{"id":4794,"date":"2019-06-24T14:53:08","date_gmt":"2019-06-24T14:53:08","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/10-7-human-senses-3\/"},"modified":"2023-11-30T18:51:22","modified_gmt":"2023-11-30T18:51:22","slug":"10-7-human-senses-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/10-7-human-senses-3\/","title":{"raw":"8.7\u00a0Human Senses","rendered":"8.7\u00a0Human Senses"},"content":{"raw":"&nbsp;\r\n\r\n[caption id=\"attachment_3120\" align=\"aligncenter\" width=\"700\"]<img class=\"wp-image-3120 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Bee-Stereogram-2.jpg\" alt=\"\" width=\"700\" height=\"500\" \/> <em>Figure 8.7.1 This stereogram contains a hidden image, BEE-lieve it or not.<\/em>[\/caption]\r\n\r\n<span style=\"font-size: 1.602em; font-weight: bold;\">Seeing Is Believing<\/span>\r\n\r\nAt first glance, Figure 8.7.1 appears to be just random dots of colour, but hidden within it is the three-dimensional shape of a bee. Can you see it among the dots? This figure is an example of a [pb_glossary id=\"3121\"]stereogram[\/pb_glossary], which is a two-dimensional picture that, when viewed correctly, reveals a three-dimensional object. If you can\u2019t see the hidden image, it doesn\u2019t mean that there is anything wrong with your eyes. It\u2019s all in how your brain interprets what your eyes are sensing. The eyes are special sensory organs, and vision is one of our special senses.\r\n<div>\r\n<h1>Special and\u00a0General Senses<\/h1>\r\n<\/div>\r\nThe\u00a0human body\u00a0has two basic types of senses, called special senses and general senses.\u00a0<strong>[pb_glossary id=\"3122\"]Special senses[\/pb_glossary]<\/strong>\u00a0have specialized sense organs that gather sensory information and change it into\u00a0nerve impulses. Special senses include vision (for which the\u00a0eyes\u00a0are the specialized sense organs), hearing (ears), balance (ears), taste (tongue), and smell (nasal passages).\u00a0<strong>[pb_glossary id=\"3123\"]General senses[\/pb_glossary],<\/strong>\u00a0in contrast, are all associated with the sense of touch. They lack special sense organs. Instead, sensory information about touch is gathered by the skin and other\u00a0body tissues, all of which have important functions besides gathering sense information. Whether the senses are special or general, however,\u00a0they all\u00a0depend on\u00a0cells called sensory receptors.\r\n<div>\r\n<h1>Sensory Receptors<\/h1>\r\n<\/div>\r\nA\u00a0<strong>[pb_glossary id=\"3006\"]sensory receptor[\/pb_glossary]<\/strong>\u00a0is a specialized nerve cell that responds to a stimulus in the internal or external environment by generating a\u00a0nerve impulse. The nerve impulse then travels along the sensory (afferent) nerve to the\u00a0central nervous system\u00a0for processing and to form a response.\r\n\r\nThere are several different types of sensory receptors that respond to different kinds of stimuli:\r\n<ul>\r\n \t<li><strong>[pb_glossary id=\"3124\"]Mechanoreceptors[\/pb_glossary]<\/strong>\u00a0respond to mechanical forces, such as pressure, roughness, vibration, and stretching. Most mechanoreceptors are found in the skin and are needed for the sense of touch. Mechanoreceptors are also found in the inner ear, where they are needed for the senses of\u00a0hearing and balance.<\/li>\r\n \t<li><strong>[pb_glossary id=\"3125\"]Thermoreceptors[\/pb_glossary]<\/strong>\u00a0respond to variations in\u00a0temperature. They are found mostly in the skin and detect temperatures that are above or below body temperature.<\/li>\r\n \t<li><strong>[pb_glossary id=\"3126\"]Nociceptors[\/pb_glossary]<\/strong>\u00a0respond to potentially damaging stimuli, which are generally perceived as pain. They are found in internal organs, as well as on the surface of the body. Different nociceptors are activated depending on the particular stimulus.\u00a0Some detect damaging\u00a0heat\u00a0or cold, others detect excessive pressure, and still others detect painful chemicals (such as very hot spices in food).<\/li>\r\n \t<li><strong>[pb_glossary id=\"3127\"]Photoreceptors[\/pb_glossary]<\/strong>\u00a0detect and respond to light. Most photoreceptors are found in the\u00a0eyes\u00a0and are needed for the sense of vision.<\/li>\r\n \t<li><strong>[pb_glossary id=\"3128\"]Chemoreceptors[\/pb_glossary]<\/strong>\u00a0respond to certain chemicals. They are found mainly in taste buds on the tongue \u2014 where they are needed for the sense of taste \u2014 and in nasal passages, where they are needed for the sense of smell.<\/li>\r\n<\/ul>\r\n<div>\r\n<h1>Touch<\/h1>\r\n<\/div>\r\n<strong>[pb_glossary id=\"3129\"]Touch[\/pb_glossary]<\/strong> is the ability to sense pressure, vibration, temperature, pain, and other tactile stimuli. These types of stimuli are detected by mechanoreceptors, thermoreceptors, and nociceptors all over the body, most noticeably in the skin. These receptors are especially concentrated on the tongue, lips, face, palms of the hands, and soles of the feet. Various types of tactile receptors in the skin are shown in Figure 8.7.2.\r\n\r\n[caption id=\"attachment_3130\" align=\"aligncenter\" width=\"787\"]<img class=\"wp-image-3130\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Skin_TactileReceptors-2.png\" alt=\"\" width=\"787\" height=\"787\" \/> <em>Figure 8.7.2 Tactile receptors in the skin include free nerve endings, Merkel cells, Meissner\u2019s corpuscles, Pacinian corpuscles, root hair plexuses, and Ruffini corpuscles. Each type of sensory receptor responds to a different kind of tactile stimulus. For example, free nerve endings generally respond to pain and temperature variations, whereas Merkel cells are associated with the sense of light touch and the discrimination of shapes and textures.<\/em>[\/caption]\r\n\r\n<div>\r\n\r\n[caption id=\"attachment_3131\" align=\"alignright\" width=\"216\"]<img class=\"wp-image-3131\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Eye-by-Victor-Freitas-on-Unsplash-scaled-3.jpg\" alt=\"\" width=\"216\" height=\"144\" \/> <em>Figure 8.7.3 The human eye is a sensory organ that collects and focusses light, forms images,\u00a0and changes them to nerve impulses.<\/em>[\/caption]\r\n\r\n<span style=\"font-size: 1.602em; font-weight: bold;\">Vision<\/span>\r\n\r\n<\/div>\r\n<strong>Vision<\/strong>\u00a0(or sight) is the ability to sense light and see. The\u00a0<strong>eye<\/strong> is the special sensory organ that collects and focuses light and forms images. The eye, however, is not sufficient for us to see. The brain also plays a necessary role in vision.\u00a0 Vision is our primary sense and more than 50 per cent of the cerebral cortex is devoted to processing visual information.\u00a0 A person with normal colour vision can differentiate between hundreds of thousands of different colours, hues, and shades.\r\n<h2>How the Eye Works<\/h2>\r\nFigure 8.7.4 (below) shows the anatomy of the human eye in cross-section. The eye gathers and focuses light to form an image, and then changes the image to nerve impulses that travel to the brain. The eye's functions are summarized in the following steps.\r\n<ol>\r\n \t<li>Light passes first through the\u00a0<strong>[pb_glossary id=\"5953\"]cornea[\/pb_glossary]<\/strong>, which is a clear outer layer that protects the eye and helps to focus the light by refracting (or bending) it.<\/li>\r\n \t<li>Next, light enters the interior of the eye through an opening called the\u00a0<strong>[pb_glossary id=\"3134\"]pupil[\/pb_glossary]<\/strong>. The size of this opening is controlled by the coloured part of the eye (called the <strong>[pb_glossary id=\"3135\"]iris[\/pb_glossary]<\/strong>), which adjusts the size based on the brightness of the light. The iris causes the pupil to narrow in bright light and widen in dim light.\u00a0 Filling the space between the cornea and the iris is a semi-gelatinous fluid called [pb_glossary id=\"5895\"]aqueous humor[\/pb_glossary] and functions to maintain the shape of the eye.<\/li>\r\n \t<li>The light then passes through the\u00a0<strong>[pb_glossary id=\"3137\"]lens[\/pb_glossary]<\/strong>, which refracts the light even more and focuses it on the retina at the back of the eye, as an inverted image. Sitting behind the lens is a gelatinous fluid called [pb_glossary id=\"3138\"]vitreous humor[\/pb_glossary], which functions to maintain the shape of the eye.<\/li>\r\n \t<li>The\u00a0<strong>[pb_glossary id=\"3139\"]retina[\/pb_glossary]<\/strong> contains two types of photoreceptors: rod and cone cells . <strong>[pb_glossary id=\"3140\"]Rod cells[\/pb_glossary]<\/strong>, which are found mainly in all areas of the retina other than the very center, are particularly sensitive to low levels of light.\u00a0<strong>[pb_glossary id=\"3141\"]Cone cells[\/pb_glossary]<\/strong>, which are found mainly in the center of the retina, are sensitive to light of different colours, and allow colour vision. The rods and cones convert the light that strikes them to nerve impulses.<\/li>\r\n \t<li>The nerve impulses from the rods and cones travel to the optic nerve via the\u00a0<strong>[pb_glossary id=\"3142\"]optic disc[\/pb_glossary] <\/strong>(also known as the optic nerve), which is a circular area at the back of the eye where the optic nerve connects to the retina.<\/li>\r\n<\/ol>\r\n[caption id=\"attachment_3132\" align=\"alignnone\" width=\"675\"]<img class=\" wp-image-3132\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/EyeAnatomy_01-2.png\" alt=\"Diagram of the Eye\" width=\"675\" height=\"506\" \/> <em>Figure 8.7.4 Trace the path of light through the eye as you read about in the five steps above.<\/em>[\/caption]\r\n<h2>Colour Vision<\/h2>\r\nHumans have colour vision because we have three types of cone cells:\u00a0 blue, green and red.\u00a0 Each of these types of cone cell detects a specific wavelength of light, for which they are named.\u00a0 The combined stimulus\u00a0 is then perceived as a specific colour, based on the ratio of the amount stimulus coming from each of the three types of cone cells.\u00a0 Do you know what else uses these same three pieces of information to communicate colour?\u00a0 Your computer monitor!\u00a0 When working in a creative program, such as Paint, these three reference points of red (R), green (G), and blue (B), can be used to create any of the million colours the human eye can perceive, as illustrated in Figure 8.7.5. Take a look at each of the numerical values for red, green, and blue and what colour their combined values create:\r\n\r\n[h5p id=\"565\"]\r\n\r\n<em>Figure 8.7.5 RGB colours.\u00a0<\/em>\r\n<h2>Role of the Brain in Vision<\/h2>\r\nThe optic nerves from both eyes meet and cross just below the bottom of the [pb_glossary id=\"2937\"]hypothalamus[\/pb_glossary] in the brain. The information from both eyes is sent to the visual cortex in the [pb_glossary id=\"3090\"]occipital lobe[\/pb_glossary] of the [pb_glossary id=\"5941\"]cerebrum[\/pb_glossary], which is part of the [pb_glossary id=\"5937\"]cerebral cortex[\/pb_glossary]. The visual cortex is the largest system in the human brain, and is responsible for processing visual images. It interprets messages from both eyes and \u201ctells\u201d us what we are seeing.\r\n<h2>Vision Problems<\/h2>\r\n[caption id=\"attachment_3146\" align=\"alignright\" width=\"279\"]<img class=\" wp-image-3146\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Glasses-by-dmitry-ratushny-wpi3sDUrSEk-unsplash-scaled-3.jpg\" alt=\"Vision Problems\" width=\"279\" height=\"185\" \/> <em>Figure 8.7.6 The three vision problems described are typically solved by using glasses.<\/em>[\/caption]\r\n\r\nVision problems are very common. Two of the most common are [pb_glossary id=\"3144\"]myopia[\/pb_glossary] and [pb_glossary id=\"3145\"]hyperopia[\/pb_glossary], and they often start in\u00a0childhood\u00a0or adolescence. Another common problem, called presbyopia, occurs in most people, beginning\u00a0in middle\u00a0adulthood. In all three conditions, the eyes fail to focus images correctly on the retina, resulting in blurred vision.\r\n<h3>Myopia<\/h3>\r\n[caption id=\"attachment_3147\" align=\"alignleft\" width=\"398\"]<img class=\"wp-image-3147 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Myopia_Diagram-2.jpg\" alt=\"Myopia Diagram\" width=\"398\" height=\"307\" \/> <em>Figure 8.7.7 In a patient who is nearsighted, the image is focused in front of the retina, resulting in distant objects appearing out of focus.<\/em>[\/caption]\r\n\r\n[pb_glossary id=\"3144\"]<strong>Myopia<\/strong>[\/pb_glossary] (or nearsightedness) occurs when the light that comes into the eye does not directly focus\u00a0<em>on<\/em>\u00a0the retina, but\u00a0<em>in front<\/em> of it, as shown in Figure 8.7.7. As a result, distant objects may appear out of focus, but the focus of close objects is not affected. Myopia may occur because the eyeball is elongated from front to back, or because the cornea is too curved. Myopia can be corrected with the use of corrective lenses, either eyeglasses or contact lenses. Myopia can also be corrected by refractive surgery performed with a laser.\r\n<h3>Hyperopia<\/h3>\r\n[caption id=\"attachment_3148\" align=\"alignright\" width=\"400\"]<img class=\"size-full wp-image-3148\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Hyperopia-2.gif\" alt=\"Hyperopia\" width=\"400\" height=\"308\" \/> <em>Figure 8.7.8 In a patient who exhibits hyperopia, the image focuses at a point somewhere behind the retina, causing close objects to appear blurry.<\/em>[\/caption]\r\n\r\n<strong>Hyperopia<\/strong>\u00a0(or farsightedness)\u00a0happens\u00a0when the light\u00a0coming\u00a0into the eye does not directly focus\u00a0<em>on<\/em>\u00a0the retina but\u00a0<em>behind<\/em> it, as shown in Figure 8.7.8. This causes close objects to appear out of focus, but does not affect the focus of distant objects. Hyperopia may occur because the eyeball is too short from front to back, or because the lens is not curved enough. Hyperopia can be corrected through the use of corrective lenses or laser surgery.\r\n<div><\/div>\r\n<h3>Presbyopia<\/h3>\r\n<strong>Presbyopia<\/strong> is a vision problem associated with aging, in which the eye gradually loses its ability to focus on close objects. The precise\u00a0origin\u00a0of presbyopia is not known for certain, but evidence suggests that the lens may become less elastic with age, causing the\u00a0muscles\u00a0that control the lens\u00a0to\u00a0lose power as people grow older. The first signs of presbyopia \u2014 eyestrain, difficulty seeing in dim light, problems focusing on small objects and fine print \u2014 are usually first noticed between the ages of 40 and 50. Most older people with this problem use corrective lenses to focus on close objects, because surgical procedures to correct presbyopia have not been as successful as those for myopia and hyperopia.\r\n<div>\r\n<h1>Hearing<\/h1>\r\n<\/div>\r\n<strong>[pb_glossary id=\"3151\"]Hearing[\/pb_glossary]<\/strong>\u00a0is the ability to sense\u00a0sound waves, and the\u00a0<strong>[pb_glossary id=\"5977\"]ear[\/pb_glossary]<\/strong> is the organ that senses sound. Sound waves enter the ear through the ear canal and travel to the eardrum (see the diagram of the ear Figure 8.7.9). The sound waves strike the eardrum, and make it vibrate. The vibrations then travel through the three tiny bones (incus, malleus and stapes) of the middle ear, which amplify the vibrations. From the middle ear, the vibrations pass to the cochlea in the inner ear. The <strong>[pb_glossary id=\"5949\"]cochlea[\/pb_glossary]<\/strong>\u00a0is a coiled tube filled with\u00a0liquid. The liquid moves in response to the vibrations, causing tiny\u00a0hair\u00a0cells(which are [pb_glossary id=\"3124\"]mechanoreceptors[\/pb_glossary]) lining the cochlea to bend. In response, the hair cells send nerve impulses to the auditory nerve, which carries the impulses to the brain. The brain interprets the impulses and \u201ctells\u201d us what we are hearing.\r\n\r\n[caption id=\"attachment_3154\" align=\"aligncenter\" width=\"480\"]<img class=\"size-full wp-image-3154\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/AnatomyHumanEar-2.gif\" alt=\"\" width=\"480\" height=\"344\" \/> <em>Figure 8.7.9 Most of the structures of the ear are involved in hearing. Only the semicircular canals are not involved in hearing. Instead, they sense head position, which is used to monitor balance.<\/em>[\/caption]\r\n\r\n<div>\r\n\r\n&nbsp;\r\n\r\n<span style=\"font-size: 1.602em; font-weight: bold;\">Balance<\/span>\r\n\r\n<\/div>\r\nThe ears are also responsible for the sense of balance.\u00a0<strong>[pb_glossary id=\"3155\"]Balance[\/pb_glossary]<\/strong>\u00a0is the ability to sense and maintain an appropriate body position. The [pb_glossary id=\"3156\"]semicircular canals[\/pb_glossary] inside the ear (see the figure\u00a0above) contain fluid that moves when the head changes position. Tiny hairs lining the semicircular canals sense movement of the fluid. In response, they send nerve impulses to the vestibular nerve, which carries the impulses to the brain. The brain interprets the impulses and sends messages to the\u00a0peripheral nervous system, which triggers contractions of\u00a0skeletal muscles\u00a0as needed to maintain balance.\r\n<div>\r\n<h1>Taste and\u00a0Smell<\/h1>\r\n<\/div>\r\n[pb_glossary id=\"3157\"]<strong>Taste<\/strong>[\/pb_glossary] and [pb_glossary id=\"3158\"]<strong>smell<\/strong>[\/pb_glossary]\u00a0are both abilities to sense chemicals, so both taste and olfactory (odor) receptors are [pb_glossary id=\"3128\"]chemoreceptors[\/pb_glossary]. Both types of chemoreceptors send nerve impulses to the brain along sensory nerves, and the brain \u201ctells\u201d us what we are tasting or smelling.\r\n\r\nTaste receptors are found in tiny bumps on the tongue called\u00a0<strong>[pb_glossary id=\"3159\"]taste buds[\/pb_glossary].<\/strong>You can see a diagram of a taste receptor cell and related structures in Figure 8.7.10. Taste receptor cells make contact with chemicals in food through tiny openings called <strong>[pb_glossary id=\"3160\"]taste pores[\/pb_glossary]<\/strong>. When certain chemicals bind with taste receptor cells, it generates nerve impulses that travel through afferent nerves to the CNS. There are separate taste receptors for sweet, salty, sour, bitter, and meaty tastes. The meaty \u2014 or savory \u2014 taste is called umami.\r\n\r\n[caption id=\"attachment_3161\" align=\"aligncenter\" width=\"532\"]<img class=\" wp-image-3161\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Taste_bud_2_eng.svg_-2.png\" alt=\"\" width=\"532\" height=\"627\" \/> <em>Figure 8.7.10 Taste receptor cells are located in taste buds on the tongue. Basal cells are not involved in tasting, but differentiate into taste receptor cells. Taste receptor cells are replaced about every nine to ten days.<\/em>[\/caption]\r\n\r\n<div>\r\n\r\n[caption id=\"attachment_3162\" align=\"aligncenter\" width=\"518\"]<img class=\" wp-image-3162\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Head_olfactory_nerve-2.jpg\" alt=\"Olfactory Cells\" width=\"518\" height=\"590\" \/> <em>Figure 8.7.11 The yellow structures inside this drawing of the nasal passages are an olfactory nerve with many nerve endings. The nerve endings sense chemicals in the air as it passes through the nasal cavities.<\/em>[\/caption]\r\n\r\n<\/div>\r\n<div>\r\n<h1>Feature: Human Biology in the News<\/h1>\r\n<\/div>\r\nThe most common cause of blindness in the Western hemisphere is\u00a0<strong><a href=\"https:\/\/www.webmd.com\/eye-health\/macular-degeneration\/age-related-macular-degeneration-overview#1\">age-related macular degeneration<\/a> (AMD).<\/strong> Approximately 1.4 million people in Canada have this type of blindness, and 196 million people are affected worldwide and is expected to increase to 288 millions people by the year 2040. At present, there is no cure for AMD. The disease occurs with the death of a layer of cells called retinal pigment epithelium, which normally provides nutrients and other support to the macula of the eye. The macula is an oval-shaped pigmented area near the center of the retina that is specialized for high visual acuity and has the retina\u2019s greatest concentration of cones. When the epithelial cells die and the macula is no longer supported or nourished, the macula also starts to die. Patients experience a black spot in the center of their vision, and as the disease progresses, the black spot grows outward. Patients eventually lose the ability to read and even to recognize familiar faces before developing total blindness.\r\n\r\nIn 2016, a landmark surgery was performed as a trial on a patient with severe AMD. In the first ever operation of its kind, Dr. Pete Coffey of the University of London implanted a tiny patch of cells behind the retina in each of the patient\u2019s eyes. The cells were retinal pigmented epithelial cells that had been grown in a lab from\u00a0<strong>[pb_glossary id=\"3163\"]stem cells[\/pb_glossary],<\/strong>\u00a0which are undifferentiated cells that\u00a0can\u00a0develop into other cell types.\u00a0Within\u00a0six months\u00a0of\u00a0the operation, the new cells were still surviving, and the doctor was hopeful that the patient\u2019s vision loss would stop and even be reversed. At that point, several other operations had already been planned to test the new procedure. If these cases are a success, Dr. Coffey predicts that the surgery will become as routine as cataract surgery, and that it will prevent millions of patients from losing their vision.\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">8.7 Summary<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul>\r\n \t<li>The\u00a0human body\u00a0has two major types of senses: [pb_glossary id=\"3122\"]special senses[\/pb_glossary] and [pb_glossary id=\"3123\"]general senses[\/pb_glossary]. Special senses have specialized sense organs and include [pb_glossary id=\"3164\"]vision[\/pb_glossary] (eyes), [pb_glossary id=\"3151\"]hearing[\/pb_glossary] (ears), [pb_glossary id=\"3155\"]balance[\/pb_glossary] (ears), [pb_glossary id=\"3157\"]taste[\/pb_glossary] (tongue), and [pb_glossary id=\"3158\"]smell[\/pb_glossary] (nasal passages). General senses are all associated with [pb_glossary id=\"3129\"]touch[\/pb_glossary] and lack special sense organs. Touch receptors are found throughout the body, but particularly in the skin.<\/li>\r\n \t<li>All senses depend on sensory receptor cells to detect sensory stimuli and transform them into nerve impulses. Types of sensory receptors include [pb_glossary id=\"3124\"]mechanoreceptors[\/pb_glossary]\u00a0(mechanical forces), [pb_glossary id=\"3125\"]thermoreceptors[\/pb_glossary]\u00a0(temperature), [pb_glossary id=\"3126\"]nociceptors[\/pb_glossary]\u00a0(pain), [pb_glossary id=\"3127\"]photoreceptors[\/pb_glossary]\u00a0(light), and [pb_glossary id=\"3128\"]chemoreceptors[\/pb_glossary]\u00a0(chemicals).<\/li>\r\n \t<li>Touch\u00a0is\u00a0the ability to sense pressure, vibration,\u00a0temperature, pain, and other tactile stimuli. The skin includes several different types of touch receptor cells.<\/li>\r\n \t<li>Vision is the ability to sense light and see. The eye is the special sensory organ that collects and focuses light, forms images, and changes them to nerve impulses. Optic nerves send information from the eyes to the brain, which processes the visual information and \u201ctells\u201d us what we are seeing.<\/li>\r\n \t<li>Common vision problems include [pb_glossary id=\"3144\"]myopia[\/pb_glossary] (nearsightedness), [pb_glossary id=\"3145\"]hyperopia[\/pb_glossary] (farsightedness), and [pb_glossary id=\"3165\"]presbyopia[\/pb_glossary] (age-related decline in close vision). Vision problems can be corrected with lenses (eyeglasses or contacts) or \u2014 in many cases \u2014 with laser surgery.<\/li>\r\n \t<li>Hearing is the ability to sense sound waves, and the ear is the organ that senses sound. It changes sound waves to vibrations that trigger nerve impulses, which travel to the brain through the auditory nerve. The brain processes the information and \u201ctells\u201d us what we are hearing.<\/li>\r\n \t<li>The ear is also the organ responsible for the sense of balance, which is the ability to sense and maintain an appropriate body position. The ears send impulses about head position to the brain, which sends messages to\u00a0skeletal muscles\u00a0via the\u00a0peripheral nervous system. The\u00a0muscles\u00a0respond by contracting to maintain balance.<\/li>\r\n \t<li>Taste and smell\u00a0are both abilities to sense chemicals. Taste receptors in taste buds on the tongue sense chemicals in food,\u00a0while\u00a0olfactory receptors in the nasal passages sense chemicals in the air.\u00a0Sense of smell contributes significantly to sense of taste.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">8.7 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ol>\r\n \t<li style=\"list-style-type: none;\">\r\n<ol>\r\n \t<li>Compare and contrast special senses and general senses.<\/li>\r\n \t<li>What are sensory receptors?<\/li>\r\n \t<li>[h5p id=\"566\"]<\/li>\r\n \t<li>Describe the\u00a0range of tactile stimuli detected in the sense of touch.<\/li>\r\n \t<li>Explain how the eye collects and focuses light to form an image, and how it converts it to nerve impulses.<\/li>\r\n \t<li>Identify two common vision problems,along with\u00a0their causes and their effects on vision.<\/li>\r\n \t<li>[h5p id=\"567\"]<\/li>\r\n \t<li>Explain how structures of the ear collect and amplify sound waves and transform them to nerve impulses.<\/li>\r\n \t<li>What role does the ear play in balance? Which structures of the ear are involved in balance?<\/li>\r\n \t<li>Describe two ways that the body senses chemicals. What are the special sense organs involved in these senses?<\/li>\r\n \t<li>Explain why your skin can detect different types of stimuli, such as pressure and temperature.<\/li>\r\n \t<li>Is sensory information sent to the central nervous system via efferent or afferent nerves?<\/li>\r\n \t<li>Identify a mechanoreceptor used in two different human senses. Describe the type of mechanical stimuli that each detects.<\/li>\r\n \t<li>If a person is blind, but their retina is functioning properly, where do you think the damage might be? Explain your answer.<\/li>\r\n \t<li>When you see colours, what receptor cells are activated? Where are these receptors located? What lobe of the brain is primarily used to process visual information?<\/li>\r\n \t<li>The auditory nerve carries _______________.<\/li>\r\n<\/ol>\r\n<\/li>\r\n<\/ol>\r\n<ol>\r\n \t<li style=\"list-style-type: none;\">\r\n<ol>\r\n \t<li style=\"list-style-type: none;\">\r\n<ol type=\"a\">\r\n \t<li>smell information<\/li>\r\n \t<li>taste information<\/li>\r\n \t<li>balance information<\/li>\r\n \t<li>sound information<\/li>\r\n<\/ol>\r\n<\/li>\r\n<\/ol>\r\n<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">8.7 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?time_continue=4&amp;v=rkRbebvoYqI&amp;feature=emb_logo\r\n<p style=\"text-align: center;\">What color is Tuesday? Exploring synesthesia - Richard E. Cytowic, TED-Ed, 2013.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=UL8YSLhqa5U&amp;feature=emb_logo\r\n<p style=\"text-align: center;\">What Is Vertigo &amp; Why Do We Get It?, Seeker, 2016.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=t3CjTU7TaNA\r\n<p style=\"text-align: center;\">How do animals see in the dark? - Anna St\u00f6ckl, TED-Ed,\u00a0 2016.<\/p>\r\nhttps:\/\/youtu.be\/Y6e_m9iq-4Q\r\n<p style=\"text-align: center;\">What are those floaty things in your eye? - Michael Mauser, TED-Ed, 2014.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n<h2>Attributions<\/h2>\r\n<strong>Figure 8.7.1<\/strong>\r\n\r\n<a href=\"https:\/\/www.flickr.com\/photos\/78717264@N00\/2361310483\/in\/photostream\/\" rel=\"cc:attributionURL\">Bee Stereogram<\/a>\u00a0by\u00a0<a href=\"https:\/\/www.flickr.com\/photos\/78717264@N00\/\" rel=\"dc:creator\">Be Mosaic<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.\r\n\r\n<strong>Figure 8.7.2<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0809_Skin_TactileReceptors.png\" rel=\"cc:attributionURL\">Skin_TactileReceptors<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\r\n\r\n<strong>Figure 8.7.3<\/strong>\r\n\r\n<a href=\"https:\/\/unsplash.com\/photos\/jxQFMN7xzJc\">Macro shot photograph of someone's right eye <\/a>[photo] by <a href=\"https:\/\/unsplash.com\/@whitfieldjordan?utm_source=unsplash&amp;utm_medium=referral&amp;utm_content=creditCopyText\" rel=\"dc:creator\">Jordan Whitfield<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).\r\n\r\n<strong>Figure 8.7.4<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0388_EyeAnatomy_01.png\" rel=\"cc:attributionURL\">EyeAnatomy_01<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\r\n\r\n<strong>Figure 8.7.5<\/strong>\r\n\r\nRGB colours [screenshots] from Microsoft Paint.\r\n\r\n<strong>Figure 8.7.6<\/strong>\r\n\r\n<a href=\"https:\/\/unsplash.com\/photos\/wpi3sDUrSEk\" rel=\"cc:attributionURL\">Through the reading glasses<\/a>\u00a0[photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@ratushny\">Dmitry Ratushny<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).\r\n\r\n<strong>Figure 8.7.7<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Myopia_Diagram.jpg\" rel=\"cc:attributionURL\">Myopia_Diagram<\/a> by <a class=\"owner-name truncate no-outline\" title=\"Go to National Eye Institute's photostream\" href=\"https:\/\/www.flickr.com\/photos\/nationaleyeinstitute\/\" data-track=\"attributionNameClick\">National Eye Institute<\/a>\/ National Institutes of Health on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.\r\n\r\n<strong>Figure 8.7.8<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Hyperopia.gif\" rel=\"cc:attributionURL\">Hyperopia<\/a> by <a href=\"https:\/\/www.nei.nih.gov\/\">National Institute of Health\/NIH<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 8.7.9<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:AnatomyHumanEar.gif\" rel=\"cc:attributionURL\">AnatomyHumanEar<\/a> by unknown author from <a href=\"https:\/\/www.osha.gov\/dts\/osta\/otm\/new_noise\/\">Occupational Safety &amp; Health Administration<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong style=\"text-align: initial; font-size: 1em;\">Figure 8.7.10<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Taste_bud_2_eng.svg\" rel=\"cc:attributionURL\">Taste_bud_2_eng.svg<\/a> by <a class=\"new\" title=\"User:Jonas T\u00f6le (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Jonas_T%C3%B6le&amp;action=edit&amp;redlink=1\">Jonas T\u00f6le<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication license (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en).\r\n\r\n<strong style=\"text-align: initial; font-size: 1em;\">\r\nFigure 8.7.11\r\n<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Head_olfactory_nerve.jpg\" rel=\"cc:attributionURL\">Head_olfactory_nerve<\/a> by <a class=\"mw-userlink\" title=\"User:Patrick.lynch\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Patrick.lynch\">Patrick.lynch<\/a>, medical illustrator on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en\" rel=\"license\">CC BY 2.5<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en) license.\r\n<h2>References<\/h2>\r\n<p class=\"hanging-indent\">Age-Related Macular Degeneration. (n.d.). WebMD. https:\/\/www.webmd.com\/eye-health\/macular-degeneration\/age-related-macular-degeneration-overview#3 (Reviewed by Alan Kozarsky, MD on October 26, 2019)<\/p>\r\n<p class=\"hanging-indent\">Blausen.com Staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\r\n<p class=\"hanging-indent\">da Cruz, L., Fynes, K., Georgiadis, O. et al. (2018, March 19). Phase 1 clinical study of an embryonic stem cell\u2013derived retinal pigment epithelium patch in age-related macular degeneration. <em>Natural Biotechnology, 36<\/em>, 328\u2013337. https:\/\/doi.org\/10.1038\/nbt.4114<\/p>\r\n<p class=\"hanging-indent\">File:Eye Diagram without text.gif. (2018, February 9).\u00a0<i>Wikimedia Commons.<\/i> https:\/\/commons.wikimedia.org\/w\/index.php?title=File:Eye_Diagram_without_text.gif&amp;oldid=286008241 (original image from\u00a0National Eye Institute\u00a0- modified by\u00a0User:Nordelch) [public domain (https:\/\/en.wikipedia.org\/wiki\/Public_domain)]<\/p>\r\n<p class=\"hanging-indent\">Occupational Health and Safety Administration. (n.d.). Figure 7. Anatomy of the human ear [diagram]. In <em>OSHA Technical Manual<\/em> (Section III, Chapter 5 - Noise). United States Department of Labour [online]. https:\/\/www.osha.gov\/dts\/osta\/otm\/new_noise\/<\/p>\r\n<p class=\"hanging-indent\">Seeker. (2016, March 18). What is vertigo &amp; why do we get it? YouTube. https:\/\/www.youtube.com\/watch?v=UL8YSLhqa5U&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2013, June 10). What color is Tuesday? Exploring synesthesia - Richard E. Cytowic. YouTube. https:\/\/www.youtube.com\/watch?v=rkRbebvoYqI&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2014, December 1). What are those floaty things in your eye? - Michael Mauser. YouTube. https:\/\/www.youtube.com\/watch?v=Y6e_m9iq-4Q&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2016, August 25). How do animals see in the dark? - Anna St\u00f6ckl\u200b. YouTube. https:\/\/www.youtube.com\/watch?v=t3CjTU7TaNA&amp;feature=youtu.be<\/p>\r\n&nbsp;","rendered":"<p>&nbsp;<\/p>\n<figure id=\"attachment_3120\" aria-describedby=\"caption-attachment-3120\" style=\"width: 700px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3120 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Bee-Stereogram-2.jpg\" alt=\"\" width=\"700\" height=\"500\" \/><figcaption id=\"caption-attachment-3120\" class=\"wp-caption-text\"><em>Figure 8.7.1 This stereogram contains a hidden image, BEE-lieve it or not.<\/em><\/figcaption><\/figure>\n<p><span style=\"font-size: 1.602em; font-weight: bold;\">Seeing Is Believing<\/span><\/p>\n<p>At first glance, Figure 8.7.1 appears to be just random dots of colour, but hidden within it is the three-dimensional shape of a bee. Can you see it among the dots? This figure is an example of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3121\">stereogram<\/a>, which is a two-dimensional picture that, when viewed correctly, reveals a three-dimensional object. If you can\u2019t see the hidden image, it doesn\u2019t mean that there is anything wrong with your eyes. It\u2019s all in how your brain interprets what your eyes are sensing. The eyes are special sensory organs, and vision is one of our special senses.<\/p>\n<div>\n<h1>Special and\u00a0General Senses<\/h1>\n<\/div>\n<p>The\u00a0human body\u00a0has two basic types of senses, called special senses and general senses.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3122\">Special senses<\/a><\/strong>\u00a0have specialized sense organs that gather sensory information and change it into\u00a0nerve impulses. Special senses include vision (for which the\u00a0eyes\u00a0are the specialized sense organs), hearing (ears), balance (ears), taste (tongue), and smell (nasal passages).\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3123\">General senses<\/a>,<\/strong>\u00a0in contrast, are all associated with the sense of touch. They lack special sense organs. Instead, sensory information about touch is gathered by the skin and other\u00a0body tissues, all of which have important functions besides gathering sense information. Whether the senses are special or general, however,\u00a0they all\u00a0depend on\u00a0cells called sensory receptors.<\/p>\n<div>\n<h1>Sensory Receptors<\/h1>\n<\/div>\n<p>A\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3006\">sensory receptor<\/a><\/strong>\u00a0is a specialized nerve cell that responds to a stimulus in the internal or external environment by generating a\u00a0nerve impulse. The nerve impulse then travels along the sensory (afferent) nerve to the\u00a0central nervous system\u00a0for processing and to form a response.<\/p>\n<p>There are several different types of sensory receptors that respond to different kinds of stimuli:<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3124\">Mechanoreceptors<\/a><\/strong>\u00a0respond to mechanical forces, such as pressure, roughness, vibration, and stretching. Most mechanoreceptors are found in the skin and are needed for the sense of touch. Mechanoreceptors are also found in the inner ear, where they are needed for the senses of\u00a0hearing and balance.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3125\">Thermoreceptors<\/a><\/strong>\u00a0respond to variations in\u00a0temperature. They are found mostly in the skin and detect temperatures that are above or below body temperature.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3126\">Nociceptors<\/a><\/strong>\u00a0respond to potentially damaging stimuli, which are generally perceived as pain. They are found in internal organs, as well as on the surface of the body. Different nociceptors are activated depending on the particular stimulus.\u00a0Some detect damaging\u00a0heat\u00a0or cold, others detect excessive pressure, and still others detect painful chemicals (such as very hot spices in food).<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3127\">Photoreceptors<\/a><\/strong>\u00a0detect and respond to light. Most photoreceptors are found in the\u00a0eyes\u00a0and are needed for the sense of vision.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3128\">Chemoreceptors<\/a><\/strong>\u00a0respond to certain chemicals. They are found mainly in taste buds on the tongue \u2014 where they are needed for the sense of taste \u2014 and in nasal passages, where they are needed for the sense of smell.