muscle tissue are not striated because they lack sarcomeres, but the cells contract in the same basic way as striated muscle cells. Unlike striated muscle, smooth muscle can sustain very long-term contractions and maintain its contractile function, even when stretched.<\/li>\n<\/ul>\n<\/li>\n<li>Cardiac muscle tissue is found only in the wall of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2987\">heart<\/a>. When cardiac muscle contracts, the heart beats and pumps blood. Contractions of cardiac muscle are involuntary, like those of smooth muscles. They are controlled by electrical impulses from specialized cardiac cells.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Like skeletal muscle, cardiac muscle is striated because its filaments are arranged in sarcomeres.\u00a0The exact arrangement, however, differs, making cardiac and skeletal muscle tissues look different from one another.<\/li>\n<li>The heart is the muscle that performs the greatest amount of physical work in the course of a lifetime. Its cells contain a great many <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2383\">mitochondria<\/a> to produce ATP for energy and to help the heart resist fatigue.<\/li>\n<\/ul>\n<\/li>\n<li>A muscle contraction is an increase in the tension or a decrease in the length of a muscle. A muscle contraction is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4207\">isometric<\/a> if muscle tension changes, but muscle length remains the same. It is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4208\">isotonic<\/a> if muscle length changes, but muscle tension remains the same.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>A skeletal muscle contraction begins with electrochemical stimulation of a muscle fibre by a motor neuron. This occurs at a chemical synapse called a neuromuscular junction. The neurotransmitter acetylcholine diffuses across the synaptic cleft and binds to receptors on the muscle fibre. This initiates a muscle contraction.<\/li>\n<li>Once stimulated, the protein filaments within the skeletal muscle fibre slide past each other to produce a contraction. The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4212\">sliding filament theory<\/a> is the most widely accepted explanation for how this occurs. According to this theory, thick <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4182\">myosin<\/a> filaments repeatedly attach to and pull on thin <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4181\">actin<\/a> filaments, thus shortening sarcomeres.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4214\">Crossbridge cycling<\/a> is a cycle of molecular events that underlies the sliding filament theory. Using energy in ATP, myosin heads repeatedly bind with and pull on actin filaments. This moves the actin filaments toward the center of a sarcomere, shortening the sarcomere and causing a muscle contraction.<\/li>\n<li>The ATP needed for a muscle contraction comes first from ATP already available in the cell, and more is generated from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4217\">creatine phosphate<\/a>. These sources are quickly used up. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_1945\">Glucose<\/a> and glycogen can be broken down to form ATP and pyruvate. Pyruvate can then be used to produce ATP in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2502\">aerobic respiration<\/a> if oxygen is available, or it can be used in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2163\">anaerobic respiration<\/a> if oxygen is not available.<\/li>\n<\/ul>\n<\/li>\n<li>Physical exercise is defined as any bodily activity that enhances or maintains physical fitness and overall health. Activities such as household chores may even count as physical exercise! Current recommendations for adults are 30 minutes of moderate exercise a day.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4225\">Aerobic exercise<\/a> is any physical activity that uses muscles at less than their maximum contraction strength, but for long periods of time. This type of exercise uses a relatively high percentage of slow-twitch muscle fibres that consume large amounts of oxygen. Aerobic exercises increase cardiovascular endurance, and include cycling and brisk walking.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4226\">Anaerobic exercise<\/a> is any physical activity that uses muscles at close to their maximum contraction strength, but for short periods of time. This type of exercise uses a relatively high percentage of fast-twitch muscle fibres that consume small amounts of oxygen. Anaerobic exercises increase muscle and bone mass and strength, and they include push-ups and sprinting.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4228\">Flexibility exercise<\/a> is any physical activity that stretches and lengthens muscles, thereby improving range of motion and reducing risk of injury. Examples include stretching and yoga.<\/li>\n<li>Many studies have shown that physical exercise is positively correlated with a diversity of physical, mental, and emotional health benefits. Physical exercise also increases quality of life and life expectancy.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Many of the benefits of exercise may come about because contracting muscles release hormones called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4230\">myokines<\/a>, which promote tissue repair and growth and have anti-inflammatory effects.<\/li>\n<li>Physical exercise can reduce risk factors for cardiovascular disease, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4231\">hypertension<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4243\">excess body weight<\/a>. Physical exercise can also increase factors associated with cardiovascular health, such as mechanical efficiency of the heart.<\/li>\n<li>Physical exercise has been shown to offer protection from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4233\">dementia<\/a> and other cognitive problems, perhaps because it increases blood flow or neurotransmitters in the brain, among other potential effects.<\/li>\n<li>Numerous studies suggest that regular aerobic exercise works as well as pharmaceutical antidepressants in treating mild-to-moderate <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4237\">depression<\/a>, possibly because it increases synthesis of natural <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4239\">euphoriants<\/a>\u00a0in the brain.<\/li>\n<li>Research shows that physical exercise generally improves sleep for most people, and helps sleep disorders, such as insomnia. Other health benefits of physical exercise include better immune system function and reduced risk of type 2 diabetes and obesity.<\/li>\n<\/ul>\n<\/li>\n<li>There is great variation in individual responses to exercise, partly due to genetic differences in proportions of slow-twitch and fast-twitch muscle fibres. People with more slow-twitch fibres may be able to develop greater endurance from aerobic exercise, whereas people with more fast-twitch fibres may be able to develop greater muscle size and strength from anaerobic exercise.<\/li>\n<li>Some adverse effects may occur if exercise is extremely intense and the body is not given proper rest between exercise sessions. Many people who overwork their muscles develop delayed onset muscle soreness (DOMS), which may be caused by tiny tears in muscle fibres.