{"id":4815,"date":"2019-06-24T14:57:00","date_gmt":"2019-06-24T14:57:00","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/11-2-introduction-to-the-endocrine-system-3\/"},"modified":"2023-11-30T18:52:10","modified_gmt":"2023-11-30T18:52:10","slug":"11-2-introduction-to-the-endocrine-system-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/11-2-introduction-to-the-endocrine-system-3\/","title":{"raw":"9.2\u00a0Introduction to the Endocrine System","rendered":"9.2\u00a0Introduction to the Endocrine System"},"content":{"raw":"&nbsp;\r\n<div>\r\n\r\n[caption id=\"attachment_3397\" align=\"aligncenter\" width=\"674\"]<img class=\"wp-image-3397\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Steroidogenesis.svg_-2.png\" alt=\"\" width=\"674\" height=\"598\" \/> <em>Figure 9.2.1 Enzymes, their cellular location, substrates and products in human steroidogenesis. <\/em>[\/caption]\r\n<h1>Your body the chemist<\/h1>\r\n<\/div>\r\nYour endocrine system is constantly making hormones that will regulate every body system that makes up you!\u00a0 The endocrine system is an adept chemist; by making a chain of modifications to the steroid cortisol, your body can make a whole host of other hormones at a moment's notice.\r\n<div>\r\n<h1>Overview of the Endocrine System<\/h1>\r\n<\/div>\r\nThe\u00a0<strong>[pb_glossary id=\"5985\"]endocrine system[\/pb_glossary]<\/strong>\u00a0is a system of glands called\u00a0endocrine glands\u00a0that release chemical messenger molecules into the bloodstream. The messenger molecules of the endocrine system are called\u00a0endocrine hormones. Other glands of the body, including sweat glands and salivary glands, also secrete substances, but not into the bloodstream. Instead, they secrete them through ducts that carry them to nearby body surfaces. These other glands are not part of the endocrine system. Instead, they are called\u00a0<strong>[pb_glossary id=\"6001\"]exocrine glands[\/pb_glossary].<\/strong>\r\n\r\nEndocrine hormones\u00a0act slowly compared with the rapid transmission of electrical messages in the\u00a0nervous system. Endocrine hormones must travel through the bloodstream to the\u00a0cells\u00a0they affect, and this takes time. On the other hand, because endocrine hormones are released into the bloodstream, they travel throughout the body wherever\u00a0blood\u00a0flows. As a result, endocrine hormones may affect many cells and have body-wide effects. The effects of endocrine hormones are also longer lasting than the effects of nervous system messages. Endocrine hormones may cause effects that last for days, weeks, or even months.\r\n<div>\r\n<h1>Glands of the Endocrine System<\/h1>\r\n<\/div>\r\nThe major glands of the endocrine system are shown in Figure 9.2.2. The glands in the figure are described briefly in the rest of this section. Refer to the figure as you read about the glands in the following text.\r\n\r\n[caption id=\"attachment_3399\" align=\"alignnone\" width=\"928\"]<img class=\"wp-image-3399 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/1801_The_Endocrine_System-2.jpg\" alt=\"The Endocrine System\" width=\"928\" height=\"831\" \/> <em>Figure 9.2.2 The endocrine system. <\/em>[\/caption]\r\n\r\n<div>\r\n\r\nAll of the glands labelled in Figure 9.2.2 are part of the endocrine system. Note that the ovary and testis are the only endocrine glands that differ in males and females.\r\n\r\n<\/div>\r\n<h2>Pituitary Gland<\/h2>\r\nThe [pb_glossary id=\"2938\"]<strong>pituitary gland<\/strong>[\/pb_glossary] is located at the\u00a0base\u00a0of the [pb_glossary id=\"5915\"]brain[\/pb_glossary]. It is controlled by the\u00a0[pb_glossary id=\"2908\"]nervous system[\/pb_glossary]\u00a0via the brain structure called the [pb_glossary id=\"2937\"]hypothalamus[\/pb_glossary], to which it is connected by a thin stalk. The pituitary gland consists of two lobes, called the [pb_glossary id=\"5889\"]anterior[\/pb_glossary] (front) lobe and [pb_glossary id=\"3401\"]posterior[\/pb_glossary] (back) lobe. The posterior lobe stores and secretes [pb_glossary id=\"5661\"]hormones[\/pb_glossary] synthesized by the hypothalamus. The anterior lobe synthesizes and secretes its own endocrine hormones, also under the influence of the hypothalamus. One endocrine\u00a0hormone\u00a0secreted by the pituitary gland is growth hormone, which stimulates\u00a0cells\u00a0throughout the body to synthesize\u00a0proteins\u00a0and divide. Most of the other endocrine hormones secreted by the pituitary gland control other\u00a0endocrine glands. Generally, these hormones direct the other glands to secrete either more or less of their hormones, which is why the pituitary gland is often referred to as the \u201cmaster gland\u201d of the endocrine system.\r\n<h2>Remaining Glands of the Endocrine System<\/h2>\r\nEach of the other glands of the endocrine system is summarized below. Several of these endocrine glands are also discussed in greater detail in other concepts in this chapter.\r\n<ul>\r\n \t<li>The\u00a0[pb_glossary id=\"2958\"]<strong>thyroid gland<\/strong>[\/pb_glossary]\u00a0is a large gland in the neck. Thyroid hormones (such as thyroxine) increase the rate of metabolism in\u00a0cells\u00a0throughout the body. They control how quickly cells use\u00a0energy\u00a0and make\u00a0proteins.<\/li>\r\n \t<li>The four\u00a0<strong>[pb_glossary id=\"3402\"]parathyroid glands[\/pb_glossary]<\/strong>\u00a0are located in the neck behind the\u00a0thyroid gland. Parathyroid\u00a0hormone\u00a0helps keep the level of calcium in the\u00a0[pb_glossary id=\"2702\"]blood[\/pb_glossary]\u00a0within a narrow range. It stimulates bone cells to dissolve calcium and release it into the blood.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3403\"]pineal gland[\/pb_glossary]<\/strong> is a tiny gland located near the center of the brain. It secretes the hormone [pb_glossary id=\"3404\"]melatonin[\/pb_glossary], which controls the sleep-wake cycle and several other processes. The production of melatonin is stimulated by darkness and inhibited by light. Cells in the retina of the eye detect light and send signals to a structure in the brain called the suprachiasmatic nucleus (SCN). Nerve fibres carry the signals from the SCN to the pineal gland via the autonomic nervous system.<\/li>\r\n \t<li>The\u00a0[pb_glossary id=\"3197\"]pancreas[\/pb_glossary]\u00a0is located near the stomach. Its endocrine hormones include [pb_glossary id=\"2590\"]insulin[\/pb_glossary] and [pb_glossary id=\"6043\"]glucagon[\/pb_glossary], which work together to control the level of [pb_glossary id=\"5451\"]glucose[\/pb_glossary] in the blood. The pancreas also secretes digestive [pb_glossary id=\"5757\"]enzymes[\/pb_glossary]\u00a0into the small intestine.<\/li>\r\n \t<li>The two\u00a0[pb_glossary id=\"5869\"]adrenal glands[\/pb_glossary]\u00a0are located above the\u00a0[pb_glossary id=\"2988\"]kidneys[\/pb_glossary]. Adrenal glands secrete several different endocrine hormones, including the hormone [pb_glossary id=\"5875\"]adrenaline[\/pb_glossary], which is involved in the [pb_glossary id=\"6013\"]fight-or-flight response[\/pb_glossary]. Other endocrine hormones secreted by the adrenal glands have a variety of functions. The hormone [pb_glossary id=\"5881\"]aldosterone[\/pb_glossary], for example, helps regulate the balance of minerals in the body. The hormone\u00a0<strong>[pb_glossary id=\"5959\"]cortisol[\/pb_glossary]<\/strong>\u00a0is also an adrenal gland hormone.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3408\"]gonads[\/pb_glossary]<\/strong>\u00a0include the ovaries in females and the testes in males. They secrete sex hormones,\u00a0including\u00a0[pb_glossary id=\"3409\"]testosterone[\/pb_glossary] (in males) and [pb_glossary id=\"5995\"]estrogen[\/pb_glossary] and [pb_glossary id=\"3411\"]progesterone[\/pb_glossary] (in females). These hormones control sexual maturation during puberty and the production of gametes (sperm or egg cells) by the gonads after sexual maturation.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3412\"]thymus gland[\/pb_glossary]<\/strong> is located in front of the heart. It is the site where immune system cells, called T cells, mature. T cells are critical to the adaptive immune system, in which the body adapts to specific pathogens.<\/li>\r\n<\/ul>\r\n<div>\r\n<h1>Endocrine System Disorders<\/h1>\r\n<\/div>\r\nDiseases of the endocrine system are relatively common. An endocrine system disease usually involves the secretion of too much or not enough of a hormone. When too much hormone is secreted, the condition is called\u00a0<strong>[pb_glossary id=\"3413\"]hypersecretion[\/pb_glossary].<\/strong>\u00a0When not enough hormone is secreted, the condition is called\u00a0<strong>[pb_glossary id=\"3414\"]hyposecretion[\/pb_glossary].<\/strong>\r\n<h2>Hypersecretion and Hyposecretion<\/h2>\r\n[caption id=\"attachment_3416\" align=\"alignright\" width=\"253\"]<img class=\"size-full wp-image-3416\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/MartinVanBurenBates-2.jpeg\" alt=\"Gigamtism\" width=\"253\" height=\"420\" \/> <em>Figure 9.2.3 The man on the left, named Martin Van Buren Bates, is depicted in this photo standing next to a man of average size. Bates was a Civil War-era American famed for his incredibly large size. He was at least 7 feet 9 inches tall and weighed close to 500 pounds. He was normal in size at birth, but started to grow very rapidly by about age six years, presumably because of hypersecretion of growth hormone.<\/em>[\/caption]\r\n\r\nHypersecretion by an endocrine gland is often caused by a [pb_glossary id=\"1984\"]tumor[\/pb_glossary]. A tumor of the pituitary gland, for example, can cause hypersecretion of [pb_glossary id=\"3415\"]growth hormone[\/pb_glossary]. If this occurs during childhood and goes untreated, it results in very long arms and legs, and an abnormally tall stature by adulthood (see Figure 9.2.3). This condition is commonly known as gigantism.\r\n<div>\r\n\r\n<span style=\"text-align: initial; font-size: 1em;\">Hyposecretion by an endocrine gland is often caused by destruction of the hormone-secreting cells of the gland. As a result, not enough of the hormone is secreted. An example of this is type 1 diabetes, in which the body\u2019s own immune system attacks and destroys cells of the pancreas that secrete insulin. This type of diabetes is generally treated with frequent injections of insulin.<\/span>\r\n\r\n<\/div>\r\n<h2>Hormone\u00a0Resistance<\/h2>\r\nIn some cases, an endocrine gland secretes a normal amount of hormone, but target cells do not respond normally to it. This may occur because target cells have become resistant to the hormone. An example of this type of endocrine disorder is [pb_glossary id=\"3417\"]type 2\u00a0diabetes[\/pb_glossary]. In type 2 diabetes,\u00a0body cells\u00a0do not respond to normal amounts of insulin. As a result, cells do not take up glucose from the blood, leading to high blood glucose levels. Insulin may or may not be needed to treat type 2 diabetes. Instead, it may be treated with lifestyle changes and non-insulin medications.\r\n<div>\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">9.2 Summary<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul>\r\n \t<li>The [pb_glossary id=\"5985\"]endocrine system[\/pb_glossary] is a system of glands that release chemical messenger molecules called [pb_glossary id=\"5661\"]hormones[\/pb_glossary] into the bloodstream. Other glands, called [pb_glossary id=\"6001\"]exocrine glands[\/pb_glossary], release substances onto nearby body surfaces through ducts. Endocrine hormones travel more slowly than\u00a0nerve impulses, which are the body\u2019s other way of sending messages.\u00a0The effects of endocrine hormones, however, may be much longer lasting.<\/li>\r\n \t<li>The [pb_glossary id=\"2938\"]pituitary gland[\/pb_glossary] is the master gland of the endocrine system. Most of the hormones it produces control other endocrine glands. These glands include the\u00a0[pb_glossary id=\"2958\"]thyroid gland[\/pb_glossary], [pb_glossary id=\"3402\"]parathyroid glands[\/pb_glossary], [pb_glossary id=\"3403\"]pineal gland[\/pb_glossary], [pb_glossary id=\"3197\"]pancreas[\/pb_glossary],\u00a0[pb_glossary id=\"5869\"]adrenal glands[\/pb_glossary], gonads (testes and ovaries), and [pb_glossary id=\"3412\"]thymus gland[\/pb_glossary].<\/li>\r\n \t<li>Diseases of the endocrine system are relatively common. An endocrine disease usually involves [pb_glossary id=\"3413\"]hypersecretion[\/pb_glossary] or [pb_glossary id=\"3414\"]hyposecretion[\/pb_glossary] of a hormone. Hypersecretion is frequently caused by a tumor. Hyposecretion is often caused by destruction of hormone-secreting cells by the body\u2019s own immune system.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">9.2 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ol>\r\n \t<li>What is the endocrine system? What is its general function?<\/li>\r\n \t<li>[h5p id=\"570\"]<\/li>\r\n \t<li>[h5p id=\"571\"]<\/li>\r\n \t<li>Describe the role of the pituitary gland in the endocrine system.<\/li>\r\n \t<li>List three endocrine glands other than the pituitary gland. Identify their functions.<\/li>\r\n \t<li>Which endocrine gland has an important function in the immune system? What is that function?<\/li>\r\n \t<li>Name an endocrine disorder in which too much of a hormone is produced.<\/li>\r\n \t<li>What are two reasons people with\u00a0diabetes\u00a0might have signs and symptoms of inadequate insulin?<\/li>\r\n \t<li>Besides location, what is the main difference between the anterior lobe of the pituitary and the posterior lobe of the pituitary?<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">9.2 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=-SPRPkLoKp8\r\n<p style=\"text-align: center;\">How do your hormones work? - Emma Bryce, TED-Ed, 2018.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=-gNj5KoWLhE&amp;feature=emb_title\r\n<p style=\"text-align: center;\">What is congenital adrenal hyperplasia (CAH), Bijniervereniging NVACP, 2014.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=V48M5j-6zdE\r\n<p style=\"text-align: center;\">Cynthia Kenyon: Experiments that hint of longer lives, TED, 2011.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n&nbsp;\r\n\r\n<\/div>\r\n<h2>Attributions<\/h2>\r\n<strong>Figure 9.2.1<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Steroidogenesis.svg\" rel=\"cc:attributionURL\">Steroidogenesis.svg<\/a> by David Richfield (<a title=\"User:Slashme\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Slashme\">User:Slashme<\/a>) and <a title=\"User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m <\/a>on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\" rel=\"license\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en) [Derived from previous version by Hoffmeier and Settersr]\r\n\r\n<strong>Figure 9.2.2<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:1801_The_Endocrine_System.jpg\" rel=\"cc:attributionURL\">1801_The_Endocrine_System<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/17-1-an-overview-of-the-endocrine-system\">OpenStax College<\/a>\u00a0 on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.\r\n\r\n<strong>Figure 9.2.3<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:MartinVanBurenBates.jpeg\" rel=\"cc:attributionURL\">MartinVanBurenBates<\/a> by unknown on Wikimedia Commons is believed to be in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a><i><b>.\u00a0<\/b><\/i>\r\n\r\n&nbsp;\r\n<h2>References<\/h2>\r\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text\" data-timestamp=\"1595965908936\" data-highlight-id=\"04a04a28-30d4-4c52-85fa-79509148c52c\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure <\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text\" data-timestamp=\"1595965908936\" data-highlight-id=\"04a04a28-30d4-4c52-85fa-79509148c52c\" data-highlighted=\"true\">17.2<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"98204\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text\" data-timestamp=\"1595965908936\" data-highlight-id=\"04a04a28-30d4-4c52-85fa-79509148c52c\" data-highlighted=\"true\">Endocrine system [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 17.1). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/17-1-an-overview-of-the-endocrine-system<\/span><\/span><\/p>\r\n<p class=\"hanging-indent\">Bijniervereniging NVACP. (2014, October 11). What is congenital adrenal hyperplasia (CAH)? YouTube. https:\/\/www.youtube.com\/watch?v=-gNj5KoWLhE&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">H\u00e4ggstr\u00f6m M, Richfield D (2014). Diagram of the pathways of human steroidogenesis. <i>WikiJournal of Medicine<\/i>\u00a0<b>1<\/b>\u00a0(1).\u00a0DOI:10.15347\/wjm\/2014.005.\u00a0ISSN\u00a020024436 [Derived from previous version by Hoffmeier and Settersr]<\/p>\r\n<p class=\"hanging-indent\">TED. (2011, November 17). Cynthia Kenyon: Experiments that hint of longer lives. YouTube. https:\/\/www.youtube.com\/watch?v=V48M5j-6zdE&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2018, June 21). How do your hormones work? - Emma Bryce. YouTube. https:\/\/www.youtube.com\/watch?v=-SPRPkLoKp8&amp;feature=youtu.be<\/p>\r\n&nbsp;","rendered":"<p>&nbsp;<\/p>\n<div>\n<figure id=\"attachment_3397\" aria-describedby=\"caption-attachment-3397\" style=\"width: 674px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3397\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Steroidogenesis.svg_-2.png\" alt=\"\" width=\"674\" height=\"598\" \/><figcaption id=\"caption-attachment-3397\" class=\"wp-caption-text\"><em>Figure 9.2.1 Enzymes, their cellular location, substrates and products in human steroidogenesis. <\/em><\/figcaption><\/figure>\n<h1>Your body the chemist<\/h1>\n<\/div>\n<p>Your endocrine system is constantly making hormones that will regulate every body system that makes up you!\u00a0 The endocrine system is an adept chemist; by making a chain of modifications to the steroid cortisol, your body can make a whole host of other hormones at a moment&#8217;s notice.<\/p>\n<div>\n<h1>Overview of the Endocrine System<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5985\">endocrine system<\/a><\/strong>\u00a0is a system of glands called\u00a0endocrine glands\u00a0that release chemical messenger molecules into the bloodstream. The messenger molecules of the endocrine system are called\u00a0endocrine hormones. Other glands of the body, including sweat glands and salivary glands, also secrete substances, but not into the bloodstream. Instead, they secrete them through ducts that carry them to nearby body surfaces. These other glands are not part of the endocrine system. Instead, they are called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_6001\">exocrine glands<\/a>.<\/strong><\/p>\n<p>Endocrine hormones\u00a0act slowly compared with the rapid transmission of electrical messages in the\u00a0nervous system. Endocrine hormones must travel through the bloodstream to the\u00a0cells\u00a0they affect, and this takes time. On the other hand, because endocrine hormones are released into the bloodstream, they travel throughout the body wherever\u00a0blood\u00a0flows. As a result, endocrine hormones may affect many cells and have body-wide effects. The effects of endocrine hormones are also longer lasting than the effects of nervous system messages. Endocrine hormones may cause effects that last for days, weeks, or even months.<\/p>\n<div>\n<h1>Glands of the Endocrine System<\/h1>\n<\/div>\n<p>The major glands of the endocrine system are shown in Figure 9.2.2. The glands in the figure are described briefly in the rest of this section. Refer to the figure as you read about the glands in the following text.<\/p>\n<figure id=\"attachment_3399\" aria-describedby=\"caption-attachment-3399\" style=\"width: 928px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3399 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/1801_The_Endocrine_System-2.jpg\" alt=\"The Endocrine System\" width=\"928\" height=\"831\" \/><figcaption id=\"caption-attachment-3399\" class=\"wp-caption-text\"><em>Figure 9.2.2 The endocrine system. <\/em><\/figcaption><\/figure>\n<div>\n<p>All of the glands labelled in Figure 9.2.2 are part of the endocrine system. Note that the ovary and testis are the only endocrine glands that differ in males and females.<\/p>\n<\/div>\n<h2>Pituitary Gland<\/h2>\n<p>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2938\"><strong>pituitary gland<\/strong><\/a> is located at the\u00a0base\u00a0of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5915\">brain<\/a>. It is controlled by the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2908\">nervous system<\/a>\u00a0via the brain structure called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2937\">hypothalamus<\/a>, to which it is connected by a thin stalk. The pituitary gland consists of two lobes, called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5889\">anterior<\/a> (front) lobe and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3401\">posterior<\/a> (back) lobe. The posterior lobe stores and secretes <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5661\">hormones<\/a> synthesized by the hypothalamus. The anterior lobe synthesizes and secretes its own endocrine hormones, also under the influence of the hypothalamus. One endocrine\u00a0hormone\u00a0secreted by the pituitary gland is growth hormone, which stimulates\u00a0cells\u00a0throughout the body to synthesize\u00a0proteins\u00a0and divide. Most of the other endocrine hormones secreted by the pituitary gland control other\u00a0endocrine glands. Generally, these hormones direct the other glands to secrete either more or less of their hormones, which is why the pituitary gland is often referred to as the \u201cmaster gland\u201d of the endocrine system.<\/p>\n<h2>Remaining Glands of the Endocrine System<\/h2>\n<p>Each of the other glands of the endocrine system is summarized below. Several of these endocrine glands are also discussed in greater detail in other concepts in this chapter.