{"id":4877,"date":"2019-06-24T15:13:09","date_gmt":"2019-06-24T15:13:09","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/12-4-dermis-3\/"},"modified":"2023-11-30T18:54:58","modified_gmt":"2023-11-30T18:54:58","slug":"12-4-dermis-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/12-4-dermis-3\/","title":{"raw":"10.4\u00a0Dermis","rendered":"10.4\u00a0Dermis"},"content":{"raw":"&nbsp;\r\n<div>\r\n\r\n[caption id=\"attachment_3560\" align=\"aligncenter\" width=\"400\"]<img class=\"wp-image-3560\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Goose_bumps-2.jpg\" alt=\"10.4.1\" width=\"400\" height=\"209\" \/> <em>Figure 10.4.1 Goose bumps!<\/em>[\/caption]\r\n<h1>Goose Bumps<\/h1>\r\n<\/div>\r\nNo doubt you\u2019ve experienced the tiny, hair-raising skin bumps called goose bumps, like those you see in Figure 10.4.1. They happen when you feel chilly. Do you know what causes goose bumps, or why they pop up when you are cold? The answers to these questions involve the layer of skin known as the dermis.\r\n<div>\r\n<h1>What is the Dermis?<\/h1>\r\n<\/div>\r\nThe\u00a0<strong>[pb_glossary id=\"5967\"]dermis[\/pb_glossary]<\/strong>\u00a0is the inner of the two major layers that make up the skin, the outer layer being the\u00a0<strong>[pb_glossary id=\"5991\"]epidermis[\/pb_glossary]<\/strong>. The dermis consists mainly of [pb_glossary id=\"2815\"]connective tissues[\/pb_glossary]. It also contains most skin structures, such as [pb_glossary id=\"2936\"]glands[\/pb_glossary]\u00a0and\u00a0blood vessels. The dermis is anchored to the tissues below it by flexible collagen bundles that permit most areas of the skin to move freely over subcutaneous (\u201cbelow the skin\u201d) tissues. Functions of the dermis include cushioning subcutaneous tissues, regulating body\u00a0temperature, sensing\u00a0the environment, and excreting wastes.\r\n<div>\r\n<h1>Anatomy of the Dermis<\/h1>\r\n<\/div>\r\nThe basic anatomy of the dermis is a matrix, or sort of scaffolding, composed of connective tissues. These tissues include collagen fibres \u2014 which provide toughness \u2014 and elastin fibres, which provide elasticity. Surrounding these fibres, the matrix also includes a gel-like substance made of proteins. The tissues of the matrix give the dermis both strength and flexibility.\r\n\r\nThe dermis is divided into two layers: the papillary layer and the reticular layer. Both layers are shown in Figure 10.4.2 below and described in the text that follows.\r\n\r\n[caption id=\"attachment_3561\" align=\"aligncenter\" width=\"376\"]<img class=\" wp-image-3561\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Layers_of_the_Dermis-2.jpg\" alt=\"Layers of the Dermis\" width=\"376\" height=\"485\" \/> <em>Figure 10.4.2 This photomicrograph shows a cross-section of the papillary and reticular layers of the dermis.<\/em>[\/caption]\r\n<h2>Papillary Layer<\/h2>\r\nThe\u00a0<strong>[pb_glossary id=\"5843\"]papillary layer[\/pb_glossary]<\/strong> is the upper layer of the dermis, just below the [pb_glossary id=\"5907\"]basement membrane[\/pb_glossary] that connects the dermis to the epidermis above it. The papillary layer is the thinner of the two dermal layers. It is composed mainly of loosely arranged collagen fibres. The papillary layer is named for its fingerlike projections \u2014 or papillae \u2014 that extend upward into the epidermis. The papillae contain capillaries and sensory touch receptors.\r\n\r\n[caption id=\"attachment_3563\" align=\"alignleft\" width=\"390\"]<img class=\" wp-image-3563\" src=\"http:\/\/humanbiology.pressbooks.tru.ca\/wp-content\/uploads\/sites\/6\/2019\/06\/Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d_T\u0159eb\u00ed\u010d_District.jpg#fixme\" alt=\"10.3 Fingerprints\" width=\"390\" height=\"260\" \/> <em>Figure 10.4.3 This photo is an enlarged image of epidermal ridges on a finger.<\/em>[\/caption]\r\n\r\nThe papillae give the dermis a bumpy surface that interlocks with the epidermis above it, strengthening the connection between the two layers of skin. On the palms and soles, the papillae create epidermal ridges. Epidermal ridges on the fingers are commonly called fingerprints (see Figure 10.4.3). Fingerprints are genetically determined, so no two people (other than identical twins) have exactly the same fingerprint pattern. Therefore, fingerprints can be used as a means of identification, for example, at crime scenes. Fingerprints were much more commonly used forensically before DNA analysis was introduced for this purpose.\r\n<h2>Reticular Layer<\/h2>\r\nThe\u00a0[pb_glossary id=\"5847\"]<strong>reticular layer<\/strong> [\/pb_glossary]is the lower layer of the dermis, located below the papillary layer. It is the thicker of the two dermal layers. It is composed of densely woven collagen and elastin fibres. These protein fibres give the dermis its properties of strength and elasticity. This layer of the dermis cushions subcutaneous tissues of the body from stress and strain. The reticular layer of the dermis also contains most of the structures in the dermis, such as [pb_glossary id=\"2936\"]glands[\/pb_glossary] and hair [pb_glossary id=\"6015\"]follicle<span style=\"font-size: 1em;\">s<\/span><span style=\"text-align: initial; font-size: 1em;\">[\/pb_glossary]<\/span><span style=\"text-align: initial; font-size: 1em;\">.<\/span>\r\n<div>\r\n<h1>Structures in the Dermis<\/h1>\r\n<\/div>\r\nBoth papillary and reticular layers of the dermis contain numerous [pb_glossary id=\"3006\"]sensory receptors[\/pb_glossary], which make the skin the body\u2019s primary sensory organ for the sense of [pb_glossary id=\"3129\"]touch[\/pb_glossary]. Both dermal layers also contain blood vessels. They provide nutrients to remove wastes from dermal cells, as well as cells in the lowest layer of the epidermis, the [pb_glossary id=\"3542\"]stratum basale[\/pb_glossary]. The circulatory components of the dermis are shown in Figure 10.4.4 below.\r\n\r\n[caption id=\"attachment_3565\" align=\"aligncenter\" width=\"1024\"]<img class=\"size-full wp-image-3565\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0802_Skin_DermalCirculation-2.png\" alt=\"10.3 Dermal Circulation\" width=\"1024\" height=\"819\" \/> <em>Figure 10.4.4 Both the papillary layer and the reticular layer of the dermis contain blood vessels, as shown in this diagram.<\/em>[\/caption]\r\n<h2>Glands<\/h2>\r\nGlands in the reticular layer of the dermis include sweat glands and sebaceous (oil) glands. Both are exocrine glands, which are glands that release their secretions through ducts to nearby body surfaces. The diagram in Figure 10.4.5 shows these glands, as well as several other structures in the dermis.\r\n\r\n[caption id=\"attachment_3567\" align=\"aligncenter\" width=\"702\"]<img class=\"wp-image-3567 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anatomy_The_Skin_-_NCI_Visuals_Online-1-e1591224136617-2.jpg\" alt=\"10.4 Skin Glands\" width=\"702\" height=\"580\" \/> <em>Figure 10.4.5 The dermis contains sweat and oil (sebaceous) glands, as well as hair follicles and blood vessels.<\/em>[\/caption]\r\n<h3>Sweat Glands<\/h3>\r\n<strong>[pb_glossary id=\"3566\"]Sweat glands[\/pb_glossary]<\/strong>\u00a0produce the fluid called sweat, which contains mainly\u00a0water\u00a0and salts. The glands have ducts that carry the sweat to\u00a0hair\u00a0follicles, or to the surface of the skin. There are two different types of sweat glands: eccrine glands and apocrine glands.\r\n<ul>\r\n \t<li><strong>[pb_glossary id=\"3568\"]Eccrine sweat gland<strong>s<\/strong>[\/pb_glossary]<\/strong>\u00a0occur in skin all over the body. Their ducts empty through tiny openings called pores onto the skin surface. These sweat glands are involved in\u00a0temperature\u00a0regulation.<\/li>\r\n \t<li><strong>[pb_glossary id=\"3569\"]Apocrine sweat gland<strong>s<\/strong>[\/pb_glossary]<\/strong>\u00a0are larger than eccrine glands, and occur only in the skin of the armpits and groin. The ducts of apocrine glands empty into hair follicles, and then the sweat travels along hairs to reach the surface. Apocrine glands are inactive until\u00a0puberty, at which point they start producing an oily sweat that is consumed by\u00a0bacteria\u00a0living on the skin. The digestion of apocrine sweat by bacteria\u00a0causes\u00a0body odor.<\/li>\r\n<\/ul>\r\n<h3>Sebaceous Glands<\/h3>\r\n<strong>[pb_glossary id=\"3570\"]Sebaceous gland<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\">[\/pb_glossary]<\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0are exocrine glands that produce a thick, fatty substance called sebum.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\">[pb_glossary id=\"3571\"]Sebum[\/pb_glossary]<\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0is secreted into hair follicles and makes its way to the skin surface along hairs. It waterproofs the hair and skin, and helps prevent them from drying out. Sebum also has antibacterial properties, so it inhibits the growth of microorganisms on the skin. Sebaceous glands are found in every part of the skin \u2014 except for the palms of the hands and soles of the feet, where hair does not grow.<\/span>\r\n<h2>Hair Follicles<\/h2>\r\n<strong>[pb_glossary id=\"3572\"]Hair follicle<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\">[\/pb_glossary]<\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0are the structures where hairs originate (see the diagram\u00a0above). Hairs grow out of follicles, pass through the epidermis, and exit at the surface of the skin. Associated with each hair follicle is a sebaceous gland, which secretes sebum that coats and waterproofs the hair. Each follicle also has a bed of capillaries, a nerve ending, and a tiny muscle called an [pb_glossary id=\"5839\"]arrector pili[\/pb_glossary].<\/span>\r\n<div>\r\n<h1>Functions of the Dermis<\/h1>\r\n<\/div>\r\nThe main functions of the dermis are regulating body temperature, enabling the sense of touch, and eliminating wastes from the body.\r\n<h2>Temperature Regulation<\/h2>\r\nSeveral structures in the reticular layer of the dermis are involved in regulating body temperature. For example, when body temperature rises, the [pb_glossary id=\"2937\"]hypothalamus[\/pb_glossary] of the [pb_glossary id=\"5915\"]brain[\/pb_glossary] sends nerve signals to sweat glands, causing them to release sweat. An adult can sweat up to four litres an hour. As the sweat evaporates from the surface of the body, it uses energy in the form of body heat, thus cooling the body. The hypothalamus also causes dilation of blood vessels in the dermis when body temperature rises. This allows more blood to flow through the skin, bringing body heat to the surface, where it can radiate into the environment.\r\n\r\nWhen the body is too cool, sweat glands stop producing sweat, and blood vessels in the skin constrict, thus conserving body\u00a0heat. The arrector pili\u00a0muscles\u00a0also contract, moving hair follicles and lifting hair shafts. This results in more air being trapped under the hairs to insulate the surface of the skin. These contractions of arrector pili muscles are the cause of goose bumps.\r\n<h2>Sensing\u00a0the Environment<\/h2>\r\nSensory receptors in the dermis are mainly responsible for the body\u2019s tactile\u00a0senses. The receptors detect such tactile stimuli as warm or cold temperature, shape, texture, pressure, vibration, and pain. They send\u00a0nerve impulses\u00a0to the brain, which interprets and responds to the sensory information. Sensory receptors in the dermis can be classified on the basis of the type of touch stimulus they sense.\u00a0<strong>[pb_glossary id=\"3124\"]Mechanoreceptor<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\">[\/pb_glossary]<\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0sense mechanical forces such as pressure, roughness, vibration, and stretching.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\">[pb_glossary id=\"3125\"]Thermoreceptor<\/strong><strong style=\"font-size: 1em; text-align: initial;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\">[\/pb_glossary]<\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0sense variations in temperature that are above or below body temperature.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\">[pb_glossary id=\"3126\"]Nociceptor<\/strong><strong style=\"font-size: 1em; text-align: initial;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\">[\/pb_glossary]<\/strong><span style=\"text-align: initial; font-size: 1em;\"> sense painful stimuli. Figure 10.4.6 shows several specific kinds of tactile receptors in the dermis. Each kind of receptor senses one or more types of touch stimuli.<\/span>\r\n<ul>\r\n \t<li>Free nerve endings sense pain and temperature variations.<\/li>\r\n \t<li>Merkel\u00a0cells\u00a0sense light touch, shapes, and textures.<\/li>\r\n \t<li>Meissner\u2019s corpuscles sense light touch.<\/li>\r\n \t<li>Pacinian corpuscles sense pressure and vibration.<\/li>\r\n \t<li>Ruffini corpuscles sense stretching and sustained pressure.<\/li>\r\n<\/ul>\r\n[caption id=\"attachment_3574\" align=\"aligncenter\" width=\"836\"]<img class=\"wp-image-3574 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0809_Skin_TactileReceptors-e1591224860583-2.png\" alt=\"10.4 Tactile Receptors\" width=\"836\" height=\"669\" \/> <em>Figure 10.4.6 A variety of types of tactile receptors are located in the dermis of the skin.<\/em>[\/caption]\r\n<h2>Excreting Wastes<\/h2>\r\nThe sweat released by [pb_glossary id=\"3568\"]eccrine sweat gland<span style=\"font-size: 1em;\">s<\/span><span style=\"text-align: initial; font-size: 1em;\">[\/pb_glossary]<\/span><span style=\"text-align: initial; font-size: 1em;\">\u00a0is one way the body excretes waste products. Sweat contains excess\u00a0water, salts (electrolytes), and other waste products that the body must get rid of to maintain\u00a0[pb_glossary id=\"5761\"]homeostasis[\/pb_glossary]. The most common electrolytes in sweat are sodium and chloride. Potassium, calcium, and magnesium electrolytes may be excreted in sweat, as well. When these electrolytes reach high levels in the\u00a0blood, more are excreted in sweat. This helps to bring their blood levels back into balance. Besides electrolytes, sweat contains small amounts of waste products from [pb_glossary id=\"5773\"]metabolism[\/pb_glossary], including ammonia and urea. Sweat may also contain alcohol in someone who has been drinking alcoholic beverages.<\/span>\r\n<div>\r\n<h1>Feature: My\u00a0Human Body<\/h1>\r\n<\/div>\r\n\r\n[caption id=\"attachment_3575\" align=\"alignright\" width=\"343\"]<img class=\"wp-image-3575\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Akne-jugend-2.jpg\" alt=\"10.4.7\" width=\"343\" height=\"234\" \/> <em>Figure 10.4.7 Acne can be embarrassing, but most people will experience it at one point in their lives.<\/em>[\/caption]\r\n\r\n<strong>[pb_glossary id=\"3576\"]Acne[\/pb_glossary]<\/strong> is the most common skin disorder in the Canada. At least 20% of Canadians have acne at any given time and it affects approximately 90% of adolescents (as in Figure 10.4.7). Although acne occurs most commonly in teens and young adults, but it can occur at any age. Even newborn babies can get acne.\r\n\r\nThe main sign of acne is the appearance of pimples (pustules) on the skin, like those in the photo above. Other signs of acne may include whiteheads, blackheads, nodules, and other lesions. Besides the face, acne can appear on the back, chest, neck, shoulders, upper arms, and buttocks. Acne can permanently scar the skin, especially if it isn\u2019t treated appropriately. Besides its physical effects on the skin, acne can also lead to low self-esteem and depression.\r\n\r\nAcne is caused by clogged, sebum-filled pores that provide a perfect environment for the growth of\u00a0bacteria. The bacteria cause infection, and the immune system responds with inflammation. Inflammation, in turn, causes swelling and redness, and may be associated with the formation of pus. If the inflammation goes deep into the skin, it may form an acne nodule.\r\n\r\nMild acne often responds well to treatment with over-the-counter (OTC) products containing benzoyl peroxide or salicylic\u00a0acid. Treatment with these products may take a month or two to clear up the acne. Once the skin clears, treatment generally needs to continue for some time to prevent future breakouts.\r\n\r\nIf acne fails to respond to OTC products, nodules develop, or acne is affecting self-esteem, a visit to a dermatologist is in order. A dermatologist can determine which treatment is best for a given patient. A dermatologist can also prescribe prescription medications (which are likely to be more effective than OTC products) and provide other medical treatments, such as laser light therapies or chemical peels.\r\n\r\nWhat can you do to maintain healthy skin and prevent or reduce acne? Dermatologists recommend the following tips:\r\n<ul>\r\n \t<li>Wash affected or acne-prone skin (such as the face) twice a day, and after sweating.<\/li>\r\n \t<li>Use your fingertips to apply a gentle, non-abrasive cleanser. Avoid scrubbing, which can make acne worse.<\/li>\r\n \t<li>Use only alcohol-free products and avoid any products that irritate the skin, such as harsh astringents or exfoliants.<\/li>\r\n \t<li>Rinse with lukewarm\u00a0water, and avoid using very hot or cold water.<\/li>\r\n \t<li>Shampoo your hair regularly.<\/li>\r\n \t<li>Do not pick, pop, or squeeze acne. If you do, it will take longer to heal and is more likely to scar.<\/li>\r\n \t<li>Keep your hands off your face. Avoid touching your skin throughout the day.<\/li>\r\n \t<li>Stay out of the\u00a0sun\u00a0and tanning beds. Some acne medications make your skin very sensitive to UV light.<\/li>\r\n<\/ul>\r\n<div>\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Summary<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul>\r\n \t<li>The [pb_glossary id=\"5967\"]dermis[\/pb_glossary] is the inner and thicker of the two major layers that make up the skin. It consists mainly of a matrix of [pb_glossary id=\"2815\"]connective tissue[\/pb_glossary]s that provide strength and stretch. It also contains almost all skin structures, including [pb_glossary id=\"3006\"]sensory receptors[\/pb_glossary]\u00a0and [pb_glossary id=\"5835\"]blood vessel[\/pb_glossary]s.<\/li>\r\n \t<li>The dermis has two layers. The upper [pb_glossary id=\"5843\"]papillary layer[\/pb_glossary] has papillae extending upward into the epidermis and loose connective tissues. The lower [pb_glossary id=\"5847\"]reticular layer[\/pb_glossary] has denser connective tissues and structures, such as glands and hair follicles. Glands in the dermis include eccrine and apocrine sweat glands and sebaceous glands. Hair [pb_glossary id=\"6015\"]follicles[\/pb_glossary]\u00a0are structures where hairs originate.<\/li>\r\n \t<li>Functions of the dermis include cushioning subcutaneous tissues, regulating body temperature, sensing the environment, and excreting wastes. The dense connective tissues of the dermis provide cushioning. The dermis regulates body temperature mainly by sweating and by vasodilation or vasoconstriction. The many tactile sensory receptors in the dermis make it the main organ for the sense of touch. Wastes excreted in sweat include excess water, electrolytes, and certain metabolic wastes.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ol>\r\n \t<li>What is the dermis?<\/li>\r\n \t<li>Describe the basic anatomy of the dermis.<\/li>\r\n \t<li>Compare and contrast the papillary and reticular layers of the dermis.<\/li>\r\n \t<li>What causes epidermal ridges, and why can they be used to identify individuals?<\/li>\r\n \t<li>Name the two types of sweat glands in the dermis, and explain\u00a0how they differ.<\/li>\r\n \t<li>What is the function of sebaceous glands?<\/li>\r\n \t<li>Describe the structures associated with hair follicles.<\/li>\r\n \t<li>Explain how the dermis helps regulate body temperature.<\/li>\r\n \t<li>Identify three specific kinds of tactile receptors in the dermis, along with the type of stimuli they sense.<\/li>\r\n \t<li>How does the dermis excrete wastes? What waste products does it excrete?<\/li>\r\n \t<li>What are subcutaneous tissues?\u00a0Which layer of the dermis provides cushioning for subcutaneous tissues? Why does this layer provide most of the cushioning, instead of the other layer?<\/li>\r\n \t<li>For each of the functions listed below, describe which structure within the dermis carries it out.\r\n<ol type=\"a\">\r\n \t<li>Brings nutrients to and removes wastes from dermal and lower epidermal cells<\/li>\r\n \t<li>Causes hairs to move<\/li>\r\n \t<li>Detects painful stimuli on the skin<\/li>\r\n<\/ol>\r\n<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE\r\n<p style=\"text-align: center;\">How do you get rid of acne? SciShow, 2016.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;feature=emb_logo\r\n<p style=\"text-align: center;\">When You Can't Scratch Away An Itch, Seeker, 2013.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n&nbsp;\r\n\r\n<\/div>\r\n<h2>Attributions<\/h2>\r\n<strong>Figure 10.4.1<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Goose_bumps.jpg\" rel=\"cc:attributionURL\">Goose_bumps<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/photos\/61532128@N00\" rel=\"nofollow\">EverJean<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.