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4253\">Musculoskeletal disorders<\/a>\u00a0are injuries that occur in muscles or associated tissues (such as tendons) because of biomechanical stresses. The disorders may be caused by sudden exertion, over-exertion, repetitive motions, and similar stresses.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>A <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4255\">muscle strain<\/a> is an injury in which muscle fibres tear as a result of overstretching. First aid for a muscle strain includes the five steps represented by the acronym PRICE (protection, rest, ice, compression, and elevation). Medications for inflammation and pain (such as NSAIDs) may also be used.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4257\">Tendinitis<\/a> is inflammation of a tendon that occurs when it is over-extended or worked too hard without rest. Tendinitis may also be treated with PRICE and NSAIDs.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4258\">Carpal tunnel syndrome<\/a> is a biomechanical problem that occurs in the wrist when the median nerve becomes compressed between carpal bones. It may occur with repetitive use, a tumor, or trauma to the wrist. It may cause pain, numbness, and eventually \u2014 if untreated \u2014 muscle wasting in the thumb and first two fingers of the hand.<\/li>\n<\/ul>\n<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4254\">Neuromuscular disorders<\/a>\u00a0are systemic disorders that occur because of problems with the nervous control of muscle contractions, or with the muscle cells themselves.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4260\">Muscular dystrophy<\/a> is a genetic disorder caused by defective proteins in muscle cells. It is characterized by progressive skeletal muscle weakness and death of muscle tissues.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4262\">Myasthenia gravis<\/a> is a genetic neuromuscular disorder characterized by fluctuating muscle weakness and fatigue. More muscles are affected, and muscles become increasingly weakened as the disorder progresses. Myasthenia gravis most often occurs because immune system antibodies block acetylcholine receptors on muscle cells, and because of the actual loss of acetylcholine receptors.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4264\">Parkinson\u2019s disease<\/a> is a degenerative disorder of the central nervous system that mainly affects the muscular system and movement. It occurs because of the death of neurons in the midbrain. Characteristic signs of the disorder are muscle tremor, muscle rigidity, slowness of movement, and postural instability. Dementia and depression also often characterize advanced stages of the disease.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>As you saw in this chapter, muscles need oxygen to provide enough ATP for most of their activities. In fact, all of the body\u2019s systems require oxygen, and also need to remove waste products, such as carbon dioxide. In the next chapter, you will learn about how the respiratory system obtains and distributes oxygen throughout the body, as well as\u00a0how it removes\u00a0wastes, such as carbon dioxide.<\/p>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter 12 Review<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-233\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-233\" class=\"h5p-iframe\" data-content-id=\"233\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Chapter 12 Review Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What are tendons? Name a muscular system disorder involving tendons<\/li>\n<li>Describe the relationship between muscles, muscle fibres, and fascicles.<br \/>\n<img class=\"alignnone wp-image-1134\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Biceps_PSF.jpg\" alt=\"\" width=\"178\" height=\"223\"><\/li>\n<li>The biceps and triceps muscles are shown above. Answer the following questions about these arm muscles.\n<ol type=\"a\">\n<li>When the biceps contract and become shorter (as in the picture above), what kind of motion does this produce in the arm?<\/li>\n<li>Is the situation described in part (a) more likely to be an isometric or isotonic contraction? Explain your answer.<\/li>\n<li>If the triceps were to then contract, which way would the arm move?<\/li>\n<\/ol>\n<\/li>\n<li>What are Z discs? What happens to them during muscle contraction?<\/li>\n<li>What is the function of mitochondria in muscle cells? Which type of muscle fibre has more mitochondria \u00ad\u2014 slow-twitch or fast-twitch?<\/li>\n<li>What is the difference between primary and secondary Parkinson\u2019s disease?<\/li>\n<li>Why can carpal tunnel syndrome cause muscle weakness in the hands?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 12.7.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/michaelreuter\/5409410945\">Botox, he whispered<\/a> by <a class=\"owner-name truncate\" title=\"Go to Michael Reuter's photostream\" href=\"https:\/\/www.flickr.com\/photos\/michaelreuter\/\" data-track=\"attributionNameClick\">Michael Reuter<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/p>\n<p><strong>Figure 12.7.2<\/strong><\/p>\n<p><a style=\"font-size: 1em\" href=\"https:\/\/www.flickr.com\/photos\/hive\/2962297451\">botulism<\/a><span style=\"font-size: 1em\">\u00a0<\/span>by <a class=\"owner-name truncate no-outline\" title=\"Go to jason wilson's photostream\" href=\"https:\/\/www.flickr.com\/photos\/hive\/\" data-track=\"attributionNameClick\">jason wilson<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/p>\n<h2>Reference<\/h2>\n<p class=\"hanging-indent\">Pearson Scott Foresman. (2020, April 14). File:Biceps (PSF).jpg [digital image]. <i>Wikimedia Commons.<\/i>\u00a0https:\/\/commons.wikimedia.org\/w\/index.php?title=File:Biceps_(PSF).jpg&amp;oldid=411251538. [Public Domain (https:\/\/en.wikipedia.org\/wiki\/Public_domain)]<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_2990\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_2990\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_1198\" aria-describedby=\"caption-attachment-1198\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1195\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Oxygen-Bar-by-Farrukh-on-flickr.jpg\" alt=\"13.4.1 Oxygen Bar\" width=\"400\" height=\"226\"><figcaption id=\"caption-attachment-1198\" class=\"wp-caption-text\"><em>Figure 13.4.1 Would you pay for air?<\/em><\/figcaption><\/figure>\n<div>\n<h1>Oxygen Bar<\/h1>\n<\/div>\n<p>Belly up to the bar and get your favorite... oxygen? That\u2019s right \u2014 in some cities, you can get a shot of pure oxygen, with or without your choice of added flavors. Bar patrons inhale oxygen through a plastic tube inserted into their nostrils, paying up to a dollar per minute to inhale the pure gas. Proponents of the practice claim that breathing in extra oxygen will remove toxins from the body, strengthen the immune system, enhance concentration and alertness, increase energy, and even cure cancer!\u00a0These claims, however, have not been substantiated by controlled scientific studies. Normally, blood leaving the lungs is almost completely saturated with oxygen, even without the use of extra oxygen, so it\u2019s unlikely that a higher concentration of oxygen in air inside the lungs would lead to significantly greater oxygenation of the blood. Oxygen enters the blood in the lungs as part of the process of gas exchange.