{"id":4862,"date":"2019-06-24T15:06:55","date_gmt":"2019-06-24T15:06:55","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/12-2-introduction-to-the-integumentary-system-3\/"},"modified":"2023-11-30T18:54:32","modified_gmt":"2023-11-30T18:54:32","slug":"12-2-introduction-to-the-integumentary-system-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/12-2-introduction-to-the-integumentary-system-3\/","title":{"raw":"10.2\u00a0Introduction to the Integumentary System","rendered":"10.2\u00a0Introduction to the Integumentary System"},"content":{"raw":"&nbsp;\r\n\r\n[caption id=\"attachment_3519\" align=\"aligncenter\" width=\"320\"]<img class=\"wp-image-3519\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Maud_Stevens_Wagner-2.jpeg-2.jpeg\" alt=\"10.2.1\" width=\"320\" height=\"450\" \/> <em>Figure 10.2.1 The body as a canvas.<\/em>[\/caption]\r\n\r\n<div>\r\n<h1>Art for All Eras<\/h1>\r\n<\/div>\r\nPictured in Figure 10.2.1, is Maud Stevens Wagner, a tattoo artist from 1907. Tattoos are not just a late 20th and early 21st century trend. They have been popular in many eras and cultures. Tattoos literally illustrate the biggest organ of the human body: the skin. The skin is very thin, but it covers a large area \u2014 about 2 m<sup>2<\/sup>\u00a0in adults. The skin is the major organ in the [pb_glossary id=\"2905\"]integumentary system[\/pb_glossary].\r\n<div>\r\n<h1>What Is the Integumentary System?<\/h1>\r\n<\/div>\r\nIn addition to the skin, the\u00a0<strong>[pb_glossary id=\"2905\"]integumentary system[\/pb_glossary]<\/strong>\u00a0includes the\u00a0hair\u00a0and\u00a0nails, which are organs that grow out of the skin. Because the organs of the integumentary system are mostly external to the body, you may think of them as little more than accessories, like clothing or jewelry, but they serve vital physiological functions. They provide a protective covering for the body, sense\u00a0the environment, and help the body maintain\u00a0[pb_glossary id=\"5761\"]homeostasis[\/pb_glossary].\r\n<div>\r\n<h1>The Skin<\/h1>\r\n<\/div>\r\nThe\u00a0<strong>[pb_glossary id=\"3521\"]skin[\/pb_glossary]<\/strong> is remarkable not only because it is the body\u2019s largest organ: the average square inch of skin has 20 blood vessels, 650 sweat glands, and more than 1,000 nerve endings. Incredibly, it also has 60,000 pigment-producing cells. All of these structures are packed into a stack of cells that is just 2 mm thick. Although the skin is thin, it consists of two distinct layers: the epidermis and dermis, as shown in the diagram (Figure 10.2.2).\r\n\r\n[caption id=\"attachment_3522\" align=\"alignnone\" width=\"587\"]<img class=\"wp-image-3522\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anatomy_The_Skin_-_NCI_Visuals_Online-2.jpg\" alt=\"Skin Diagram\" width=\"587\" height=\"585\" \/> <em>Figure 10.2.2 The epidermis is the thinner outer layer of skin, and the dermis is the thicker inner layer of skin. The latter contains structures such as blood vessels and sweat glands.<\/em>[\/caption]\r\n<h2>Outer Layer of Skin<\/h2>\r\nThe outer layer of skin is the\u00a0<strong>[pb_glossary id=\"5991\"]epidermis[\/pb_glossary]<\/strong>. This layer is thinner than the inner layer (the dermis). The epidermis consists mainly of epithelial\u00a0cells, called\u00a0<strong>[pb_glossary id=\"3524\"]keratinocytes[\/pb_glossary],<\/strong>\u00a0which produce the tough, fibrous\u00a0protein\u00a0<strong>[pb_glossary id=\"3525\"]keratin[\/pb_glossary].<\/strong>\u00a0The innermost\u00a0cells\u00a0of the epidermis are [pb_glossary id=\"3163\"]stem cells[\/pb_glossary]\u00a0that divide continuously to form new cells. The newly formed cells move up through the epidermis toward the skin surface, while producing more and more keratin. The cells become filled with keratin and die by the time they reach the surface, where they form a protective, waterproof layer. As the dead cells are shed from the surface of the skin, they are replaced by other cells that move up from below. The epidermis also contains [pb_glossary id=\"3526\"]<strong>melanocytes<\/strong>[\/pb_glossary], the cells that produce the brown pigment melanin, which gives skin most of its colour. Although the epidermis contains some sensory receptor cells \u2014 called [pb_glossary id=\"3527\"]Merkel cells[\/pb_glossary] \u2014 it contains no nerves, blood vessels, or other structures.\r\n<h2>Inner Layer of Skin<\/h2>\r\nThe\u00a0<strong>[pb_glossary id=\"5967\"]dermis[\/pb_glossary]<\/strong> is the inner, thicker layer of skin. It consists mainly of tough [pb_glossary id=\"2815\"]connective tissue[\/pb_glossary], and is attached to the epidermis by collagen fibres. The dermis contains many structures (as shown in Figure 10.2.2), including blood vessels, sweat glands, and hair follicles, which are structures where hairs originate. In addition, the dermis contains many sensory receptors, nerves, and oil glands.\r\n<h2>Functions of the Skin<\/h2>\r\nThe skin has multiple roles in the body. Many of these roles are related to\u00a0[pb_glossary id=\"5761\"]homeostasis[\/pb_glossary]. The skin\u2019s main functions\u00a0are\u00a0preventing\u00a0water\u00a0loss from the body and serving as a barrier to the entry of microorganisms. Another function of the skin is synthesizing vitamin D, which occurs when the skin is exposed to ultraviolet (UV) light. Melanin in the epidermis blocks some of the UV light and protects the dermis from its damaging effects.\r\n\r\nAnother important function of the skin is helping to regulate body temperature. When the body is too warm, for example, the skin lowers body temperature by producing sweat, which cools the body when it evaporates. The skin also increases the amount of blood flowing near the body surface through vasodilation (widening of blood vessels), bringing heat from the body core to radiate out into the environment. The sweaty hair and flushed skin of the young man pictured in Figure 10.2.3 reflect these skin responses to overheating.\r\n\r\n[caption id=\"attachment_3529\" align=\"aligncenter\" width=\"400\"]<img class=\"wp-image-3529\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/shashank-shekhar-Db1J_qp_ctc-unsplash-scaled-3.jpg\" alt=\"Man Sweating\" width=\"400\" height=\"267\" \/> <em>Figure 10.2.3 Both sweating and flushing of the skin are signs that the skin is working to cool the body.<\/em>[\/caption]\r\n\r\n<div>\r\n\r\n<span style=\"font-size: 1.602em; font-weight: bold;\">Hair<\/span>\r\n\r\n<\/div>\r\n\r\n[caption id=\"attachment_3532\" align=\"alignright\" width=\"200\"]<img class=\"wp-image-3532\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Eyelashes-by-aryan-dhiman-93NBu0zG_H4-unsplash-scaled-3.jpg\" alt=\"Eyelashes\" width=\"200\" height=\"267\" \/> <em>Figure 10.2.4 Eyelashes protect the eyes.<\/em>[\/caption]\r\n\r\n<strong>[pb_glossary id=\"3531\"]Hair[\/pb_glossary]<\/strong> is a fibre found only in mammals. It consists mainly of keratin-producing [pb_glossary id=\"3524\"]keratinocytes[\/pb_glossary]. Each hair grows out of a [pb_glossary id=\"6015\"]follicle[\/pb_glossary] in the [pb_glossary id=\"5967\"]dermis[\/pb_glossary]. By the time the hair reaches the surface, it consists mainly of dead cells filled with [pb_glossary id=\"3525\"]keratin[\/pb_glossary]. Hair serves several homeostatic functions. Head hair is important in preventing heat loss from the head and protecting its skin from UV radiation. Hairs in the nose trap dust particles and microorganisms in the air, and prevent them from reaching the lungs. Hair all over the body provides sensory input when objects brush against it, or when it sways in moving air. Eyelashes and eyebrows (see Figure 10.2.4) protect the eyes from water, dirt, and other irritants.\r\n<div>\r\n<h1>Nails<\/h1>\r\n<\/div>\r\nFingernails and toenails consist of dead [pb_glossary id=\"3524\"]keratinocytes[\/pb_glossary] filled with [pb_glossary id=\"3525\"]keratin[\/pb_glossary]. The keratin makes them hard but flexible, which is important for the functions they serve. [pb_glossary id=\"5495\"]Nails[\/pb_glossary]\u00a0prevent injury by forming protective plates over the ends of the fingers and toes. They also enhance sensation by acting as a counterforce to the sensitive fingertips when objects are handled. In addition, the fingernails can be used as tools.\r\n<div>\r\n<h1>Interactions with Other Organ Systems<\/h1>\r\n<\/div>\r\nThe skin and other parts of the [pb_glossary id=\"2905\"]integumentary system[\/pb_glossary] work with other organ systems to maintain\u00a0[pb_glossary id=\"5761\"]homeostasis[\/pb_glossary].\r\n<ul>\r\n \t<li>The skin works with the immune system to defend the body from pathogens by serving as a physical barrier to microorganisms.<\/li>\r\n \t<li>Vitamin D is needed by the\u00a0digestive system\u00a0to absorb calcium from food. By synthesizing vitamin D, the skin works with the digestive system to ensure that calcium can be absorbed.<\/li>\r\n \t<li>To control body\u00a0temperature, the skin works with the\u00a0cardiovascular system\u00a0to either lose body\u00a0heat, or to conserve it through vasodilation or vasoconstriction.<\/li>\r\n \t<li>To detect certain sensations from the outside world, the\u00a0nervous system\u00a0depends on nerve receptors in the skin.<\/li>\r\n<\/ul>\r\n<div>\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.2 Summary<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul>\r\n \t<li>The [pb_glossary id=\"2905\"]integumentary system[\/pb_glossary] consists of the [pb_glossary id=\"3521\"]skin[\/pb_glossary], [pb_glossary id=\"3531\"]hair[\/pb_glossary], and [pb_glossary id=\"5495\"]nails[\/pb_glossary]. Functions of the integumentary system include providing a protective covering for the body, sensing\u00a0the environment, and helping the body maintain homeostasis.<\/li>\r\n \t<li>The skin consists of two distinct layers: a thinner outer layer called the [pb_glossary id=\"5991\"]epidermis[\/pb_glossary], and a thicker\u00a0inner layer called the [pb_glossary id=\"5967\"]dermis[\/pb_glossary].<\/li>\r\n \t<li>The epidermis consists mainly of epithelial cells called [pb_glossary id=\"3524\"]keratinocytes[\/pb_glossary], which produce [pb_glossary id=\"3525\"]keratin[\/pb_glossary]. New keratinocytes form at the bottom of the epidermis. They become filled with keratin and die as they move upward toward the surface of the skin, where they form a protective, waterproof layer.<\/li>\r\n \t<li>The dermis consists mainly of tough [pb_glossary id=\"2815\"]connective tissues[\/pb_glossary]\u00a0and many structures, including blood vessels, sensory receptors, nerves, hair follicles, and oil and sweat glands.