<\/li>\n<\/ul>\n<div>\n<h1>Touch<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3129\">Touch<\/a><\/strong> is the ability to sense pressure, vibration, temperature, pain, and other tactile stimuli. These types of stimuli are detected by mechanoreceptors, thermoreceptors, and nociceptors all over the body, most noticeably in the skin. These receptors are especially concentrated on the tongue, lips, face, palms of the hands, and soles of the feet. Various types of tactile receptors in the skin are shown in Figure 8.7.2.<\/p>\n<figure id=\"attachment_3130\" aria-describedby=\"caption-attachment-3130\" style=\"width: 787px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3130\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Skin_TactileReceptors-2.png\" alt=\"\" width=\"787\" height=\"787\" \/><figcaption id=\"caption-attachment-3130\" class=\"wp-caption-text\"><em>Figure 8.7.2 Tactile receptors in the skin include free nerve endings, Merkel cells, Meissner\u2019s corpuscles, Pacinian corpuscles, root hair plexuses, and Ruffini corpuscles. Each type of sensory receptor responds to a different kind of tactile stimulus. For example, free nerve endings generally respond to pain and temperature variations, whereas Merkel cells are associated with the sense of light touch and the discrimination of shapes and textures.<\/em><\/figcaption><\/figure>\n<div>\n<figure id=\"attachment_3131\" aria-describedby=\"caption-attachment-3131\" style=\"width: 216px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3131\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Eye-by-Victor-Freitas-on-Unsplash-scaled-3.jpg\" alt=\"\" width=\"216\" height=\"144\" \/><figcaption id=\"caption-attachment-3131\" class=\"wp-caption-text\"><em>Figure 8.7.3 The human eye is a sensory organ that collects and focusses light, forms images,\u00a0and changes them to nerve impulses.<\/em><\/figcaption><\/figure>\n<p><span style=\"font-size: 1.602em; font-weight: bold;\">Vision<\/span><\/p>\n<\/div>\n<p><strong>Vision<\/strong>\u00a0(or sight) is the ability to sense light and see. The\u00a0<strong>eye<\/strong> is the special sensory organ that collects and focuses light and forms images. The eye, however, is not sufficient for us to see. The brain also plays a necessary role in vision.\u00a0 Vision is our primary sense and more than 50 per cent of the cerebral cortex is devoted to processing visual information.\u00a0 A person with normal colour vision can differentiate between hundreds of thousands of different colours, hues, and shades.<\/p>\n<h2>How the Eye Works<\/h2>\n<p>Figure 8.7.4 (below) shows the anatomy of the human eye in cross-section. The eye gathers and focuses light to form an image, and then changes the image to nerve impulses that travel to the brain. The eye&#8217;s functions are summarized in the following steps.<\/p>\n<ol>\n<li>Light passes first through the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_5953\">cornea<\/a><\/strong>, which is a clear outer layer that protects the eye and helps to focus the light by refracting (or bending) it.<\/li>\n<li>Next, light enters the interior of the eye through an opening called the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3134\">pupil<\/a><\/strong>. The size of this opening is controlled by the coloured part of the eye (called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3135\">iris<\/a><\/strong>), which adjusts the size based on the brightness of the light. The iris causes the pupil to narrow in bright light and widen in dim light.\u00a0 Filling the space between the cornea and the iris is a semi-gelatinous fluid called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_5895\">aqueous humor<\/a> and functions to maintain the shape of the eye.<\/li>\n<li>The light then passes through the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3137\">lens<\/a><\/strong>, which refracts the light even more and focuses it on the retina at the back of the eye, as an inverted image. Sitting behind the lens is a gelatinous fluid called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3138\">vitreous humor<\/a>, which functions to maintain the shape of the eye.<\/li>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3139\">retina<\/a><\/strong> contains two types of photoreceptors: rod and cone cells . <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3140\">Rod cells<\/a><\/strong>, which are found mainly in all areas of the retina other than the very center, are particularly sensitive to low levels of light.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3141\">Cone cells<\/a><\/strong>, which are found mainly in the center of the retina, are sensitive to light of different colours, and allow colour vision. The rods and cones convert the light that strikes them to nerve impulses.<\/li>\n<li>The nerve impulses from the rods and cones travel to the optic nerve via the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3142\">optic disc<\/a> <\/strong>(also known as the optic nerve), which is a circular area at the back of the eye where the optic nerve connects to the retina.<\/li>\n<\/ol>\n<figure id=\"attachment_3132\" aria-describedby=\"caption-attachment-3132\" style=\"width: 675px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3132\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/EyeAnatomy_01-2.png\" alt=\"Diagram of the Eye\" width=\"675\" height=\"506\" \/><figcaption id=\"caption-attachment-3132\" class=\"wp-caption-text\"><em>Figure 8.7.4 Trace the path of light through the eye as you read about in the five steps above.<\/em><\/figcaption><\/figure>\n<h2>Colour Vision<\/h2>\n<p>Humans have colour vision because we have three types of cone cells:\u00a0 blue, green and red.\u00a0 Each of these types of cone cell detects a specific wavelength of light, for which they are named.\u00a0 The combined stimulus\u00a0 is then perceived as a specific colour, based on the ratio of the amount stimulus coming from each of the three types of cone cells.\u00a0 Do you know what else uses these same three pieces of information to communicate colour?\u00a0 Your computer monitor!\u00a0 When working in a creative program, such as Paint, these three reference points of red (R), green (G), and blue (B), can be used to create any of the million colours the human eye can perceive, as illustrated in Figure 8.7.5. Take a look at each of the numerical values for red, green, and blue and what colour their combined values create:<\/p>\n<div id=\"h5p-565\">\n<div class=\"h5p-content\" data-content-id=\"565\"><\/div>\n<\/div>\n<p><em>Figure 8.7.5 RGB colours.\u00a0<\/em><\/p>\n<h2>Role of the Brain in Vision<\/h2>\n<p>The optic nerves from both eyes meet and cross just below the bottom of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2937\">hypothalamus<\/a> in the brain. The information from both eyes is sent to the visual cortex in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3090\">occipital lobe<\/a> of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_5941\">cerebrum<\/a>, which is part of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_5937\">cerebral cortex<\/a>. The visual cortex is the largest system in the human brain, and is responsible for processing visual images. It interprets messages from both eyes and \u201ctells\u201d us what we are seeing.<\/p>\n<h2>Vision Problems<\/h2>\n<figure id=\"attachment_3146\" aria-describedby=\"caption-attachment-3146\" style=\"width: 279px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3146\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Glasses-by-dmitry-ratushny-wpi3sDUrSEk-unsplash-scaled-3.jpg\" alt=\"Vision Problems\" width=\"279\" height=\"185\" \/><figcaption id=\"caption-attachment-3146\" class=\"wp-caption-text\"><em>Figure 8.7.6 The three vision problems described are typically solved by using glasses.<\/em><\/figcaption><\/figure>\n<p>Vision problems are very common. Two of the most common are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3144\">myopia<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3145\">hyperopia<\/a>, and they often start in\u00a0childhood\u00a0or adolescence. Another common problem, called presbyopia, occurs in most people, beginning\u00a0in middle\u00a0adulthood. In all three conditions, the eyes fail to focus images correctly on the retina, resulting in blurred vision.<\/p>\n<h3>Myopia<\/h3>\n<figure id=\"attachment_3147\" aria-describedby=\"caption-attachment-3147\" style=\"width: 398px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3147 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Myopia_Diagram-2.jpg\" alt=\"Myopia Diagram\" width=\"398\" height=\"307\" \/><figcaption id=\"caption-attachment-3147\" class=\"wp-caption-text\"><em>Figure 8.7.7 In a patient who is nearsighted, the image is focused in front of the retina, resulting in distant objects appearing out of focus.<\/em><\/figcaption><\/figure>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3144\"><strong>Myopia<\/strong><\/a> (or nearsightedness) occurs when the light that comes into the eye does not directly focus\u00a0<em>on<\/em>\u00a0the retina, but\u00a0<em>in front<\/em> of it, as shown in Figure 8.7.7. As a result, distant objects may appear out of focus, but the focus of close objects is not affected. Myopia may occur because the eyeball is elongated from front to back, or because the cornea is too curved. Myopia can be corrected with the use of corrective lenses, either eyeglasses or contact lenses. Myopia can also be corrected by refractive surgery performed with a laser.<\/p>\n<h3>Hyperopia<\/h3>\n<figure id=\"attachment_3148\" aria-describedby=\"caption-attachment-3148\" style=\"width: 400px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3148\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Hyperopia-2.gif\" alt=\"Hyperopia\" width=\"400\" height=\"308\" \/><figcaption id=\"caption-attachment-3148\" class=\"wp-caption-text\"><em>Figure 8.7.8 In a patient who exhibits hyperopia, the image focuses at a point somewhere behind the retina, causing close objects to appear blurry.<\/em><\/figcaption><\/figure>\n<p><strong>Hyperopia<\/strong>\u00a0(or farsightedness)\u00a0happens\u00a0when the light\u00a0coming\u00a0into the eye does not directly focus\u00a0<em>on<\/em>\u00a0the retina but\u00a0<em>behind<\/em> it, as shown in Figure 8.7.8. This causes close objects to appear out of focus, but does not affect the focus of distant objects. Hyperopia may occur because the eyeball is too short from front to back, or because the lens is not curved enough. Hyperopia can be corrected through the use of corrective lenses or laser surgery.<\/p>\n<div><\/div>\n<h3>Presbyopia<\/h3>\n<p><strong>Presbyopia<\/strong> is a vision problem associated with aging, in which the eye gradually loses its ability to focus on close objects. The precise\u00a0origin\u00a0of presbyopia is not known for certain, but evidence suggests that the lens may become less elastic with age, causing the\u00a0muscles\u00a0that control the lens\u00a0to\u00a0lose power as people grow older. The first signs of presbyopia \u2014 eyestrain, difficulty seeing in dim light, problems focusing on small objects and fine print \u2014 are usually first noticed between the ages of 40 and 50. Most older people with this problem use corrective lenses to focus on close objects, because surgical procedures to correct presbyopia have not been as successful as those for myopia and hyperopia.<\/p>\n<div>\n<h1>Hearing<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3151\">Hearing<\/a><\/strong>\u00a0is the ability to sense\u00a0sound waves, and the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_5977\">ear<\/a><\/strong> is the organ that senses sound. Sound waves enter the ear through the ear canal and travel to the eardrum (see the diagram of the ear Figure 8.7.9). The sound waves strike the eardrum, and make it vibrate. The vibrations then travel through the three tiny bones (incus, malleus and stapes) of the middle ear, which amplify the vibrations. From the middle ear, the vibrations pass to the cochlea in the inner ear. The <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_5949\">cochlea<\/a><\/strong>\u00a0is a coiled tube filled with\u00a0liquid. The liquid moves in response to the vibrations, causing tiny\u00a0hair\u00a0cells(which are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3124\">mechanoreceptors<\/a>) lining the cochlea to bend. In response, the hair cells send nerve impulses to the auditory nerve, which carries the impulses to the brain. The brain interprets the impulses and \u201ctells\u201d us what we are hearing.<\/p>\n<figure id=\"attachment_3154\" aria-describedby=\"caption-attachment-3154\" style=\"width: 480px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3154\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/AnatomyHumanEar-2.gif\" alt=\"\" width=\"480\" height=\"344\" \/><figcaption id=\"caption-attachment-3154\" class=\"wp-caption-text\"><em>Figure 8.7.9 Most of the structures of the ear are involved in hearing. Only the semicircular canals are not involved in hearing. Instead, they sense head position, which is used to monitor balance.<\/em><\/figcaption><\/figure>\n<div>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 1.602em; font-weight: bold;\">Balance<\/span><\/p>\n<\/div>\n<p>The ears are also responsible for the sense of balance.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3155\">Balance<\/a><\/strong>\u00a0is the ability to sense and maintain an appropriate body position. The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3156\">semicircular canals<\/a> inside the ear (see the figure\u00a0above) contain fluid that moves when the head changes position. Tiny hairs lining the semicircular canals sense movement of the fluid. In response, they send nerve impulses to the vestibular nerve, which carries the impulses to the brain. The brain interprets the impulses and sends messages to the\u00a0peripheral nervous system, which triggers contractions of\u00a0skeletal muscles\u00a0as needed to maintain balance.<\/p>\n<div>\n<h1>Taste and\u00a0Smell<\/h1>\n<\/div>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3157\"><strong>Taste<\/strong><\/a> and <strong>smell<\/strong>\u00a0are both abilities to sense chemicals, so both taste and olfactory (odor) receptors are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3128\">chemoreceptors<\/a>. Both types of chemoreceptors send nerve impulses to the brain along sensory nerves, and the brain \u201ctells\u201d us what we are tasting or smelling.<\/p>\n<p>Taste receptors are found in tiny bumps on the tongue called\u00a0<strong>taste buds.<\/strong>You can see a diagram of a taste receptor cell and related structures in Figure 8.7.10. Taste receptor cells make contact with chemicals in food through tiny openings called <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3160\">taste pores<\/a><\/strong>. When certain chemicals bind with taste receptor cells, it generates nerve impulses that travel through afferent nerves to the CNS. There are separate taste receptors for sweet, salty, sour, bitter, and meaty tastes. The meaty \u2014 or savory \u2014 taste is called umami.<\/p>\n<figure id=\"attachment_3161\" aria-describedby=\"caption-attachment-3161\" style=\"width: 532px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3161\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Taste_bud_2_eng.svg_-2.png\" alt=\"\" width=\"532\" height=\"627\" \/><figcaption id=\"caption-attachment-3161\" class=\"wp-caption-text\"><em>Figure 8.7.10 Taste receptor cells are located in taste buds on the tongue. Basal cells are not involved in tasting, but differentiate into taste receptor cells. Taste receptor cells are replaced about every nine to ten days.<\/em><\/figcaption><\/figure>\n<div>\n<figure id=\"attachment_3162\" aria-describedby=\"caption-attachment-3162\" style=\"width: 518px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3162\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Head_olfactory_nerve-2.jpg\" alt=\"Olfactory Cells\" width=\"518\" height=\"590\" \/><figcaption id=\"caption-attachment-3162\" class=\"wp-caption-text\"><em>Figure 8.7.11 The yellow structures inside this drawing of the nasal passages are an olfactory nerve with many nerve endings. The nerve endings sense chemicals in the air as it passes through the nasal cavities.<\/em><\/figcaption><\/figure>\n<\/div>\n<div>\n<h1>Feature: Human Biology in the News<\/h1>\n<\/div>\n<p>The most common cause of blindness in the Western hemisphere is\u00a0<strong><a href=\"https:\/\/www.webmd.com\/eye-health\/macular-degeneration\/age-related-macular-degeneration-overview#1\">age-related macular degeneration<\/a> (AMD).<\/strong> Approximately 1.4 million people in Canada have this type of blindness, and 196 million people are affected worldwide and is expected to increase to 288 millions people by the year 2040. At present, there is no cure for AMD. The disease occurs with the death of a layer of cells called retinal pigment epithelium, which normally provides nutrients and other support to the macula of the eye. The macula is an oval-shaped pigmented area near the center of the retina that is specialized for high visual acuity and has the retina\u2019s greatest concentration of cones. When the epithelial cells die and the macula is no longer supported or nourished, the macula also starts to die. Patients experience a black spot in the center of their vision, and as the disease progresses, the black spot grows outward. Patients eventually lose the ability to read and even to recognize familiar faces before developing total blindness.<\/p>\n<p>In 2016, a landmark surgery was performed as a trial on a patient with severe AMD. In the first ever operation of its kind, Dr. Pete Coffey of the University of London implanted a tiny patch of cells behind the retina in each of the patient\u2019s eyes. The cells were retinal pigmented epithelial cells that had been grown in a lab from\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3163\">stem cells<\/a>,<\/strong>\u00a0which are undifferentiated cells that\u00a0can\u00a0develop into other cell types.\u00a0Within\u00a0six months\u00a0of\u00a0the operation, the new cells were still surviving, and the doctor was hopeful that the patient\u2019s vision loss would stop and even be reversed. At that point, several other operations had already been planned to test the new procedure. If these cases are a success, Dr. Coffey predicts that the surgery will become as routine as cataract surgery, and that it will prevent millions of patients from losing their vision.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">8.7 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The\u00a0human body\u00a0has two major types of senses: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3122\">special senses<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3123\">general senses<\/a>. Special senses have specialized sense organs and include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3164\">vision<\/a> (eyes), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3151\">hearing<\/a> (ears), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3155\">balance<\/a> (ears), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3157\">taste<\/a> (tongue), and smell (nasal passages). General senses are all associated with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3129\">touch<\/a> and lack special sense organs. Touch receptors are found throughout the body, but particularly in the skin.<\/li>\n<li>All senses depend on sensory receptor cells to detect sensory stimuli and transform them into nerve impulses. Types of sensory receptors include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3124\">mechanoreceptors<\/a>\u00a0(mechanical forces), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3125\">thermoreceptors<\/a>\u00a0(temperature), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3126\">nociceptors<\/a>\u00a0(pain), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3127\">photoreceptors<\/a>\u00a0(light), and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3128\">chemoreceptors<\/a>\u00a0(chemicals).<\/li>\n<li>Touch\u00a0is\u00a0the ability to sense pressure, vibration,\u00a0temperature, pain, and other tactile stimuli. The skin includes several different types of touch receptor cells.<\/li>\n<li>Vision is the ability to sense light and see. The eye is the special sensory organ that collects and focuses light, forms images, and changes them to nerve impulses. Optic nerves send information from the eyes to the brain, which processes the visual information and \u201ctells\u201d us what we are seeing.<\/li>\n<li>Common vision problems include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3144\">myopia<\/a> (nearsightedness), <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3145\">hyperopia<\/a> (farsightedness), and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3165\">presbyopia<\/a> (age-related decline in close vision). Vision problems can be corrected with lenses (eyeglasses or contacts) or \u2014 in many cases \u2014 with laser surgery.<\/li>\n<li>Hearing is the ability to sense sound waves, and the ear is the organ that senses sound. It changes sound waves to vibrations that trigger nerve impulses, which travel to the brain through the auditory nerve. The brain processes the information and \u201ctells\u201d us what we are hearing.<\/li>\n<li>The ear is also the organ responsible for the sense of balance, which is the ability to sense and maintain an appropriate body position. The ears send impulses about head position to the brain, which sends messages to\u00a0skeletal muscles\u00a0via the\u00a0peripheral nervous system. The\u00a0muscles\u00a0respond by contracting to maintain balance.<\/li>\n<li>Taste and smell\u00a0are both abilities to sense chemicals. Taste receptors in taste buds on the tongue sense chemicals in food,\u00a0while\u00a0olfactory receptors in the nasal passages sense chemicals in the air.\u00a0Sense of smell contributes significantly to sense of taste.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">8.7 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li>Compare and contrast special senses and general senses.<\/li>\n<li>What are sensory receptors?<\/li>\n<li>\n<div id=\"h5p-566\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-566\" class=\"h5p-iframe\" data-content-id=\"566\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"8.7 Sensory Receptors\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Describe the\u00a0range of tactile stimuli detected in the sense of touch.<\/li>\n<li>Explain how the eye collects and focuses light to form an image, and how it converts it to nerve impulses.<\/li>\n<li>Identify two common vision problems,along with\u00a0their causes and their effects on vision.<\/li>\n<li>\n<div id=\"h5p-567\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-567\" class=\"h5p-iframe\" data-content-id=\"567\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"8.7 Eye Diagram\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Explain how structures of the ear collect and amplify sound waves and transform them to nerve impulses.<\/li>\n<li>What role does the ear play in balance? Which structures of the ear are involved in balance?<\/li>\n<li>Describe two ways that the body senses chemicals. What are the special sense organs involved in these senses?<\/li>\n<li>Explain why your skin can detect different types of stimuli, such as pressure and temperature.<\/li>\n<li>Is sensory information sent to the central nervous system via efferent or afferent nerves?<\/li>\n<li>Identify a mechanoreceptor used in two different human senses. Describe the type of mechanical stimuli that each detects.<\/li>\n<li>If a person is blind, but their retina is functioning properly, where do you think the damage might be? Explain your answer.<\/li>\n<li>When you see colours, what receptor cells are activated? Where are these receptors located? What lobe of the brain is primarily used to process visual information?<\/li>\n<li>The auditory nerve carries _______________.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li style=\"list-style-type: none;\">\n<ol type=\"a\">\n<li>smell information<\/li>\n<li>taste information<\/li>\n<li>balance information<\/li>\n<li>sound information<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">8.7 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"What color is Tuesday? Exploring synesthesia - Richard E. Cytowic\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/rkRbebvoYqI?start=4&#38;feature=oembed\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">What color is Tuesday? Exploring synesthesia &#8211; Richard E. Cytowic, TED-Ed, 2013.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"What Is Vertigo &amp; Why Do We Get It?\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/UL8YSLhqa5U?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">What Is Vertigo &amp; Why Do We Get It?, Seeker, 2016.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-3\" title=\"How do animals see in the dark? - Anna St\u00f6ckl\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/t3CjTU7TaNA?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">How do animals see in the dark? &#8211; Anna St\u00f6ckl, TED-Ed,\u00a0 2016.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-4\" title=\"What are those floaty things in your eye? - Michael Mauser\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/Y6e_m9iq-4Q?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">What are those floaty things in your eye? &#8211; Michael Mauser, TED-Ed, 2014.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 8.7.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/78717264@N00\/2361310483\/in\/photostream\/\" rel=\"cc:attributionURL\">Bee Stereogram<\/a>\u00a0by\u00a0<a href=\"https:\/\/www.flickr.com\/photos\/78717264@N00\/\" rel=\"dc:creator\">Be Mosaic<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 8.7.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0809_Skin_TactileReceptors.png\" rel=\"cc:attributionURL\">Skin_TactileReceptors<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 8.7.3<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/jxQFMN7xzJc\">Macro shot photograph of someone&#8217;s right eye <\/a>[photo] by <a href=\"https:\/\/unsplash.com\/@whitfieldjordan?utm_source=unsplash&amp;utm_medium=referral&amp;utm_content=creditCopyText\" rel=\"dc:creator\">Jordan Whitfield<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 8.7.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0388_EyeAnatomy_01.png\" rel=\"cc:attributionURL\">EyeAnatomy_01<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 8.7.5<\/strong><\/p>\n<p>RGB colours [screenshots] from Microsoft Paint.<\/p>\n<p><strong>Figure 8.7.6<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/wpi3sDUrSEk\" rel=\"cc:attributionURL\">Through the reading glasses<\/a>\u00a0[photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@ratushny\">Dmitry Ratushny<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 8.7.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Myopia_Diagram.jpg\" rel=\"cc:attributionURL\">Myopia_Diagram<\/a> by <a class=\"owner-name truncate no-outline\" title=\"Go to National Eye Institute's photostream\" href=\"https:\/\/www.flickr.com\/photos\/nationaleyeinstitute\/\" data-track=\"attributionNameClick\">National Eye Institute<\/a>\/ National Institutes of Health on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 8.7.8<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Hyperopia.gif\" rel=\"cc:attributionURL\">Hyperopia<\/a> by <a href=\"https:\/\/www.nei.nih.gov\/\">National Institute of Health\/NIH<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 8.7.9<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:AnatomyHumanEar.gif\" rel=\"cc:attributionURL\">AnatomyHumanEar<\/a> by unknown author from <a href=\"https:\/\/www.osha.gov\/dts\/osta\/otm\/new_noise\/\">Occupational Safety &amp; Health Administration<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong style=\"text-align: initial; font-size: 1em;\">Figure 8.7.10<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Taste_bud_2_eng.svg\" rel=\"cc:attributionURL\">Taste_bud_2_eng.svg<\/a> by <a class=\"new\" title=\"User:Jonas T\u00f6le (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Jonas_T%C3%B6le&amp;action=edit&amp;redlink=1\">Jonas T\u00f6le<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> Universal Public Domain Dedication license (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en).<\/p>\n<p><strong style=\"text-align: initial; font-size: 1em;\"><br \/>\nFigure 8.7.11<br \/>\n<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Head_olfactory_nerve.jpg\" rel=\"cc:attributionURL\">Head_olfactory_nerve<\/a> by <a class=\"mw-userlink\" title=\"User:Patrick.lynch\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Patrick.lynch\">Patrick.lynch<\/a>, medical illustrator on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en\" rel=\"license\">CC BY 2.5<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Age-Related Macular Degeneration. (n.d.). WebMD. https:\/\/www.webmd.com\/eye-health\/macular-degeneration\/age-related-macular-degeneration-overview#3 (Reviewed by Alan Kozarsky, MD on October 26, 2019)<\/p>\n<p class=\"hanging-indent\">Blausen.com Staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">da Cruz, L., Fynes, K., Georgiadis, O. et al. (2018, March 19). Phase 1 clinical study of an embryonic stem cell\u2013derived retinal pigment epithelium patch in age-related macular degeneration. <em>Natural Biotechnology, 36<\/em>, 328\u2013337. https:\/\/doi.org\/10.1038\/nbt.4114<\/p>\n<p class=\"hanging-indent\">File:Eye Diagram without text.gif. (2018, February 9).\u00a0<i>Wikimedia Commons.<\/i> https:\/\/commons.wikimedia.org\/w\/index.php?title=File:Eye_Diagram_without_text.gif&amp;oldid=286008241 (original image from\u00a0National Eye Institute\u00a0&#8211; modified by\u00a0User:Nordelch) [public domain (https:\/\/en.wikipedia.org\/wiki\/Public_domain)]<\/p>\n<p class=\"hanging-indent\">Occupational Health and Safety Administration. (n.d.). Figure 7. Anatomy of the human ear [diagram]. In <em>OSHA Technical Manual<\/em> (Section III, Chapter 5 &#8211; Noise). United States Department of Labour [online]. https:\/\/www.osha.gov\/dts\/osta\/otm\/new_noise\/<\/p>\n<p class=\"hanging-indent\">Seeker. (2016, March 18). What is vertigo &amp; why do we get it? YouTube. https:\/\/www.youtube.com\/watch?v=UL8YSLhqa5U&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2013, June 10). What color is Tuesday? Exploring synesthesia &#8211; Richard E. Cytowic. YouTube. https:\/\/www.youtube.com\/watch?v=rkRbebvoYqI&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2014, December 1). What are those floaty things in your eye? &#8211; Michael Mauser. YouTube. https:\/\/www.youtube.com\/watch?v=Y6e_m9iq-4Q&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2016, August 25). How do animals see in the dark? &#8211; Anna St\u00f6ckl\u200b. YouTube. https:\/\/www.youtube.com\/watch?v=t3CjTU7TaNA&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4794_3121\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3121\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4704\" aria-describedby=\"caption-attachment-4704\" style=\"width: 357px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4704\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Chimneys-by-angela-baker-awlR2geeTGs-unsplash-scaled-2.jpg\" alt=\"16.2.1 Chimneys\" width=\"357\" height=\"500\"><figcaption id=\"caption-attachment-4704\" class=\"wp-caption-text\"><em>Figure 16.2.1 Chimney view.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Getting Rid of Wastes<\/h1>\n<\/div>\n<p>The many chimneys on these houses are one way that the inhabitants of the home get rid of the wastes they produce. The chimneys expel waste gases that are created when they burn fuel in their furnace or fireplace. Think about the other wastes that people create in their homes and how we dispose of them. Solid trash and recyclables may go to the curb in a trash can, or in a recycling bin for pick up and transport to a landfill or recycling centre. Wastewater from sinks, showers, toilets, and the washing machine goes into a main sewer pipe and out of the house to join the community\u2019s sanitary sewer system.<\/p>\n<p>Like a busy home, your body also produces a lot of wastes that must be eliminated. Like a home,\u00a0the way\u00a0your body gets rid of wastes depends on the nature of the waste products. Some\u00a0human body\u00a0wastes are gases, some are solids, and some are in a\u00a0liquid\u00a0state. Getting rid of body wastes is called excretion, and there are a number of different\u00a0organs of excretion in the human body.<\/p>\n<div>\n<h3>Excretion<\/h3>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4705\">Excretion<\/a><\/strong>\u00a0is the process of removing wastes and excess\u00a0water\u00a0from the body. It is an essential process in all living things, and it is one of the major ways the\u00a0human body\u00a0maintains\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a>. It also helps prevent damage to the body. Wastes include by-products of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_176\">metabolism<\/a> \u2014 some of which are toxic \u2014 and other non-useful materials, such as used up and broken down components. Some of the specific waste products that must be excreted from the body include carbon dioxide from\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1172\">cellular respiration<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4707\">ammonia<\/a> and\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a><\/strong>\u00a0from\u00a0protein\u00a0catabolism, and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4709\"><strong>uric\u00a0acid<\/strong><\/a>\u00a0from\u00a0nucleic acid\u00a0catabolism.<\/p>\n<div>\n<h3>Excretory Organs<\/h3>\n<\/div>\n<p>Organs of excretion include the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3521\">skin<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2989\">liver<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4560\">large intestine<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2990\">lungs<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a> (see Figure 16.2.2). Together, these organs make up the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2915\">excretory system<\/a><\/strong>.\u00a0They all\u00a0excrete wastes, but they don\u2019t work together in the same way that organs do in most other body systems. Each of the excretory organs \u201cdoes its own thing\u201d more-or-less independently of the others, but all are necessary to successfully excrete the full range of wastes from the\u00a0human body.<\/p>\n<div id=\"h5p-191\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-191\" class=\"h5p-iframe\" data-content-id=\"191\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Passive Transport\"><\/iframe><\/div>\n<\/div>\n<div>\n<p><em>Figure 16.2.2 Internal organs of excretion are identified in this illustration. They include the skin, liver, large intestine, lungs, and kidneys.<\/em><\/p>\n<\/div>\n<h2>Skin<\/h2>\n<figure id=\"attachment_4712\" aria-describedby=\"caption-attachment-4712\" style=\"width: 421px\" class=\"wp-caption alignright\"><img class=\" wp-image-4712\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/gym_room_fitness_equipment_cardiovascular_exercise_elliptical_bike_cardio_training_sports_equipment_bodybuilding-825364-1.jpg\" alt=\"16.2.3 Sweating\" width=\"421\" height=\"301\"><figcaption id=\"caption-attachment-4712\" class=\"wp-caption-text\"><em>Figure 16.2.3 The purpose of sweat production is mainly to cool the body and prevent overheating, but it also contributes to excretion.<\/em><\/figcaption><\/figure>\n<p>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3521\">skin<\/a> is part of the integumentary system, but it also plays a role in excretion through the production of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4711\">sweat<\/a> by sweat glands in the dermis. Although the main role of sweat production is to cool the body and maintain temperature <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a>, sweating also eliminates excess water and salts, as well as a small amount of urea. When sweating is copious, as in Figure 16.2.3, ingestion of salts and water may be helpful to maintain homeostasis in the body.<\/p>\n<h2>Liver<\/h2>\n<figure id=\"attachment_4713\" aria-describedby=\"caption-attachment-4713\" style=\"width: 333px\" class=\"wp-caption alignleft\"><img class=\" wp-image-4713\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/liver-2934612_1280-1.png\" alt=\"16.2.4 LIver\" width=\"333\" height=\"233\"><figcaption id=\"caption-attachment-4713\" class=\"wp-caption-text\"><em>Figure 16.2.4 The liver is an organ of excretion.<\/em><\/figcaption><\/figure>\n<p>The liver (shown in Figure 16.2.4) has numerous major functions, including secreting <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4599\">bile<\/a> for digestion of lipids, synthesizing many proteins and other compounds, storing glycogen and other substances, and secreting endocrine hormones. In addition to all of these functions, the liver is a very important organ of excretion. The liver breaks down many substances in the blood, including toxins. For example, the liver transforms <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4707\">ammonia<\/a> \u2014 a poisonous by-product of protein <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_178\">catabolism<\/a> \u2014 into <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, which is filtered from the blood by the kidneys and excreted in urine. The liver also excretes in its bile the protein <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4715\">bilirubin<\/a>,<\/strong>\u00a0a byproduct of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3556\">hemoglobin<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_178\">catabolism<\/a> that forms when red\u00a0blood\u00a0cells\u00a0die. Bile travels to the\u00a0small intestine\u00a0and is then excreted in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4636\">feces<\/a> by the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4560\">large intestine<\/a>.