\r\n\r\n<strong>Figure 10.4.2<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:506_Layers_of_the_Dermis.jpg\" rel=\"cc:attributionURL\">Layers_of_the_Dermis<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\r\n\r\n<strong>Figure 10.4.3<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Fingerprint_detail_on_male_finger_in_T%C5%99eb%C3%AD%C4%8D,_T%C5%99eb%C3%AD%C4%8D_District.jpg\" rel=\"cc:attributionURL\">Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d,_T\u0159eb\u00ed\u010d_District<\/a> by <a title=\"User:Frettie\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Frettie\">Frettie<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\r\n\r\n<strong style=\"text-align: initial; font-size: 1em;\">Figure 10.4.4<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0802_Skin_DermalCirculation.png\" rel=\"cc:attributionURL\">Blausen_0802_Skin_Dermal Circulation<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial; font-size: 1em;\">\u00a0<a style=\"text-align: initial; font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span>\r\n\r\n<strong>Figure 10.4.5<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anatomy_The_Skin_-_NCI_Visuals_Online.jpg\" rel=\"cc:attributionURL\">Anatomy_The_Skin_-_NCI_Visuals_Online<\/a>\u00a0by Don Bliss (artist) \/ \u00a0<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a class=\"extiw\" title=\"en:National Institutes of Health\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Institutes_of_Health\">National Institutes of Health<\/a>, with the ID\u00a0<a class=\"external text\" href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4604\" rel=\"nofollow\">4604<\/a>) is in the<span style=\"font-size: 1em;\"> <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/span><span style=\"text-align: initial; font-size: 1em;\">\u00a0<\/span>\r\n\r\n<strong>Figure 10.4.6<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0809_Skin_TactileReceptors.png\" rel=\"cc:attributionURL\">Blausen_0809_Skin_TactileReceptors<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial; font-size: 1em;\">\u00a0<a style=\"text-align: initial; font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span>\r\n\r\n<strong>Figure 10.4.7<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Akne-jugend.jpg\" rel=\"cc:attributionURL\">Akne-jugend<\/a> by <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> <span style=\"font-size: 1em;\">(https:\/\/en.wikipedia.org\/wiki\/public_domain)<\/span>. (No machine-readable author provided. <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a>\u00a0assumed, based on copyright claims).\r\n<h2>References<\/h2>\r\n<p class=\"hanging-indent\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure 5.7 Layers of the dermis [digital image]. In <em>Anatomy and Physiology<\/em> (Section 5.1 Layers of the skin). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin<\/p>\r\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\r\n<p class=\"hanging-indent\">SciShow. (2016, October 26). How do you get rid of acne? YouTube. https:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE<\/p>\r\n<p class=\"hanging-indent\">Seeker. (2013, October 26). When you can't scratch away an itch. YouTube. https:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;amp;feature=emb_logo<\/p>","rendered":"<p>&nbsp;<\/p>\n<div>\n<figure id=\"attachment_3560\" aria-describedby=\"caption-attachment-3560\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3560\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Goose_bumps-2.jpg\" alt=\"10.4.1\" width=\"400\" height=\"209\" \/><figcaption id=\"caption-attachment-3560\" class=\"wp-caption-text\"><em>Figure 10.4.1 Goose bumps!<\/em><\/figcaption><\/figure>\n<h1>Goose Bumps<\/h1>\n<\/div>\n<p>No doubt you\u2019ve experienced the tiny, hair-raising skin bumps called goose bumps, like those you see in Figure 10.4.1. They happen when you feel chilly. Do you know what causes goose bumps, or why they pop up when you are cold? The answers to these questions involve the layer of skin known as the dermis.<\/p>\n<div>\n<h1>What is the Dermis?<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5967\">dermis<\/a><\/strong>\u00a0is the inner of the two major layers that make up the skin, the outer layer being the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5991\">epidermis<\/a><\/strong>. The dermis consists mainly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2815\">connective tissues<\/a>. It also contains most skin structures, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2936\">glands<\/a>\u00a0and\u00a0blood vessels. The dermis is anchored to the tissues below it by flexible collagen bundles that permit most areas of the skin to move freely over subcutaneous (\u201cbelow the skin\u201d) tissues. Functions of the dermis include cushioning subcutaneous tissues, regulating body\u00a0temperature, sensing\u00a0the environment, and excreting wastes.<\/p>\n<div>\n<h1>Anatomy of the Dermis<\/h1>\n<\/div>\n<p>The basic anatomy of the dermis is a matrix, or sort of scaffolding, composed of connective tissues. These tissues include collagen fibres \u2014 which provide toughness \u2014 and elastin fibres, which provide elasticity. Surrounding these fibres, the matrix also includes a gel-like substance made of proteins. The tissues of the matrix give the dermis both strength and flexibility.<\/p>\n<p>The dermis is divided into two layers: the papillary layer and the reticular layer. Both layers are shown in Figure 10.4.2 below and described in the text that follows.<\/p>\n<figure id=\"attachment_3561\" aria-describedby=\"caption-attachment-3561\" style=\"width: 376px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3561\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Layers_of_the_Dermis-2.jpg\" alt=\"Layers of the Dermis\" width=\"376\" height=\"485\" \/><figcaption id=\"caption-attachment-3561\" class=\"wp-caption-text\"><em>Figure 10.4.2 This photomicrograph shows a cross-section of the papillary and reticular layers of the dermis.<\/em><\/figcaption><\/figure>\n<h2>Papillary Layer<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5843\">papillary layer<\/a><\/strong> is the upper layer of the dermis, just below the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5907\">basement membrane<\/a> that connects the dermis to the epidermis above it. The papillary layer is the thinner of the two dermal layers. It is composed mainly of loosely arranged collagen fibres. The papillary layer is named for its fingerlike projections \u2014 or papillae \u2014 that extend upward into the epidermis. The papillae contain capillaries and sensory touch receptors.<\/p>\n<figure id=\"attachment_3563\" aria-describedby=\"caption-attachment-3563\" style=\"width: 390px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3563\" src=\"http:\/\/humanbiology.pressbooks.tru.ca\/wp-content\/uploads\/sites\/6\/2019\/06\/Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d_T\u0159eb\u00ed\u010d_District.jpg#fixme\" alt=\"10.3 Fingerprints\" width=\"390\" height=\"260\" \/><figcaption id=\"caption-attachment-3563\" class=\"wp-caption-text\"><em>Figure 10.4.3 This photo is an enlarged image of epidermal ridges on a finger.<\/em><\/figcaption><\/figure>\n<p>The papillae give the dermis a bumpy surface that interlocks with the epidermis above it, strengthening the connection between the two layers of skin. On the palms and soles, the papillae create epidermal ridges. Epidermal ridges on the fingers are commonly called fingerprints (see Figure 10.4.3). Fingerprints are genetically determined, so no two people (other than identical twins) have exactly the same fingerprint pattern. Therefore, fingerprints can be used as a means of identification, for example, at crime scenes. Fingerprints were much more commonly used forensically before DNA analysis was introduced for this purpose.<\/p>\n<h2>Reticular Layer<\/h2>\n<p>The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5847\"><strong>reticular layer<\/strong> <\/a>is the lower layer of the dermis, located below the papillary layer. It is the thicker of the two dermal layers. It is composed of densely woven collagen and elastin fibres. These protein fibres give the dermis its properties of strength and elasticity. This layer of the dermis cushions subcutaneous tissues of the body from stress and strain. The reticular layer of the dermis also contains most of the structures in the dermis, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2936\">glands<\/a> and hair <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_6015\">follicle<span style=\"font-size: 1em;\">s<\/span><span style=\"text-align: initial; font-size: 1em;\"><\/a><\/span><span style=\"text-align: initial; font-size: 1em;\">.<\/span><\/p>\n<div>\n<h1>Structures in the Dermis<\/h1>\n<\/div>\n<p>Both papillary and reticular layers of the dermis contain numerous <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3006\">sensory receptors<\/a>, which make the skin the body\u2019s primary sensory organ for the sense of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3129\">touch<\/a>. Both dermal layers also contain blood vessels. They provide nutrients to remove wastes from dermal cells, as well as cells in the lowest layer of the epidermis, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3542\">stratum basale<\/a>. The circulatory components of the dermis are shown in Figure 10.4.4 below.<\/p>\n<figure id=\"attachment_3565\" aria-describedby=\"caption-attachment-3565\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3565\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0802_Skin_DermalCirculation-2.png\" alt=\"10.3 Dermal Circulation\" width=\"1024\" height=\"819\" \/><figcaption id=\"caption-attachment-3565\" class=\"wp-caption-text\"><em>Figure 10.4.4 Both the papillary layer and the reticular layer of the dermis contain blood vessels, as shown in this diagram.<\/em><\/figcaption><\/figure>\n<h2>Glands<\/h2>\n<p>Glands in the reticular layer of the dermis include sweat glands and sebaceous (oil) glands. Both are exocrine glands, which are glands that release their secretions through ducts to nearby body surfaces. The diagram in Figure 10.4.5 shows these glands, as well as several other structures in the dermis.<\/p>\n<figure id=\"attachment_3567\" aria-describedby=\"caption-attachment-3567\" style=\"width: 702px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3567\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anatomy_The_Skin_-_NCI_Visuals_Online-1-e1591224136617-2.jpg\" alt=\"10.4 Skin Glands\" width=\"702\" height=\"580\" \/><figcaption id=\"caption-attachment-3567\" class=\"wp-caption-text\"><em>Figure 10.4.5 The dermis contains sweat and oil (sebaceous) glands, as well as hair follicles and blood vessels.<\/em><\/figcaption><\/figure>\n<h3>Sweat Glands<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3566\">Sweat glands<\/a><\/strong>\u00a0produce the fluid called sweat, which contains mainly\u00a0water\u00a0and salts. The glands have ducts that carry the sweat to\u00a0hair\u00a0follicles, or to the surface of the skin. There are two different types of sweat glands: eccrine glands and apocrine glands.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3568\">Eccrine sweat gland<strong>s<\/strong><\/a><\/strong>\u00a0occur in skin all over the body. Their ducts empty through tiny openings called pores onto the skin surface. These sweat glands are involved in\u00a0temperature\u00a0regulation.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3569\">Apocrine sweat gland<strong>s<\/strong><\/a><\/strong>\u00a0are larger than eccrine glands, and occur only in the skin of the armpits and groin. The ducts of apocrine glands empty into hair follicles, and then the sweat travels along hairs to reach the surface. Apocrine glands are inactive until\u00a0puberty, at which point they start producing an oily sweat that is consumed by\u00a0bacteria\u00a0living on the skin. The digestion of apocrine sweat by bacteria\u00a0causes\u00a0body odor.<\/li>\n<\/ul>\n<h3>Sebaceous Glands<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3570\">Sebaceous gland<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0are exocrine glands that produce a thick, fatty substance called sebum.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3571\">Sebum<\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0is secreted into hair follicles and makes its way to the skin surface along hairs. It waterproofs the hair and skin, and helps prevent them from drying out. Sebum also has antibacterial properties, so it inhibits the growth of microorganisms on the skin. Sebaceous glands are found in every part of the skin \u2014 except for the palms of the hands and soles of the feet, where hair does not grow.<\/span><\/p>\n<h2>Hair Follicles<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3572\">Hair follicle<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0are the structures where hairs originate (see the diagram\u00a0above). Hairs grow out of follicles, pass through the epidermis, and exit at the surface of the skin. Associated with each hair follicle is a sebaceous gland, which secretes sebum that coats and waterproofs the hair. Each follicle also has a bed of capillaries, a nerve ending, and a tiny muscle called an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5839\">arrector pili<\/a>.<\/span><\/p>\n<div>\n<h1>Functions of the Dermis<\/h1>\n<\/div>\n<p>The main functions of the dermis are regulating body temperature, enabling the sense of touch, and eliminating wastes from the body.<\/p>\n<h2>Temperature Regulation<\/h2>\n<p>Several structures in the reticular layer of the dermis are involved in regulating body temperature. For example, when body temperature rises, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2937\">hypothalamus<\/a> of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5915\">brain<\/a> sends nerve signals to sweat glands, causing them to release sweat. An adult can sweat up to four litres an hour. As the sweat evaporates from the surface of the body, it uses energy in the form of body heat, thus cooling the body. The hypothalamus also causes dilation of blood vessels in the dermis when body temperature rises. This allows more blood to flow through the skin, bringing body heat to the surface, where it can radiate into the environment.<\/p>\n<p>When the body is too cool, sweat glands stop producing sweat, and blood vessels in the skin constrict, thus conserving body\u00a0heat. The arrector pili\u00a0muscles\u00a0also contract, moving hair follicles and lifting hair shafts. This results in more air being trapped under the hairs to insulate the surface of the skin. These contractions of arrector pili muscles are the cause of goose bumps.<\/p>\n<h2>Sensing\u00a0the Environment<\/h2>\n<p>Sensory receptors in the dermis are mainly responsible for the body\u2019s tactile\u00a0senses. The receptors detect such tactile stimuli as warm or cold temperature, shape, texture, pressure, vibration, and pain. They send\u00a0nerve impulses\u00a0to the brain, which interprets and responds to the sensory information. Sensory receptors in the dermis can be classified on the basis of the type of touch stimulus they sense.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3124\">Mechanoreceptor<\/strong><strong style=\"font-size: 1em;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0sense mechanical forces such as pressure, roughness, vibration, and stretching.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3125\">Thermoreceptor<\/strong><strong style=\"font-size: 1em; text-align: initial;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\">\u00a0sense variations in temperature that are above or below body temperature.\u00a0<\/span><strong style=\"text-align: initial; font-size: 1em;\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3126\">Nociceptor<\/strong><strong style=\"font-size: 1em; text-align: initial;\">s<\/strong><strong style=\"text-align: initial; font-size: 1em;\"><\/a><\/strong><span style=\"text-align: initial; font-size: 1em;\"> sense painful stimuli. Figure 10.4.6 shows several specific kinds of tactile receptors in the dermis. Each kind of receptor senses one or more types of touch stimuli.<\/span><\/p>\n<ul>\n<li>Free nerve endings sense pain and temperature variations.<\/li>\n<li>Merkel\u00a0cells\u00a0sense light touch, shapes, and textures.<\/li>\n<li>Meissner\u2019s corpuscles sense light touch.<\/li>\n<li>Pacinian corpuscles sense pressure and vibration.<\/li>\n<li>Ruffini corpuscles sense stretching and sustained pressure.<\/li>\n<\/ul>\n<figure id=\"attachment_3574\" aria-describedby=\"caption-attachment-3574\" style=\"width: 836px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3574\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0809_Skin_TactileReceptors-e1591224860583-2.png\" alt=\"10.4 Tactile Receptors\" width=\"836\" height=\"669\" \/><figcaption id=\"caption-attachment-3574\" class=\"wp-caption-text\"><em>Figure 10.4.6 A variety of types of tactile receptors are located in the dermis of the skin.<\/em><\/figcaption><\/figure>\n<h2>Excreting Wastes<\/h2>\n<p>The sweat released by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3568\">eccrine sweat gland<span style=\"font-size: 1em;\">s<\/span><span style=\"text-align: initial; font-size: 1em;\"><\/a><\/span><span style=\"text-align: initial; font-size: 1em;\">\u00a0is one way the body excretes waste products. Sweat contains excess\u00a0water, salts (electrolytes), and other waste products that the body must get rid of to maintain\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5761\">homeostasis<\/a>. The most common electrolytes in sweat are sodium and chloride. Potassium, calcium, and magnesium electrolytes may be excreted in sweat, as well. When these electrolytes reach high levels in the\u00a0blood, more are excreted in sweat. This helps to bring their blood levels back into balance. Besides electrolytes, sweat contains small amounts of waste products from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5773\">metabolism<\/a>, including ammonia and urea. Sweat may also contain alcohol in someone who has been drinking alcoholic beverages.<\/span><\/p>\n<div>\n<h1>Feature: My\u00a0Human Body<\/h1>\n<\/div>\n<figure id=\"attachment_3575\" aria-describedby=\"caption-attachment-3575\" style=\"width: 343px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3575\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Akne-jugend-2.jpg\" alt=\"10.4.7\" width=\"343\" height=\"234\" \/><figcaption id=\"caption-attachment-3575\" class=\"wp-caption-text\"><em>Figure 10.4.7 Acne can be embarrassing, but most people will experience it at one point in their lives.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3576\">Acne<\/a><\/strong> is the most common skin disorder in the Canada. At least 20% of Canadians have acne at any given time and it affects approximately 90% of adolescents (as in Figure 10.4.7). Although acne occurs most commonly in teens and young adults, but it can occur at any age. Even newborn babies can get acne.<\/p>\n<p>The main sign of acne is the appearance of pimples (pustules) on the skin, like those in the photo above. Other signs of acne may include whiteheads, blackheads, nodules, and other lesions. Besides the face, acne can appear on the back, chest, neck, shoulders, upper arms, and buttocks. Acne can permanently scar the skin, especially if it isn\u2019t treated appropriately. Besides its physical effects on the skin, acne can also lead to low self-esteem and depression.<\/p>\n<p>Acne is caused by clogged, sebum-filled pores that provide a perfect environment for the growth of\u00a0bacteria. The bacteria cause infection, and the immune system responds with inflammation. Inflammation, in turn, causes swelling and redness, and may be associated with the formation of pus. If the inflammation goes deep into the skin, it may form an acne nodule.<\/p>\n<p>Mild acne often responds well to treatment with over-the-counter (OTC) products containing benzoyl peroxide or salicylic\u00a0acid. Treatment with these products may take a month or two to clear up the acne. Once the skin clears, treatment generally needs to continue for some time to prevent future breakouts.<\/p>\n<p>If acne fails to respond to OTC products, nodules develop, or acne is affecting self-esteem, a visit to a dermatologist is in order. A dermatologist can determine which treatment is best for a given patient. A dermatologist can also prescribe prescription medications (which are likely to be more effective than OTC products) and provide other medical treatments, such as laser light therapies or chemical peels.<\/p>\n<p>What can you do to maintain healthy skin and prevent or reduce acne? Dermatologists recommend the following tips:<\/p>\n<ul>\n<li>Wash affected or acne-prone skin (such as the face) twice a day, and after sweating.<\/li>\n<li>Use your fingertips to apply a gentle, non-abrasive cleanser. Avoid scrubbing, which can make acne worse.<\/li>\n<li>Use only alcohol-free products and avoid any products that irritate the skin, such as harsh astringents or exfoliants.<\/li>\n<li>Rinse with lukewarm\u00a0water, and avoid using very hot or cold water.<\/li>\n<li>Shampoo your hair regularly.<\/li>\n<li>Do not pick, pop, or squeeze acne. If you do, it will take longer to heal and is more likely to scar.<\/li>\n<li>Keep your hands off your face. Avoid touching your skin throughout the day.<\/li>\n<li>Stay out of the\u00a0sun\u00a0and tanning beds. Some acne medications make your skin very sensitive to UV light.<\/li>\n<\/ul>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5967\">dermis<\/a> is the inner and thicker of the two major layers that make up the skin. It consists mainly of a matrix of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2815\">connective tissue<\/a>s that provide strength and stretch. It also contains almost all skin structures, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3006\">sensory receptors<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5835\">blood vessel<\/a>s.<\/li>\n<li>The dermis has two layers. The upper <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5843\">papillary layer<\/a> has papillae extending upward into the epidermis and loose connective tissues. The lower <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_5847\">reticular layer<\/a> has denser connective tissues and structures, such as glands and hair follicles. Glands in the dermis include eccrine and apocrine sweat glands and sebaceous glands. Hair <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_6015\">follicles<\/a>\u00a0are structures where hairs originate.<\/li>\n<li>Functions of the dermis include cushioning subcutaneous tissues, regulating body temperature, sensing the environment, and excreting wastes. The dense connective tissues of the dermis provide cushioning. The dermis regulates body temperature mainly by sweating and by vasodilation or vasoconstriction. The many tactile sensory receptors in the dermis make it the main organ for the sense of touch. Wastes excreted in sweat include excess water, electrolytes, and certain metabolic wastes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is the dermis?<\/li>\n<li>Describe the basic anatomy of the dermis.