<\/li>\r\n \t<li>The [pb_glossary id=\"3521\"]skin[\/pb_glossary]\u2019s main functions\u00a0are\u00a0preventing\u00a0water\u00a0loss from the body, serving as a barrier to the entry of microorganisms, synthesizing vitamin D, blocking UV light, and helping to regulate body temperature.<\/li>\r\n \t<li>[pb_glossary id=\"3531\"]Hair[\/pb_glossary] consists mainly of dead keratinocytes and grows out of [pb_glossary id=\"6015\"]follicles[\/pb_glossary]\u00a0in the dermis. Hair helps prevent heat loss from the head, and protects its skin from UV light. Hair in the nose filters incoming air, and the eyelashes and eyebrows keep harmful substances out of the\u00a0eyes. Hair all over the body provides tactile sensory input.<\/li>\r\n \t<li>Like hair, [pb_glossary id=\"5495\"]nails[\/pb_glossary]\u00a0also consist mainly of dead keratinocytes. They help protect the ends of the fingers and toes, enhance the sense of touch in the fingertips, and may be used as tools.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.2 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ol>\r\n \t<li>Name the organs of the integumentary system.<\/li>\r\n \t<li>Compare and contrast the epidermis and dermis.<\/li>\r\n \t<li>Identify functions of the skin.<\/li>\r\n \t<li>[h5p id=\"581\"]<\/li>\r\n \t<li>What is the\u00a0composition of hair?<\/li>\r\n \t<li>Describe three physiological roles played by hair.<\/li>\r\n \t<li>What do nails consist of?<\/li>\r\n \t<li>List two functions of nails.<\/li>\r\n \t<li>In terms of\u00a0composition, what do the outermost surface of the skin, the nails, and hair have in common?<\/li>\r\n \t<li>Identify two types of cells found in the epidermis of the skin. Describe their functions.<\/li>\r\n \t<li>Which structure and layer of skin does hair grow out of?<\/li>\r\n \t<li>Identify three main functions of the integumentary system. Give an example of each.<\/li>\r\n \t<li>What are two ways in which the integumentary system protects the body against UV radiation?<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.2 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=OxPlCkTKhzY\r\n<p style=\"text-align: center;\">The science of skin - Emma Bryce, TED-Ed, 2018.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=ZSJITdsTze0&amp;feature=emb_logo\r\n<p style=\"text-align: center;\">Why do we have to wear sunscreen? - Kevin P. Boyd, TED-Ed, 2013.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?time_continue=1&amp;v=Lfhot7tQcWs&amp;feature=emb_logo\r\n<p style=\"text-align: center;\">Scarification | National Geographic, 2008.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n&nbsp;\r\n\r\n<\/div>\r\n<div id=\"content\" class=\"site-content\"><section class=\"standard post-793 chapter type-chapter status-publish hentry focusable\" data-type=\"chapter\">\r\n<h2>Attributions<\/h2>\r\n<strong>Figure 10.2.1<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Maud_Stevens_Wagner.jpeg\" rel=\"cc:attributionURL\">Maud_Stevens_Wagner <\/a>-The Plaza Gallery, Los Angeles, 1907\u00a0from the <a href=\"https:\/\/www.loc.gov\/pictures\/item\/2006687059\/\">Library of Congress<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).\r\n\r\n<strong>Figure 10.2.2<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anatomy_The_Skin_-_NCI_Visuals_Online.jpg\" rel=\"cc:attributionURL\">Anatomy_The_Skin_-_NCI_Visuals_Online<\/a> by Don Bliss (artist) from <a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a>, on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).\r\n\r\n<strong>Figure 10.2.3<\/strong>\r\n\r\n<a href=\"https:\/\/unsplash.com\/photos\/Db1J_qp_ctc\" rel=\"cc:attributionURL\">shashank-shekhar-Db1J_qp_ctc<\/a> [photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@5hashank\">Shashank Shekhar<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the \u00a0<a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).\r\n\r\n<strong>Figure 10.2.4<\/strong>\r\n\r\n<a href=\"https:\/\/unsplash.com\/photos\/93NBu0zG_H4\" rel=\"cc:attributionURL\">Eyelashes by aryan-dhiman-93NBu0zG_H4<\/a> [photo] by <a href=\"https:\/\/unsplash.com\/@mylifeasaryan_\">Aryan Dhiman<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the \u00a0<a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).\r\n\r\n&nbsp;\r\n\r\n<span style=\"font-size: 1.424em; font-weight: bold; color: #333333;\">Reference<\/span>\r\n\r\n<\/section><\/div>\r\n<p class=\"hanging-indent\">National Geographic. (2008). Scarification | National Geographic. YouTube. https:\/\/www.youtube.com\/watch?v=Lfhot7tQcWs&amp;t=1s<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2018, March 12). The science of skin - Emma Bryce. YouTube. https:\/\/www.youtube.com\/watch?v=OxPlCkTKhzY&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2013, August 6). Why do we have to wear sunscreen? - Kevin P. Boyd. YouTube. https:\/\/www.youtube.com\/watch?v=ZSJITdsTze0&amp;feature=youtu.be<\/p>\r\n&nbsp;","rendered":"<p>&nbsp;<\/p>\n<figure id=\"attachment_3519\" aria-describedby=\"caption-attachment-3519\" style=\"width: 320px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3519\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Maud_Stevens_Wagner-2.jpeg-2.jpeg\" alt=\"10.2.1\" width=\"320\" height=\"450\" \/><figcaption id=\"caption-attachment-3519\" class=\"wp-caption-text\"><em>Figure 10.2.1 The body as a canvas.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Art for All Eras<\/h1>\n<\/div>\n<p>Pictured in Figure 10.2.1, is Maud Stevens Wagner, a tattoo artist from 1907. Tattoos are not just a late 20th and early 21st century trend. They have been popular in many eras and cultures. Tattoos literally illustrate the biggest organ of the human body: the skin. The skin is very thin, but it covers a large area \u2014 about 2 m<sup>2<\/sup>\u00a0in adults. The skin is the major organ in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2905\">integumentary system<\/a>.<\/p>\n<div>\n<h1>What Is the Integumentary System?<\/h1>\n<\/div>\n<p>In addition to the skin, the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2905\">integumentary system<\/a><\/strong>\u00a0includes the\u00a0hair\u00a0and\u00a0nails, which are organs that grow out of the skin. Because the organs of the integumentary system are mostly external to the body, you may think of them as little more than accessories, like clothing or jewelry, but they serve vital physiological functions. They provide a protective covering for the body, sense\u00a0the environment, and help the body maintain\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5761\">homeostasis<\/a>.<\/p>\n<div>\n<h1>The Skin<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3521\">skin<\/a><\/strong> is remarkable not only because it is the body\u2019s largest organ: the average square inch of skin has 20 blood vessels, 650 sweat glands, and more than 1,000 nerve endings. Incredibly, it also has 60,000 pigment-producing cells. All of these structures are packed into a stack of cells that is just 2 mm thick. Although the skin is thin, it consists of two distinct layers: the epidermis and dermis, as shown in the diagram (Figure 10.2.2).<\/p>\n<figure id=\"attachment_3522\" aria-describedby=\"caption-attachment-3522\" style=\"width: 587px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3522\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anatomy_The_Skin_-_NCI_Visuals_Online-2.jpg\" alt=\"Skin Diagram\" width=\"587\" height=\"585\" \/><figcaption id=\"caption-attachment-3522\" class=\"wp-caption-text\"><em>Figure 10.2.2 The epidermis is the thinner outer layer of skin, and the dermis is the thicker inner layer of skin. The latter contains structures such as blood vessels and sweat glands.<\/em><\/figcaption><\/figure>\n<h2>Outer Layer of Skin<\/h2>\n<p>The outer layer of skin is the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5991\">epidermis<\/a><\/strong>. This layer is thinner than the inner layer (the dermis). The epidermis consists mainly of epithelial\u00a0cells, called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3524\">keratinocytes<\/a>,<\/strong>\u00a0which produce the tough, fibrous\u00a0protein\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3525\">keratin<\/a>.<\/strong>\u00a0The innermost\u00a0cells\u00a0of the epidermis are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3163\">stem cells<\/a>\u00a0that divide continuously to form new cells. The newly formed cells move up through the epidermis toward the skin surface, while producing more and more keratin. The cells become filled with keratin and die by the time they reach the surface, where they form a protective, waterproof layer. As the dead cells are shed from the surface of the skin, they are replaced by other cells that move up from below. The epidermis also contains <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3526\"><strong>melanocytes<\/strong><\/a>, the cells that produce the brown pigment melanin, which gives skin most of its colour. Although the epidermis contains some sensory receptor cells \u2014 called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3527\">Merkel cells<\/a> \u2014 it contains no nerves, blood vessels, or other structures.<\/p>\n<h2>Inner Layer of Skin<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5967\">dermis<\/a><\/strong> is the inner, thicker layer of skin. It consists mainly of tough <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2815\">connective tissue<\/a>, and is attached to the epidermis by collagen fibres. The dermis contains many structures (as shown in Figure 10.2.2), including blood vessels, sweat glands, and hair follicles, which are structures where hairs originate. In addition, the dermis contains many sensory receptors, nerves, and oil glands.<\/p>\n<h2>Functions of the Skin<\/h2>\n<p>The skin has multiple roles in the body. Many of these roles are related to\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5761\">homeostasis<\/a>. The skin\u2019s main functions\u00a0are\u00a0preventing\u00a0water\u00a0loss from the body and serving as a barrier to the entry of microorganisms. Another function of the skin is synthesizing vitamin D, which occurs when the skin is exposed to ultraviolet (UV) light. Melanin in the epidermis blocks some of the UV light and protects the dermis from its damaging effects.<\/p>\n<p>Another important function of the skin is helping to regulate body temperature. When the body is too warm, for example, the skin lowers body temperature by producing sweat, which cools the body when it evaporates. The skin also increases the amount of blood flowing near the body surface through vasodilation (widening of blood vessels), bringing heat from the body core to radiate out into the environment. The sweaty hair and flushed skin of the young man pictured in Figure 10.2.3 reflect these skin responses to overheating.