<\/p>\n<h2>Large Intestine<\/h2>\n<p>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4560\">large intestine<\/a> is an important part of the digestive system and the final organ in the gastrointestinal tract. As an organ of excretion, its main function is to eliminate solid wastes that remain after the digestion of food and the extraction of water from indigestible matter in food waste. The large intestine also collects wastes from throughout the body. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4599\">Bile<\/a> secreted into the gastrointestinal tract, for example, contains the waste product <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4715\">bilirubin<\/a> from the liver. Bilirubin is a brown pigment that gives human <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4636\">feces<\/a> its characteristic brown colour.<\/p>\n<h2>Lungs<\/h2>\n<p>The lungs are part of the respiratory system (shown in Figure 16.2.5), but they are also important organs of excretion. They are responsible for the excretion of gaseous wastes from the body. The main waste gas excreted by the lungs is carbon dioxide, which is a waste product of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1172\">cellular respiration<\/a> in cells throughout the body. Carbon dioxide is diffused from the blood into the air in the tiny air sacs called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4311\">alveoli<\/a> in the lungs (shown in the inset diagram). By expelling carbon dioxide from the blood, the lungs help maintain acid-base <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a>. In fact, it is the pH of blood that controls the rate of breathing. Water vapor is also picked up from the lungs and other organs of the respiratory tract as the exhaled air passes over their moist linings, and the water vapor is excreted along with the carbon dioxide. Trace levels of some other waste gases are exhaled, as well.<\/p>\n<figure id=\"attachment_8003\" aria-describedby=\"caption-attachment-8003\" style=\"width: 699px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-8003\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/1024px-Respiratory_System_Illustration-1.png\" alt=\"16.2.5 Respiratory System\" width=\"699\" height=\"524\"><figcaption id=\"caption-attachment-8003\" class=\"wp-caption-text\">Figure 16.2.5 The alveoli are the functional structures in the lungs where gaseous wastes enter the air from the blood.<\/figcaption><\/figure>\n<h2>Kidneys<\/h2>\n<p>The paired kidneys are often considered the main organs of excretion. The primary function of the kidneys is the elimination of excess water and wastes from the bloodstream by the production of the\u00a0liquid\u00a0waste known as\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a><\/strong>. The main structural and functional units of the kidneys are tiny structures called nephrons.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">Nephrons<\/a><\/strong> filter materials out of the blood, return to the blood what is needed, and excrete the rest as urine. As shown in Figure 16.2.6, the kidneys are organs of the urinary system, which also includes the ureters, bladder, and urethra \u2014 organs that transport, store, and eliminate urine, respectively.<\/p>\n<figure id=\"attachment_4719\" aria-describedby=\"caption-attachment-4719\" style=\"width: 512px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-4719\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/512px-Urinary_System_Female-1.png\" alt=\"16.2.6 Urinary System\" width=\"512\" height=\"683\"><figcaption id=\"caption-attachment-4719\" class=\"wp-caption-text\"><em>Figure 16.2.6 The urinary system consists of two kidneys and the structures that transport and store urine.<\/em><\/figcaption><\/figure>\n<p>By producing and excreting urine, the kidneys play vital roles in body-wide <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a>. They maintain the correct volume of extracellular fluid, which is all the fluid in the body outside of cells, including the blood and lymph. The kidneys also maintain the correct balance of salts and pH in extracellular fluid. In addition, the kidneys function as endocrine glands, secreting hormones into the blood that control other body processes. You can read much more about the kidneys in section <a href=\"http:\/\/humanbiology.pressbooks.tru.ca\/chapter\/18-4-kidneys\/\">16.4 Kidneys<\/a>.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.2 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4705\">Excretion<\/a> is the process of removing wastes and excess water from the body. It is an essential process in all living things and a major way the human body maintains <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a>.<\/li>\n<li>Organs of excretion include the skin, liver, large intestine, lungs, and kidneys. All of them excrete wastes, and together they make up the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2915\">excretory system<\/a>.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3521\">skin<\/a> plays a role in excretion through the production of sweat by sweat glands. Sweating eliminates excess water and salts, as well as a small amount of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, a byproduct of\u00a0protein\u00a0catabolism.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2989\">liver<\/a> is a very important organ of excretion. The liver breaks down many substances in the blood, including toxins. The liver also excretes <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4715\">bilirubin<\/a> \u2014 a waste product of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3556\">hemoglobin<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_178\">catabolism<\/a> \u2014 in bile. Bile then travels to the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4559\">small intestine<\/a>, and is eventually excreted in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4636\">feces<\/a> by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4560\">large intestine<\/a>.<\/li>\n<li>The main excretory function of the large intestine is to eliminate\u00a0solid waste that remains after food is digested and water is extracted from the indigestible matter. The large intestine also collects and excretes wastes from throughout the body, including bilirubin in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4599\">bile<\/a>.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2990\">lungs<\/a> are responsible for the excretion of gaseous wastes, primarily carbon dioxide from\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1172\">cellular respiration<\/a>\u00a0in cells throughout the body. Exhaled air also contains water vapor and trace levels of some other waste gases.<\/li>\n<li>The paired <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a> are often considered the main organs of excretion. Their primary function is the elimination of excess water and wastes from the bloodstream by the production of urine. The kidneys contain tiny structures called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephrons<\/a>\u00a0that filter materials out of the blood, return to the blood what is needed, and excrete the rest as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>. The kidneys are part of the\u00a0urinary system, which also includes the\u00a0ureters, urinary bladder, and urethra.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.2 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is excretion, and what is its significance?<\/li>\n<li>\n<div id=\"h5p-192\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-192\" class=\"h5p-iframe\" data-content-id=\"192\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"11.2 Axial and Appendicular Skeleton\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Describe the excretory functions of the liver.<\/li>\n<li>What are\u00a0the main excretory functions of the large intestine?<\/li>\n<li>List organs of the urinary system.<\/li>\n<li>Describe the physical states in which the wastes from the human body are excreted.<\/li>\n<li>Give one example of why ridding the body of excess water is important.<\/li>\n<li>What gives feces its brown colour? Why is that substance produced?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.2 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=erMCADOJcHk&amp;feature=youtu.be<\/p>\n<p style=\"text-align: center\">Why Can We Regrow A Liver (But Not A Limb)? MITK12Videos, 2015.<\/p>\n<p style=\"text-align: center\">https:\/\/www.youtube.com\/watch?v=SeK0zFB9yHg&amp;feature=youtu.be<\/p>\n<p style=\"text-align: center\">Are Sports Drinks Good For You? | Fit or Fiction, POPSUGAR Fitness, 2014.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=fctH_1NuqCQ&amp;feature=youtu.be<\/p>\n<p style=\"text-align: center\">Why do we sweat? - John Murnan, TED-Ed, 2018.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 16.2.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/awlR2geeTGs\">Chimneys\/ <span class=\"_20NLS _1ByhS\">Kingston upon Hull, England<\/span><\/a> [photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@angyv\">Angela Baker<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 16.2.2<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/kullez\/5598159209\/in\/photolist-c4n2DS-c4n3nL-9wG2Gn-7J76c4-c4n4HW-c4n42S\">Sweat or rain?<\/a> by <a class=\"owner-name truncate\" title=\"Go to Kullez's photostream\" href=\"https:\/\/www.flickr.com\/photos\/kullez\/\" data-track=\"attributionNameClick\">Kullez<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/).<\/li>\n<li><a href=\"http:\/\/www.medicalgraphics.de\/en\/free-pictures\/organs\/kidney-front-white.html\">Kidney front - white<\/a> from <a href=\"http:\/\/www.medicalgraphics.de\/\">www.medicalgraphics.de<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/\">CC BY-ND 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/) license.<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Liver_Cirrhosis.png\">File:Liver Cirrhosis.png<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Human_lungs.png\">File:Human lungs.png<\/a> by <a class=\"new\" title=\"User:Sharanyaudupa (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Sharanyaudupa&amp;action=edit&amp;redlink=1\">Sharanyaudupa<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/pixabay.com\/illustrations\/offal-marking-medical-intestine-1463369\/\">Tags: Offal Marking Medical Intestine Liver<\/a> by <a class=\"hover_opacity\" href=\"https:\/\/pixabay.com\/users\/Elionas2-1238490\/\">Elionas2<\/a> on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay license<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/li>\n<\/ul>\n<\/div>\n<p><strong>Figure 16.2.3<\/strong><\/p>\n<div>\n<p><a href=\"https:\/\/pxhere.com\/en\/photo\/825364\" rel=\"cc:attributionURL\">gym_room_fitness_equipment_cardiovascular_exercise_elliptical_bike_cardio_training_sports_equipment_bodybuilding-825364<\/a> from <a href=\"http:\/\/pxhere.com\">Pxhere<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\">CC0 1.0<\/a> Universal public domain dedication license (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/).<\/p>\n<p><strong>Figure 16.2.4<\/strong><\/p>\n<p><a href=\"https:\/\/pixabay.com\/illustrations\/liver-organ-anatomy-2934612\/\">Tags: Liver Organ Anatomy<\/a> by <a class=\"hover_opacity\" href=\"https:\/\/pixabay.com\/users\/zachvanstone8-4958962\/\">zachvanstone8<\/a> on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/p>\n<p><strong>Figure 16.2.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Lung_and_diaphragm.jpg\" rel=\"cc:attributionURL\">Lung_and_diaphragm<\/a> by Terese Winslow\/ <a href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=7235\">National Cancer Institute<\/a> on Wikimedia Commons is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.2.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Urinary_System_(Female).png\" rel=\"cc:attributionURL\">512px-Urinary_System_(Female)<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><span style=\"font-size: 1.424em;font-weight: bold\"><br \/>\nReferences<\/span><\/p>\n<p class=\"hanging-indent\">MITK12Videos. (2015, June 4). Why can we regrow a liver (but not a limb)? https:\/\/www.youtube.com\/watch?v=erMCADOJcHk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">POPSUGAR Fitness. (2014, February 7). Are sports drinks good for you? | Fit or Fiction. YouTube. https:\/\/www.youtube.com\/watch?v=SeK0zFB9yHg&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2018, May 15). Why do we sweat? - John Murnan. YouTube. https:\/\/www.youtube.com\/watch?v=fctH_1NuqCQ&amp;feature=youtu.be<\/p>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3122\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3122\"><div tabindex=\"-1\"><p>As per caption<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3123\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3123\"><div tabindex=\"-1\"><p>Image shows a detailed labelled diagram of a kidney.  There is a tough outer layer called the capsule.  The cortex contains blood vessels and the medulla contains nephrons.  The renal artery brings blood from the heart to the kidney, and this blood is returned to the heart via the renal vein.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3006\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3006\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4487\" aria-describedby=\"caption-attachment-4487\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4487\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/vampire_PNG32-1.png\" alt=\"14.5.1\" width=\"400\" height=\"316\"><figcaption id=\"caption-attachment-4487\" class=\"wp-caption-text\"><em>Figure 14.5.1 \"I want to suck your blood.\"<\/em><\/figcaption><\/figure>\n<div>\n<h1>Vampires<\/h1>\n<\/div>\n<p>From Bram Stoker\u2019s famous novel about Count Dracula, to films such as <em>Van Helsing<\/em> and the <em>Twilight<\/em> Saga<em>,<\/em> fantasies featuring vampires (like the one in Figure 14.5.1) have been popular for decades. Vampires, in fact, are found in centuries-old myths from many cultures. In such myths, vampires are generally described as creatures that drink blood \u2014 preferably of the human variety \u2014 for sustenance. Dracula, for example, is based on Eastern European folklore about a human who attains immortality (and eternal damnation) by drinking the blood of others.<\/p>\n<div>\n<h1>What Is Blood?<\/h1>\n<\/div>\n<figure id=\"attachment_4489\" aria-describedby=\"caption-attachment-4489\" style=\"width: 397px\" class=\"wp-caption alignleft\"><img class=\"wp-image-4489 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blood-centrifugation-scheme-1.png\" alt=\"14.5.2 Components of Blood\" width=\"397\" height=\"530\"><figcaption id=\"caption-attachment-4489\" class=\"wp-caption-text\">Figure 14.5.2 If blood is centrifuged (spun at high speed), it separates into its major components based on density, as shown here: plasma, leukocytes (white blood cells) and platelets, and erythrocytes (red blood cells). All blood normally contains these components in about the same proportions.<\/figcaption><\/figure>\n<p>The average adult body contains between 4.7 and 5.7 litres of blood. More than half of that amount is fluid. Most of the rest of that amount consists of blood cells. The relative amounts of the various components in blood are illustrated in Figure 14.5.2. The components are also described in detail below.<\/p>\n<div>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2702\"><strong>Blood<\/strong><\/a><span style=\"text-align: initial;font-size: 1em\">\u00a0is a fluid connective tissue that circulates throughout the body through blood vessels of the cardiovascular system. What makes blood so special that it features in widespread myths? Although blood accounts for less than 10% of human body weight, it is quite literally the elixir of life. As blood travels through the vessels of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3835\">cardiovascular system<\/a>, it delivers vital substances (such as nutrients and oxygen) to all of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3573\">cells<\/a>, and carries away their metabolic wastes. It is no exaggeration to say that without blood, cells could not survive. Indeed, without the oxygen carried in blood, cells of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3823\">brain<\/a> start to die within a matter of minutes.<\/span><\/p>\n<h1>Functions of Blood<\/h1>\n<\/div>\n<p>Blood performs many important functions in the body. Major functions of blood include:<\/p>\n<ul>\n<li>Supplying tissues with oxygen, which is needed by all cells for <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3785\">aerobic cellular respiration<\/a>.<\/li>\n<li>Supplying cells with nutrients, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3359\">glucose<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3615\">amino acids<\/a>, and fatty acids.<\/li>\n<li>Removing metabolic wastes from cells, including carbon dioxide, urea, and lactic acid.<\/li>\n<li>Helping to defend the body from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3707\">pathogens<\/a> and other foreign substances.<\/li>\n<li>Forming clots to seal broken blood vessels and stop bleeding.<\/li>\n<li>Transporting <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3569\">hormones<\/a> and other messenger molecules.<\/li>\n<li>Regulating the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4330\">pH<\/a> of the body, which must be kept within a narrow range (7.35 to 7.45).<\/li>\n<li>Helping regulate body temperature (through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3942\">vasoconstriction<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2756\">vasodilation<\/a>).<\/li>\n<\/ul>\n<div>\n<h1>Blood\u00a0Plasma<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4395\">Plasma<\/a><\/strong> is the liquid component of human blood. It makes up about 55% of blood by volume. It is about 92% water, and contains many dissolved substances. Most of these substances are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3721\">protein<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">, but plasma also contains trace amounts of glucose, mineral ions, hormones, carbon dioxide, and other substances. In addition, plasma contains blood cells. When the cells are removed from plasma, as in Figure 14.5.2 above, the remaining liquid is clear but yellow in colour.<\/span><\/p>\n<div>\n<h1>Blood Cells<\/h1>\n<\/div>\n<p>The cells in blood include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4398\">erythrocytes<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3531\">leukocytes<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4399\">thrombocytes<\/a>. These different types of blood cells are shown in the photomicrograph (Figure 14.5.3) and described in the sections that follow.<\/p>\n<figure id=\"attachment_4490\" aria-describedby=\"caption-attachment-4490\" style=\"width: 402px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4490\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/SEM_blood_cells-1.jpg\" alt=\"14.5.3 SEM Blood Cells\" width=\"402\" height=\"500\"><figcaption id=\"caption-attachment-4490\" class=\"wp-caption-text\"><em>Figure 14.5.3 Highly magnified blood cells in this image include doughnut-shaped red blood cells, rough-surfaced white blood cells, and small disc-shaped platelets.<\/em><\/figcaption><\/figure>\n<h2>Erythrocytes<\/h2>\n<p>The most numerous cells in blood are\u00a0red blood cells<strong>,<\/strong>\u00a0also called <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4398\">erythrocyte<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">. One microlitre of blood contains between 4.2 and 6.1 million red blood cells, and red blood cells make up about 25% of all the cells in the human body. The cytoplasm of a mature erythrocyte is almost completely filled with hemoglobin, the iron-containing protein that binds with oxygen and gives the cell its red colour. In order to provide maximum space for hemoglobin, mature erythrocytes lack a cell <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3705\">nucleus<\/a> and most <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3465\">organelle<\/span><span style=\"font-size: 1em\">s<\/span><span style=\"font-size: 1em;text-align: initial\"><\/a><\/span><span style=\"font-size: 1em;text-align: initial\">. They are little more than sacks of hemoglobin.<\/span><\/p>\n<p>Erythrocytes also carry proteins called antigens that determine blood type. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2703\">Blood type<\/a> is a genetic characteristic. The best known human blood type systems are the ABO and Rhesus systems.<\/p>\n<ul>\n<li>In the ABO system, there are two common antigens, called antigen A and antigen B. There are four ABO blood types, A (only A antigen), B (only B antigen), AB (both A and B antigens), and O (neither A nor B antigen). The ABO antigens are illustrated in Figure 14.5.4.<\/li>\n<li>In the Rhesus system, there is just one common antigen. A person may either have the antigen (Rh+) or lack the antigen (Rh-).<\/li>\n<\/ul>\n<figure id=\"attachment_4491\" aria-describedby=\"caption-attachment-4491\" style=\"width: 856px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4491\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/ABO_blood_type.svg_-1-2.png\" alt=\"14.5.4 ABO Blood Group\" width=\"856\" height=\"550\"><figcaption id=\"caption-attachment-4491\" class=\"wp-caption-text\"><em>Figure 14.5.4 Each of the ABO blood types is characterized by different glycoproteins on red blood cells.<\/em><\/figcaption><\/figure>\n<p>Blood type\u00a0is important for medical reasons. A person who needs a blood transfusion must receive blood of a compatible type. Blood that is compatible lacks antigens that the patient's own blood also lacks. For example, for a person with type A blood (no B antigen), compatible types include any type of blood that lacks the B antigen. This would include type A blood or type O blood, but not type AB or type B blood. If incompatible blood is transfused, it may cause a potentially life-threatening reaction in the patient\u2019s blood.<\/p>\n<h2>Leukocytes<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3531\">Leukocyte<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">\u00a0(also called white blood cells)<\/span><span style=\"text-align: initial;font-size: 1em\"> are cells in blood that defend the body against invading microorganisms and other threats. There are far fewer leukocytes than red blood cells in blood. There are normally only about 1,000 to 11,000 white blood cells per microlitre of blood. Unlike erythrocytes, leukocytes have a nucleus. White blood cells are part of the body\u2019s immune system. They destroy and remove old or abnormal cells and cellular debris, as well as attack pathogens and foreign substances. There are five main types of white blood cells, which are described in Table 14.5.1: neutrophils, eosinophils, basophils, lymphocytes, and monocytes. The five types differ in their specific immune functions.<\/span><\/p>\n<table class=\"grid\" style=\"width: 100%;height: 159px\">\n<caption>Table 14.5.1: Major Types of White Blood Cells<\/caption>\n<tbody>\n<tr style=\"height: 59px\">\n<th scope=\"col\">Type of Leukocyte<\/th>\n<th scope=\"col\">Per cent of All Leukocytes<\/th>\n<th scope=\"col\">Main Function(s)<\/th>\n<\/tr>\n<tr style=\"height: 14px\">\n<td>Neutrophil<\/td>\n<td>62%<\/td>\n<td>Phagocytize (engulf and destroy) bacteria and fungi in blood.<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td>Eosinophil<\/td>\n<td>\u00a0 2%<\/td>\n<td>Attack and kill large parasites; carry out allergic responses.<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td>Basophil<\/td>\n<td>\u00a0less than 1%<\/td>\n<td>Release histamines in inflammatory responses.<\/td>\n<\/tr>\n<tr style=\"height: 30px\">\n<td>Lymphocyte<\/td>\n<td>30%<\/td>\n<td>Attack and destroy virus-infected and tumor cells; create lasting immunity to specific pathogens.<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td>Monocyte<\/td>\n<td>\u00a0 5%<\/td>\n<td>Phagocytize pathogens and debris in tissues.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Thrombocytes<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4399\">Thrombocyte<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a>,<\/strong><span style=\"text-align: initial;font-size: 1em\"> also called platelets, are actually cell fragments. Like erythrocytes, they lack a nucleus and are more numerous than white blood cells. There are about 150 thousand to 400 thousand thrombocytes per microlitre of blood.<\/span><\/p>\n<p>The main function of thrombocytes is blood clotting, or <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4492\">coagulation<\/a>.<\/strong>\u00a0This is the process by which blood changes from a\u00a0liquid\u00a0to a gel, forming a plug in a damaged blood vessel. If blood clotting is successful, it results in\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4493\">hemostasis<\/a><\/strong>, which is the cessation of blood loss from the damaged vessel. A blood clot consists of both platelets and proteins, especially the protein fibrin. You can see a scanning electron microscope photomicrograph of a blood clot in Figure 14.5.5.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_4494\" aria-describedby=\"caption-attachment-4494\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4494\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blood_clot_in_scanning_electron_microscopy-1.jpg\" alt=\"14.5.5 Blood Clot\" width=\"400\" height=\"271\"><figcaption id=\"caption-attachment-4494\" class=\"wp-caption-text\"><em>Figure 14.5.5 Erythrocytes become trapped in a coagulating clot so they cannot escape through a break in a blood vessel.<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_4496\" aria-describedby=\"caption-attachment-4496\" style=\"width: 311px\" class=\"wp-caption alignleft\"><img class=\" wp-image-4496\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0740_Platelets-1.png\" alt=\"14.5.6 Activated Thrombocytes\" width=\"311\" height=\"311\"><figcaption id=\"caption-attachment-4496\" class=\"wp-caption-text\"><em>Figure 14.5.6 The shape of platelets (thrombocytes) after they are activated helps them to stick together and form a plug for a damaged blood vessel.<\/em><\/figcaption><\/figure>\n<p>Coagulation begins almost instantly after an injury occurs to the endothelium of a blood vessel. Thrombocytes become activated and change their shape from spherical to star-shaped, as shown in Figure 14.5.6. This helps them aggregate with one another (stick together) at the site of injury to start forming a plug in the vessel wall. Activated thrombocytes also release substances into the blood that activate additional thrombocytes and start a sequence of reactions leading to fibrin formation. Strands of fibrin crisscross the platelet plug and strengthen it, much as rebar strengthens concrete.<\/p>\n<figure id=\"attachment_4651\" aria-describedby=\"caption-attachment-4651\" style=\"width: 675px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4651\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Platelet_Party_900x-1.png\" alt=\"Platelet Party\" width=\"675\" height=\"821\"><figcaption id=\"caption-attachment-4651\" class=\"wp-caption-text\"><em>Figure 14.5.7 Image by Nick Seluk\/ <a href=\"http:\/\/theAwkwardYeti.com\">theAwkwardYeti.com<\/a>. (c) Used with permission.<\/em><\/figcaption><\/figure>\n<h2>Formation and Degradation of Blood Cells<\/h2>\n<p>Blood is considered a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2815\">connective tissue<\/a>, because blood cells form inside\u00a0bones. All three types of blood cells are made in red marrow within the medullary cavity of bones in a process called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3961\">hematopoiesis<\/a><\/strong>. Formation of blood cells occurs by the proliferation of stem cells in the marrow. These stem cells are self-renewing \u2014 when they divide, some of the daughter cells remain stem cells, so the pool of stem cells is not used up. Other daughter cells follow various pathways to differentiate into the variety of blood cell types. Once the cells have differentiated, they cannot divide to form copies of themselves.<\/p>\n<p>Eventually, blood cells die and must be replaced through the formation of new blood cells from proliferating stem cells. After blood cells die, the dead cells are phagocytized (engulfed and destroyed) by white blood cells, and removed from the\u00a0circulation. This process most often takes place in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4497\">spleen<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2989\">liver<\/a>.<\/p>\n<div>\n<h1>Blood Disorders<\/h1>\n<\/div>\n<p>Many human disorders primarily affect the blood. They include cancers,\u00a0genetic disorders, poisoning by toxins, infections, and nutritional deficiencies.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4498\">Leukemia<\/a><\/strong> is a group of cancers of the blood-forming tissues in the bone marrow. It is the most common type of cancer in children, although most cases occur in adults. Leukemia is generally characterized by large numbers of abnormal leukocytes. Symptoms may include excessive bleeding and bruising, fatigue, fever, and an increased risk of infections. Leukemia is thought to be caused by a combination of genetic and environmental factors.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4499\">Hemophilia<\/a><\/strong>\u00a0refers to any of several\u00a0genetic disorders\u00a0that cause dysfunction in the blood clotting process. People with hemophilia are prone to potentially uncontrollable bleeding, even with otherwise inconsequential injuries. They also commonly suffer bleeding into the spaces between\u00a0joints, which can cause crippling.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4500\">Carbon monoxide poisoning<\/a><\/strong> occurs when inhaled carbon monoxide (in fumes from a faulty home furnace or car exhaust, for example) binds irreversibly to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3556\">hemoglobin<\/a> in erythrocytes. As a result, oxygen cannot bind to the red blood cells for transport throughout the body, and this can quickly lead to suffocation. Carbon monoxide is extremely dangerous, because it is colourless and odorless, so it cannot be detected in the air by human senses.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4501\">HIV<\/a><\/strong> is a virus that infects certain types of leukocytes and interferes with the body\u2019s ability to defend itself from pathogens and other causes of illness. HIV infection may eventually lead to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3523\">AIDS<\/a> (acquired immunodeficiency syndrome). AIDS is characterized by rare infections and cancers that people with a healthy immune system almost never acquire.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3449\">Anemia<\/a><\/strong> is a disorder in which the blood has an inadequate volume of erythrocytes, reducing the amount of oxygen that the blood can carry, and potentially causing weakness and fatigue. These and other signs and symptoms of anemia are shown in Figure 14.5.8. Anemia has many possible causes, including excessive bleeding, inherited disorders (such as sickle cell hemoglobin), or nutritional deficiencies (iron, folate, or B12). Severe anemia may require transfusions of donated blood.<\/li>\n<\/ul>\n<figure id=\"attachment_4502\" aria-describedby=\"caption-attachment-4502\" style=\"width: 623px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4502\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Symptoms_of_anemia.svg_-1.png\" alt=\"14.5.7 Symptoms of Anemia\" width=\"623\" height=\"587\"><figcaption id=\"caption-attachment-4502\" class=\"wp-caption-text\"><em>Figure 14.5.8 Anemia has wide-ranging effects on the human body because oxygen is essential for normal functioning of cells in every organ system.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Feature: Myth vs. Reality<\/h1>\n<\/div>\n<p>Donating blood saves lives. In fact, with each blood donation, as many as <em>three<\/em> lives may be saved. According to Government Canada, up to 52% of Canadians have reported that they or a family member have needed blood or blood products at some point in their lifetime. Many donors agree that the\u00a0feeling that comes from knowing you have saved lives is well worth the short amount of time it takes to make a blood donation. Nonetheless, only a minority of potential donors actually donate blood. There are many myths about blood donation that may help explain the small percentage of donors. Knowing the facts may reaffirm your decision to donate if you are already a donor \u2014 and if you aren\u2019t a donor already, getting the facts may help you decide to become one.<\/p>\n<table class=\"grid\" style=\"border-collapse: collapse;width: 100%;height: 347px\" border=\"0\">\n<tbody>\n<tr>\n<th scope=\"col\"><span style=\"color: #ff0000\">Myth<\/span><\/th>\n<th scope=\"col\"><span style=\"color: #008000\">Reality<\/span><\/th>\n<\/tr>\n<tr style=\"height: 47px\">\n<td>\"Your blood might become contaminated with an infection during the donation.\"<\/td>\n<td>There is no risk of contamination because only single-use, disposable catheters, tubing, and other equipment are used to collect blood for a donation.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"You are too old (or too young) to donate blood.\"<\/td>\n<td>There is no upper age limit on donating blood, as long as you are healthy. The minimum age\u00a0is 16 years.<\/td>\n<\/tr>\n<tr style=\"height: 47px\">\n<td>\"You can\u2019t donate blood if you have high blood pressure.\"<\/td>\n<td>As long as your\u00a0blood pressure\u00a0is below 180\/100 at the time of donation, you can give blood. Even if you take blood pressure medication to keep your blood pressure below this level, you can donate.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"You can\u2019t give blood if you have high cholesterol.\"<\/td>\n<td>Having high cholesterol does not affect your ability to donate blood. Taking cholesterol-lowering medication also does not disqualify you.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"You can\u2019t donate blood if you have had a flu shot.\"<\/td>\n<td>Having a flu shot has no effect on your ability to donate blood. You can even donate on the same day that you receive a flu shot.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"You can\u2019t donate blood if you take medication.\"<\/td>\n<td>As long as you are healthy, in most cases, taking medication does not preclude you from donating blood.<\/td>\n<\/tr>\n<tr style=\"height: 31px\">\n<td>\"Your blood isn\u2019t needed if it\u2019s a common blood type.\"<\/td>\n<td>All types of blood are in constant demand.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">14.5 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2702\">Blood<\/a> is a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4402\">fluid connective tissue<\/a> that circulates throughout the body in the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3835\">cardiovascular system<\/a>. Blood supplies tissues with oxygen and\u00a0nutrients\u00a0and removes their metabolic wastes. Blood helps defend the body from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3707\">pathogens<\/a>\u00a0and other threats, transports <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3569\">hormones<\/a> and other substances, and helps keep the body\u2019s <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4330\">pH<\/a> and temperature in homeostasis.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4395\">Plasma<\/a> is the liquid component of blood, and it makes up more than half of blood by volume. It consists of water and many dissolved substances. It also contains blood cells, including erythrocytes, leukocytes and thrombocytes.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4398\">Erythrocytes<\/a>, (also known as red blood cells) are the most numerous cells in blood. They consist mostly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3556\">hemoglobin<\/a>, which carries oxygen. Erythrocytes also carry <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2704\">antigens<\/a>\u00a0that determine <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2703\">blood type<\/a>.<\/li>\n<li>Leukocytes (also referred to as white blood cells) are less numerous than erythrocytes and are part of the body\u2019s immune system. There are several different types of leukocytes that differ in their specific immune functions. They protect the body from abnormal cells, microorganisms, and other harmful substances.<\/li>\n<li>Thrombocytes (also called platelets) are cell fragments that play important roles in blood clotting, or coagulation. They stick together at breaks in blood vessels to form a clot and stimulate the production of fibrin, which strengthens the clot.<\/li>\n<li>All blood cells form by proliferation of stem cells in red bone marrow in a process called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3961\">hematopoiesis<\/a>. When blood cells die, they are phagocytized by leukocytes and removed from the circulation.