<\/p>\n<ul>\n<li>The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2958\"><strong>thyroid gland<\/strong><\/a>\u00a0is a large gland in the neck. Thyroid hormones (such as thyroxine) increase the rate of metabolism in\u00a0cells\u00a0throughout the body. They control how quickly cells use\u00a0energy\u00a0and make\u00a0proteins.<\/li>\n<li>The four\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3402\">parathyroid glands<\/a><\/strong>\u00a0are located in the neck behind the\u00a0thyroid gland. Parathyroid\u00a0hormone\u00a0helps keep the level of calcium in the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2702\">blood<\/a>\u00a0within a narrow range. It stimulates bone cells to dissolve calcium and release it into the blood.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3403\">pineal gland<\/a><\/strong> is a tiny gland located near the center of the brain. It secretes the hormone <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3404\">melatonin<\/a>, which controls the sleep-wake cycle and several other processes. The production of melatonin is stimulated by darkness and inhibited by light. Cells in the retina of the eye detect light and send signals to a structure in the brain called the suprachiasmatic nucleus (SCN). Nerve fibres carry the signals from the SCN to the pineal gland via the autonomic nervous system.<\/li>\n<li>The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3197\">pancreas<\/a>\u00a0is located near the stomach. Its endocrine hormones include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2590\">insulin<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_6043\">glucagon<\/a>, which work together to control the level of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5451\">glucose<\/a> in the blood. The pancreas also secretes digestive <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5757\">enzymes<\/a>\u00a0into the small intestine.<\/li>\n<li>The two\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5869\">adrenal glands<\/a>\u00a0are located above the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2988\">kidneys<\/a>. Adrenal glands secrete several different endocrine hormones, including the hormone <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5875\">adrenaline<\/a>, which is involved in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_6013\">fight-or-flight response<\/a>. Other endocrine hormones secreted by the adrenal glands have a variety of functions. The hormone <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5881\">aldosterone<\/a>, for example, helps regulate the balance of minerals in the body. The hormone\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5959\">cortisol<\/a><\/strong>\u00a0is also an adrenal gland hormone.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3408\">gonads<\/a><\/strong>\u00a0include the ovaries in females and the testes in males. They secrete sex hormones,\u00a0including\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3409\">testosterone<\/a> (in males) and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5995\">estrogen<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3411\">progesterone<\/a> (in females). These hormones control sexual maturation during puberty and the production of gametes (sperm or egg cells) by the gonads after sexual maturation.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3412\">thymus gland<\/a><\/strong> is located in front of the heart. It is the site where immune system cells, called T cells, mature. T cells are critical to the adaptive immune system, in which the body adapts to specific pathogens.<\/li>\n<\/ul>\n<div>\n<h1>Endocrine System Disorders<\/h1>\n<\/div>\n<p>Diseases of the endocrine system are relatively common. An endocrine system disease usually involves the secretion of too much or not enough of a hormone. When too much hormone is secreted, the condition is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3413\">hypersecretion<\/a>.<\/strong>\u00a0When not enough hormone is secreted, the condition is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3414\">hyposecretion<\/a>.<\/strong><\/p>\n<h2>Hypersecretion and Hyposecretion<\/h2>\n<figure id=\"attachment_3416\" aria-describedby=\"caption-attachment-3416\" style=\"width: 253px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3416\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/MartinVanBurenBates-2.jpeg\" alt=\"Gigamtism\" width=\"253\" height=\"420\" \/><figcaption id=\"caption-attachment-3416\" class=\"wp-caption-text\"><em>Figure 9.2.3 The man on the left, named Martin Van Buren Bates, is depicted in this photo standing next to a man of average size. Bates was a Civil War-era American famed for his incredibly large size. He was at least 7 feet 9 inches tall and weighed close to 500 pounds. He was normal in size at birth, but started to grow very rapidly by about age six years, presumably because of hypersecretion of growth hormone.<\/em><\/figcaption><\/figure>\n<p>Hypersecretion by an endocrine gland is often caused by a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1984\">tumor<\/a>. A tumor of the pituitary gland, for example, can cause hypersecretion of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3415\">growth hormone<\/a>. If this occurs during childhood and goes untreated, it results in very long arms and legs, and an abnormally tall stature by adulthood (see Figure 9.2.3). This condition is commonly known as gigantism.<\/p>\n<div>\n<p><span style=\"text-align: initial; font-size: 1em;\">Hyposecretion by an endocrine gland is often caused by destruction of the hormone-secreting cells of the gland. As a result, not enough of the hormone is secreted. An example of this is type 1 diabetes, in which the body\u2019s own immune system attacks and destroys cells of the pancreas that secrete insulin. This type of diabetes is generally treated with frequent injections of insulin.<\/span><\/p>\n<\/div>\n<h2>Hormone\u00a0Resistance<\/h2>\n<p>In some cases, an endocrine gland secretes a normal amount of hormone, but target cells do not respond normally to it. This may occur because target cells have become resistant to the hormone. An example of this type of endocrine disorder is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3417\">type 2\u00a0diabetes<\/a>. In type 2 diabetes,\u00a0body cells\u00a0do not respond to normal amounts of insulin. As a result, cells do not take up glucose from the blood, leading to high blood glucose levels. Insulin may or may not be needed to treat type 2 diabetes. Instead, it may be treated with lifestyle changes and non-insulin medications.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">9.2 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5985\">endocrine system<\/a> is a system of glands that release chemical messenger molecules called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5661\">hormones<\/a> into the bloodstream. Other glands, called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_6001\">exocrine glands<\/a>, release substances onto nearby body surfaces through ducts. Endocrine hormones travel more slowly than\u00a0nerve impulses, which are the body\u2019s other way of sending messages.\u00a0The effects of endocrine hormones, however, may be much longer lasting.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2938\">pituitary gland<\/a> is the master gland of the endocrine system. Most of the hormones it produces control other endocrine glands. These glands include the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2958\">thyroid gland<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3402\">parathyroid glands<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3403\">pineal gland<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3197\">pancreas<\/a>,\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_5869\">adrenal glands<\/a>, gonads (testes and ovaries), and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3412\">thymus gland<\/a>.<\/li>\n<li>Diseases of the endocrine system are relatively common. An endocrine disease usually involves <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3413\">hypersecretion<\/a> or <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3414\">hyposecretion<\/a> of a hormone. Hypersecretion is frequently caused by a tumor. Hyposecretion is often caused by destruction of hormone-secreting cells by the body\u2019s own immune system.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">9.2 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is the endocrine system? What is its general function?<\/li>\n<li>\n<div id=\"h5p-570\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-570\" class=\"h5p-iframe\" data-content-id=\"570\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"9.2 Review Questions\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>\n<div id=\"h5p-571\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-571\" class=\"h5p-iframe\" data-content-id=\"571\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"9.2 Review Drag and Drop\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Describe the role of the pituitary gland in the endocrine system.<\/li>\n<li>List three endocrine glands other than the pituitary gland. Identify their functions.<\/li>\n<li>Which endocrine gland has an important function in the immune system? What is that function?<\/li>\n<li>Name an endocrine disorder in which too much of a hormone is produced.<\/li>\n<li>What are two reasons people with\u00a0diabetes\u00a0might have signs and symptoms of inadequate insulin?<\/li>\n<li>Besides location, what is the main difference between the anterior lobe of the pituitary and the posterior lobe of the pituitary?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">9.2 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"How do your hormones work? - Emma Bryce\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/-SPRPkLoKp8?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">How do your hormones work? &#8211; Emma Bryce, TED-Ed, 2018.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"What is congenital adrenal hyperplasia (CAH)\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/-gNj5KoWLhE?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">What is congenital adrenal hyperplasia (CAH), Bijniervereniging NVACP, 2014.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-3\" title=\"Cynthia Kenyon: Experiments that hint of longer lives\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/V48M5j-6zdE?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Cynthia Kenyon: Experiments that hint of longer lives, TED, 2011.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 9.2.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Steroidogenesis.svg\" rel=\"cc:attributionURL\">Steroidogenesis.svg<\/a> by David Richfield (<a title=\"User:Slashme\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Slashme\">User:Slashme<\/a>) and <a title=\"User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m <\/a>on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\" rel=\"license\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en) [Derived from previous version by Hoffmeier and Settersr]<\/p>\n<p><strong>Figure 9.2.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:1801_The_Endocrine_System.jpg\" rel=\"cc:attributionURL\">1801_The_Endocrine_System<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/17-1-an-overview-of-the-endocrine-system\">OpenStax College<\/a>\u00a0 on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/p>\n<p><strong>Figure 9.2.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:MartinVanBurenBates.jpeg\" rel=\"cc:attributionURL\">MartinVanBurenBates<\/a> by unknown on Wikimedia Commons is believed to be in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a><i><b>.\u00a0<\/b><\/i><\/p>\n<p>&nbsp;<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text\" data-timestamp=\"1595965908936\" data-highlight-id=\"04a04a28-30d4-4c52-85fa-79509148c52c\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure <\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text\" data-timestamp=\"1595965908936\" data-highlight-id=\"04a04a28-30d4-4c52-85fa-79509148c52c\" data-highlighted=\"true\">17.2<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"98204\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text\" data-timestamp=\"1595965908936\" data-highlight-id=\"04a04a28-30d4-4c52-85fa-79509148c52c\" data-highlighted=\"true\">Endocrine system [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 17.1). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/17-1-an-overview-of-the-endocrine-system<\/span><\/span><\/p>\n<p class=\"hanging-indent\">Bijniervereniging NVACP. (2014, October 11). What is congenital adrenal hyperplasia (CAH)? YouTube. https:\/\/www.youtube.com\/watch?v=-gNj5KoWLhE&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">H\u00e4ggstr\u00f6m M, Richfield D (2014). Diagram of the pathways of human steroidogenesis. <i>WikiJournal of Medicine<\/i>\u00a0<b>1<\/b>\u00a0(1).\u00a0DOI:10.15347\/wjm\/2014.005.\u00a0ISSN\u00a020024436 [Derived from previous version by Hoffmeier and Settersr]<\/p>\n<p class=\"hanging-indent\">TED. (2011, November 17). Cynthia Kenyon: Experiments that hint of longer lives. YouTube. https:\/\/www.youtube.com\/watch?v=V48M5j-6zdE&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2018, June 21). How do your hormones work? &#8211; Emma Bryce. YouTube. https:\/\/www.youtube.com\/watch?v=-SPRPkLoKp8&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4815_5985\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5985\"><div tabindex=\"-1\"><p>The body system which acts as a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. In humans, the major endocrine glands are the thyroid gland and the adrenal glands.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_6001\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_6001\"><div tabindex=\"-1\"><p>Gland such as a sweat gland, salivary gland, or mammary gland that secretes a substance into a duct that carries the secretion to the outside of the body.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_2938\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_2938\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_465\" aria-describedby=\"caption-attachment-465\" style=\"width: 602px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-461\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Blood-Donation-by-USA-Department-of-Defence-Public-Domain.jpg\" alt=\"Blood donation\" width=\"602\" height=\"401\"><figcaption id=\"caption-attachment-465\" class=\"wp-caption-text\"><em>Figure 6.5.1 A phlebotomist draws blood from a blood donor.<\/em><\/figcaption><\/figure>\n<h1>Giving the Gift of Life<\/h1>\n<p>Did you ever donate blood? If you did, then you probably know that your blood type is an important factor in blood transfusions. People vary in the type of blood they inherit, and this determines which type(s) of blood they can safely receive in a transfusion. Do you know your blood type?<\/p>\n<div>\n<h1>What Are Blood Types?<\/h1>\n<\/div>\n<p style=\"text-align: left\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2702\">Blood<\/a> is composed of cells suspended in a liquid called plasma. There are three types of cells in blood: red blood cells, which carry oxygen; white blood cells, which fight infections and other threats; and platelets, which are cell fragments that help blood clot.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2703\">Blood type<\/a><\/strong>\u00a0(or blood group) is a genetic characteristic associated with the presence or absence of certain molecules, called antigens, on the surface of red blood cells. These molecules may help maintain the integrity of the cell membrane, act as receptors, or have other biological functions. A\u00a0<strong>blood group system<\/strong>\u00a0refers to all of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2035\">gene<\/a>(s), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1942\">alleles<\/a>, and possible <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2715\">genotypes<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2477\">phenotypes<\/a>\u00a0that exist for a particular set of blood type antigens. Human blood group systems include the well-known ABO and Rhesus (Rh) systems, as well as at least 33 others that are less well known.<\/p>\n<h2>Antigens and Antibodies<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2704\">Antigens<\/a><\/strong>\u00a0\u2014<strong>\u00a0<\/strong>such as those on the red blood cells \u2014 are molecules that the immune system identifies as either self (produced by your own body) or non-self (not produced by your own body). Blood group antigens may be proteins, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2210\">carbohydrates<\/a>, glycoproteins (proteins attached to chains of sugars), or glycolipids (lipids attached to chains of sugars), depending on the particular blood group system. If antigens are identified as non-self, the immune system responds by forming antibodies that are specific to the non-self antigens. <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2215\">Antibodies<\/a><\/strong> are large, Y-shaped proteins produced by the immune system that recognize and bind to non-self antigens. The analogy of a lock and key is often used to represent how an antibody and antigen fit together, as shown in the illustration below (Figure 6.5.2). When antibodies bind to antigens, it marks them for destruction by other immune system cells. Non-self antigens may enter your body on pathogens (such as bacteria or viruses), on foods, or on red blood cells in a blood transfusion from someone with a different blood type than your own. The last way is virtually impossible nowadays because of effective blood typing and screening protocols.<\/p>\n<figure id=\"attachment_465\" aria-describedby=\"caption-attachment-465\" style=\"width: 492px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-462\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Antibody.svg_.png\" alt=\"Antibody Lock and Key model\" width=\"492\" height=\"694\"><figcaption id=\"caption-attachment-465\" class=\"wp-caption-text\"><em>Figure 6.5.2 Model of antigen and matching antibody. Antibodies will detect antigens based on a match in 3-dimensional shape, as per the lock and key model.<\/em><\/figcaption><\/figure>\n<h2>Genetics of Blood Type<\/h2>\n<p>An individual\u2019s <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2703\">blood type<\/a> depends on which <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1942\">alleles<\/a> for a blood group system were inherited from their parents. Generally, blood type is controlled by alleles for a single <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2035\">gene<\/a>, or for two or more very closely linked genes. Closely linked genes are almost always inherited together, because there is little or no recombination between them. Like other genetic traits, a person\u2019s blood type is generally fixed for life, but there are rare instances in which blood type can change. This could happen, for example, if an individual receives a bone marrow transplant to treat a disease, such as leukemia. If the bone marrow comes from a donor who has a different blood type, the patient\u2019s blood type may eventually convert to the donor\u2019s blood type, because red blood cells are produced in bone marrow.<\/p>\n<div>\n<h1>ABO Blood Group System<\/h1>\n<\/div>\n<p>The\u00a0<strong>ABO blood group system<\/strong> is the best known human blood group system. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2704\">Antigens<\/a> in this system are glycoproteins. These antigens are shown in the list below. There are four common blood types for the ABO system:<\/p>\n<ol>\n<li>Type A, in which only the A antigen is present.<\/li>\n<li>Type B, in which only the B antigen is present.<\/li>\n<li>Type AB, in which both the A and B antigens are present.<\/li>\n<li>Type O, in which neither the A nor the B antigen is present.<\/li>\n<\/ol>\n<h2>Genetics of the ABO System<\/h2>\n<p>The ABO blood group system is controlled by a single<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2035\"> gene<\/a> on <a href=\"https:\/\/en.wikipedia.org\/wiki\/Chromosome_9\">chromosome 9<\/a>. There are three common <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1942\">alleles<\/a> for the gene, often represented by the letters A , B , and O. With three alleles, there are six possible genotypes for ABO blood group. Alleles A and B, however, are both dominant to allele O and codominant to each other. This results in just four possible phenotypes (blood types) for the ABO system. These genotypes and phenotypes are shown in Table 6.5.1.<\/p>\n<p><strong>Table 6.5.1<\/strong><\/p>\n<p><em>ABO Blood Group System: Genotypes and Phenotypes<\/em><\/p>\n<table class=\"grid\" style=\"border-collapse: collapse;width: 49.9637%\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 35.8231%;text-align: center\" colspan=\"2\"><strong>ABO Blood Group System<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 15.0109%\"><strong>Genotype<\/strong><\/td>\n<td style=\"width: 20.8122%\"><strong>Phenotype (Blood Type, or Group)<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 15.0109%\">AA<\/td>\n<td style=\"width: 20.8122%\">A<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 15.0109%\">AO<\/td>\n<td style=\"width: 20.8122%\">A<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 15.0109%\">BB<\/td>\n<td style=\"width: 20.8122%\">B<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 15.0109%\">BO<\/td>\n<td style=\"width: 20.8122%\">B<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 15.0109%\">OO<\/td>\n<td style=\"width: 20.8122%\">O<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 15.0109%\">AB<\/td>\n<td style=\"width: 20.8122%\">AB<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>The diagram below (Figure 6.5.3) shows an example of how ABO blood type is inherited. In this particular example, the father has blood type A (genotype AO) and the mother has blood type B (genotype BO). This mating type can produce children with each of the four possible ABO <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2477\">phenotypes<\/a>, although in any given family, not all phenotypes may be present in the children.