<\/p>\n<figure id=\"attachment_3529\" aria-describedby=\"caption-attachment-3529\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3529\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/shashank-shekhar-Db1J_qp_ctc-unsplash-scaled-3.jpg\" alt=\"Man Sweating\" width=\"400\" height=\"267\" \/><figcaption id=\"caption-attachment-3529\" class=\"wp-caption-text\"><em>Figure 10.2.3 Both sweating and flushing of the skin are signs that the skin is working to cool the body.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"font-size: 1.602em; font-weight: bold;\">Hair<\/span><\/p>\n<\/div>\n<figure id=\"attachment_3532\" aria-describedby=\"caption-attachment-3532\" style=\"width: 200px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3532\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Eyelashes-by-aryan-dhiman-93NBu0zG_H4-unsplash-scaled-3.jpg\" alt=\"Eyelashes\" width=\"200\" height=\"267\" \/><figcaption id=\"caption-attachment-3532\" class=\"wp-caption-text\"><em>Figure 10.2.4 Eyelashes protect the eyes.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3531\">Hair<\/a><\/strong> is a fibre found only in mammals. It consists mainly of keratin-producing <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3524\">keratinocytes<\/a>. Each hair grows out of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_6015\">follicle<\/a> in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5967\">dermis<\/a>. By the time the hair reaches the surface, it consists mainly of dead cells filled with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3525\">keratin<\/a>. Hair serves several homeostatic functions. Head hair is important in preventing heat loss from the head and protecting its skin from UV radiation. Hairs in the nose trap dust particles and microorganisms in the air, and prevent them from reaching the lungs. Hair all over the body provides sensory input when objects brush against it, or when it sways in moving air. Eyelashes and eyebrows (see Figure 10.2.4) protect the eyes from water, dirt, and other irritants.<\/p>\n<div>\n<h1>Nails<\/h1>\n<\/div>\n<p>Fingernails and toenails consist of dead <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3524\">keratinocytes<\/a> filled with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3525\">keratin<\/a>. The keratin makes them hard but flexible, which is important for the functions they serve. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5495\">Nails<\/a>\u00a0prevent injury by forming protective plates over the ends of the fingers and toes. They also enhance sensation by acting as a counterforce to the sensitive fingertips when objects are handled. In addition, the fingernails can be used as tools.<\/p>\n<div>\n<h1>Interactions with Other Organ Systems<\/h1>\n<\/div>\n<p>The skin and other parts of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2905\">integumentary system<\/a> work with other organ systems to maintain\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5761\">homeostasis<\/a>.<\/p>\n<ul>\n<li>The skin works with the immune system to defend the body from pathogens by serving as a physical barrier to microorganisms.<\/li>\n<li>Vitamin D is needed by the\u00a0digestive system\u00a0to absorb calcium from food. By synthesizing vitamin D, the skin works with the digestive system to ensure that calcium can be absorbed.<\/li>\n<li>To control body\u00a0temperature, the skin works with the\u00a0cardiovascular system\u00a0to either lose body\u00a0heat, or to conserve it through vasodilation or vasoconstriction.<\/li>\n<li>To detect certain sensations from the outside world, the\u00a0nervous system\u00a0depends on nerve receptors in the skin.<\/li>\n<\/ul>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.2 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2905\">integumentary system<\/a> consists of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3521\">skin<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3531\">hair<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5495\">nails<\/a>. Functions of the integumentary system include providing a protective covering for the body, sensing\u00a0the environment, and helping the body maintain homeostasis.<\/li>\n<li>The skin consists of two distinct layers: a thinner outer layer called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5991\">epidermis<\/a>, and a thicker\u00a0inner layer called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5967\">dermis<\/a>.<\/li>\n<li>The epidermis consists mainly of epithelial cells called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3524\">keratinocytes<\/a>, which produce <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3525\">keratin<\/a>. New keratinocytes form at the bottom of the epidermis. They become filled with keratin and die as they move upward toward the surface of the skin, where they form a protective, waterproof layer.<\/li>\n<li>The dermis consists mainly of tough <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2815\">connective tissues<\/a>\u00a0and many structures, including blood vessels, sensory receptors, nerves, hair follicles, and oil and sweat glands.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3521\">skin<\/a>\u2019s main functions\u00a0are\u00a0preventing\u00a0water\u00a0loss from the body, serving as a barrier to the entry of microorganisms, synthesizing vitamin D, blocking UV light, and helping to regulate body temperature.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3531\">Hair<\/a> consists mainly of dead keratinocytes and grows out of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_6015\">follicles<\/a>\u00a0in the dermis. Hair helps prevent heat loss from the head, and protects its skin from UV light. Hair in the nose filters incoming air, and the eyelashes and eyebrows keep harmful substances out of the\u00a0eyes. Hair all over the body provides tactile sensory input.<\/li>\n<li>Like hair, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_5495\">nails<\/a>\u00a0also consist mainly of dead keratinocytes. They help protect the ends of the fingers and toes, enhance the sense of touch in the fingertips, and may be used as tools.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.2 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Name the organs of the integumentary system.<\/li>\n<li>Compare and contrast the epidermis and dermis.<\/li>\n<li>Identify functions of the skin.<\/li>\n<li>\n<div id=\"h5p-581\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-581\" class=\"h5p-iframe\" data-content-id=\"581\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"10.1 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What is the\u00a0composition of hair?<\/li>\n<li>Describe three physiological roles played by hair.<\/li>\n<li>What do nails consist of?<\/li>\n<li>List two functions of nails.<\/li>\n<li>In terms of\u00a0composition, what do the outermost surface of the skin, the nails, and hair have in common?<\/li>\n<li>Identify two types of cells found in the epidermis of the skin. Describe their functions.<\/li>\n<li>Which structure and layer of skin does hair grow out of?<\/li>\n<li>Identify three main functions of the integumentary system. Give an example of each.<\/li>\n<li>What are two ways in which the integumentary system protects the body against UV radiation?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">10.2 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"The science of skin - Emma Bryce\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/OxPlCkTKhzY?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">The science of skin &#8211; Emma Bryce, TED-Ed, 2018.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"Why do we have to wear sunscreen? - Kevin P. Boyd\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/ZSJITdsTze0?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Why do we have to wear sunscreen? &#8211; Kevin P. Boyd, TED-Ed, 2013.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-3\" title=\"Scarification | National Geographic\" width=\"500\" height=\"375\" src=\"https:\/\/www.youtube.com\/embed\/Lfhot7tQcWs?start=1&#38;feature=oembed\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Scarification | National Geographic, 2008.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"content\" class=\"site-content\">\n<section class=\"standard post-793 chapter type-chapter status-publish hentry focusable\" data-type=\"chapter\">\n<h2>Attributions<\/h2>\n<p><strong>Figure 10.2.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Maud_Stevens_Wagner.jpeg\" rel=\"cc:attributionURL\">Maud_Stevens_Wagner <\/a>-The Plaza Gallery, Los Angeles, 1907\u00a0from the <a href=\"https:\/\/www.loc.gov\/pictures\/item\/2006687059\/\">Library of Congress<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/p>\n<p><strong>Figure 10.2.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anatomy_The_Skin_-_NCI_Visuals_Online.jpg\" rel=\"cc:attributionURL\">Anatomy_The_Skin_-_NCI_Visuals_Online<\/a> by Don Bliss (artist) from <a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a>, on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/p>\n<p><strong>Figure 10.2.3<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/Db1J_qp_ctc\" rel=\"cc:attributionURL\">shashank-shekhar-Db1J_qp_ctc<\/a> [photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@5hashank\">Shashank Shekhar<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the \u00a0<a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 10.2.4<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/93NBu0zG_H4\" rel=\"cc:attributionURL\">Eyelashes by aryan-dhiman-93NBu0zG_H4<\/a> [photo] by <a href=\"https:\/\/unsplash.com\/@mylifeasaryan_\">Aryan Dhiman<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the \u00a0<a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 1.424em; font-weight: bold; color: #333333;\">Reference<\/span><\/p>\n<\/section>\n<\/div>\n<p class=\"hanging-indent\">National Geographic. (2008). Scarification | National Geographic. YouTube. https:\/\/www.youtube.com\/watch?v=Lfhot7tQcWs&amp;t=1s<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2018, March 12). The science of skin &#8211; Emma Bryce. YouTube. https:\/\/www.youtube.com\/watch?v=OxPlCkTKhzY&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2013, August 6). Why do we have to wear sunscreen? &#8211; Kevin P. Boyd. YouTube. https:\/\/www.youtube.com\/watch?v=ZSJITdsTze0&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4862_2905\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_2905\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<div id=\"h5p-32\">\n<div class=\"h5p-content\" data-content-id=\"32\"><\/div>\n<\/div>\n<p><em>Figure 4.2.1 Human cells viewed with a very powerful tool called a scanning electron microscope.