{"id":4893,"date":"2019-06-24T15:15:23","date_gmt":"2019-06-24T15:15:23","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/12-6-nails-3\/"},"modified":"2023-11-30T18:55:23","modified_gmt":"2023-11-30T18:55:23","slug":"12-6-nails-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/12-6-nails-3\/","title":{"raw":"10.6\u00a0Nails","rendered":"10.6\u00a0Nails"},"content":{"raw":"&nbsp;\r\n\r\n[caption id=\"attachment_3911\" align=\"aligncenter\" width=\"400\"]<img class=\"wp-image-3911\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Nails-by-allison-christine-vPrqHSLdF28-unsplash-scaled-e1591304396521-2.jpg\" alt=\"10.6.1\" width=\"400\" height=\"400\" \/> <em>Figure 10.6.1 Neat nails!<\/em>[\/caption]\r\n\r\n<div>\r\n<h1>Nail Art<\/h1>\r\n<\/div>\r\nPainting nails with coloured polish for aesthetic reasons is nothing new. In fact, there is evidence of this practice dating back to at least 3000 BCE. Today, painting and otherwise decorating the nails is big business, with annual revenues in the billions of dollars in North America alone! With all the attention (and money) given to nails as decorative objects, it\u2019s easy to forget that they also have important biological functions.\r\n<div>\r\n<h1>What Are Nails?<\/h1>\r\n<\/div>\r\n<strong>[pb_glossary id=\"5495\"]Nail<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\">[\/pb_glossary]<\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0are accessory organs of the [pb_glossary id=\"3521\"]skin[\/pb_glossary]. They are made of sheets of dead [pb_glossary id=\"3524\"]keratinocytes[\/pb_glossary] and are found on the far (or distal) ends of the fingers and toes. The keratin in nails makes them hard, but flexible. Nails serve a number of purposes, including protecting the digits, enhancing sensations, and acting as tools.<\/span>\r\n<div>\r\n<h1>Nail Anatomy<\/h1>\r\n<\/div>\r\n\r\n[caption id=\"attachment_3918\" align=\"alignright\" width=\"300\"]<img class=\" wp-image-3918\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0406_FingerNailAnatomy-2.png\" alt=\"10.5 Nail Anatomy\" width=\"300\" height=\"600\" \/> <em>Figure 10.6.2 The top diagram in this diagram shows the external, visible part of the nail and the cuticle. The bottom diagram shows internal structures in a cross-section of the nail and nail bed.<\/em>[\/caption]\r\n\r\nA nail has three main parts: the root, plate, and free margin. Other structures around or under the nail include the nail bed, cuticle, and nail fold. These structures are shown in Figure 10.6.2.\r\n<ul>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3912\"]nail root[\/pb_glossary]<\/strong>\u00a0is the portion of the nail found under the surface of the skin at the near (or proximal) end of the nail. It is where the nail begins.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"5613\"]nail plate[\/pb_glossary]<\/strong>\u00a0(or body) is the portion of the nail that is external to the skin. It is the visible part of the nail.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3916\"]free margin[\/pb_glossary]<\/strong>\u00a0is the portion of the nail that protrudes beyond the distal end of the finger or toe. This is the part that is cut or filed to keep the nail trimmed.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3914\"]nail bed[\/pb_glossary]<\/strong> is the area of skin under the nail plate. It is pink in\u00a0colour, due to the presence of capillaries in the\u00a0dermis.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3917\"]cuticle[\/pb_glossary]<\/strong>\u00a0is a layer of dead epithelial\u00a0cells\u00a0that overlaps and covers the edge of the nail plate. It helps to seal the edges of the nail to prevent infection of the underlying tissues.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3915\"]nail fold[\/pb_glossary]<\/strong>\u00a0is a groove in the skin in which the side edges of the nail plate are embedded.<\/li>\r\n<\/ul>\r\n<div>\r\n\r\n&nbsp;\r\n\r\n<\/div>\r\n<div>\r\n<h1>Nail Growth<\/h1>\r\n<\/div>\r\nNails grow from a deep layer of living epidermal tissue, known as the\u00a0<strong>[pb_glossary id=\"3920\"]nail matrix[\/pb_glossary],<\/strong> at the proximal end of the nail (see the bottom of the diagram in Figure 10.6.2). The nail matrix surrounds the nail root. It contains stem cells that divide to form keratinocytes, which are cells that produce keratin and make up the nail.\r\n<h2>Formation of the Nail Root and Nail Plate<\/h2>\r\nThe [pb_glossary id=\"3524\"]keratinocytes[\/pb_glossary] produced by the nail matrix accumulate to form tough, hard, translucent sheets of dead\u00a0cells\u00a0filled with [pb_glossary id=\"3525\"]keratin[\/pb_glossary]. The sheets make up the nail root, which slowly grows out of the skin and becomes the nail plate when it reaches the skin surface. As the nail grows longer, the cells of the nail root and nail plate are pushed toward the distal end of the finger or toe by new cells being formed in the nail matrix. The upper epidermal cells of the nail bed also move along with the nail plate as it grows toward the tip of the digit.