<\/li>\n<li>Disorders of the blood include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4498\">leukemia<\/a>, which is\u00a0cancer\u00a0of the bone-forming cells; <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4499\">hemophilia<\/a>, which is any of several genetic blood-clotting disorders; <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4500\">carbon monoxide poisoning<\/a>, which prevents erythrocytes from binding with oxygen and causes suffocation; <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4501\">HIV<\/a> infection, which destroys certain types of leukocytes and can cause <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3523\">AIDS<\/a>; and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3449\">anemia<\/a>, in which there are not enough erythrocytes to carry adequate oxygen to body tissues.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">14.5 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is blood? Why is blood considered a connective tissue?<\/li>\n<li>Identify four physiological roles of blood in the body.<\/li>\n<li>Describe plasma and its components.<\/li>\n<li>\n<div id=\"h5p-398\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-398\" class=\"h5p-iframe\" data-content-id=\"398\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"14.5 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">14.5 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/e-5wqwp64MM<\/p>\n<p style=\"text-align: center\">Joe Landolina: This gel can make you stop bleeding instantly, TED, 2014.<\/p>\n<p>https:\/\/youtu.be\/hgp8LtwFSBA<\/p>\n<p style=\"text-align: center\">Can Synthetic Blood Help The World's Blood Shortage? Science Plus, 2016.<\/p>\n<p>https:\/\/youtu.be\/1Qfmkd6C8u8<\/p>\n<p style=\"text-align: center\">How bones make blood - Melody Smith, TED-Ed, 2020.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 14.5.1<\/strong><\/p>\n<p><a href=\"http:\/\/pngimg.com\/download\/35873\" rel=\"cc:attributionURL\">vampire_PNG32<\/a> from <a href=\"http:\/\/pngimg.com\">pngimg.com<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\" rel=\"license\">CC BY-NC 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) license.<\/p>\n<p><strong>Figure 14.5.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blood-centrifugation-scheme.png\" rel=\"cc:attributionURL\">Blood-centrifugation-scheme<\/a> by <a class=\"extiw\" title=\"wikipedia:User:KnuteKnudsen\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:KnuteKnudsen\">KnuteKnudsen<\/a>\u00a0at\u00a0<a class=\"extiw\" title=\"wikipedia:\" href=\"https:\/\/en.wikipedia.org\/wiki\/\">English Wikipedia<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 14.5.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:SEM_blood_cells.jpg\" rel=\"cc:attributionURL\">SEM_blood_cells<\/a> by Bruce Wetzel and Harry Schaefer (Photographers)\/ <a href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=2129\">NCI AV-8202-3656<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/en:Public_domain).<\/p>\n<p><strong>Figure 14.5.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:ABO_blood_type.svg\" rel=\"cc:attributionURL\">ABO_blood_type.svg<\/a> by <a class=\"new\" title=\"User:InvictaHOG (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:InvictaHOG&amp;action=edit&amp;redlink=1\">InvictaHOG<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/en:Public_domain).<\/p>\n<p><strong>Figure 14.5.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blood_clot_in_scanning_electron_microscopy.jpg\" rel=\"cc:attributionURL\">Blood_clot_in_scanning_electron_microscopy<\/a> by Janice Carr from CDC\/ Public Health Image LIbrary <a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=7308\">(PHIL) ID #7308<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:Public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/en:Public_domain).<\/p>\n<p><strong>Figure 14.5.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0740_Platelets.png\" rel=\"cc:attributionURL\">Blausen_0740_Platelets<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> <span style=\"text-align: initial;font-size: 1em\">on Wikimedia Commons is used under a <a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong><br \/>\nFigure 14.5.7<\/strong><\/p>\n<p><a href=\"https:\/\/theawkwardstore.com\/products\/platelet-party-id-badge-reel\" rel=\"cc:attributionURL\">Platelet_Party_900x<\/a>\u00a0by Awkward Yeti (used with permission of the author) \u00a9\u00a0<a href=\"https:\/\/choosealicense.com\/no-license\/\" rel=\"license\">All Rights Reserved<\/a><\/p>\n<p><strong>Figure 14.5.8<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Symptoms_of_anemia.svg\" rel=\"cc:attributionURL\">Symptoms_of_anemia.svg<\/a> by <a class=\"extiw\" title=\"en:User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/en:public_domain).<\/p>\n<p><span style=\"font-size: 1.424em;font-weight: bold\"><br \/>\nReferences<\/span><\/p>\n<p class=\"hanging-indent\">Blausen.com Staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">Blood, organ and tissue donation. (2020, April 28). Government of Canada. https:\/\/www.canada.ca\/en\/public-health\/services\/healthy-living\/blood-organ-tissue-donation.html#a3<\/p>\n<p class=\"hanging-indent\">Canadian Blood Services. (n.d.). There is an immediate need for blood as demand is rising. https:\/\/www.blood.ca<\/p>\n<p class=\"hanging-indent\"><span style=\"text-align: initial;font-size: 1em\">Science Plus. (2016, March 2). Can synthetic blood help the world's blood shortage? <\/span><span style=\"text-align: initial;font-size: 1em\">https:\/\/www.youtube.com\/watch?v=hgp8LtwFSBA&amp;feature=youtu.be<\/span><\/p>\n<p class=\"hanging-indent\">TED. (2014, November 20). Joe Landolina: This gel can make you stop bleeding instantly. YouTube. https:\/\/www.youtube.com\/watch?v=e-5wqwp64MM&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2020, January 27). How bones make blood - Melody Smith. YouTube. https:\/\/www.youtube.com\/watch?v=1Qfmkd6C8u8&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3124\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3124\"><div tabindex=\"-1\"><p>As per caption<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3125\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3125\"><div tabindex=\"-1\"><p>Image shows a diagram of the bladder. There is smooth muscle in the bladder walls which are under involuntary control.  There is a sphincter between the bladder and the urethra which can inhibit urination.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3126\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3126\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<div id=\"h5p-413\">\n<div class=\"h5p-content\" data-content-id=\"413\"><\/div>\n<\/div>\n<p><em>Figure 16.3.1 The surprising uses of pee.<\/em><\/p>\n<div>\n<h1>Surprising Uses<\/h1>\n<\/div>\n<p>What do gun powder, leather, fabric dyes and laundry service have in common?\u00a0 This may be surprising, but they all historically involved urine.\u00a0 One of the main components in gun powder, potassium nitrate, was difficult to come by pre-1900s, so ingenious gun-owners would evaporate urine to concentrate the nitrates it contains.\u00a0 The ammonium in urine was excellent in breaking down tissues, making it a prime candidate for softening leathers and removing stains in laundry.\u00a0 Ammonia in urine also helps dyes penetrate fabrics, so it was used to make colours stay brighter for longer.<\/p>\n<div>\n<h1>What is the Urinary System?<\/h1>\n<\/div>\n<p>The actual human\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2914\">urinary system<\/a><\/strong>, also known as the renal system, is shown in Figure 16.3.2. The system consists of the kidneys, ureters, bladder, and urethra. The main function of the urinary system is to eliminate the waste products of metabolism from the body by forming and excreting <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>.<\/strong> Typically, between one and two litres of urine are produced every day in a healthy individual.<\/p>\n<figure id=\"attachment_4722\" aria-describedby=\"caption-attachment-4722\" style=\"width: 560px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4722\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Urinary_System_Male-1.png\" alt=\"16.3.2 Urinary System\" width=\"560\" height=\"560\"><figcaption id=\"caption-attachment-4722\" class=\"wp-caption-text\"><em>16.3.2 The components of the urinary system include the two kidneys, two ureters, bladder, and urethra. The urinary system is the same in males and females, except the urethra is longer in males.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Organs of the Urinary System<\/h1>\n<\/div>\n<p>The urinary system is all about urine. It includes organs that form urine, and also those that transport, store, or excrete urine.<\/p>\n<h2>Kidneys<\/h2>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">Urine<\/a> is formed by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a>, which filter many substances out of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2702\">blood<\/a>, allow the blood to reabsorb needed materials, and use the remaining materials to form urine. The human body normally has two paired kidneys, although it is possible to get by quite well with just one. As you can see in Figure 16.3.3, each kidney is well supplied with blood vessels by a major artery and vein. Blood to be filtered enters the kidney through the renal artery, and the filtered blood leaves the kidney through the renal vein. The kidney itself is wrapped in a fibrous capsule, and consists of a thin outer layer called the cortex, and a thicker inner layer called the medulla.<\/p>\n<figure id=\"attachment_4723\" aria-describedby=\"caption-attachment-4723\" style=\"width: 1024px\" class=\"wp-caption alignnone\"><img class=\"size-full wp-image-4723\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2610_The_Kidney-1.jpg\" alt=\"16.3.3 The Kidney\" width=\"1024\" height=\"585\"><figcaption id=\"caption-attachment-4723\" class=\"wp-caption-text\"><em>Figure 16.3.3 The structure of the kidney is specialized to filter blood and form and collect urine.<\/em><\/figcaption><\/figure>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2702\">Blood<\/a> is filtered and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a> is formed by tiny filtering units called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephron<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. Each kidney contains at least a million nephrons, and each nephron spans the cortex and medulla layers of the kidney. After urine forms in the nephrons, it flows through a system of converging collecting ducts. The collecting ducts join together to form minor calyces (or chambers) that join together to form major calyces (see Figure 16.3.3 above). Ultimately, the major calyces join the <\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">, which is the funnel-like end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureter<\/a> where it enters the kidney.<\/span><\/p>\n<h2>Ureters, Bladder, Urethra<\/h2>\n<p>After urine forms in the kidneys, it is transported through the ureters (one per kidney) via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a> to the sac-like urinary bladder, which stores the urine until <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4726\">urination<\/a>. <\/strong>During urination, the urine is released from the bladder and transported by the urethra to be excreted outside the body through the external urethral opening.<\/p>\n<div>\n<h1>Functions of the Urinary System<\/h1>\n<\/div>\n<p>Waste products removed from the body with the formation and elimination of urine include many water-soluble metabolic products. The main waste products are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a> \u2014 a by-product of\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3721\">protein<\/a>\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3629\">catabolism<\/a> \u2014 and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4709\">uric\u00a0acid<\/a>, a by-product of\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4727\">nucleic acid<\/a>\u00a0catabolism. Excess\u00a0water\u00a0and mineral ions are also eliminated in urine.<\/p>\n<p>Besides the elimination of waste products such as these, the urinary system has several other vital functions. These include:<\/p>\n<ul>\n<li><strong>Maintaining<\/strong><strong>\u00a0homeostasis\u00a0of mineral ions in extracellular fluid<\/strong>: These ions are either excreted in urine or returned to the blood as needed to maintain the proper balance.<\/li>\n<li><strong>Maintaining homeostasis of blood pH<\/strong>:\u00a0When\u00a0pH\u00a0is too low (blood is too acidic), for example, the kidneys excrete less bicarbonate (which is basic) in urine. When pH is too high (blood is too basic), the opposite occurs, and more bicarbonate is excreted in urine.<\/li>\n<li><strong>Maintaining homeostasis of extracellular fluids, including the blood volume, which helps maintain<\/strong><strong>\u00a0blood pressure:<\/strong>\u00a0The kidneys control fluid volume and\u00a0blood pressure\u00a0by excreting more or less salt and\u00a0water\u00a0in urine.<\/li>\n<\/ul>\n<div>\n<h1>Control of the Urinary System<\/h1>\n<\/div>\n<p>The formation of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a> must be closely regulated to maintain body-wide\u00a0homeostasis. Several\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3893\">endocrine<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3569\">hormones<\/a>\u00a0help control this function of the urinary system, including antidiuretic\u00a0hormone, parathyroid hormone, and aldosterone.<\/p>\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3441\"><strong>Antidiuretic<\/strong><strong> hormone<\/strong><\/a><strong> (ADH)<\/strong>, also called vasopressin, is secreted by the\u00a0posterior\u00a0pituitary gland. One of its main roles is conserving body\u00a0water. It is released when the body is dehydrated, and it causes the kidneys to excrete less water in urine.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3467\"><strong>Parathyroid<\/strong><strong>\u00a0hormone<\/strong><\/a>\u00a0is secreted by the parathyroid glands. It works to regulate the balance of mineral ions in the body\u00a0via\u00a0its effects on several organs, including the kidneys. Parathyroid hormone stimulates the kidneys to excrete less calcium and more phosphorus in urine.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3789\">Aldosterone<\/a><\/strong> is secreted by the cortex of the adrenal glands, which rest atop the kidneys, as shown in Figure 16.3.4. Through its effect on the kidneys, it plays a central role in regulating blood pressure. It causes the kidneys to excrete less sodium and water in urine.<\/li>\n<\/ul>\n<figure id=\"attachment_4729\" aria-describedby=\"caption-attachment-4729\" style=\"width: 588px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4729 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Adrenal-glands-on-Kidney-by-NCI-Public-Domain-e1592620428819-1.jpg\" alt=\"16.3.4 Adrenal Glands\" width=\"588\" height=\"540\"><figcaption id=\"caption-attachment-4729\" class=\"wp-caption-text\"><em>Figure 16.3.4 The adrenal glands are located on top of the kidneys. They secrete aldosterone into the bloodstream, which carries it to the kidneys.<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_4730\" aria-describedby=\"caption-attachment-4730\" style=\"width: 428px\" class=\"wp-caption alignleft\"><img class=\" wp-image-4730\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Urinary_Sphincter-1.png\" alt=\"16.3.5 Urinary sphincter\" width=\"428\" height=\"428\"><figcaption id=\"caption-attachment-4730\" class=\"wp-caption-text\"><em>Figure 16.3.5 The urinary sphincter relaxes to allow urination.<\/em><\/figcaption><\/figure>\n<p>Once urine forms, it is excreted from the body in the process of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4726\">urination<\/a>, also sometimes referred to as micturition. This process is controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3807\">autonomic<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3014\">somatic<\/a> nervous systems. As the bladder fills with urine, it causes the autonomic nervous system to signal smooth muscle in the bladder wall to contract (as shown in Figure 16.3.5), and the sphincter between the bladder and urethra to relax and open. This forces urine out of the bladder and through the urethra. Another sphincter at the distal end of the urethra is under <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3004\">voluntary<\/a> control. When it relaxes under the influence of the somatic nervous system, it allows urine to leave the body through the external urethral opening.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2914\">urinary system<\/a> consists of the kidneys, ureters, bladder, and urethra. The main function of the urinary system is to eliminate the waste products of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3681\">metabolism<\/a> from the body by forming and excreting <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>.<\/li>\n<li>Urine is formed by the kidneys, which filter many substances out of blood, allow the blood to reabsorb needed materials, and use the remaining materials to form urine. Blood to be filtered enters the kidney through the renal artery, and filtered blood leaves the kidney through the renal vein.<\/li>\n<li>Within each <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidney<\/a>, blood is filtered and urine is formed by tiny filtering units called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephrons<\/a>, of which there are at least a million in each kidney.<\/li>\n<li>After urine forms in the kidneys, it is transported through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureters<\/a> via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a> to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a>. The bladder stores the urine until <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4726\">urination<\/a>, when urine is transported by the urethra to be excreted outside the body.<\/li>\n<li>Besides the elimination of waste products (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4709\">uric\u00a0acid<\/a>, excess water, and mineral ions), the urinary system has other vital functions. These include maintaining\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3669\">homeostasis<\/a>\u00a0of mineral ions in extracellular fluid, regulating acid-base\u00a0balance in the blood, regulating the volume of extracellular fluids, and controlling <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4480\">blood pressure<\/a>.<\/li>\n<li>The formation of urine must be closely regulated to maintain body-wide homeostasis. Several\u00a0endocrine hormones\u00a0help control this function of the urinary system, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3801\">antidiuretic hormone<\/a> from the\u00a0posterior\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2938\">pituitary gland<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3467\">parathyroid hormone<\/a> from the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3402\">parathyroid glands<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3789\">aldosterone<\/a> from the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3777\">adrenal glands<\/a>.<\/li>\n<li>The process of urination is controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3807\">autonomic<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3014\">somatic<\/a> nervous systems. The autonomic system causes the bladder to empty, but conscious relaxation of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4627\">sphincter<\/a> at the distal end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4732\">urethra<\/a> allows urine to leave the body.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-414\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-414\" class=\"h5p-iframe\" data-content-id=\"414\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"16.3 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>State the main function of the urinary system.<\/li>\n<li>What are nephrons?<\/li>\n<li>Other than the elimination of waste products, identify functions of the urinary system.<\/li>\n<li>How is the formation of urine regulated?<\/li>\n<li>Explain why it is important to have voluntary control over the sphincter at the end of the urethra.<\/li>\n<li>In terms of how they affect the kidneys, compare aldosterone to antidiuretic hormone.<\/li>\n<li>If your body needed to retain more calcium, which of the hormones described in this concept is most likely to increase? Explain your reasoning.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/dxecGD0m0Xc<\/p>\n<p style=\"text-align: center\">The Urinary System - An Introduction | Physiology | Biology | FuseSchool, 2017.<\/p>\n<p>https:\/\/youtu.be\/pyMcTUQYMQw<\/p>\n<p style=\"text-align: center\">Maple Syrup Urine Disease, Alexandria Doody, 2016.<\/p>\n<p>https:\/\/youtu.be\/3z-xjfdJWAI<\/p>\n<p style=\"text-align: center\">How Accurate Are Drug Tests? Seeker, 2016.<\/p>\n<p>https:\/\/youtu.be\/xt1Tj5eeS0k<\/p>\n<p style=\"text-align: center\">Three Ways Pee Could Change the World, Gross Science, 2015.<\/p>\n<\/div>\n<\/div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Attributions<\/span><\/p>\n<\/div>\n<p><strong>Figure 16.3.1<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Pyrodex_powder_ffg.jpg\">File:Pyrodex powder ffg.jpg<\/a> by <a title=\"User:Hustvedt\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Hustvedt\">Hustvedt<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/pFLNV4gkXsc\">Brown leather satchel bag<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@alvaroserrano\">\u00c1lvaro Serrano<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash Licence<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/nHhGuO-2YPw\">Laundry basket<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@andyfitz\">Andy Fitzsimon<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash Licence<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/pixabay.com\/photos\/wool-skeins-natural-dyed-colorful-593794\/\">Tags: Wool Skeins Natural Dyed Colorful Himalayan Weavers<\/a> by\u00a0 on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/li>\n<\/ul>\n<p><strong>Figure 16.3.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Urinary_System_(Male).png\" rel=\"cc:attributionURL\">Urinary_System_(Male)<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.3.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2610_The_Kidney.jpg\" rel=\"cc:attributionURL\">2610_The_Kidney<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.3.4<\/strong><\/p>\n<p><a href=\"https:\/\/visuals.nci.nih.gov\/details.cfm?imageid=4355\" rel=\"cc:attributionURL\">Adrenal glands on Kidney<\/a>\u00a0 by <a href=\"https:\/\/visuals.nci.nih.gov\/details.cfm?imageid=4355\">Alan Hoofring (Illustrator)\/ NCI Visuals Online<\/a> is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.3.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Urinary_Sphincter.png\" rel=\"cc:attributionURL\">Urinary_Sphincter<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Alexandria Doody. (2016, March 29). Maple syrup urine disease. YouTube. https:\/\/www.youtube.com\/watch?v=pyMcTUQYMQw&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><span class=\"os-number\">25.8<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"3662\" class=\"os-title\" data-type=\"title\">Left kidney [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 25.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney<\/span><\/p>\n<p class=\"hanging-indent\">FuseSchool. (2017, June 19). The urinary system - An introduction | Physiology | Biology | FuseSchool. YouTube. https:\/\/www.youtube.com\/watch?v=dxecGD0m0Xc&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Gross Science. (2015, September 15). Three ways pee could change the world. YouTube. https:\/\/www.youtube.com\/watch?v=xt1Tj5eeS0k&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Seeker. (2016, January 16). How accurate are drug tests? YouTube. https:\/\/www.youtube.com\/watch?v=3z-xjfdJWAI&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3127\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3127\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<div id=\"h5p-193\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-193\" class=\"h5p-iframe\" data-content-id=\"193\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"11.2 Quiz\"><\/iframe><\/div>\n<\/div>\n<p><em>Figure 16.3.1 The surprising uses of pee.<\/em><\/p>\n<div>\n<h1>Surprising Uses<\/h1>\n<\/div>\n<p>What do gun powder, leather, fabric dyes and laundry service have in common?\u00a0 This may be surprising, but they all historically involved urine.\u00a0 One of the main components in gun powder, potassium nitrate, was difficult to come by pre-1900s, so ingenious gun-owners would evaporate urine to concentrate the nitrates it contains.\u00a0 The ammonium in urine was excellent in breaking down tissues, making it a prime candidate for softening leathers and removing stains in laundry.\u00a0 Ammonia in urine also helps dyes penetrate fabrics, so it was used to make colours stay brighter for longer.<\/p>\n<div>\n<h1>What is the Urinary System?<\/h1>\n<\/div>\n<p>The actual human\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2914\">urinary system<\/a><\/strong>, also known as the renal system, is shown in Figure 16.3.2. The system consists of the kidneys, ureters, bladder, and urethra. The main function of the urinary system is to eliminate the waste products of metabolism from the body by forming and excreting <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>.<\/strong> Typically, between one and two litres of urine are produced every day in a healthy individual.<\/p>\n<figure id=\"attachment_4722\" aria-describedby=\"caption-attachment-4722\" style=\"width: 560px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4722\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Urinary_System_Male-1.png\" alt=\"16.3.2 Urinary System\" width=\"560\" height=\"560\"><figcaption id=\"caption-attachment-4722\" class=\"wp-caption-text\"><em>16.3.2 The components of the urinary system include the two kidneys, two ureters, bladder, and urethra. The urinary system is the same in males and females, except the urethra is longer in males.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Organs of the Urinary System<\/h1>\n<\/div>\n<p>The urinary system is all about urine. It includes organs that form urine, and also those that transport, store, or excrete urine.<\/p>\n<h2>Kidneys<\/h2>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">Urine<\/a> is formed by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a>, which filter many substances out of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2702\">blood<\/a>, allow the blood to reabsorb needed materials, and use the remaining materials to form urine. The human body normally has two paired kidneys, although it is possible to get by quite well with just one. As you can see in Figure 16.3.3, each kidney is well supplied with blood vessels by a major artery and vein. Blood to be filtered enters the kidney through the renal artery, and the filtered blood leaves the kidney through the renal vein. The kidney itself is wrapped in a fibrous capsule, and consists of a thin outer layer called the cortex, and a thicker inner layer called the medulla.<\/p>\n<figure id=\"attachment_4723\" aria-describedby=\"caption-attachment-4723\" style=\"width: 1024px\" class=\"wp-caption alignnone\"><img class=\"size-full wp-image-4723\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2610_The_Kidney-1.jpg\" alt=\"16.3.3 The Kidney\" width=\"1024\" height=\"585\"><figcaption id=\"caption-attachment-4723\" class=\"wp-caption-text\"><em>Figure 16.3.3 The structure of the kidney is specialized to filter blood and form and collect urine.<\/em><\/figcaption><\/figure>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2702\">Blood<\/a> is filtered and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a> is formed by tiny filtering units called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephron<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. Each kidney contains at least a million nephrons, and each nephron spans the cortex and medulla layers of the kidney. After urine forms in the nephrons, it flows through a system of converging collecting ducts. The collecting ducts join together to form minor calyces (or chambers) that join together to form major calyces (see Figure 16.3.3 above). Ultimately, the major calyces join the <\/span><strong style=\"text-align: initial;font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a><\/strong><span style=\"text-align: initial;font-size: 1em\">, which is the funnel-like end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureter<\/a> where it enters the kidney.<\/span><\/p>\n<h2>Ureters, Bladder, Urethra<\/h2>\n<p>After urine forms in the kidneys, it is transported through the ureters (one per kidney) via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a> to the sac-like urinary bladder, which stores the urine until <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4726\">urination<\/a>. <\/strong>During urination, the urine is released from the bladder and transported by the urethra to be excreted outside the body through the external urethral opening.<\/p>\n<div>\n<h1>Functions of the Urinary System<\/h1>\n<\/div>\n<p>Waste products removed from the body with the formation and elimination of urine include many water-soluble metabolic products. The main waste products are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a> \u2014 a by-product of\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_297\">protein<\/a>\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_178\">catabolism<\/a> \u2014 and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4709\">uric\u00a0acid<\/a>, a by-product of\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4727\">nucleic acid<\/a>\u00a0catabolism. Excess\u00a0water\u00a0and mineral ions are also eliminated in urine.<\/p>\n<p>Besides the elimination of waste products such as these, the urinary system has several other vital functions. These include:<\/p>\n<ul>\n<li><strong>Maintaining<\/strong><strong>\u00a0homeostasis\u00a0of mineral ions in extracellular fluid<\/strong>: These ions are either excreted in urine or returned to the blood as needed to maintain the proper balance.<\/li>\n<li><strong>Maintaining homeostasis of blood pH<\/strong>:\u00a0When\u00a0pH\u00a0is too low (blood is too acidic), for example, the kidneys excrete less bicarbonate (which is basic) in urine. When pH is too high (blood is too basic), the opposite occurs, and more bicarbonate is excreted in urine.<\/li>\n<li><strong>Maintaining homeostasis of extracellular fluids, including the blood volume, which helps maintain<\/strong><strong>\u00a0blood pressure:<\/strong>\u00a0The kidneys control fluid volume and\u00a0blood pressure\u00a0by excreting more or less salt and\u00a0water\u00a0in urine.<\/li>\n<\/ul>\n<div>\n<h1>Control of the Urinary System<\/h1>\n<\/div>\n<p>The formation of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a> must be closely regulated to maintain body-wide\u00a0homeostasis. Several\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2909\">endocrine<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_377\">hormones<\/a>\u00a0help control this function of the urinary system, including antidiuretic\u00a0hormone, parathyroid hormone, and aldosterone.<\/p>\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4728\"><strong>Antidiuretic<\/strong><strong> hormone<\/strong><\/a><strong> (ADH)<\/strong>, also called vasopressin, is secreted by the\u00a0posterior\u00a0pituitary gland. One of its main roles is conserving body\u00a0water. It is released when the body is dehydrated, and it causes the kidneys to excrete less water in urine.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3467\"><strong>Parathyroid<\/strong><strong>\u00a0hormone<\/strong><\/a>\u00a0is secreted by the parathyroid glands. It works to regulate the balance of mineral ions in the body\u00a0via\u00a0its effects on several organs, including the kidneys. Parathyroid hormone stimulates the kidneys to excrete less calcium and more phosphorus in urine.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3406\">Aldosterone<\/a><\/strong> is secreted by the cortex of the adrenal glands, which rest atop the kidneys, as shown in Figure 16.3.4. Through its effect on the kidneys, it plays a central role in regulating blood pressure. It causes the kidneys to excrete less sodium and water in urine.<\/li>\n<\/ul>\n<figure id=\"attachment_4729\" aria-describedby=\"caption-attachment-4729\" style=\"width: 588px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4729 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Adrenal-glands-on-Kidney-by-NCI-Public-Domain-e1592620428819-1.jpg\" alt=\"16.3.4 Adrenal Glands\" width=\"588\" height=\"540\"><figcaption id=\"caption-attachment-4729\" class=\"wp-caption-text\"><em>Figure 16.3.4 The adrenal glands are located on top of the kidneys. They secrete aldosterone into the bloodstream, which carries it to the kidneys.<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_4730\" aria-describedby=\"caption-attachment-4730\" style=\"width: 428px\" class=\"wp-caption alignleft\"><img class=\" wp-image-4730\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Urinary_Sphincter-1.png\" alt=\"16.3.5 Urinary sphincter\" width=\"428\" height=\"428\"><figcaption id=\"caption-attachment-4730\" class=\"wp-caption-text\"><em>Figure 16.3.5 The urinary sphincter relaxes to allow urination.<\/em><\/figcaption><\/figure>\n<p>Once urine forms, it is excreted from the body in the process of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4726\">urination<\/a>, also sometimes referred to as micturition. This process is controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2940\">autonomic<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3014\">somatic<\/a> nervous systems. As the bladder fills with urine, it causes the autonomic nervous system to signal smooth muscle in the bladder wall to contract (as shown in Figure 16.3.5), and the sphincter between the bladder and urethra to relax and open. This forces urine out of the bladder and through the urethra. Another sphincter at the distal end of the urethra is under <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3004\">voluntary<\/a> control. When it relaxes under the influence of the somatic nervous system, it allows urine to leave the body through the external urethral opening.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2914\">urinary system<\/a> consists of the kidneys, ureters, bladder, and urethra. The main function of the urinary system is to eliminate the waste products of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_176\">metabolism<\/a> from the body by forming and excreting <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>.<\/li>\n<li>Urine is formed by the kidneys, which filter many substances out of blood, allow the blood to reabsorb needed materials, and use the remaining materials to form urine. Blood to be filtered enters the kidney through the renal artery, and filtered blood leaves the kidney through the renal vein.<\/li>\n<li>Within each <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidney<\/a>, blood is filtered and urine is formed by tiny filtering units called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephrons<\/a>, of which there are at least a million in each kidney.<\/li>\n<li>After urine forms in the kidneys, it is transported through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureters<\/a> via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a> to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a>. The bladder stores the urine until <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4726\">urination<\/a>, when urine is transported by the urethra to be excreted outside the body.<\/li>\n<li>Besides the elimination of waste products (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4709\">uric\u00a0acid<\/a>, excess water, and mineral ions), the urinary system has other vital functions. These include maintaining\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a>\u00a0of mineral ions in extracellular fluid, regulating acid-base\u00a0balance in the blood, regulating the volume of extracellular fluids, and controlling <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4480\">blood pressure<\/a>.<\/li>\n<li>The formation of urine must be closely regulated to maintain body-wide homeostasis. Several\u00a0endocrine hormones\u00a0help control this function of the urinary system, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3094\">antidiuretic hormone<\/a> from the\u00a0posterior\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2938\">pituitary gland<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3467\">parathyroid hormone<\/a> from the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3402\">parathyroid glands<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3406\">aldosterone<\/a> from the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2959\">adrenal glands<\/a>.<\/li>\n<li>The process of urination is controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2940\">autonomic<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3014\">somatic<\/a> nervous systems. The autonomic system causes the bladder to empty, but conscious relaxation of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4627\">sphincter<\/a> at the distal end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4732\">urethra<\/a> allows urine to leave the body.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-194\">\n<div class=\"h5p-content\" data-content-id=\"194\"><\/div>\n<\/div>\n<\/li>\n<li>State the main function of the urinary system.<\/li>\n<li>What are nephrons?