<\/em><\/p>\n<div>\n<h1>Amazing Cells<\/h1>\n<\/div>\n<p>What are these incredible objects? Would it surprise you to learn that they are all human <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2223\">cells<\/a>? Cells are actually too small to see with the unaided eye. It is visible here in such detail because it is being viewed with a very powerful\u00a0tool called a scanning electron microscope.\u00a0Cells may be small in size, but they are\u00a0<em>extremely<\/em>\u00a0important to life. Like all other living things, you are made of cells. Cells are the basis of life, and without cells, life as we know it would not exist. You will learn more about these amazing building blocks of life in this section.<\/p>\n<div>\n<h1>What Are Cells?<\/h1>\n<\/div>\n<p>If you look at living matter with a\u00a0microscope\u00a0\u2014 even a simple light microscope \u2014 you will see that it consists of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2223\">cells<\/a>. Cells are the basic units of the structure and function of living things. They are the smallest units that can carry out the processes of life. All organisms are made up of one or more cells, and all cells have many of the same structures and carry out the same basic life processes. Knowing the structure of cells and the processes they carry out is necessary to an understanding of life itself.<\/p>\n<div>\n<figure id=\"attachment_226\" aria-describedby=\"caption-attachment-226\" style=\"width: 421px\" class=\"wp-caption alignright\"><img class=\" wp-image-226\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Robert-Hookes-Diagrams.jpg\" alt=\"Diagram shows sketches from the lab journal of Robert Hooke. It includes a sketch of cork as it appeared under the microscope, a sketch of the cork tree branch his sample came from, and a sketch of the microscope apparatus he used.\" width=\"421\" height=\"247\"><figcaption id=\"caption-attachment-226\" class=\"wp-caption-text\"><em>Figure 4.2.2 Robert Hooke sketched the cork cells as they appeared under a simple light microscope.<\/em><\/figcaption><\/figure>\n<h2>Discovery of Cells<\/h2>\n<\/div>\n<p>The first time the word\u00a0<em>cell<\/em>\u00a0was used to refer to these tiny units of life was in 1665 by a British scientist named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Robert_Hooke\">Robert Hooke<\/a>.\u00a0Hooke was one of the earliest scientists to study living things under a\u00a0microscope. The microscopes of his day were not very strong, but Hooke was still able to make an important discovery. When he looked at a thin slice of cork under his microscope, he was surprised to see what looked like a honeycomb. Hooke made the drawing in the figure\u00a0to the right\u00a0to show what he saw. As you can see, the cork was made up of many tiny units. Hooke called these units\u00a0<em>cells<\/em>\u00a0because they resembled cells in a monastery.<\/p>\n<div>\n<p><span style=\"text-align: initial;font-size: 1em\">Soon after Robert Hooke discovered cells in cork, <a href=\"https:\/\/en.wikipedia.org\/wiki\/Antonie_van_Leeuwenhoek\">Anton van Leeuwenhoek<\/a> in Holland made other important discoveries using a microscope. Leeuwenhoek made his own microscope\u00a0<\/span>lenses<span style=\"text-align: initial;font-size: 1em\">, and he was so good at it that his microscope was more powerful than other microscopes of his day. In fact, Leeuwenhoek\u2019s microscope was almost as strong as\u00a0<\/span><em style=\"text-align: initial;font-size: 1em\">modern\u00a0<\/em><span style=\"text-align: initial;font-size: 1em\">light microscopes.\u00a0Using his microscope, Leeuwenhoek was the first person to observe human cells and\u00a0<\/span>bacteria<span style=\"text-align: initial;font-size: 1em\">.<\/span><\/p>\n<\/div>\n<div>\n<h2>Cell Theory<\/h2>\n<\/div>\n<p>By the early 1800s, scientists had observed cells of many different organisms. These observations led two German scientists named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Theodor_Schwann\">Theodor Schwann<\/a> and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Matthias_Jakob_Schleiden\">Matthias Jakob Schleiden<\/a> to propose\u00a0cells as\u00a0the basic building blocks of all living things. Around 1850, a German doctor named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Rudolf_Virchow\">Rudolf Virchow<\/a> was studying cells under a microscope, when he happened to see them dividing and forming new cells. He realized that living cells produce new cells through division. Based on this realization, Virchow proposed that living cells arise only from other living cells.<\/p>\n<p>The ideas of all three scientists \u2014 Schwann, Schleiden, and Virchow \u2014 led to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2302\">cell theory<\/a>, which is one of the fundamental\u00a0theories\u00a0unifying all of biology.<\/p>\n<p>Cell theory states that:<\/p>\n<ul>\n<li>All organisms are made of one or more cells.<\/li>\n<li>All the life functions of organisms occur within cells.<\/li>\n<li>All cells come from existing cells.<\/li>\n<\/ul>\n<div>\n<h2>Seeing Inside Cells<\/h2>\n<\/div>\n<p>Starting with Robert Hooke in the 1600s, the microscope opened up an amazing new world \u2014\u00a0a\u00a0world of life at the level of the cell. As microscopes continued to improve, more discoveries were made about the cells of living things, but by the late 1800s, light microscopes had reached their limit. Objects much smaller than cells (including the structures inside cells) were too small to be seen with even the strongest light microscope.<\/p>\n<figure id=\"attachment_228\" aria-describedby=\"caption-attachment-228\" style=\"width: 357px\" class=\"wp-caption alignleft\"><img class=\"wp-image-227\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Electron-Microscope-image-of-a-cell.jpg\" alt=\"\" width=\"357\" height=\"285\"><figcaption id=\"caption-attachment-228\" class=\"wp-caption-text\"><em>Figure 4.2.3 An electron microscope produced this image of the structures inside of a cell.<\/em><\/figcaption><\/figure>\n<p>Then, in the 1950s, a new type of microscope was invented. Called the\u00a0electron\u00a0microscope, it used a beam of electrons instead of light to observe extremely small objects. With an electron microscope, scientists could finally see the tiny structures inside cells. They could even see individual molecules and atoms. The electron microscope had a huge impact on biology. It allowed scientists to study organisms at the level of their molecules, and it led to the emergence of the molecular biology field. With the electron microscope, many more cell discoveries were made.<\/p>\n<div>\n<h2>Structures Shared By All Cells<\/h2>\n<\/div>\n<p>Although cells are diverse, all cells have certain parts in common. These parts include a\u00a0plasma membrane, cytoplasm, ribosomes, and\u00a0DNA.<\/p>\n<figure id=\"attachment_228\" aria-describedby=\"caption-attachment-228\" style=\"width: 447px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-228\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Basic-Components-of-a-cell.png\" alt=\"Image shows a diagram of a cell containing the four basic components of a cell: a plasma membrane, DNA, ribosomes and a cytoplasm.\" width=\"447\" height=\"344\"><figcaption id=\"caption-attachment-228\" class=\"wp-caption-text\"><em>Figure 4.2.4 Every cell consists of at least a plasma membrane, DNA, ribosomes and a cytoplasm.<\/em><\/figcaption><\/figure>\n<ol>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_1996\">plasma membrane<\/a><\/strong>\u00a0(a type of\u00a0cell membrane) is a thin coat of\u00a0lipids\u00a0that surrounds a cell. It forms the physical boundary between the cell and its environment. You can think of it as the \u201cskin\u201d of the cell.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_1963\">Cytoplasm<\/a><\/strong>\u00a0refers to all of the cellular material inside of the\u00a0plasma membrane. Cytoplasm is made up of a watery substance called cytosol, and it contains other cell structures, such as ribosomes.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2074\">Ribosomes<\/a><\/strong>\u00a0are the structures in the cytoplasm\u00a0in which\u00a0proteins\u00a0are made.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_277\">DNA<\/a><\/strong>\u00a0is a\u00a0nucleic acid\u00a0found in cells. It contains the genetic instructions that cells need to make\u00a0proteins.<\/li>\n<\/ol>\n<p>These four parts are common to\u00a0<em>all<\/em>\u00a0cells, from organisms as different as\u00a0bacteria\u00a0and human beings. How did all known organisms come to have such similar cells? The similarities show that all life on Earth has a common evolutionary history.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.2 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2223\">Cells<\/a> are the basic units of structure and function in living things. They are the smallest units that can carry out the processes of life.<\/li>\n<li>In the 1600s, Hooke was the first to observe cells from an organism (cork). Soon after, microscopist van Leeuwenhoek observed many other living cells.<\/li>\n<li>In the early 1800s, Schwann and Schleiden theorized that cells are the basic building blocks of all living things. Around 1850, Virchow\u00a0observed\u00a0cells dividing. To previous learnings, he added that living cells arise only from other living cells. These ideas led to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2302\">cell theory<\/a>, which states that all organisms are made of cells, that all life functions occur in cells, and that all cells come from other cells.<\/li>\n<li>It wasn't until the 1950s that scientists could see what was inside the cell. The invention of the\u00a0electron\u00a0microscope allowed them to see\u00a0organelles\u00a0and other structures smaller than cells.<\/li>\n<li>There is\u00a0variation in cells, but all cells have a plasma membrane, cytoplasm, ribosomes, and\u00a0DNA. These similarities show that all life on Earth has a common ancestor in the distant past.<\/li>\n<\/ul>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.2 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Describe cells.<\/li>\n<li>Explain how cells were discovered.<\/li>\n<li>Outline\u00a0the\u00a0development\u00a0of cell theory.<\/li>\n<li>\n<div id=\"h5p-33\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-33\" class=\"h5p-iframe\" data-content-id=\"33\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Cells\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Identify the structures shared by all cells.