\r\n\r\nThe proximal end of the nail plate near the root has a whitish crescent shape called the\u00a0<strong>[pb_glossary id=\"3921\"]lunula[\/pb_glossary]<\/strong>. This is where a small amount of the nail matrix is visible through the nail plate. The lunula is most pronounced in the nails of the thumbs, and may not be visible in the nails of the little fingers.\r\n<h2>Rate of Nail Growth<\/h2>\r\nNails grow at an average rate of 3 mm a month. Fingernails, however, grow up to four times as fast as toenails. If a fingernail is lost, it takes between three and six months to regrow completely, whereas a toenail takes between 12 and 18 months to regrow. The actual rate of growth of an individual\u2019s nails depends on many factors, including age, sex, season, diet, exercise level, and genes. If protected from breaking, nails can sometimes grow to be very long. The Chinese doctor in the photo below (Figure 10.6.3) has very long nails on two fingers of his left hand. This picture was taken in 1920 in China, where having long nails was a sign of aristocracy since it implied that one was wealthy enough to not have to do physical labour.\r\n\r\n[caption id=\"attachment_3922\" align=\"aligncenter\" width=\"313\"]<img class=\"wp-image-3922\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Chinese_doctor_with_long_finger_nails_an_aristocrat_ca.1920_CHS-249-scaled-3.jpg\" alt=\"10.6 Fingernails and aristocracy\" width=\"313\" height=\"500\" \/> <em>Figure 10.6.3 Nails, like hair, can have sociocultural relevance, as the man in this photo illustrates. His long nails indicate his aristocratic heritage.<\/em>[\/caption]\r\n\r\n<div>\r\n<h1>Functions of Nails<\/h1>\r\n<\/div>\r\nBoth fingernails and toenails protect the soft tissues of the fingers and toes from injury. Fingernails also serve to enhance sensation and precise movements of the fingertips through the counter-pressure exerted on the pulp of the fingers by the nails. In addition, fingernails can function as several different types of tools. For example, they enable a fine precision grip like tweezers, and can also be used for cutting and scraping.\r\n<div>\r\n<h1>Nails and Health<\/h1>\r\n<\/div>\r\nHealthcare providers, particularly EMTs, often examine the fingernail beds as a quick and easy indicator of oxygen saturation of the blood, or the amount of blood reaching the extremities. If the nail beds are bluish or purple, it is generally a sign of low oxygen saturation. To see if blood flow to the extremities is adequate, a blanch test may be done. In this test, a fingernail is briefly depressed to turn the nail bed white by forcing the blood out of its capillaries. When the pressure is released, the pink colour of the nail bed should return within a second or two if there is normal blood flow. If the return to a pink colour is delayed, then it can be an indicator of low blood volume, due to dehydration or shock.\r\n\r\n[caption id=\"attachment_3923\" align=\"alignleft\" width=\"386\"]<img class=\" wp-image-3923\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Toenail-fungus-Nagelpilz-3-2.jpg\" alt=\"10.6 Toenail fungus\" width=\"386\" height=\"290\" \/> <em>Figure 10.6.4 Fungus infections of the toenails are common. They often look worse than they are. Generally, they are more unsightly than painful or dangerous.<\/em>[\/caption]\r\n\r\nHow the visible portion of the nails appears can be used as an indicator of recent health status. In fact, nails have been used as diagnostic tools for hundreds \u2014 if not thousands \u2014 of years. Nail abnormalities, such as deep grooves, brittleness, discolouration, or unusually thin or thick nails, may indicate various illnesses, nutrient deficiencies, drug reactions, or other health problems.\r\n\r\nNails \u2014 especially toenails \u2014 are common sites of fungal infections (shown in Figure 10.6.4), causing nails to become thickened and yellowish in colour. Toenails are more often infected than fingernails because they are often confined in shoes, which creates a dark, warm, moist environment where fungi can thrive. Toes also tend to have less blood flow than fingers, making it harder for the immune system to detect and stop infections in toenails.\r\n\r\nAlthough nails are harder and tougher than skin, they are also more permeable. Harmful substances may be absorbed through the nails and cause health problems. Some of the substances that can pass through the nails include the herbicide Paraquat, fungicidal agents such as miconazole (e.g., Monistat), and sodium hypochlorite, which is an ingredient in common household bleach. Care should be taken to protect the nails from such substances when handling or immersing the hands in them by wearing latex or rubber gloves.\r\n<div>\r\n<h1>Feature: Reliable Sources<\/h1>\r\n[caption id=\"attachment_3924\" align=\"alignright\" width=\"400\"]<img class=\"wp-image-3924 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Pedicure-in-progress-from-wikimedia-commons-2.jpg\" alt=\"10.6.5 Nail salon\" width=\"400\" height=\"300\" \/> <em>Figure 10.6.5 Nail salons must follow very strict cleanliness guidelines in order to reduce the chances of transmitting pathogens from one customer to the next.