<\/p>\n<div>\n<h1>What is Gas Exchange?<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4288\">Gas exchange<\/a><\/strong>\u00a0is the biological process through which gases are transferred across cell membranes to either enter or leave the blood. Oxygen is constantly needed by cells for aerobic cellular respiration, and the same process continually produces carbon dioxide as a waste product. Gas exchange takes place between the blood and cells throughout the body, with oxygen leaving the blood and entering the cells, and carbon dioxide leaving the cells and entering the blood. Gas exchange also takes place between the blood and the air in the lungs, with oxygen entering the blood from the inhaled air inside the lungs, and carbon dioxide leaving the blood and entering the air to be exhaled from the lungs.<\/p>\n<div>\n<h1>Gas Exchange in the Lungs<\/h1>\n<\/div>\n<p>Alveoli are the basic functional units of the lungs where gas exchange takes place between the air and the blood.<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4311\">\u00a0<strong>Alveoli (singular, alveolus)<\/strong><\/a> are tiny air sacs that consist of connective and epithelial tissues. The connective tissue includes elastic fibres that allow alveoli to stretch and expand as they fill with air during inhalation. During exhalation, the fibres allow the alveoli to spring back and expel the air. Special cells in the walls of the alveoli secrete a film of fatty substances called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4339\"><strong>surfactant<\/strong><\/a>. This substance prevents the alveolar walls from collapsing and sticking together when air is expelled. Other cells in alveoli include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4340\">macrophage<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">, which are mobile scavengers that engulf and destroy foreign particles that manage to reach the lungs in inhaled air.<\/span><\/p>\n<p>As shown in Figure 13.4.2, alveoli are arranged in groups like clusters of grapes. Each alveolus is covered with epithelium that is just one cell thick. It is surrounded by a bed of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4341\">pulmonary<\/a> capillaries, each of which has a wall of epithelium just one cell thick. As a result, gases must cross through only two cells to pass between an alveolus and its surrounding capillaries.<\/p>\n<figure id=\"attachment_1198\" aria-describedby=\"caption-attachment-1198\" style=\"width: 519px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1196\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Alveolus_diagram.svg_.png\" alt=\"13.4.2 Alveolus Diagram\" width=\"519\" height=\"393\"><figcaption id=\"caption-attachment-1198\" class=\"wp-caption-text\"><em>Figure 13.4.2 Clusters of alveolar sacs make up most of the functional tissue of the lungs. Note that in this and subsequent illustrations, arteries, which carry oxygenated blood, are colored red; and veins, which carry deoxygenated blood, are colored blue.<\/em><\/figcaption><\/figure>\n<p>The pulmonary artery (also shown in Figure 13.4.2) carries deoxygenated blood from the heart to the lungs. Then, the blood travels through the pulmonary capillary beds, where it picks up oxygen and releases carbon dioxide. The oxygenated blood then leaves the lungs and travels back to the heart through pulmonary veins. There are four pulmonary veins (two for each lung), and all four carry oxygenated blood to the heart. From the heart, the oxygenated blood is then pumped to cells throughout the body.<\/p>\n<div>\n<h1>Mechanism of Gas Exchange<\/h1>\n<\/div>\n<p>Gas exchange occurs by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_1655\">diffusion<\/a> across cell membranes. Gas molecules naturally move down a concentration gradient from an area of higher concentration to an area of lower concentration. This is a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2276\">passive<\/a> process that requires no energy. To diffuse across cell membranes, gases must first be dissolved in a liquid. Oxygen and carbon dioxide are transported around the body dissolved in blood. Both gases bind to the protein hemoglobin in red blood cells, although oxygen does so more effectively than carbon dioxide. Some carbon dioxide also dissolves in blood plasma.<\/p>\n<p>As shown in Figure 13.4.3, oxygen in inhaled air diffuses into a pulmonary capillary from the alveolus. Carbon dioxide in the blood diffuses in the opposite direction. The carbon dioxide can then be exhaled from the body.<\/p>\n<figure id=\"attachment_1198\" aria-describedby=\"caption-attachment-1198\" style=\"width: 695px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1198\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Gas_exchange_in_the_aveolus.svg_.png\" alt=\"13.4.3 Gas Exchange at the Alveolus\" width=\"695\" height=\"565\"><figcaption id=\"caption-attachment-1198\" class=\"wp-caption-text\"><em>Figure 13.4.3 A single alveolus is a tiny structure that is specialized for gas exchange between inhaled air and the blood in pulmonary capillaries.<\/em><\/figcaption><\/figure>\n<p>Gas exchange by diffusion depends on having a large surface area through which gases can pass. Although each alveolus is tiny, there are hundreds of millions of them in the lungs of a healthy adult, so the total surface area for gas exchange is huge. It is estimated that this surface area may be as great as 100 m<sup>2<\/sup> (or approximately 1,076 ft\u00b2). Often we think of lungs as balloons, but this type of structure would have very limited surface area and there wouldn't be enough space for blood to interface with the air in the alveoli.\u00a0 The structure alveoli take in the lungs is more like a giant mass of soap bubbles \u2014\u00a0 millions of tiny little chambers making up one large mass \u2014 this is what increases surface area giving blood lots of space to come into close enough contact to exchange gases by diffusion.<\/p>\n<p>Gas exchange by diffusion also depends on maintaining a steep concentration gradient for oxygen and carbon dioxide. Continuous blood flow in the capillaries and constant breathing maintain this gradient.<\/p>\n<ul>\n<li>Each time you inhale, there is a greater concentration of oxygen in the air in the alveoli than there is in the blood in the pulmonary capillaries. As a result, oxygen diffuses from the air inside the alveoli into the blood in the capillaries. Carbon dioxide, in contrast, is more concentrated in the blood in the pulmonary capillaries than it is in the air inside the alveoli.\u00a0As a result, carbon dioxide diffuses in the opposite direction.<\/li>\n<li>The cells of the body have a much lower concentration of oxygen than does the oxygenated blood that reaches them in peripheral capillaries, which are the capillaries that supply tissues throughout the body. As a result, oxygen diffuses from the peripheral capillaries into body cells. The opposite is true of carbon dioxide. It has a much higher concentration in body cells than it does in the blood of the peripheral capillaries. Thus, carbon dioxide diffuses from body cells into the peripheral capillaries.<\/li>\n<\/ul>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">13.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4288\">Gas exchange<\/a> is the biological process through which gases are transferred across cell membranes to either enter or leave the blood. Gas exchange takes place continuously between the blood and cells throughout the body, and also between the blood and the air inside the lungs.