<\/li>\n<li>Proteins are made on _____________ .<\/li>\n<li>\n<div id=\"h5p-34\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-34\" class=\"h5p-iframe\" data-content-id=\"34\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Contributors to Cell Theory\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Robert Hooke sketched what looked like honeycombs \u2014 or repeated circular or square units \u2014 when he observed plant cells under a microscope.\n<ol type=\"\">\n<li>What is each unit?<\/li>\n<li>Of the shared parts of all cells, what makes up the outer surface of each unit?<\/li>\n<li>Of the shared parts of all cells, what makes up the inside of each unit?<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.2 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=8IlzKri08kk<\/p>\n<p style=\"text-align: center\">Introduction to Cells: The Grand Cell Tour, by The Amoeba Sisters, 2016.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.2.1<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=18129\">A white blood cell (WBC) known as a neutrophil<\/a> by National Institute of Allergy and Infectious Diseases (NIAID) on the CDC\/ Public Health Image Library (PHIL) Photo ID# 18129. is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/niaid\/5950870236\/\">Healthy Human T Cell\u00a0<\/a> by <a class=\"owner-name truncate\" title=\"Go to NIAID's photostream\" href=\"https:\/\/www.flickr.com\/photos\/niaid\/\" data-track=\"attributionNameClick\">NIAID<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a>. is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/niaid\/29228845335\/\">Human natural killer cell<\/a> by <a class=\"owner-name truncate\" title=\"Go to NIAID's photostream\" href=\"https:\/\/www.flickr.com\/photos\/niaid\/\" data-track=\"attributionNameClick\">NIAID<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a>. is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/zeissmicro\/14255918978\">Human blood with red blood cells, T cells (orange) and platelets (green)<\/a> by <a class=\"owner-name truncate\" title=\"Go to ZEISS Microscopy's photostream\" href=\"https:\/\/www.flickr.com\/photos\/zeissmicro\/\" data-track=\"attributionNameClick\">ZEISS Microscopy<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a>. is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/\">CC BY-NC-ND 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/zeissmicro\/14256058429\">Developing nerve cells\u00a0<\/a> by <a class=\"owner-name truncate\" title=\"Go to ZEISS Microscopy's photostream\" href=\"https:\/\/www.flickr.com\/photos\/zeissmicro\/\" data-track=\"attributionNameClick\">ZEISS Microscopy<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a>. is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/\">CC BY-NC-ND 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/) license.<\/li>\n<\/ul>\n<p><strong>Figure 4.2.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Hooke-Microscope-cork.jpg\" rel=\"cc:attributionURL\">Hooke-microscope-cork<\/a> by Robert Hooke (1635-1702) [uploaded by <a title=\"User:Alejandro Porto\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Alejandro_Porto\">Alejandro Porto]<\/a> on Wikimedia Commons is released into the <a class=\"mw-redirect\" title=\"Public domain\" href=\"https:\/\/commons.wikimedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.2.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Chlamydomonas_TEM_07.jpg\" rel=\"cc:attributionURL\">Electron Microscope image of a cell<\/a> by Dartmouth Electron Microscope Facility, Dartmouth College on Wikimedia Commons is released into the <a class=\"mw-redirect\" title=\"Public domain\" href=\"https:\/\/commons.wikimedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.2.4<\/strong><\/p>\n<p>Basic-Components-of-a-cell by Christine Miller is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"license\">CC0 1.0<\/a> (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2016, November 1). Introduction to cells: The grand cell tour. YouTube. https:\/\/www.youtube.com\/watch?v=8IlzKri08kk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">National Institute of Allergy and Infectious Diseases (NIAID). (2011). A white blood cell (WBC) known as a neutrophil, as it was in the process of ingesting a number of spheroid shaped, methicillin-resistant, Staphylococcus aureus (MRSA) bacteria [digital image]. CDC\/ Public Health Image Library (PHIL) Photo ID# 18129. https:\/\/phil.cdc.gov\/Details.aspx?pid=18129.<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 24). Antonie van Leeuwenhoek. In\u00a0<i>Wikipedia<\/i>.\u00a0 https:\/\/en.wikipedia.org\/w\/index.php?title=Antonie_van_Leeuwenhoek&amp;oldid=964339564<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, May 25). Matthias Jakob Schleiden. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Matthias_Jakob_Schleiden&amp;oldid=958819219<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 4). Rudolf Virchow. In\u00a0<i>Wikipedia,. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Rudolf_Virchow&amp;oldid=960708716<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, May 16). Theodor Schwann. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Theodor_Schwann&amp;oldid=956919239<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_5761\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_5761\"><div tabindex=\"-1\"><p>The ability of an organism to maintain constant internal conditions despite external changes.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_3521\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_3521\"><div tabindex=\"-1\"><p>visible part of a nail that is external to the skin<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_5991\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_5991\"><div tabindex=\"-1\"><p>The outer layer of skin that consists mainly of epithelial cells and lacks nerve endings, blood vessels, and other structures.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_3524\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_3524\"><div tabindex=\"-1\"><p>Acquired Immunodeficiency Syndrome - a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV). By damaging your immune system, HIV interferes with your body's ability to fight infection and disease.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_3525\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_3525\"><div tabindex=\"-1\"><p>Respiration using electron acceptors other than molecular oxygen. Although oxygen is not the final electron acceptor, the process still uses a respiratory electron transport chain.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_3163\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_3163\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4803\" aria-describedby=\"caption-attachment-4803\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4803\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Lymph-nodes-1.png\" alt=\"17.1.1 Checking Lymph Nodes\" width=\"400\" height=\"380\"><figcaption id=\"caption-attachment-4803\" class=\"wp-caption-text\"><em>Figure 17.1.1 Health practitioners will often check your lymph nodes for unusual lumps.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Case Study: Defending Your Defenses<\/h1>\n<\/div>\n<figure id=\"attachment_4807\" aria-describedby=\"caption-attachment-4807\" style=\"width: 291px\" class=\"wp-caption alignright\"><img class=\" wp-image-4807\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/mitchell-luo-ymo_yC_N_2o-unsplash-scaled-2.jpg\" alt=\"17.1.2 Hakeem\" width=\"291\" height=\"437\"><figcaption id=\"caption-attachment-4807\" class=\"wp-caption-text\"><em>Figure 17.1.2 Hakeem is concerned about his health - he has been unusually tired, has been losing weight and most recently, found an unexpected lump on the side of his neck.<\/em><\/figcaption><\/figure>\n<p>Twenty-six-year-old Hakeem wasn\u2019t feeling well. He was more tired than usual, dragging through his workdays despite going to bed earlier, and napping on the weekends. He didn\u2019t have much of an appetite, and had started losing weight. When he pressed on the side of his neck, like the doctor is doing in Figure 17.1.1, he noticed an unusual lump.<\/p>\n<p>Hakeem went to his doctor, who performed a physical exam and determined that the lump was a swollen lymph node. Lymph nodes are part of the immune system, and they will often become enlarged when the body is fighting off an infection. Dr. Hayes thinks that the swollen lymph node and fatigue could be signs of a viral or bacterial infection, although he is concerned about Hakeem\u2019s lack of appetite and weight loss. All of those symptoms combined can indicate a type of cancer called lymphoma. An infection, however, is a more likely cause, particularly in a young person like Hakeem. Dr. Hayes prescribes an antibiotic in case Hakeem has a bacterial infection, and advises him to return in a few weeks if his lymph node does not shrink, or if he is not feeling better.<\/p>\n<p>Hakeem returns a few weeks later. He is not feeling better and his lymph node is still enlarged. Dr. Hayes is concerned, and orders a biopsy of the enlarged lymph node. A lymph node biopsy for suspected lymphoma often involves the surgical removal of all or part of a lymph node. This helps to determine whether the tissue contains cancerous cells.<\/p>\n<figure id=\"attachment_4808\" aria-describedby=\"caption-attachment-4808\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4808\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lymph-node-biopsy-by-US-Army-in-Africa-on-Flickr-1.jpg\" alt=\"17.1.3 Lymph Node Biopsy\" width=\"400\" height=\"314\"><figcaption id=\"caption-attachment-4808\" class=\"wp-caption-text\"><em>Figure 17.1.3 Surgeons performing a lymph node biopsy.<\/em><\/figcaption><\/figure>\n<p>The initial results of the biopsy indicate that Hakeem does have lymphoma. Although lymphoma is more common in older people, young adults and even children can get this disease. There are many types of lymphoma, with the two main types being <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/hodgkins-lymphoma\/symptoms-causes\/syc-20352646\">Hodgkin's lymphoma<\/a> and <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/non-hodgkins-lymphoma\/symptoms-causes\/syc-20375680\">non-Hodgkin's lymphoma<\/a>. Non-Hodgkin lymphoma (NHL), in turn, has many subtypes. The subtype depends on several factors, including which cell types are affected. Some subtypes of NHL, for example, affect immune system cells called B cells, while others affect different immune system cells called T cells.