<\/em>[\/caption]\r\n\r\n<\/div>\r\nDo you get regular manicures or pedicures from a nail technician? If so, there is a chance that you are putting your health at risk. Nail tools that are not properly disinfected between clients may transmit infections from one person to another. Cutting the cuticles with scissors may create breaks in the skin that let infective agents enter the body. Products such as acrylics, adhesives, and UV gels that are applied to the nails may be harmful, especially if they penetrate the nails and enter the skin.\r\n\r\nUse the Internet to find several reliable sources that address the health risks of professional manicures or pedicures. Try to find answers to the following questions:\r\n<ol>\r\n \t<li>What training and certification are required for professional nail technicians?<\/li>\r\n \t<li>What licenses and inspections are required for nail salons?<\/li>\r\n \t<li>What hygienic practices should be followed in nail salons to reduce the risk of infections being transmitted to clients?<\/li>\r\n \t<li>Which professional nail products are potentially harmful to the\u00a0human body\u00a0and which are safer?<\/li>\r\n \t<li>How likely is it to have an adverse health consequence when you get a professional manicure or pedicure?<\/li>\r\n \t<li>What steps can you take to ensure that a professional manicure or pedicure is safe?<\/li>\r\n<\/ol>\r\n<div>\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.6 Summary<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul>\r\n \t<li>[pb_glossary id=\"5495\"]Nails[\/pb_glossary]\u00a0are accessory organs of the [pb_glossary id=\"3521\"]skin[\/pb_glossary], consisting of sheets of dead, keratin-filled [pb_glossary id=\"3524\"]keratinocytes[\/pb_glossary]. The keratin in nails makes them hard, but flexible.<\/li>\r\n \t<li>A nail has three main parts: the [pb_glossary id=\"3912\"]nail root[\/pb_glossary] (which is under the epidermis), the [pb_glossary id=\"5613\"]nail plate[\/pb_glossary] (which is the visible part of the nail), and the [pb_glossary id=\"3916\"]free margin[\/pb_glossary] (which is the distal edge of the nail). Other structures under or around a nail include the [pb_glossary id=\"3914\"]nail bed[\/pb_glossary], [pb_glossary id=\"3917\"]cuticle[\/pb_glossary], and [pb_glossary id=\"3915\"]nail fold[\/pb_glossary].<\/li>\r\n \t<li>A nail grows from a deep layer of living epidermal tissues \u2014 called the [pb_glossary id=\"3920\"]nail matrix[\/pb_glossary] \u2014 at the proximal end of the nail. Stem cells in the nail matrix keep dividing to allow nail growth, forming first the nail root and then the nail plate as the nail continues to grow longer and emerges from the\u00a0epidermis.<\/li>\r\n \t<li>Fingernails grow faster than toenails. Actual rates of growth depend on many factors, such as age, sex, and season.<\/li>\r\n \t<li>Functions of nails include protecting the digits, enhancing sensations and precise movements of the fingertips, and acting as tools.<\/li>\r\n \t<li>The colour of the nail bed can be used to quickly assess oxygen and blood flow in a patient. How the nail plate grows out can reflect recent health problems, such as illness or nutrient deficiency.<\/li>\r\n \t<li>Nails \u2014 and especially toenails \u2014 are prone to fungus infections. Nails are more permeable than skin and can absorb several harmful substances, such as herbicides.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.6 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ol>\r\n \t<li>What are nails?<\/li>\r\n \t<li>[h5p id=\"588\"]<\/li>\r\n \t<li>Explain why most of the nail plate looks pink.<\/li>\r\n \t<li>Describe a lunula.<\/li>\r\n \t<li>Explain how a nail grows.<\/li>\r\n \t<li>Identify three functions of nails.<\/li>\r\n \t<li>Give several examples of how nails are related to health.<\/li>\r\n \t<li>What is the cuticle of the nail composed of?\u00a0What is the function of the cuticle?\u00a0Why is it a bad idea to cut the cuticle during a manicure?<\/li>\r\n \t<li>Is the nail plate composed of living or dead cells?<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.6 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=G35kPhbUZdg\r\n<p style=\"text-align: center;\">Longest Fingernails - Guinness World Records 60th Anniversary,\r\nGuinness World Records, 2014.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=aTSVHwzkYI4&amp;feature=emb_logo\r\n<p style=\"text-align: center;\">5 Things Your Nails Can Say About Your Health, SciShow, 2015.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=7w2gCBL1MCg\r\n<p style=\"text-align: center;\">Claws vs. Nails - Matthew Borths, TED-Ed, 2019.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n&nbsp;\r\n\r\n<\/div>\r\n<h2>Attributions<\/h2>\r\n<strong>Figure 10.6.1<\/strong>\r\n\r\n<a href=\"https:\/\/unsplash.com\/photos\/vPrqHSLdF28\" rel=\"cc:attributionURL\">Nails by allison-christine-vPrqHSLdF28<\/a>\u00a0[photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@happpyal\">allison christine<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).