<\/li>\n<li>Gas exchange in the lungs takes place in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_4311\">alveoli<\/a>, which are tiny air sacs surrounded by networks of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2566\">capillaries<\/a>. The pulmonary artery carries deoxygenated blood from the heart to the lungs, where it travels through pulmonary capillaries, picking up oxygen and releasing carbon dioxide. The oxygenated blood then leaves the lungs through pulmonary veins.<\/li>\n<li>Gas exchange occurs by diffusion across cell membranes. Gas molecules naturally move down a concentration gradient from an area of higher concentration to an area of lower concentration. This is a passive process that requires no energy.<\/li>\n<li>Gas exchange by diffusion depends on the large surface area provided by the hundreds of millions of alveoli in the lungs. It also depends on a steep concentration gradient for oxygen and carbon dioxide. This gradient is maintained by continuous blood flow and constant breathing.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">13.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is gas exchange?<\/li>\n<li>Summarize the flow of blood into and out of the lungs for gas exchange.<\/li>\n<li>\n<div id=\"h5p-241\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-241\" class=\"h5p-iframe\" data-content-id=\"241\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"13.4 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Describe the mechanism by which gas exchange takes place.<\/li>\n<li>Identify the two main factors upon which gas exchange by diffusion depends.<\/li>\n<li>If the concentration of oxygen were higher inside of a cell than outside of it, which way would the oxygen flow? Explain your answer.<\/li>\n<li>Why is it important that the walls of the alveoli are only one cell thick?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">13.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=nRpwdwm06Ic&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Oxygen movement from alveoli to capillaries | NCLEX-RN | Khan Academy, khanacademymedicine, 2013.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=KmgIqVwytwA&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">About Carbon Monoxide and Carbon Monoxide Poisoning, EMDPrepare, 2009.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=GVU_zANtroE<\/p>\n<p style=\"text-align: center\">Oxygen\u2019s surprisingly complex journey through your body - Enda Butler, TED-Ed, 2017.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2 style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em\">Attributions<\/h2>\n<p><strong>Figure 13.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/swamibu\/2962027363\/\" rel=\"cc:attributionURL\">Oxygen Bar<\/a> by\u00a0<a href=\"https:\/\/www.flickr.com\/photos\/swamibu\/\" rel=\"dc:creator\">Farrukh<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/\" rel=\"license\">CC BY-NC 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/) license.<\/p>\n<p><strong>Figure 13.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Alveolus_diagram.svg\" rel=\"cc:attributionURL\">Alveolus_diagram.svg<\/a>\u00a0by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats<\/a>] on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 13.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Gas_exchange_in_the_aveolus.svg\" rel=\"cc:attributionURL\">Gas_exchange_in_the_aveolus.svg<\/a> by <a title=\"User:Domdomegg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Domdomegg\">domdomegg<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0) license.<\/p>\n<h2 style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em\">References<\/h2>\n<p class=\"hanging-indent\">EMDPrepare. (2009, December 21). About carbon monoxide and carbon monoxide poisoning. YouTube. https:\/\/www.youtube.com\/watch?v=KmgIqVwytwA&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">khanacademymedicine. (2013, February 25). Oxygen movement from alveoli to capillaries | NCLEX-RN | Khan Academy. YouTube. https:\/\/www.youtube.com\/watch?v=nRpwdwm06Ic&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2017, April 13). Oxygen\u2019s surprisingly complex journey through your body - Enda Butler. YouTube. https:\/\/www.youtube.com\/watch?v=GVU_zANtroE&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_4012\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_4012\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_5997\" aria-describedby=\"caption-attachment-5997\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-5997\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Milk-Mustache-from-Flickr-CC-BY-SA-Cedar-Summit-Farm-1.jpg\" alt=\"6.10.1\" width=\"400\" height=\"267\"><figcaption id=\"caption-attachment-5997\" class=\"wp-caption-text\"><em>Figure 6.10.1 Milk mustache!<\/em><\/figcaption><\/figure>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Got Lactase?<\/span><\/p>\n<p>Do you remember the American \u201cgot milk?\u201d slogan from the 1990s?\u00a0 It was used in advertisements for milk in which celebrities were pictured wearing milk \u201cmustaches.\u201d While the purpose of the \u201cgot milk?\u201d ads was to sell more milk, there is no denying that drinking milk can actually be good for one\u2019s health. Milk is naturally high in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3721\">protein<\/a> and minerals. It can also be low in fat or even fat-free if treated to remove the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3559\">lipids<\/a> that naturally occur in milk. However, before you reach for a tall, cold glass of milk,\u00a0 you might want to ask yourself another question: \u201cgot lactase?\u201d<\/p>\n<div>\n<h1>Adaptation to Lactose<\/h1>\n<\/div>\n<p>Do you drink milk? Or do you avoid drinking milk and consuming milk products because they cause you discomfort? If the latter is the case, then you may have trouble digesting milk.<\/p>\n<h2>Milk, Lactose, and Lactase<\/h2>\n<p>Milk naturally contains\u00a0more than just\u00a0proteins and lipids \u2014 it also contains carbohydrates. Specifically, milk contains the sugar\u00a0<strong>lactose<\/strong>, which is a disaccharide (two-sugar) compound that consists of one molecule each of galactose and glucose, as shown in the structural formula below (Figure 6.8.2). Lactose makes up between two and eight per cent of milk by weight. The exact amount varies both within and between species.<\/p>\n<figure id=\"attachment_2766\" aria-describedby=\"caption-attachment-2766\" style=\"width: 311px\" class=\"wp-caption alignnone\"><img class=\"wp-image-2766\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/1000px-Lactose_Haworth.svg_-1.png\" alt=\"\" width=\"311\" height=\"275\"><figcaption id=\"caption-attachment-2766\" class=\"wp-caption-text\"><em>Figure 6.8.2 Each molecule of lactose consists of one molecule of galactose (left) and one molecule of glucose (right).