<\/li>\n<li>Compare and contrast the papillary and reticular layers of the dermis.<\/li>\n<li>What causes epidermal ridges, and why can they be used to identify individuals?<\/li>\n<li>Name the two types of sweat glands in the dermis, and explain\u00a0how they differ.<\/li>\n<li>What is the function of sebaceous glands?<\/li>\n<li>Describe the structures associated with hair follicles.<\/li>\n<li>Explain how the dermis helps regulate body temperature.<\/li>\n<li>Identify three specific kinds of tactile receptors in the dermis, along with the type of stimuli they sense.<\/li>\n<li>How does the dermis excrete wastes? What waste products does it excrete?<\/li>\n<li>What are subcutaneous tissues?\u00a0Which layer of the dermis provides cushioning for subcutaneous tissues? Why does this layer provide most of the cushioning, instead of the other layer?<\/li>\n<li>For each of the functions listed below, describe which structure within the dermis carries it out.\n<ol type=\"a\">\n<li>Brings nutrients to and removes wastes from dermal and lower epidermal cells<\/li>\n<li>Causes hairs to move<\/li>\n<li>Detects painful stimuli on the skin<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"How to Get Rid of Acne For Good\u2014According to Science\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/FX-FwK0IIrE?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">How do you get rid of acne? SciShow, 2016.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"When You Can&#39;t Scratch Away An Itch\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/VcHQWMAClhQ?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">When You Can&#8217;t Scratch Away An Itch, Seeker, 2013.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 10.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Goose_bumps.jpg\" rel=\"cc:attributionURL\">Goose_bumps<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/photos\/61532128@N00\" rel=\"nofollow\">EverJean<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 10.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:506_Layers_of_the_Dermis.jpg\" rel=\"cc:attributionURL\">Layers_of_the_Dermis<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 10.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Fingerprint_detail_on_male_finger_in_T%C5%99eb%C3%AD%C4%8D,_T%C5%99eb%C3%AD%C4%8D_District.jpg\" rel=\"cc:attributionURL\">Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d,_T\u0159eb\u00ed\u010d_District<\/a> by <a title=\"User:Frettie\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Frettie\">Frettie<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong style=\"text-align: initial; font-size: 1em;\">Figure 10.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0802_Skin_DermalCirculation.png\" rel=\"cc:attributionURL\">Blausen_0802_Skin_Dermal Circulation<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial; font-size: 1em;\">\u00a0<a style=\"text-align: initial; font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anatomy_The_Skin_-_NCI_Visuals_Online.jpg\" rel=\"cc:attributionURL\">Anatomy_The_Skin_-_NCI_Visuals_Online<\/a>\u00a0by Don Bliss (artist) \/ \u00a0<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a class=\"extiw\" title=\"en:National Institutes of Health\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Institutes_of_Health\">National Institutes of Health<\/a>, with the ID\u00a0<a class=\"external text\" href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4604\" rel=\"nofollow\">4604<\/a>) is in the<span style=\"font-size: 1em;\"> <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/span><span style=\"text-align: initial; font-size: 1em;\">\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0809_Skin_TactileReceptors.png\" rel=\"cc:attributionURL\">Blausen_0809_Skin_TactileReceptors<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial; font-size: 1em;\">\u00a0<a style=\"text-align: initial; font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Akne-jugend.jpg\" rel=\"cc:attributionURL\">Akne-jugend<\/a> by <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> <span style=\"font-size: 1em;\">(https:\/\/en.wikipedia.org\/wiki\/public_domain)<\/span>. (No machine-readable author provided. <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a>\u00a0assumed, based on copyright claims).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure 5.7 Layers of the dermis [digital image]. In <em>Anatomy and Physiology<\/em> (Section 5.1 Layers of the skin). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin<\/p>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">SciShow. (2016, October 26). How do you get rid of acne? YouTube. https:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE<\/p>\n<p class=\"hanging-indent\">Seeker. (2013, October 26). When you can&#8217;t scratch away an itch. YouTube. https:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;amp;feature=emb_logo<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4877_5967\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5967\"><div tabindex=\"-1\"><p>The inner layer of skin that is made of tough connective tissue and contains blood vessels, nerve endings, hair follicles, and glands.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5991\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5991\"><div tabindex=\"-1\"><p>The outer layer of skin that consists mainly of epithelial cells and lacks nerve endings, blood vessels, and other structures.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_2815\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_2815\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<div>\n<figure id=\"attachment_3560\" aria-describedby=\"caption-attachment-3560\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-3560\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Goose_bumps.jpg\" alt=\"10.4.1\" width=\"400\" height=\"209\"><figcaption id=\"caption-attachment-3560\" class=\"wp-caption-text\"><em>Figure 10.4.1 Goose bumps!<\/em><\/figcaption><\/figure>\n<h1>Goose Bumps<\/h1>\n<\/div>\n<p>No doubt you\u2019ve experienced the tiny, hair-raising skin bumps called goose bumps, like those you see in Figure 10.4.1. They happen when you feel chilly. Do you know what causes goose bumps, or why they pop up when you are cold? The answers to these questions involve the layer of skin known as the dermis.<\/p>\n<div>\n<h1>What is the Dermis?<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2625\">dermis<\/a><\/strong>\u00a0is the inner of the two major layers that make up the skin, the outer layer being the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2655\">epidermis<\/a><\/strong>. The dermis consists mainly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2815\">connective tissues<\/a>. It also contains most skin structures, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2936\">glands<\/a>\u00a0and\u00a0blood vessels. The dermis is anchored to the tissues below it by flexible collagen bundles that permit most areas of the skin to move freely over subcutaneous (\u201cbelow the skin\u201d) tissues. Functions of the dermis include cushioning subcutaneous tissues, regulating body\u00a0temperature, sensing\u00a0the environment, and excreting wastes.<\/p>\n<div>\n<h1>Anatomy of the Dermis<\/h1>\n<\/div>\n<p>The basic anatomy of the dermis is a matrix, or sort of scaffolding, composed of connective tissues. These tissues include collagen fibres \u2014 which provide toughness \u2014 and elastin fibres, which provide elasticity. Surrounding these fibres, the matrix also includes a gel-like substance made of proteins. The tissues of the matrix give the dermis both strength and flexibility.<\/p>\n<p>The dermis is divided into two layers: the papillary layer and the reticular layer. Both layers are shown in Figure 10.4.2 below and described in the text that follows.<\/p>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 376px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-853\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Layers_of_the_Dermis.jpg\" alt=\"Layers of the Dermis\" width=\"376\" height=\"485\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.2 This photomicrograph shows a cross-section of the papillary and reticular layers of the dermis.<\/em><\/figcaption><\/figure>\n<h2>Papillary Layer<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2460\">papillary layer<\/a><\/strong> is the upper layer of the dermis, just below the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2544\">basement membrane<\/a> that connects the dermis to the epidermis above it. The papillary layer is the thinner of the two dermal layers. It is composed mainly of loosely arranged collagen fibres. The papillary layer is named for its fingerlike projections \u2014 or papillae \u2014 that extend upward into the epidermis. The papillae contain capillaries and sensory touch receptors.<\/p>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 390px\" class=\"wp-caption alignleft\"><img class=\" wp-image-3563\" src=\"http:\/\/humanbiology.pressbooks.tru.ca\/wp-content\/uploads\/sites\/6\/2019\/06\/Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d_T\u0159eb\u00ed\u010d_District.jpg#fixme\" alt=\"10.3 Fingerprints\" width=\"390\" height=\"260\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.3 This photo is an enlarged image of epidermal ridges on a finger.<\/em><\/figcaption><\/figure>\n<p>The papillae give the dermis a bumpy surface that interlocks with the epidermis above it, strengthening the connection between the two layers of skin. On the palms and soles, the papillae create epidermal ridges. Epidermal ridges on the fingers are commonly called fingerprints (see Figure 10.4.3). Fingerprints are genetically determined, so no two people (other than identical twins) have exactly the same fingerprint pattern. Therefore, fingerprints can be used as a means of identification, for example, at crime scenes. Fingerprints were much more commonly used forensically before DNA analysis was introduced for this purpose.<\/p>\n<h2>Reticular Layer<\/h2>\n<p>The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2465\"><strong>reticular layer<\/strong> <\/a>is the lower layer of the dermis, located below the papillary layer. It is the thicker of the two dermal layers. It is composed of densely woven collagen and elastin fibres. These protein fibres give the dermis its properties of strength and elasticity. This layer of the dermis cushions subcutaneous tissues of the body from stress and strain. The reticular layer of the dermis also contains most of the structures in the dermis, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2936\">glands<\/a> and hair <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2684\">follicle<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">.<\/span><\/p>\n<div>\n<h1>Structures in the Dermis<\/h1>\n<\/div>\n<p>Both papillary and reticular layers of the dermis contain numerous <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3006\">sensory receptors<\/a>, which make the skin the body\u2019s primary sensory organ for the sense of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3129\">touch<\/a>. Both dermal layers also contain blood vessels. They provide nutrients to remove wastes from dermal cells, as well as cells in the lowest layer of the epidermis, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3542\">stratum basale<\/a>. The circulatory components of the dermis are shown in Figure 10.4.4 below.<\/p>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-854\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0802_Skin_DermalCirculation.png\" alt=\"10.3 Dermal Circulation\" width=\"1024\" height=\"819\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.4 Both the papillary layer and the reticular layer of the dermis contain blood vessels, as shown in this diagram.<\/em><\/figcaption><\/figure>\n<h2>Glands<\/h2>\n<p>Glands in the reticular layer of the dermis include sweat glands and sebaceous (oil) glands. Both are exocrine glands, which are glands that release their secretions through ducts to nearby body surfaces. The diagram in Figure 10.4.5 shows these glands, as well as several other structures in the dermis.<\/p>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 702px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-856 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anatomy_The_Skin_-_NCI_Visuals_Online-1-e1591224136617.jpg\" alt=\"10.4 Skin Glands\" width=\"702\" height=\"580\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.5 The dermis contains sweat and oil (sebaceous) glands, as well as hair follicles and blood vessels.<\/em><\/figcaption><\/figure>\n<h3>Sweat Glands<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3566\">Sweat glands<\/a><\/strong>\u00a0produce the fluid called sweat, which contains mainly\u00a0water\u00a0and salts. The glands have ducts that carry the sweat to\u00a0hair\u00a0follicles, or to the surface of the skin. There are two different types of sweat glands: eccrine glands and apocrine glands.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3568\">Eccrine sweat gland<strong>s<\/strong><\/a><\/strong>\u00a0occur in skin all over the body. Their ducts empty through tiny openings called pores onto the skin surface. These sweat glands are involved in\u00a0temperature\u00a0regulation.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3569\">Apocrine sweat gland<strong>s<\/strong><\/a><\/strong>\u00a0are larger than eccrine glands, and occur only in the skin of the armpits and groin. The ducts of apocrine glands empty into hair follicles, and then the sweat travels along hairs to reach the surface. Apocrine glands are inactive until\u00a0puberty, at which point they start producing an oily sweat that is consumed by\u00a0bacteria\u00a0living on the skin. The digestion of apocrine sweat by bacteria\u00a0causes\u00a0body odor.<\/li>\n<\/ul>\n<h3>Sebaceous Glands<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3570\">Sebaceous gland<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0are exocrine glands that produce a thick, fatty substance called sebum.\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3571\">Sebum<\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0is secreted into hair follicles and makes its way to the skin surface along hairs. It waterproofs the hair and skin, and helps prevent them from drying out. Sebum also has antibacterial properties, so it inhibits the growth of microorganisms on the skin. Sebaceous glands are found in every part of the skin \u2014 except for the palms of the hands and soles of the feet, where hair does not grow.<\/span><\/p>\n<h2>Hair Follicles<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3572\">Hair follicle<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0are the structures where hairs originate (see the diagram\u00a0above). Hairs grow out of follicles, pass through the epidermis, and exit at the surface of the skin. Associated with each hair follicle is a sebaceous gland, which secretes sebum that coats and waterproofs the hair. Each follicle also has a bed of capillaries, a nerve ending, and a tiny muscle called an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2454\">arrector pili<\/a>.<\/span><\/p>\n<div>\n<h1>Functions of the Dermis<\/h1>\n<\/div>\n<p>The main functions of the dermis are regulating body temperature, enabling the sense of touch, and eliminating wastes from the body.<\/p>\n<h2>Temperature Regulation<\/h2>\n<p>Several structures in the reticular layer of the dermis are involved in regulating body temperature. For example, when body temperature rises, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2937\">hypothalamus<\/a> of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2554\">brain<\/a> sends nerve signals to sweat glands, causing them to release sweat. An adult can sweat up to four litres an hour. As the sweat evaporates from the surface of the body, it uses energy in the form of body heat, thus cooling the body. The hypothalamus also causes dilation of blood vessels in the dermis when body temperature rises. This allows more blood to flow through the skin, bringing body heat to the surface, where it can radiate into the environment.<\/p>\n<p>When the body is too cool, sweat glands stop producing sweat, and blood vessels in the skin constrict, thus conserving body\u00a0heat. The arrector pili\u00a0muscles\u00a0also contract, moving hair follicles and lifting hair shafts. This results in more air being trapped under the hairs to insulate the surface of the skin. These contractions of arrector pili muscles are the cause of goose bumps.<\/p>\n<h2>Sensing\u00a0the Environment<\/h2>\n<p>Sensory receptors in the dermis are mainly responsible for the body\u2019s tactile\u00a0senses. The receptors detect such tactile stimuli as warm or cold temperature, shape, texture, pressure, vibration, and pain. They send\u00a0nerve impulses\u00a0to the brain, which interprets and responds to the sensory information. Sensory receptors in the dermis can be classified on the basis of the type of touch stimulus they sense.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3124\">Mechanoreceptor<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0sense mechanical forces such as pressure, roughness, vibration, and stretching.\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3125\">Thermoreceptor<\/strong><strong style=\"font-size: 1em;text-align: initial\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0sense variations in temperature that are above or below body temperature.\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3126\">Nociceptor<\/strong><strong style=\"font-size: 1em;text-align: initial\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\"> sense painful stimuli. Figure 10.4.6 shows several specific kinds of tactile receptors in the dermis. Each kind of receptor senses one or more types of touch stimuli.<\/span><\/p>\n<ul>\n<li>Free nerve endings sense pain and temperature variations.<\/li>\n<li>Merkel\u00a0cells\u00a0sense light touch, shapes, and textures.<\/li>\n<li>Meissner\u2019s corpuscles sense light touch.<\/li>\n<li>Pacinian corpuscles sense pressure and vibration.<\/li>\n<li>Ruffini corpuscles sense stretching and sustained pressure.<\/li>\n<\/ul>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 836px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-858 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0809_Skin_TactileReceptors-e1591224860583.png\" alt=\"10.4 Tactile Receptors\" width=\"836\" height=\"669\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.6 A variety of types of tactile receptors are located in the dermis of the skin.<\/em><\/figcaption><\/figure>\n<h2>Excreting Wastes<\/h2>\n<p>The sweat released by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3568\">eccrine sweat gland<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0is one way the body excretes waste products. Sweat contains excess\u00a0water, salts (electrolytes), and other waste products that the body must get rid of to maintain\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2350\">homeostasis<\/a>. The most common electrolytes in sweat are sodium and chloride. Potassium, calcium, and magnesium electrolytes may be excreted in sweat, as well. When these electrolytes reach high levels in the\u00a0blood, more are excreted in sweat. This helps to bring their blood levels back into balance. Besides electrolytes, sweat contains small amounts of waste products from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2368\">metabolism<\/a>, including ammonia and urea. Sweat may also contain alcohol in someone who has been drinking alcoholic beverages.<\/span><\/p>\n<div>\n<h1>Feature: My\u00a0Human Body<\/h1>\n<\/div>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 343px\" class=\"wp-caption alignright\"><img class=\"wp-image-861\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Akne-jugend.jpg\" alt=\"10.4.7\" width=\"343\" height=\"234\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.7 Acne can be embarrassing, but most people will experience it at one point in their lives.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3576\">Acne<\/a><\/strong> is the most common skin disorder in the Canada. At least 20% of Canadians have acne at any given time and it affects approximately 90% of adolescents (as in Figure 10.4.7). Although acne occurs most commonly in teens and young adults, but it can occur at any age. Even newborn babies can get acne.<\/p>\n<p>The main sign of acne is the appearance of pimples (pustules) on the skin, like those in the photo above. Other signs of acne may include whiteheads, blackheads, nodules, and other lesions. Besides the face, acne can appear on the back, chest, neck, shoulders, upper arms, and buttocks. Acne can permanently scar the skin, especially if it isn\u2019t treated appropriately. Besides its physical effects on the skin, acne can also lead to low self-esteem and depression.<\/p>\n<p>Acne is caused by clogged, sebum-filled pores that provide a perfect environment for the growth of\u00a0bacteria. The bacteria cause infection, and the immune system responds with inflammation. Inflammation, in turn, causes swelling and redness, and may be associated with the formation of pus. If the inflammation goes deep into the skin, it may form an acne nodule.<\/p>\n<p>Mild acne often responds well to treatment with over-the-counter (OTC) products containing benzoyl peroxide or salicylic\u00a0acid. Treatment with these products may take a month or two to clear up the acne. Once the skin clears, treatment generally needs to continue for some time to prevent future breakouts.<\/p>\n<p>If acne fails to respond to OTC products, nodules develop, or acne is affecting self-esteem, a visit to a dermatologist is in order. A dermatologist can determine which treatment is best for a given patient. A dermatologist can also prescribe prescription medications (which are likely to be more effective than OTC products) and provide other medical treatments, such as laser light therapies or chemical peels.<\/p>\n<p>What can you do to maintain healthy skin and prevent or reduce acne? Dermatologists recommend the following tips:<\/p>\n<ul>\n<li>Wash affected or acne-prone skin (such as the face) twice a day, and after sweating.