<\/p>\n<p>Dr. Hayes explains to Hakeem that it is important to determine which type of lymphoma he has, in order to choose the best course of treatment. Hakeem\u2019s biopsied tissue will be further examined and tested to see which cell types are affected, as well as which specific cell-surface proteins \u2014 called antigens \u2014 are present. This should help identify his specific type of lymphoma.<\/p>\n<p>As you read this chapter, you will learn about the functions of the immune system, and the specific roles that its cells and organs \u2014 such as B and T cells and lymph nodes \u2014 play in defending the body. At the end of this chapter, you will learn what type of lymphoma Hakeem has and what some of his treatment options are, including treatments that make use of the biochemistry of the immune system to fight cancer with the immune system itself.<\/p>\n<div>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter Overview: Immune System<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In this chapter, you will learn about the immune system \u2014 the system that defends the body against infections and other causes of disease, such as cancerous cells. Specifically, you will learn about:<\/p>\n<ul>\n<li>How the immune system identifies normal cells of the body as \u201cself\u201d and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3707\">pathogens<\/a> and damaged cells as \u201cnon-self.\u201d<\/li>\n<li>The two major subsystems of the general immune system: the innate immune system \u2014 which provides a quick, but non-specific response \u2014 and the adaptive immune system, which is slower, but provides a specific response that often results in long-lasting immunity.<\/li>\n<li>The specialized immune system that protects the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3823\">brain<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3010\">spinal cord<\/a>, called the neuroimmune system.<\/li>\n<li>The organs, cells, and responses of the innate immune system, which includes physical barriers (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3521\">skin<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_4571\">mucus<\/a>), chemical and biological barriers, inflammation, activation of the complement system of molecules, and non-specific cellular responses (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_1680\">phagocytosis<\/a>).<\/li>\n<li>The lymphatic system \u2014 which includes white blood cells called lymphocytes, lymphatic vessels (which transport a fluid called lymph), and organs (such as the spleen, tonsils, and lymph nodes) \u2014 and its important role in the adaptive immune system.<\/li>\n<li>Specific cells of the immune system and their functions, including B cells, T cells, plasma cells, and natural killer cells.<\/li>\n<li>How the adaptive immune system can generate specific and often long-lasting immunity against pathogens through the production of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3567\">antibodies<\/a>.<\/li>\n<li>How vaccines work to generate immunity.<\/li>\n<li>How cells in the immune system detect and kill cancerous cells.<\/li>\n<li>Some strategies that pathogens employ to evade the immune system.<\/li>\n<li>Disorders of the immune system, including allergies, autoimmune diseases (such as diabetes and multiple sclerosis), and immunodeficiency resulting from conditions such as HIV infection.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox shaded\">\n<p>As you read the chapter, think about the following questions:<\/p>\n<ol>\n<li>What are the functions of lymph nodes?<\/li>\n<li>What are B and T cells? How do they relate to lymph nodes?<\/li>\n<li>What are cell-surface antigens? How do they relate to the immune system and to cancer?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 17.1.1<\/strong><\/p>\n<p><a href=\"https:\/\/vimeo.com\/271958333\" rel=\"cc:attributionURL\">Lymph nodes\/Is it a Cold or the Flu\u00a0<\/a> by <a href=\"https:\/\/vimeo.com\/leehealth\">Lee Health<\/a> on Vimeo is used under <a href=\"https:\/\/vimeo.com\/terms#licenses\">Vimeo's Terms of Service<\/a> (https:\/\/vimeo.com\/terms#licenses).<\/p>\n<p><strong>Figure 17.1.2<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/ymo_yC_N_2o\" rel=\"cc:attributionURL\">mitchell-luo-ymo_yC_N_2o-unsplash<\/a> [photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@mitchel3uo\">Mitchell Luo<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 17.1.3<\/strong><\/p>\n<p><a href=\"https:\/\/flic.kr\/p\/qMacvT\" rel=\"cc:attributionURL\">Lymph node biopsy<\/a> by <a class=\"owner-name truncate\" title=\"Go to US Army Africa's photostream\" href=\"https:\/\/www.flickr.com\/photos\/usarmyafrica\/\" data-track=\"attributionNameClick\">US Army Africa<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\" rel=\"license\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Hodgkin's lymphoma [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/hodgkins-lymphoma\/symptoms-causes\/syc-20352646<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Non-Hodgkin's lymphoma [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/non-hodgkins-lymphoma\/symptoms-causes\/syc-20375680<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_3526\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_3526\"><div tabindex=\"-1\"><p>Respiration using electron acceptors other than molecular oxygen. Although oxygen is not the final electron acceptor, the process still uses a respiratory electron transport chain.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_3527\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_3527\"><div tabindex=\"-1\"><p>A threadlike structure of nucleic acids and protein found in the nucleus of most living cells, carrying genetic information in the form of genes.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_5967\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_5967\"><div tabindex=\"-1\"><p>The inner layer of skin that is made of tough connective tissue and contains blood vessels, nerve endings, hair follicles, and glands.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_2815\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_2815\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<div>\n<figure id=\"attachment_3560\" aria-describedby=\"caption-attachment-3560\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-3560\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Goose_bumps.jpg\" alt=\"10.4.1\" width=\"400\" height=\"209\"><figcaption id=\"caption-attachment-3560\" class=\"wp-caption-text\"><em>Figure 10.4.1 Goose bumps!<\/em><\/figcaption><\/figure>\n<h1>Goose Bumps<\/h1>\n<\/div>\n<p>No doubt you\u2019ve experienced the tiny, hair-raising skin bumps called goose bumps, like those you see in Figure 10.4.1. They happen when you feel chilly. Do you know what causes goose bumps, or why they pop up when you are cold? The answers to these questions involve the layer of skin known as the dermis.<\/p>\n<div>\n<h1>What is the Dermis?<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2625\">dermis<\/a><\/strong>\u00a0is the inner of the two major layers that make up the skin, the outer layer being the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2655\">epidermis<\/a><\/strong>. The dermis consists mainly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2815\">connective tissues<\/a>. It also contains most skin structures, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2936\">glands<\/a>\u00a0and\u00a0blood vessels. The dermis is anchored to the tissues below it by flexible collagen bundles that permit most areas of the skin to move freely over subcutaneous (\u201cbelow the skin\u201d) tissues. Functions of the dermis include cushioning subcutaneous tissues, regulating body\u00a0temperature, sensing\u00a0the environment, and excreting wastes.<\/p>\n<div>\n<h1>Anatomy of the Dermis<\/h1>\n<\/div>\n<p>The basic anatomy of the dermis is a matrix, or sort of scaffolding, composed of connective tissues. These tissues include collagen fibres \u2014 which provide toughness \u2014 and elastin fibres, which provide elasticity. Surrounding these fibres, the matrix also includes a gel-like substance made of proteins. The tissues of the matrix give the dermis both strength and flexibility.<\/p>\n<p>The dermis is divided into two layers: the papillary layer and the reticular layer. Both layers are shown in Figure 10.4.2 below and described in the text that follows.<\/p>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 376px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-853\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Layers_of_the_Dermis.jpg\" alt=\"Layers of the Dermis\" width=\"376\" height=\"485\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.2 This photomicrograph shows a cross-section of the papillary and reticular layers of the dermis.<\/em><\/figcaption><\/figure>\n<h2>Papillary Layer<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2460\">papillary layer<\/a><\/strong> is the upper layer of the dermis, just below the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2544\">basement membrane<\/a> that connects the dermis to the epidermis above it. The papillary layer is the thinner of the two dermal layers. It is composed mainly of loosely arranged collagen fibres. The papillary layer is named for its fingerlike projections \u2014 or papillae \u2014 that extend upward into the epidermis. The papillae contain capillaries and sensory touch receptors.<\/p>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 390px\" class=\"wp-caption alignleft\"><img class=\" wp-image-3563\" src=\"http:\/\/humanbiology.pressbooks.tru.ca\/wp-content\/uploads\/sites\/6\/2019\/06\/Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d_T\u0159eb\u00ed\u010d_District.jpg#fixme\" alt=\"10.3 Fingerprints\" width=\"390\" height=\"260\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.3 This photo is an enlarged image of epidermal ridges on a finger.<\/em><\/figcaption><\/figure>\n<p>The papillae give the dermis a bumpy surface that interlocks with the epidermis above it, strengthening the connection between the two layers of skin. On the palms and soles, the papillae create epidermal ridges. Epidermal ridges on the fingers are commonly called fingerprints (see Figure 10.4.3). Fingerprints are genetically determined, so no two people (other than identical twins) have exactly the same fingerprint pattern. Therefore, fingerprints can be used as a means of identification, for example, at crime scenes. Fingerprints were much more commonly used forensically before DNA analysis was introduced for this purpose.