<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"text-align: initial;font-size: 1em\">Lactose in milk must be broken down into its two component sugars to be absorbed by the small intestine. The enzyme <\/span><strong style=\"text-align: initial;font-size: 1em\">lactase<\/strong><span style=\"text-align: initial;font-size: 1em\"> is needed for this process, as shown in <\/span><span style=\"text-align: initial;font-size: 1em\">Figure 6.8.3<\/span><span style=\"text-align: initial;font-size: 1em\">. Human infants are almost always born with the ability to synthesize lactase. This allows them to readily digest the lactose in their mother\u2019s milk (or infant formula). In the majority of children, however, lactase synthesis begins to decline at about two years of age, and less and less lactase is produced throughout childhood.<\/span><\/p>\n<\/div>\n<figure id=\"attachment_2767\" aria-describedby=\"caption-attachment-2767\" style=\"width: 1024px\" class=\"wp-caption alignnone\"><img class=\"size-full wp-image-2767\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lactase-1.png\" alt=\"\" width=\"1024\" height=\"192\"><figcaption id=\"caption-attachment-2767\" class=\"wp-caption-text\"><em>Figure 6.8.3 The enzyme lactase is needed to break down the milk sugar lactose into its galactose and glucose components.<\/em><\/figcaption><\/figure>\n<h2>Lactose Intolerance<\/h2>\n<p><strong>Lactose intolerance<\/strong>\u00a0is the inability of older children and adults to digest lactose in milk. People who are lactose intolerant may be able to drink small quantities of milk without any problems, but if they try to consume larger amounts, they are likely to suffer adverse effects. For example, they may have abdominal bloating and cramping, flatulence (gas), diarrhea, nausea, and vomiting. The symptoms may occur from 30 minutes\u00a0to two hours after milk is consumed, and\u00a0they're\u00a0generally worse when the quantity of milk consumed is greater. The symptoms result from the small intestine's inability to digest and absorb lactose, so the lactose is passed on to the large intestine, where normal intestinal bacteria start breaking it down through the process of fermentation. This process releases gas and causes the other symptoms of lactose intolerance.<\/p>\n<p>Lactose intolerance is actually the original and normal condition of the human species, as well as\u00a0all other mammalian species. Early humans were hunter-gatherers that subsisted on wild plant and animal foods. The animal foods may have included meat and eggs, but did not include milk because animals had not been domesticated. Therefore, beyond the weaning period, milk was not available for people to drink in early human populations. It makes good biological sense to stop synthesizing an enzyme that the body does not need. After a young child is weaned, it is a waste of materials and energy to keep producing lactase when milk is no longer likely to be consumed.<\/p>\n<p>Overall, an estimated 60 per cent of the world\u2019s adult human population is thought to be lactose intolerant today. You can see the geographic distribution of modern human lactose intolerance on the map in Figure 6.8.4. Lactose intolerance (dark blue) approaches 100 per cent in populations throughout southern South America, southern Africa, and East and Southeast Asia.<\/p>\n<div>\n<figure id=\"attachment_2768\" aria-describedby=\"caption-attachment-2768\" style=\"width: 765px\" class=\"wp-caption alignnone\"><img class=\" wp-image-2768\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lactose-Intolerance-1.png\" alt=\"Worldwide map of Lactose Intolerance\" width=\"765\" height=\"381\"><figcaption id=\"caption-attachment-2768\" class=\"wp-caption-text\"><em>Figure 6.8.4 Worldwide distribution of lactose intolerance in human populations.<\/em><\/figcaption><\/figure>\n<\/div>\n<p>Lactose intolerance is not considered a medical problem, because its symptoms can be avoided by avoiding milk or milk products. Dietary control of lactose intolerance may be a matter of trial and error, however, because different people may be able to consume different quantities of milk or milk products before symptoms occur. If you are lactose intolerant, be aware that low-fat and fat-free milk may contain somewhat more lactose than full-fat milk because the former often have added milk solids that are relatively high in lactose.<\/p>\n<h2>Lactase Persistence<\/h2>\n<p><strong>Lactase persistence<\/strong> is the opposite of lactose intolerance. People who are lactase persistent continue to produce the enzyme lactase beyond infancy and generally throughout life. As a consequence they are able to digest lactose and drink milk at older ages without adverse effects. The map in Figure 6.8.4 can also be read to show where lactase persistence occurs today. Populations with a low percentage of lactose intolerance (including most North Americans and Western and Northern Europeans) have high percentages of lactase-persistent people.<\/p>\n<p>Lactase persistence is a uniquely human trait that is not found in any other mammalian species. Why did lactase persistence evolve in humans? When some human populations began domesticating and keeping herds of animals, animal milk became a potential source of food. Animals such as cows, sheep, goats, camels, and even reindeer (see Figure 6.8.5) can be kept for their milk. These animal milks also contain lactose, so natural selection would be strong for any individuals who kept producing lactase beyond infancy and could make use of this nutritious food. Eventually, the trait of lactase persistence would increase in frequency and come to be the predominant trait in dairying populations.<\/p>\n<figure id=\"attachment_2769\" aria-describedby=\"caption-attachment-2769\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-2769\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Reindeer_herding-1.jpg\" alt=\"\" width=\"400\" height=\"267\"><figcaption id=\"caption-attachment-2769\" class=\"wp-caption-text\"><em>Figure 6.8.5 The Sami were traditionally reindeer herders and their population is nearly 100% lactase persistent. Few Sami still herd reindeer today, but their lactase persistence has persisted.<\/em><\/figcaption><\/figure>\n<p>It is likely that lactase persistence occurs as a result of both genes and environment. Some people inherit genes that help them keep producing lactase after infancy. Geneticists think that several different mutations for lactase persistence arose independently in different populations within the last ten thousand years. Part of lactase persistence may be due to continued exposure to milk in the childhood and adulthood diet. In other words, a person may be genetically predisposed to synthesize lactase at older ages because of a mutation, but they may need the continued stimulation of milk drinking to keep producing lactase.<\/p>\n<div>\n<h1>Thrifty Gene or Drifty Gene?<\/h1>\n<\/div>\n<p>Besides variation in lactase persistence, human populations may vary in how efficiently they use calories in the foods they consume. People in some populations seem able to get by on quantities of food that would be inadequate for others, so they tend to gain weight easily. What explains these differences in people?<\/p>\n<h2>Thrifty Gene Hypothesis<\/h2>\n<p>In 1962, human geneticist <a href=\"https:\/\/en.wikipedia.org\/wiki\/James_V._Neel\">James Neel<\/a> proposed the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2770\">thrifty gene hypothesis<\/a><\/strong>. According to this hypothesis, so-called \u201cthrifty genes\u201d evolved in some human populations because they allowed people to get by on fewer calories and store the rest as body fat when food was plentiful. According to Neel\u2019s hypothesis, thrifty genes would have increased in frequency through natural selection, because they would help people survive during times of famine. People with the genes would be fatter and able to rely on their stored body fat for calories when food was scarce.