<\/li>\n<li>Use your fingertips to apply a gentle, non-abrasive cleanser. Avoid scrubbing, which can make acne worse.<\/li>\n<li>Use only alcohol-free products and avoid any products that irritate the skin, such as harsh astringents or exfoliants.<\/li>\n<li>Rinse with lukewarm\u00a0water, and avoid using very hot or cold water.<\/li>\n<li>Shampoo your hair regularly.<\/li>\n<li>Do not pick, pop, or squeeze acne. If you do, it will take longer to heal and is more likely to scar.<\/li>\n<li>Keep your hands off your face. Avoid touching your skin throughout the day.<\/li>\n<li>Stay out of the\u00a0sun\u00a0and tanning beds. Some acne medications make your skin very sensitive to UV light.<\/li>\n<\/ul>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">10.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2625\">dermis<\/a> is the inner and thicker of the two major layers that make up the skin. It consists mainly of a matrix of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2815\">connective tissue<\/a>s that provide strength and stretch. It also contains almost all skin structures, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3006\">sensory receptors<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2448\">blood vessel<\/a>s.<\/li>\n<li>The dermis has two layers. The upper <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2460\">papillary layer<\/a> has papillae extending upward into the epidermis and loose connective tissues. The lower <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2465\">reticular layer<\/a> has denser connective tissues and structures, such as glands and hair follicles. Glands in the dermis include eccrine and apocrine sweat glands and sebaceous glands. Hair <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2684\">follicles<\/a>\u00a0are structures where hairs originate.<\/li>\n<li>Functions of the dermis include cushioning subcutaneous tissues, regulating body temperature, sensing the environment, and excreting wastes. The dense connective tissues of the dermis provide cushioning. The dermis regulates body temperature mainly by sweating and by vasodilation or vasoconstriction. The many tactile sensory receptors in the dermis make it the main organ for the sense of touch. Wastes excreted in sweat include excess water, electrolytes, and certain metabolic wastes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">10.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is the dermis?<\/li>\n<li>Describe the basic anatomy of the dermis.<\/li>\n<li>Compare and contrast the papillary and reticular layers of the dermis.<\/li>\n<li>What causes epidermal ridges, and why can they be used to identify individuals?<\/li>\n<li>Name the two types of sweat glands in the dermis, and explain\u00a0how they differ.<\/li>\n<li>What is the function of sebaceous glands?<\/li>\n<li>Describe the structures associated with hair follicles.<\/li>\n<li>Explain how the dermis helps regulate body temperature.<\/li>\n<li>Identify three specific kinds of tactile receptors in the dermis, along with the type of stimuli they sense.<\/li>\n<li>How does the dermis excrete wastes? What waste products does it excrete?<\/li>\n<li>What are subcutaneous tissues?\u00a0Which layer of the dermis provides cushioning for subcutaneous tissues? Why does this layer provide most of the cushioning, instead of the other layer?<\/li>\n<li>For each of the functions listed below, describe which structure within the dermis carries it out.\n<ol type=\"a\">\n<li>Brings nutrients to and removes wastes from dermal and lower epidermal cells<\/li>\n<li>Causes hairs to move<\/li>\n<li>Detects painful stimuli on the skin<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">10.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE<\/p>\n<p style=\"text-align: center\">How do you get rid of acne? SciShow, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">When You Can't Scratch Away An Itch, Seeker, 2013.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 10.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Goose_bumps.jpg\" rel=\"cc:attributionURL\">Goose_bumps<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/photos\/61532128@N00\" rel=\"nofollow\">EverJean<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 10.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:506_Layers_of_the_Dermis.jpg\" rel=\"cc:attributionURL\">Layers_of_the_Dermis<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 10.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Fingerprint_detail_on_male_finger_in_T%C5%99eb%C3%AD%C4%8D,_T%C5%99eb%C3%AD%C4%8D_District.jpg\" rel=\"cc:attributionURL\">Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d,_T\u0159eb\u00ed\u010d_District<\/a> by <a title=\"User:Frettie\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Frettie\">Frettie<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong style=\"text-align: initial;font-size: 1em\">Figure 10.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0802_Skin_DermalCirculation.png\" rel=\"cc:attributionURL\">Blausen_0802_Skin_Dermal Circulation<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial;font-size: 1em\">\u00a0<a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anatomy_The_Skin_-_NCI_Visuals_Online.jpg\" rel=\"cc:attributionURL\">Anatomy_The_Skin_-_NCI_Visuals_Online<\/a>\u00a0by Don Bliss (artist) \/ \u00a0<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a class=\"extiw\" title=\"en:National Institutes of Health\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Institutes_of_Health\">National Institutes of Health<\/a>, with the ID\u00a0<a class=\"external text\" href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4604\" rel=\"nofollow\">4604<\/a>) is in the<span style=\"font-size: 1em\"> <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0809_Skin_TactileReceptors.png\" rel=\"cc:attributionURL\">Blausen_0809_Skin_TactileReceptors<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial;font-size: 1em\">\u00a0<a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Akne-jugend.jpg\" rel=\"cc:attributionURL\">Akne-jugend<\/a> by <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> <span style=\"font-size: 1em\">(https:\/\/en.wikipedia.org\/wiki\/public_domain)<\/span>. (No machine-readable author provided. <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a>\u00a0assumed, based on copyright claims).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure 5.7 Layers of the dermis [digital image]. In <em>Anatomy and Physiology<\/em> (Section 5.1 Layers of the skin). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin<\/p>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">SciShow. (2016, October 26). How do you get rid of acne? YouTube. https:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE<\/p>\n<p class=\"hanging-indent\">Seeker. (2013, October 26). When you can't scratch away an itch. YouTube. https:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;amp;feature=emb_logo<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_2936\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_2936\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<div id=\"h5p-83\">\n<div class=\"h5p-content\" data-content-id=\"83\"><\/div>\n<\/div>\n<p><em>Figure 6.3.1 How would you classify these people?\u00a0<\/em><\/p>\n<h1>Why Classify?<\/h1>\n<p>What do you see when you look at Figure 6.3.1? Did you sort individuals into categories based in gender, age, body type, facial features, skin colour or other characteristics?\u00a0 As humans, we seem to have a penchant for classifying and labeling people and things. It helps us establish a sense of order in the world around us. The 18th century taxonomist <a href=\"https:\/\/en.wikipedia.org\/wiki\/Carl_Linnaeus\" target=\"_blank\" rel=\"noopener noreferrer\">Carl Linnaeus<\/a>, for example, classified virtually all known living things into different species, genera, families, and other taxonomic categories. His classifications were based on observable phenotypic characteristics, such as skin colour. Modern biological classifications of living things are usually based on phylogenetic relationships. Phylogenies reflect evolutionary history and group together living things that are related by descent from a common ancestor.<\/p>\n<p>Starting with Linnaeus and continuing to the present, scientists and others have attempted to classify human variation. There are three basic approaches to classification: typological, populational, and clinal.<\/p>\n<div>\n<h2>Typological Approach<\/h2>\n<\/div>\n<p>The\u00a0typological approach\u00a0involves creating a\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2650\">typology<\/a><strong>,<\/strong>\u00a0which is a system of discrete types, or categories. This approach was widely used by scientists up through the early 20th century. Racial classifications are typological classifications. They place people into a small number of discrete categories, or\u00a0races<strong>,<\/strong> based on a few readily observable traits, such as skin colour, hair texture, facial features, and body build.<\/p>\n<h2>Racial Classifications and Racism<\/h2>\n<p>Racial classifications of humans probably go back as long as people distinguished \u201cus\u201d from \u201cthem.\u201d An early \u201cscientific\u201d classification of humans into races is Linnaeus\u2019 1735 classification. He divided\u00a0<em>Homo sapiens<\/em>\u00a0into continental races, which he named\u00a0<em>europaeus, asiaticus, americanus,<\/em>\u00a0and\u00a0<em>afer.<\/em> Linnaeus described these races in terms of observable physical traits. He also associated, inaccurately, each race with different personality qualities and behaviors. For example, he described <em>Homo sapiens europaeus<\/em>\u00a0as active and adventurous and\u00a0<em>Homo sapiens afer<\/em>\u00a0as lazy and careless. In 1795, the German naturalist <a href=\"https:\/\/en.wikipedia.org\/wiki\/Johann_Friedrich_Blumenbach\" target=\"_blank\" rel=\"noopener noreferrer\">Johann Friedrich Blumenbach<\/a> proposed five major races of\u00a0<em>Homo sapiens<\/em>, which he named the caucasoid, mongoloid, negroid, American Indian, and Malayan races. Blumenbach thought that the caucasoid race was the original race, and that the other races arose in a process of \u201cdegeneration\u201d from the caucasoids.<\/p>\n<figure id=\"attachment_452\" aria-describedby=\"caption-attachment-452\" style=\"width: 592px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-450\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Huxley_races.png\" alt=\"\" width=\"592\" height=\"274\"><figcaption id=\"caption-attachment-452\" class=\"wp-caption-text\"><em>Figure 6.3.2 Huxley proposed that humans were categorized into nine races, and distributed geographically as shown in this map. Each colour represents one of Huxley\u2019s proposed races. These categories included \u201cAustraloid,\u201d \u201cXanthochroi,\u201d \u201cMelanochori,\u201d \u201cNegroes,\u201d and \u201cMongoloids,\u201d and they are not used today.<\/em><\/figcaption><\/figure>\n<p>In 1870, the English biologist <a href=\"https:\/\/en.wikipedia.org\/wiki\/Thomas_Henry_Huxley\" target=\"_blank\" rel=\"noopener noreferrer\">Thomas Huxley<\/a> classified\u00a0<em>Homo sapiens<\/em> into nine races <span style=\"text-align: initial;font-size: 1em\">which were distributed geographically<\/span>. The map in Figure 6.3.2 shows how Huxley thought the races were distributed worldwide. <span style=\"text-align: initial;font-size: 1em\">Each colour represents one of Huxley\u2019s proposed races. These categories included \u201cAustraloid,\u201d \u201cXanthochroi,\u201d \u201cMelanochori,\u201d \u201cNegroes,\u201d and \u201cMongoloids,\u201d and they are not used today. <\/span>It should be noted that Huxley did not hold such strong negative stereotypes about non-European (or non-caucasoid) races as did his intellectual forebears. Huxley, however, still attributed different behaviors to racial groups that had nothing to do with the colour of their skin or continent of origin.<\/p>\n<p>By the early 20th century, so-called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2652\">scientific racism<\/a><\/strong> was a popular ideology. This was the idea that race is a biological concept and that human behavior is partly determined by race. At around 1950, in a series of groundbreaking studies of skeletal anatomy, anthropologist <a href=\"https:\/\/en.wikipedia.org\/wiki\/Franz_Boas\" target=\"_blank\" rel=\"noopener noreferrer\">Franz Boas<\/a> showed that cranial (skull) shape and size were highly malleable, depending on environmental factors (such as health and nutrition). He contrasted this with\u00a0racial anthropologists'\u00a0claims that head shape is a stable racial trait. In this way, Boas demonstrated that this commonly used racial trait was determined by the environment, and not just genes. Boas also worked to demonstrate that differences in human behavior are not determined primarily by innate biological dispositions, but are largely the result of cultural differences acquired through social learning.<\/p>\n<p>Unfortunately,\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2659\">racism<\/a><\/strong> still persists today \u2014 in society at large, if not in science. This is the association of racial traits (such as skin colour) with unrelated traits (such as intelligence), often leading to prejudice and discrimination against people based only on how they look. The concept of human race is real, not in a biological sense, but in a social sense. Racial stereotypes and racism are deeply ingrained in our history and culture, and they have real material effects on human lives.<\/p>\n<h2>Additional Problems with Typological Classification<\/h2>\n<p>Besides the problem of racism, there are other problems with typological approaches to the biological classification of\u00a0<em>Homo sapiens.<\/em>\u00a0One problem is that most human biological traits are not either present or absent, but instead vary on a continuum. This type of distribution cannot be adequately represented by discrete categories, such as races. The typological approach also results in groupings of people that may be similar in terms of some traits, but not others. How people are grouped together depends on which traits are chosen. In addition, the number of groups that are needed to classify people depends on the number of traits that are used. The greater the number of traits, the greater the number of racial categories there must be. If racial categories depend on the traits chosen to define them, it is clear that the racial classifications are arbitrary and do not reflect biological reality.<\/p>\n<p>Another problem with typological classifications is that they lead to the mistaken belief that people within typological categories are more similar to each other than they are to people in other categories. There is actually more variation\u00a0<em>within<\/em>\u00a0than\u00a0<em>between<\/em> typological groups. An estimated 90 per cent of human genetic variation occurs between people within races, and only 10 per cent occurs between races. Clearly, races are far from homogenous in terms of their genetic composition. In short, we are all more alike than we are different.<\/p>\n<div>\n<h1>Populational Approach<\/h1>\n<\/div>\n<p>By the middle of the 20th century, scientists started advocating a\u00a0<strong>populational approach<\/strong>\u00a0to classifying\u00a0<em>Homo sapiens.<\/em>\u00a0This approach is based on the idea that the breeding population is the only biologically meaningful group. The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2556\">breeding population<\/a><\/strong>\u00a0is the unit of evolution, and it includes people who have mated and produced offspring together for many generations. As a result, members of the same breeding population should share many genetic traits. You would also expect them to have many of the same phenotypic traits, because of their similar genetic makeup.<\/p>\n<p>While the populational approach makes sense in theory, in reality, it can rarely be applied, because most human populations are not closed breeding populations. Some people have always selected mates from outside their local population (even mating with archaic humans such as Neanderthals). This tendency has increased dramatically in recent centuries with the advent of efficient means of traveling long distances. As a consequence, there are very few remaining distinct breeding populations within the human species.<\/p>\n<figure id=\"attachment_452\" aria-describedby=\"caption-attachment-452\" style=\"width: 437px\" class=\"wp-caption alignright\"><img class=\" wp-image-451\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nicobar_Islands.png\" alt=\"Nicobar_Islands\" width=\"437\" height=\"299\"><figcaption id=\"caption-attachment-452\" class=\"wp-caption-text\"><em>Figure 6.3.3 The Andaman Islands are boxed in red on this map of South and Southeast Asia.<\/em><\/figcaption><\/figure>\n<p>An example of one such population is the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Sentinelese\" target=\"_blank\" rel=\"noopener noreferrer\">Sentinelese<\/a>, a small population of hunter-gatherers who live alone on a small island in the Andaman Islands (see the map). The Sentinelese are thought to be direct descendants of the first modern humans to leave Africa, and they may have lived in the Andaman Islands for as long as 60 thousand years. The Sentinelese are also one of the most isolated human populations on Earth. The fact that their language is distinctly different from other Andaman Islands languages is evidence that they have had little contact with other people for thousands of years. Although closed breeding populations (such as the Sentinelese) may be useful for investigating questions about evolutionary processes, they are not useful for classifying most of humanity.<\/p>\n<p>&nbsp;<\/p>\n<div>\n<p><span style=\"font-size: 1.424em\">Clinal Approach<\/span><\/p>\n<\/div>\n<p>By the 1960s, scientists began to use a\u00a0<strong>clinal approach<\/strong>\u00a0to classify human variation. This approach maps variation in traits over geographic regions (such as continents) or even worldwide. Clinal models are a useful way of describing human variation that does not lead to discrete races or other categories of people.<\/p>\n<figure id=\"attachment_452\" aria-describedby=\"caption-attachment-452\" style=\"width: 516px\" class=\"wp-caption alignleft\"><img class=\"wp-image-452 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Map_of_Group_O.png\" alt=\"\" width=\"516\" height=\"284\"><figcaption id=\"caption-attachment-452\" class=\"wp-caption-text\"><em>Figure 6.3.4 Distribution of Type O Blood in Indigenous Populations of the World.<\/em><\/figcaption><\/figure>\n<p>In Figure 6.3.4 you can see a worldwide clinal map for type O blood in the human ABO blood group system. The frequency of this trait is shown for the indigenous populations of various regions. It is lowest throughout Asia and highest in Native American populations in both North and South America. This geographic distribution results from the complex interaction of a variety of factors, including natural selection, genetic drift, and gene flow. You can read more about geographic variation in blood types in the concept <em>Variation in Blood Types.<\/em><\/p>\n<div>\n<p><span style=\"text-align: initial;font-size: 1em\">Clinal maps for many genetic traits show variation that changes gradually from one geographic area to another, which may happen because of the nature of gene flow. Gene flow occurs when mating takes place between people in different populations. The likelihood of mating with others depends on their distance from us. You may not marry the boy or girl next door, but your mate is more likely to be someone in the same state or country than someone on another continent.<\/span><\/p>\n<\/div>\n<p>Natural selection has a major impact on the clinal distribution of some traits, because variation in the traits tracks variation in selective pressures. For example, the environmental stressor of malaria varies throughout Africa with climate, as you can see in the left-hand map below (Figure 6.3.5). The sickle cell trait that protects from malaria has a similar distribution, as shown in the right-hand map.<\/p>\n<div id=\"h5p-84\">\n<div class=\"h5p-content\" data-content-id=\"84\"><\/div>\n<\/div>\n<p><em>Figure 6.3.5\u00a0<\/em><\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.3 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Humans seem to have a need to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2595\">classify<\/a> and label people based on their similarities and differences. Three approaches to classifying human variation include typological, populational, and clinal approaches.<\/li>\n<li>The typological approach involves creating a typology, which is a system of discrete categories, or races. This approach was widely used by scientists until the early 20th century. Racial categories are based on observable phenotypic traits (such as skin colour), but other traits and behaviors are often assumed to apply to racial groups, as well. The use of racial classifications often leads to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2659\">racism<\/a>.<\/li>\n<li>By the mid-20th century, scientists started advocating a population approach. This assumes that the breeding population, which is the unit of evolution, is the only biologically meaningful group. While this approach makes sense in theory, in reality, it can rarely be applied to actual human populations. With few exceptions, most human populations are not closed breeding populations.<\/li>\n<li>By the 1960s, scientists began to use a clinal approach to classify human variation. This approach maps variation in the frequency of traits or alleles over geographic regions or worldwide. Clinal maps for many genetic traits show variation that changes gradually from one geographic area to another. This type of distribution may result from gene flow and\/or natural selection.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li style=\"margin-top: 0px\">Name the 18th century taxonomist that classified virtually all known living things.<\/li>\n<li>Describe the typological approach to classifying human variation.