<\/p>\n<figure id=\"attachment_465\" aria-describedby=\"caption-attachment-465\" style=\"width: 590px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-463\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/ABO_system_codominance.svg_.png\" alt=\"Example of the ABO system codominance\" width=\"590\" height=\"588\"><figcaption id=\"caption-attachment-465\" class=\"wp-caption-text\"><em>Figure 6.5.3 Example of ABO blood group inheritance.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Medical Significance of ABO Blood Type<\/span><\/p>\n<\/div>\n<p>The ABO system is the most important blood group system in blood transfusions. If red blood cells containing a particular ABO antigen are transfused into a person who lacks that antigen, the person\u2019s immune system will recognize the antigen on the red blood cells as non-self. Antibodies specific to that antigen will attack the red blood cells, causing them to agglutinate (or clump) and break apart. If a unit of incompatible blood were to be accidentally transfused into a patient, a severe reaction (called <a href=\"https:\/\/medlineplus.gov\/ency\/article\/001303.htm\">acute hemolytic transfusion reaction<\/a>) is likely to occur, in which many red blood cells are destroyed. This may result in kidney failure, shock, and even death. Fortunately, such medical accidents virtually never occur today.<\/p>\n<p>These antibodies are often spontaneously produced in the first years of life, after exposure to common microorganisms in the environment that have antigens similar to blood antigens. Specifically, a person with type A blood will produce anti-B antibodies, while a person with type B blood will produce anti-A antibodies. A person with type AB blood does not produce either antibody, while a person with type O blood produces both anti-A and anti-B antibodies. Once the antibodies have been produced, they circulate in the plasma. The relationship between ABO red blood cell antigens and plasma antibodies is shown in Figure 6.5.4.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_465\" aria-describedby=\"caption-attachment-465\" style=\"width: 1016px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-412\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/ABO_blood_type.svg_.png\" alt=\"Image shows a table of each blood type, which antigens and antibodies are present, and acceptable blood donor types.\" width=\"1016\" height=\"653\"><figcaption id=\"caption-attachment-465\" class=\"wp-caption-text\"><em>Figure 6.5.4 The relationship between ABO red blood cell antigens and plasma antibodies.<\/em><\/figcaption><\/figure>\n<div>\n<p><em>The antibodies that circulate in the plasma are for different antigens than those on red blood cells, which are recognized as self antigens.<\/em><\/p>\n<\/div>\n<figure id=\"attachment_465\" aria-describedby=\"caption-attachment-465\" style=\"width: 273px\" class=\"wp-caption alignright\"><img class=\"wp-image-464 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blood-Donor-and-recipient-ABO-e1588625024858.png\" alt=\"Blood donors and recipients\" width=\"273\" height=\"272\"><figcaption id=\"caption-attachment-465\" class=\"wp-caption-text\"><em>Figure 6.5.5 You can always donate blood to someone who has the same blood type as yours, but you may or may not be able to donate to people who have other blood types, as indicated in this diagram.<\/em><\/figcaption><\/figure>\n<p>Which blood types are compatible and which are not? Type O blood contains both anti-A and anti-B antibodies, so people with type O blood can only receive type O blood. However, they can\u00a0<em>donate<\/em>\u00a0blood to people of\u00a0<em>any<\/em>\u00a0ABO blood type, which is why individuals with type O blood are called\u00a0<strong>universal donors.<\/strong>\u00a0Type AB blood contains neither anti-A nor anti-B antibodies, so people with type AB blood can receive blood from people of any ABO blood type. That\u2019s why individuals with type AB blood are called\u00a0<strong>universal recipients.<\/strong>\u00a0They can donate blood, however,\u00a0<em>only<\/em> to people who also have type AB blood. These and other relationships between blood types of donors and recipients are summarized in the simple diagram to the right.<\/p>\n<h3>Geographic Distribution of ABO Blood Groups<\/h3>\n<p>The frequencies of blood groups for the ABO system vary around the world. You can see how the A and B alleles and the blood group O are distributed geographically on the maps in Figure 6.5.6.<\/p>\n<ul>\n<li>Worldwide, B is the rarest ABO allele, so type B blood is the least common ABO blood type. Only about 16 per cent of all people have the B allele. Its highest frequency is in Asia. Its lowest frequency is among the indigenous people of Australia and the Americas.<\/li>\n<li>The A allele is somewhat more common around the world than the B allele, so type A blood is also more common than type B blood. The highest frequencies of the A allele are in Australian Aborigines, the Lapps (Sami) of Northern Scandinavia, and Blackfoot Native Americans in North America. The allele is nearly absent among Native Americans in Central and South America.<\/li>\n<li>The O allele is the most common ABO allele around the world, and type O blood is the most common ABO blood type. Almost two-thirds of people have at least one copy of the O allele. It is especially common in Native Americans in Central and South America, where it reaches frequencies close to 100 per cent. It also has relatively high frequencies in Australian Aborigines and Western Europeans. Its frequencies are lowest in Eastern Europe and Central Asia.<\/li>\n<\/ul>\n<div>\n<div id=\"h5p-89\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-89\" class=\"h5p-iframe\" data-content-id=\"89\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Global Distribution or Blood Groups\"><\/iframe><\/div>\n<\/div>\n<p><em>Figure 6.5.6 Maps of populations that have the A, B and O alleles.\u00a0<\/em><\/p>\n<\/div>\n<h2>Evolution of the ABO Blood Group System<\/h2>\n<p>The geographic distribution of ABO blood type alleles provides indirect evidence for the evolutionary history of these alleles. Evolutionary biologists hypothesize that the allele for blood type A evolved first, followed by the allele for blood type O, and then by the allele for blood type B. This chronology accounts for the percentages of people worldwide with each blood group, and is also consistent with known patterns of early population movements.<\/p>\n<p>The evolutionary forces of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2686\">founder effect<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2710\">genetic drift<\/a> have no doubt played a significant role in the current distribution of ABO blood types worldwide. Geographic variation in ABO blood groups is also likely to be influenced by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2633\">natural selection<\/a>, because different blood types are thought to vary in their susceptibility to certain diseases. For example:<\/p>\n<ul>\n<li>People with type O blood may be more susceptible to cholera and plague. They are also more likely to develop gastrointestinal ulcers.<\/li>\n<li>People with type A blood may be more susceptible to smallpox and more likely to develop certain cancers.<\/li>\n<li>People with types A, B, and AB blood appear to be less likely to form blood clots that can cause strokes. However, early in our history, the ability of blood to form clots \u2014 which appears greater in people with type O blood \u2014 may have been a survival advantage.<\/li>\n<li>Perhaps the greatest natural selective force associated with ABO blood types is malaria. There is considerable evidence to suggest that people with type O blood are somewhat resistant to malaria, giving them a selective advantage where malaria is endemic.<\/li>\n<\/ul>\n<div>\n<h1>Rhesus Blood Group System<\/h1>\n<\/div>\n<p>Another well-known blood group system is the\u00a0<strong>Rhesus (Rh) blood group system<\/strong>. The Rhesus system has dozens of different antigens, but only five main antigens (called\u00a0D, C, c, E, and e). The major Rhesus antigen is the D antigen. People with the D antigen are called Rh positive (Rh+), and people who lack the D antigen are called Rh negative (Rh-). Rhesus antigens are thought to play a role in transporting ions across cell membranes by acting as channel proteins.<\/p>\n<p>The Rhesus blood group system is controlled by two linked genes on <a href=\"https:\/\/en.wikipedia.org\/wiki\/Chromosome_1\">chromosome 1<\/a>. One gene, called RHD, produces a single antigen, antigen D. The other gene, called RHCE, produces the other four relatively common Rhesus antigens (C, c, E, and e), depending on which alleles for this gene are inherited.<\/p>\n<h2>Rhesus Blood Group and Transfusions<\/h2>\n<p>After the ABO system, the Rhesus system is the second most important blood group system in blood transfusions. The D antigen is the one most likely to provoke an immune response in people who lack the antigen. People who have the D antigen (Rh+) can be safely transfused with either Rh+ or Rh- blood, whereas people who lack the D antigen (Rh-) can be safely transfused only with Rh- blood.<\/p>\n<p>Unlike anti-A and anti-B antibodies to ABO antigens, anti-D antibodies for the Rhesus system are not usually produced by sensitization to environmental substances.\u00a0People who lack the D antigen (Rh-), however, may produce anti-D antibodies if exposed to Rh+ blood. This may happen accidentally in a blood transfusion, although this is extremely unlikely today. It may also happen during pregnancy with an Rh+ fetus if some of the fetal blood cells pass into the mother\u2019s blood circulation.<\/p>\n<h2>Hemolytic Disease of the Newborn<\/h2>\n<p>If a woman who is Rh- is carrying an Rh+ fetus, the fetus may be at risk. This is especially likely if the mother has formed anti-D antibodies during a prior pregnancy because of a mixing of maternal and fetal blood during childbirth. Unlike antibodies against ABO antigens, antibodies against the Rhesus D antigen can cross the placenta and enter the blood of the fetus. This may cause\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK2266\/\"><strong>hemolytic disease of the newborn (HDN)<\/strong><\/a>, also called erythroblastosis fetalis, an illness in which fetal red blood cells are destroyed by maternal antibodies, causing <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2061\">anemia<\/a>. This illness may range from mild to severe. If it is severe, it may cause brain damage and is sometimes fatal for the fetus or newborn. Fortunately, HDN can be prevented by preventing the formation of anti-D antibodies in the Rh- mother. This is achieved\u00a0by injecting the\u00a0mother\u00a0with\u00a0a medication called Rho(D) immune globulin.<\/p>\n<h2>Geographic Distribution of Rhesus Blood Types<\/h2>\n<p>The majority of people worldwide are Rh+, but there is regional variation in this blood group system, as there is with the ABO system. The aboriginal inhabitants of the Americas and Australia originally had very close to 100 per cent Rh+ blood. The frequency of the Rh+ blood type is also very high in African populations, at about 97 to 99 per cent. In East Asia, the frequency of Rh+ is slightly lower, at about 93 to 99 per cent. Europeans have the lowest frequency of the Rh+ blood type at about 83 to 85 per cent.<\/p>\n<p>What explains the population variation in Rhesus blood types? Prior to the advent of modern medicine, Rh+ positive children conceived by Rh- women were at risk of fetal or newborn death or impairment from HDN. This\u00a0was\u00a0an enigma, because presumably, natural selection would work to\u00a0<em>remove<\/em>\u00a0the rarer phenotype (Rh-) from populations. However, the frequency of this phenotype is relatively high in many populations.<\/p>\n<p>Recent studies have found evidence that natural selection may actually favor heterozygotes for the Rhesus D antigen. The selective agent in this case is thought to be\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2718\">toxoplasmosis<\/a>,<\/strong>\u00a0a parasitic disease caused by the protozoan\u00a0<em>Toxoplasma gondii,<\/em> which is very common worldwide. You can see a life cycle diagram of the parasite in Figure 6.5.7. Infection by this parasite often causes no symptoms at all, or it may cause flu-like symptoms for a few days or weeks. Exposure to the parasite has been linked, however, to increased risk of mental disorders (such as schizophrenia), neurological disorders (such as Alzheimer\u2019s), and other neurological problems, including delayed reaction times. One study found that people who tested positive for antibodies to the parasite were more than twice as likely to be involved in traffic accidents.<\/p>\n<figure id=\"attachment_465\" aria-describedby=\"caption-attachment-465\" style=\"width: 627px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-465\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Toxoplasma_gondii_Life_cycle_PHIL_3421_lores.jpg\" alt=\"Toxoplasmosis Life Cycle\" width=\"627\" height=\"822\"><figcaption id=\"caption-attachment-465\" class=\"wp-caption-text\"><em>Figure 6.5.7 Toxoplasmosis (toxoplasma gondii): Infective and diagnostic stages.\u00a0<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"text-align: initial;font-size: 1em\">People who are heterozygous for the D antigen appear less likely to develop the negative neurological and mental effects of <em style=\"text-align: initial;font-size: 1em\">Toxoplasma gondii <\/em>infection<\/span><span style=\"text-align: initial;font-size: 1em\">. This could help explain why both phenotypes (Rh+ and Rh-) are maintained in most populations. There are also striking geographic differences in the prevalence of <a href=\"https:\/\/www.cdc.gov\/parasites\/toxoplasmosis\/gen_info\/faqs.html\">toxoplasmosis<\/a> worldwide, ranging from zero to 95 per cent in different regions. This could explain geographic variation in the D antigen worldwide, because its strength as a selective agent would vary with its prevalence.<\/span><\/p>\n<\/div>\n<div>\n<h1>Feature: Myth vs. Reality<\/h1>\n<table class=\"grid\" style=\"border-collapse: collapse;width: 100%;height: 140px\" border=\"0\">\n<tbody>\n<tr style=\"height: 98px\">\n<td style=\"width: 33.1116%;height: 98px\">\n<h2><span style=\"color: #ff0000\">Myth<\/span><\/h2>\n<\/td>\n<td style=\"width: 66.8884%;height: 98px\">\n<h2><span style=\"color: #339966\">Reality<\/span><\/h2>\n<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"width: 33.1116%;height: 14px\"><em><span style=\"font-size: 16px\">\"Your nutritional needs can be determined by your ABO blood type. Knowing your blood type allows you to choose the appropriate foods that will help you lose weight, increase your energy, and live a longer, healthier life.\"<\/span><\/em><\/td>\n<td style=\"width: 66.8884%;height: 14px\"><strong><span style=\"font-size: 16px\">This idea was proposed in 1996 in a\u00a0<\/span><em style=\"font-size: 16px\">New York Times<\/em><span style=\"font-size: 16px\">\u00a0bestseller\u00a0<\/span><em style=\"font-size: 16px\">Eat Right for Your Type<\/em><span style=\"font-size: 16px\">, by Peter D\u2019Adamo, a naturopath. Naturopathy is a method of treating disorders that involves the use of herbs, sunlight, fresh air, and other natural substances. Some medical doctors consider naturopathy a pseudoscience. A major scientific review of the blood type diet could find no evidence to support it. In one study, adults eating the diet designed for blood type A showed improved health \u2014 but this occurred in everyone, regardless of their blood type. Because the blood type diet is based solely on blood type, it fails to account for other factors that might require dietary adjustments or restrictions. For example, people with diabetes \u2014 but different blood types \u2014 would follow different diets, and one or both of the diets might conflict with standard diabetes dietary recommendations and be dangerous.<\/span><\/strong><\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"width: 33.1116%;height: 14px\"><em><span style=\"font-size: 16px\">\"ABO blood type is associated with certain personality traits. People with blood type A, for example, are patient and responsible, but may also be stubborn and tense, whereas people with blood type B are energetic and creative, but may also be irresponsible and unforgiving. In selecting a spouse, both your own and your potential mate\u2019s blood type should be taken into account to ensure compatibility of your personalities.\"<\/span><\/em><\/td>\n<td style=\"width: 66.8884%;height: 14px\"><strong><span style=\"font-size: 16px\">The belief that blood type is correlated with personality is widely held in Japan and other East Asian countries. The idea was originally introduced in the 1920s in a study commissioned by the Japanese government, but it was later shown to have no scientific support. The idea was revived in the 1970s by a Japanese broadcaster, who wrote popular books about it. There is no scientific basis for the idea, and it is generally dismissed as pseudoscience by the scientific community. Nonetheless, it remains popular in East Asian countries, just as astrology is popular in many other countries.<\/span><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.5 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Blood type (or blood group) is a genetic characteristic associated with the presence or absence of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2704\">antigens<\/a> on the surface of red blood cells. A blood group system refers to all of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2035\">gene<\/a>(s), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1942\">alleles<\/a>, and possible <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2715\">genotypes<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2477\">phenotype<\/a>s that exist for a particular set of blood type antigens.<\/li>\n<li>Antigens are molecules that the immune system identifies as either self or non-self. If antigens are identified as non-self, the immune system responds by forming antibodies that are specific to the non-self antigens, leading to the destruction of cells bearing the antigens.<\/li>\n<li>The ABO blood group system is a system of red blood cell antigens controlled by a single gene with three common alleles on chromosome 9. There are four possible ABO blood types: A, B, AB, and O. The ABO system is the most important blood group system in blood transfusions. People with type O blood are universal donors, and people with type AB blood are universal recipients.<\/li>\n<li>The frequencies of ABO blood type alleles and blood groups vary around the world. The allele for the B antigen is least common, and blood type O is the most common. The evolutionary forces of founder effect, genetic drift, and natural selection are responsible for the geographic distribution of ABO alleles and blood types.\u00a0People with type O blood, for example, may be somewhat resistant to malaria, possibly giving them a selective advantage where malaria is endemic.<\/li>\n<li>The Rhesus blood group system is a system of red blood cell antigens controlled by two genes with many alleles on chromosome 1. There are five common Rhesus antigens, of which antigen D is most significant. Individuals who have antigen D are called Rh+, and individuals who lack antigen D are called Rh-. Rh- mothers of Rh+ fetuses may produce antibodies against the D antigen in the fetal blood, causing hemolytic disease of the newborn (HDN).<\/li>\n<li>The majority of people worldwide are Rh+, but there is regional variation in this blood group system. This variation may be explained by natural selection that favors heterozygotes for the D antigen, because this genotype seems to be protected against some of the neurological\u00a0consequences\u00a0of the common parasitic infection toxoplasmosis.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.5 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Define blood type and blood group system.<\/li>\n<li>Explain the relationship between antigens and antibodies.<\/li>\n<li>Identify the alleles, genotypes, and phenotypes in the ABO blood group system.<\/li>\n<li>Discuss the medical significance of the ABO blood group system.<\/li>\n<li>Compare the relative worldwide frequencies of the three ABO alleles.<\/li>\n<li>Give examples of how different ABO blood types vary in their susceptibility to diseases.<\/li>\n<li>Describe the Rhesus blood group system.<\/li>\n<li>Relate Rhesus blood groups to blood transfusions.<\/li>\n<li>What causes hemolytic disease of the newborn?<\/li>\n<li>Describe\u00a0how toxoplasmosis may explain the persistence of the Rh- blood type in human populations.<\/li>\n<li>A woman is blood type O and Rh-, and her husband is blood type AB and Rh+. Answer the following questions about this couple and their offspring.\n<ol type=\"a\">\n<li>What are the possible genotypes of their offspring in terms of ABO blood group?<\/li>\n<li>What are the possible phenotypes of their offspring in terms of ABO blood group?<\/li>\n<li>Can the woman donate blood to her husband? Explain your answer.<\/li>\n<li>Can the man donate blood to his wife? Explain your answer.<\/li>\n<\/ol>\n<\/li>\n<li>Type O blood is characterized by the presence of O antigens \u2014 explain why this statement is false.<\/li>\n<li>Explain why newborn hemolytic disease may be more likely to occur in a second pregnancy than in a first.