<\/p>\n<h2>Reticular Layer<\/h2>\n<p>The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2465\"><strong>reticular layer<\/strong> <\/a>is the lower layer of the dermis, located below the papillary layer. It is the thicker of the two dermal layers. It is composed of densely woven collagen and elastin fibres. These protein fibres give the dermis its properties of strength and elasticity. This layer of the dermis cushions subcutaneous tissues of the body from stress and strain. The reticular layer of the dermis also contains most of the structures in the dermis, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2936\">glands<\/a> and hair <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2684\">follicle<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">.<\/span><\/p>\n<div>\n<h1>Structures in the Dermis<\/h1>\n<\/div>\n<p>Both papillary and reticular layers of the dermis contain numerous <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3006\">sensory receptors<\/a>, which make the skin the body\u2019s primary sensory organ for the sense of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3129\">touch<\/a>. Both dermal layers also contain blood vessels. They provide nutrients to remove wastes from dermal cells, as well as cells in the lowest layer of the epidermis, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3542\">stratum basale<\/a>. The circulatory components of the dermis are shown in Figure 10.4.4 below.<\/p>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-854\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0802_Skin_DermalCirculation.png\" alt=\"10.3 Dermal Circulation\" width=\"1024\" height=\"819\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.4 Both the papillary layer and the reticular layer of the dermis contain blood vessels, as shown in this diagram.<\/em><\/figcaption><\/figure>\n<h2>Glands<\/h2>\n<p>Glands in the reticular layer of the dermis include sweat glands and sebaceous (oil) glands. Both are exocrine glands, which are glands that release their secretions through ducts to nearby body surfaces. The diagram in Figure 10.4.5 shows these glands, as well as several other structures in the dermis.<\/p>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 702px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-856 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anatomy_The_Skin_-_NCI_Visuals_Online-1-e1591224136617.jpg\" alt=\"10.4 Skin Glands\" width=\"702\" height=\"580\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.5 The dermis contains sweat and oil (sebaceous) glands, as well as hair follicles and blood vessels.<\/em><\/figcaption><\/figure>\n<h3>Sweat Glands<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3566\">Sweat glands<\/a><\/strong>\u00a0produce the fluid called sweat, which contains mainly\u00a0water\u00a0and salts. The glands have ducts that carry the sweat to\u00a0hair\u00a0follicles, or to the surface of the skin. There are two different types of sweat glands: eccrine glands and apocrine glands.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3568\">Eccrine sweat gland<strong>s<\/strong><\/a><\/strong>\u00a0occur in skin all over the body. Their ducts empty through tiny openings called pores onto the skin surface. These sweat glands are involved in\u00a0temperature\u00a0regulation.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3569\">Apocrine sweat gland<strong>s<\/strong><\/a><\/strong>\u00a0are larger than eccrine glands, and occur only in the skin of the armpits and groin. The ducts of apocrine glands empty into hair follicles, and then the sweat travels along hairs to reach the surface. Apocrine glands are inactive until\u00a0puberty, at which point they start producing an oily sweat that is consumed by\u00a0bacteria\u00a0living on the skin. The digestion of apocrine sweat by bacteria\u00a0causes\u00a0body odor.<\/li>\n<\/ul>\n<h3>Sebaceous Glands<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3570\">Sebaceous gland<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0are exocrine glands that produce a thick, fatty substance called sebum.\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3571\">Sebum<\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0is secreted into hair follicles and makes its way to the skin surface along hairs. It waterproofs the hair and skin, and helps prevent them from drying out. Sebum also has antibacterial properties, so it inhibits the growth of microorganisms on the skin. Sebaceous glands are found in every part of the skin \u2014 except for the palms of the hands and soles of the feet, where hair does not grow.<\/span><\/p>\n<h2>Hair Follicles<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3572\">Hair follicle<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0are the structures where hairs originate (see the diagram\u00a0above). Hairs grow out of follicles, pass through the epidermis, and exit at the surface of the skin. Associated with each hair follicle is a sebaceous gland, which secretes sebum that coats and waterproofs the hair. Each follicle also has a bed of capillaries, a nerve ending, and a tiny muscle called an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2454\">arrector pili<\/a>.<\/span><\/p>\n<div>\n<h1>Functions of the Dermis<\/h1>\n<\/div>\n<p>The main functions of the dermis are regulating body temperature, enabling the sense of touch, and eliminating wastes from the body.<\/p>\n<h2>Temperature Regulation<\/h2>\n<p>Several structures in the reticular layer of the dermis are involved in regulating body temperature. For example, when body temperature rises, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2937\">hypothalamus<\/a> of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2554\">brain<\/a> sends nerve signals to sweat glands, causing them to release sweat. An adult can sweat up to four litres an hour. As the sweat evaporates from the surface of the body, it uses energy in the form of body heat, thus cooling the body. The hypothalamus also causes dilation of blood vessels in the dermis when body temperature rises. This allows more blood to flow through the skin, bringing body heat to the surface, where it can radiate into the environment.<\/p>\n<p>When the body is too cool, sweat glands stop producing sweat, and blood vessels in the skin constrict, thus conserving body\u00a0heat. The arrector pili\u00a0muscles\u00a0also contract, moving hair follicles and lifting hair shafts. This results in more air being trapped under the hairs to insulate the surface of the skin. These contractions of arrector pili muscles are the cause of goose bumps.<\/p>\n<h2>Sensing\u00a0the Environment<\/h2>\n<p>Sensory receptors in the dermis are mainly responsible for the body\u2019s tactile\u00a0senses. The receptors detect such tactile stimuli as warm or cold temperature, shape, texture, pressure, vibration, and pain. They send\u00a0nerve impulses\u00a0to the brain, which interprets and responds to the sensory information. Sensory receptors in the dermis can be classified on the basis of the type of touch stimulus they sense.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3124\">Mechanoreceptor<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0sense mechanical forces such as pressure, roughness, vibration, and stretching.\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3125\">Thermoreceptor<\/strong><strong style=\"font-size: 1em;text-align: initial\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0sense variations in temperature that are above or below body temperature.\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3126\">Nociceptor<\/strong><strong style=\"font-size: 1em;text-align: initial\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\"> sense painful stimuli. Figure 10.4.6 shows several specific kinds of tactile receptors in the dermis. Each kind of receptor senses one or more types of touch stimuli.<\/span><\/p>\n<ul>\n<li>Free nerve endings sense pain and temperature variations.<\/li>\n<li>Merkel\u00a0cells\u00a0sense light touch, shapes, and textures.<\/li>\n<li>Meissner\u2019s corpuscles sense light touch.<\/li>\n<li>Pacinian corpuscles sense pressure and vibration.<\/li>\n<li>Ruffini corpuscles sense stretching and sustained pressure.<\/li>\n<\/ul>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 836px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-858 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0809_Skin_TactileReceptors-e1591224860583.png\" alt=\"10.4 Tactile Receptors\" width=\"836\" height=\"669\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.6 A variety of types of tactile receptors are located in the dermis of the skin.<\/em><\/figcaption><\/figure>\n<h2>Excreting Wastes<\/h2>\n<p>The sweat released by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3568\">eccrine sweat gland<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0is one way the body excretes waste products. Sweat contains excess\u00a0water, salts (electrolytes), and other waste products that the body must get rid of to maintain\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2350\">homeostasis<\/a>. The most common electrolytes in sweat are sodium and chloride. Potassium, calcium, and magnesium electrolytes may be excreted in sweat, as well. When these electrolytes reach high levels in the\u00a0blood, more are excreted in sweat. This helps to bring their blood levels back into balance. Besides electrolytes, sweat contains small amounts of waste products from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2368\">metabolism<\/a>, including ammonia and urea. Sweat may also contain alcohol in someone who has been drinking alcoholic beverages.<\/span><\/p>\n<div>\n<h1>Feature: My\u00a0Human Body<\/h1>\n<\/div>\n<figure id=\"attachment_861\" aria-describedby=\"caption-attachment-861\" style=\"width: 343px\" class=\"wp-caption alignright\"><img class=\"wp-image-861\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Akne-jugend.jpg\" alt=\"10.4.7\" width=\"343\" height=\"234\"><figcaption id=\"caption-attachment-861\" class=\"wp-caption-text\"><em>Figure 10.4.7 Acne can be embarrassing, but most people will experience it at one point in their lives.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3576\">Acne<\/a><\/strong> is the most common skin disorder in the Canada. At least 20% of Canadians have acne at any given time and it affects approximately 90% of adolescents (as in Figure 10.4.7). Although acne occurs most commonly in teens and young adults, but it can occur at any age. Even newborn babies can get acne.<\/p>\n<p>The main sign of acne is the appearance of pimples (pustules) on the skin, like those in the photo above. Other signs of acne may include whiteheads, blackheads, nodules, and other lesions. Besides the face, acne can appear on the back, chest, neck, shoulders, upper arms, and buttocks. Acne can permanently scar the skin, especially if it isn\u2019t treated appropriately. Besides its physical effects on the skin, acne can also lead to low self-esteem and depression.