<\/li>\n<li>Other than the elimination of waste products, identify functions of the urinary system.<\/li>\n<li>How is the formation of urine regulated?<\/li>\n<li>Explain why it is important to have voluntary control over the sphincter at the end of the urethra.<\/li>\n<li>In terms of how they affect the kidneys, compare aldosterone to antidiuretic hormone.<\/li>\n<li>If your body needed to retain more calcium, which of the hormones described in this concept is most likely to increase? Explain your reasoning.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.3 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/dxecGD0m0Xc<\/p>\n<p style=\"text-align: center\">The Urinary System - An Introduction | Physiology | Biology | FuseSchool, 2017.<\/p>\n<p>https:\/\/youtu.be\/pyMcTUQYMQw<\/p>\n<p style=\"text-align: center\">Maple Syrup Urine Disease, Alexandria Doody, 2016.<\/p>\n<p>https:\/\/youtu.be\/3z-xjfdJWAI<\/p>\n<p style=\"text-align: center\">How Accurate Are Drug Tests? Seeker, 2016.<\/p>\n<p>https:\/\/youtu.be\/xt1Tj5eeS0k<\/p>\n<p style=\"text-align: center\">Three Ways Pee Could Change the World, Gross Science, 2015.<\/p>\n<\/div>\n<\/div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Attributions<\/span><\/p>\n<\/div>\n<p><strong>Figure 16.3.1<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Pyrodex_powder_ffg.jpg\">File:Pyrodex powder ffg.jpg<\/a> by <a title=\"User:Hustvedt\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Hustvedt\">Hustvedt<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/pFLNV4gkXsc\">Brown leather satchel bag<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@alvaroserrano\">\u00c1lvaro Serrano<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash Licence<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/nHhGuO-2YPw\">Laundry basket<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@andyfitz\">Andy Fitzsimon<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash Licence<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/pixabay.com\/photos\/wool-skeins-natural-dyed-colorful-593794\/\">Tags: Wool Skeins Natural Dyed Colorful Himalayan Weavers<\/a> by\u00a0 on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/li>\n<\/ul>\n<p><strong>Figure 16.3.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Urinary_System_(Male).png\" rel=\"cc:attributionURL\">Urinary_System_(Male)<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.3.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2610_The_Kidney.jpg\" rel=\"cc:attributionURL\">2610_The_Kidney<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.3.4<\/strong><\/p>\n<p><a href=\"https:\/\/visuals.nci.nih.gov\/details.cfm?imageid=4355\" rel=\"cc:attributionURL\">Adrenal glands on Kidney<\/a>\u00a0 by <a href=\"https:\/\/visuals.nci.nih.gov\/details.cfm?imageid=4355\">Alan Hoofring (Illustrator)\/ NCI Visuals Online<\/a> is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.3.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Urinary_Sphincter.png\" rel=\"cc:attributionURL\">Urinary_Sphincter<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Alexandria Doody. (2016, March 29). Maple syrup urine disease. YouTube. https:\/\/www.youtube.com\/watch?v=pyMcTUQYMQw&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><span class=\"os-number\">25.8<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"3662\" class=\"os-title\" data-type=\"title\">Left kidney [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 25.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney<\/span><\/p>\n<p class=\"hanging-indent\">FuseSchool. (2017, June 19). The urinary system - An introduction | Physiology | Biology | FuseSchool. YouTube. https:\/\/www.youtube.com\/watch?v=dxecGD0m0Xc&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Gross Science. (2015, September 15). Three ways pee could change the world. YouTube. https:\/\/www.youtube.com\/watch?v=xt1Tj5eeS0k&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Seeker. (2016, January 16). How accurate are drug tests? YouTube. https:\/\/www.youtube.com\/watch?v=3z-xjfdJWAI&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3128\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3128\"><div tabindex=\"-1\"><p>Image shows a freshly baked Steak and Kidney Pie.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3129\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3129\"><div tabindex=\"-1\"><p>Image shows a labelled diagram of the posterior (from the back) view of the kidneys.  The aorta and renal arteries are clearly visible bringing blood to each kidney.  The left kidney sits a bit higher than the right kidney.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_5953\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_5953\"><div tabindex=\"-1\"><p>The transparent front part of the eye that covers the iris, pupil, and anterior chamber.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3134\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3134\"><div tabindex=\"-1\"><p>Image shows a diagram of a renal tubule and which substances are secreted or absorbed at each location along the tubule.  Most secretion happens at the proximal convoluted tubule, although it does take place at all locations on the renal tubule.  Reabsorption  occurs mainly in the loop of Henle when balancing water and in the distal convoluted tubule when balancing pH.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3135\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3135\"><div tabindex=\"-1\"><p>As per caption<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_5895\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_5895\"><div tabindex=\"-1\"><p>A\u00a0transparent watery fluid similar to plasma, but containing low protein concentrations. It is secreted from the ciliary\u00a0epithelium, a structure supporting the lens.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3137\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3137\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4736\" aria-describedby=\"caption-attachment-4736\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4736\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Steak-and-Kidney-Pie-by-Charles-Haynes-on-flickr-1.jpg\" alt=\"16.4.1 Kidney Pie\" width=\"400\" height=\"356\"><figcaption id=\"caption-attachment-4736\" class=\"wp-caption-text\"><em>Figure 16.4.1 Steak and kidney pie!<\/em><\/figcaption><\/figure>\n<div>\n<h1>Kidneys on the Menu<\/h1>\n<\/div>\n<p>Pictured in Figure 16.4.1 is a steak and kidney pie; this savory dish is a British favorite. When kidneys are on a menu, they typically come from sheep, pigs, or cows. In these animals (as in the human animal), kidneys are the main organs of excretion.<\/p>\n<div>\n<h1>Location\u00a0of the Kidneys<\/h1>\n<\/div>\n<p>The two bean-shaped\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a><\/strong>\u00a0are located high in the back of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3763\">abdominal cavity<\/a>, one on each side of the spine. Both kidneys sit just below the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4292\">diaphragm<\/a>, the large\u00a0breathing\u00a0muscle that separates the abdominal and thoracic cavities. As you can see in the\u00a0following\u00a0figure, the right kidney is slightly smaller and lower than the left kidney. The right kidney is behind the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2989\">liver<\/a>, and the left kidney is behind the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4497\">spleen<\/a>. The\u00a0location\u00a0of the liver explains why the right kidney is smaller and lower than the left.<\/p>\n<figure id=\"attachment_4737\" aria-describedby=\"caption-attachment-4737\" style=\"width: 455px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4737\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Gray-Kidneys-1.png\" alt=\"16.4.2 Classic Kidney Illustration from Gray's Anatomy\" width=\"455\" height=\"600\"><figcaption id=\"caption-attachment-4737\" class=\"wp-caption-text\"><em>Figure 16.4.2 This classic illustration of the abdominal cavity provides a view of the internal organs from the back of the body. It clearly shows the locations of the right and left kidney, as well as the large blood vessels that connect the kidneys to the body\u2019s main artery (aorta) and vein (inferior vena cava). The ureter exiting each kidney is also shown in the diagram.<\/em><\/figcaption><\/figure>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Kidney Anatomy<\/span><\/p>\n<p>The shape of each kidney gives it a convex side (curving outward) and a concave side (curving inward). You can see this clearly in the detailed diagram of kidney anatomy shown in Figure 16.4.3. The concave side is where the renal artery enters the kidney, as well as where the renal vein and ureter leave the kidney. This area of the kidney is called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4739\">hilum<\/a><\/strong>. The entire kidney is surrounded by tough fibrous tissue \u2014 called the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4740\">renal capsule<\/a><\/strong>\u00a0\u2014 which, in turn, is surrounded by two layers of protective, cushioning fat.<\/p>\n<figure id=\"attachment_4738\" aria-describedby=\"caption-attachment-4738\" style=\"width: 765px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4738\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0592_KidneyAnatomy_01-1.png\" alt=\"16.4.3 Kidney Anatomy\" width=\"765\" height=\"574\"><figcaption id=\"caption-attachment-4738\" class=\"wp-caption-text\"><em>Figure 16.4.3 This diagram shows the location and relative size of the two kidneys, as well as the internal structure of each kidney.<\/em><\/figcaption><\/figure>\n<p>Internally, each kidney is divided into two major layers: the outer <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4741\"><strong>renal cortex<\/strong><\/a> and the inner <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4742\"><strong>renal medulla<\/strong><\/a> (see Figure 16.4.3 above). These layers take the shape of many cone-shaped renal lobules, each containing renal cortex surrounding a portion of medulla called a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4743\"><strong>renal pyramid<\/strong><\/a>. Within the renal pyramids are the structural and functional units of the kidneys, the tiny <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephron<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. Between the renal pyramids are projections of cortex called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4744\"><strong>renal columns<\/strong><\/a>. The tip, or papilla, of each pyramid empties urine into a minor calyx (chamber). Several minor calyces empty into a major calyx, and the latter empty into the funnel-shaped cavity called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a>, which becomes the ureter as it leaves the kidney.<\/span><\/p>\n<div>\n<h3>Renal\u00a0Circulation<\/h3>\n<\/div>\n<p>The renal circulation is an important part of the kidney\u2019s primary function of filtering waste products from the blood. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2702\">Blood<\/a> is supplied to the kidneys via the renal arteries. The right renal artery supplies the right kidney, and the left renal artery supplies the left kidney. These two arteries branch directly from the aorta, which is the largest artery in the body. Each kidney is only about 11 cm (4.4 in) long, and has a mass of just 150 grams (5.3 oz), yet it receives about ten per cent of the total output of blood from the heart. Blood is filtered through the kidneys every 3 minutes, 24 hours a day, every day of your life.<\/p>\n<p>As indicated in Figure 16.4.4, each renal artery carries blood with waste products into the kidney. Within the kidney, the renal artery branches into increasingly smaller <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4385\">arteries<\/a> that extend through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4744\">renal columns<\/a> between the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4743\">renal pyramids<\/a>. These arteries, in turn, branch into arterioles that penetrate the renal pyramids. Blood in the arterioles passes through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephrons<\/a>, the structures that actually filter the blood. After blood passes through the nephrons and is filtered, the clean blood moves through a network of venules that converge into small <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4386\">veins<\/a>. Small veins merge into increasingly larger ones, and ultimately into the renal vein, which carries clean blood away from the kidney to the inferior <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4410\">vena cava<\/a>.<\/p>\n<figure id=\"attachment_4745\" aria-describedby=\"caption-attachment-4745\" style=\"width: 683px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4745\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Diagram_showing_how_the_kidneys_work_CRUK_138.svg_-1.png\" alt=\"16.4.4 Kidney and Nephron\" width=\"683\" height=\"719\"><figcaption id=\"caption-attachment-4745\" class=\"wp-caption-text\"><em>Figure 16.4.4 The renal artery and renal vein carry blood to and from the kidney, respectively. As blood passes through a nephron within the kidney, it is filtered. Substances filtered from the blood are eventually collected in a tubule (collecting duct).<\/em><\/figcaption><\/figure>\n<div>\n<h1>Nephron Structure and Function<\/h1>\n<\/div>\n<p>Figure 16.4.4 gives an indication of the complex structure of a nephron. The <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephron<\/a><\/strong>\u00a0is the basic structural and functional unit of the kidney, and each kidney typically contains at least a million of them. As blood flows through a nephron, many materials are filtered out of the blood, needed materials are returned to the blood, and the remaining materials form urine. Most of the waste products removed from the blood and excreted in urine are byproducts of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3681\">metabolism<\/a>. At least half of the waste is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, a waste product produced by\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3721\">protein<\/a>\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3629\">catabolism<\/a>. Another important waste is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4709\">uric\u00a0acid<\/a>, produced in\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4727\">nucleic acid<\/a>\u00a0catabolism.<\/p>\n<h2>Components of a Nephron<\/h2>\n<p>Figure 16.4.5 shows in greater detail the components of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephron<\/a>. Each nephron is composed of an initial filtering component that consists of a network of capillaries called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4747\">glomerulus<\/a><\/strong>\u00a0(plural, glomeruli), which is surrounded by a space within a structure\u00a0called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4748\">glomerular capsule<\/a> <\/strong>(also known as the Bowman's capsule). Extending from glomerular capsule is the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4749\">renal tubule<\/a><\/strong>. The proximal end (nearest glomerular capsule) of the renal tubule is called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4750\">proximal convoluted (coiled) tubule<\/a><\/strong>. From here, the renal tubule continues as a loop (known as the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4751\"><strong>loop of Henle<\/strong><\/a>) (also known as the loop of the nephron), which in turn becomes the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4752\"><strong>distal convoluted tubule<\/strong><\/a>. The latter finally joins with a collecting duct. As you can see in the diagram, arterioles surround the total length of the renal tubule in a mesh called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4753\"><strong>peritubular capillary network<\/strong><\/a>.<\/p>\n<figure id=\"attachment_4746\" aria-describedby=\"caption-attachment-4746\" style=\"width: 425px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4746\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blood_Flow_in_the_Nephron-1.jpg\" alt=\"16.4.5 Nephron\" width=\"425\" height=\"600\"><figcaption id=\"caption-attachment-4746\" class=\"wp-caption-text\"><em>Figure 16.4.5 This model of an individual nephron shows each of the structures that are involved in filtering blood, returning needed materials to blood, or excreting wastes that form urine.<\/em><\/figcaption><\/figure>\n<div><\/div>\n<figure id=\"attachment_4754\" aria-describedby=\"caption-attachment-4754\" style=\"width: 257px\" class=\"wp-caption alignright\"><img class=\"size-medium wp-image-4754\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/1024px-Physiology_of_Nephron-1.png\" alt=\"16.4.6 Urine Formation at the Nephron\" width=\"257\" height=\"300\"><figcaption id=\"caption-attachment-4754\" class=\"wp-caption-text\">Figure 16.4.6 This diagram of a nephron shows the parts of the nephron where different stages of nephron function take place. These stages are filtration, reabsorption, secretion, and excretion.<\/figcaption><\/figure>\n<h2>Function of a Nephron<\/h2>\n<p>The simplified diagram of a nephron in Figure 16.4.6 shows an overview of how the nephron functions. Blood enters the nephron through an arteriole called the afferent arteriole. Next, some of the blood passes through the capillaries of the glomerulus. Any blood that doesn\u2019t pass through the glomerulus \u2014 as well as blood after it passes through the glomerular capillaries \u2014 continues on through an arteriole called the efferent arteriole. The efferent arteriole follows the renal tubule of the nephron, where it continues\u00a0playing a role\u00a0in nephron functioning.<\/p>\n<p>&nbsp;<\/p>\n<h3>Filtration<\/h3>\n<p>As blood from the afferent arteriole flows through the glomerular capillaries, it is under pressure. Because of the pressure, water and solutes are filtered out of the blood and into the space made by glomerular capsule, almost like the water you cook pasta is is filtered out through a strainer. This is the filtration stage of nephron function. The filtered substances \u2014 called <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3379\">filtrate<\/a><\/strong> \u2014 pass into glomerular capsule, and from there into the proximal end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4749\">renal tubule<\/a>.\u00a0 Anything too large to move through the pores in the glomerulus, such as blood cells, large proteins, etc., stay in the cardiovascular system.\u00a0 At this stage, filtrate (fluid in the nephron) includes water, salts, organic solids (such as nutrients), and waste products of metabolism (such as urea).<\/p>\n<figure id=\"attachment_4756\" aria-describedby=\"caption-attachment-4756\" style=\"width: 403px\" class=\"wp-caption alignright\"><img class=\" wp-image-4756\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nephron_Secretion_Reabsorption-1.jpg\" alt=\"16.4.7 Nephron Secretion and Reabsorption\" width=\"403\" height=\"769\"><figcaption id=\"caption-attachment-4756\" class=\"wp-caption-text\"><em>Figure 16.4.7 Secretion and reabsorption happen along the length of the renal tubule as the nephron balances blood pH and volume and maintains homeostasis of ions in the blood. Reabsorption is the movement of substance back into the bloodstream and secretion is movement of substances from the blood into the nephron for excretion.<\/em><\/figcaption><\/figure>\n<h3>Reabsorption and Secretion<\/h3>\n<p>As filtrate moves through the renal tubule, some of the substances it contains are reabsorbed from the filtrate back into the blood in the efferent arteriole (via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4753\">peritubular capillary network<\/a>). This is the reabsorption stage of nephron function and it is about returning \"the good stuff\" back to the blood so that it doesn't exit the body in urine. About two-thirds of the filtered salts and water, and all of the filtered organic solutes (mainly <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3359\">glucose<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3615\">amino acid<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">) are reabsorbed from the filtrate by the blood in the peritubular capillary network. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4757\">Reabsorption<\/a> occurs mainly in the proximal convoluted tubule and the loop of Henle, as seen in Figure 16.4.7.<\/span><\/p>\n<p>At the distal end of the renal tubule, some additional reabsorption generally occurs. This is also the region of the tubule where other substances from the blood are added to the filtrate in the tubule. The addition of other substances to the filtrate from the blood is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4758\">secretion<\/a><\/strong>. Both reabsorption and secretion (shown in Figure 16.4.7) in the distal convoluted tubule are largely under the control of endocrine hormones that maintain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3669\">homeostasis<\/a> of water and mineral salts in the blood. These hormones work by controlling what is reabsorbed into the blood from the filtrate and what is secreted from the blood into the filtrate to become urine. For example, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3467\">parathyroid hormone<\/a> causes more calcium to be reabsorbed into the blood and more phosphorus to be secreted into the filtrate.<\/p>\n<h2>Collection of Urine and Excretion<\/h2>\n<figure id=\"attachment_4760\" aria-describedby=\"caption-attachment-4760\" style=\"width: 219px\" class=\"wp-caption alignleft\"><img class=\" wp-image-4760\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Weewee-1.jpg\" alt=\"16.4.8 Urine\" width=\"219\" height=\"478\"><figcaption id=\"caption-attachment-4760\" class=\"wp-caption-text\"><em>Figure 16.4.8 Fresh urine is typically yellow or amber in colour.<\/em><\/figcaption><\/figure>\n<p>By the time the filtrate has passed through the entire renal tubule, it has become the\u00a0liquid\u00a0waste known as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>. Urine empties from the distal end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4749\">renal tubule<\/a> into a\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4759\">collecting duct<\/a><\/strong>. From there, the urine flows into increasingly larger collecting ducts. As urine flows through the system of collecting ducts, more water may be reabsorbed from it. This will occur in the presence of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3441\">antidiuretic\u00a0hormone\u00a0<\/a>from the\u00a0posterior\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2938\">pituitary gland<\/a>. This\u00a0hormone\u00a0makes the collecting ducts permeable to water, allowing water molecules to pass through them into capillaries by\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3571\">osmosis<\/a>, while preventing the passage of ions or other solutes. As much as 75% of the water may be reabsorbed from urine in the collecting ducts, making the urine more concentrated.<\/p>\n<p>Urine finally exits the largest collecting ducts through the renal papillae. It empties into the renal calyces, and finally into the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a>. From there, it travels through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureter<\/a> to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a> for eventual excretion from the body. An average of roughly 1.5 litres (a little over 6 cups) of urine is excreted each day. Normally, urine is yellow or amber in colour (see <span style=\"font-size: 1em\">Figure 16.4.8<\/span><span style=\"text-align: initial;font-size: 1em\">). The darker the colour, generally speaking, the more concentrated the urine is.<\/span><\/p>\n<p>&nbsp;<\/p>\n<div><span style=\"font-size: 1.602em;font-weight: bold\">Other Functions of the Kidneys<\/span><\/div>\n<p>Besides filtering blood and forming urine for excretion of soluble wastes, the kidneys have several vital functions in maintaining body-wide\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3669\">homeostasis<\/a>. Most of these functions are related to the\u00a0composition\u00a0or volume of urine formed by the kidneys. The kidneys must maintain the proper balance of water and salts in the body, normal\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4480\">blood pressure<\/a>, and the correct range of blood\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4330\">pH<\/a>. Through the processes of absorption and secretion by nephrons, more or less water, salt ions, acids, or bases are returned to the blood or excreted in urine, as needed, to maintain homeostasis.<\/p>\n<h2>Blood Pressure\u00a0Regulation<\/h2>\n<p>The kidneys do not control homeostasis all alone. As indicated above, endocrine hormones are also involved. Consider the regulation of\u00a0blood pressure\u00a0by the kidneys. Blood pressure is the pressure exerted by blood on the walls of the arteries. The regulation of blood pressure is part of a complex system, called the renin-angiotensin-aldosterone system. This system regulates the\u00a0concentration\u00a0of sodium in the blood to control blood pressure.<\/p>\n<figure id=\"attachment_4761\" aria-describedby=\"caption-attachment-4761\" style=\"width: 736px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4761\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Renin_Angiotensin_System-01-1.jpg\" alt=\"16.4.9 Regulation of Blood Pressure\" width=\"736\" height=\"336\"><figcaption id=\"caption-attachment-4761\" class=\"wp-caption-text\"><em>Figure 16.4.9 This diagram summarizes the processes that occur in the regulation of blood pressure by the renin-angiotensin-aldosterone system. The final step on the far right occurs in the nephrons and collecting ducts of the kidneys, where aldosterone stimulates increased reabsorption of sodium and water into the blood.<\/em><\/figcaption><\/figure>\n<p>The renin-angiotensin-aldosterone system is put into play when the\u00a0concentration\u00a0of sodium ions in the blood falls lower than normal. This causes the kidneys to secrete an\u00a0enzyme\u00a0called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4762\">renin<\/a> into the blood. It also causes the liver to secrete a\u00a0protein\u00a0called angiotensinogen. Renin changes angiotensinogen into a proto-hormone\u00a0called\u00a0angiotensin I. This is converted to angiotensin II by an\u00a0enzyme\u00a0(angiotensin-converting enzyme) in lung capillaries.<\/p>\n<p>Angiotensin II is a potent hormone that causes arterioles to constrict. This, in turn, increases blood pressure. Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex. Aldosterone causes the kidneys to increase the reabsorption of sodium ions and water from the filtrate into the blood. This returns the\u00a0concentration\u00a0of sodium ions in the blood to normal. The increased water in the blood also increases blood volume and blood pressure.<\/p>\n<h2>Other Kidney Hormones<\/h2>\n<p>Hormones other than renin are also produced and secreted by the kidneys. These include calcitriol and erythropoietin.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4763\">Calcitriol<\/a><\/strong>\u00a0is secreted by the kidneys in response to low levels of calcium in the blood. This hormone stimulates uptake of calcium by the intestine, thus raising blood levels of calcium.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4764\">Erythropoietin<\/a><\/strong> is secreted by the kidneys in response to low levels of oxygen in the blood. This hormone stimulates erythropoiesis, which is the production of\u00a0 <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4398\">erythrocytes<\/a>\u00a0in bone marrow. Extra red blood cells increase the level of oxygen carried in the blood.<\/li>\n<\/ul>\n<div>\n<h1>Feature: Human Biology in the News<\/h1>\n<\/div>\n<p>Kidney failure is a complication of common disorders including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2771\">diabetes mellitus<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4231\">hypertension<\/a>. It is estimated that approximately 12.5% of Canadians have some form of kidney disease.\u00a0 If the disease is serious, the patient must either receive a donated kidney or have frequent hemodialysis, a medical procedure in which the blood is artificially filtered through a machine. Transplant generally results in better outcomes than hemodialysis, but demand for organs far outstrips the supply. The average time on the organ donation waitlist for a kidney is four years.\u00a0 There are over 3,000 Canadians on the wait list for a kidney transplant and some will die waiting for a kidney to become available.<\/p>\n<p>For the past decade, Dr. William Fissell, a kidney specialist at Vanderbilt University, has been working to create an implantable part-biological and part-artificial kidney. Using microchips like those used in computers, he has produced an artificial kidney small enough to implant in the patient\u2019s body in place of the failed kidney. According to Dr. Fissell, the artificial kidney is \u201c... a bio-hybrid device that can mimic a kidney to remove enough waste products, salt, and water to keep a patient off [hemo]dialysis.\u201d<\/p>\n<p>The filtration system in the artificial kidney consists of a stack of 15 microchips. Tiny pores in the microchips act as a scaffold for the growth of living kidney\u00a0cells\u00a0that can mimic the natural functions of the kidney. The living cells form a membrane to filter the patient\u2019s blood as a biological kidney would, but with less risk of rejection by the patient\u2019s immune system, because they are embedded within the device. The new kidney doesn\u2019t need a power source, because it uses the natural pressure of blood flowing through arteries to push the blood through the filtration system. A major part of the design of the artificial organ was devoted to fine tuning the fluid dynamics so blood flows through the device without clotting.<\/p>\n<p>Because of the potential life-saving benefits of the device, the implantable kidney was given fast-track approval for testing in people by the U.S. Food and Drug Administration. The artificial kidney is expected to be tested in pilot trials by 2018. Dr. Fissell says he has a long list of patients eager to volunteer for the trials.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The two bean-shaped kidneys are located high in the back of the abdominal cavity on either side of the spine. A renal artery connects each kidney with the aorta, and transports unfiltered blood to the kidney. A renal vein connects each kidney with the inferior vena cava and transports filtered blood back to the\u00a0circulation.<\/li>\n<li>The kidney has two main layers involved in the filtration of blood and formation of urine: the outer cortex and inner medulla. At least a million nephrons \u2014 which are the tiny functional units of the kidney \u2014 span the cortex and medulla. The entire kidney is surrounded by a fibrous capsule and protective fat layers.<\/li>\n<li>As blood flows through a nephron, many materials are filtered out of the blood, needed materials are returned to the blood, and the remaining materials are used to form urine.<\/li>\n<li>In each nephron, the glomerulus and surrounding Bowman\u2019s capsule form the unit that filters blood. From Bowman\u2019s capsule, the material filtered from blood (called filtrate) passes through the long renal tubule. As it does, some substances are reabsorbed into the blood, and other substances are secreted from the blood into the filtrate, finally forming urine. The urine empties into collecting ducts, where more water may be reabsorbed.<\/li>\n<li>The kidneys control homeostasis with the help of endocrine hormones.\u00a0The kidneys, for example, are part of the renin-angiotensin-aldosterone system that regulates the concentration of sodium in the blood to control blood pressure. In this system, the\u00a0enzyme\u00a0renin secreted by the kidneys works with hormones from the liver and adrenal gland to stimulate nephrons to reabsorb more sodium and water from urine.<\/li>\n<li>The kidneys also secrete endocrine hormones, including calcitriol \u2014 which helps control the level of calcium in the blood \u2014 and erythropoietin, which stimulates bone marrow to produce red blood\u00a0cells.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-415\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-415\" class=\"h5p-iframe\" data-content-id=\"415\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"16.4 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Contrast the renal artery and renal vein.<\/li>\n<li>Identify the functions of a nephron.\u00a0Describe in detail what happens to fluids (blood, filtrate, and urine) as they pass through the parts of a nephron.<\/li>\n<li>Identify two endocrine hormones secreted by the kidneys, along with the functions they control.<\/li>\n<li>Name two regions in the kidney where water is reabsorbed.<\/li>\n<li>Is the blood in the glomerular capillaries more or less filtered than the blood in the peritubular capillaries? Explain your answer.<\/li>\n<li>What do you think would happen if\u00a0blood flow to the kidneys is blocked?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/FN3MFhYPWWo<\/p>\n<p style=\"text-align: center\">How do your kidneys work? - Emma Bryce, TED-Ed, 2015.<\/p>\n<p>https:\/\/youtu.be\/es-t8lO1KpA<\/p>\n<p style=\"text-align: center\">Urine Formation, Hamada Abass, 2013.<\/p>\n<p>https:\/\/youtu.be\/bX3C201O4MA<\/p>\n<p style=\"text-align: center\">Printing a human kidney - Anthony Atala, TED-Ed, 2013.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 16.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/haynes\/3403969320\" rel=\"cc:attributionURL\">Steak and Kidney Pie<\/a> by <a class=\"owner-name truncate\" title=\"Go to Charles Haynes's photostream\" href=\"https:\/\/www.flickr.com\/photos\/haynes\/\" data-track=\"attributionNameClick\">Charles Haynes<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\" rel=\"license\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 16.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Gray1120.png\" rel=\"cc:attributionURL\">Gray Kidneys<\/a> by\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Henry_Vandyke_Carter\">Henry Vandyke Carter<\/a>\u00a0(1831-1897) on Wikimedia Commons is in the \u00a0<a class=\"extiw\" title=\"en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain). (<a class=\"extiw\" title=\"en:Bartleby.com\" href=\"https:\/\/en.wikipedia.org\/wiki\/Bartleby.com\">Bartleby.com<\/a>:\u00a0<a class=\"external text\" href=\"http:\/\/www.bartleby.com\/107\/\" rel=\"nofollow\">Gray\u2019s Anatomy<\/a>, <a class=\"external text\" href=\"http:\/\/www.bartleby.com\/107\/illus1120.html\" rel=\"nofollow\">Plate 1120<\/a>).<\/p>\n<p><strong>Figure 16.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0592_KidneyAnatomy_01.png\" rel=\"cc:attributionURL\">Blausen_0592_KidneyAnatomy_01<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a>\u00a0on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Diagram_showing_how_the_kidneys_work_CRUK_138.svg\" rel=\"cc:attributionURL\">Diagram_showing_how_the_kidneys_work_CRUK_138.svg<\/a> by <a class=\"external text\" href=\"http:\/\/www.cancerresearchuk.org\/\" rel=\"nofollow\">Cancer Research UK<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.4.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2611_Blood_Flow_in_the_Nephron.jpg\" rel=\"cc:attributionURL\">Blood_Flow_in_the_Nephron<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.4.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Physiology_of_Nephron.png\" rel=\"cc:attributionURL\">1024px-Physiology_of_Nephron<\/a> by <a title=\"User:Madhero88\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Madhero88\">Madhero88<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.4.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2618_Nephron_Secretion_Reabsorption.jpg\" rel=\"cc:attributionURL\">Nephron_Secretion_Reabsorption<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-6-tubular-reabsorption\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.4.8<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Weewee.JPG\" rel=\"cc:attributionURL\">Urine<\/a> by <a class=\"extiw\" title=\"en:User:Markhamilton\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Markhamilton\">User:Markhamilton<\/a> at <a class=\"extiw\" title=\"en:Main Page\" href=\"https:\/\/en.wikipedia.org\/wiki\/Main_Page\">English Wikipedia<\/a> on Wikimedia Commons is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.4.9<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2712_Renin_Angiotensin_System-01.jpg\" rel=\"cc:attributionURL\">Renin_Angiotensin_System-01<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/26-3-electrolyte-balance\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text focus\" data-timestamp=\"1597634737557\" data-highlight-id=\"78b92c1f-19a8-4f25-a51f-bbc8324f8001\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text focus\" data-timestamp=\"1597634737557\" data-highlight-id=\"78b92c1f-19a8-4f25-a51f-bbc8324f8001\" data-highlighted=\"true\">25.10<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"4696\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text focus\" data-timestamp=\"1597634737557\" data-highlight-id=\"78b92c1f-19a8-4f25-a51f-bbc8324f8001\" data-highlighted=\"true\">Blood flow in the nephron [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 25.