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.5 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=xfZhb6lmxjk<\/p>\n<p style=\"text-align: center\">Why do blood types matter? - Natalie S. Hodge, TED-Ed, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=qcZKbjYyOfE<\/p>\n<p class=\"title style-scope ytd-video-primary-info-renderer\" style=\"text-align: center\">How do blood transfusions work? - Bill Schutt, TED-Ed, 2020.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributes<\/h2>\n<p><strong>Figure 6.5.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.defense.gov\/Explore\/News\/Article\/Article\/604005\/\" rel=\"cc:attributionURL\">Following the Blood Donation Trail<\/a> by <i>EJ Hersom\/<\/i> USA Department of Defense is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a>. [<a href=\"https:\/\/www.dimoc.mil\/resources\/limitations\/\">Disclaimer<\/a>: The appearance of U.S. Department of Defense (DoD) visual information does not imply or constitute DoD endorsement.]<\/p>\n<p><strong>Figure 6.5.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Antibody.svg\" rel=\"cc:attributionURL\">Antibody<\/a> by <a title=\"User:Fvasconcellos\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Fvasconcellos\">Fvasconcellos<\/a>\u00a0 on Wikimedia Commons is released into\u00a0the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 6.5.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:ABO_system_codominance.svg\">ABO system codominance.svg<\/a>, adapted by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:YassineMrabet\">YassineMrabet<\/a> (original \"Codominant\" image from <a href=\"https:\/\/ghr.nlm.nih.gov\/primer\/inheritance\/riskassessment\">US National Library of Medicine)<\/a>\u00a0<i>on Wikimedia Commons is in the\u00a0<\/i><a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain)<i>.<\/i><\/p>\n<p><strong>Figure 6.5.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:ABO_blood_type.svg\" rel=\"cc:attributionURL\">ABO_blood_type.svg<\/a> by <a class=\"new\" title=\"User:InvictaHOG (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:InvictaHOG&amp;action=edit&amp;redlink=1\">InvictaHOG<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain)<i>.<\/i><\/p>\n<p><strong>Figure 6.5.5<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/8.6\/\" rel=\"cc:attributionURL\">Blood Donor and recipient ABO<\/a>\u00a0by <a href=\"https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/8.6\/\">CK-12 Foundation<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\">CC BY-NC 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.<\/p>\n<div><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em\">Licensed under\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/div>\n<p><strong>Figure 6.5.6<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/File:Map_of_blood_group_a.gif\">Map of Blood Group A<\/a> by <a class=\"extiw\" title=\"en:User:Muntuwandi\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Muntuwandi\">Muntuwandi<\/a>\u00a0at\u00a0<a class=\"external text\" href=\"https:\/\/en.wikipedia.org\/\">en.wikipedia<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/) license.<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Map_of_blood_group_b.gif\">Map of Blood Group B<\/a> by <a class=\"extiw\" title=\"en:User:Muntuwandi\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Muntuwandi\">Muntuwandi<\/a>\u00a0at\u00a0<a class=\"external text\" href=\"https:\/\/en.wikipedia.org\/\">en.wikipedia<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/) license.<\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/File:Map_of_blood_group_o.gif\">Map of Blood Group O<\/a> by anthro palomar at\u00a0<a class=\"external text\" href=\"https:\/\/en.wikipedia.org\/\">en.wikipedia<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/) license.<\/li>\n<\/ul>\n<p><strong>Figure 6.5.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Toxoplasma_gondii_Life_cycle_PHIL_3421_lores.jpg\" rel=\"cc:attributionURL\">Toxoplasma_gondii_Life_cycle_PHIL_3421_lores<\/a> by Alexander J. da Silva, PhD\/Melanie Moser, <a class=\"extiw\" title=\"w:Centers for Disease Control and Prevention\" href=\"https:\/\/en.wikipedia.org\/wiki\/Centers_for_Disease_Control_and_Prevention\">Centers for Disease Control and Prevention<\/a>'s\u00a0<a class=\"external text\" href=\"https:\/\/phil.cdc.gov\/\" rel=\"nofollow\">Public Health Image Library<\/a> (PHIL<b><a class=\"external text\" href=\"https:\/\/phil.cdc.gov\/details.aspx?pid=3421\" rel=\"nofollow\">#3421<\/a><\/b>) on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Table 6.5.1\u00a0<\/strong><\/p>\n<p><em>ABO Blood Group System: Genotypes and Phenotypes<\/em> was created by Christine Miller.<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 1.424em;font-weight: bold;text-align: initial\">References<\/span><\/p>\n<p class=\"hanging-indent\">Dean, L. (2005). Chapter 4 Hemolytic disease of the newborn. In <em>Blood Groups and Red Cell Antigens<\/em> [Internet]. National Center for Biotechnology Information (US). https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK2266\/<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Toxoplasmosis [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/toxoplasmosis\/symptoms-causes\/syc-20356249<\/p>\n<p class=\"hanging-indent\">MedlinePlus. (2019, January 29). Hemolytic transfusion reaction [online article]. U.S. National Library of Medicine. https:\/\/en.wikipedia.org\/w\/index.php?title=Chromosome_9&amp;oldid=946440619<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2015, June 29). Why do blood types matter? - Natalie S. Hodge. YouTube. https:\/\/www.youtube.com\/watch?v=xfZhb6lmxjk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2020, February 18). How do blood transfusions work? - Bill Schutt. YouTube. https:\/\/www.youtube.com\/watch?v=qcZKbjYyOfE&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, May 10). Chromosome 1. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Chromosome_1&amp;oldid=955942444<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, March 20). Chromosome 9. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Chromosome_9&amp;oldid=946440619<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5915\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5915\"><div tabindex=\"-1\"><p>The central nervous system organ inside the skull that is the control center of the nervous system.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_2908\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_2908\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 1024px\" class=\"wp-caption alignnone\"><img class=\"wp-image-250 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Ribosomal-Art.jpg\" alt=\"Image shows a large 3D work of art displayed at the Cold Spring Harbor Laboratory. It is a representation of ribosomes attached to a ribbon of metal meant to represent a strand of messenger RNA.\" width=\"1024\" height=\"768\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.1 \"Waltz of the Polypeptides\" sculpture by New York City-based artist Mara G. Haseltine, on display at Cold Spring Harbor Laboratory, NY.\u00a0 This artwork features multiple ribosomes creating polypeptides according to the directions on a piece of messenger RNA.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Ribosome\u00a0Review<\/h1>\n<\/div>\n<p>The 25-metre long sculpture shown in Figure 4.6.1 is a recognition of the beauty of one of the metabolic functions that takes place in the cells in your body.\u00a0 This artwork brings to life an important structure in living cells: the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2074\">ribosome<\/a><\/strong>, the\u00a0cell structure\u00a0where\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2422\">proteins<\/a>\u00a0are synthesized. The slender silver strand is the messenger <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_519\">RNA<\/a>(mRNA)\u00a0bringing the code for a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2422\">protein<\/a> out into the cytoplasm.\u00a0 The purple and green structures are ribosomal subunits (which together form a single <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2074\">ribosome<\/a>), which can \"read\" the code on the mRNA and direct the bonding of the correct sequence of amino acids to create a protein.\u00a0\u00a0All living\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2223\">cells<\/a>\u00a0\u2014 whether they are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1572\">prokaryotic<\/a> or <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1573\">eukaryotic<\/a> \u2014 contain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2074\">ribosomes<\/a>, but only eukaryotic cells also contain a\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2402\">nucleus<\/a>\u00a0and several other types of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2083\">organelles<\/a>.<\/p>\n<div>\n<h1>What Are Organelles?<\/h1>\n<\/div>\n<p>An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2083\">organelle<\/a><\/strong>\u00a0is a structure within the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1963\">cytoplasm<\/a> of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1573\">eukaryotic<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2223\">cell<\/a> that is enclosed within a membrane and performs a specific job. Organelles are involved in many vital cell functions. Organelles in animal cells include the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2402\">nucleus<\/a>,\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2383\">mitochondria<\/a>,\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2335\">endoplasmic reticulum<\/a>,\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1991\">Golgi apparatus<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2437\">vesicles<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2430\">vacuoles<\/a>. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2074\">Ribosomes<\/a>\u00a0are not enclosed within a membrane, but they are still commonly referred to as organelles in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1573\">eukaryotic<\/a> cells.<\/p>\n<div>\n<h1>The Nucleus<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2402\">nucleus<\/a><\/strong> is the largest organelle in a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1573\">eukaryotic<\/a> cell, and it's considered the cell\u2019s control center. It contains most of the cell\u2019s <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_277\">DNA<\/a>(which makes up chromosomes), and it is encoded with the genetic instructions for making <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2422\">proteins<\/a>. The function of the nucleus is to regulate gene expression, including controlling which proteins the cell makes. In addition to DNA, the nucleus contains a thick liquid called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2097\">nucleoplasm<\/a><\/strong>, which\u00a0is similar in\u00a0composition\u00a0to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2319\">cytosol<\/a> found in the cytoplasm outside the nucleus.\u00a0Most eukaryotic cells contain just a single nucleus, but some types of cells (such as red\u00a0blood\u00a0cells) contain no nucleus and a few other types of cells (such as muscle cells) contain multiple nuclei.<\/p>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 459px\" class=\"wp-caption alignright\"><img class=\" wp-image-251\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nucleus-1.png\" alt=\"This closeup of a cell nucleus shows that it is surrounded by a structure called the nuclear envelope, which contains tiny perforations, or pores. The nucleus also contains a dense center called the nucleolus.\" width=\"459\" height=\"425\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.2 This closeup of a cell nucleus shows that it is surrounded by a structure called the nuclear envelope, which contains tiny perforations, or pores. The nucleus also contains a dense center called the nucleolus.<\/em><\/figcaption><\/figure>\n<p>As you can see in the model pictured in Figure 4.6.2, the membrane enclosing the nucleus is called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2386\">nuclear envelope<\/a><\/strong>. This is actually a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm. Tiny holes called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2391\">nuclear pores<\/a><\/strong>\u00a0allow large molecules to pass through the nuclear envelope, with the help of special proteins. Large proteins and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_519\">RNA<\/a>\u00a0molecules must be able to pass through the nuclear envelope so proteins can be synthesized in the cytoplasm and the genetic material can be maintained inside the nucleus. The nucleolus shown in the model\u00a0below\u00a0is mainly involved in the assembly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2074\">ribosomes<\/a>. After being produced in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2397\">nucleolus<\/a>, ribosomes are exported to the cytoplasm, where they are involved in the synthesis of proteins.<\/p>\n<div>\n<h1>Mitochondria<\/h1>\n<\/div>\n<p>The\u00a0<strong>mitochondrion<\/strong>\u00a0(plural, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2383\">mitochondria<\/a>) is an organelle that makes\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2340\">energy<\/a>\u00a0available to the cell. This is why\u00a0mitochondria\u00a0are sometimes referred to as the \"power plants of the cell.\" They use energy from\u00a0organic compounds\u00a0(such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1945\">glucose<\/a>) to make molecules of\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2072\">ATP<\/a> (adenosine triphosphate)<\/strong>, an energy-carrying molecule that is used almost universally inside cells for\u00a0energy.<\/p>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 459px\" class=\"wp-caption alignleft\"><img class=\" wp-image-252\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Mitochondrion_structure.svg_.png\" alt=\"Image shows a diagram of a mitochondrion. Labelled are the inner and outer membranes, the intermembrane space, the matrix, DNA and ribosomes.\" width=\"459\" height=\"265\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.3 Mitochondria contain their own DNA and ribosomes!<\/em><\/figcaption><\/figure>\n<p>Mitochondria (as in the Figure 4.6.3 diagram) have a complex structure including an inner and out membrane.\u00a0 In addition, mitochondria have their own DNA, ribosomes, and a version of cytoplasm, called matrix.\u00a0 Does this sound similar to the requirements to be considered a cell?\u00a0 That's because they are!<\/p>\n<p>Scientists think that mitochondria were once free-living organisms because they contain their own\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_277\">DNA<\/a>. They theorize that ancient\u00a0prokaryotes\u00a0infected (or were engulfed by) larger <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1572\">prokaryotic<\/a> cells, and the two organisms evolved a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2428\">symbiotic<\/a> relationship that benefited both of them. The larger cells provided the smaller prokaryotes with a place to live. In return, the larger cells got extra\u00a0energy\u00a0from the smaller prokaryotes. Eventually, the smaller prokaryotes became permanent guests of the larger cells, as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2083\">organelles<\/a>\u00a0inside them. This theory is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1986\">endosymbiotic theory<\/a>,<\/strong> and it is widely accepted by biologists today. (See the video <span style=\"text-align: initial;font-size: 1em\">in <a href=\"http:\/\/humanbiology.pressbooks.tru.ca\/chapter\/4-3-variation-in-cells\/\">section 4.3<\/a> to learn all about endosymbiotic theory.)<\/span><\/p>\n<div>\n<h1>Endoplasmic Reticulum<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2335\">endoplasmic reticulum<\/a><\/strong><strong>\u00a0(ER)<\/strong> is an organelle that helps make and transport <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2422\">proteins<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2205\">lipids<\/a>. There are two types of endoplasmic reticulum: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2145\">rough endoplasmic reticulum<\/a> (rER) and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2101\">smooth endoplasmic reticulum<\/a> (sER). Both types are shown in Figure 4.6.4.<\/p>\n<ul>\n<li>rER looks rough because it is studded with ribosomes. It provides a framework for the ribosomes, which make proteins. Bits of its membrane pinch off to form tiny sacs called vesicles, which carry proteins away from the ER.<\/li>\n<li>sER looks smooth because it does not have ribosomes. sER makes\u00a0lipids, stores substances, and plays other roles.<\/li>\n<\/ul>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 726px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-253\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Endomembrane_system_diagram_en.svg_.png\" alt=\"Image shows a diagram of the organelles included in the endomembrane system, inclduing: nuclear envelope, rough ER, smooth ER, golgi body, cell membrane, and vesicles.\" width=\"726\" height=\"577\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.4 The rough and smooth ER are part of a larger group of organelles termed \"the endomembrane system\". All of the organelles in this system are composed of plasma membrane.<\/em><\/figcaption><\/figure>\n<div>\n<p>The Figure 4.6.4 drawing includes the nucleus, rER, sER, and Golgi apparatus. From the drawing, you can see how all these organelles work together to make and transport proteins.<\/p>\n<\/div>\n<div>\n<h1>Golgi Apparatus<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1991\">Golgi apparatus<\/a><\/strong> (shown in the Figure 4.6.4 diagram) is a large organelle that processes proteins and prepares them for use both inside and outside the cell. You can see the Golgi apparatus in the figure above. The Golgi apparatus is something like a post office. It receives items (proteins from the ER), then packages and labels them before sending them on to their destinations (to different parts of the cell or to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2169\">cell membrane<\/a> for transport out of the cell). The Golgi apparatus is also involved in the transport of lipids around the cell.<\/p>\n<div>\n<h1>Vesicles and Vacuoles<\/h1>\n<\/div>\n<p>Both\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2437\">vesicles<\/a><\/strong>\u00a0and\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2430\">vacuoles<\/a>\u00a0<\/strong>are sac-like organelles made of phospholipid bilayer that store and transport materials in the cell. Vesicles are much smaller than vacuoles and have a variety of functions. The vesicles that pinch off from the membranes of the ER and Golgi apparatus store and transport <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2422\">protein<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2205\">lipid<\/a> molecules. You can see an example of this type of transport vesicle in the Figure 4.6.4. Some vesicles are used as chambers for biochemical reactions.<\/p>\n<p>There are some vesicles which are specialized to carry out specific functions.\u00a0 L<span style=\"font-size: 1em\">ysosomes, which use\u00a0enzymes\u00a0to break down foreign matter and dead cells, have a double membrane to make sure their contents don't leak into the rest of the cell.\u00a0 Peroxisomes are another type of specialized vesicle with the main function of breaking down fatty acids and some toxins.\u00a0<\/span><\/p>\n<div>\n<h1>Centrioles<\/h1>\n<\/div>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 442px\" class=\"wp-caption alignright\"><img class=\"wp-image-254 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Centrioles-1.png\" alt=\"Image shows a diagram of a centriole, made up of microtubules. There are nine bundles of microtubules arranged in a circle to form the tube-shaped centriole.\" width=\"442\" height=\"255\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.5 Centrioles are tiny cylinders near the nucleus, enlarged here to show their tubular structure.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2093\">Centrioles<\/a><\/strong>\u00a0are organelles involved in\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2186\">cell division<\/a>. The function of centrioles is to help organize the\u00a0<span style=\"font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2166\">chromosomes<\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0before cell division occurs so that each daughter cell has the correct number of chromosomes after the cell divides. Centrioles are found only in animal cells, and are located near the nucleus. Each centriole is made mainly of a\u00a0<\/span>protein<span style=\"text-align: initial;font-size: 1em\">\u00a0named tubulin. The centriole is cylindrical in shape and consists of many microtubules, as shown in the model pictured\u00a0<\/span>in Figure 4.6.5<span style=\"text-align: initial;font-size: 1em\">.<\/span><\/p>\n<div>\n<figure id=\"attachment_255\" aria-describedby=\"caption-attachment-255\" style=\"width: 333px\" class=\"wp-caption alignleft\"><img class=\" wp-image-255\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Ribosome_shape.png\" alt=\"Image shows a diagram of a ribosome. It is made up of two sub-units, a smaller sub-unit shown in blue and a larger sub-unit shown in red.\" width=\"333\" height=\"314\"><figcaption id=\"caption-attachment-255\" class=\"wp-caption-text\"><em>Figure 4.6.6 Ribosomes are made up of two subunits, each consisting of protein and rRNA.<\/em><\/figcaption><\/figure>\n<h1>Ribosomes<\/h1>\n<\/div>\n<p>Ribosomes are small structures where proteins are made. Although they are not enclosed within a membrane, they are frequently considered organelles. Each <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2074\">ribosome<\/a> is formed of two subunits, like the ones pictured at the beginning of this section (Figure 4.6.1) and in\u00a0 Figure 4.6.6. Both subunits consist of proteins and RNA. mRNA from the nucleus carries the genetic code, copied from DNA, which remains in the nucleus. At the ribosome, the genetic code in mRNA is used to assemble and join together amino acids to make proteins. Ribosomes can be found alone or in groups within the cytoplasm, as well as on the rER.