<\/li>\n<li>Discuss why typological classifications of <em>Homo sapiens <\/em>are associated with racism.<\/li>\n<li>Why is the breeding population considered to be the most meaningful biological group?<\/li>\n<li>Explain why it is generally unrealistic to apply a populational approach to classifying the human species.<\/li>\n<li>What does a clinal map show?<\/li>\n<li>Explain how gene flow and natural selection can result in a gradual change in the frequency of a trait over geographic space.<\/li>\n<li>Most human traits vary on a continuum. Explain why this presents a problem for the typological classification approach.<\/li>\n<li>\n<div id=\"h5p-85\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-85\" class=\"h5p-iframe\" data-content-id=\"85\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Classifying Human Variation\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.3 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=ntimKsWDUpA&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">The Biology of Race in the Absence of Biological Races,<br \/>\nCentre for Genetic Medicine, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=QOSPNVunyFQ<\/p>\n<p style=\"text-align: center\">Nina Jablonski breaks the illusion of skin color, TED, 2009.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=_r4c2NT4naQ<\/p>\n<p style=\"text-align: center\">The science of skin color - Angela Koine Flynn, TED-Ed, 2016.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 6.3.1<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/unsplash.com\/photos\/gYdjZzXNWlg\">Three women sitting by flowers and laughing<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@priscilladupreez\">Priscilla Du Preez<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/qjHtxArSBT8\">Two women sitting on sofa<\/a> by <a href=\"https:\/\/unsplash.com\/@canweallgo\">AllGo<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/-Xv7k95vOFA\">Young people in conversation<\/a> by <a href=\"https:\/\/unsplash.com\/@alexisrbrown\">Alexis Brown<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/zimQNLdnKp0\">Men talking in the cold<\/a> by <a href=\"https:\/\/unsplash.com\/@ann_van_\">Anna Vander Stel<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/-8UEuVWA-Tk\">Laughing by the tracks<\/a> by <a href=\"https:\/\/unsplash.com\/@priscilladupreez\">Priscilla Du Preez<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<\/ul>\n<p><strong>Figure 6.3.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Huxley_races.png\" rel=\"cc:attributionURL\">Huxley_races<\/a> by <a title=\"User:Wobble\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Wobble\">Wobble<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 6.3.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Nicobar_Islands.PNG\" rel=\"cc:attributionURL\">Nicobar_Islands<\/a> is edited by <a href=\"https:\/\/nl.wikipedia.org\/wiki\/Gebruiker:Michiel1972\">M.Minderhoud<\/a> on Wikimedia Commons, and was released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> by its original author, <a class=\"external text\" href=\"http:\/\/www.demis.nl\/\" rel=\"nofollow\">www.demis.nl<\/a>. (<i>See also\u00a0<a class=\"extiw\" title=\"de:Bild:Demis Best\u00e4tigung.gif\" href=\"https:\/\/de.wikipedia.org\/wiki\/Bild:Demis_Best%C3%A4tigung.gif\">approval email on de.wp<\/a>\u00a0and\u00a0<a title=\"Template talk:PD-Demis\" href=\"https:\/\/commons.wikimedia.org\/wiki\/Template_talk:PD-Demis\">its clarification<\/a>.)<\/i><\/p>\n<p><strong>Figure 6.3.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Map_of_Group_O.png\">Map_of_Group_O<\/a>\/ (Percent of Native population that has the O blood type) by <a class=\"new mw-userlink\" title=\"User:Ephert (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Ephert&amp;action=edit&amp;redlink=1\">Ephert<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license. (Original <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Mapa_del_grupo_O.GIF\">Spanish edition<\/a> by\u00a0<a title=\"User:Maulucioni\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Maulucioni\">Maulucioni)<\/a><\/p>\n<p><strong>Figure 6.3.5<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Malaria_distribution.jpg\">Malaria distribution<\/a> by <a class=\"extiw\" title=\"wikipedia:User:Muntuwandi\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Muntuwandi\">Muntuwandi<\/a>\u00a0at\u00a0<a class=\"extiw\" title=\"wikipedia:\" href=\"https:\/\/en.wikipedia.org\/wiki\/\">English Wikipedia<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Sickle_cell_distribution.jpg\">Sickle cell distribution<\/a> by <a class=\"extiw\" title=\"wikipedia:User:Muntuwandi\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Muntuwandi\">Muntuwandi<\/a>\u00a0at\u00a0<a class=\"extiw\" title=\"wikipedia:\" href=\"https:\/\/en.wikipedia.org\/wiki\/\">English Wikipedia<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en) license.<\/li>\n<\/ul>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span style=\"text-align: initial;font-size: 1em\">Centre for Genetic Medicine. (2015, July 14). The biology of race in the absence of biological races. YouTube. https:\/\/www.youtube.com\/watch?v=ntimKsWDUpA&amp;feature=youtu.be<\/span><\/p>\n<p class=\"hanging-indent\">TED. (2009, August 7). Nina Jablonski breaks the illusion of skin color. YouTube. https:\/\/www.youtube.com\/watch?v=QOSPNVunyFQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2016, February 16). The science of skin color - Angela Koine Flynn. YouTube. https:\/\/www.youtube.com\/watch?v=_r4c2NT4naQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 27). Carl Linnaeus. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Carl_Linnaeus&amp;oldid=964690855<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, May 18). Franz Boas. In <em>Wikipedia<\/em>. https:\/\/en.wikipedia.org\/w\/index.php?title=Franz_Boas&amp;oldid=957282443<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, July 5). Johann Friedrich Blumenbach. In <em>Wikipedia<\/em>.\u00a0 https:\/\/en.wikipedia.org\/w\/index.php?title=Johann_Friedrich_Blumenbach&amp;oldid=966196943<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, July 11). Sentinelese. In <em>Wikipedia<\/em>. https:\/\/en.wikipedia.org\/w\/index.php?title=Sentinelese&amp;oldid=967121254<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, July 14). Thomas Henry Huxley. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Thomas_Henry_Huxley&amp;oldid=967701553<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5843\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5843\"><div tabindex=\"-1\"><p>The upper layer of the dermis with papillae extending upward into the epidermis.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5907\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5907\"><div tabindex=\"-1\"><p>A thin, fibrous, extracellular matrix that separates the lining of an internal or external body surface from underlying connective tissue.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5847\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5847\"><div tabindex=\"-1\"><p>The lower layer of the dermis that gives the dermis strength and elasticity and contains many dermal structures such as glands and hair follicles.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_6015\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_6015\"><div tabindex=\"-1\"><p>An anatomical structure that consists of a small cluster of cells, surrounding a central cavity.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3006\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3006\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4487\" aria-describedby=\"caption-attachment-4487\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4487\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/vampire_PNG32-1.png\" alt=\"14.5.1\" width=\"400\" height=\"316\"><figcaption id=\"caption-attachment-4487\" class=\"wp-caption-text\"><em>Figure 14.5.1 \"I want to suck your blood.\"<\/em><\/figcaption><\/figure>\n<div>\n<h1>Vampires<\/h1>\n<\/div>\n<p>From Bram Stoker\u2019s famous novel about Count Dracula, to films such as <em>Van Helsing<\/em> and the <em>Twilight<\/em> Saga<em>,<\/em> fantasies featuring vampires (like the one in Figure 14.5.1) have been popular for decades. Vampires, in fact, are found in centuries-old myths from many cultures. In such myths, vampires are generally described as creatures that drink blood \u2014 preferably of the human variety \u2014 for sustenance. Dracula, for example, is based on Eastern European folklore about a human who attains immortality (and eternal damnation) by drinking the blood of others.<\/p>\n<div>\n<h1>What Is Blood?<\/h1>\n<\/div>\n<figure id=\"attachment_4489\" aria-describedby=\"caption-attachment-4489\" style=\"width: 397px\" class=\"wp-caption alignleft\"><img class=\"wp-image-4489 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blood-centrifugation-scheme-1.png\" alt=\"14.5.2 Components of Blood\" width=\"397\" height=\"530\"><figcaption id=\"caption-attachment-4489\" class=\"wp-caption-text\">Figure 14.5.2 If blood is centrifuged (spun at high speed), it separates into its major components based on density, as shown here: plasma, leukocytes (white blood cells) and platelets, and erythrocytes (red blood cells). All blood normally contains these components in about the same proportions.<\/figcaption><\/figure>\n<p>The average adult body contains between 4.7 and 5.7 litres of blood. More than half of that amount is fluid. Most of the rest of that amount consists of blood cells. The relative amounts of the various components in blood are illustrated in Figure 14.5.2. The components are also described in detail below.<\/p>\n<div>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2702\"><strong>Blood<\/strong><\/a><span style=\"text-align: initial;font-size: 1em\">\u00a0is a fluid connective tissue that circulates throughout the body through blood vessels of the cardiovascular system. What makes blood so special that it features in widespread myths? Although blood accounts for less than 10% of human body weight, it is quite literally the elixir of life. As blood travels through the vessels of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3835\">cardiovascular system<\/a>, it delivers vital substances (such as nutrients and oxygen) to all of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3573\">cells<\/a>, and carries away their metabolic wastes. It is no exaggeration to say that without blood, cells could not survive. Indeed, without the oxygen carried in blood, cells of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3823\">brain<\/a> start to die within a matter of minutes.<\/span><\/p>\n<h1>Functions of Blood<\/h1>\n<\/div>\n<p>Blood performs many important functions in the body. Major functions of blood include:<\/p>\n<ul>\n<li>Supplying tissues with oxygen, which is needed by all cells for <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3785\">aerobic cellular respiration<\/a>.<\/li>\n<li>Supplying cells with nutrients, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3359\">glucose<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3615\">amino acids<\/a>, and fatty acids.<\/li>\n<li>Removing metabolic wastes from cells, including carbon dioxide, urea, and lactic acid.<\/li>\n<li>Helping to defend the body from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3707\">pathogens<\/a> and other foreign substances.<\/li>\n<li>Forming clots to seal broken blood vessels and stop bleeding.<\/li>\n<li>Transporting <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3569\">hormones<\/a> and other messenger molecules.<\/li>\n<li>Regulating the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4330\">pH<\/a> of the body, which must be kept within a narrow range (7.35 to 7.45).<\/li>\n<li>Helping regulate body temperature (through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3942\">vasoconstriction<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2756\">vasodilation<\/a>).<\/li>\n<\/ul>\n<div>\n<h1>Blood\u00a0Plasma<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4395\">Plasma<\/a><\/strong> is the liquid component of human blood. It makes up about 55% of blood by volume. It is about 92% water, and contains many dissolved substances. Most of these substances are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3721\">protein<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">, but plasma also contains trace amounts of glucose, mineral ions, hormones, carbon dioxide, and other substances. In addition, plasma contains blood cells. When the cells are removed from plasma, as in Figure 14.5.2 above, the remaining liquid is clear but yellow in colour.<\/span><\/p>\n<div>\n<h1>Blood Cells<\/h1>\n<\/div>\n<p>The cells in blood include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4398\">erythrocytes<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3531\">leukocytes<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4399\">thrombocytes<\/a>. These different types of blood cells are shown in the photomicrograph (Figure 14.5.3) and described in the sections that follow.<\/p>\n<figure id=\"attachment_4490\" aria-describedby=\"caption-attachment-4490\" style=\"width: 402px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4490\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/SEM_blood_cells-1.jpg\" alt=\"14.5.3 SEM Blood Cells\" width=\"402\" height=\"500\"><figcaption id=\"caption-attachment-4490\" class=\"wp-caption-text\"><em>Figure 14.5.3 Highly magnified blood cells in this image include doughnut-shaped red blood cells, rough-surfaced white blood cells, and small disc-shaped platelets.<\/em><\/figcaption><\/figure>\n<h2>Erythrocytes<\/h2>\n<p>The most numerous cells in blood are\u00a0red blood cells<strong>,<\/strong>\u00a0also called <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4398\">erythrocyte<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">. One microlitre of blood contains between 4.2 and 6.1 million red blood cells, and red blood cells make up about 25% of all the cells in the human body. The cytoplasm of a mature erythrocyte is almost completely filled with hemoglobin, the iron-containing protein that binds with oxygen and gives the cell its red colour. In order to provide maximum space for hemoglobin, mature erythrocytes lack a cell <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3705\">nucleus<\/a> and most <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3465\">organelle<\/span><span style=\"font-size: 1em\">s<\/span><span style=\"font-size: 1em;text-align: initial\"><\/a><\/span><span style=\"font-size: 1em;text-align: initial\">. They are little more than sacks of hemoglobin.<\/span><\/p>\n<p>Erythrocytes also carry proteins called antigens that determine blood type. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2703\">Blood type<\/a> is a genetic characteristic. The best known human blood type systems are the ABO and Rhesus systems.<\/p>\n<ul>\n<li>In the ABO system, there are two common antigens, called antigen A and antigen B. There are four ABO blood types, A (only A antigen), B (only B antigen), AB (both A and B antigens), and O (neither A nor B antigen). The ABO antigens are illustrated in Figure 14.5.4.<\/li>\n<li>In the Rhesus system, there is just one common antigen. A person may either have the antigen (Rh+) or lack the antigen (Rh-).<\/li>\n<\/ul>\n<figure id=\"attachment_4491\" aria-describedby=\"caption-attachment-4491\" style=\"width: 856px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4491\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/ABO_blood_type.svg_-1-2.png\" alt=\"14.5.4 ABO Blood Group\" width=\"856\" height=\"550\"><figcaption id=\"caption-attachment-4491\" class=\"wp-caption-text\"><em>Figure 14.5.4 Each of the ABO blood types is characterized by different glycoproteins on red blood cells.<\/em><\/figcaption><\/figure>\n<p>Blood type\u00a0is important for medical reasons. A person who needs a blood transfusion must receive blood of a compatible type. Blood that is compatible lacks antigens that the patient's own blood also lacks. For example, for a person with type A blood (no B antigen), compatible types include any type of blood that lacks the B antigen. This would include type A blood or type O blood, but not type AB or type B blood. If incompatible blood is transfused, it may cause a potentially life-threatening reaction in the patient\u2019s blood.<\/p>\n<h2>Leukocytes<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3531\">Leukocyte<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0(also called white blood cells)<\/span><span style=\"text-align: initial;font-size: 1em\"> are cells in blood that defend the body against invading microorganisms and other threats. There are far fewer leukocytes than red blood cells in blood. There are normally only about 1,000 to 11,000 white blood cells per microlitre of blood. Unlike erythrocytes, leukocytes have a nucleus. White blood cells are part of the body\u2019s immune system. They destroy and remove old or abnormal cells and cellular debris, as well as attack pathogens and foreign substances. There are five main types of white blood cells, which are described in Table 14.5.1: neutrophils, eosinophils, basophils, lymphocytes, and monocytes. The five types differ in their specific immune functions.<\/span><\/p>\n<table class=\"grid\" style=\"width: 100%;height: 159px\">\n<caption>Table 14.5.1: Major Types of White Blood Cells<\/caption>\n<tbody>\n<tr style=\"height: 59px\">\n<th scope=\"col\">Type of Leukocyte<\/th>\n<th scope=\"col\">Per cent of All Leukocytes<\/th>\n<th scope=\"col\">Main Function(s)<\/th>\n<\/tr>\n<tr style=\"height: 14px\">\n<td>Neutrophil<\/td>\n<td>62%<\/td>\n<td>Phagocytize (engulf and destroy) bacteria and fungi in blood.<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td>Eosinophil<\/td>\n<td>\u00a0 2%<\/td>\n<td>Attack and kill large parasites; carry out allergic responses.<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td>Basophil<\/td>\n<td>\u00a0less than 1%<\/td>\n<td>Release histamines in inflammatory responses.<\/td>\n<\/tr>\n<tr style=\"height: 30px\">\n<td>Lymphocyte<\/td>\n<td>30%<\/td>\n<td>Attack and destroy virus-infected and tumor cells; create lasting immunity to specific pathogens.<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td>Monocyte<\/td>\n<td>\u00a0 5%<\/td>\n<td>Phagocytize pathogens and debris in tissues.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Thrombocytes<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4399\">Thrombocyte<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a>,<\/strong><span style=\"text-align: initial;font-size: 1em\"> also called platelets, are actually cell fragments. Like erythrocytes, they lack a nucleus and are more numerous than white blood cells. There are about 150 thousand to 400 thousand thrombocytes per microlitre of blood.<\/span><\/p>\n<p>The main function of thrombocytes is blood clotting, or <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4492\">coagulation<\/a>.<\/strong>\u00a0This is the process by which blood changes from a\u00a0liquid\u00a0to a gel, forming a plug in a damaged blood vessel. If blood clotting is successful, it results in\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4493\">hemostasis<\/a><\/strong>, which is the cessation of blood loss from the damaged vessel. A blood clot consists of both platelets and proteins, especially the protein fibrin. You can see a scanning electron microscope photomicrograph of a blood clot in Figure 14.5.5.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_4494\" aria-describedby=\"caption-attachment-4494\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4494\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blood_clot_in_scanning_electron_microscopy-1.jpg\" alt=\"14.5.5 Blood Clot\" width=\"400\" height=\"271\"><figcaption id=\"caption-attachment-4494\" class=\"wp-caption-text\"><em>Figure 14.5.5 Erythrocytes become trapped in a coagulating clot so they cannot escape through a break in a blood vessel.<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_4496\" aria-describedby=\"caption-attachment-4496\" style=\"width: 311px\" class=\"wp-caption alignleft\"><img class=\" wp-image-4496\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0740_Platelets-1.png\" alt=\"14.5.6 Activated Thrombocytes\" width=\"311\" height=\"311\"><figcaption id=\"caption-attachment-4496\" class=\"wp-caption-text\"><em>Figure 14.5.6 The shape of platelets (thrombocytes) after they are activated helps them to stick together and form a plug for a damaged blood vessel.<\/em><\/figcaption><\/figure>\n<p>Coagulation begins almost instantly after an injury occurs to the endothelium of a blood vessel. Thrombocytes become activated and change their shape from spherical to star-shaped, as shown in Figure 14.5.6. This helps them aggregate with one another (stick together) at the site of injury to start forming a plug in the vessel wall. Activated thrombocytes also release substances into the blood that activate additional thrombocytes and start a sequence of reactions leading to fibrin formation. Strands of fibrin crisscross the platelet plug and strengthen it, much as rebar strengthens concrete.<\/p>\n<figure id=\"attachment_4651\" aria-describedby=\"caption-attachment-4651\" style=\"width: 675px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4651\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Platelet_Party_900x-1.png\" alt=\"Platelet Party\" width=\"675\" height=\"821\"><figcaption id=\"caption-attachment-4651\" class=\"wp-caption-text\"><em>Figure 14.5.7 Image by Nick Seluk\/ <a href=\"http:\/\/theAwkwardYeti.com\">theAwkwardYeti.com<\/a>. (c) Used with permission.<\/em><\/figcaption><\/figure>\n<h2>Formation and Degradation of Blood Cells<\/h2>\n<p>Blood is considered a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2815\">connective tissue<\/a>, because blood cells form inside\u00a0bones. All three types of blood cells are made in red marrow within the medullary cavity of bones in a process called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3961\">hematopoiesis<\/a><\/strong>. Formation of blood cells occurs by the proliferation of stem cells in the marrow. These stem cells are self-renewing \u2014 when they divide, some of the daughter cells remain stem cells, so the pool of stem cells is not used up. Other daughter cells follow various pathways to differentiate into the variety of blood cell types. Once the cells have differentiated, they cannot divide to form copies of themselves.