<\/p>\n<p>Such thrifty genes would have been advantageous in early human populations of hunter-gatherers if food scarcity was a recurrent stress. However, in modern times, when most people have access to enough food year-round, thrifty genes would no longer be advantageous. In fact, under conditions of plentiful food, having thrifty genes would predispose people to gain weight and develop obesity. They would also tend to develop the chronic diseases associated with obesity, particularly type II diabetes.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_2771\">Diabetes mellitus<\/a><\/strong>\u00a0is a disease that occurs when there are problems with the pancreatic hormone\u00a0<strong>insulin,<\/strong>\u00a0which normally helps cells take up glucose from the blood and controls blood glucose levels. In type II diabetes, body cells become relatively resistant to insulin, leading to high blood glucose. This causes symptoms\u00a0like\u00a0excessive thirst and urination. Without treatment, diabetes can lead to serious consequences, such as blindness and kidney failure.<\/p>\n<p>Neel proposed his thrifty gene hypothesis not on the basis of genetic evidence for thrifty genes, but as a possible answer to the mystery of why genes that seem to promote diabetes have not been naturally selected out of some populations. The mystery arose from observations that certain populations \u2014 such as South Pacific Islanders, sub-Saharan Africans, and southwestern Native Americans \u2014 developed high levels of obesity and diabetes after they abandoned traditional diets and adopted Western diets.<\/p>\n<h2>Assessing the Thrifty Gene Hypothesis<\/h2>\n<p>One of the assumptions underlying the thrifty gene hypothesis is that human populations that recently developed high rates of obesity and diabetes after Western contact had a long history of recurrent famine. Anthropological evidence contradicts this assumption for at least some of the populations in question. South Pacific Islanders, for example, have long lived in a \u201cland of plenty,\u201d with lush tropical forests year-round on islands surrounded by warm waters full of fish. Another assumption underlying the thrifty gene hypothesis is that hunter-gatherer people became significantly fatter during periods of plenty. Again, there is little or no evidence that hunter-gatherers traditionally deposited large fat stores when food was readily available.<\/p>\n<p>Some geneticists have searched directly for so-called thrifty genes. Studies have revealed many genes with small effects associated with obesity or diabetes. However, these genes can explain only a few percentage points of the total population variation in obesity or diabetes.<\/p>\n<h2>The Drifty Gene and Other Hypotheses<\/h2>\n<p>Given the lack of evidence for the thrifty gene hypothesis, several researchers have suggested alternative hypotheses to explain population variation in obesity and diabetes. One hypothesis posits that susceptibility to obesity and diabetes may be a side effect of heat <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3771\">adaptation<\/a>. According to this idea, some populations evolved lower metabolic rates as an adaptation to heat stress, because lower metabolic rates reduced the amount of heat that the body produced. The lower metabolic rates also predisposed people to gain excess weight and develop obesity and diabetes.<\/p>\n<p>A thrifty phenotype hypothesis has also been proposed. This hypothesis suggests that individuals who have inadequate nutrition during fetal development might develop an insulin-resistant phenotype. The insulin-resistant phenotype would supposedly prepare these individuals for a life of famine, based on the environment within the womb. In a famine-free environment, however, the thrifty phenotype would lead to the development of diabetes.<\/p>\n<p>The most recent alternative to the thrifty gene hypothesis is the drifty gene hypothesis, which was proposed by biologist <a href=\"https:\/\/en.wikipedia.org\/wiki\/John_Speakman\">John Speakman<\/a>. He argues that genes protecting humans from obesity were under strong natural selection pressure for a very long period of time while human ancestors were subject to the risk of predation. According to this view, being able to outrun predators would have been an important factor selecting against fatness. When the risk of predation was lessened \u2014 perhaps as early as two million years ago \u2014 genes keeping fatness in check would no longer be selected for. Without selective pressure for these genes, their frequencies could change randomly due to genetic drift. In some populations, by chance, frequencies of the genes could decrease to relatively low levels, whereas in other populations the frequencies could be much higher.<\/p>\n<div>\n<h1>Feature: Myth vs. Reality<\/h1>\n<\/div>\n<figure id=\"attachment_2772\" aria-describedby=\"caption-attachment-2772\" style=\"width: 267px\" class=\"wp-caption alignright\"><img class=\"wp-image-2772\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Milk-Photo-by-Eiliv-Sonas-Aceron-on-Unsplash-scaled-2.jpg\" alt=\"\" width=\"267\" height=\"400\"><figcaption id=\"caption-attachment-2772\" class=\"wp-caption-text\"><em>Figure 6.8.6 Even if you are lactose intolerant, you may be able to drink milk or consume other dairy products without suffering adverse physical symptoms.<\/em><\/figcaption><\/figure>\n<p><strong>Myth:<\/strong>\u00a0Lactose intolerance is an allergy to milk.<\/p>\n<p><strong>Reality:<\/strong> Lactose intolerance is not an allergy because it is not an immune system response.\u00a0It is a sensitivity to milk caused by lactase deficiency so the sugar in milk cannot be digested. Milk allergy does exist, but it is a different condition that occurs in only about four per cent of people. It results when milk proteins (not milk sugar) trigger an immune reaction. How can you determine whether you have lactose intolerance or milk allergy? If you can drink lactose-free milk without symptoms, it is likely that you are lactose intolerant and not allergic to milk. However, if lactose-free milk also produces symptoms, it is likely that you have milk allergy. Note that it is possible to have both conditions.<\/p>\n<p><strong>Myth:<\/strong>\u00a0If you are lactose intolerant, you will never be able to drink milk or consume other dairy products without suffering adverse physical symptoms.<\/p>\n<p><strong>Reality:<\/strong>\u00a0Lactose intolerance does not mean that consuming milk and other dairy products is out of the question. Besides lactose-free milk, which is widely available, many dairy products have relatively low levels of lactose, so you may be able to consume at least small amounts of them without discomfort.\u00a0You may be able to consume milk in the form of yogurt without any problems because the bacteria in yogurt produce lactase that breaks down the lactose. Greek yogurt may be your best bet, because it is lower in lactose to begin with. Aged cheeses also tend to have relatively low levels of lactose, because of the cheese-making process. Finally, by gradually adding milk or milk products to your diet, you may be able to increase your tolerance to lactose.