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.6 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>An <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2083\">organelle<\/a> is a structure within the cytoplasm of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1573\">eukaryotic<\/a> cell that is enclosed within a membrane and performs a specific job. Although <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2074\">ribosomes<\/a>\u00a0are not enclosed within a membrane, they are still commonly referred to as organelles in eukaryotic cells.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2402\">nucleus<\/a> is the largest organelle in a eukaryotic cell, and it is considered to be the cell's control center. It controls\u00a0gene expression, including controlling which proteins the cell makes.<\/li>\n<li>The mitochondrion (plural, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2383\">mitochondria<\/a>) is an organelle that makes energy available to the cells. It is like the power plant of the cell. According to the widely accepted <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1986\">endosymbiotic theory<\/a>, mitochondria evolved from prokaryotic cells that were once free-living organisms that infected or were engulfed by larger prokaryotic cells.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2335\">endoplasmic reticulum<\/a> (ER) is an organelle that helps make and transport proteins and lipids. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2145\">Rough endoplasmic reticulum<\/a> (rER) is studded with ribosomes. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2101\">Smooth endoplasmic reticulum<\/a> (sER) has no ribosomes.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1991\">Golgi apparatus<\/a> is a large organelle that processes proteins and prepares them for use both inside and outside the cell. It is also involved in the transport of lipids around the cell.<\/li>\n<li>Both\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2437\">vesicles<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2430\">vacuoles<\/a>\u00a0are sac-like organelles that may be used to store and transport materials in the cell or as chambers for\u00a0biochemical reactions. Lysosomes and peroxisomes are special types of vesicles that break down foreign matter, dead cells, or poisons.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2093\">Centrioles<\/a> are organelles located near the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2402\">nucleus<\/a> that help organize the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2166\">chromosomes<\/a>\u00a0before\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2186\">cell division<\/a>\u00a0so each daughter cell receives the correct number of chromosomes.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2074\">Ribosomes<\/a>\u00a0are small structures where proteins are made. They are found in both\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1572\">prokaryotic<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1573\">eukaryotic<\/a> cells. They may be found alone or in groups within the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1963\">cytoplasm<\/a> or on the rER.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.6 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is an\u00a0organelle?<\/li>\n<li>Describe the structure and function of the nucleus.<\/li>\n<li>Explain how the nucleus, ribosomes, rough endoplasmic reticulum, and Golgi apparatus work together to make and transport proteins.<\/li>\n<li>Why are mitochondria referred to as the \"power plants of the cell\"?<\/li>\n<li>What roles are played by\u00a0vesicles and vacuoles?<\/li>\n<li>Why\u00a0do all cells need ribosomes \u2014 even prokaryotic cells that lack a nucleus and other\u00a0cell organelles?<\/li>\n<li>Explain endosymbiotic theory as it relates to mitochondria. What is one piece of evidence that supports this theory?<\/li>\n<li>\n<div id=\"h5p-39\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-39\" class=\"h5p-iframe\" data-content-id=\"39\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Cell Organelles\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.6 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\" style=\"text-align: center\">\n<p>https:\/\/www.youtube.com\/watch?v=URUJD5NEXC8&amp;t=121s<\/p>\n<p>Biology: Cell Structure I Nucleus Medical Media, Nucleus Medical Media, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=Id2rZS59xSE&amp;feature=youtu.be<\/p>\n<p>David Bolinsky: Visualizing the wonder of a living cell, TED, 2007.<\/p>\n<\/div>\n<\/div>\n<h2>Attributes<\/h2>\n<p><strong>Figure 4.6.1\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/pedrik\/3534019319\" rel=\"cc:attributionURL\">Ribosomes at Work<\/a> by <a class=\"owner-name truncate\" title=\"Go to pedrik's photostream\" href=\"https:\/\/www.flickr.com\/photos\/pedrik\/\" data-track=\"attributionNameClick\">Pedrik<\/a> on <a href=\"https:\/\/www.flickr.com\/\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 4.6.2<\/strong><\/p>\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Cell_nucleus#\/media\/File:Blausen_0212_CellNucleus.png\" rel=\"cc:attributionURL\">Nucleus<\/a> <span style=\"text-align: initial;font-size: 1em\">by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 4.6.3\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Mitochondrion_structure.svg\" rel=\"cc:attributionURL\">Mitochondrion_structure.svg<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kelvin13\">Kelvinsong<\/a>; modified by <a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Sowlos&amp;action=edit&amp;redlink=1\">Sowlos<\/a> on Wikimedia Commons is used and adapted by Christine Miller under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license.<\/p>\n<p><strong>Figure 4.6.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Endomembrane_system_diagram_en.svg\" rel=\"cc:attributionURL\">Endomembrane_system_diagram_en.svg<\/a> by Mariana Ruiz [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain <\/a>(https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figur<span style=\"font-size: 1em\">e 4.6.5<\/span><\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0214_Centrioles.png\" rel=\"cc:attributionURL\">Centrioles<\/a> <span style=\"text-align: initial;font-size: 1em\">by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 4.6.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Ribosome_shape.png\" rel=\"cc:attributionURL\">Ribosome_shape<\/a> by <a title=\"User:Vossman\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Vossman\">Vossman<\/a> on Wikimedia Commons is used and adapted by Christine Miller under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Nucleus - Medical gallery of Blausen Medical 2014. <i>WikiJournal of Medicine<\/i>\u00a01\u00a0(2).\u00a0DOI:10.15347\/wjm\/2014.010.\u00a0ISSN\u00a02002-4436. https:\/\/en.wikiversity.org\/wiki\/WikiJournal_of_Medicine\/Medical_gallery_of_Blausen_Medical_2014<\/p>\n<p class=\"hanging-indent\">Blausen.com staff (2014). Centrioles - Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.https:\/\/en.wikiversity.org\/wiki\/WikiJournal_of_Medicine\/Medical_gallery_of_Blausen_Medical_2014<\/p>\n<p class=\"hanging-indent\">Nucleus Medical Media. (2015, March 18). Biology: Cell structure I Nucleus Medical Media. YouTube. https:\/\/www.youtube.com\/watch?v=URUJD5NEXC8&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED. (2007, July 24). David Bolinsky: Visualizing the wonder of a living cell. YouTube. https:\/\/www.youtube.com\/watch?v=Id2rZS59xSE&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_2937\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_2937\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-455\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Free_Awesome_Girl_With_Braces_Close_Up.jpg\" alt=\"\" width=\"400\" height=\"409\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.1 Brace yourself!\u00a0<\/em><\/figcaption><\/figure>\n<h1>Oh, the Agony!<\/h1>\n<p>Wearing braces can be very uncomfortable, but it is usually worth it. Braces and other orthodontic treatments can re-align the teeth and jaws to improve bite and appearance. Braces can change the position of the teeth and the shape of the jaws because the human body is malleable. Many phenotypic traits \u2014 even those that have a strong genetic basis \u2014 can be molded by the environment. Changing the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2477\">phenotype<\/a> in response to the environment is just one of several ways we respond to environmental stress.<\/p>\n<div>\n<h1>Types of Responses to Environmental Stress<\/h1>\n<\/div>\n<p>There are four different types of responses that humans may make to cope with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2653\">environmental stress<\/a>:<\/p>\n<ol>\n<li>Adaptation<\/li>\n<li>Developmental adjustment<\/li>\n<li>Acclimatization<\/li>\n<li>Cultural responses<\/li>\n<\/ol>\n<p>The first three types of responses are biological in nature, and the fourth type is cultural. Only adaptation involves genetic change and occurs at the level of the population or species. The other three responses do not require genetic change, and they occur at the individual level.<\/p>\n<div>\n<h1>Adaptation<\/h1>\n<\/div>\n<p>An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2486\">adaptation<\/a><\/strong>\u00a0is a genetically-based trait that has evolved because it helps living things survive and reproduce in a given environment. Adaptations generally evolve in a population over many generations in response to stresses that last for a long period of time. Adaptations come about through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2633\">natural selection<\/a>. Those individuals who inherit a trait that confers an advantage in coping with an environmental stress are likely to live longer and reproduce more. As a result, more of their genes pass on to the next generation. Over many generations, the genes and the trait they control become more frequent in the population.<\/p>\n<h2>A Classic Example: Hemoglobin S and Malaria<\/h2>\n<p>Probably the most frequently-cited example of a genetic adaptation to an environmental stress is sickle cell trait. As you read in the previous section, people with sickle cell trait have one abnormal allele (S) and one normal allele (A) for hemoglobin, the red blood cell protein that carries oxygen in the blood. Sickle cell trait is an adaptation to the environmental stress of malaria, because people with the trait have resistance to this parasitic disease. In areas where malaria is endemic (present year-round), the sickle cell trait and its <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1942\">allele<\/a> have evolved to relatively high frequencies. \u00a0It is a classic example of natural selection favoring <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2474\">heterozygotes<\/a> for a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2035\">gene<\/a> with two <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1942\">alleles<\/a>. This type of selection keeps both alleles at relatively high frequencies in a population.<\/p>\n<h2>To Taste or Not to Taste<\/h2>\n<p>Another example of an adaptation in humans is the ability to taste bitter compounds. Plants produce a variety of toxic compounds in order to protect themselves from being eaten, and these toxic compounds often have a bitter taste. The ability to taste bitter compounds is thought to have evolved as an adaptation, because it prevented people from eating poisonous plants. Humans have many different genes that code for bitter taste receptors, allowing us to taste a wide variety of bitter compounds.<\/p>\n<p>A harmless bitter compound\u00a0called\u00a0<strong>phenylthiocarbamide (PTC)<\/strong>\u00a0is not found naturally in plants, but it is similar to toxic bitter compounds that\u00a0<em>are<\/em> found in plants. Humans' ability to taste this harmless substance has been tested in many different populations. In virtually every population studied, there are some people who can taste PTC (called tasters), and some people who cannot taste PTC, (called nontasters). The ratio of tasters to non-tasters varies among populations, but on average, 75 per cent of people can taste PTC and 25 per cent cannot.<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 272px\" class=\"wp-caption alignright\"><img class=\" wp-image-456\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Tongue.jpg\" alt=\"Tongue\" width=\"272\" height=\"288\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.2 The tiny red dots on the surface of the tongue consist of clumps of taste buds that contain receptor proteins for certain chemicals. We can taste those chemicals that bind strongly with any of the receptors.<\/em><\/figcaption><\/figure>\n<p>Like many scientific discoveries, human variation in PTC-taster status was discovered by chance. Around 1930, a chemist named Arthur Fox was working with powdered PTC in his lab. Some of the powder accidentally blew into the air. Another lab worker noticed that the powdered PTC tasted bitter, but Fox couldn't detect any taste at all. Fox wondered\u00a0how to explain\u00a0this difference in PTC-tasting ability. Geneticists soon determined that PTC-taster status is controlled by a single <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2035\">gene<\/a> with two common alleles, usually represented by the letters\u00a0<em>T<\/em>\u00a0and\u00a0<em>t<\/em>. The\u00a0<em>T<\/em> allele encodes a chemical receptor protein (found in taste buds on the tongue, as illustrated in Figure 6.4.2) that can strongly bind to PTC. The other allele, <em>t<\/em>, encodes a version of the receptor protein that cannot bind as strongly to PTC. The particular combination of these two alleles that a person inherits determines whether the person finds PTC to taste very bitter (<em>TT<\/em>), somewhat bitter\u00a0<em>(Tt),<\/em>\u00a0or not bitter at all\u00a0<em>(tt).<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>If the ability to taste bitter compounds is advantageous, why does every human population studied contain a significant percentage of people who are nontasters?\u00a0Why has the nontasting allele been preserved in human populations at all? Some scientists hypothesize that the nontaster allele actually confers the ability to taste some other, yet-to-be identified, bitter compound in plants. People who inherit both alleles would presumably be able to taste a wider range of bitter compounds, so they would have the greatest ability to avoid plant toxins. In other words, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2474\">heterozygote<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2715\">genotype<\/a> for the taster gene would be the most fit and favored by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2633\">natural selection<\/a>.<\/p>\n<p>Most people no longer have to worry whether the plants they eat contain toxins. The produce you grow in your garden or buy at the supermarket consists of known varieties that are safe to eat. However, natural selection may still be at work in human populations for the PTC-taster gene, because PTC tasters may be more sensitive than nontasters to bitter compounds in tobacco and vegetables in the cabbage family (that is, cruciferous vegetables, such as the broccoli, cauliflower, and cabbage pictured in Figure 6.4.3).<\/p>\n<ul>\n<li>People who find PTC to taste very bitter are less likely to smoke tobacco, presumably because tobacco smoke has a stronger bitter taste to these individuals. In this case, selection would favor taster genotypes, because tasters would be more likely to avoid smoking and its serious health risks.<\/li>\n<li>Strong tasters find cruciferous vegetables to taste bitter. As a result, they may avoid eating these vegetables (and perhaps other foods, as well), presumably resulting in a diet that is less varied and nutritious. In this scenario, natural selection\u00a0might\u00a0work against taster genotypes.<\/li>\n<\/ul>\n<p><span style=\"text-align: initial;font-size: 1em\"><\/p>\n<div id=\"h5p-86\">\n<div class=\"h5p-content\" data-content-id=\"86\"><\/div>\n<\/div>\n<p><\/span><\/p>\n<p><em>Figure 6.4.3 Cruciferous vegetables.<\/em><\/p>\n<div>\n<h1>Developmental Adjustment<\/h1>\n<\/div>\n<p>It takes a relatively long time for genetic change in response to environmental stress to produce a population with adaptations. Fortunately, we can adjust to some environmental stresses more quickly by changing in nongenetic ways. One type of nongenetic response to stress is\u00a0<strong>developmental adjustment.<\/strong>\u00a0This refers to phenotypic change that occurs during development in infancy or childhood, and that may persist into adulthood. This type of change may be irreversible by adulthood.<\/p>\n<h2>Phenotypic Plasticity<\/h2>\n<p>Developmental adjustment is possible because humans have a high degree of\u00a0<strong>phenotypic plasticity,<\/strong>\u00a0which is\u00a0the ability to alter\u00a0the<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2477\"> phenotype<\/a> in response to changes in the environment. Phenotypic plasticity allows us to respond to changes that occur within our lifetime, and it is particularly important for species\u00a0(like our own)\u00a0that have a long generation time. With long generations, evolution of genetic adaptations may occur too slowly to keep up with changing environmental stresses.<\/p>\n<h2>Developmental Adjustment and Cultural Practices<\/h2>\n<p>Developmental adjustment may be the result of naturally occurring environmental stresses or cultural practices, including medical or dental treatments. Like our example at the beginning of this section, using braces to change the shape of the jaw and the position of the teeth is an example of a dental practice that brings about a developmental adjustment. Another example of developmental adjustment is the use of a back brace to treat scoliosis (see images in <em>Figure 6.4.4<\/em>). Scoliosis is an abnormal curvature from side to side in the spine. If the problem is not too severe, a brace, if worn correctly, should prevent the curvature from worsening as a child grows, although it cannot straighten a curve that is already present. Surgery may be required to do that.<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 651px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-457\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg.png\" alt=\"\" width=\"651\" height=\"342\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.4 Scoliosis can be prevented from worsening by shaping the phenotype with a back brace.<\/em><\/figcaption><\/figure>\n<h2>Developmental Adjustment and Nutritional Stress<\/h2>\n<p>An important example of developmental adjustment that results from a naturally occurring environmental stress is the cessation of physical growth that occurs in children who are under nutritional stress. Children who lack adequate food to fuel both growth and basic metabolic processes are likely to slow down in their growth rate \u2014 or even to stop growing entirely. Shunting all available calories and nutrients into essential life functions may keep the child alive at the expense of increasing body size.<\/p>\n<p>Table 6.4.1 shows the effects of inadequate diet on children's' growth in several countries worldwide. For each country, the table gives the prevalence of <strong>stunting<\/strong>\u00a0in children under\u00a0the age of five. Children are considered stunted if their height is at least two standard deviations below the median height for their age in an international reference population.<\/p>\n<p><strong>Table 6.4.1<\/strong><\/p>\n<p><em>Percentage of Stunting in Young Children in Selected Countries (2011-2015)<\/em><\/p>\n<table class=\"grid aligncenter\" style=\"border-collapse: collapse;width: 53.0094%;height: 142px\" border=\"0\">\n<tbody>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 52.9369%;text-align: center\" colspan=\"2\"><strong>Percentage of Stunting in Young Children in Selected Countries (2011-2015)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 16px\">\n<td style=\"height: 16px;width: 22.19%\"><strong>Country<\/strong><\/td>\n<td style=\"height: 16px;width: 30.7469%\"><strong>Per cent of Children Under Age 5 with Stunting<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">United States<\/td>\n<td style=\"height: 14px;width: 30.7469%\">2.1<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Turkey<\/td>\n<td style=\"height: 14px;width: 30.7469%\">9.5<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Mexico<\/td>\n<td style=\"height: 14px;width: 30.7469%\">13.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Thailand<\/td>\n<td style=\"height: 14px;width: 30.7469%\">16.3<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Iraq<\/td>\n<td style=\"height: 14px;width: 30.7469%\">22.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Philippines<\/td>\n<td style=\"height: 14px;width: 30.7469%\">33.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Pakistan<\/td>\n<td style=\"height: 14px;width: 30.7469%\">45.0<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Papua New Guinea<\/td>\n<td style=\"height: 14px;width: 30.7469%\">49.5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>After a growth slow-down occurs and if adequate food becomes available, a child may be able to make up the loss of growth. If food is plentiful, the child may grow more rapidly than normal until the original, genetically-determined growth trajectory is reached. If the inadequate diet persists, however, the failure of growth may become chronic, and the child may never reach his or her full potential adult size.