<\/p>\n<p>Eventually, blood cells die and must be replaced through the formation of new blood cells from proliferating stem cells. After blood cells die, the dead cells are phagocytized (engulfed and destroyed) by white blood cells, and removed from the\u00a0circulation. This process most often takes place in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4497\">spleen<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2989\">liver<\/a>.<\/p>\n<div>\n<h1>Blood Disorders<\/h1>\n<\/div>\n<p>Many human disorders primarily affect the blood. They include cancers,\u00a0genetic disorders, poisoning by toxins, infections, and nutritional deficiencies.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4498\">Leukemia<\/a><\/strong> is a group of cancers of the blood-forming tissues in the bone marrow. It is the most common type of cancer in children, although most cases occur in adults. Leukemia is generally characterized by large numbers of abnormal leukocytes. Symptoms may include excessive bleeding and bruising, fatigue, fever, and an increased risk of infections. Leukemia is thought to be caused by a combination of genetic and environmental factors.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4499\">Hemophilia<\/a><\/strong>\u00a0refers to any of several\u00a0genetic disorders\u00a0that cause dysfunction in the blood clotting process. People with hemophilia are prone to potentially uncontrollable bleeding, even with otherwise inconsequential injuries. They also commonly suffer bleeding into the spaces between\u00a0joints, which can cause crippling.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4500\">Carbon monoxide poisoning<\/a><\/strong> occurs when inhaled carbon monoxide (in fumes from a faulty home furnace or car exhaust, for example) binds irreversibly to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3556\">hemoglobin<\/a> in erythrocytes. As a result, oxygen cannot bind to the red blood cells for transport throughout the body, and this can quickly lead to suffocation. Carbon monoxide is extremely dangerous, because it is colourless and odorless, so it cannot be detected in the air by human senses.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4501\">HIV<\/a><\/strong> is a virus that infects certain types of leukocytes and interferes with the body\u2019s ability to defend itself from pathogens and other causes of illness. HIV infection may eventually lead to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3523\">AIDS<\/a> (acquired immunodeficiency syndrome). AIDS is characterized by rare infections and cancers that people with a healthy immune system almost never acquire.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3449\">Anemia<\/a><\/strong> is a disorder in which the blood has an inadequate volume of erythrocytes, reducing the amount of oxygen that the blood can carry, and potentially causing weakness and fatigue. These and other signs and symptoms of anemia are shown in Figure 14.5.8. Anemia has many possible causes, including excessive bleeding, inherited disorders (such as sickle cell hemoglobin), or nutritional deficiencies (iron, folate, or B12). Severe anemia may require transfusions of donated blood.<\/li>\n<\/ul>\n<figure id=\"attachment_4502\" aria-describedby=\"caption-attachment-4502\" style=\"width: 623px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4502\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Symptoms_of_anemia.svg_-1.png\" alt=\"14.5.7 Symptoms of Anemia\" width=\"623\" height=\"587\"><figcaption id=\"caption-attachment-4502\" class=\"wp-caption-text\"><em>Figure 14.5.8 Anemia has wide-ranging effects on the human body because oxygen is essential for normal functioning of cells in every organ system.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Feature: Myth vs. Reality<\/h1>\n<\/div>\n<p>Donating blood saves lives. In fact, with each blood donation, as many as <em>three<\/em> lives may be saved. According to Government Canada, up to 52% of Canadians have reported that they or a family member have needed blood or blood products at some point in their lifetime. Many donors agree that the\u00a0feeling that comes from knowing you have saved lives is well worth the short amount of time it takes to make a blood donation. Nonetheless, only a minority of potential donors actually donate blood. There are many myths about blood donation that may help explain the small percentage of donors. Knowing the facts may reaffirm your decision to donate if you are already a donor \u2014 and if you aren\u2019t a donor already, getting the facts may help you decide to become one.<\/p>\n<table class=\"grid\" style=\"border-collapse: collapse;width: 100%;height: 347px\" border=\"0\">\n<tbody>\n<tr>\n<th scope=\"col\"><span style=\"color: #ff0000\">Myth<\/span><\/th>\n<th scope=\"col\"><span style=\"color: #008000\">Reality<\/span><\/th>\n<\/tr>\n<tr style=\"height: 47px\">\n<td>\"Your blood might become contaminated with an infection during the donation.\"<\/td>\n<td>There is no risk of contamination because only single-use, disposable catheters, tubing, and other equipment are used to collect blood for a donation.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"You are too old (or too young) to donate blood.\"<\/td>\n<td>There is no upper age limit on donating blood, as long as you are healthy. The minimum age\u00a0is 16 years.<\/td>\n<\/tr>\n<tr style=\"height: 47px\">\n<td>\"You can\u2019t donate blood if you have high blood pressure.\"<\/td>\n<td>As long as your\u00a0blood pressure\u00a0is below 180\/100 at the time of donation, you can give blood. Even if you take blood pressure medication to keep your blood pressure below this level, you can donate.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"You can\u2019t give blood if you have high cholesterol.\"<\/td>\n<td>Having high cholesterol does not affect your ability to donate blood. Taking cholesterol-lowering medication also does not disqualify you.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"You can\u2019t donate blood if you have had a flu shot.\"<\/td>\n<td>Having a flu shot has no effect on your ability to donate blood. You can even donate on the same day that you receive a flu shot.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"You can\u2019t donate blood if you take medication.\"<\/td>\n<td>As long as you are healthy, in most cases, taking medication does not preclude you from donating blood.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"Your blood isn\u2019t needed if it\u2019s a common blood type.\"<\/td>\n<td>All types of blood are in constant demand.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">14.5 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2702\">Blood<\/a> is a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4402\">fluid connective tissue<\/a> that circulates throughout the body in the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3835\">cardiovascular system<\/a>. Blood supplies tissues with oxygen and\u00a0nutrients\u00a0and removes their metabolic wastes. Blood helps defend the body from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3707\">pathogens<\/a>\u00a0and other threats, transports <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3569\">hormones<\/a> and other substances, and helps keep the body\u2019s <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4330\">pH<\/a> and temperature in homeostasis.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4395\">Plasma<\/a> is the liquid component of blood, and it makes up more than half of blood by volume. It consists of water and many dissolved substances. It also contains blood cells, including erythrocytes, leukocytes and thrombocytes.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4398\">Erythrocytes<\/a>, (also known as red blood cells) are the most numerous cells in blood. They consist mostly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3556\">hemoglobin<\/a>, which carries oxygen. Erythrocytes also carry <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2704\">antigens<\/a>\u00a0that determine <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2703\">blood type<\/a>.<\/li>\n<li>Leukocytes (also referred to as white blood cells) are less numerous than erythrocytes and are part of the body\u2019s immune system. There are several different types of leukocytes that differ in their specific immune functions. They protect the body from abnormal cells, microorganisms, and other harmful substances.<\/li>\n<li>Thrombocytes (also called platelets) are cell fragments that play important roles in blood clotting, or coagulation. They stick together at breaks in blood vessels to form a clot and stimulate the production of fibrin, which strengthens the clot.<\/li>\n<li>All blood cells form by proliferation of stem cells in red bone marrow in a process called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3961\">hematopoiesis<\/a>. When blood cells die, they are phagocytized by leukocytes and removed from the circulation.<\/li>\n<li>Disorders of the blood include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4498\">leukemia<\/a>, which is\u00a0cancer\u00a0of the bone-forming cells; <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4499\">hemophilia<\/a>, which is any of several genetic blood-clotting disorders; <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4500\">carbon monoxide poisoning<\/a>, which prevents erythrocytes from binding with oxygen and causes suffocation; <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4501\">HIV<\/a> infection, which destroys certain types of leukocytes and can cause <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3523\">AIDS<\/a>; and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3449\">anemia<\/a>, in which there are not enough erythrocytes to carry adequate oxygen to body tissues.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">14.5 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is blood? Why is blood considered a connective tissue?<\/li>\n<li>Identify four physiological roles of blood in the body.<\/li>\n<li>Describe plasma and its components.<\/li>\n<li>\n<div id=\"h5p-398\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-398\" class=\"h5p-iframe\" data-content-id=\"398\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"14.5 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">14.5 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/e-5wqwp64MM<\/p>\n<p style=\"text-align: center\">Joe Landolina: This gel can make you stop bleeding instantly, TED, 2014.<\/p>\n<p>https:\/\/youtu.be\/hgp8LtwFSBA<\/p>\n<p style=\"text-align: center\">Can Synthetic Blood Help The World's Blood Shortage? Science Plus, 2016.<\/p>\n<p>https:\/\/youtu.be\/1Qfmkd6C8u8<\/p>\n<p style=\"text-align: center\">How bones make blood - Melody Smith, TED-Ed, 2020.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 14.5.1<\/strong><\/p>\n<p><a href=\"http:\/\/pngimg.com\/download\/35873\" rel=\"cc:attributionURL\">vampire_PNG32<\/a> from <a href=\"http:\/\/pngimg.com\">pngimg.com<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\" rel=\"license\">CC BY-NC 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) license.<\/p>\n<p><strong>Figure 14.5.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blood-centrifugation-scheme.png\" rel=\"cc:attributionURL\">Blood-centrifugation-scheme<\/a> by <a class=\"extiw\" title=\"wikipedia:User:KnuteKnudsen\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:KnuteKnudsen\">KnuteKnudsen<\/a>\u00a0at\u00a0<a class=\"extiw\" title=\"wikipedia:\" href=\"https:\/\/en.wikipedia.org\/wiki\/\">English Wikipedia<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 14.5.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:SEM_blood_cells.jpg\" rel=\"cc:attributionURL\">SEM_blood_cells<\/a> by Bruce Wetzel and Harry Schaefer (Photographers)\/ <a href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=2129\">NCI AV-8202-3656<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/en:Public_domain).<\/p>\n<p><strong>Figure 14.5.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:ABO_blood_type.svg\" rel=\"cc:attributionURL\">ABO_blood_type.svg<\/a> by <a class=\"new\" title=\"User:InvictaHOG (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:InvictaHOG&amp;action=edit&amp;redlink=1\">InvictaHOG<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/en:Public_domain).<\/p>\n<p><strong>Figure 14.5.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blood_clot_in_scanning_electron_microscopy.jpg\" rel=\"cc:attributionURL\">Blood_clot_in_scanning_electron_microscopy<\/a> by Janice Carr from CDC\/ Public Health Image LIbrary <a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=7308\">(PHIL) ID #7308<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/en:Public_domain).<\/p>\n<p><strong>Figure 14.5.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0740_Platelets.png\" rel=\"cc:attributionURL\">Blausen_0740_Platelets<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> <span style=\"text-align: initial;font-size: 1em\">on Wikimedia Commons is used under a <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong><br \/>\nFigure 14.5.7<\/strong><\/p>\n<p><a href=\"https:\/\/theawkwardstore.com\/products\/platelet-party-id-badge-reel\" rel=\"cc:attributionURL\">Platelet_Party_900x<\/a>\u00a0by Awkward Yeti (used with permission of the author) \u00a9\u00a0<a href=\"https:\/\/choosealicense.com\/no-license\/\" rel=\"license\">All Rights Reserved<\/a><\/p>\n<p><strong>Figure 14.5.8<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Symptoms_of_anemia.svg\" rel=\"cc:attributionURL\">Symptoms_of_anemia.svg<\/a> by <a class=\"extiw\" title=\"en:User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/en:public_domain).<\/p>\n<p><span style=\"font-size: 1.424em;font-weight: bold\"><br \/>\nReferences<\/span><\/p>\n<p class=\"hanging-indent\">Blausen.com Staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">Blood, organ and tissue donation. (2020, April 28). Government of Canada. https:\/\/www.canada.ca\/en\/public-health\/services\/healthy-living\/blood-organ-tissue-donation.html#a3<\/p>\n<p class=\"hanging-indent\">Canadian Blood Services. (n.d.). There is an immediate need for blood as demand is rising. https:\/\/www.blood.ca<\/p>\n<p class=\"hanging-indent\"><span style=\"text-align: initial;font-size: 1em\">Science Plus. (2016, March 2). Can synthetic blood help the world's blood shortage? <\/span><span style=\"text-align: initial;font-size: 1em\">https:\/\/www.youtube.com\/watch?v=hgp8LtwFSBA&amp;feature=youtu.be<\/span><\/p>\n<p class=\"hanging-indent\">TED. (2014, November 20). Joe Landolina: This gel can make you stop bleeding instantly. YouTube. https:\/\/www.youtube.com\/watch?v=e-5wqwp64MM&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2020, January 27). How bones make blood - Melody Smith. YouTube. https:\/\/www.youtube.com\/watch?v=1Qfmkd6C8u8&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3129\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3129\"><div tabindex=\"-1\"><p>Image shows a labelled diagram of the posterior (from the back) view of the kidneys.  The aorta and renal arteries are clearly visible bringing blood to each kidney.  The left kidney sits a bit higher than the right kidney.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3542\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3542\"><div tabindex=\"-1\"><p>The process by which a parent cell divides into two or more daughter cells. Cell division usually occurs as part of a larger cell cycle.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3566\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3566\"><div tabindex=\"-1\"><p>Long chains of hydrocarbons with a carboxyl group and a methyl group at opposite ends.  Can be either saturated, containing mostly single bonds between adjacent carbons, or unsaturated, containing many double bonds between adjacent carbons.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3568\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3568\"><div tabindex=\"-1\"><p>An antibody, also known as an immunoglobulin, is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3569\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3569\"><div tabindex=\"-1\"><p>A hormone is a signaling molecule produced by glands in multicellular organisms that target distant organs to regulate physiology and behavior.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3570\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3570\"><div tabindex=\"-1\"><p>A hormone is a signaling molecule produced by glands in multicellular organisms that target distant organs to regulate physiology and behavior.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3571\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3571\"><div tabindex=\"-1\"><p>The movement of water or other solvent through a plasma membrane from a region of low solute concentration to a region of high solute concentration.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3572\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3572\"><div tabindex=\"-1\"><p>The movement of water or other solvent through a plasma membrane from a region of low solute concentration to a region of high solute concentration.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5839\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5839\"><div tabindex=\"-1\"><p>Small muscles attached to hair follicles in mammals. Contraction of these muscles causes the hairs to stand on end, known colloquially as goose bumps.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_2937\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_2937\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-455\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Free_Awesome_Girl_With_Braces_Close_Up.jpg\" alt=\"\" width=\"400\" height=\"409\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.1 Brace yourself!\u00a0<\/em><\/figcaption><\/figure>\n<h1>Oh, the Agony!<\/h1>\n<p>Wearing braces can be very uncomfortable, but it is usually worth it. Braces and other orthodontic treatments can re-align the teeth and jaws to improve bite and appearance. Braces can change the position of the teeth and the shape of the jaws because the human body is malleable. Many phenotypic traits \u2014 even those that have a strong genetic basis \u2014 can be molded by the environment. Changing the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2477\">phenotype<\/a> in response to the environment is just one of several ways we respond to environmental stress.<\/p>\n<div>\n<h1>Types of Responses to Environmental Stress<\/h1>\n<\/div>\n<p>There are four different types of responses that humans may make to cope with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2653\">environmental stress<\/a>:<\/p>\n<ol>\n<li>Adaptation<\/li>\n<li>Developmental adjustment<\/li>\n<li>Acclimatization<\/li>\n<li>Cultural responses<\/li>\n<\/ol>\n<p>The first three types of responses are biological in nature, and the fourth type is cultural. Only adaptation involves genetic change and occurs at the level of the population or species. The other three responses do not require genetic change, and they occur at the individual level.<\/p>\n<div>\n<h1>Adaptation<\/h1>\n<\/div>\n<p>An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2486\">adaptation<\/a><\/strong>\u00a0is a genetically-based trait that has evolved because it helps living things survive and reproduce in a given environment. Adaptations generally evolve in a population over many generations in response to stresses that last for a long period of time. Adaptations come about through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2633\">natural selection<\/a>. Those individuals who inherit a trait that confers an advantage in coping with an environmental stress are likely to live longer and reproduce more. As a result, more of their genes pass on to the next generation. Over many generations, the genes and the trait they control become more frequent in the population.<\/p>\n<h2>A Classic Example: Hemoglobin S and Malaria<\/h2>\n<p>Probably the most frequently-cited example of a genetic adaptation to an environmental stress is sickle cell trait. As you read in the previous section, people with sickle cell trait have one abnormal allele (S) and one normal allele (A) for hemoglobin, the red blood cell protein that carries oxygen in the blood. Sickle cell trait is an adaptation to the environmental stress of malaria, because people with the trait have resistance to this parasitic disease. In areas where malaria is endemic (present year-round), the sickle cell trait and its <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_1942\">allele<\/a> have evolved to relatively high frequencies. \u00a0It is a classic example of natural selection favoring <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2474\">heterozygotes<\/a> for a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2035\">gene<\/a> with two <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_1942\">alleles<\/a>. This type of selection keeps both alleles at relatively high frequencies in a population.<\/p>\n<h2>To Taste or Not to Taste<\/h2>\n<p>Another example of an adaptation in humans is the ability to taste bitter compounds. Plants produce a variety of toxic compounds in order to protect themselves from being eaten, and these toxic compounds often have a bitter taste. The ability to taste bitter compounds is thought to have evolved as an adaptation, because it prevented people from eating poisonous plants. Humans have many different genes that code for bitter taste receptors, allowing us to taste a wide variety of bitter compounds.<\/p>\n<p>A harmless bitter compound\u00a0called\u00a0<strong>phenylthiocarbamide (PTC)<\/strong>\u00a0is not found naturally in plants, but it is similar to toxic bitter compounds that\u00a0<em>are<\/em> found in plants. Humans' ability to taste this harmless substance has been tested in many different populations. In virtually every population studied, there are some people who can taste PTC (called tasters), and some people who cannot taste PTC, (called nontasters). The ratio of tasters to non-tasters varies among populations, but on average, 75 per cent of people can taste PTC and 25 per cent cannot.