<\/p>\n<p>Acne is caused by clogged, sebum-filled pores that provide a perfect environment for the growth of\u00a0bacteria. The bacteria cause infection, and the immune system responds with inflammation. Inflammation, in turn, causes swelling and redness, and may be associated with the formation of pus. If the inflammation goes deep into the skin, it may form an acne nodule.<\/p>\n<p>Mild acne often responds well to treatment with over-the-counter (OTC) products containing benzoyl peroxide or salicylic\u00a0acid. Treatment with these products may take a month or two to clear up the acne. Once the skin clears, treatment generally needs to continue for some time to prevent future breakouts.<\/p>\n<p>If acne fails to respond to OTC products, nodules develop, or acne is affecting self-esteem, a visit to a dermatologist is in order. A dermatologist can determine which treatment is best for a given patient. A dermatologist can also prescribe prescription medications (which are likely to be more effective than OTC products) and provide other medical treatments, such as laser light therapies or chemical peels.<\/p>\n<p>What can you do to maintain healthy skin and prevent or reduce acne? Dermatologists recommend the following tips:<\/p>\n<ul>\n<li>Wash affected or acne-prone skin (such as the face) twice a day, and after sweating.<\/li>\n<li>Use your fingertips to apply a gentle, non-abrasive cleanser. Avoid scrubbing, which can make acne worse.<\/li>\n<li>Use only alcohol-free products and avoid any products that irritate the skin, such as harsh astringents or exfoliants.<\/li>\n<li>Rinse with lukewarm\u00a0water, and avoid using very hot or cold water.<\/li>\n<li>Shampoo your hair regularly.<\/li>\n<li>Do not pick, pop, or squeeze acne. If you do, it will take longer to heal and is more likely to scar.<\/li>\n<li>Keep your hands off your face. Avoid touching your skin throughout the day.<\/li>\n<li>Stay out of the\u00a0sun\u00a0and tanning beds. Some acne medications make your skin very sensitive to UV light.<\/li>\n<\/ul>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">10.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2625\">dermis<\/a> is the inner and thicker of the two major layers that make up the skin. It consists mainly of a matrix of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2815\">connective tissue<\/a>s that provide strength and stretch. It also contains almost all skin structures, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_3006\">sensory receptors<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2448\">blood vessel<\/a>s.<\/li>\n<li>The dermis has two layers. The upper <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2460\">papillary layer<\/a> has papillae extending upward into the epidermis and loose connective tissues. The lower <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2465\">reticular layer<\/a> has denser connective tissues and structures, such as glands and hair follicles. Glands in the dermis include eccrine and apocrine sweat glands and sebaceous glands. Hair <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4862_2684\">follicles<\/a>\u00a0are structures where hairs originate.<\/li>\n<li>Functions of the dermis include cushioning subcutaneous tissues, regulating body temperature, sensing the environment, and excreting wastes. The dense connective tissues of the dermis provide cushioning. The dermis regulates body temperature mainly by sweating and by vasodilation or vasoconstriction. The many tactile sensory receptors in the dermis make it the main organ for the sense of touch. Wastes excreted in sweat include excess water, electrolytes, and certain metabolic wastes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">10.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is the dermis?<\/li>\n<li>Describe the basic anatomy of the dermis.<\/li>\n<li>Compare and contrast the papillary and reticular layers of the dermis.<\/li>\n<li>What causes epidermal ridges, and why can they be used to identify individuals?<\/li>\n<li>Name the two types of sweat glands in the dermis, and explain\u00a0how they differ.<\/li>\n<li>What is the function of sebaceous glands?<\/li>\n<li>Describe the structures associated with hair follicles.<\/li>\n<li>Explain how the dermis helps regulate body temperature.<\/li>\n<li>Identify three specific kinds of tactile receptors in the dermis, along with the type of stimuli they sense.<\/li>\n<li>How does the dermis excrete wastes? What waste products does it excrete?<\/li>\n<li>What are subcutaneous tissues?\u00a0Which layer of the dermis provides cushioning for subcutaneous tissues? Why does this layer provide most of the cushioning, instead of the other layer?<\/li>\n<li>For each of the functions listed below, describe which structure within the dermis carries it out.\n<ol type=\"a\">\n<li>Brings nutrients to and removes wastes from dermal and lower epidermal cells<\/li>\n<li>Causes hairs to move<\/li>\n<li>Detects painful stimuli on the skin<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">10.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE<\/p>\n<p style=\"text-align: center\">How do you get rid of acne? SciShow, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">When You Can't Scratch Away An Itch, Seeker, 2013.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 10.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Goose_bumps.jpg\" rel=\"cc:attributionURL\">Goose_bumps<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/photos\/61532128@N00\" rel=\"nofollow\">EverJean<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 10.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:506_Layers_of_the_Dermis.jpg\" rel=\"cc:attributionURL\">Layers_of_the_Dermis<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 10.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Fingerprint_detail_on_male_finger_in_T%C5%99eb%C3%AD%C4%8D,_T%C5%99eb%C3%AD%C4%8D_District.jpg\" rel=\"cc:attributionURL\">Fingerprint_detail_on_male_finger_in_T\u0159eb\u00ed\u010d,_T\u0159eb\u00ed\u010d_District<\/a> by <a title=\"User:Frettie\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Frettie\">Frettie<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong style=\"text-align: initial;font-size: 1em\">Figure 10.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0802_Skin_DermalCirculation.png\" rel=\"cc:attributionURL\">Blausen_0802_Skin_Dermal Circulation<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial;font-size: 1em\">\u00a0<a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anatomy_The_Skin_-_NCI_Visuals_Online.jpg\" rel=\"cc:attributionURL\">Anatomy_The_Skin_-_NCI_Visuals_Online<\/a>\u00a0by Don Bliss (artist) \/ \u00a0<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a class=\"extiw\" title=\"en:National Institutes of Health\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Institutes_of_Health\">National Institutes of Health<\/a>, with the ID\u00a0<a class=\"external text\" href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4604\" rel=\"nofollow\">4604<\/a>) is in the<span style=\"font-size: 1em\"> <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain).<\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0809_Skin_TactileReceptors.png\" rel=\"cc:attributionURL\">Blausen_0809_Skin_TactileReceptors<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia commons is used under a <span style=\"text-align: initial;font-size: 1em\">\u00a0<a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 10.4.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Akne-jugend.jpg\" rel=\"cc:attributionURL\">Akne-jugend<\/a> by <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> <span style=\"font-size: 1em\">(https:\/\/en.wikipedia.org\/wiki\/public_domain)<\/span>. (No machine-readable author provided. <a title=\"User:Ellywa\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Ellywa\">Ellywa<\/a>\u00a0assumed, based on copyright claims).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure 5.7 Layers of the dermis [digital image]. In <em>Anatomy and Physiology<\/em> (Section 5.1 Layers of the skin). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/5-1-layers-of-the-skin<\/p>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">SciShow. (2016, October 26). How do you get rid of acne? YouTube. https:\/\/www.youtube.com\/watch?v=FX-FwK0IIrE<\/p>\n<p class=\"hanging-indent\">Seeker. (2013, October 26). When you can't scratch away an itch. YouTube. https:\/\/www.youtube.com\/watch?v=VcHQWMAClhQ&amp;amp;feature=emb_logo<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_3531\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_3531\"><div tabindex=\"-1\"><p>a colorless cell that circulates in the blood and body fluids and is involved in counteracting foreign substances and disease; a white (blood) cell. There are several types, all amoeboid cells with a nucleus, including lymphocytes, granulocytes, monocytes, and macrophages.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_6015\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_6015\"><div tabindex=\"-1\"><p>An anatomical structure that consists of a small cluster of cells, surrounding a central cavity.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4862_5495\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4862_5495\"><div tabindex=\"-1\"><p>accessory organ of the skin made of sheets of dead keratinocytes at the distal ends of the fingers and toes<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"author":32,"menu_order":2,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":"cc-by-nc"},"chapter-type":[48],"contributor":[],"license":[55],"class_list":["post-4862","chapter","type-chapter","status-publish","hentry","chapter-type-numberless","license-cc-by-nc"],"part":4853,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/users\/32"}],"version-history":[{"count":4,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4862\/revisions"}],"predecessor-version":[{"id":6451,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4862\/revisions\/6451"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/parts\/4853"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4862\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/media?parent=4862"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapter-type?post=4862"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/contributor?post=4862"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/license?post=4862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}