\r\n\r\n<strong>Figure 10.6.2<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0406_FingerNailAnatomy.png\" rel=\"cc:attributionURL\">Blausen_0406_FingerNailAnatomy<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a>\u00a0 on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\r\n\r\n<strong>Figure 10.6.3<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Chinese_doctor_with_long_finger_nails_(an_aristocrat),_ca.1920_(CHS-249).jpg\" rel=\"cc:attributionURL\">Chinese_doctor_with_long_finger_nails_(an_aristocrat),_ca.1920_(CHS-249)<\/a> by Pierce, C.C. (Charles C.), 1861-1946 from the <a href=\"http:\/\/digitallibrary.usc.edu\/cdm\/ref\/collection\/p15799coll65\/id\/8203\">USC Digital Library<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).\r\n\r\n<strong>Figure 10.6.4<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Nagelpilz-3.jpg\" rel=\"cc:attributionURL\">Toenail fungus Nagelpilz-3<\/a> by <a class=\"new mw-userlink\" title=\"User:Pepsyrock (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Pepsyrock&amp;action=edit&amp;redlink=1\">Pepsyrock<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).\r\n\r\n<strong>Figure 10.6.5<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Pedicure_1.jpg\" rel=\"cc:attributionURL\">OLYMPUS DIGITAL CAMERA<\/a> by <a class=\"extiw\" title=\"en:User:Stoive\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Stoive\">Stoive<\/a> at the English language Wikipedia, on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\" rel=\"license\">CC BY-SA 3.0 <\/a>(http:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/) license.\r\n\r\n<span style=\"font-size: 1.424em; font-weight: bold;\">\r\nReferences<\/span>\r\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\r\n<p class=\"hanging-indent\">Guiness World Records. (2014, December 8). Longest fingernails - Guinness World Records 60th Anniversary. YouTube. https:\/\/www.youtube.com\/watch?v=G35kPhbUZdg<\/p>\r\n<p class=\"hanging-indent\">SciShow. (2015, September 14). 5 things your nails can say about your health. YouTube. https:\/\/www.youtube.com\/watch?v=aTSVHwzkYI4<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2019, October 29). Claws vs. nails - Matthew Borths. YouTube. https:\/\/www.youtube.com\/watch?v=7w2gCBL1MCg<\/p>","rendered":"<p>&nbsp;<\/p>\n<figure id=\"attachment_3911\" aria-describedby=\"caption-attachment-3911\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3911\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Nails-by-allison-christine-vPrqHSLdF28-unsplash-scaled-e1591304396521-2.jpg\" alt=\"10.6.1\" width=\"400\" height=\"400\" \/><figcaption id=\"caption-attachment-3911\" class=\"wp-caption-text\"><em>Figure 10.6.1 Neat nails!<\/em><\/figcaption><\/figure>\n<div>\n<h1>Nail Art<\/h1>\n<\/div>\n<p>Painting nails with coloured polish for aesthetic reasons is nothing new. In fact, there is evidence of this practice dating back to at least 3000 BCE. Today, painting and otherwise decorating the nails is big business, with annual revenues in the billions of dollars in North America alone! With all the attention (and money) given to nails as decorative objects, it\u2019s easy to forget that they also have important biological functions.<\/p>\n<div>\n<h1>What Are Nails?<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_5495\">Nail<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0are accessory organs of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3521\">skin<\/a>. They are made of sheets of dead <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3524\">keratinocytes<\/a> and are found on the far (or distal) ends of the fingers and toes. The keratin in nails makes them hard, but flexible. Nails serve a number of purposes, including protecting the digits, enhancing sensations, and acting as tools.<\/span><\/p>\n<div>\n<h1>Nail Anatomy<\/h1>\n<\/div>\n<figure id=\"attachment_3918\" aria-describedby=\"caption-attachment-3918\" style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3918\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0406_FingerNailAnatomy-2.png\" alt=\"10.5 Nail Anatomy\" width=\"300\" height=\"600\" \/><figcaption id=\"caption-attachment-3918\" class=\"wp-caption-text\"><em>Figure 10.6.2 The top diagram in this diagram shows the external, visible part of the nail and the cuticle. The bottom diagram shows internal structures in a cross-section of the nail and nail bed.<\/em><\/figcaption><\/figure>\n<p>A nail has three main parts: the root, plate, and free margin. Other structures around or under the nail include the nail bed, cuticle, and nail fold. These structures are shown in Figure 10.6.2.<\/p>\n<ul>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3912\">nail root<\/a><\/strong>\u00a0is the portion of the nail found under the surface of the skin at the near (or proximal) end of the nail. It is where the nail begins.