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney<\/span><\/span><\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635089440\" data-highlight-id=\"44eee2fb-aa0d-4804-9be2-6a8facf0058f\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635089440\" data-highlight-id=\"44eee2fb-aa0d-4804-9be2-6a8facf0058f\" data-highlighted=\"true\">25.17<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"26834\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text last focus\" data-timestamp=\"1597635089440\" data-highlight-id=\"44eee2fb-aa0d-4804-9be2-6a8facf0058f\" data-highlighted=\"true\">Locations of secretion and reabsorption in the nephron <span id=\"4696\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text focus\" data-timestamp=\"1597634737557\" data-highlight-id=\"78b92c1f-19a8-4f25-a51f-bbc8324f8001\" data-highlighted=\"true\">[digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 25.6). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-6-tubular-reabsorption<\/span><\/span><\/span><\/span><\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635408675\" data-highlight-id=\"1dfb4674-6d07-43f5-aeac-06bacc555bc7\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635408675\" data-highlight-id=\"1dfb4674-6d07-43f5-aeac-06bacc555bc7\" data-highlighted=\"true\">26.14<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"41702\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635408675\" data-highlight-id=\"1dfb4674-6d07-43f5-aeac-06bacc555bc7\" data-highlighted=\"true\">The renin-angiotensin system <span id=\"26834\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text last focus\" data-timestamp=\"1597635089440\" data-highlight-id=\"44eee2fb-aa0d-4804-9be2-6a8facf0058f\" data-highlighted=\"true\"><span id=\"4696\" class=\"os-title\" data-type=\"title\">[digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 26.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/26-3-electrolyte-balance<\/span><\/span><\/span><\/span><\/span><\/p>\n<p class=\"hanging-indent\">Blausen.com Staff. (2014). Medical gallery of Blausen Medical 2014.\u00a0<i>WikiJournal of Medicine<\/i>\u00a0<b>1<\/b>\u00a0(2).\u00a0DOI:10.15347\/wjm\/2014.010.\u00a0ISSN\u00a02002-4436<\/p>\n<p class=\"hanging-indent\">Hamada Abass. (2013). Urine formation. YouTube. https:\/\/www.youtube.com\/watch?v=es-t8lO1KpA&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2015, February 9). How do your kidneys work? - Emma Bryce. YouTube. https:\/\/www.youtube.com\/watch?v=FN3MFhYPWWo&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2013, March 15). Printing a human kidney - Anthony Atala. YouTube. https:\/\/www.youtube.com\/watch?v=bX3C201O4MA&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3138\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3138\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4736\" aria-describedby=\"caption-attachment-4736\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4736\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Steak-and-Kidney-Pie-by-Charles-Haynes-on-flickr-1.jpg\" alt=\"16.4.1 Kidney Pie\" width=\"400\" height=\"356\"><figcaption id=\"caption-attachment-4736\" class=\"wp-caption-text\"><em>Figure 16.4.1 Steak and kidney pie!<\/em><\/figcaption><\/figure>\n<div>\n<h1>Kidneys on the Menu<\/h1>\n<\/div>\n<p>Pictured in Figure 16.4.1 is a steak and kidney pie; this savory dish is a British favorite. When kidneys are on a menu, they typically come from sheep, pigs, or cows. In these animals (as in the human animal), kidneys are the main organs of excretion.<\/p>\n<div>\n<h1>Location\u00a0of the Kidneys<\/h1>\n<\/div>\n<p>The two bean-shaped\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a><\/strong>\u00a0are located high in the back of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2991\">abdominal cavity<\/a>, one on each side of the spine. Both kidneys sit just below the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4292\">diaphragm<\/a>, the large\u00a0breathing\u00a0muscle that separates the abdominal and thoracic cavities. As you can see in the\u00a0following\u00a0figure, the right kidney is slightly smaller and lower than the left kidney. The right kidney is behind the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2989\">liver<\/a>, and the left kidney is behind the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4497\">spleen<\/a>. The\u00a0location\u00a0of the liver explains why the right kidney is smaller and lower than the left.<\/p>\n<figure id=\"attachment_4737\" aria-describedby=\"caption-attachment-4737\" style=\"width: 455px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4737\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Gray-Kidneys-1.png\" alt=\"16.4.2 Classic Kidney Illustration from Gray's Anatomy\" width=\"455\" height=\"600\"><figcaption id=\"caption-attachment-4737\" class=\"wp-caption-text\"><em>Figure 16.4.2 This classic illustration of the abdominal cavity provides a view of the internal organs from the back of the body. It clearly shows the locations of the right and left kidney, as well as the large blood vessels that connect the kidneys to the body\u2019s main artery (aorta) and vein (inferior vena cava). The ureter exiting each kidney is also shown in the diagram.<\/em><\/figcaption><\/figure>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Kidney Anatomy<\/span><\/p>\n<p>The shape of each kidney gives it a convex side (curving outward) and a concave side (curving inward). You can see this clearly in the detailed diagram of kidney anatomy shown in Figure 16.4.3. The concave side is where the renal artery enters the kidney, as well as where the renal vein and ureter leave the kidney. This area of the kidney is called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4739\">hilum<\/a><\/strong>. The entire kidney is surrounded by tough fibrous tissue \u2014 called the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4740\">renal capsule<\/a><\/strong>\u00a0\u2014 which, in turn, is surrounded by two layers of protective, cushioning fat.<\/p>\n<figure id=\"attachment_4738\" aria-describedby=\"caption-attachment-4738\" style=\"width: 765px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4738\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0592_KidneyAnatomy_01-1.png\" alt=\"16.4.3 Kidney Anatomy\" width=\"765\" height=\"574\"><figcaption id=\"caption-attachment-4738\" class=\"wp-caption-text\"><em>Figure 16.4.3 This diagram shows the location and relative size of the two kidneys, as well as the internal structure of each kidney.<\/em><\/figcaption><\/figure>\n<p>Internally, each kidney is divided into two major layers: the outer <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4741\"><strong>renal cortex<\/strong><\/a> and the inner <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4742\"><strong>renal medulla<\/strong><\/a> (see Figure 16.4.3 above). These layers take the shape of many cone-shaped renal lobules, each containing renal cortex surrounding a portion of medulla called a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4743\"><strong>renal pyramid<\/strong><\/a>. Within the renal pyramids are the structural and functional units of the kidneys, the tiny <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephron<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. Between the renal pyramids are projections of cortex called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4744\"><strong>renal columns<\/strong><\/a>. The tip, or papilla, of each pyramid empties urine into a minor calyx (chamber). Several minor calyces empty into a major calyx, and the latter empty into the funnel-shaped cavity called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a>, which becomes the ureter as it leaves the kidney.<\/span><\/p>\n<div>\n<h3>Renal\u00a0Circulation<\/h3>\n<\/div>\n<p>The renal circulation is an important part of the kidney\u2019s primary function of filtering waste products from the blood. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2702\">Blood<\/a> is supplied to the kidneys via the renal arteries. The right renal artery supplies the right kidney, and the left renal artery supplies the left kidney. These two arteries branch directly from the aorta, which is the largest artery in the body. Each kidney is only about 11 cm (4.4 in) long, and has a mass of just 150 grams (5.3 oz), yet it receives about ten per cent of the total output of blood from the heart. Blood is filtered through the kidneys every 3 minutes, 24 hours a day, every day of your life.<\/p>\n<p>As indicated in Figure 16.4.4, each renal artery carries blood with waste products into the kidney. Within the kidney, the renal artery branches into increasingly smaller <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4385\">arteries<\/a> that extend through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4744\">renal columns<\/a> between the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4743\">renal pyramids<\/a>. These arteries, in turn, branch into arterioles that penetrate the renal pyramids. Blood in the arterioles passes through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephrons<\/a>, the structures that actually filter the blood. After blood passes through the nephrons and is filtered, the clean blood moves through a network of venules that converge into small <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4386\">veins<\/a>. Small veins merge into increasingly larger ones, and ultimately into the renal vein, which carries clean blood away from the kidney to the inferior <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4410\">vena cava<\/a>.<\/p>\n<figure id=\"attachment_4745\" aria-describedby=\"caption-attachment-4745\" style=\"width: 683px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4745\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Diagram_showing_how_the_kidneys_work_CRUK_138.svg_-1.png\" alt=\"16.4.4 Kidney and Nephron\" width=\"683\" height=\"719\"><figcaption id=\"caption-attachment-4745\" class=\"wp-caption-text\"><em>Figure 16.4.4 The renal artery and renal vein carry blood to and from the kidney, respectively. As blood passes through a nephron within the kidney, it is filtered. Substances filtered from the blood are eventually collected in a tubule (collecting duct).<\/em><\/figcaption><\/figure>\n<div>\n<h1>Nephron Structure and Function<\/h1>\n<\/div>\n<p>Figure 16.4.4 gives an indication of the complex structure of a nephron. The <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephron<\/a><\/strong>\u00a0is the basic structural and functional unit of the kidney, and each kidney typically contains at least a million of them. As blood flows through a nephron, many materials are filtered out of the blood, needed materials are returned to the blood, and the remaining materials form urine. Most of the waste products removed from the blood and excreted in urine are byproducts of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_176\">metabolism<\/a>. At least half of the waste is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, a waste product produced by\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_297\">protein<\/a>\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_178\">catabolism<\/a>. Another important waste is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4709\">uric\u00a0acid<\/a>, produced in\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4727\">nucleic acid<\/a>\u00a0catabolism.<\/p>\n<h2>Components of a Nephron<\/h2>\n<p>Figure 16.4.5 shows in greater detail the components of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephron<\/a>. Each nephron is composed of an initial filtering component that consists of a network of capillaries called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4747\">glomerulus<\/a><\/strong>\u00a0(plural, glomeruli), which is surrounded by a space within a structure\u00a0called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4748\">glomerular capsule<\/a> <\/strong>(also known as the Bowman's capsule). Extending from glomerular capsule is the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4749\">renal tubule<\/a><\/strong>. The proximal end (nearest glomerular capsule) of the renal tubule is called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4750\">proximal convoluted (coiled) tubule<\/a><\/strong>. From here, the renal tubule continues as a loop (known as the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4751\"><strong>loop of Henle<\/strong><\/a>) (also known as the loop of the nephron), which in turn becomes the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4752\"><strong>distal convoluted tubule<\/strong><\/a>. The latter finally joins with a collecting duct. As you can see in the diagram, arterioles surround the total length of the renal tubule in a mesh called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4753\"><strong>peritubular capillary network<\/strong><\/a>.<\/p>\n<figure id=\"attachment_4746\" aria-describedby=\"caption-attachment-4746\" style=\"width: 425px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4746\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blood_Flow_in_the_Nephron-1.jpg\" alt=\"16.4.5 Nephron\" width=\"425\" height=\"600\"><figcaption id=\"caption-attachment-4746\" class=\"wp-caption-text\"><em>Figure 16.4.5 This model of an individual nephron shows each of the structures that are involved in filtering blood, returning needed materials to blood, or excreting wastes that form urine.<\/em><\/figcaption><\/figure>\n<div><\/div>\n<figure id=\"attachment_4754\" aria-describedby=\"caption-attachment-4754\" style=\"width: 257px\" class=\"wp-caption alignright\"><img class=\"size-medium wp-image-4754\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/1024px-Physiology_of_Nephron-1.png\" alt=\"16.4.6 Urine Formation at the Nephron\" width=\"257\" height=\"300\"><figcaption id=\"caption-attachment-4754\" class=\"wp-caption-text\">Figure 16.4.6 This diagram of a nephron shows the parts of the nephron where different stages of nephron function take place. These stages are filtration, reabsorption, secretion, and excretion.<\/figcaption><\/figure>\n<h2>Function of a Nephron<\/h2>\n<p>The simplified diagram of a nephron in Figure 16.4.6 shows an overview of how the nephron functions. Blood enters the nephron through an arteriole called the afferent arteriole. Next, some of the blood passes through the capillaries of the glomerulus. Any blood that doesn\u2019t pass through the glomerulus \u2014 as well as blood after it passes through the glomerular capillaries \u2014 continues on through an arteriole called the efferent arteriole. The efferent arteriole follows the renal tubule of the nephron, where it continues\u00a0playing a role\u00a0in nephron functioning.<\/p>\n<p>&nbsp;<\/p>\n<h3>Filtration<\/h3>\n<p>As blood from the afferent arteriole flows through the glomerular capillaries, it is under pressure. Because of the pressure, water and solutes are filtered out of the blood and into the space made by glomerular capsule, almost like the water you cook pasta is is filtered out through a strainer. This is the filtration stage of nephron function. The filtered substances \u2014 called <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4755\">filtrate<\/a><\/strong> \u2014 pass into glomerular capsule, and from there into the proximal end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4749\">renal tubule<\/a>.\u00a0 Anything too large to move through the pores in the glomerulus, such as blood cells, large proteins, etc., stay in the cardiovascular system.\u00a0 At this stage, filtrate (fluid in the nephron) includes water, salts, organic solids (such as nutrients), and waste products of metabolism (such as urea).<\/p>\n<figure id=\"attachment_4756\" aria-describedby=\"caption-attachment-4756\" style=\"width: 403px\" class=\"wp-caption alignright\"><img class=\" wp-image-4756\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nephron_Secretion_Reabsorption-1.jpg\" alt=\"16.4.7 Nephron Secretion and Reabsorption\" width=\"403\" height=\"769\"><figcaption id=\"caption-attachment-4756\" class=\"wp-caption-text\"><em>Figure 16.4.7 Secretion and reabsorption happen along the length of the renal tubule as the nephron balances blood pH and volume and maintains homeostasis of ions in the blood. Reabsorption is the movement of substance back into the bloodstream and secretion is movement of substances from the blood into the nephron for excretion.<\/em><\/figcaption><\/figure>\n<h3>Reabsorption and Secretion<\/h3>\n<p>As filtrate moves through the renal tubule, some of the substances it contains are reabsorbed from the filtrate back into the blood in the efferent arteriole (via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4753\">peritubular capillary network<\/a>). This is the reabsorption stage of nephron function and it is about returning \"the good stuff\" back to the blood so that it doesn't exit the body in urine. About two-thirds of the filtered salts and water, and all of the filtered organic solutes (mainly <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_317\">glucose<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_305\">amino acid<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">) are reabsorbed from the filtrate by the blood in the peritubular capillary network. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4757\">Reabsorption<\/a> occurs mainly in the proximal convoluted tubule and the loop of Henle, as seen in Figure 16.4.7.<\/span><\/p>\n<p>At the distal end of the renal tubule, some additional reabsorption generally occurs. This is also the region of the tubule where other substances from the blood are added to the filtrate in the tubule. The addition of other substances to the filtrate from the blood is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4758\">secretion<\/a><\/strong>. Both reabsorption and secretion (shown in Figure 16.4.7) in the distal convoluted tubule are largely under the control of endocrine hormones that maintain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a> of water and mineral salts in the blood. These hormones work by controlling what is reabsorbed into the blood from the filtrate and what is secreted from the blood into the filtrate to become urine. For example, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3467\">parathyroid hormone<\/a> causes more calcium to be reabsorbed into the blood and more phosphorus to be secreted into the filtrate.<\/p>\n<h2>Collection of Urine and Excretion<\/h2>\n<figure id=\"attachment_4760\" aria-describedby=\"caption-attachment-4760\" style=\"width: 219px\" class=\"wp-caption alignleft\"><img class=\" wp-image-4760\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Weewee-1.jpg\" alt=\"16.4.8 Urine\" width=\"219\" height=\"478\"><figcaption id=\"caption-attachment-4760\" class=\"wp-caption-text\"><em>Figure 16.4.8 Fresh urine is typically yellow or amber in colour.<\/em><\/figcaption><\/figure>\n<p>By the time the filtrate has passed through the entire renal tubule, it has become the\u00a0liquid\u00a0waste known as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>. Urine empties from the distal end of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4749\">renal tubule<\/a> into a\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4759\">collecting duct<\/a><\/strong>. From there, the urine flows into increasingly larger collecting ducts. As urine flows through the system of collecting ducts, more water may be reabsorbed from it. This will occur in the presence of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4728\">antidiuretic\u00a0hormone\u00a0<\/a>from the\u00a0posterior\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2938\">pituitary gland<\/a>. This\u00a0hormone\u00a0makes the collecting ducts permeable to water, allowing water molecules to pass through them into capillaries by\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1148\">osmosis<\/a>, while preventing the passage of ions or other solutes. As much as 75% of the water may be reabsorbed from urine in the collecting ducts, making the urine more concentrated.<\/p>\n<p>Urine finally exits the largest collecting ducts through the renal papillae. It empties into the renal calyces, and finally into the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a>. From there, it travels through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureter<\/a> to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a> for eventual excretion from the body. An average of roughly 1.5 litres (a little over 6 cups) of urine is excreted each day. Normally, urine is yellow or amber in colour (see <span style=\"font-size: 1em\">Figure 16.4.8<\/span><span style=\"text-align: initial;font-size: 1em\">). The darker the colour, generally speaking, the more concentrated the urine is.<\/span><\/p>\n<p>&nbsp;<\/p>\n<div><span style=\"font-size: 1.602em;font-weight: bold\">Other Functions of the Kidneys<\/span><\/div>\n<p>Besides filtering blood and forming urine for excretion of soluble wastes, the kidneys have several vital functions in maintaining body-wide\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a>. Most of these functions are related to the\u00a0composition\u00a0or volume of urine formed by the kidneys. The kidneys must maintain the proper balance of water and salts in the body, normal\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4480\">blood pressure<\/a>, and the correct range of blood\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4330\">pH<\/a>. Through the processes of absorption and secretion by nephrons, more or less water, salt ions, acids, or bases are returned to the blood or excreted in urine, as needed, to maintain homeostasis.<\/p>\n<h2>Blood Pressure\u00a0Regulation<\/h2>\n<p>The kidneys do not control homeostasis all alone. As indicated above, endocrine hormones are also involved. Consider the regulation of\u00a0blood pressure\u00a0by the kidneys. Blood pressure is the pressure exerted by blood on the walls of the arteries. The regulation of blood pressure is part of a complex system, called the renin-angiotensin-aldosterone system. This system regulates the\u00a0concentration\u00a0of sodium in the blood to control blood pressure.<\/p>\n<figure id=\"attachment_4761\" aria-describedby=\"caption-attachment-4761\" style=\"width: 736px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4761\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Renin_Angiotensin_System-01-1.jpg\" alt=\"16.4.9 Regulation of Blood Pressure\" width=\"736\" height=\"336\"><figcaption id=\"caption-attachment-4761\" class=\"wp-caption-text\"><em>Figure 16.4.9 This diagram summarizes the processes that occur in the regulation of blood pressure by the renin-angiotensin-aldosterone system. The final step on the far right occurs in the nephrons and collecting ducts of the kidneys, where aldosterone stimulates increased reabsorption of sodium and water into the blood.<\/em><\/figcaption><\/figure>\n<p>The renin-angiotensin-aldosterone system is put into play when the\u00a0concentration\u00a0of sodium ions in the blood falls lower than normal. This causes the kidneys to secrete an\u00a0enzyme\u00a0called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4762\">renin<\/a> into the blood. It also causes the liver to secrete a\u00a0protein\u00a0called angiotensinogen. Renin changes angiotensinogen into a proto-hormone\u00a0called\u00a0angiotensin I. This is converted to angiotensin II by an\u00a0enzyme\u00a0(angiotensin-converting enzyme) in lung capillaries.<\/p>\n<p>Angiotensin II is a potent hormone that causes arterioles to constrict. This, in turn, increases blood pressure. Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex. Aldosterone causes the kidneys to increase the reabsorption of sodium ions and water from the filtrate into the blood. This returns the\u00a0concentration\u00a0of sodium ions in the blood to normal. The increased water in the blood also increases blood volume and blood pressure.<\/p>\n<h2>Other Kidney Hormones<\/h2>\n<p>Hormones other than renin are also produced and secreted by the kidneys. These include calcitriol and erythropoietin.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4763\">Calcitriol<\/a><\/strong>\u00a0is secreted by the kidneys in response to low levels of calcium in the blood. This hormone stimulates uptake of calcium by the intestine, thus raising blood levels of calcium.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4764\">Erythropoietin<\/a><\/strong> is secreted by the kidneys in response to low levels of oxygen in the blood. This hormone stimulates erythropoiesis, which is the production of\u00a0 <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4398\">erythrocytes<\/a>\u00a0in bone marrow. Extra red blood cells increase the level of oxygen carried in the blood.<\/li>\n<\/ul>\n<div>\n<h1>Feature: Human Biology in the News<\/h1>\n<\/div>\n<p>Kidney failure is a complication of common disorders including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2771\">diabetes mellitus<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4231\">hypertension<\/a>. It is estimated that approximately 12.5% of Canadians have some form of kidney disease.\u00a0 If the disease is serious, the patient must either receive a donated kidney or have frequent hemodialysis, a medical procedure in which the blood is artificially filtered through a machine. Transplant generally results in better outcomes than hemodialysis, but demand for organs far outstrips the supply. The average time on the organ donation waitlist for a kidney is four years.\u00a0 There are over 3,000 Canadians on the wait list for a kidney transplant and some will die waiting for a kidney to become available.<\/p>\n<p>For the past decade, Dr. William Fissell, a kidney specialist at Vanderbilt University, has been working to create an implantable part-biological and part-artificial kidney. Using microchips like those used in computers, he has produced an artificial kidney small enough to implant in the patient\u2019s body in place of the failed kidney. According to Dr. Fissell, the artificial kidney is \u201c... a bio-hybrid device that can mimic a kidney to remove enough waste products, salt, and water to keep a patient off [hemo]dialysis.\u201d<\/p>\n<p>The filtration system in the artificial kidney consists of a stack of 15 microchips. Tiny pores in the microchips act as a scaffold for the growth of living kidney\u00a0cells\u00a0that can mimic the natural functions of the kidney. The living cells form a membrane to filter the patient\u2019s blood as a biological kidney would, but with less risk of rejection by the patient\u2019s immune system, because they are embedded within the device. The new kidney doesn\u2019t need a power source, because it uses the natural pressure of blood flowing through arteries to push the blood through the filtration system. A major part of the design of the artificial organ was devoted to fine tuning the fluid dynamics so blood flows through the device without clotting.<\/p>\n<p>Because of the potential life-saving benefits of the device, the implantable kidney was given fast-track approval for testing in people by the U.S. Food and Drug Administration. The artificial kidney is expected to be tested in pilot trials by 2018. Dr. Fissell says he has a long list of patients eager to volunteer for the trials.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The two bean-shaped kidneys are located high in the back of the abdominal cavity on either side of the spine. A renal artery connects each kidney with the aorta, and transports unfiltered blood to the kidney. A renal vein connects each kidney with the inferior vena cava and transports filtered blood back to the\u00a0circulation.<\/li>\n<li>The kidney has two main layers involved in the filtration of blood and formation of urine: the outer cortex and inner medulla. At least a million nephrons \u2014 which are the tiny functional units of the kidney \u2014 span the cortex and medulla. The entire kidney is surrounded by a fibrous capsule and protective fat layers.<\/li>\n<li>As blood flows through a nephron, many materials are filtered out of the blood, needed materials are returned to the blood, and the remaining materials are used to form urine.<\/li>\n<li>In each nephron, the glomerulus and surrounding Bowman\u2019s capsule form the unit that filters blood. From Bowman\u2019s capsule, the material filtered from blood (called filtrate) passes through the long renal tubule. As it does, some substances are reabsorbed into the blood, and other substances are secreted from the blood into the filtrate, finally forming urine. The urine empties into collecting ducts, where more water may be reabsorbed.<\/li>\n<li>The kidneys control homeostasis with the help of endocrine hormones.\u00a0The kidneys, for example, are part of the renin-angiotensin-aldosterone system that regulates the concentration of sodium in the blood to control blood pressure. In this system, the\u00a0enzyme\u00a0renin secreted by the kidneys works with hormones from the liver and adrenal gland to stimulate nephrons to reabsorb more sodium and water from urine.<\/li>\n<li>The kidneys also secrete endocrine hormones, including calcitriol \u2014 which helps control the level of calcium in the blood \u2014 and erythropoietin, which stimulates bone marrow to produce red blood\u00a0cells.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>\n<div id=\"h5p-195\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-195\" class=\"h5p-iframe\" data-content-id=\"195\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Active Transport\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Contrast the renal artery and renal vein.<\/li>\n<li>Identify the functions of a nephron.\u00a0Describe in detail what happens to fluids (blood, filtrate, and urine) as they pass through the parts of a nephron.<\/li>\n<li>Identify two endocrine hormones secreted by the kidneys, along with the functions they control.<\/li>\n<li>Name two regions in the kidney where water is reabsorbed.<\/li>\n<li>Is the blood in the glomerular capillaries more or less filtered than the blood in the peritubular capillaries? Explain your answer.<\/li>\n<li>What do you think would happen if\u00a0blood flow to the kidneys is blocked?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/FN3MFhYPWWo<\/p>\n<p style=\"text-align: center\">How do your kidneys work? - Emma Bryce, TED-Ed, 2015.<\/p>\n<p>https:\/\/youtu.be\/es-t8lO1KpA<\/p>\n<p style=\"text-align: center\">Urine Formation, Hamada Abass, 2013.<\/p>\n<p>https:\/\/youtu.be\/bX3C201O4MA<\/p>\n<p style=\"text-align: center\">Printing a human kidney - Anthony Atala, TED-Ed, 2013.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 16.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/haynes\/3403969320\" rel=\"cc:attributionURL\">Steak and Kidney Pie<\/a> by <a class=\"owner-name truncate\" title=\"Go to Charles Haynes's photostream\" href=\"https:\/\/www.flickr.com\/photos\/haynes\/\" data-track=\"attributionNameClick\">Charles Haynes<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\" rel=\"license\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 16.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Gray1120.png\" rel=\"cc:attributionURL\">Gray Kidneys<\/a> by\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Henry_Vandyke_Carter\">Henry Vandyke Carter<\/a>\u00a0(1831-1897) on Wikimedia Commons is in the \u00a0<a class=\"extiw\" title=\"en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/public_domain). (<a class=\"extiw\" title=\"en:Bartleby.com\" href=\"https:\/\/en.wikipedia.org\/wiki\/Bartleby.com\">Bartleby.com<\/a>:\u00a0<a class=\"external text\" href=\"http:\/\/www.bartleby.com\/107\/\" rel=\"nofollow\">Gray\u2019s Anatomy<\/a>, <a class=\"external text\" href=\"http:\/\/www.bartleby.com\/107\/illus1120.html\" rel=\"nofollow\">Plate 1120<\/a>).<\/p>\n<p><strong>Figure 16.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0592_KidneyAnatomy_01.png\" rel=\"cc:attributionURL\">Blausen_0592_KidneyAnatomy_01<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a>\u00a0on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Diagram_showing_how_the_kidneys_work_CRUK_138.svg\" rel=\"cc:attributionURL\">Diagram_showing_how_the_kidneys_work_CRUK_138.svg<\/a> by <a class=\"external text\" href=\"http:\/\/www.cancerresearchuk.org\/\" rel=\"nofollow\">Cancer Research UK<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.4.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2611_Blood_Flow_in_the_Nephron.jpg\" rel=\"cc:attributionURL\">Blood_Flow_in_the_Nephron<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.4.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Physiology_of_Nephron.png\" rel=\"cc:attributionURL\">1024px-Physiology_of_Nephron<\/a> by <a title=\"User:Madhero88\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Madhero88\">Madhero88<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.4.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2618_Nephron_Secretion_Reabsorption.jpg\" rel=\"cc:attributionURL\">Nephron_Secretion_Reabsorption<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-6-tubular-reabsorption\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 16.4.8<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Weewee.JPG\" rel=\"cc:attributionURL\">Urine<\/a> by <a class=\"extiw\" title=\"en:User:Markhamilton\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Markhamilton\">User:Markhamilton<\/a> at <a class=\"extiw\" title=\"en:Main Page\" href=\"https:\/\/en.wikipedia.org\/wiki\/Main_Page\">English Wikipedia<\/a> on Wikimedia Commons is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.4.9<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2712_Renin_Angiotensin_System-01.jpg\" rel=\"cc:attributionURL\">Renin_Angiotensin_System-01<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/26-3-electrolyte-balance\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text focus\" data-timestamp=\"1597634737557\" data-highlight-id=\"78b92c1f-19a8-4f25-a51f-bbc8324f8001\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text focus\" data-timestamp=\"1597634737557\" data-highlight-id=\"78b92c1f-19a8-4f25-a51f-bbc8324f8001\" data-highlighted=\"true\">25.10<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"4696\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text focus\" data-timestamp=\"1597634737557\" data-highlight-id=\"78b92c1f-19a8-4f25-a51f-bbc8324f8001\" data-highlighted=\"true\">Blood flow in the nephron [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 25.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-3-gross-anatomy-of-the-kidney<\/span><\/span><\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635089440\" data-highlight-id=\"44eee2fb-aa0d-4804-9be2-6a8facf0058f\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635089440\" data-highlight-id=\"44eee2fb-aa0d-4804-9be2-6a8facf0058f\" data-highlighted=\"true\">25.17<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"26834\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text last focus\" data-timestamp=\"1597635089440\" data-highlight-id=\"44eee2fb-aa0d-4804-9be2-6a8facf0058f\" data-highlighted=\"true\">Locations of secretion and reabsorption in the nephron <span id=\"4696\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text focus\" data-timestamp=\"1597634737557\" data-highlight-id=\"78b92c1f-19a8-4f25-a51f-bbc8324f8001\" data-highlighted=\"true\">[digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 25.6). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-6-tubular-reabsorption<\/span><\/span><\/span><\/span><\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635408675\" data-highlight-id=\"1dfb4674-6d07-43f5-aeac-06bacc555bc7\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635408675\" data-highlight-id=\"1dfb4674-6d07-43f5-aeac-06bacc555bc7\" data-highlighted=\"true\">26.14<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"41702\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text focus\" data-timestamp=\"1597635408675\" data-highlight-id=\"1dfb4674-6d07-43f5-aeac-06bacc555bc7\" data-highlighted=\"true\">The renin-angiotensin system <span id=\"26834\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text last focus\" data-timestamp=\"1597635089440\" data-highlight-id=\"44eee2fb-aa0d-4804-9be2-6a8facf0058f\" data-highlighted=\"true\"><span id=\"4696\" class=\"os-title\" data-type=\"title\">[digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 26.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/26-3-electrolyte-balance<\/span><\/span><\/span><\/span><\/span><\/p>\n<p class=\"hanging-indent\">Blausen.com Staff. (2014). Medical gallery of Blausen Medical 2014.\u00a0<i>WikiJournal of Medicine<\/i>\u00a0<b>1<\/b>\u00a0(2).\u00a0DOI:10.15347\/wjm\/2014.010.\u00a0ISSN\u00a02002-4436<\/p>\n<p class=\"hanging-indent\">Hamada Abass. (2013). Urine formation. YouTube. https:\/\/www.youtube.com\/watch?v=es-t8lO1KpA&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2015, February 9). How do your kidneys work? - Emma Bryce. YouTube. https:\/\/www.youtube.com\/watch?v=FN3MFhYPWWo&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2013, March 15). Printing a human kidney - Anthony Atala. YouTube. https:\/\/www.youtube.com\/watch?v=bX3C201O4MA&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3139\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3139\"><div tabindex=\"-1\"><p>Image shows a photograph of a toy poodle peeing on a fire hydrant<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3140\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3140\"><div tabindex=\"-1\"><p>As per caption<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3141\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3141\"><div tabindex=\"-1\"><p>As per caption<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3142\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3142\"><div tabindex=\"-1\"><p>Image shows a diagram of the bladder, the locations where the ureters enter, the internal and external sphincters that keep urine in the bladder and the urethra.   