<\/p>\n<p>Phenotypic plasticity of body size in response to dietary change has been observed in successive generations within populations. For example, children in Japan were taller, on average, in each successive generation\u00a0after\u00a0the end of World War II. Boys aged 14-15 years old in 1986 were an average of about 18 cm (7 in.) taller than boys of the same age in 1959, a generation earlier. This is a highly significant difference, and it occurred too quickly to be accounted for by genetic change. Instead, the increase in height is a developmental adjustment, thought to be largely attributable to changes in the Japanese diet since World War II. During this period, there was an increase in the amount of animal protein and fat, as well as in the total calories consumed.<\/p>\n<div>\n<h1>Acclimatization<\/h1>\n<\/div>\n<p>Other responses to environmental stress are reversible and not permanent, whether they occur in childhood or adulthood. The development of reversible changes to environmental stress is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2483\">acclimatization<\/a>.<\/strong>\u00a0Acclimatization generally develops over a relatively short period of time.\u00a0It may take just a few days or weeks to attain a maximum response to a stress. When the stress is no longer present, the acclimatized state declines, and the body returns to its normal baseline state. Generally, the shorter the time for acclimatization to occur, the more quickly the condition is reversed when the environmental stress is removed.<\/p>\n<h2>Acclimatization to UV Light<\/h2>\n<p>A common example of acclimatization is tanning of the skin (see Figure 6.4.5). This occurs in many people in response to exposure to ultraviolet radiation from the sun. Special pigment cells in the skin, called melanocytes, produce more of the brown pigment melanin when exposed to sunlight. The melanin collects near the surface of the skin where it absorbs UV radiation so it cannot penetrate and potentially damage deeper skin structures. Tanning is a reversible change in the phenotype that helps the body deal temporarily with the environmental stress of high levels of UV radiation. When the skin is no longer exposed to the sun\u2019s rays, the tan fades, generally over a period of a few weeks or months.<\/p>\n<div id=\"h5p-87\">\n<div class=\"h5p-content\" data-content-id=\"87\"><\/div>\n<\/div>\n<p><em>Figure 6.4.5 Tanning of the skin occurs in many people in response to exposure to ultraviolet radiation from the sun.<\/em><\/p>\n<div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Acclimatization to Heat<\/span><\/p>\n<\/div>\n<p>Another common example of acclimatization occurs in response to heat. Changes that occur with heat acclimatization include increased sweat output and earlier onset of sweat production, which helps the body stay cool because evaporation of sweat takes heat from the body\u2019s surface in a process called evaporative cooling. It generally takes a couple of weeks for maximum heat acclimatization to come about by gradually working out harder and longer at high air temperatures. The changes that occur with acclimatization just as quickly subside when the body is no longer exposed to excessive heat.<\/p>\n<h2>Acclimatization to High Altitude<\/h2>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 420px\" class=\"wp-caption alignleft\"><img class=\" wp-image-458\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nepalese-base-camp-by-Mark-Horrell-on-Flickr-CC-BY-NC-SA-.jpg\" alt=\"Base camp in Nepal\" width=\"420\" height=\"315\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.6 Mountaineers must spend 4-5 days acclimatizing to high altitude before attempting to climb to the summit of Mount Everest.<\/em><\/figcaption><\/figure>\n<p>Short term acclimatization to high altitude occurs as a response to low levels of oxygen in the blood.\u00a0 This reduced level of oxygen is detected by carotid bodies, which will trigger in increase in breathing and heart rate.\u00a0 Over a period of weeks the body will compensate by increasing red blood cell production, thereby improving the oxygen-carrying capacity of the blood.\u00a0 This is why mountaineers wishing to climb to the peak of Mount Everest must complete the full climb in portions; it is recommended that climbers spend 2-3 days acclimatizing for every 600 metres of elevation increase.\u00a0 In addition, the higher to altitude, the longer it make take to acclimatize; climbers are advised to spend 4-5 days acclimatizing at base camp (whether the base camp in Nepal or China) before completing the final leg of the climb to the peak.\u00a0 The concentration of red blood cells gradually decreases to normal levels once a climber returns to their normal elevation.<\/p>\n<div>\n<h1>Cultural Responses<\/h1>\n<\/div>\n<p>More than any other species, humans respond to environmental stresses with learned behaviors and technology. These cultural responses allow us to change our environments to control stresses, rather than changing our bodies genetically or physiologically to cope with the stresses. Even archaic humans responded to some environmental stresses in this way. For example, Neanderthals used shelters, fires, and animal hides as clothing to stay warm in the cold climate in Europe during the last ice age. Today, we use more sophisticated technologies to stay warm in cold climates while retaining our essentially tropical-animal anatomy and physiology. We also use technology (such as furnaces and air conditioners) to avoid temperature stress and stay comfortable in hot or cold climates.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Humans may respond to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2653\">environmental stress <\/a>in four different ways: adaptation, developmental adjustment, acclimatization, and cultural responses.<\/li>\n<li>An adaptation is a genetically based trait that has evolved because it helps living things survive and reproduce in a given environment. Adaptations evolve by natural selection in populations over a relatively long period to time. Examples of adaptations include sickle cell trait as an adaptation to the stress of endemic malaria and the ability to taste bitter compounds as an adaptation to the stress of bitter-tasting toxins in plants.<\/li>\n<li>A developmental adjustment is a non-genetic response to stress that occurs during infancy or childhood, and that may persist into adulthood. This type of change may be irreversible. Developmental adjustment is possible because humans have a high degree of phenotypic plasticity. It may be the result of environmental stresses (such as inadequate food), which may stunt growth, or cultural practices (such as orthodontic treatments), which re-align the teeth and jaws.<\/li>\n<li>Acclimatization is the development of reversible changes to environmental stress that develop over a relatively short period of time. The changes revert to the normal baseline state after the stress is removed. Examples of acclimatization include tanning of the skin and physiological changes (such as increased sweating) that occur with heat acclimatization.<\/li>\n<li>More than any other species, humans respond to environmental stress with learned behaviors and technology, which are cultural responses. These responses allow us to change our environment to control stress, rather than changing our bodies genetically or physiologically to cope with stress. Examples include using shelter, fire, and clothing to cope with a cold climate.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>List four different types of responses that humans may make to cope with environmental stress.<\/li>\n<li>Define adaptation.<\/li>\n<li>\n<div id=\"h5p-88\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-88\" class=\"h5p-iframe\" data-content-id=\"88\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Human Responses to Environmental Stress\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Explain how natural selection may have resulted in most human populations having people who can and people who cannot taste PTC.<\/li>\n<li>What is a developmental adjustment?<\/li>\n<li>Define phenotypic plasticity.<\/li>\n<li>Explain why phenotypic plasticity may be particularly important in a species with a long generation time.<\/li>\n<li>Why may stunting of growth occur in children who have an inadequate diet? Why is stunting preferable to the alternative?<\/li>\n<li>What is acclimatization?<\/li>\n<li>How does acclimatization to heat come about, and what are two physiological changes that occur in heat acclimatization?<\/li>\n<li>Give an example of a cultural response to heat stress.<\/li>\n<li>Which is more likely to be reversible \u2014 a change due to acclimatization, or a change due to developmental adjustment? Explain your answer.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=upp9-w6GPhU<\/p>\n<p style=\"text-align: center\">Could we survive prolonged space travel? - Lisa Nip, TED-Ed, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=hRnrIpUMyZQ&amp;t=182s<\/p>\n<p style=\"text-align: center\">How this disease changes the shape of your cells - Amber M. Yates, TED-Ed, 2019.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 6.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Free_Awesome_Girl_With_Braces_Close_Up.jpg\" rel=\"cc:attributionURL\">Free_Awesome_Girl_With_Braces_Close_Up<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/people\/40645538@N00\" rel=\"nofollow\">D. Sharon Pruitt<\/a> from Hill Air Force Base, Utah, USA on Wikimedia Commons is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en) license.<\/p>\n<p><strong>Figure 6.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:%D8%B2%D8%A8%D8%A7%D9%86_tongue.jpg\" rel=\"cc:attributionURL\">Tongue<\/a> by <a class=\"new\" title=\"User:Mahdiabbasinv (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Mahdiabbasinv&amp;action=edit&amp;redlink=1\">Mahdiabbasinv<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en) license.<\/p>\n<p><strong>Figure 6.4.3<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/unsplash.com\/photos\/PT-GXFtQj-s\">White cauliflower on brown wooden chopping board<\/a> by <a href=\"https:\/\/unsplash.com\/@louishansel\">Louis Hansel @shotsoflouis<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/LpHYbY6Qu_o\">Broccoli on wooden chopping board<\/a> by <a href=\"https:\/\/unsplash.com\/@louishansel\">Louis Hansel @shotsoflouis<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/knGwkn2j4ro\">Green cabbage close up<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@photoliphecjd\">Craig Dimmick<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/2Qzk3EJLNGE\">Cabbage hybrid\/ brussel sprouts<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@darkersolstice\">Solstice Hannan<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/_zV74zUnwmc\">Kale<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@lauramakoj\">Laura Johnston<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/v25z8P-CPB4\">Tiny bok choy at the Asian market<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@twoluckyspoons\">Jodie Morgan<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<\/ul>\n<p><strong>Figure 6.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg.png\" rel=\"cc:attributionURL\">Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg<\/a> by Weiss H.R. from <a href=\"https:\/\/scoliosisjournal.biomedcentral.com\/articles\/10.1186\/1748-7161-2-19\">Scoliosis Journal\/BioMed Central Ltd<\/a>. on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 6.4.5<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/21077319@N02\/3667901661\">Tan Lines<\/a> by <a class=\"owner-name truncate\" title=\"Go to k.steudel's photostream\" href=\"https:\/\/www.flickr.com\/photos\/snaks\/\" data-track=\"attributionNameClick\">k.steudel<\/a> on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/3760162521\/sizes\/l\/\">Twin tan lines (all sizes)<\/a> by <a class=\"owner-name truncate\" title=\"Go to Quinn Dombrowski's photostream\" href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/\" data-track=\"attributionNameClick\">Quinn Dombrowski<\/a>\u00a0on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/14518898810\">Wedding ring tan line<\/a> by <a class=\"owner-name truncate\" title=\"Go to Quinn Dombrowski's photostream\" href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/\" data-track=\"attributionNameClick\">Quinn Dombrowski<\/a>\u00a0on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/29333334@N06\/3792695572\">Tan<\/a> by <a class=\"owner-name truncate\" title=\"Go to Evil Erin's photostream\" href=\"https:\/\/www.flickr.com\/photos\/evilerin\/\" data-track=\"attributionNameClick\">Evil Erin<\/a> on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<\/ul>\n<p><strong style=\"text-align: initial;font-size: 1em\">Figure 6.4.6<\/strong><\/p>\n<p><a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/www.flickr.com\/photos\/markhorrell\/18787430274\/in\/photostream\/\" rel=\"cc:attributionURL\">Nepalese base camp<\/a> by <a class=\"owner-name truncate\" title=\"Go to Mark Horrell's photostream\" href=\"https:\/\/www.flickr.com\/photos\/markhorrell\/\" data-track=\"attributionNameClick\">Mark Horrell<\/a><span style=\"text-align: initial;font-size: 1em\">\u00a0on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a\u00a0<\/span><a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">TED-Ed. (2016, October 4). Could we survive prolonged space travel? - Lisa Nip. YouTube. https:\/\/www.youtube.com\/watch?v=upp9-w6GPhU&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2019, May 6). How this disease changes the shape of your cells - Amber M. Yates. YouTube. https:\/\/www.youtube.com\/watch?v=hRnrIpUMyZQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Weiss, H. (2007). Is there a body of evidence for the treatment of patients with Adolescent Idiopathic Scoliosis (AIS)? [Figure 2 - digital photograph],\u00a0 <i>Scoliosis, <\/i>2(19).\u00a0https:\/\/doi.org\/10.1186\/1748-7161-2-19<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5889\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5889\"><div tabindex=\"-1\"><p>The front lobe of the pituitary gland that synthesizes and secretes pituitary hormones.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3401\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3401\"><div tabindex=\"-1\"><p>A membrane protein involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5661\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5661\"><div tabindex=\"-1\"><p>A hormone is a signaling molecule produced by glands in multicellular organisms that target distant organs to regulate physiology and behavior.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_2958\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_2958\"><div tabindex=\"-1\"><p>Image shows a diagram of Thrombocytes in their normal state and activated.<br \/>\n Thrombocytes (platelets) are typically ovoid during normal circulation, but when activated become super fibrous.  The not activated platelets look like very smooth and the activated platelets look like sea anemones- lots of little projects sticking out of their surface.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3402\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3402\"><div tabindex=\"-1\"><p>A membrane protein involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_2702\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_2702\"><div tabindex=\"-1\"><p>Structures containing neuronal cell bodies in the peripheral nervous system.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3403\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3403\"><div tabindex=\"-1\"><p>accessory organ of the skin made of sheets of dead keratinocytes at the distal ends of the fingers and toes<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3404\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3404\"><div tabindex=\"-1\"><p>accessory organ of the skin made of sheets of dead keratinocytes at the distal ends of the fingers and toes<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3197\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3197\"><div tabindex=\"-1\"><p>Image shows a diagram of Killer T Cell funtion.  An infected cell displays a pathogen antigen on an MHC.  The Killer T Cell interacts with the MHC and in response produces perforin ( a protein that pokes holes in cell membranes) and granzymes (proteins that instruct a cell to carry out programmed cell death). The infected cell dies from the combination of these substances, and as it dies, so does the pathogen inside the infected cell.  The Killer T Cell is free to move on and find and destroy other infected cells.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_2590\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_2590\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4378\" aria-describedby=\"caption-attachment-4378\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4378\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/aircraft-1583871_1920-1.jpg\" alt=\"14.1.1 Airplane Exercise\" width=\"400\" height=\"226\"><figcaption id=\"caption-attachment-4378\" class=\"wp-caption-text\"><em>Figure 14.1.1 Got to keep that blood moving!<\/em><\/figcaption><\/figure>\n<div>\n<h1>Case Study: Flight Risk<\/h1>\n<\/div>\n<p>Nineteen-year-old Malcolm is about to take his first plane flight. Shortly after he boards the plane and sits down, a man in his late sixties sits next to him in the aisle seat. About half an hour after the plane takes off, the pilot announces that she is turning the seat belt light off, and that it is safe to move around the cabin.<\/p>\n<p>The man in the aisle seat \u2014 who has introduced himself to Malcolm as Willie \u2014 immediately unbuckles his seat belt and paces up and down the aisle a few times before returning to his seat. After about 45 minutes, Willie gets up again, walks some more, then sits back down and does some foot and leg exercises. After the third time Willie gets up and paces the aisles, Malcolm asks him whether he is walking so much to accumulate steps on a pedometer or fitness tracking device. Willie laughs and says no. He is actually trying to do something even more important for his health \u2014 prevent a blood clot from forming in his legs.<\/p>\n<p>Willie explains that he has a chronic condition: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4219\">heart failure<\/a>. Although it sounds scary, his condition is currently well-managed, and he is able to lead a relatively normal lifestyle. However, it <em>does<\/em> put him at risk of developing other serious health conditions, such as deep vein thrombosis (DVT), which is when a blood clot occurs in the deep veins, usually in the legs. Air travel \u2014\u00a0and\u00a0other situations where a person has to sit for a long period of time \u2014 increases the risk of DVT. Willie\u2019s doctor said that he is healthy enough to fly, but that he should walk frequently and do leg exercises to help avoid a blood clot.<\/p>\n<p>As you read this chapter, you will learn about the heart, blood vessels, and blood that make up the cardiovascular system, as well as disorders of the cardiovascular system, such as heart failure. At the end of the chapter you will learn more about why DVT occurs, why Willie has to take extra precautions when he flies, and what can be done to lower the risk of DVT and its potentially deadly consequences.<\/p>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter Overview: Cardiovascular System<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In this chapter, you will learn about the cardiovascular system, which transports substances throughout the body. Specifically, you will learn about:<\/p>\n<ul>\n<li>The major components of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2910\">cardiovascular system<\/a>: the heart, blood vessels, and blood.<\/li>\n<li>The functions of the cardiovascular system, including transporting needed substances (such as oxygen and nutrients) to the cells of the body, and picking up waste products.<\/li>\n<li>How blood is oxygenated through the pulmonary circulation, which transports blood between the heart and lungs.<\/li>\n<li>How blood is circulated throughout the body through the systemic circulation.<\/li>\n<li>The components of blood \u2014 including plasma, red blood cells, white blood cells, and platelets \u2014 and their specific functions.<\/li>\n<li>Types of blood vessels \u2014 including arteries, veins, and capillaries \u2014 and their functions, similarities, and differences.<\/li>\n<li>The structure of the heart, how it pumps blood, and how contractions of the heart are controlled.<\/li>\n<li>What blood pressure is and how it is regulated.<\/li>\n<li>Blood disorders, including anemia, HIV, and leukemia.<\/li>\n<li>Cardiovascular diseases (including heart attack, stroke, and angina), and the risk factors and precursors \u2014 such as high blood pressure and atherosclerosis \u2014 that contribute to them.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox shaded\">\n<p>As you read the chapter, think about the following questions:<\/p>\n<ol>\n<li>What is heart failure?Why\u00a0do you think it increases the risk of DVT?<\/li>\n<li>What is a blood clot? What are possible health consequences of blood clots?<\/li>\n<li>Why do you think sitting for long periods of time increases the risk of DVT? Why does walking and exercising the legs help reduce this risk?<\/li>\n<\/ol>\n<\/div>\n<h2>Attribution<\/h2>\n<p><strong>Figure 14.1.1<\/strong><\/p>\n<p><a href=\"https:\/\/pixabay.com\/photos\/aircraft-interior-seats-1583871\/\" rel=\"cc:attributionURL\">aircraft-1583871_1920<\/a> [photo] by <a href=\"https:\/\/pixabay.com\/users\/olivier89-3075816\/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=1583871\" rel=\"dc:creator\">olivier89<\/a> from <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/de\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/de\/service\/license\/).