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_5613\">nail plate<\/a><\/strong>\u00a0(or body) is the portion of the nail that is external to the skin. It is the visible part of the nail.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3916\">free margin<\/a><\/strong>\u00a0is the portion of the nail that protrudes beyond the distal end of the finger or toe. This is the part that is cut or filed to keep the nail trimmed.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3914\">nail bed<\/a><\/strong> is the area of skin under the nail plate. It is pink in\u00a0colour, due to the presence of capillaries in the\u00a0dermis.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3917\">cuticle<\/a><\/strong>\u00a0is a layer of dead epithelial\u00a0cells\u00a0that overlaps and covers the edge of the nail plate. It helps to seal the edges of the nail to prevent infection of the underlying tissues.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3915\">nail fold<\/a><\/strong>\u00a0is a groove in the skin in which the side edges of the nail plate are embedded.<\/li>\n<\/ul>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<div>\n<h1>Nail Growth<\/h1>\n<\/div>\n<p>Nails grow from a deep layer of living epidermal tissue, known as the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3920\">nail matrix<\/a>,<\/strong> at the proximal end of the nail (see the bottom of the diagram in Figure 10.6.2). The nail matrix surrounds the nail root. It contains stem cells that divide to form keratinocytes, which are cells that produce keratin and make up the nail.<\/p>\n<h2>Formation of the Nail Root and Nail Plate<\/h2>\n<p>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3524\">keratinocytes<\/a> produced by the nail matrix accumulate to form tough, hard, translucent sheets of dead\u00a0cells\u00a0filled with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3525\">keratin<\/a>. The sheets make up the nail root, which slowly grows out of the skin and becomes the nail plate when it reaches the skin surface. As the nail grows longer, the cells of the nail root and nail plate are pushed toward the distal end of the finger or toe by new cells being formed in the nail matrix. The upper epidermal cells of the nail bed also move along with the nail plate as it grows toward the tip of the digit.<\/p>\n<p>The proximal end of the nail plate near the root has a whitish crescent shape called the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3921\">lunula<\/a><\/strong>. This is where a small amount of the nail matrix is visible through the nail plate. The lunula is most pronounced in the nails of the thumbs, and may not be visible in the nails of the little fingers.<\/p>\n<h2>Rate of Nail Growth<\/h2>\n<p>Nails grow at an average rate of 3 mm a month. Fingernails, however, grow up to four times as fast as toenails. If a fingernail is lost, it takes between three and six months to regrow completely, whereas a toenail takes between 12 and 18 months to regrow. The actual rate of growth of an individual\u2019s nails depends on many factors, including age, sex, season, diet, exercise level, and genes. If protected from breaking, nails can sometimes grow to be very long. The Chinese doctor in the photo below (Figure 10.6.3) has very long nails on two fingers of his left hand. This picture was taken in 1920 in China, where having long nails was a sign of aristocracy since it implied that one was wealthy enough to not have to do physical labour.<\/p>\n<figure id=\"attachment_3922\" aria-describedby=\"caption-attachment-3922\" style=\"width: 313px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3922\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Chinese_doctor_with_long_finger_nails_an_aristocrat_ca.1920_CHS-249-scaled-3.jpg\" alt=\"10.6 Fingernails and aristocracy\" width=\"313\" height=\"500\" \/><figcaption id=\"caption-attachment-3922\" class=\"wp-caption-text\"><em>Figure 10.6.3 Nails, like hair, can have sociocultural relevance, as the man in this photo illustrates. His long nails indicate his aristocratic heritage.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Functions of Nails<\/h1>\n<\/div>\n<p>Both fingernails and toenails protect the soft tissues of the fingers and toes from injury. Fingernails also serve to enhance sensation and precise movements of the fingertips through the counter-pressure exerted on the pulp of the fingers by the nails. In addition, fingernails can function as several different types of tools. For example, they enable a fine precision grip like tweezers, and can also be used for cutting and scraping.<\/p>\n<div>\n<h1>Nails and Health<\/h1>\n<\/div>\n<p>Healthcare providers, particularly EMTs, often examine the fingernail beds as a quick and easy indicator of oxygen saturation of the blood, or the amount of blood reaching the extremities. If the nail beds are bluish or purple, it is generally a sign of low oxygen saturation. To see if blood flow to the extremities is adequate, a blanch test may be done. In this test, a fingernail is briefly depressed to turn the nail bed white by forcing the blood out of its capillaries. When the pressure is released, the pink colour of the nail bed should return within a second or two if there is normal blood flow. If the return to a pink colour is delayed, then it can be an indicator of low blood volume, due to dehydration or shock.