There is also an inset pictomicrograph of the layers of the bladder wall with include transitional epithelia and mucose<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_2937\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_2937\"><div tabindex=\"-1\"><p>Created by: CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-455\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Free_Awesome_Girl_With_Braces_Close_Up.jpg\" alt=\"\" width=\"400\" height=\"409\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.1 Brace yourself!\u00a0<\/em><\/figcaption><\/figure>\n<h1>Oh, the Agony!<\/h1>\n<p>Wearing braces can be very uncomfortable, but it is usually worth it. Braces and other orthodontic treatments can re-align the teeth and jaws to improve bite and appearance. Braces can change the position of the teeth and the shape of the jaws because the human body is malleable. Many phenotypic traits \u2014 even those that have a strong genetic basis \u2014 can be molded by the environment. Changing the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2477\">phenotype<\/a> in response to the environment is just one of several ways we respond to environmental stress.<\/p>\n<div>\n<h1>Types of Responses to Environmental Stress<\/h1>\n<\/div>\n<p>There are four different types of responses that humans may make to cope with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2653\">environmental stress<\/a>:<\/p>\n<ol>\n<li>Adaptation<\/li>\n<li>Developmental adjustment<\/li>\n<li>Acclimatization<\/li>\n<li>Cultural responses<\/li>\n<\/ol>\n<p>The first three types of responses are biological in nature, and the fourth type is cultural. Only adaptation involves genetic change and occurs at the level of the population or species. The other three responses do not require genetic change, and they occur at the individual level.<\/p>\n<div>\n<h1>Adaptation<\/h1>\n<\/div>\n<p>An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2486\">adaptation<\/a><\/strong>\u00a0is a genetically-based trait that has evolved because it helps living things survive and reproduce in a given environment. Adaptations generally evolve in a population over many generations in response to stresses that last for a long period of time. Adaptations come about through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2633\">natural selection<\/a>. Those individuals who inherit a trait that confers an advantage in coping with an environmental stress are likely to live longer and reproduce more. As a result, more of their genes pass on to the next generation. Over many generations, the genes and the trait they control become more frequent in the population.<\/p>\n<h2>A Classic Example: Hemoglobin S and Malaria<\/h2>\n<p>Probably the most frequently-cited example of a genetic adaptation to an environmental stress is sickle cell trait. As you read in the previous section, people with sickle cell trait have one abnormal allele (S) and one normal allele (A) for hemoglobin, the red blood cell protein that carries oxygen in the blood. Sickle cell trait is an adaptation to the environmental stress of malaria, because people with the trait have resistance to this parasitic disease. In areas where malaria is endemic (present year-round), the sickle cell trait and its <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1942\">allele<\/a> have evolved to relatively high frequencies. \u00a0It is a classic example of natural selection favoring <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2474\">heterozygotes<\/a> for a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2035\">gene<\/a> with two <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1942\">alleles<\/a>. This type of selection keeps both alleles at relatively high frequencies in a population.<\/p>\n<h2>To Taste or Not to Taste<\/h2>\n<p>Another example of an adaptation in humans is the ability to taste bitter compounds. Plants produce a variety of toxic compounds in order to protect themselves from being eaten, and these toxic compounds often have a bitter taste. The ability to taste bitter compounds is thought to have evolved as an adaptation, because it prevented people from eating poisonous plants. Humans have many different genes that code for bitter taste receptors, allowing us to taste a wide variety of bitter compounds.<\/p>\n<p>A harmless bitter compound\u00a0called\u00a0<strong>phenylthiocarbamide (PTC)<\/strong>\u00a0is not found naturally in plants, but it is similar to toxic bitter compounds that\u00a0<em>are<\/em> found in plants. Humans' ability to taste this harmless substance has been tested in many different populations. In virtually every population studied, there are some people who can taste PTC (called tasters), and some people who cannot taste PTC, (called nontasters). The ratio of tasters to non-tasters varies among populations, but on average, 75 per cent of people can taste PTC and 25 per cent cannot.<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 272px\" class=\"wp-caption alignright\"><img class=\" wp-image-456\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Tongue.jpg\" alt=\"Tongue\" width=\"272\" height=\"288\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.2 The tiny red dots on the surface of the tongue consist of clumps of taste buds that contain receptor proteins for certain chemicals. We can taste those chemicals that bind strongly with any of the receptors.<\/em><\/figcaption><\/figure>\n<p>Like many scientific discoveries, human variation in PTC-taster status was discovered by chance. Around 1930, a chemist named Arthur Fox was working with powdered PTC in his lab. Some of the powder accidentally blew into the air. Another lab worker noticed that the powdered PTC tasted bitter, but Fox couldn't detect any taste at all. Fox wondered\u00a0how to explain\u00a0this difference in PTC-tasting ability. Geneticists soon determined that PTC-taster status is controlled by a single <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2035\">gene<\/a> with two common alleles, usually represented by the letters\u00a0<em>T<\/em>\u00a0and\u00a0<em>t<\/em>. The\u00a0<em>T<\/em> allele encodes a chemical receptor protein (found in taste buds on the tongue, as illustrated in Figure 6.4.2) that can strongly bind to PTC. The other allele, <em>t<\/em>, encodes a version of the receptor protein that cannot bind as strongly to PTC. The particular combination of these two alleles that a person inherits determines whether the person finds PTC to taste very bitter (<em>TT<\/em>), somewhat bitter\u00a0<em>(Tt),<\/em>\u00a0or not bitter at all\u00a0<em>(tt).<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>If the ability to taste bitter compounds is advantageous, why does every human population studied contain a significant percentage of people who are nontasters?\u00a0Why has the nontasting allele been preserved in human populations at all? Some scientists hypothesize that the nontaster allele actually confers the ability to taste some other, yet-to-be identified, bitter compound in plants. People who inherit both alleles would presumably be able to taste a wider range of bitter compounds, so they would have the greatest ability to avoid plant toxins. In other words, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2474\">heterozygote<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2715\">genotype<\/a> for the taster gene would be the most fit and favored by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2633\">natural selection<\/a>.<\/p>\n<p>Most people no longer have to worry whether the plants they eat contain toxins. The produce you grow in your garden or buy at the supermarket consists of known varieties that are safe to eat. However, natural selection may still be at work in human populations for the PTC-taster gene, because PTC tasters may be more sensitive than nontasters to bitter compounds in tobacco and vegetables in the cabbage family (that is, cruciferous vegetables, such as the broccoli, cauliflower, and cabbage pictured in Figure 6.4.3).<\/p>\n<ul>\n<li>People who find PTC to taste very bitter are less likely to smoke tobacco, presumably because tobacco smoke has a stronger bitter taste to these individuals. In this case, selection would favor taster genotypes, because tasters would be more likely to avoid smoking and its serious health risks.<\/li>\n<li>Strong tasters find cruciferous vegetables to taste bitter. As a result, they may avoid eating these vegetables (and perhaps other foods, as well), presumably resulting in a diet that is less varied and nutritious. In this scenario, natural selection\u00a0might\u00a0work against taster genotypes.<\/li>\n<\/ul>\n<p><span style=\"text-align: initial;font-size: 1em\"><\/p>\n<div id=\"h5p-86\">\n<div class=\"h5p-content\" data-content-id=\"86\"><\/div>\n<\/div>\n<p><\/span><\/p>\n<p><em>Figure 6.4.3 Cruciferous vegetables.<\/em><\/p>\n<div>\n<h1>Developmental Adjustment<\/h1>\n<\/div>\n<p>It takes a relatively long time for genetic change in response to environmental stress to produce a population with adaptations. Fortunately, we can adjust to some environmental stresses more quickly by changing in nongenetic ways. One type of nongenetic response to stress is\u00a0<strong>developmental adjustment.<\/strong>\u00a0This refers to phenotypic change that occurs during development in infancy or childhood, and that may persist into adulthood. This type of change may be irreversible by adulthood.<\/p>\n<h2>Phenotypic Plasticity<\/h2>\n<p>Developmental adjustment is possible because humans have a high degree of\u00a0<strong>phenotypic plasticity,<\/strong>\u00a0which is\u00a0the ability to alter\u00a0the<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2477\"> phenotype<\/a> in response to changes in the environment. Phenotypic plasticity allows us to respond to changes that occur within our lifetime, and it is particularly important for species\u00a0(like our own)\u00a0that have a long generation time. With long generations, evolution of genetic adaptations may occur too slowly to keep up with changing environmental stresses.<\/p>\n<h2>Developmental Adjustment and Cultural Practices<\/h2>\n<p>Developmental adjustment may be the result of naturally occurring environmental stresses or cultural practices, including medical or dental treatments. Like our example at the beginning of this section, using braces to change the shape of the jaw and the position of the teeth is an example of a dental practice that brings about a developmental adjustment. Another example of developmental adjustment is the use of a back brace to treat scoliosis (see images in <em>Figure 6.4.4<\/em>). Scoliosis is an abnormal curvature from side to side in the spine. If the problem is not too severe, a brace, if worn correctly, should prevent the curvature from worsening as a child grows, although it cannot straighten a curve that is already present. Surgery may be required to do that.<\/p>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 651px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-457\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg.png\" alt=\"\" width=\"651\" height=\"342\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.4 Scoliosis can be prevented from worsening by shaping the phenotype with a back brace.<\/em><\/figcaption><\/figure>\n<h2>Developmental Adjustment and Nutritional Stress<\/h2>\n<p>An important example of developmental adjustment that results from a naturally occurring environmental stress is the cessation of physical growth that occurs in children who are under nutritional stress. Children who lack adequate food to fuel both growth and basic metabolic processes are likely to slow down in their growth rate \u2014 or even to stop growing entirely. Shunting all available calories and nutrients into essential life functions may keep the child alive at the expense of increasing body size.<\/p>\n<p>Table 6.4.1 shows the effects of inadequate diet on children's' growth in several countries worldwide. For each country, the table gives the prevalence of <strong>stunting<\/strong>\u00a0in children under\u00a0the age of five. Children are considered stunted if their height is at least two standard deviations below the median height for their age in an international reference population.<\/p>\n<p><strong>Table 6.4.1<\/strong><\/p>\n<p><em>Percentage of Stunting in Young Children in Selected Countries (2011-2015)<\/em><\/p>\n<table class=\"grid aligncenter\" style=\"border-collapse: collapse;width: 53.0094%;height: 142px\" border=\"0\">\n<tbody>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 52.9369%;text-align: center\" colspan=\"2\"><strong>Percentage of Stunting in Young Children in Selected Countries (2011-2015)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 16px\">\n<td style=\"height: 16px;width: 22.19%\"><strong>Country<\/strong><\/td>\n<td style=\"height: 16px;width: 30.7469%\"><strong>Per cent of Children Under Age 5 with Stunting<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">United States<\/td>\n<td style=\"height: 14px;width: 30.7469%\">2.1<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Turkey<\/td>\n<td style=\"height: 14px;width: 30.7469%\">9.5<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Mexico<\/td>\n<td style=\"height: 14px;width: 30.7469%\">13.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Thailand<\/td>\n<td style=\"height: 14px;width: 30.7469%\">16.3<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Iraq<\/td>\n<td style=\"height: 14px;width: 30.7469%\">22.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Philippines<\/td>\n<td style=\"height: 14px;width: 30.7469%\">33.6<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Pakistan<\/td>\n<td style=\"height: 14px;width: 30.7469%\">45.0<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"height: 14px;width: 22.19%\">Papua New Guinea<\/td>\n<td style=\"height: 14px;width: 30.7469%\">49.5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>After a growth slow-down occurs and if adequate food becomes available, a child may be able to make up the loss of growth. If food is plentiful, the child may grow more rapidly than normal until the original, genetically-determined growth trajectory is reached. If the inadequate diet persists, however, the failure of growth may become chronic, and the child may never reach his or her full potential adult size.<\/p>\n<p>Phenotypic plasticity of body size in response to dietary change has been observed in successive generations within populations. For example, children in Japan were taller, on average, in each successive generation\u00a0after\u00a0the end of World War II. Boys aged 14-15 years old in 1986 were an average of about 18 cm (7 in.) taller than boys of the same age in 1959, a generation earlier. This is a highly significant difference, and it occurred too quickly to be accounted for by genetic change. Instead, the increase in height is a developmental adjustment, thought to be largely attributable to changes in the Japanese diet since World War II. During this period, there was an increase in the amount of animal protein and fat, as well as in the total calories consumed.<\/p>\n<div>\n<h1>Acclimatization<\/h1>\n<\/div>\n<p>Other responses to environmental stress are reversible and not permanent, whether they occur in childhood or adulthood. The development of reversible changes to environmental stress is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2483\">acclimatization<\/a>.<\/strong>\u00a0Acclimatization generally develops over a relatively short period of time.\u00a0It may take just a few days or weeks to attain a maximum response to a stress. When the stress is no longer present, the acclimatized state declines, and the body returns to its normal baseline state. Generally, the shorter the time for acclimatization to occur, the more quickly the condition is reversed when the environmental stress is removed.<\/p>\n<h2>Acclimatization to UV Light<\/h2>\n<p>A common example of acclimatization is tanning of the skin (see Figure 6.4.5). This occurs in many people in response to exposure to ultraviolet radiation from the sun. Special pigment cells in the skin, called melanocytes, produce more of the brown pigment melanin when exposed to sunlight. The melanin collects near the surface of the skin where it absorbs UV radiation so it cannot penetrate and potentially damage deeper skin structures. Tanning is a reversible change in the phenotype that helps the body deal temporarily with the environmental stress of high levels of UV radiation. When the skin is no longer exposed to the sun\u2019s rays, the tan fades, generally over a period of a few weeks or months.<\/p>\n<div id=\"h5p-87\">\n<div class=\"h5p-content\" data-content-id=\"87\"><\/div>\n<\/div>\n<p><em>Figure 6.4.5 Tanning of the skin occurs in many people in response to exposure to ultraviolet radiation from the sun.<\/em><\/p>\n<div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Acclimatization to Heat<\/span><\/p>\n<\/div>\n<p>Another common example of acclimatization occurs in response to heat. Changes that occur with heat acclimatization include increased sweat output and earlier onset of sweat production, which helps the body stay cool because evaporation of sweat takes heat from the body\u2019s surface in a process called evaporative cooling. It generally takes a couple of weeks for maximum heat acclimatization to come about by gradually working out harder and longer at high air temperatures. The changes that occur with acclimatization just as quickly subside when the body is no longer exposed to excessive heat.<\/p>\n<h2>Acclimatization to High Altitude<\/h2>\n<figure id=\"attachment_458\" aria-describedby=\"caption-attachment-458\" style=\"width: 420px\" class=\"wp-caption alignleft\"><img class=\" wp-image-458\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nepalese-base-camp-by-Mark-Horrell-on-Flickr-CC-BY-NC-SA-.jpg\" alt=\"Base camp in Nepal\" width=\"420\" height=\"315\"><figcaption id=\"caption-attachment-458\" class=\"wp-caption-text\"><em>Figure 6.4.6 Mountaineers must spend 4-5 days acclimatizing to high altitude before attempting to climb to the summit of Mount Everest.<\/em><\/figcaption><\/figure>\n<p>Short term acclimatization to high altitude occurs as a response to low levels of oxygen in the blood.\u00a0 This reduced level of oxygen is detected by carotid bodies, which will trigger in increase in breathing and heart rate.\u00a0 Over a period of weeks the body will compensate by increasing red blood cell production, thereby improving the oxygen-carrying capacity of the blood.\u00a0 This is why mountaineers wishing to climb to the peak of Mount Everest must complete the full climb in portions; it is recommended that climbers spend 2-3 days acclimatizing for every 600 metres of elevation increase.\u00a0 In addition, the higher to altitude, the longer it make take to acclimatize; climbers are advised to spend 4-5 days acclimatizing at base camp (whether the base camp in Nepal or China) before completing the final leg of the climb to the peak.\u00a0 The concentration of red blood cells gradually decreases to normal levels once a climber returns to their normal elevation.<\/p>\n<div>\n<h1>Cultural Responses<\/h1>\n<\/div>\n<p>More than any other species, humans respond to environmental stresses with learned behaviors and technology. These cultural responses allow us to change our environments to control stresses, rather than changing our bodies genetically or physiologically to cope with the stresses. Even archaic humans responded to some environmental stresses in this way. For example, Neanderthals used shelters, fires, and animal hides as clothing to stay warm in the cold climate in Europe during the last ice age. Today, we use more sophisticated technologies to stay warm in cold climates while retaining our essentially tropical-animal anatomy and physiology. We also use technology (such as furnaces and air conditioners) to avoid temperature stress and stay comfortable in hot or cold climates.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Humans may respond to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2653\">environmental stress <\/a>in four different ways: adaptation, developmental adjustment, acclimatization, and cultural responses.<\/li>\n<li>An adaptation is a genetically based trait that has evolved because it helps living things survive and reproduce in a given environment. Adaptations evolve by natural selection in populations over a relatively long period to time. Examples of adaptations include sickle cell trait as an adaptation to the stress of endemic malaria and the ability to taste bitter compounds as an adaptation to the stress of bitter-tasting toxins in plants.<\/li>\n<li>A developmental adjustment is a non-genetic response to stress that occurs during infancy or childhood, and that may persist into adulthood. This type of change may be irreversible. Developmental adjustment is possible because humans have a high degree of phenotypic plasticity. It may be the result of environmental stresses (such as inadequate food), which may stunt growth, or cultural practices (such as orthodontic treatments), which re-align the teeth and jaws.<\/li>\n<li>Acclimatization is the development of reversible changes to environmental stress that develop over a relatively short period of time. The changes revert to the normal baseline state after the stress is removed. Examples of acclimatization include tanning of the skin and physiological changes (such as increased sweating) that occur with heat acclimatization.<\/li>\n<li>More than any other species, humans respond to environmental stress with learned behaviors and technology, which are cultural responses. These responses allow us to change our environment to control stress, rather than changing our bodies genetically or physiologically to cope with stress. Examples include using shelter, fire, and clothing to cope with a cold climate.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>List four different types of responses that humans may make to cope with environmental stress.<\/li>\n<li>Define adaptation.<\/li>\n<li>\n<div id=\"h5p-88\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-88\" class=\"h5p-iframe\" data-content-id=\"88\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Human Responses to Environmental Stress\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Explain how natural selection may have resulted in most human populations having people who can and people who cannot taste PTC.<\/li>\n<li>What is a developmental adjustment?<\/li>\n<li>Define phenotypic plasticity.<\/li>\n<li>Explain why phenotypic plasticity may be particularly important in a species with a long generation time.<\/li>\n<li>Why may stunting of growth occur in children who have an inadequate diet? Why is stunting preferable to the alternative?<\/li>\n<li>What is acclimatization?<\/li>\n<li>How does acclimatization to heat come about, and what are two physiological changes that occur in heat acclimatization?<\/li>\n<li>Give an example of a cultural response to heat stress.<\/li>\n<li>Which is more likely to be reversible \u2014 a change due to acclimatization, or a change due to developmental adjustment? Explain your answer.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">6.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=upp9-w6GPhU<\/p>\n<p style=\"text-align: center\">Could we survive prolonged space travel? - Lisa Nip, TED-Ed, 2016.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=hRnrIpUMyZQ&amp;t=182s<\/p>\n<p style=\"text-align: center\">How this disease changes the shape of your cells - Amber M. Yates, TED-Ed, 2019.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 6.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Free_Awesome_Girl_With_Braces_Close_Up.jpg\" rel=\"cc:attributionURL\">Free_Awesome_Girl_With_Braces_Close_Up<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/people\/40645538@N00\" rel=\"nofollow\">D. Sharon Pruitt<\/a> from Hill Air Force Base, Utah, USA on Wikimedia Commons is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en) license.<\/p>\n<p><strong>Figure 6.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:%D8%B2%D8%A8%D8%A7%D9%86_tongue.jpg\" rel=\"cc:attributionURL\">Tongue<\/a> by <a class=\"new\" title=\"User:Mahdiabbasinv (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Mahdiabbasinv&amp;action=edit&amp;redlink=1\">Mahdiabbasinv<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en) license.<\/p>\n<p><strong>Figure 6.4.3<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/unsplash.com\/photos\/PT-GXFtQj-s\">White cauliflower on brown wooden chopping board<\/a> by <a href=\"https:\/\/unsplash.com\/@louishansel\">Louis Hansel @shotsoflouis<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/LpHYbY6Qu_o\">Broccoli on wooden chopping board<\/a> by <a href=\"https:\/\/unsplash.com\/@louishansel\">Louis Hansel @shotsoflouis<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/knGwkn2j4ro\">Green cabbage close up<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@photoliphecjd\">Craig Dimmick<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/2Qzk3EJLNGE\">Cabbage hybrid\/ brussel sprouts<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@darkersolstice\">Solstice Hannan<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/_zV74zUnwmc\">Kale<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@lauramakoj\">Laura Johnston<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/v25z8P-CPB4\">Tiny bok choy at the Asian market<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@twoluckyspoons\">Jodie Morgan<\/a>\u00a0on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a>\u00a0(https:\/\/unsplash.com\/license).<\/li>\n<\/ul>\n<p><strong>Figure 6.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg.png\" rel=\"cc:attributionURL\">Scoliosis_patient_in_cheneau_brace_correcting_from_56_to_27_deg<\/a> by Weiss H.R. from <a href=\"https:\/\/scoliosisjournal.biomedcentral.com\/articles\/10.1186\/1748-7161-2-19\">Scoliosis Journal\/BioMed Central Ltd<\/a>. on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" rel=\"license\">CC BY 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 6.4.5<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/21077319@N02\/3667901661\">Tan Lines<\/a> by <a class=\"owner-name truncate\" title=\"Go to k.steudel's photostream\" href=\"https:\/\/www.flickr.com\/photos\/snaks\/\" data-track=\"attributionNameClick\">k.steudel<\/a> on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/3760162521\/sizes\/l\/\">Twin tan lines (all sizes)<\/a> by <a class=\"owner-name truncate\" title=\"Go to Quinn Dombrowski's photostream\" href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/\" data-track=\"attributionNameClick\">Quinn Dombrowski<\/a>\u00a0on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/14518898810\">Wedding ring tan line<\/a> by <a class=\"owner-name truncate\" title=\"Go to Quinn Dombrowski's photostream\" href=\"https:\/\/www.flickr.com\/photos\/quinnanya\/\" data-track=\"attributionNameClick\">Quinn Dombrowski<\/a>\u00a0on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/\">CC BY-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/29333334@N06\/3792695572\">Tan<\/a> by <a class=\"owner-name truncate\" title=\"Go to Evil Erin's photostream\" href=\"https:\/\/www.flickr.com\/photos\/evilerin\/\" data-track=\"attributionNameClick\">Evil Erin<\/a> on <a href=\"http:\/\/Flickr.com\">Flickr<\/a> is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<\/ul>\n<p><strong style=\"text-align: initial;font-size: 1em\">Figure 6.4.6<\/strong><\/p>\n<p><a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/www.flickr.com\/photos\/markhorrell\/18787430274\/in\/photostream\/\" rel=\"cc:attributionURL\">Nepalese base camp<\/a> by <a class=\"owner-name truncate\" title=\"Go to Mark Horrell's photostream\" href=\"https:\/\/www.flickr.com\/photos\/markhorrell\/\" data-track=\"attributionNameClick\">Mark Horrell<\/a><span style=\"text-align: initial;font-size: 1em\">\u00a0on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a\u00a0<\/span><a style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">TED-Ed. (2016, October 4). Could we survive prolonged space travel? - Lisa Nip. YouTube. https:\/\/www.youtube.com\/watch?v=upp9-w6GPhU&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2019, May 6). How this disease changes the shape of your cells - Amber M. Yates. YouTube. https:\/\/www.youtube.com\/watch?v=hRnrIpUMyZQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Weiss, H. (2007). Is there a body of evidence for the treatment of patients with Adolescent Idiopathic Scoliosis (AIS)? [Figure 2 - digital photograph],\u00a0 <i>Scoliosis, <\/i>2(19).\u00a0https:\/\/doi.org\/10.1186\/1748-7161-2-19<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3090\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3090\"><div tabindex=\"-1\"><p>Image shows a diagram of the location of the liver (large organ which sits below the diaphragm), the gallbladder (small sac-like organ which is tucked under the liver) and the pancreas (long flat organ which sits in front of and just under the stomach).<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_5941\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_5941\"><div tabindex=\"-1\"><p>The largest part of the brain that controls conscious functions such as reasoning and sight.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_5937\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_5937\"><div tabindex=\"-1\"><p>The highly folded, thin outer layer of the cerebrum where most information processing in the brain takes place.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3144\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3144\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4767\" aria-describedby=\"caption-attachment-4767\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4767\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Cliche-1.jpg\" alt=\"16.5.1 Dog peeing on fire hydrant\" width=\"400\" height=\"300\"><figcaption id=\"caption-attachment-4767\" class=\"wp-caption-text\"><em>Figure 16.5.1 Just leaving a message.....<\/em><\/figcaption><\/figure>\n<div>\n<h1>Communicating with Urine<\/h1>\n<\/div>\n<p>Why do dogs pee on fire hydrants? Besides \u201chaving to go,\u201d they are marking their territory with chemicals in their urine called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4768\">pheromone<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. It\u2019s a form of communication, in which they are \u201csaying\u201d with odors that the yard is <\/span><em style=\"text-align: initial;font-size: 1em\">theirs<\/em><span style=\"text-align: initial;font-size: 1em\">\u00a0and other dogs should stay away. In addition to fire hydrants, dogs may urinate on fence posts, trees, car tires, and many other objects. Urination in dogs, as in people, is usually a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3004\">voluntary<\/a> process controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3823\">brain<\/a>. The process of forming urine \u2014 which occurs in the kidneys \u2014 occurs constantly, and is not under voluntary control. What happens to all the urine that forms in the kidneys? It passes from the kidneys through the other organs of the urinary system, starting with the ureters.<\/span><\/p>\n<div>\n<h1>Ureters<\/h1>\n<\/div>\n<p>As shown in Figure 16.5.2, <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureter<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\"> are tube-like structures that connect the kidneys with the urinary bladder. They are paired structures, with one ureter for each kidney. In adults, ureters are between 25 and 30 cm (about 10\u201312 in) long and about 3 to 4 mm in diameter.<\/span><\/p>\n<figure id=\"attachment_4769\" aria-describedby=\"caption-attachment-4769\" style=\"width: 446px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4769\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Urinary-System-Male-1.jpg\" alt=\"16.5.2 Urinary System - Ureters\" width=\"446\" height=\"449\"><figcaption id=\"caption-attachment-4769\" class=\"wp-caption-text\"><em>16.5.2 Besides the kidneys, the urinary system includes two ureters, the urinary bladder, and the urethra.<\/em><\/figcaption><\/figure>\n<p>Each ureter arises in the pelvis of a kidney (the renal pelvis in Figure 16.5.3). It then passes down the side of the kidney, and finally enters the back of the bladder. At the entrance to the bladder, the ureters have sphincters that prevent the backflow of urine.<\/p>\n<figure id=\"attachment_4770\" aria-describedby=\"caption-attachment-4770\" style=\"width: 388px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4770\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Adrenal-glands-on-Kidney-by-NCI-Public-Domain-1-1.jpg\" alt=\"16.5.3 Renal Pelvis and Ureter\" width=\"388\" height=\"357\"><figcaption id=\"caption-attachment-4770\" class=\"wp-caption-text\"><em>16.5.3 Urine collects in the renal pelvis, which is continuous with the ureter. The ureter then carries the urine from the kidney to the urinary bladder.<\/em><\/figcaption><\/figure>\n<p>The walls of the ureters are composed of multiple layers of different types of tissues.\u00a0 The innermost layer is a special type of epithelium, called transitional epithelium. Unlike the epithelium lining most organs, transitional epithelium is capable of stretching and does not produce mucus. It lines much of the urinary system, including the renal pelvis, bladder, and much of the urethra, in addition to the ureters. Transitional epithelium allows these organs to stretch and expand as they fill with urine or allow urine to pass through. The next layer of the ureter walls is made up of loose connective tissue containing elastic fibres, nerves, and blood and lymphatic vessels. After this layer are two layers of smooth muscles, an inner circular layer, and an outer longitudinal layer. The smooth muscle layers can contract in waves of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a> to propel urine down the ureters from the kidneys to the urinary bladder. The outermost layer of the ureter walls consists of fibrous tissue.<\/p>\n<div>\n<h1>Urinary Bladder<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a><\/strong>\u00a0is a hollow, muscular, and stretchy organ that rests on the pelvic floor. It collects and stores <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a> from the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidney<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0before the urine is eliminated through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4726\">urination<\/a>. As shown in Figure 16.5.4, urine enters the urinary bladder from the ureters through two ureteral openings on either side of the back wall of the bladder. Urine leaves the bladder through a sphincter called the internal urethral sphincter. When the sphincter relaxes and opens, it allows urine to flow out of the bladder and into the urethra.<\/span><\/p>\n<figure id=\"attachment_4771\" aria-describedby=\"caption-attachment-4771\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-4771\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2605_The_Bladder-1.jpg\" alt=\"16.5.4 Urinary Bladder\" width=\"1024\" height=\"627\"><figcaption id=\"caption-attachment-4771\" class=\"wp-caption-text\"><em>Figure 16.5.4 This diagram of the urinary bladder shows (a) a cross-sectional drawing of the entire bladder and (b) a microscopic cross-section of the tissues in the wall of the bladder.<\/em><\/figcaption><\/figure>\n<p>Like the ureters, the bladder is lined with transitional epithelium, which can flatten out and stretch as needed as the bladder fills with urine. The next layer (lamina propria) is a layer of loose connective tissue, nerves, and blood and lymphatic vessels. This is followed by a submucosa layer, which connects the lining of the bladder with the detrusor muscle in the walls of the bladder. The outer covering of the bladder is peritoneum, which is a smooth layer of epithelial cells that lines the abdominal cavity and covers most abdominal organs.<\/p>\n<p>The detrusor muscle in the wall of the bladder is made of smooth muscle fibres controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3807\">autonomic<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3014\">somatic<\/a> nervous systems. As the bladder fills, the detrusor muscle automatically relaxes to allow it to hold more urine. When the bladder is about half full, the stretching of the walls triggers the sensation of needing to urinate. When the individual is ready to void, conscious nervous signals cause the detrusor muscle to contract, and the internal urethral sphincter to relax and open. As a result, urine is forcefully expelled out of the bladder and into the urethra.<\/p>\n<div>\n<h1>Urethra<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4732\">urethra<\/a><\/strong> is a tube that connects the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a> to the external urethral orifice, which is the opening of the urethra on the surface of the body. As shown in Figure 16.5.5, the urethra in males travels through the penis, so it is much longer than the urethra in females. In males, the urethra averages about 20 cm (about 7.8 in) long, whereas in females, it averages only about 4.8 cm (about 1.9 in) long. In males, the urethra carries semen (as well as urine), but in females, it carries only urine.\u00a0 In addition, in males, the urethra passes through the prostate gland (part of the reproductive system) which is absent in women.