<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_6043\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_6043\"><div tabindex=\"-1\"><p>A peptide hormone, produced by alpha cells of the pancreas. It works to raise the concentration of glucose and fatty acids in the bloodstream, and is considered to be the main catabolic hormone of the body. It is also used as a medication to treat a number of health conditions.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5451\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5451\"><div tabindex=\"-1\"><p>Glucose (also called dextrose) is a simple sugar with the molecular formula C6H12O6. Glucose is the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, using energy from sunlight.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5757\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5757\"><div tabindex=\"-1\"><p>Biological molecules that lower amount the energy required for a reaction to occur.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5869\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5869\"><div tabindex=\"-1\"><p>one of a pair of glands located on top of the kidneys that secretes hormones such as cortisol and adrenaline<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_2988\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_2988\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_1172\" aria-describedby=\"caption-attachment-1172\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4285\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Exhale-by-pavel-lozovikov-HYovA7yPPvI-unsplash-scaled-1.jpg\" alt=\"13.2.1 Exhale\" width=\"400\" height=\"267\"><figcaption id=\"caption-attachment-1172\" class=\"wp-caption-text\"><em>Figure 13.2.1 Every breath you take...\u00a0<\/em><\/figcaption><\/figure>\n<div>\n<h1>Seeing Your Breath<\/h1>\n<\/div>\n<p>Why can you \u201csee your breath\u201d on a cold day? The air you exhale through your nose and mouth is warm like the inside of your body. Exhaled air also contains a lot of\u00a0water\u00a0vapor, because it passes over moist surfaces from the lungs to the nose or mouth. The water vapor in your breath cools suddenly when it reaches the much colder outside air. This causes the water vapor to condense into a\u00a0fog\u00a0of tiny droplets of\u00a0liquid\u00a0water. You release water vapor and other gases from your body through the process of respiration.<\/p>\n<div>\n<h1>What is Respiration?<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4286\">Respiration<\/a><\/strong>\u00a0is the life-sustaining process in which gases are exchanged between the body and the outside atmosphere. Specifically, oxygen moves from the outside air into the body; and\u00a0water\u00a0vapor, carbon dioxide, and other waste gases move from inside the body to the outside air. Respiration is carried out mainly by the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2912\">respiratory system<\/a><\/strong><strong>.<\/strong>\u00a0It is important to note that respiration by the\u00a0respiratory system\u00a0is not the same process as\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2305\">cellular respiration<\/a>\u00a0\u2014which occurs inside\u00a0cells\u00a0\u2014 although the two processes are closely connected. Cellular respiration is the metabolic process in which cells obtain\u00a0energy, usually by \u201cburning\u201d glucose in the presence of oxygen. When cellular respiration is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1796\">aerobic<\/a>, it uses oxygen and releases carbon dioxide as a waste product. Respiration by the respiratory system supplies the oxygen needed by cells for aerobic cellular respiration, and removes the carbon dioxide produced by cells during cellular respiration.<\/p>\n<p>Respiration by the\u00a0respiratory system\u00a0actually involves two subsidiary processes. One process is\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4287\">ventilation<\/a><\/strong>, or\u00a0breathing.\u00a0Ventilation\u00a0is the physical process of conducting air to and from the lungs. The other process is\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4288\">gas exchange<\/a><\/strong>. This is the biochemical process in which oxygen diffuses out of the air and into the\u00a0blood, while carbon dioxide and other waste gases diffuse out of the blood and into the air. All of the organs of the respiratory system are involved in\u00a0breathing, but only the lungs are involved in\u00a0gas exchange.<\/p>\n<div>\n<h1>Respiratory Organs<\/h1>\n<\/div>\n<p>The organs of the respiratory system form a continuous system of passages, called the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4289\">respiratory tract<\/a>,<\/strong> through which air flows into and out of the body. The respiratory tract has two major divisions: the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4290\">upper respiratory tract<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4291\">lower respiratory tract<\/a>. The organs in each division are shown in Figure 13.2.2. In addition to these organs, certain muscles of the thorax (body cavity that fills the chest) are also involved in respiration by enabling breathing. Most important is a large muscle called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4292\">diaphragm<\/a>, which lies below the lungs and separates the thorax from the abdomen. Smaller muscles between the ribs also play a role in breathing.<\/p>\n<figure id=\"attachment_1172\" aria-describedby=\"caption-attachment-1172\" style=\"width: 466px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1152\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Illu_conducting_passages.svg_.png\" alt=\"13.2.2 Respiratory Tract\" width=\"466\" height=\"600\"><figcaption id=\"caption-attachment-1172\" class=\"wp-caption-text\"><em>Figure 13.2.2 During breathing, inhaled air enters the body through the nose and passes through the respiratory tract to the lungs. Exhaled air travels from the lungs in the opposite direction.<\/em><\/figcaption><\/figure>\n<h2>Upper Respiratory Tract<\/h2>\n<p>All of the organs and other structures of the upper respiratory tract are involved in\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4294\">conduction<\/a><\/strong>, or the movement of air into and out of the body. Upper respiratory tract organs provide a route for air to move between the outside atmosphere and the lungs. They also clean, humidify, and warm the incoming air. No gas exchange occurs in these organs.<\/p>\n<h3>Nasal Cavity<\/h3>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4295\">nasal cavity<\/a><\/strong>\u00a0is a large, air-filled space in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3957\">skull<\/a> above and behind the nose in the middle of the face. It is a continuation of the two nostrils. As inhaled air flows through the nasal cavity, it is warmed and humidified by blood vessels very close to the surface of this epithelial tissue . Hairs in the nose and mucous produced by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3538\">mucous membrane<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0help trap larger foreign particles in the air before they go deeper into the respiratory tract. In addition to its respiratory functions, the nasal cavity also contains <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3128\">chemoreceptor<\/span><span style=\"text-align: initial;font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0 needed for sense of smell, and contribution to the sense of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_3157\">taste<\/a>.<\/span><\/p>\n<h3>Pharynx<\/h3>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4296\">pharynx<\/a><\/strong>\u00a0is a tube-like structure that connects the nasal cavity and the back of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4297\">mouth<\/a> to other structures lower in the throat, including the larynx. The pharynx has dual functions \u2014 both air and food (or other swallowed substances) pass through it, so it is part of both the respiratory and the digestive systems. Air passes from the nasal cavity through the pharynx to the larynx (as well as in the opposite direction). Food passes from the mouth through the pharynx to the esophagus.<\/p>\n<h3>Larynx<\/h3>\n<p style=\"text-align: left\">The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4298\">larynx<\/a><\/strong> connects the pharynx and trachea, and helps to conduct air through the respiratory tract. The larynx is also called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4299\">voice box<\/a>, because it contains the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4320\">vocal cords<\/a>, which vibrate when air flows over them, thereby producing sound. You can see the vocal cords in the larynx in Figures 13.2.3 and 13.2.4. Certain muscles in the larynx move the vocal cords apart to allow breathing. Other muscles in the larynx move the vocal cords together to allow the production of vocal sounds. The latter muscles also control the pitch of sounds and help control their volume.<\/p>\n<table class=\" aligncenter\" style=\"border-collapse: collapse;width: 95.0523%;height: 10px\" border=\"0\">\n<tbody>\n<tr style=\"height: 50px\">\n<td style=\"width: 50%;height: 10px\">\n<figure id=\"attachment_1155\" aria-describedby=\"caption-attachment-1155\" style=\"width: 392px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1155\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/larynx.jpg\" alt=\"13.2.3 Larynx external view\" width=\"392\" height=\"314\"><figcaption id=\"caption-attachment-1155\" class=\"wp-caption-text\"><em>Figure 13.2.3 The larynx as viewed from externally.<\/em><\/figcaption><\/figure>\n<\/td>\n<td style=\"width: 53.5346%;height: 10px;text-align: left\">&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><img class=\"wp-image-1157\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Larynx-top-view-nci-vol-4370-72.jpg\" alt=\"13.2.4 Larynx top view\" width=\"330\" height=\"297\"><\/p>\n<p><em>Figure 13.2.4 The larynx as viewed from the top.<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: left\">A very important function of the larynx is protecting the trachea from aspirated food. When swallowing occurs, the backward motion of the tongue forces a flap called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4302\">epiglottis<\/a> to close over the entrance to the larynx. (You can see the epiglottis in both Figure 13.2.3 and 13.2.4.) This prevents swallowed material from entering the larynx and moving deeper into the respiratory tract. If swallowed material does start to enter the larynx, it irritates the larynx and stimulates a strong cough reflex. This generally expels the material out of the larynx, and into the throat.<\/p>\n<p>&nbsp;<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=BsyB88mq5rQ<\/p>\n<p style=\"text-align: center\">Larynx Model - Respiratory System, Dr. Lotz, 2018.<\/p>\n<h2>Lower Respiratory Tract<\/h2>\n<figure id=\"attachment_1172\" aria-describedby=\"caption-attachment-1172\" style=\"width: 294px\" class=\"wp-caption alignleft\"><img class=\"wp-image-1159\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2000px-Lungs_diagram_detailed.svg_.png\" alt=\"13.2.5 Branching in the lower respiratory tract\" width=\"294\" height=\"375\"><figcaption id=\"caption-attachment-1172\" class=\"wp-caption-text\"><em>Figure 13.2.5 This diagram illustrates the tree-like branching of the passages of the lower respiratory tract within the lungs.<\/em><\/figcaption><\/figure>\n<p>The trachea and other passages of the lower respiratory tract conduct air between the upper respiratory tract and the lungs. These passages form an inverted tree-like shape (Figure 13.2.5), with repeated branching as they move deeper into the lungs. All told, there are an astonishing 2,414 kilometres (1,500 miles) of airways conducting air through the human respiratory tract! It is only in the lungs, however, that gas exchange occurs between the air and the bloodstream.<\/p>\n<h3>Trachea<\/h3>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4304\">trachea<\/a>,<\/strong> or windpipe, is the widest passageway in the respiratory tract. It is about 2.5 cm wide and 10-15 cm long (approximately 1 inch wide and 4\u20136 inches long). It is formed by rings of cartilage, which make it relatively strong and resilient. The trachea connects the larynx to the lungs for the passage of air through the respiratory tract. The trachea branches at the bottom to form two bronchial tubes.<\/p>\n<h3>Bronchi and Bronchioles<\/h3>\n<p>There are two main bronchial tubes, or\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4309\">bronchi<\/a> (singular, bronchus)<\/strong>, called the right and left bronchi. The bronchi carry air between the trachea and lungs. Each bronchus branches into smaller, secondary bronchi; and secondary bronchi branch into still smaller tertiary bronchi. The smallest bronchi branch into very small tubules called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4310\">bronchiole<\/a>s. The tiniest bronchioles end in alveolar ducts, which terminate in clusters of minuscule\u00a0air sacs, called\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4311\"><strong>alveoli<\/strong>\u00a0<\/a>(singular, alveolus), in the lungs.<\/p>\n<h3>Lungs<\/h3>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2990\">lungs<\/a><\/strong>\u00a0are the largest organs of the respiratory tract. They are suspended within the pleural cavity of the thorax. The lungs are surrounded by two thin membranes called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4312\">pleura<\/a><\/strong>, which secrete fluid that allows the lungs to move freely within the pleural cavity. This is necessary so the lungs can expand and contract during breathing. In Figure 13.2.6, you can see that each of the two lungs is divided into sections. These are called lobes, and they are separated from each other by connective tissues. The right lung is larger and contains three lobes. The left lung is smaller and contains only two lobes. The smaller left lung allows room for the heart, which is just left of the center of the chest.<\/p>\n<figure id=\"attachment_1172\" aria-describedby=\"caption-attachment-1172\" style=\"width: 543px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1164\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Gross_Anatomy_of_the_Lungs.jpg\" alt=\"13.2.6 Anatomy of the Lung\" width=\"543\" height=\"373\"><figcaption id=\"caption-attachment-1172\" class=\"wp-caption-text\"><em>Figure 13.2.6 The lungs are separated into the right and left lung.<\/em><\/figcaption><\/figure>\n<div>\n<p>As mentioned previously, the bronchi terminate in bronchioles which feed air into alveoli, tiny sacs of simple squamous epithelial tissue which make up the bulk of the lung.\u00a0\u00a0The cross-section of lung tissue in the diagram below (Figure 13.2.7) shows the alveoli, in which gas exchange takes place with the capillary network that surrounds them.<\/p>\n<table class=\" aligncenter\" style=\"border-collapse: collapse;width: 49.2386%;height: 420px\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 100%\">\n<figure id=\"attachment_1166\" aria-describedby=\"caption-attachment-1166\" style=\"width: 515px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1166\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Alveoli-Structure.jpg\" alt=\"13.2.7 Alveoli Structure\" width=\"515\" height=\"343\"><figcaption id=\"caption-attachment-1166\" class=\"wp-caption-text\"><em>Figure 13.2.7 Alveoli make up the bulk of the lung and form millions of grape-like clusters of air sacs for the purpose of exchanging gases with capillaries of the cardiovascular system.<\/em><\/figcaption><\/figure>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 100%\">\n<figure id=\"attachment_1168\" aria-describedby=\"caption-attachment-1168\" style=\"width: 674px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1168\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/annotated_diagram_of_an_alveolus.svg_.png\" alt=\"13.2.8 Alveolus\" width=\"674\" height=\"506\"><figcaption id=\"caption-attachment-1168\" class=\"wp-caption-text\"><em>Figure 13.2.8 An alveolus in which gas exchange takes place with the capillary network that surrounds it. Surfactant is a liquid that covers the inside of the alveoli and prevents them from collapsing and sticking together when air empties out of them during exhalation.<\/em><\/figcaption><\/figure>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: center\">\n<\/div>\n<p>Lung tissue consists mainly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4311\">alveoli<\/a> (see Figures 13.2.7 and 13.2.8). These tiny air sacs are the functional units of the lungs where gas exchange takes place. The two lungs may contain as many as 700 million alveoli, providing a huge total surface area for gas exchange to take place. In fact, alveoli in the two lungs provide as much surface area as half a tennis court! Each time you breathe in, the alveoli fill with air, making the lungs expand. Oxygen in the air inside the alveoli is absorbed by the blood via diffusion in the mesh-like network of tiny capillaries that surrounds each alveolus. The blood in these capillaries also releases carbon dioxide (also by diffusion) into the air inside the alveoli. Each time you breathe out, air leaves the alveoli and rushes into the outside atmosphere, carrying waste gases with it.<\/p>\n<p>The lungs receive blood from two major sources. They receive deoxygenated blood from the right side of the heart. This blood absorbs oxygen in the lungs and carries it back to the left side heart to be pumped to cells throughout the body. The lungs also receive oxygenated blood from the heart that provides oxygen to the cells of the lungs for cellular respiration.<\/p>\n<div>\n<h1>Protecting the Respiratory System<\/h1>\n<\/div>\n<p>You may be able to survive for weeks without food and for days without\u00a0water, but you can survive without oxygen for only a matter of minutes \u2014 except under exceptional circumstances \u2014 so protecting the respiratory system is vital. Ensuring that\u00a0a patient has an open airway is the first step in treating many medical emergencies. Fortunately, the respiratory system is well protected by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2142\">ribcage<\/a> of the\u00a0skeletal system.\u00a0The extensive surface area of the respiratory system, however, is directly exposed to the outside world and all its potential dangers in inhaled air.\u00a0It\u00a0should come as no surprise that the respiratory system has a variety of ways to protect itself from harmful substances, such as dust and pathogens in the air.<\/p>\n<p>The main way the respiratory system protects itself is called the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4318\">mucociliary escalator<\/a><\/strong>. From the nose through the bronchi, the respiratory tract is covered in epithelium that contains mucus-secreting goblet\u00a0cells. The mucus traps particles and pathogens in the incoming air. The epithelium of the respiratory tract is also covered with tiny cell projections called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_1597\">cilia<\/a><\/strong> (singular, cilium), as shown in the animation. The cilia constantly move in a sweeping motion upward toward the throat, moving the mucus and trapped particles and pathogens away from the lungs and toward the outside of the body. The upward sweeping motion of cilia lining the respiratory tract helps keep it free from dust, pathogens, and other harmful substances.<\/p>\n<p>Watch \"Mucociliary clearance\" by I-Hsun Wu to learn more:<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=HMB6flEaZwI<\/p>\n<p style=\"text-align: center\">Mucociliary clearance, I-Hsun Wu, <span style=\"font-size: 1em\">2015.<\/span><\/p>\n<div id=\"flex\" class=\"style-scope ytd-video-primary-info-renderer\"><\/div>\n<div id=\"menu-container\" class=\"style-scope ytd-video-primary-info-renderer\">\n<div id=\"menu\" class=\"style-scope ytd-video-primary-info-renderer\"><\/div>\n<div id=\"container\" class=\"style-scope ytd-sentiment-bar-renderer\"><span style=\"font-size: 1em;text-align: initial\">What happens to the material that moves up the mucociliary escalator to the throat? It is generally removed from the respiratory tract by clearing the throat or coughing. Coughing is a largely involuntary response of the respiratory system that occurs when nerves lining the airways are irritated. The response causes air to be expelled forcefully from the trachea, helping to remove mucus and any debris it contains (called phlegm) from the upper respiratory tract to the mouth. The phlegm may be spit out (expectorated), or it may be swallowed and destroyed by stomach acids.<\/span><\/div>\n<div><\/div>\n<\/div>\n<div><\/div>\n<figure id=\"attachment_1172\" aria-describedby=\"caption-attachment-1172\" style=\"width: 385px\" class=\"wp-caption alignleft\"><img class=\"wp-image-1172\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Sneeze.jpg\" alt=\"13.2.9 Sneeze\" width=\"385\" height=\"258\"><figcaption id=\"caption-attachment-1172\" class=\"wp-caption-text\"><em>Figure 13.2.9 Sneezing results in tiny particles from the mouth being forcefully ejected into the air.<\/em><\/figcaption><\/figure>\n<p>Sneezing is a similar involuntary response that occurs when nerves lining the nasal passage are irritated. It results in forceful expulsion of air from the mouth, which sprays millions of tiny droplets of mucus and other debris out of the mouth and into the air, as shown in Figure 13.2.9. This explains why it is so important to sneeze into a tissue (rather than the air) if we are to prevent the transmission of respiratory pathogens.