<\/p>\n<figure id=\"attachment_3923\" aria-describedby=\"caption-attachment-3923\" style=\"width: 386px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3923\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Toenail-fungus-Nagelpilz-3-2.jpg\" alt=\"10.6 Toenail fungus\" width=\"386\" height=\"290\" \/><figcaption id=\"caption-attachment-3923\" class=\"wp-caption-text\"><em>Figure 10.6.4 Fungus infections of the toenails are common. They often look worse than they are. Generally, they are more unsightly than painful or dangerous.<\/em><\/figcaption><\/figure>\n<p>How the visible portion of the nails appears can be used as an indicator of recent health status. In fact, nails have been used as diagnostic tools for hundreds \u2014 if not thousands \u2014 of years. Nail abnormalities, such as deep grooves, brittleness, discolouration, or unusually thin or thick nails, may indicate various illnesses, nutrient deficiencies, drug reactions, or other health problems.<\/p>\n<p>Nails \u2014 especially toenails \u2014 are common sites of fungal infections (shown in Figure 10.6.4), causing nails to become thickened and yellowish in colour. Toenails are more often infected than fingernails because they are often confined in shoes, which creates a dark, warm, moist environment where fungi can thrive. Toes also tend to have less blood flow than fingers, making it harder for the immune system to detect and stop infections in toenails.<\/p>\n<p>Although nails are harder and tougher than skin, they are also more permeable. Harmful substances may be absorbed through the nails and cause health problems. Some of the substances that can pass through the nails include the herbicide Paraquat, fungicidal agents such as miconazole (e.g., Monistat), and sodium hypochlorite, which is an ingredient in common household bleach. Care should be taken to protect the nails from such substances when handling or immersing the hands in them by wearing latex or rubber gloves.<\/p>\n<div>\n<h1>Feature: Reliable Sources<\/h1>\n<figure id=\"attachment_3924\" aria-describedby=\"caption-attachment-3924\" style=\"width: 400px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3924 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Pedicure-in-progress-from-wikimedia-commons-2.jpg\" alt=\"10.6.5 Nail salon\" width=\"400\" height=\"300\" \/><figcaption id=\"caption-attachment-3924\" class=\"wp-caption-text\"><em>Figure 10.6.5 Nail salons must follow very strict cleanliness guidelines in order to reduce the chances of transmitting pathogens from one customer to the next.<\/em><\/figcaption><\/figure>\n<\/div>\n<p>Do you get regular manicures or pedicures from a nail technician? If so, there is a chance that you are putting your health at risk. Nail tools that are not properly disinfected between clients may transmit infections from one person to another. Cutting the cuticles with scissors may create breaks in the skin that let infective agents enter the body. Products such as acrylics, adhesives, and UV gels that are applied to the nails may be harmful, especially if they penetrate the nails and enter the skin.<\/p>\n<p>Use the Internet to find several reliable sources that address the health risks of professional manicures or pedicures. Try to find answers to the following questions:<\/p>\n<ol>\n<li>What training and certification are required for professional nail technicians?<\/li>\n<li>What licenses and inspections are required for nail salons?<\/li>\n<li>What hygienic practices should be followed in nail salons to reduce the risk of infections being transmitted to clients?<\/li>\n<li>Which professional nail products are potentially harmful to the\u00a0human body\u00a0and which are safer?<\/li>\n<li>How likely is it to have an adverse health consequence when you get a professional manicure or pedicure?<\/li>\n<li>What steps can you take to ensure that a professional manicure or pedicure is safe?<\/li>\n<\/ol>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.6 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_5495\">Nails<\/a>\u00a0are accessory organs of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3521\">skin<\/a>, consisting of sheets of dead, keratin-filled <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3524\">keratinocytes<\/a>. The keratin in nails makes them hard, but flexible.<\/li>\n<li>A nail has three main parts: the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3912\">nail root<\/a> (which is under the epidermis), the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_5613\">nail plate<\/a> (which is the visible part of the nail), and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3916\">free margin<\/a> (which is the distal edge of the nail). Other structures under or around a nail include the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3914\">nail bed<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3917\">cuticle<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3915\">nail fold<\/a>.