<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 272px\" class=\"wp-caption alignright\"><img class=\" wp-image-456\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Tongue.jpg\" alt=\"Tongue\" width=\"272\" height=\"288\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.2 The tiny red dots on the surface of the tongue consist of clumps of taste buds that contain receptor proteins for certain chemicals. We can taste those chemicals that bind strongly with any of the receptors.<\/em><\/figcaption><\/figure>\n<p>Like many scientific discoveries, human variation in PTC-taster status was discovered by chance. Around 1930, a chemist named Arthur Fox was working with powdered PTC in his lab. Some of the powder accidentally blew into the air. Another lab worker noticed that the powdered PTC tasted bitter, but Fox couldn't detect any taste at all. Fox wondered\u00a0how to explain\u00a0this difference in PTC-tasting ability. Geneticists soon determined that PTC-taster status is controlled by a single <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2035\">gene<\/a> with two common alleles, usually represented by the letters\u00a0<em>T<\/em>\u00a0and\u00a0<em>t<\/em>. The\u00a0<em>T<\/em> allele encodes a chemical receptor protein (found in taste buds on the tongue, as illustrated in Figure 6.4.2) that can strongly bind to PTC. The other allele, <em>t<\/em>, encodes a version of the receptor protein that cannot bind as strongly to PTC. The particular combination of these two alleles that a person inherits determines whether the person finds PTC to taste very bitter (<em>TT<\/em>), somewhat bitter\u00a0<em>(Tt),<\/em>\u00a0or not bitter at all\u00a0<em>(tt).<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>If the ability to taste bitter compounds is advantageous, why does every human population studied contain a significant percentage of people who are nontasters?\u00a0Why has the nontasting allele been preserved in human populations at all? Some scientists hypothesize that the nontaster allele actually confers the ability to taste some other, yet-to-be identified, bitter compound in plants. People who inherit both alleles would presumably be able to taste a wider range of bitter compounds, so they would have the greatest ability to avoid plant toxins. In other words, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2474\">heterozygote<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2715\">genotype<\/a> for the taster gene would be the most fit and favored by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2633\">natural selection<\/a>.<\/p>\n<p>Most people no longer have to worry whether the plants they eat contain toxins. The produce you grow in your garden or buy at the supermarket consists of known varieties that are safe to eat. However, natural selection may still be at work in human populations for the PTC-taster gene, because PTC tasters may be more sensitive than nontasters to bitter compounds in tobacco and vegetables in the cabbage family (that is, cruciferous vegetables, such as the broccoli, cauliflower, and cabbage pictured in Figure 6.4.3).<\/p>\n<ul>\n<li>People who find PTC to taste very bitter are less likely to smoke tobacco, presumably because tobacco smoke has a stronger bitter taste to these individuals. In this case, selection would favor taster genotypes, because tasters would be more likely to avoid smoking and its serious health risks.<\/li>\n<li>Strong tasters find cruciferous vegetables to taste bitter. As a result, they may avoid eating these vegetables (and perhaps other foods, as well), presumably resulting in a diet that is less varied and nutritious. In this scenario, natural selection\u00a0might\u00a0work against taster genotypes.<\/li>\n<\/ul>\n<p><span style=\"text-align: initial;font-size: 1em\"><\/p>\n<div id=\"h5p-86\">\n<div class=\"h5p-content\" data-content-id=\"86\"><\/div>\n<\/div>\n<p><\/span><\/p>\n<p><em>Figure 6.4.3 Cruciferous vegetables.<\/em><\/p>\n<div>\n<h1>Developmental Adjustment<\/h1>\n<\/div>\n<p>It takes a relatively long time for genetic change in response to environmental stress to produce a population with adaptations. Fortunately, we can adjust to some environmental stresses more quickly by changing in nongenetic ways. One type of nongenetic response to stress is\u00a0<strong>developmental adjustment.<\/strong>\u00a0This refers to phenotypic change that occurs during development in infancy or childhood, and that may persist into adulthood. This type of change may be irreversible by adulthood.<\/p>\n<h2>Phenotypic Plasticity<\/h2>\n<p>Developmental adjustment is possible because humans have a high degree of\u00a0<strong>phenotypic plasticity,<\/strong>\u00a0which is\u00a0the ability to alter\u00a0the<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2477\"> phenotype<\/a> in response to changes in the environment. Phenotypic plasticity allows us to respond to changes that occur within our lifetime, and it is particularly important for species\u00a0(like our own)\u00a0that have a long generation time. With long generations, evolution of genetic adaptations may occur too slowly to keep up with changing environmental stresses.<\/p>\n<h2>Developmental Adjustment and Cultural Practices<\/h2>\n<p>Developmental adjustment may be the result of naturally occurring environmental stresses or cultural practices, including medical or dental treatments. Like our example at the beginning of this section, using braces to change the shape of the jaw and the position of the teeth is an example of a dental practice that brings about a developmental adjustment. Another example of developmental adjustment is the use of a back brace to treat scoliosis (see images in <em>Figure 6.4.4<\/em>). Scoliosis is an abnormal curvature from side to side in the spine. If the problem is not too severe, a brace, if worn correctly, should prevent the curvature from worsening as a child grows, although it cannot straighten a curve that is already present. Surgery may be required to do that.<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 651px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-457\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg.png\" alt=\"\" width=\"651\" height=\"342\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.4 Scoliosis can be prevented from worsening by shaping the phenotype with a back brace.<\/em><\/figcaption><\/figure>\n<h2>Developmental Adjustment and Nutritional Stress<\/h2>\n<p>An important example of developmental adjustment that results from a naturally occurring environmental stress is the cessation of physical growth that occurs in children who are under nutritional stress. Children who lack adequate food to fuel both growth and basic metabolic processes are likely to slow down in their growth rate \u2014 or even to stop growing entirely. Shunting all available calories and nutrients into essential life functions may keep the child alive at the expense of increasing body size.<\/p>\n<p>Table 6.4.1 shows the effects of inadequate diet on children's' growth in several countries worldwide. For each country, the table gives the prevalence of <strong>stunting<\/strong>\u00a0in children under\u00a0the age of five. Children are considered stunted if their height is at least two standard deviations below the median height for their age in an international reference population.<\/p>\n<p><strong>Table 6.4.1<\/strong><\/p>\n<p><em>Percentage of Stunting in Young Children in Selected Countries (2011-2015)<\/em><\/p>\n<table class=\"grid aligncenter\" style=\"border-collapse: collapse;width: 53.0094%;height: 142px\" border=\"0\">\n<tbody>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 52.9369%;text-align: center\" colspan=\"2\"><strong>Percentage of Stunting in Young Children in Selected Countries (2011-2015)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 16px\">\n<td style=\"height: 16px;width: 22.19%\"><strong>Country<\/strong><\/td>\n<td style=\"height: 16px;width: 30.7469%\"><strong>Per cent of Children Under Age 5 with Stunting<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">United States<\/td>\n<td style=\"height: 14px;width: 30.7469%\">2.1<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Turkey<\/td>\n<td style=\"height: 14px;width: 30.7469%\">9.5<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Mexico<\/td>\n<td style=\"height: 14px;width: 30.7469%\">13.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Thailand<\/td>\n<td style=\"height: 14px;width: 30.7469%\">16.3<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Iraq<\/td>\n<td style=\"height: 14px;width: 30.7469%\">22.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Philippines<\/td>\n<td style=\"height: 14px;width: 30.7469%\">33.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Pakistan<\/td>\n<td style=\"height: 14px;width: 30.7469%\">45.0<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Papua New Guinea<\/td>\n<td style=\"height: 14px;width: 30.7469%\">49.5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>After a growth slow-down occurs and if adequate food becomes available, a child may be able to make up the loss of growth. If food is plentiful, the child may grow more rapidly than normal until the original, genetically-determined growth trajectory is reached. If the inadequate diet persists, however, the failure of growth may become chronic, and the child may never reach his or her full potential adult size.<\/p>\n<p>Phenotypic plasticity of body size in response to dietary change has been observed in successive generations within populations. For example, children in Japan were taller, on average, in each successive generation\u00a0after\u00a0the end of World War II. Boys aged 14-15 years old in 1986 were an average of about 18 cm (7 in.) taller than boys of the same age in 1959, a generation earlier. This is a highly significant difference, and it occurred too quickly to be accounted for by genetic change. Instead, the increase in height is a developmental adjustment, thought to be largely attributable to changes in the Japanese diet since World War II. During this period, there was an increase in the amount of animal protein and fat, as well as in the total calories consumed.<\/p>\n<div>\n<h1>Acclimatization<\/h1>\n<\/div>\n<p>Other responses to environmental stress are reversible and not permanent, whether they occur in childhood or adulthood. The development of reversible changes to environmental stress is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2483\">acclimatization<\/a>.<\/strong>\u00a0Acclimatization generally develops over a relatively short period of time.\u00a0It may take just a few days or weeks to attain a maximum response to a stress. When the stress is no longer present, the acclimatized state declines, and the body returns to its normal baseline state. Generally, the shorter the time for acclimatization to occur, the more quickly the condition is reversed when the environmental stress is removed.<\/p>\n<h2>Acclimatization to UV Light<\/h2>\n<p>A common example of acclimatization is tanning of the skin (see Figure 6.4.5). This occurs in many people in response to exposure to ultraviolet radiation from the sun. Special pigment cells in the skin, called melanocytes, produce more of the brown pigment melanin when exposed to sunlight. The melanin collects near the surface of the skin where it absorbs UV radiation so it cannot penetrate and potentially damage deeper skin structures. Tanning is a reversible change in the phenotype that helps the body deal temporarily with the environmental stress of high levels of UV radiation. When the skin is no longer exposed to the sun\u2019s rays, the tan fades, generally over a period of a few weeks or months.<\/p>\n<div id=\"h5p-87\">\n<div class=\"h5p-content\" data-content-id=\"87\"><\/div>\n<\/div>\n<p><em>Figure 6.4.5 Tanning of the skin occurs in many people in response to exposure to ultraviolet radiation from the sun.<\/em><\/p>\n<div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Acclimatization to Heat<\/span><\/p>\n<\/div>\n<p>Another common example of acclimatization occurs in response to heat. Changes that occur with heat acclimatization include increased sweat output and earlier onset of sweat production, which helps the body stay cool because evaporation of sweat takes heat from the body\u2019s surface in a process called evaporative cooling. It generally takes a couple of weeks for maximum heat acclimatization to come about by gradually working out harder and longer at high air temperatures. The changes that occur with acclimatization just as quickly subside when the body is no longer exposed to excessive heat.<\/p>\n<h2>Acclimatization to High Altitude<\/h2>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 420px\" class=\"wp-caption alignleft\"><img class=\" wp-image-458\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nepalese-base-camp-by-Mark-Horrell-on-Flickr-CC-BY-NC-SA-.jpg\" alt=\"Base camp in Nepal\" width=\"420\" height=\"315\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.6 Mountaineers must spend 4-5 days acclimatizing to high altitude before attempting to climb to the summit of Mount Everest.<\/em><\/figcaption><\/figure>\n<p>Short term acclimatization to high altitude occurs as a response to low levels of oxygen in the blood.\u00a0 This reduced level of oxygen is detected by carotid bodies, which will trigger in increase in breathing and heart rate.\u00a0 Over a period of weeks the body will compensate by increasing red blood cell production, thereby improving the oxygen-carrying capacity of the blood.\u00a0 This is why mountaineers wishing to climb to the peak of Mount Everest must complete the full climb in portions; it is recommended that climbers spend 2-3 days acclimatizing for every 600 metres of elevation increase.\u00a0 In addition, the higher to altitude, the longer it make take to acclimatize; climbers are advised to spend 4-5 days acclimatizing at base camp (whether the base camp in Nepal or China) before completing the final leg of the climb to the peak.\u00a0 The concentration of red blood cells gradually decreases to normal levels once a climber returns to their normal elevation.<\/p>\n<div>\n<h1>Cultural Responses<\/h1>\n<\/div>\n<p>More than any other species, humans respond to environmental stresses with learned behaviors and technology. These cultural responses allow us to change our environments to control stresses, rather than changing our bodies genetically or physiologically to cope with the stresses. Even archaic humans responded to some environmental stresses in this way. For example, Neanderthals used shelters, fires, and animal hides as clothing to stay warm in the cold climate in Europe during the last ice age. Today, we use more sophisticated technologies to stay warm in cold climates while retaining our essentially tropical-animal anatomy and physiology. We also use technology (such as furnaces and air conditioners) to avoid temperature stress and stay comfortable in hot or cold climates.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Humans may respond to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2653\">environmental stress <\/a>in four different ways: adaptation, developmental adjustment, acclimatization, and cultural responses.<\/li>\n<li>An adaptation is a genetically based trait that has evolved because it helps living things survive and reproduce in a given environment. Adaptations evolve by natural selection in populations over a relatively long period to time. Examples of adaptations include sickle cell trait as an adaptation to the stress of endemic malaria and the ability to taste bitter compounds as an adaptation to the stress of bitter-tasting toxins in plants.<\/li>\n<li>A developmental adjustment is a non-genetic response to stress that occurs during infancy or childhood, and that may persist into adulthood. This type of change may be irreversible. Developmental adjustment is possible because humans have a high degree of phenotypic plasticity. It may be the result of environmental stresses (such as inadequate food), which may stunt growth, or cultural practices (such as orthodontic treatments), which re-align the teeth and jaws.<\/li>\n<li>Acclimatization is the development of reversible changes to environmental stress that develop over a relatively short period of time. The changes revert to the normal baseline state after the stress is removed. Examples of acclimatization include tanning of the skin and physiological changes (such as increased sweating) that occur with heat acclimatization.<\/li>\n<li>More than any other species, humans respond to environmental stress with learned behaviors and technology, which are cultural responses. These responses allow us to change our environment to control stress, rather than changing our bodies genetically or physiologically to cope with stress. Examples include using shelter, fire, and clothing to cope with a cold climate.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>List four different types of responses that humans may make to cope with environmental stress.<\/li>\n<li>Define adaptation.<\/li>\n<li>\n<div id=\"h5p-88\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-88\" class=\"h5p-iframe\" data-content-id=\"88\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Human Responses to Environmental Stress\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Explain how natural selection may have resulted in most human populations having people who can and people who cannot taste PTC.<\/li>\n<li>What is a developmental adjustment?<\/li>\n<li>Define phenotypic plasticity.<\/li>\n<li>Explain why phenotypic plasticity may be particularly important in a species with a long generation time.<\/li>\n<li>Why may stunting of growth occur in children who have an inadequate diet? Why is stunting preferable to the alternative?<\/li>\n<li>What is acclimatization?<\/li>\n<li>How does acclimatization to heat come about, and what are two physiological changes that occur in heat acclimatization?<\/li>\n<li>Give an example of a cultural response to heat stress.<\/li>\n<li>Which is more likely to be reversible \u2014 a change due to acclimatization, or a change due to developmental adjustment? Explain your answer.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=upp9-w6GPhU<\/p>\n<p style=\"text-align: center\">Could we survive prolonged space travel? - Lisa Nip, TED-Ed, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=hRnrIpUMyZQ&amp;t=182s<\/p>\n<p style=\"text-align: center\">How this disease changes the shape of your cells - Amber M. Yates, TED-Ed, 2019.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 6.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Free_Awesome_Girl_With_Braces_Close_Up.jpg\" rel=\"cc:attributionURL\">Free_Awesome_Girl_With_Braces_Close_Up<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/people\/40645538@N00\" rel=\"nofollow\">D. Sharon Pruitt<\/a> from Hill Air Force Base, Utah, USA on Wikimedia Commons is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en) license.<\/p>\n<p><strong>Figure 6.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:%D8%B2%D8%A8%D8%A7%D9%86_tongue.jpg\" rel=\"cc:attributionURL\">Tongue<\/a> by <a class=\"new\" title=\"User:Mahdiabbasinv (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Mahdiabbasinv&amp;action=edit&amp;redlink=1\">Mahdiabbasinv<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en) license.<\/p>\n<p><strong>Figure 6.4.3<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/unsplash.com\/photos\/PT-GXFtQj-s\">White cauliflower on brown wooden chopping board<\/a> by <a href=\"https:\/\/unsplash.com\/@louishansel\">Louis Hansel @shotsoflouis<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/LpHYbY6Qu_o\">Broccoli on wooden chopping board<\/a> by <a href=\"https:\/\/unsplash.com\/@louishansel\">Louis Hansel @shotsoflouis<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/knGwkn2j4ro\">Green cabbage close up<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@photoliphecjd\">Craig Dimmick<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/2Qzk3EJLNGE\">Cabbage hybrid\/ brussel sprouts<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@darkersolstice\">Solstice Hannan<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/_zV74zUnwmc\">Kale<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@lauramakoj\">Laura Johnston<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/v25z8P-CPB4\">Tiny bok choy at the Asian market<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@twoluckyspoons\">Jodie Morgan<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<\/ul>\n<p><strong>Figure 6.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg.png\" rel=\"cc:attributionURL\">Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg<\/a> by Weiss H.R. from <a href=\"https:\/\/scoliosisjournal.biomedcentral.com\/articles\/10.1186\/1748-7161-2-19\">Scoliosis Journal\/BioMed Central Ltd<\/a>. on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 6.4.5<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/21077319@N02\/3667901661\">Tan Lines<\/a> by <a class=\"owner-name truncate\" title=\"Go to k.steudel's photostream\" href=\"https:\/\/www.flickr.com\/photos\/snaks\/\" data-track=\"attributionNameClick\">k.steudel<\/a> on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/3760162521\/sizes\/l\/\">Twin tan lines (all sizes)<\/a> by <a class=\"owner-name truncate\" title=\"Go to Quinn Dombrowski's photostream\" href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/\" data-track=\"attributionNameClick\">Quinn Dombrowski<\/a>\u00a0on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/14518898810\">Wedding ring tan line<\/a> by <a class=\"owner-name truncate\" title=\"Go to Quinn Dombrowski's photostream\" href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/\" data-track=\"attributionNameClick\">Quinn Dombrowski<\/a>\u00a0on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/29333334@N06\/3792695572\">Tan<\/a> by <a class=\"owner-name truncate\" title=\"Go to Evil Erin's photostream\" href=\"https:\/\/www.flickr.com\/photos\/evilerin\/\" data-track=\"attributionNameClick\">Evil Erin<\/a> on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<\/ul>\n<p><strong style=\"text-align: initial;font-size: 1em\">Figure 6.4.6<\/strong><\/p>\n<p><a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/www.flickr.com\/photos\/markhorrell\/18787430274\/in\/photostream\/\" rel=\"cc:attributionURL\">Nepalese base camp<\/a> by <a class=\"owner-name truncate\" title=\"Go to Mark Horrell's photostream\" href=\"https:\/\/www.flickr.com\/photos\/markhorrell\/\" data-track=\"attributionNameClick\">Mark Horrell<\/a><span style=\"text-align: initial;font-size: 1em\">\u00a0on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a\u00a0<\/span><a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">TED-Ed. (2016, October 4). Could we survive prolonged space travel? - Lisa Nip. YouTube. https:\/\/www.youtube.com\/watch?v=upp9-w6GPhU&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2019, May 6). How this disease changes the shape of your cells - Amber M. Yates. YouTube. https:\/\/www.youtube.com\/watch?v=hRnrIpUMyZQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Weiss, H. (2007). Is there a body of evidence for the treatment of patients with Adolescent Idiopathic Scoliosis (AIS)? [Figure 2 - digital photograph],\u00a0 <i>Scoliosis, <\/i>2(19).