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">How the Respiratory System Works with Other Organ Systems<\/span><\/p>\n<p>The amount of oxygen and carbon dioxide in the blood must be maintained within a limited range for survival of the organism. Cells cannot survive for long without oxygen, and if there is too much carbon dioxide in the blood, the blood becomes dangerously <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2258\">acidic<\/a> (pH is too low). Conversely, if there is too little carbon dioxide in the blood, the blood becomes too basic (pH is too high). The respiratory system works hand-in-hand with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2908\">nervous<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2571\">cardiovascular<\/a> systems to maintain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2350\">homeostasis<\/a> in blood gases and pH.<\/p>\n<p>It is the level of carbon dioxide \u2014 rather than the level of oxygen \u2014 that is most closely monitored to maintain blood\u00a0gas\u00a0and\u00a0pH\u00a0homeostasis. The level of carbon dioxide in the blood is detected by cells in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_2554\">brain<\/a>, which\u00a0speed\u00a0up or slow down the rate of breathing through the autonomic\u00a0nervous system\u00a0as needed to bring the carbon dioxide level within the normal range. Faster breathing lowers the carbon dioxide level (and raises the oxygen level and pH), while slower breathing has the opposite effects. In this way, the levels of carbon dioxide, oxygen, and pH are maintained within normal limits.<\/p>\n<p>The respiratory system also works closely with the cardiovascular system to maintain homeostasis. The respiratory system exchanges gases with the outside air, but it needs the cardiovascular system to carry them to and from body cells. Oxygen is absorbed by the blood in the lungs and then transported through a vast network of blood vessels to cells throughout the body, where it is needed for aerobic cellular respiration. The same system absorbs carbon dioxide from cells and carries it to the respiratory system for removal from the body.<\/p>\n<div>\n<h1>Feature: My\u00a0Human Body<\/h1>\n<\/div>\n<p>Choking due to a foreign object becoming lodged in the airway results in nearly 5 thousand deaths in Canada each year. In addition, choking accounts for almost 40% of unintentional injuries in infants under the age of one.\u00a0 For the sake of your own human body, as well as those of loved ones, you should be aware of choking risks, signs, and treatments.<\/p>\n<p>Choking is the mechanical obstruction of the flow of air from the atmosphere into the lungs. It prevents breathing, and may be partial or complete. Partial choking allows some \u2014 though inadequate \u2014 air flow into the lungs. Prolonged or complete choking results in asphyxia, or suffocation, which is potentially fatal.<\/p>\n<p>Obstruction of the airway typically occurs in the pharynx or trachea. Young children are more prone to choking than are older people, in part because they often put small objects in their mouth and do not understand the risk of choking that they pose. Young children may choke on small toys or parts of toys, or on household objects, in addition to food. Foods that are round (hotdogs, carrots, grapes) or can adapt their shape to that of the pharynx (bananas, marshmallows), are especially dangerous, and may cause choking in adults, as well as children.<\/p>\n<p>How can you tell if a loved one is choking? The person cannot speak or cry out, or has great difficulty doing so. Breathing, if possible, is laboured, producing gasping or wheezing. The person may desperately clutch at his or her throat or mouth. If breathing is not soon restored, the person\u2019s face will start to turn blue from lack of oxygen. This will be followed by unconsciousness, brain damage, and possibly death if oxygen deprivation continues beyond a few minutes.<\/p>\n<p>If an infant is choking, turning the baby upside down and slapping him on the back may dislodge the obstructing object. To help an older person who is choking, first encourage the person to cough. Give them a few hard back slaps to help force the lodged object out of the airway. If these steps fail, perform the Heimlich maneuver on the person. See the series of\u00a0 videos below, from ProCPR, which demonstrate several ways to help someone who is choking based on age and consciousness.<\/p>\n<p>&nbsp;<\/p>\n<div>\n<p>https:\/\/www.youtube.com\/watch?v=XOTbjDGZ7wg&amp;t=46s<\/p>\n<p style=\"text-align: center\">Conscious Adult Choking, ProCPR, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=5kmsKNvKAvU<\/p>\n<p style=\"text-align: center\">Unconscious Adult Choking, ProCPR, 2011.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=ZjmbD7aIaf0<\/p>\n<p style=\"text-align: center\">Conscious Child Choking, ProCPR, 2009.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=Sba0T2XGIn4<\/p>\n<p style=\"text-align: center\">Unconscious Child Choking, ProCPR, 2009.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=axqIju9CLKA<\/p>\n<p style=\"text-align: center\">Conscious Infant Choking, ProCPR, 2011.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=_K7Dwy6b2wQ<\/p>\n<p style=\"text-align: center\">Unconscious Infant Choking, ProCPR, 2011.<\/p>\n<\/div>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">13.2 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4286\">Respiration<\/a> is the process in which oxygen moves from the outside air into the body, and in which carbon dioxide and other waste gases move from inside the body into the outside air. It involves two subsidiary processes: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4287\">ventilation<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4288\">gas exchange<\/a>. Respiration is carried out mainly by the respiratory system.<\/li>\n<li>The organs of the respiratory system form a continuous system of passages, called the respiratory tract. It has two major divisions: the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4290\">upper respiratory tract<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4291\">lower respiratory tract<\/a>.<\/li>\n<li>The upper respiratory tract includes the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4295\">nasal cavity<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4296\">pharynx<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4298\">larynx<\/a>. All of these organs are involved in conduction, or the movement of air into and out of the body. Incoming air is also cleaned, humidified, and warmed as it passes through the upper respiratory tract. The larynx is called the voice box, because it contains the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4320\">vocal cords<\/a>, which are needed to produce vocal sounds.<\/li>\n<li>The lower respiratory tract includes the trachea, bronchi and bronchioles, and the lungs. The trachea, bronchi, and bronchioles are involved in\u00a0conduction. Gas exchange takes place only in the lungs, which are the largest organs of the respiratory tract. Lung tissue consists mainly of tiny air sacs called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4311\">alveoli<\/a>, which is where gas exchange takes place between air in the alveoli and the blood in capillaries surrounding them.<\/li>\n<li>The respiratory system protects itself from potentially harmful substances in the air by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4815_4318\">mucociliary escalator<\/a>. This includes mucus-producing cells, which trap particles and pathogens in incoming air. It also includes tiny hair-like cilia that continually move to sweep the mucus and trapped debris away from the lungs and toward the outside of the body.<\/li>\n<li>The level of carbon dioxide in the blood is monitored by cells in the brain. If the level becomes too high, it triggers a faster rate of breathing, which lowers the level to the normal range. The opposite occurs if the level becomes too\u00a0low. The respiratory system exchanges gases with the outside air, but it needs the\u00a0cardiovascular system\u00a0to carry the gases to and from cells throughout the body.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">13.2 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-237\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-237\" class=\"h5p-iframe\" data-content-id=\"237\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"13.2 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What is respiration, as carried out by the respiratory system? Name the two subsidiary processes it involves.<\/li>\n<li>Describe the respiratory tract.<\/li>\n<li>Identify the organs of the upper respiratory tract.\u00a0What are their functions?<\/li>\n<li>List the organs of the lower respiratory tract. Which organs are involved only in conduction?<\/li>\n<li>Where does gas exchange take place?<\/li>\n<li>How does the respiratory system protect itself from potentially harmful substances in the air?<\/li>\n<li>Explain how the rate of breathing is controlled.<\/li>\n<li>Why does the respiratory system need the\u00a0cardiovascular system to help it perform its main function of gas exchange?<\/li>\n<li>Describe two ways in which the body prevents food from entering the lungs.<\/li>\n<li>What is the relationship between respiration and cellular respiration?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">13.2 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=8NUxvJS-_0k<\/p>\n<p style=\"text-align: center\">How do lungs work? - Emma Bryce, TED-Ed, 2014.<\/p>\n<p>https:\/\/www.youtube.com\/watch?time_continue=1&amp;v=6iFPs6JlSzY&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Why Do Men Have Deeper Voices? BrainStuff - HowStuffWorks, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=rjibeBSnpJ0<\/p>\n<p style=\"text-align: center\">Why does your voice change as you get older? - Shaylin A. Schundler, TED-Ed, 2018.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 13.2.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/HYovA7yPPvI\" rel=\"cc:attributionURL\">Exhale by pavel-lozovikov-HYovA7yPPvI<\/a> [photo] by <a href=\"https:\/\/unsplash.com\/photos\/HYovA7yPPvI\">Pavel Lozovikov<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 13.2.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Illu_conducting_passages.svg\" rel=\"cc:attributionURL\">Illu_conducting_passages.svg<\/a> by <a title=\"User:Lord Akryl\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Lord_Akryl\">Lord Akryl<\/a>,\u00a0<a title=\"User:Jmarchn\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Jmarchn\">Jmarchn<\/a> from <a href=\"https:\/\/training.seer.cancer.gov\/\">SEER Training Modules\/ National Cancer Institute<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public<\/a><a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\"> domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 13.2.3<\/strong><\/p>\n<p><a href=\"http:\/\/www.medicalgraphics.de\/en\/free-pictures\/organe\/larynx.html\" rel=\"cc:attributionURL\">Larynx<\/a> by <a href=\"http:\/\/www.medicalgraphics.de\/en\/free-pictures\/organe\/larynx.html\">www.medicalgraphics.de<\/a>\u00a0 is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/\" rel=\"license\">CC BY-ND 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/) license.<\/p>\n<p><strong>Figure 13.2.4<\/strong><\/p>\n<p><a href=\"https:\/\/visuals.nci.nih.gov\/details.cfm?imageid=4370\" rel=\"cc:attributionURL\">Larynx top view<\/a>\u00a0by Alan Hoofring (Illustrator) for <a href=\"https:\/\/visuals.nci.nih.gov\/details.cfm?imageid=4370\">National Cancer Institute<\/a> is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public<\/a><a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\"> domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 13.2.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Lungs_diagram_detailed.svg\" rel=\"cc:attributionURL\">2000px-Lungs_diagram_detailed.svg<\/a> by <a class=\"mw-userlink\" title=\"User:Patrick.lynch\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Patrick.lynch\">Patrick J. Lynch<\/a>, medical illustrator on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\" rel=\"license\">CC BY 2.5<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.5) license.\u00a0(Derivative work of <a title=\"File:Fruchtwasserembolie.png\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Fruchtwasserembolie.png\">Fruchtwasserembolie.png.<\/a>)<\/p>\n<p><strong>Figure 13.2.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2312_Gross_Anatomy_of_the_Lungs.jpg\" rel=\"cc:attributionURL\">Gross_Anatomy_of_the_Lungs<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/22-2-the-lungs\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 13.2.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Figure_39_01_09.jpg\" rel=\"cc:attributionURL\">Alveoli Structure<\/a>\u00a0by <a href=\"https:\/\/cnx.org\/contents\/GFy_h8cu@10.53:35-R0biq@11\/Systems-of-Gas-Exchange\">CNX OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0) license.<\/p>\n<p><strong>Figure 13.2.8<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:An_annotated_diagram_of_an_alveolus.svg\" rel=\"cc:attributionURL\">annotated_diagram_of_an_alveolus.svg<\/a> by <a class=\"new\" title=\"User:Katherinebutler1331 (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Katherinebutler1331&amp;action=edit&amp;redlink=1\">Katherinebutler1331<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 13.2.9<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Sneeze.JPG\" rel=\"cc:attributionURL\">Sneeze<\/a> by James Gathany at <a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=11162\">CDC Public Health Imagery Library (PHIL) #11162<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public<\/a><a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\"> domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). <\/span>Figure 22.2 Major respiratory structures <span id=\"4572\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight first text last focus\" data-timestamp=\"1596823737203\" data-highlight-id=\"56d673ee-04fc-4187-a8ca-ee010b205bee\" data-highlighted=\"true\">[digital image].\u00a0 In<em> Anatomy and Physiology<\/em> (Section 22.1). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/22-1-organs-and-structures-of-the-respiratory-system [CC BY 4.0 (https:\/\/creativecommons.org\/licenses\/by\/4.0)].<\/span><\/span><\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure <\/span><span class=\"os-number\">22.13<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"4572\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight first text last focus\" data-timestamp=\"1596823737203\" data-highlight-id=\"56d673ee-04fc-4187-a8ca-ee010b205bee\" data-highlighted=\"true\">Gross anatomy of the lungs [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 22.2). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/22-2-the-lungs<\/span><\/span><\/p>\n<p class=\"hanging-indent\">BrainStuff - HowStuffWorks. (2015, December 1). Why do men have deeper voices?\u00a0 YouTube. https:\/\/www.youtube.com\/watch?v=6iFPs6JlSzY&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Dr. Lotz. (2018, January 25). Larynx model - Respiratory system. YouTube. https:\/\/www.youtube.com\/watch?v=BsyB88mq5rQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">I-Hsun Wu. (<span style=\"font-size: 1em\">2015, March 31). <\/span>Mucociliary clearance. <span style=\"font-size: 1em\">YouTube. https:\/\/www.youtube.com\/watch?v=HMB6flEaZwI&amp;feature=youtu.be<\/span><\/p>\n<p class=\"hanging-indent\">OpenStax. (<span style=\"text-align: initial;font-size: 1em\">2016, May 27). <\/span>Figure 9 Terminal bronchioles are connected by respiratory bronchioles to alveolar ducts and alveolar sacs [digital image]. In <span style=\"font-size: 1em\"><em>OpenStax, Biology<\/em> (Section 39.1).<\/span><span style=\"font-size: 1em\">\u00a0<\/span><span style=\"text-align: initial;font-size: 1em\">OpenStax CNX. \u00a0https:\/\/cnx.org\/contents\/GFy_h8cu@10.53:35-R0biq@11\/Systems-of-Gas-Exchange<\/span><\/p>\n<p class=\"hanging-indent\">ProCPR. (2009, November 24). Conscious child choking. YouTube. https:\/\/www.youtube.com\/watch?v=ZjmbD7aIaf0&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">ProCPR. (2009, November 24).Unconscious child choking. YouTube. https:\/\/www.youtube.com\/watch?v=Sba0T2XGIn4&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">ProCPR. (2011, February 1). Conscious infant choking. YouTube. https:\/\/www.youtube.com\/watch?v=axqIju9CLKA&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">ProCPR. (2011, February 1). Unconscious adult choking. YouTube. https:\/\/www.youtube.com\/watch?v=5kmsKNvKAvU&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">ProCPR. (2011, February 1). Unconscious infant choking. YouTube. https:\/\/www.youtube.com\/watch?v=_K7Dwy6b2wQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">ProCPR. (2016, April 8). Conscious adult choking. YouTube. https:\/\/www.youtube.com\/watch?v=XOTbjDGZ7wg&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2014, November 24). How do lungs work? - Emma Bryce. YouTube. https:\/\/www.youtube.com\/watch?v=8NUxvJS-_0k&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2018, August 2). Why does your voice change as you get older? - Shaylin A. Schundler. YouTube. https:\/\/www.youtube.com\/watch?v=rjibeBSnpJ0&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5875\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5875\"><div tabindex=\"-1\"><p>A non-steroid catecholamine hormone produced by the medulla of the adrenal glands that stimulates the fight-or-flight response.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_6013\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_6013\"><div tabindex=\"-1\"><p>An involuntary human body response mediated by the nervous and endocrine systems that prepares the body to fight or flee from perceived danger.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5881\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5881\"><div tabindex=\"-1\"><p>The main mineralocorticoid hormone which is responsible for sodium conservation in the kidney, salivary glands, sweat glands and colon.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5959\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5959\"><div tabindex=\"-1\"><p>A glucocorticoid hormone produced by the cortex of the adrenal gland that is released in response to stress and also helps control metabolic rate, suppression of the immune system, and other functions<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3408\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3408\"><div tabindex=\"-1\"><p>A type of disease in which cells of the central nervous system stop working or die. Neurodegenerative disorders usually get worse over time and have no cure. They may be genetic or be caused by a tumor or stroke.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3409\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3409\"><div tabindex=\"-1\"><p>A substance that takes part in and undergoes change during a chemical reaction.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_5995\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_5995\"><div tabindex=\"-1\"><p>The female sex hormone secreted mainly by the ovaries.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3411\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3411\"><div tabindex=\"-1\"><p>A substance that is formed as the result of a chemical reaction.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3412\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3412\"><div tabindex=\"-1\"><p>A substance that is formed as the result of a chemical reaction.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3413\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3413\"><div tabindex=\"-1\"><p>A lasting attraction between atoms, ions or molecules that enables the formation of chemical compounds.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3414\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3414\"><div tabindex=\"-1\"><p>A lasting attraction between atoms, ions or molecules that enables the formation of chemical compounds.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_1984\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_1984\"><div tabindex=\"-1\"><p>inflammation of the epididymis, which may be acute or chronic<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3415\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3415\"><div tabindex=\"-1\"><p>An expression that gives the identities and quantities of the substances involved in a reaction. A chemical equation shows the starting compound(s)\u2014the reactants\u2014on the left and the final compound(s)\u2014the products\u2014on the right, separated by an arrow.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4815_3417\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4815_3417\"><div tabindex=\"-1\"><p>The law of conservation of mass states that mass can neither be created nor destroyed in a chemical reaction. Thus, the amount of matter cannot change.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"author":32,"menu_order":2,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":"cc-by-nc"},"chapter-type":[48],"contributor":[],"license":[55],"class_list":["post-4815","chapter","type-chapter","status-publish","hentry","chapter-type-numberless","license-cc-by-nc"],"part":4807,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/users\/32"}],"version-history":[{"count":4,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4815\/revisions"}],"predecessor-version":[{"id":6444,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4815\/revisions\/6444"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/parts\/4807"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4815\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/media?parent=4815"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapter-type?post=4815"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/contributor?post=4815"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/license?post=4815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}