<\/li>\n<li>A nail grows from a deep layer of living epidermal tissues \u2014 called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4893_3920\">nail matrix<\/a> \u2014 at the proximal end of the nail. Stem cells in the nail matrix keep dividing to allow nail growth, forming first the nail root and then the nail plate as the nail continues to grow longer and emerges from the\u00a0epidermis.<\/li>\n<li>Fingernails grow faster than toenails. Actual rates of growth depend on many factors, such as age, sex, and season.<\/li>\n<li>Functions of nails include protecting the digits, enhancing sensations and precise movements of the fingertips, and acting as tools.<\/li>\n<li>The colour of the nail bed can be used to quickly assess oxygen and blood flow in a patient. How the nail plate grows out can reflect recent health problems, such as illness or nutrient deficiency.<\/li>\n<li>Nails \u2014 and especially toenails \u2014 are prone to fungus infections. Nails are more permeable than skin and can absorb several harmful substances, such as herbicides.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.6 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What are nails?<\/li>\n<li>\n<div id=\"h5p-588\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-588\" class=\"h5p-iframe\" data-content-id=\"588\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"10.6 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Explain why most of the nail plate looks pink.<\/li>\n<li>Describe a lunula.<\/li>\n<li>Explain how a nail grows.<\/li>\n<li>Identify three functions of nails.<\/li>\n<li>Give several examples of how nails are related to health.<\/li>\n<li>What is the cuticle of the nail composed of?\u00a0What is the function of the cuticle?\u00a0Why is it a bad idea to cut the cuticle during a manicure?<\/li>\n<li>Is the nail plate composed of living or dead cells?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.6 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"Longest Fingernails - Guinness World Records 60th Anniversary\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/G35kPhbUZdg?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Longest Fingernails &#8211; Guinness World Records 60th Anniversary,<br \/>\nGuinness World Records, 2014.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"5 Health Truths Hidden in Your Fingernails\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/aTSVHwzkYI4?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">5 Things Your Nails Can Say About Your Health, SciShow, 2015.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-3\" title=\"Claws vs. nails - Matthew Borths\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/7w2gCBL1MCg?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Claws vs. Nails &#8211; Matthew Borths, TED-Ed, 2019.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 10.6.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/vPrqHSLdF28\" rel=\"cc:attributionURL\">Nails by allison-christine-vPrqHSLdF28<\/a>\u00a0[photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@happpyal\">allison christine<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 10.6.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0406_FingerNailAnatomy.png\" rel=\"cc:attributionURL\">Blausen_0406_FingerNailAnatomy<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a>\u00a0 on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 10.6.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Chinese_doctor_with_long_finger_nails_(an_aristocrat),_ca.1920_(CHS-249).jpg\" rel=\"cc:attributionURL\">Chinese_doctor_with_long_finger_nails_(an_aristocrat),_ca.1920_(CHS-249)<\/a> by Pierce, C.C. (Charles C.), 1861-1946 from the <a href=\"http:\/\/digitallibrary.usc.edu\/cdm\/ref\/collection\/p15799coll65\/id\/8203\">USC Digital Library<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/p>\n<p><strong>Figure 10.6.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Nagelpilz-3.jpg\" rel=\"cc:attributionURL\">Toenail fungus Nagelpilz-3<\/a> by <a class=\"new mw-userlink\" title=\"User:Pepsyrock (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Pepsyrock&amp;action=edit&amp;redlink=1\">Pepsyrock<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/p>\n<p><strong>Figure 10.6.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Pedicure_1.jpg\" rel=\"cc:attributionURL\">OLYMPUS DIGITAL CAMERA<\/a> by <a class=\"extiw\" title=\"en:User:Stoive\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Stoive\">Stoive<\/a> at the English language Wikipedia, on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\" rel=\"license\">CC BY-SA 3.0 <\/a>(http:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/) license.<\/p>\n<p><span style=\"font-size: 1.424em; font-weight: bold;\"><br \/>\nReferences<\/span><\/p>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">Guiness World Records. (2014, December 8). Longest fingernails &#8211; Guinness World Records 60th Anniversary. YouTube. https:\/\/www.youtube.com\/watch?v=G35kPhbUZdg<\/p>\n<p class=\"hanging-indent\">SciShow. (2015, September 14). 