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.8 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Milk contains the sugar lactose, a disaccharide. Lactose must be broken down into its two component sugars to be absorbed by the small intestine, and the enzyme lactase is needed for this process.<\/li>\n<li>In about 60 per cent of people worldwide, the ability to synthesize lactase and digest lactose declines after the first two years of life. These people become lactose intolerant and cannot consume much milk without suffering symptoms of bloating, cramps, and diarrhea.<\/li>\n<li>In populations that herded milking animals for thousands of years, lactase persistence evolved. People who were able to synthesize lactase and digest lactose throughout life were strongly favored by natural selection. People \u2014 including\u00a0many Europeans and European-Americans \u2014\u00a0who descended from these early herders generally still have lactase persistence.<\/li>\n<li>Human populations may vary in how efficiently they use calories in food. Some people (especially South Pacific Islanders, Native Americans, and sub-Saharan Africans) seem to be able to get by on fewer calories than would be adequate for others, so they tend to easily gain weight, become obese, and develop diseases such as diabetes.<\/li>\n<li>The thrifty gene hypothesis answers the question of how genes for this ability could have evolved. It proposes that \u201cthrifty genes\u201d were selected for because they allowed people to use calories efficiently and store body fat when food was plentiful so they had a reserve to use when food was scarce. Thrifty genes become detrimental and lead to obesity and diabetes when food is consistently plentiful.<\/li>\n<li>Several assumptions underlying the thrifty gene hypothesis have been called into question, and genetic research has been unable to actually identify thrifty genes. Alternate hypotheses to the thrifty gene hypothesis have been proposed, including the drifty gene hypothesis. The latter hypothesis explains variation in the tendency to become obese by genetic drift on neutral genes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.8 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-93\">\n<div class=\"h5p-content\" data-content-id=\"93\"><\/div>\n<\/div>\n<\/li>\n<li>Distinguish between the terms lactose and lactase.<\/li>\n<li>What is lactose intolerance, and what percentage of all people have it?<\/li>\n<li>Where and why did lactase persistence evolve?<\/li>\n<li>What is the thrifty gene hypothesis?<\/li>\n<li>How well is the thrifty gene hypothesis supported by evidence?<\/li>\n<li>Describe an alternative hypothesis to the thrifty gene hypothesis.<\/li>\n<li>Do you think that a lack of exposure to dairy products might affect a person\u2019s lactase level? Why or why not?<\/li>\n<li>Describe an experiment you would want to do or data you would want to analyze that would help to test the thrifty phenotype hypothesis. Remember, you are studying people, so be sure it is ethical! Discuss possible confounding factors that you should control for, or that might affect the interpretation of your results.<\/li>\n<li>Explain the relationship between insulin, blood glucose, and type II diabetes.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.8 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=G1NGzycaQV0&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Why Are People Lactose Intolerant?, Super Scienced, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=UMhLBPPtlrY<\/p>\n<p style=\"text-align: center\">Peter Attia: What if we're wrong about diabetes?, TED, 2013.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=4O8k9qe8fjI<\/p>\n<p style=\"text-align: center\">The Last Nomadic Reindeer Herders in the World, Great Big Story, 2018.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=XIYag5MWhPU<\/p>\n<p style=\"text-align: center\">Experience a Traditional Whale Hunt in Northern Alaska | Short Film Showcase, National Geographic, 2018.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 6.8.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/cedarsummitfarm\/7481908244\">IMG_4325 Milk Mustache licking 3<\/a> by <a class=\"owner-name truncate\" title=\"Go to Cedar Summit Farm's photostream\" href=\"https:\/\/www.flickr.com\/photos\/cedarsummitfarm\/\" data-track=\"attributionNameClick\">Cedar Summit Farm<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\">CC BY SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 6.8.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Lactose_Haworth.svg\">Lactose Haworth<\/a> by <a title=\"User:NEUROtiker\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:NEUROtiker\">NEUROtiker<\/a> on Wikimedia Commons is in the\u00a0<a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong style=\"text-align: initial;font-size: 1em\">Figure 6.8.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Lactase.png\" rel=\"cc:attributionURL\">Lactase<\/a> by <a class=\"mw-redirect\" title=\"User:Boghog2\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Boghog2\">Boghog2<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain <\/a>(https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 6.8.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Laktoseintoleranz-1.svg\" rel=\"cc:attributionURL\">Lactose Intolerance<\/a> by <a class=\"extiw\" title=\"de:Benutzer:Rainer Zenz\" href=\"https:\/\/de.wikipedia.org\/wiki\/Benutzer:Rainer_Zenz\">Rainer Z<\/a>\u00a0<a class=\"extiw\" title=\"de:Benutzer Diskussion:Rainer Zenz\" href=\"https:\/\/de.wikipedia.org\/wiki\/Benutzer_Diskussion:Rainer_Zenz\">...<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 6.8.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Reindeer_herding.jpg\" rel=\"cc:attributionURL\">Reindeer_herding<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/photos\/51496968@N00\" rel=\"nofollow\">Mats Andersson<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en) license.<\/p>\n<p><strong>Figure 6.8.6<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/_8bnn1GqX70\" rel=\"cc:attributionURL\">Milk Photo<\/a> [photo] by <span class=\"_1JARO\"><a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@shootdelicious\">Eiliv-Sonas Aceron<\/a> <\/span>on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Great Big Story. (2018, November 29). The last nomadic reindeer herders in the world. YouTube. https:\/\/www.youtube.com\/watch?v=4O8k9qe8fjI&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Super Scienced. (2016, February 26). Why are people lactose intolerant? YouTube. https:\/\/www.youtube.com\/watch?v=G1NGzycaQV0&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">National Geographic. (2018, November 27). Experience a traditional whale hunt in northern Alaska | Short film showcase. YouTube. https:\/\/www.youtube.com\/watch?v=XIYag5MWhPU&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED. (2013, June 25). Peter Attia: What if we're wrong about diabetes? YouTube. https:\/\/www.youtube.com\/watch?v=UMhLBPPtlrY&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2019, December 15). James V. Neel. In\u00a0<i>Wikipedia. <\/i>https:\/\/en.wikipedia.org\/w\/index.php?title=James_V._Neel&amp;oldid=930860629<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 9). John Speakman. In\u00a0<i>Wikipedia. <\/i>https:\/\/en.wikipedia.org\/w\/index.php?title=John_Speakman&amp;oldid=961610417<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4935_3963\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4935_3963\"><div tabindex=\"-1\"><p>Created by CK-12\/Adapted by Christine Miller<\/p>\n<h1>Case Study: Diet Dilemma<\/h1>\n<figure id=\"attachment_248\" aria-describedby=\"caption-attachment-248\" style=\"width: 300px\" class=\"wp-caption alignright\"><img class=\"size-medium wp-image-248\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/diabetes-528678_1920-1.jpg\" alt=\"Image shows equipment related to treatment of diabetes. Blood sugar monitor, insulin, hypodermic needle, and a prescription bottle.