\u00a0https:\/\/doi.org\/10.1186\/1748-7161-2-19<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5915\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5915\"><div tabindex=\"-1\"><p>The central nervous system organ inside the skull that is the control center of the nervous system.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3124\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3124\"><div tabindex=\"-1\"><p>As per caption<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3125\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3125\"><div tabindex=\"-1\"><p>Image shows a diagram of the bladder. There is smooth muscle in the bladder walls which are under involuntary control.  There is a sphincter between the bladder and the urethra which can inhibit urination.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3126\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3126\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<div id=\"h5p-413\">\n<div class=\"h5p-content\" data-content-id=\"413\"><\/div>\n<\/div>\n<p><em>Figure 16.3.1 The surprising uses of pee.<\/em><\/p>\n<div>\n<h1>Surprising Uses<\/h1>\n<\/div>\n<p>What do gun powder, leather, fabric dyes and laundry service have in common?\u00a0 This may be surprising, but they all historically involved urine.\u00a0 One of the main components in gun powder, potassium nitrate, was difficult to come by pre-1900s, so ingenious gun-owners would evaporate urine to concentrate the nitrates it contains.\u00a0 The ammonium in urine was excellent in breaking down tissues, making it a prime candidate for softening leathers and removing stains in laundry.\u00a0 Ammonia in urine also helps dyes penetrate fabrics, so it was used to make colours stay brighter for longer.<\/p>\n<div>\n<h1>What is the Urinary System?<\/h1>\n<\/div>\n<p>The actual human\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2914\">urinary system<\/a><\/strong>, also known as the renal system, is shown in Figure 16.3.2. The system consists of the kidneys, ureters, bladder, and urethra. The main function of the urinary system is to eliminate the waste products of metabolism from the body by forming and excreting <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4717\">urine<\/a>.<\/strong> Typically, between one and two litres of urine are produced every day in a healthy individual.<\/p>\n<figure id=\"attachment_4722\" aria-describedby=\"caption-attachment-4722\" style=\"width: 560px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4722\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Urinary_System_Male-1.png\" alt=\"16.3.2 Urinary System\" width=\"560\" height=\"560\"><figcaption id=\"caption-attachment-4722\" class=\"wp-caption-text\"><em>16.3.2 The components of the urinary system include the two kidneys, two ureters, bladder, and urethra. The urinary system is the same in males and females, except the urethra is longer in males.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Organs of the Urinary System<\/h1>\n<\/div>\n<p>The urinary system is all about urine. It includes organs that form urine, and also those that transport, store, or excrete urine.<\/p>\n<h2>Kidneys<\/h2>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4717\">Urine<\/a> is formed by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2988\">kidneys<\/a>, which filter many substances out of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2702\">blood<\/a>, allow the blood to reabsorb needed materials, and use the remaining materials to form urine. The human body normally has two paired kidneys, although it is possible to get by quite well with just one. As you can see in Figure 16.3.3, each kidney is well supplied with blood vessels by a major artery and vein. Blood to be filtered enters the kidney through the renal artery, and the filtered blood leaves the kidney through the renal vein. The kidney itself is wrapped in a fibrous capsule, and consists of a thin outer layer called the cortex, and a thicker inner layer called the medulla.<\/p>\n<figure id=\"attachment_4723\" aria-describedby=\"caption-attachment-4723\" style=\"width: 1024px\" class=\"wp-caption alignnone\"><img class=\"size-full wp-image-4723\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2610_The_Kidney-1.jpg\" alt=\"16.3.3 The Kidney\" width=\"1024\" height=\"585\"><figcaption id=\"caption-attachment-4723\" class=\"wp-caption-text\"><em>Figure 16.3.3 The structure of the kidney is specialized to filter blood and form and collect urine.<\/em><\/figcaption><\/figure>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2702\">Blood<\/a> is filtered and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4717\">urine<\/a> is formed by tiny filtering units called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4718\">nephron<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. Each kidney contains at least a million nephrons, and each nephron spans the cortex and medulla layers of the kidney. After urine forms in the nephrons, it flows through a system of converging collecting ducts. The collecting ducts join together to form minor calyces (or chambers) that join together to form major calyces (see Figure 16.3.3 above). Ultimately, the major calyces join the <\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4724\">renal pelvis<\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">, which is the funnel-like end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4725\">ureter<\/a> where it enters the kidney.<\/span><\/p>\n<h2>Ureters, Bladder, Urethra<\/h2>\n<p>After urine forms in the kidneys, it is transported through the ureters (one per kidney) via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2890\">peristalsis<\/a> to the sac-like urinary bladder, which stores the urine until <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4726\">urination<\/a>. <\/strong>During urination, the urine is released from the bladder and transported by the urethra to be excreted outside the body through the external urethral opening.<\/p>\n<div>\n<h1>Functions of the Urinary System<\/h1>\n<\/div>\n<p>Waste products removed from the body with the formation and elimination of urine include many water-soluble metabolic products. The main waste products are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4708\">urea<\/a> \u2014 a by-product of\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3721\">protein<\/a>\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3629\">catabolism<\/a> \u2014 and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4709\">uric\u00a0acid<\/a>, a by-product of\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4727\">nucleic acid<\/a>\u00a0catabolism. Excess\u00a0water\u00a0and mineral ions are also eliminated in urine.<\/p>\n<p>Besides the elimination of waste products such as these, the urinary system has several other vital functions. These include:<\/p>\n<ul>\n<li><strong>Maintaining<\/strong><strong>\u00a0homeostasis\u00a0of mineral ions in extracellular fluid<\/strong>: These ions are either excreted in urine or returned to the blood as needed to maintain the proper balance.<\/li>\n<li><strong>Maintaining homeostasis of blood pH<\/strong>:\u00a0When\u00a0pH\u00a0is too low (blood is too acidic), for example, the kidneys excrete less bicarbonate (which is basic) in urine. When pH is too high (blood is too basic), the opposite occurs, and more bicarbonate is excreted in urine.<\/li>\n<li><strong>Maintaining homeostasis of extracellular fluids, including the blood volume, which helps maintain<\/strong><strong>\u00a0blood pressure:<\/strong>\u00a0The kidneys control fluid volume and\u00a0blood pressure\u00a0by excreting more or less salt and\u00a0water\u00a0in urine.<\/li>\n<\/ul>\n<div>\n<h1>Control of the Urinary System<\/h1>\n<\/div>\n<p>The formation of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4717\">urine<\/a> must be closely regulated to maintain body-wide\u00a0homeostasis. Several\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3893\">endocrine<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3569\">hormones<\/a>\u00a0help control this function of the urinary system, including antidiuretic\u00a0hormone, parathyroid hormone, and aldosterone.<\/p>\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3441\"><strong>Antidiuretic<\/strong><strong> hormone<\/strong><\/a><strong> (ADH)<\/strong>, also called vasopressin, is secreted by the\u00a0posterior\u00a0pituitary gland. One of its main roles is conserving body\u00a0water. It is released when the body is dehydrated, and it causes the kidneys to excrete less water in urine.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3467\"><strong>Parathyroid<\/strong><strong>\u00a0hormone<\/strong><\/a>\u00a0is secreted by the parathyroid glands. It works to regulate the balance of mineral ions in the body\u00a0via\u00a0its effects on several organs, including the kidneys. Parathyroid hormone stimulates the kidneys to excrete less calcium and more phosphorus in urine.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3789\">Aldosterone<\/a><\/strong> is secreted by the cortex of the adrenal glands, which rest atop the kidneys, as shown in Figure 16.3.4. Through its effect on the kidneys, it plays a central role in regulating blood pressure. It causes the kidneys to excrete less sodium and water in urine.<\/li>\n<\/ul>\n<figure id=\"attachment_4729\" aria-describedby=\"caption-attachment-4729\" style=\"width: 588px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4729 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Adrenal-glands-on-Kidney-by-NCI-Public-Domain-e1592620428819-1.jpg\" alt=\"16.3.4 Adrenal Glands\" width=\"588\" height=\"540\"><figcaption id=\"caption-attachment-4729\" class=\"wp-caption-text\"><em>Figure 16.3.4 The adrenal glands are located on top of the kidneys. They secrete aldosterone into the bloodstream, which carries it to the kidneys.<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_4730\" aria-describedby=\"caption-attachment-4730\" style=\"width: 428px\" class=\"wp-caption alignleft\"><img class=\" wp-image-4730\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Urinary_Sphincter-1.png\" alt=\"16.3.5 Urinary sphincter\" width=\"428\" height=\"428\"><figcaption id=\"caption-attachment-4730\" class=\"wp-caption-text\"><em>Figure 16.3.5 The urinary sphincter relaxes to allow urination.<\/em><\/figcaption><\/figure>\n<p>Once urine forms, it is excreted from the body in the process of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4726\">urination<\/a>, also sometimes referred to as micturition. This process is controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3807\">autonomic<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3014\">somatic<\/a> nervous systems. As the bladder fills with urine, it causes the autonomic nervous system to signal smooth muscle in the bladder wall to contract (as shown in Figure 16.3.5), and the sphincter between the bladder and urethra to relax and open. This forces urine out of the bladder and through the urethra. Another sphincter at the distal end of the urethra is under <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3004\">voluntary<\/a> control. When it relaxes under the influence of the somatic nervous system, it allows urine to leave the body through the external urethral opening.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2914\">urinary system<\/a> consists of the kidneys, ureters, bladder, and urethra. The main function of the urinary system is to eliminate the waste products of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3681\">metabolism<\/a> from the body by forming and excreting <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4717\">urine<\/a>.<\/li>\n<li>Urine is formed by the kidneys, which filter many substances out of blood, allow the blood to reabsorb needed materials, and use the remaining materials to form urine. Blood to be filtered enters the kidney through the renal artery, and filtered blood leaves the kidney through the renal vein.<\/li>\n<li>Within each <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2988\">kidney<\/a>, blood is filtered and urine is formed by tiny filtering units called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4718\">nephrons<\/a>, of which there are at least a million in each kidney.<\/li>\n<li>After urine forms in the kidneys, it is transported through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4725\">ureters<\/a> via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2890\">peristalsis<\/a> to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4731\">urinary bladder<\/a>. The bladder stores the urine until <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4726\">urination<\/a>, when urine is transported by the urethra to be excreted outside the body.<\/li>\n<li>Besides the elimination of waste products (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4708\">urea<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4709\">uric\u00a0acid<\/a>, excess water, and mineral ions), the urinary system has other vital functions. These include maintaining\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3669\">homeostasis<\/a>\u00a0of mineral ions in extracellular fluid, regulating acid-base\u00a0balance in the blood, regulating the volume of extracellular fluids, and controlling <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4480\">blood pressure<\/a>.<\/li>\n<li>The formation of urine must be closely regulated to maintain body-wide homeostasis. Several\u00a0endocrine hormones\u00a0help control this function of the urinary system, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3801\">antidiuretic hormone<\/a> from the\u00a0posterior\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_2938\">pituitary gland<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3467\">parathyroid hormone<\/a> from the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3402\">parathyroid glands<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3789\">aldosterone<\/a> from the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3777\">adrenal glands<\/a>.<\/li>\n<li>The process of urination is controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3807\">autonomic<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_3014\">somatic<\/a> nervous systems. The autonomic system causes the bladder to empty, but conscious relaxation of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4627\">sphincter<\/a> at the distal end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4877_4732\">urethra<\/a> allows urine to leave the body.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-414\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-414\" class=\"h5p-iframe\" data-content-id=\"414\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"16.3 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>State the main function of the urinary system.<\/li>\n<li>What are nephrons?<\/li>\n<li>Other than the elimination of waste products, identify functions of the urinary system.<\/li>\n<li>How is the formation of urine regulated?<\/li>\n<li>Explain why it is important to have voluntary control over the sphincter at the end of the urethra.<\/li>\n<li>In terms of how they affect the kidneys, compare aldosterone to antidiuretic hormone.<\/li>\n<li>If your body needed to retain more calcium, which of the hormones described in this concept is most likely to increase? Explain your reasoning.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/dxecGD0m0Xc<\/p>\n<p style=\"text-align: center\">The Urinary System - An Introduction | Physiology | Biology | FuseSchool, 2017.<\/p>\n<p>https:\/\/youtu.be\/pyMcTUQYMQw<\/p>\n<p style=\"text-align: center\">Maple Syrup Urine Disease, Alexandria Doody, 2016.<\/p>\n<p>https:\/\/youtu.be\/3z-xjfdJWAI<\/p>\n<p style=\"text-align: center\">How Accurate Are Drug Tests? Seeker, 2016.<\/p>\n<p>https:\/\/youtu.be\/xt1Tj5eeS0k<\/p>\n<p style=\"text-align: center\">Three Ways Pee Could Change the World, Gross Science, 2015.<\/p>\n<\/div>\n<\/div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Attributions<\/span><\/p>\n<\/div>\n<p><strong>Figure 16.3.1<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Pyrodex_powder_ffg.jpg\">File:Pyrodex powder ffg.jpg<\/a> by <a title=\"User:Hustvedt\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Hustvedt\">Hustvedt<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/pFLNV4gkXsc\">Brown leather satchel bag<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@alvaroserrano\">\u00c1lvaro Serrano<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash Licence<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/nHhGuO-2YPw\">Laundry basket<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@andyfitz\">Andy Fitzsimon<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash Licence<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/pixabay.com\/photos\/wool-skeins-natural-dyed-colorful-593794\/\">Tags: Wool Skeins Natural Dyed Colorful Himalayan Weavers<\/a> by\u00a0 on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/li>\n<\/ul>\n<p><strong>Figure 16.3.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Urinary_System_(Male).png\" rel=\"cc:attributionURL\">Urinary_System_(Male)<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.3.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2610_The_Kidney.jpg\" rel=\"cc:attributionURL\">2610_The_Kidney<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.3.4<\/strong><\/p>\n<p><a href=\"https:\/\/visuals.nci.nih.gov\/details.cfm?imageid=4355\" rel=\"cc:attributionURL\">Adrenal glands on Kidney<\/a>\u00a0 by <a href=\"https:\/\/visuals.nci.nih.gov\/details.cfm?imageid=4355\">Alan Hoofring (Illustrator)\/ NCI Visuals Online<\/a> is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.3.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Urinary_Sphincter.png\" rel=\"cc:attributionURL\">Urinary_Sphincter<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Alexandria Doody. (2016, March 29). Maple syrup urine disease. YouTube. https:\/\/www.youtube.com\/watch?v=pyMcTUQYMQw&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><span class=\"os-number\">25.8<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"3662\" class=\"os-title\" data-type=\"title\">Left kidney [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 25.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney<\/span><\/p>\n<p class=\"hanging-indent\">FuseSchool. (2017, June 19). The urinary system - An introduction | Physiology | Biology | FuseSchool. YouTube. https:\/\/www.youtube.com\/watch?v=dxecGD0m0Xc&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Gross Science. (2015, September 15). Three ways pee could change the world. YouTube. https:\/\/www.youtube.com\/watch?v=xt1Tj5eeS0k&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Seeker. (2016, January 16). How accurate are drug tests? YouTube. https:\/\/www.youtube.com\/watch?v=3z-xjfdJWAI&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5761\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5761\"><div tabindex=\"-1\"><p>The ability of an organism to maintain constant internal conditions despite external changes.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5773\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5773\"><div tabindex=\"-1\"><p>The chemical processes that occur in a living organism to sustain life.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_3576\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_3576\"><div tabindex=\"-1\"><p>A specific reactant in a chemical reaction which works with a specific enzyme.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4877_5835\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4877_5835\"><div tabindex=\"-1\"><p>A hollow, tube-like structure through which blood flows in the cardiovascular system; vein, artery, or capillary.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"author":32,"menu_order":4,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":"cc-by-nc"},"chapter-type":[48],"contributor":[],"license":[55],"class_list":["post-4877","chapter","type-chapter","status-publish","hentry","chapter-type-numberless","license-cc-by-nc"],"part":4853,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/users\/32"}],"version-history":[{"count":3,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4877\/revisions"}],"predecessor-version":[{"id":6453,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4877\/revisions\/6453"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/parts\/4853"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4877\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/media?parent=4877"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapter-type?post=4877"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/contributor?post=4877"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/license?post=4877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}