5 things your nails can say about your health. YouTube. https:\/\/www.youtube.com\/watch?v=aTSVHwzkYI4<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2019, October 29). Claws vs. nails &#8211; Matthew Borths. YouTube. https:\/\/www.youtube.com\/watch?v=7w2gCBL1MCg<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4893_5495\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_5495\"><div tabindex=\"-1\"><p>accessory organ of the skin made of sheets of dead keratinocytes at the distal ends of the fingers and toes<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3521\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3521\"><div tabindex=\"-1\"><p>visible part of a nail that is external to the skin<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3524\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3524\"><div tabindex=\"-1\"><p>Acquired Immunodeficiency Syndrome - a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV). By damaging your immune system, HIV interferes with your body's ability to fight infection and disease.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3912\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3912\"><div tabindex=\"-1\"><p>A metabolic process that produces chemical changes in organic substrates through the action of enzymes. In biochemistry, it is narrowly defined as the extraction of energy from carbohydrates in the absence of oxygen.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_5613\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_5613\"><div tabindex=\"-1\"><p>visible part of a nail that is external to the skin<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3916\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3916\"><div tabindex=\"-1\"><p>A loop system wherein the system responds to a perturbation. The response may be in the same direction (as in positive feedback) or in the opposite direction (as in negative feedback). A feedback mechanism may be observed at the level of cells, organisms, ecosystems, or the biosphere.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3914\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3914\"><div tabindex=\"-1\"><p>A three-dimensional network of extracellular macromolecules, such as collagen, enzymes, and glycoproteins, that provide structural and biochemical support to surrounding cells.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3917\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3917\"><div tabindex=\"-1\"><p>The fusion of haploid gametes, egg and sperm, to form the diploid zygote.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3915\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3915\"><div tabindex=\"-1\"><p>A loop system wherein the system responds to a perturbation. The response may be in the same direction (as in positive feedback) or in the opposite direction (as in negative feedback). A feedback mechanism may be observed at the level of cells, organisms, ecosystems, or the biosphere.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3920\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3920\"><div tabindex=\"-1\"><p>A cell in connective tissue which produces collagen and\/or other protein fibers.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3525\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3525\"><div tabindex=\"-1\"><p>Respiration using electron acceptors other than molecular oxygen. Although oxygen is not the final electron acceptor, the process still uses a respiratory electron transport chain.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4893_3921\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4893_3921\"><div tabindex=\"-1\"><p>An involuntary human body response mediated by the nervous and endocrine systems that prepares the body to fight or flee from perceived danger.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"author":32,"menu_order":6,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":"cc-by-nc"},"chapter-type":[48],"contributor":[],"license":[55],"class_list":["post-4893","chapter","type-chapter","status-publish","hentry","chapter-type-numberless","license-cc-by-nc"],"part":4853,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/users\/32"}],"version-history":[{"count":4,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4893\/revisions"}],"predecessor-version":[{"id":6455,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4893\/revisions\/6455"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/parts\/4853"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4893\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/media?parent=4893"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapter-type?post=4893"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/contributor?post=4893"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/license?post=4893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}