\" width=\"300\" height=\"200\"><figcaption id=\"caption-attachment-248\" class=\"wp-caption-text\"><em>Figure 3.1.1 Diabetes requires careful monitoring and adjustment of blood sugar.<\/em><\/figcaption><\/figure>\n<p>Joseph is a college student who has watched his father suffer from complications of <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/type-2-diabetes\/symptoms-causes\/syc-20351193\" target=\"_blank\" rel=\"noopener noreferrer\">type 2 diabetes<\/a> for the past few years. For people with type 2 diabetes, the hormone insulin does not transmit its signal sufficiently. Insulin normally removes sugar from the bloodstream and brings it into the body\u2019s cells. Diabetes prevents blood sugar levels from being properly regulated, and this can cause damage to the cells.<\/p>\n<p>Diabetes can be treated with insulin injections, as shown above, as well as with dietary modifications, but complications can still occur. Joseph\u2019s father has some nerve damage (or <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/peripheral-neuropathy\/symptoms-causes\/syc-20352061\" target=\"_blank\" rel=\"noopener noreferrer\">neuropathy<\/a>) in his feet which makes his feet numb. He didn\u2019t notice when he developed minor injuries to his feet which caused some serious infections.<\/p>\n<figure id=\"attachment_249\" aria-describedby=\"caption-attachment-249\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img class=\"size-medium wp-image-249\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/luke-pamer-40086-unsplash-2-1.jpg\" alt=\"A healthy diet and exercise can prevent Type 2 Diabetes. Image shows a man with a backpack on a hike.\" width=\"300\" height=\"200\"><figcaption id=\"caption-attachment-249\" class=\"wp-caption-text\"><em>Figure 3.1.2 A healthy diet and exercise can prevent Type 2 Diabetes.<\/em><\/figcaption><\/figure>\n<p>Joseph is obese and knows that his weight \u2014 along with a family history of diabetes \u2014 increases his risk of getting the disease himself. He wants to avoid the health issues that his father suffered, so he begins walking every day for exercise and starts to lose\u00a0 weight. Joseph also wants to improve his diet in order to lose <em>more<\/em>\u00a0weight, lower his risk of diabetes, and improve his general health, but he is overwhelmed with all of the different dietary advice he reads online and hears from his friends and family.<\/p>\n<p>Joseph\u2019s father tells him to limit refined carbohydrates, such as white bread and rice, because that is what\u00a0<em>he\u00a0<\/em>does to help keep his blood sugar at an acceptable level, but Joseph\u2019s friend tells him that eating a diet high in carbohydrates and low in fat is a good way to lose weight. Joseph reads online that \u201ceating clean\u201d by eating whole, unprocessed foods and avoiding food with \u201cchemicals\u201d can help with weight loss. One piece of advice that <em>everyone<\/em>\u00a0seems to agree on is that drinking enough water is good for overall health.<\/p>\n<p>All this dietary advice may sound confusing, but you can better understand health conditions, such as diabetes, and the role of diet and nutrition by understanding chemistry. Chemistry is much more than chemical reactions in test tubes in a lab \u2014 it is the atoms, molecules, and reactions that make us who we are and keep us alive and functioning properly. Our diets are one of the main ways our bodies take in raw materials that are needed for the important chemical reactions that take place inside of us.<\/p>\n<div>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1><span style=\"color: #ffffff\">Chapter Overview: Chemistry\u00a0<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>As you read this chapter, you will learn more about how chemistry relates to our lives, health, and the foods we eat. Specifically, you will learn about:<\/p>\n<ul>\n<li>The nature of chemical substances, including elements, compounds, and their component <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_3619\"><strong>atoms<\/strong> <\/a>and molecules.<\/li>\n<li>The structures and functions of biochemical compounds, including carbohydrates, lipids, proteins, and nucleic acids (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4935_277\"><strong>DNA<\/strong><\/a> and RNA).<\/li>\n<li>What chemical reactions are, how energy is involved in chemical reactions, how enzymes assist in chemical reactions, and some types of biochemical reactions in living organisms.<\/li>\n<li>Properties of water and the importance of water for most biochemical processes.<\/li>\n<li>What pH is, and why maintaining a proper pH in the body is important for biochemical reactions.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"textbox shaded\">\n<p>As you read the chapter, think about the following questions\u00a0regarding\u00a0Joseph\u2019s situation, as well as how diabetes and diet relate to the chemistry of life:<\/p>\n<ol>\n<li>Why do you think Joseph\u2019s father's diabetes increases Joseph's\u00a0risk of getting diabetes?<\/li>\n<li>What is the difference between refined (simple) carbohydrates and complex carbohydrates? Why are refined carbohydrates particularly problematic for people with diabetes?<\/li>\n<li>Insulin is a peptide hormone. In which class of biochemical compounds would you categorize insulin?<\/li>\n<li>Why is drinking enough water important for overall health? Can you drink too much water?<\/li>\n<li>Sometimes \u201ceating clean\u201d is described as avoiding \u201cchemicals\u201d in food. Think about the definition of \u201cchemicals\u201d and how it relates to what we eat.<\/li>\n<\/ol>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 3.1.1<\/strong><\/p>\n<p><a href=\"https:\/\/pixabay.com\/photos\/diabetes-blood-sugar-diabetic-528678\/\" rel=\"cc:attributionURL\">Diabetes-equipment<\/a> by\u00a0<a href=\"https:\/\/pixabay.com\/users\/stevepb-282134\/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=528678\" rel=\"dc:creator\">Steve Buissinne [stevepb]<\/a> on <a href=\"https:\/\/pixabay.com\/\">Pixabay<\/a>\u00a0is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/de\/service\/license\/).<\/p>\n<p><strong>Figure 3.1.2<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/8QYY0M-wTmE\" rel=\"cc:attributionURL\">Early Morning Hike,<\/a> by<a href=\"https:\/\/unsplash.com\/@luke_pamer\" rel=\"dc:creator\">\u00a0Luke Pamer<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash,<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash license<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Peripheral neuropathy [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/peripheral-neuropathy\/symptoms-causes\/syc-20352061<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Type 2 diabetes [online article]. 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