<\/p>\n<figure id=\"attachment_4772\" aria-describedby=\"caption-attachment-4772\" style=\"width: 512px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-4772\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/512px-Male_and_female_urethral_openings.svg_-1.png\" alt=\"16.5.5\" width=\"512\" height=\"355\"><figcaption id=\"caption-attachment-4772\" class=\"wp-caption-text\"><em>Figure 16.5.5 The male pelvis on the left and the female pelvis on the right. Notice how much longer the male urethra is because it travels through the length of the penis to reach the external urethral orifice.<\/em><\/figcaption><\/figure>\n<p>Like the ureters and bladder, the proximal (closer to the bladder) two-thirds of the urethra are lined with transitional epithelium. The distal (farther from the bladder) third of the urethra is lined with mucus-secreting epithelium. The mucus helps protect the epithelium from urine, which is corrosive. Below the epithelium is loose connective tissue, and below that are layers of smooth muscle that are continuous with the muscle layers of the urinary bladder. When the bladder contracts to forcefully expel urine, the smooth muscle of the urethra relaxes to allow the urine to pass through.<\/p>\n<p>In order for urine to leave the body through the external urethral orifice, the external urethral sphincter must relax and open. This sphincter is a striated muscle that is controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3014\">somatic nervous system<\/a>, so it is under conscious, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3004\">voluntary<\/a> control in most people (exceptions are infants, some elderly people, and patients with certain injuries or disorders). The muscle can be held in a contracted state and hold in the urine until the person is ready to urinate. Following urination, the smooth muscle lining the urethra automatically contracts to re-establish muscle tone, and the individual consciously contracts the external urethral sphincter to close the external urethral opening.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">Ureters<\/a>\u00a0are tube-like structures that connect the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a>\u00a0with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a>. Each ureter arises at the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a> of a kidney and travels down through the abdomen to the urinary bladder. The walls of the ureter contain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2982\">smooth muscle<\/a> that can contract to push <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a> through the ureter by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a>. The walls are lined with transitional epithelium that can expand and stretch.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a> is a hollow, muscular organ that rests on the pelvic floor. It is also lined with transitional epithelium. The function of the bladder is to collect and store urine from the kidneys before the urine is eliminated through urination. Filling of the bladder triggers the sensation of needing to urinate. When a conscious decision to urinate is made, the detrusor muscle in the bladder wall contracts and forces urine out of the bladder and into the urethra.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4732\">urethra<\/a> is a tube that connects the urinary bladder to the external urethral orifice. Somatic nerves control the sphincter at the distal end of the urethra. This allows the opening of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4627\">sphincter<\/a> for urination to be under <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3004\">voluntary<\/a> control.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What are ureters?\u00a0 Describe the location of the ureters relative to other urinary tract organs.<\/li>\n<li>Identify layers in the walls of a ureter. How do they contribute to the ureter\u2019s function?<\/li>\n<li>Describe the urinary bladder. What is the function of the urinary bladder?<\/li>\n<li>\n<div id=\"h5p-416\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-416\" class=\"h5p-iframe\" data-content-id=\"416\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"16.5 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>How does the nervous system control the urinary bladder?<\/li>\n<li>What is the urethra?<\/li>\n<li>How does the nervous system control urination?<\/li>\n<li>Identify the sphincters that are located along the pathway from the ureters to the external urethral orifice.<\/li>\n<li>What are two differences between the male and female urethra?<\/li>\n<li>When the bladder muscle contracts, the smooth muscle in the walls of the urethra _________ .<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/2Brajdazp1o<\/p>\n<p style=\"text-align: center\">The taboo secret to better health | Molly Winter, TED. 2016.<\/p>\n<p>https:\/\/youtu.be\/dg4_deyHLvQ<\/p>\n<p style=\"text-align: center\">What Happens When You Hold Your Pee? SciShow, 2016.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 16.5.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cliche.jpg\" rel=\"cc:attributionURL\">Cliche<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/people\/27735730@N00\" rel=\"nofollow\">Jackie<\/a> on Wikimedia Common s is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\" rel=\"license\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 16.5.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:UrinarySystemMale.jpg\" rel=\"cc:attributionURL\">Urinary System Male<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.5.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Kidney_and_adrenal_gland.jpg\" rel=\"cc:attributionURL\">Adrenal glands on Kidney by NCI Public Domain<\/a>\u00a0by Alan Hoofring (Illustrator) \/<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4355\">photo ID 4355<\/a>) on Wikimedia Commons is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.5.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2605_The_Bladder.jpg\" rel=\"cc:attributionURL\">2605_The_Bladder<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-2-gross-anatomy-of-urine-transport\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license. <span class=\"os-caption\"><span class=\"search-highlight text last\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">(Micrograph originally provided by <span class=\"search-highlight first text last\" data-timestamp=\"1597636975280\" data-highlight-id=\"fda2d69c-8a26-4beb-b12b-daf80f2c011d\" data-highlighted=\"true\">the<\/span>\u00a0Regents of\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975286\" data-highlight-id=\"855d8b77-088b-43c9-81b4-0e0ff4f489e1\" data-highlighted=\"true\">the<\/span> University of Michigan Medical School \u00a9 2012.)<\/span><\/span><\/p>\n<p><strong>Figure 16.5.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Male_and_female_urethral_openings.svg\" rel=\"cc:attributionURL\">512px-Male_and_female_urethral_openings.svg<\/a>\u00a0by <a title=\"User:Andrybak\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Andrybak\">andrybak<\/a> (derivative work) on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\" rel=\"license\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license. (Original: <a title=\"File:Male anatomy blank.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Male_anatomy_blank.svg\">Male anatomy blank.svg<\/a>:\u00a0<a class=\"external text\" href=\"http:\/\/www.luckymojo.com\/faqs\/altsex\/penis.html\" rel=\"nofollow\">alt.sex FAQ<\/a>, derivative work:\u00a0<a title=\"User:Tsaitgaist\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Tsaitgaist\">Tsaitgaist<\/a>\u00a0<a title=\"File:Female anatomy with g-spot.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Female_anatomy_with_g-spot.svg\">Female anatomy with g-spot.svg<\/a>:\u00a0<a title=\"User:Tsaitgaist\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Tsaitgaist\">Tsaitgaist<\/a>.)<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">25.4<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"3366\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">Bladder\u00a0<\/span><\/span><span class=\"os-caption\"><span class=\"search-highlight text last\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">(a) Anterior cross section of the bladder. (b)\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975256\" data-highlight-id=\"b7b616c9-437f-4937-a7f5-c1b47387a77e\" data-highlighted=\"true\">The<\/span>\u00a0detrusor muscle of\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975257\" data-highlight-id=\"31417372-bff6-4d54-941d-580ae31d2bcf\" data-highlighted=\"true\">the bladder<\/span> (source: monkey tissue) LM \u00d7 448 [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 7.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-2-gross-anatomy-of-urine-transport\u00a0<\/span><\/span><\/p>\n<p class=\"hanging-indent\">SciShow. (2016, January 22). What happens when you hold your pee? YouTube. https:\/\/www.youtube.com\/watch?v=dg4_deyHLvQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED. (2016, September 2). The taboo secret to better health | Molly Winter. YouTube. https:\/\/www.youtube.com\/watch?v=2Brajdazp1o&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3145\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3145\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4767\" aria-describedby=\"caption-attachment-4767\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4767\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Cliche-1.jpg\" alt=\"16.5.1 Dog peeing on fire hydrant\" width=\"400\" height=\"300\"><figcaption id=\"caption-attachment-4767\" class=\"wp-caption-text\"><em>Figure 16.5.1 Just leaving a message.....<\/em><\/figcaption><\/figure>\n<div>\n<h1>Communicating with Urine<\/h1>\n<\/div>\n<p>Why do dogs pee on fire hydrants? Besides \u201chaving to go,\u201d they are marking their territory with chemicals in their urine called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4768\">pheromone<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. It\u2019s a form of communication, in which they are \u201csaying\u201d with odors that the yard is <\/span><em style=\"text-align: initial;font-size: 1em\">theirs<\/em><span style=\"text-align: initial;font-size: 1em\">\u00a0and other dogs should stay away. In addition to fire hydrants, dogs may urinate on fence posts, trees, car tires, and many other objects. Urination in dogs, as in people, is usually a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3004\">voluntary<\/a> process controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2986\">brain<\/a>. The process of forming urine \u2014 which occurs in the kidneys \u2014 occurs constantly, and is not under voluntary control. What happens to all the urine that forms in the kidneys? It passes from the kidneys through the other organs of the urinary system, starting with the ureters.<\/span><\/p>\n<div>\n<h1>Ureters<\/h1>\n<\/div>\n<p>As shown in Figure 16.5.2, <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureter<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\"> are tube-like structures that connect the kidneys with the urinary bladder. They are paired structures, with one ureter for each kidney. In adults, ureters are between 25 and 30 cm (about 10\u201312 in) long and about 3 to 4 mm in diameter.<\/span><\/p>\n<figure id=\"attachment_4769\" aria-describedby=\"caption-attachment-4769\" style=\"width: 446px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4769\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Urinary-System-Male-1.jpg\" alt=\"16.5.2 Urinary System - Ureters\" width=\"446\" height=\"449\"><figcaption id=\"caption-attachment-4769\" class=\"wp-caption-text\"><em>16.5.2 Besides the kidneys, the urinary system includes two ureters, the urinary bladder, and the urethra.<\/em><\/figcaption><\/figure>\n<p>Each ureter arises in the pelvis of a kidney (the renal pelvis in Figure 16.5.3). It then passes down the side of the kidney, and finally enters the back of the bladder. At the entrance to the bladder, the ureters have sphincters that prevent the backflow of urine.<\/p>\n<figure id=\"attachment_4770\" aria-describedby=\"caption-attachment-4770\" style=\"width: 388px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-4770\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Adrenal-glands-on-Kidney-by-NCI-Public-Domain-1-1.jpg\" alt=\"16.5.3 Renal Pelvis and Ureter\" width=\"388\" height=\"357\"><figcaption id=\"caption-attachment-4770\" class=\"wp-caption-text\"><em>16.5.3 Urine collects in the renal pelvis, which is continuous with the ureter. The ureter then carries the urine from the kidney to the urinary bladder.<\/em><\/figcaption><\/figure>\n<p>The walls of the ureters are composed of multiple layers of different types of tissues.\u00a0 The innermost layer is a special type of epithelium, called transitional epithelium. Unlike the epithelium lining most organs, transitional epithelium is capable of stretching and does not produce mucus. It lines much of the urinary system, including the renal pelvis, bladder, and much of the urethra, in addition to the ureters. Transitional epithelium allows these organs to stretch and expand as they fill with urine or allow urine to pass through. The next layer of the ureter walls is made up of loose connective tissue containing elastic fibres, nerves, and blood and lymphatic vessels. After this layer are two layers of smooth muscles, an inner circular layer, and an outer longitudinal layer. The smooth muscle layers can contract in waves of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a> to propel urine down the ureters from the kidneys to the urinary bladder. The outermost layer of the ureter walls consists of fibrous tissue.<\/p>\n<div>\n<h1>Urinary Bladder<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a><\/strong>\u00a0is a hollow, muscular, and stretchy organ that rests on the pelvic floor. It collects and stores <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a> from the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidney<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0before the urine is eliminated through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4726\">urination<\/a>. As shown in Figure 16.5.4, urine enters the urinary bladder from the ureters through two ureteral openings on either side of the back wall of the bladder. Urine leaves the bladder through a sphincter called the internal urethral sphincter. When the sphincter relaxes and opens, it allows urine to flow out of the bladder and into the urethra.<\/span><\/p>\n<figure id=\"attachment_4771\" aria-describedby=\"caption-attachment-4771\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-4771\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2605_The_Bladder-1.jpg\" alt=\"16.5.4 Urinary Bladder\" width=\"1024\" height=\"627\"><figcaption id=\"caption-attachment-4771\" class=\"wp-caption-text\"><em>Figure 16.5.4 This diagram of the urinary bladder shows (a) a cross-sectional drawing of the entire bladder and (b) a microscopic cross-section of the tissues in the wall of the bladder.<\/em><\/figcaption><\/figure>\n<p>Like the ureters, the bladder is lined with transitional epithelium, which can flatten out and stretch as needed as the bladder fills with urine. The next layer (lamina propria) is a layer of loose connective tissue, nerves, and blood and lymphatic vessels. This is followed by a submucosa layer, which connects the lining of the bladder with the detrusor muscle in the walls of the bladder. The outer covering of the bladder is peritoneum, which is a smooth layer of epithelial cells that lines the abdominal cavity and covers most abdominal organs.<\/p>\n<p>The detrusor muscle in the wall of the bladder is made of smooth muscle fibres controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2940\">autonomic<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3014\">somatic<\/a> nervous systems. As the bladder fills, the detrusor muscle automatically relaxes to allow it to hold more urine. When the bladder is about half full, the stretching of the walls triggers the sensation of needing to urinate. When the individual is ready to void, conscious nervous signals cause the detrusor muscle to contract, and the internal urethral sphincter to relax and open. As a result, urine is forcefully expelled out of the bladder and into the urethra.<\/p>\n<div>\n<h1>Urethra<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4732\">urethra<\/a><\/strong> is a tube that connects the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a> to the external urethral orifice, which is the opening of the urethra on the surface of the body. As shown in Figure 16.5.5, the urethra in males travels through the penis, so it is much longer than the urethra in females. In males, the urethra averages about 20 cm (about 7.8 in) long, whereas in females, it averages only about 4.8 cm (about 1.9 in) long. In males, the urethra carries semen (as well as urine), but in females, it carries only urine.\u00a0 In addition, in males, the urethra passes through the prostate gland (part of the reproductive system) which is absent in women.<\/p>\n<figure id=\"attachment_4772\" aria-describedby=\"caption-attachment-4772\" style=\"width: 512px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-4772\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/512px-Male_and_female_urethral_openings.svg_-1.png\" alt=\"16.5.5\" width=\"512\" height=\"355\"><figcaption id=\"caption-attachment-4772\" class=\"wp-caption-text\"><em>Figure 16.5.5 The male pelvis on the left and the female pelvis on the right. Notice how much longer the male urethra is because it travels through the length of the penis to reach the external urethral orifice.<\/em><\/figcaption><\/figure>\n<p>Like the ureters and bladder, the proximal (closer to the bladder) two-thirds of the urethra are lined with transitional epithelium. The distal (farther from the bladder) third of the urethra is lined with mucus-secreting epithelium. The mucus helps protect the epithelium from urine, which is corrosive. Below the epithelium is loose connective tissue, and below that are layers of smooth muscle that are continuous with the muscle layers of the urinary bladder. When the bladder contracts to forcefully expel urine, the smooth muscle of the urethra relaxes to allow the urine to pass through.<\/p>\n<p>In order for urine to leave the body through the external urethral orifice, the external urethral sphincter must relax and open. This sphincter is a striated muscle that is controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3014\">somatic nervous system<\/a>, so it is under conscious, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3004\">voluntary<\/a> control in most people (exceptions are infants, some elderly people, and patients with certain injuries or disorders). The muscle can be held in a contracted state and hold in the urine until the person is ready to urinate. Following urination, the smooth muscle lining the urethra automatically contracts to re-establish muscle tone, and the individual consciously contracts the external urethral sphincter to close the external urethral opening.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">Ureters<\/a>\u00a0are tube-like structures that connect the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a>\u00a0with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a>. Each ureter arises at the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a> of a kidney and travels down through the abdomen to the urinary bladder. The walls of the ureter contain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2982\">smooth muscle<\/a> that can contract to push <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a> through the ureter by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a>. The walls are lined with transitional epithelium that can expand and stretch.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a> is a hollow, muscular organ that rests on the pelvic floor. It is also lined with transitional epithelium. The function of the bladder is to collect and store urine from the kidneys before the urine is eliminated through urination. Filling of the bladder triggers the sensation of needing to urinate. When a conscious decision to urinate is made, the detrusor muscle in the bladder wall contracts and forces urine out of the bladder and into the urethra.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4732\">urethra<\/a> is a tube that connects the urinary bladder to the external urethral orifice. Somatic nerves control the sphincter at the distal end of the urethra. This allows the opening of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4627\">sphincter<\/a> for urination to be under <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3004\">voluntary<\/a> control.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What are ureters?\u00a0 Describe the location of the ureters relative to other urinary tract organs.<\/li>\n<li>Identify layers in the walls of a ureter. How do they contribute to the ureter\u2019s function?<\/li>\n<li>Describe the urinary bladder. What is the function of the urinary bladder?<\/li>\n<li>\n<div id=\"h5p-196\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-196\" class=\"h5p-iframe\" data-content-id=\"196\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Energy Needs of Living Things\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>How does the nervous system control the urinary bladder?<\/li>\n<li>What is the urethra?<\/li>\n<li>How does the nervous system control urination?<\/li>\n<li>Identify the sphincters that are located along the pathway from the ureters to the external urethral orifice.<\/li>\n<li>What are two differences between the male and female urethra?<\/li>\n<li>When the bladder muscle contracts, the smooth muscle in the walls of the urethra _________ .<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/2Brajdazp1o<\/p>\n<p style=\"text-align: center\">The taboo secret to better health | Molly Winter, TED. 2016.<\/p>\n<p>https:\/\/youtu.be\/dg4_deyHLvQ<\/p>\n<p style=\"text-align: center\">What Happens When You Hold Your Pee? SciShow, 2016.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 16.5.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cliche.jpg\" rel=\"cc:attributionURL\">Cliche<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/people\/27735730@N00\" rel=\"nofollow\">Jackie<\/a> on Wikimedia Common s is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\" rel=\"license\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 16.5.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:UrinarySystemMale.jpg\" rel=\"cc:attributionURL\">Urinary System Male<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.5.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Kidney_and_adrenal_gland.jpg\" rel=\"cc:attributionURL\">Adrenal glands on Kidney by NCI Public Domain<\/a>\u00a0by Alan Hoofring (Illustrator) \/<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4355\">photo ID 4355<\/a>) on Wikimedia Commons is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.5.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2605_The_Bladder.jpg\" rel=\"cc:attributionURL\">2605_The_Bladder<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-2-gross-anatomy-of-urine-transport\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license. <span class=\"os-caption\"><span class=\"search-highlight text last\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">(Micrograph originally provided by <span class=\"search-highlight first text last\" data-timestamp=\"1597636975280\" data-highlight-id=\"fda2d69c-8a26-4beb-b12b-daf80f2c011d\" data-highlighted=\"true\">the<\/span>\u00a0Regents of\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975286\" data-highlight-id=\"855d8b77-088b-43c9-81b4-0e0ff4f489e1\" data-highlighted=\"true\">the<\/span> University of Michigan Medical School \u00a9 2012.)<\/span><\/span><\/p>\n<p><strong>Figure 16.5.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Male_and_female_urethral_openings.svg\" rel=\"cc:attributionURL\">512px-Male_and_female_urethral_openings.svg<\/a>\u00a0by <a title=\"User:Andrybak\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Andrybak\">andrybak<\/a> (derivative work) on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\" rel=\"license\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license. (Original: <a title=\"File:Male anatomy blank.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Male_anatomy_blank.svg\">Male anatomy blank.svg<\/a>:\u00a0<a class=\"external text\" href=\"http:\/\/www.luckymojo.com\/faqs\/altsex\/penis.html\" rel=\"nofollow\">alt.sex FAQ<\/a>, derivative work:\u00a0<a title=\"User:Tsaitgaist\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Tsaitgaist\">Tsaitgaist<\/a>\u00a0<a title=\"File:Female anatomy with g-spot.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Female_anatomy_with_g-spot.svg\">Female anatomy with g-spot.svg<\/a>:\u00a0<a title=\"User:Tsaitgaist\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Tsaitgaist\">Tsaitgaist<\/a>.)<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">25.4<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"3366\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">Bladder\u00a0<\/span><\/span><span class=\"os-caption\"><span class=\"search-highlight text last\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">(a) Anterior cross section of the bladder. (b)\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975256\" data-highlight-id=\"b7b616c9-437f-4937-a7f5-c1b47387a77e\" data-highlighted=\"true\">The<\/span>\u00a0detrusor muscle of\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975257\" data-highlight-id=\"31417372-bff6-4d54-941d-580ae31d2bcf\" data-highlighted=\"true\">the bladder<\/span> (source: monkey tissue) LM \u00d7 448 [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 7.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-2-gross-anatomy-of-urine-transport\u00a0<\/span><\/span><\/p>\n<p class=\"hanging-indent\">SciShow. (2016, January 22). What happens when you hold your pee? YouTube. https:\/\/www.youtube.com\/watch?v=dg4_deyHLvQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED. (2016, September 2). The taboo secret to better health | Molly Winter. YouTube. https:\/\/www.youtube.com\/watch?v=2Brajdazp1o&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3151\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3151\"><div tabindex=\"-1\"><p>Image shows a diagram of the kidney with several kidney stones, which have accumulated in the renal pelvis and are blocking the exit to the ureter.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_5977\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_5977\"><div tabindex=\"-1\"><p>A special sensory organ that collects and amplifies sound waves and information on body position and transforms them into nerve impulses that travel to the brain.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_5949\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_5949\"><div tabindex=\"-1\"><p>A coiled, fluid-filled tube in the inner ear that changes mechanical sound vibrations and positional information to nerve impulses that travel to the brain.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3155\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3155\"><div tabindex=\"-1\"><p>Image shows  a photograph of several wine bottles on a shelf.  The image has been deliberately blurred to simulate the effects of drunkeness.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3156\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3156\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4799\" aria-describedby=\"caption-attachment-4799\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4799\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/alcohol-64164_1920-1.jpg\" alt=\"16.7.1\" width=\"400\" height=\"300\"><figcaption id=\"caption-attachment-4799\" class=\"wp-caption-text\"><em>Figure 16.7.1 Alcoholic affects.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Case Study Conclusion: Drink and Flush<\/h1>\n<\/div>\n<p>You are probably aware that,\u00a0because of its effects on the brain,\u00a0drinking alcohol can cause visual disturbances, slurred speech, drowsiness, impaired judgment, and loss of coordination. Although it may be less obvious, alcohol also can have serious effects on the functioning of the excretory system.<\/p>\n<p>As you learned from the conversation between Talia and Shae \u2014 who were in line for the restroom at the beginning of this chapter \u2014 alcohol consumption inhibits a hormone that causes our bodies to retain water. As a result, more water is released in urine, increasing the frequency of restroom trips, as well as the risk of dehydration.<\/p>\n<p>Which hormone discussed in this chapter does this? If you answered <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3801\">antidiuretic hormone<\/a> (ADH; also called vasopressin) \u2014 you are correct! ADH is secreted by the\u00a0posterior <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2938\">pituitary gland<\/a>\u00a0and acts on the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidney<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. As you have learned, the kidneys filter the blood, reabsorb needed substances, and produce <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>. ADH helps the body conserve water by influencing this process. ADH makes the collecting ducts in the kidneys permeable to water, allowing water molecules to be reabsorbed from the urine back into the blood through osmosis into capillaries.<\/span><\/p>\n<p>Alcohol is thought to produce more dilute urine by inhibiting the release of ADH. This causes the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4759\">collecting duct<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0to be more impermeable to water, so less water can be reabsorbed, and more is excreted in urine. Because the volume of urine is increased, the bladder fills up more quickly, and the urge to urinate occurs more frequently. This is part of the reason why you often see a long line for the restroom in situations where many people are drinking alcohol. In addition to producing more dilute urine, simply consuming many beverages can also increase urine output.<\/span><\/p>\n<p>In most cases, moderate drinking causes only a minor and temporary effect on kidney function. However, when people consume a large quantity of alcohol in a short period of time, or abuse alcohol over long time periods, there can be serious effects on the kidney.\u00a0Binge drinking (consuming\u00a0roughly\u00a0four to five drinks in two hours) can cause a condition called \u201cacute kidney injury,\u201d a serious and sudden impairment of kidney function that requires immediate medical attention. As with the other cases of kidney failure that you learned about in this chapter, the treatment is to artificially filter the blood using <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4783\">hemodialysis<\/a>. While normal kidney function may eventually return, acute kidney injury can sometimes cause long-term damage to the kidneys.<\/p>\n<p>In cases where people abuse alcohol, particularly for an extended period of time, there can be many serious effects on the kidneys and other parts of the excretory system. The dehydrating effect of alcohol on the body can impair the function of many organs, including the kidneys themselves. Additionally, because of alcohol\u2019s effect on kidney function, water balance, and ion balance, chronic alcohol consumption can cause abnormalities in blood ion concentration and acid-base balance, which can be very dangerous.<\/p>\n<p>Drinking more than two alcoholic beverages a day can increase your risk for high blood pressure, too. As you have learned, high blood pressure is a risk factor for some kidney disorders, as well as a common cause of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4782\">kidney failure<\/a>.\u00a0Drinking too much alcohol can damage the kidneys by raising blood pressure.<\/p>\n<p>Finally, chronic excessive consumption of alcohol can cause liver disease. The liver is an important organ of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3907\">excretory system<\/a> that breaks down toxic substances in the blood. The liver and kidneys work together to remove wastes from the bloodstream. You may remember, for example, the liver transforms <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4707\">ammonia<\/a> into <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, which is then filtered and excreted by the kidneys. When the liver is not functioning normally, it puts added strain on the kidneys, which can result in kidney dysfunction. This association between alcohol, liver disease, and kidney dysfunction is so strong that most of the patients in Canada with both liver disease and related kidney dysfunction are alcoholics.<\/p>\n<p>As you have learned, the excretory system is essential\u00a0in\u00a0removing toxic wastes from the body and regulating homeostasis. Having an occasional drink can temporarily alter these functions, but excessive alcohol exposure can seriously and permanently damage this system in many ways. Limiting alcohol consumption can help preserve the normal functioning of the excretory system, so that it can protect your health.<\/p>\n<div>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter 16 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In this chapter you learned about the excretory system. Specifically, you learned that:<\/p>\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4705\">Excretion<\/a> is the process of removing wastes and excess water from the body. It is an essential process in all living things, and a major way in which the human body maintains <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3669\">homeostasis<\/a>.<\/li>\n<li>Organs of the excretory system include the skin, liver, large intestine, lungs, and kidneys.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3521\">skin<\/a> plays a role in excretion through the production of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4711\">sweat<\/a> by sweat glands. Sweating eliminates excess water and salts, as well as a small amount of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, a byproduct of protein <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3629\">catabolism<\/a>.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2989\">liver<\/a> is a very important organ of excretion. The liver breaks down many substances \u2014 including toxins \u2014 in the blood. The liver also excretes <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4715\">bilirubin<\/a> (a waste product of hemoglobin catabolism) in bile. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4599\">Bile<\/a> then travels to the small intestine and is eventually excreted in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4636\">feces<\/a> by the large intestine.<\/li>\n<li>The main excretory function of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4560\">large intestine<\/a> is to eliminate solid waste that remains after food is digested and water is extracted from the indigestible matter. The large intestine also collects and excretes wastes from throughout the body.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2990\">lungs<\/a> are responsible for the excretion of gaseous wastes \u2014 primarily carbon dioxide \u2014 from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3633\">cellular respiration<\/a> in cells throughout the body. Exhaled air also contains water vapor and trace levels of some other waste gases.<\/li>\n<\/ul>\n<\/li>\n<li>The paired <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a>\u00a0are often considered the main organs of excretion. Their primary function is the elimination of excess water and wastes from the bloodstream by the production of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>. The kidneys filter many substances out of blood, allow the blood to reabsorb needed materials, and use the remaining materials to form urine.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>The two bean-shaped kidneys are located high in the back of the abdominal cavity on either side of the spine. A renal artery connects each kidney with the aorta, and transports unfiltered blood to the kidney. A renal vein connects each kidney with the inferior vena cava and transports filtered blood back to the circulation.<\/li>\n<li>The kidney has two main layers involved in the filtration of blood and formation of urine: the outer cortex and inner medulla. At least a million <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephrons<\/a>\u00a0\u2014 which are the tiny functional units of the kidney \u2014 span the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4741\">cortex<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4742\">medulla<\/a>. The entire kidney is surrounded by a fibrous capsule and protective fat layers.<\/li>\n<li>As blood flows through a nephron, many materials are filtered out of the blood, needed materials are returned to the blood, and the remaining materials are used to form urine.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>In each nephron, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4747\">glomerulus<\/a> and the surrounding <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4748\">glomerular capsule<\/a> form the unit that filters blood. From the glomerular capsule, the material filtered from blood (called filtrate) passes through the long <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4749\">renal tubule<\/a>. As it does, some substances are reabsorbed into the blood, and other substances are secreted from the blood into the filtrate, finally forming urine. The urine empties into collecting ducts, where more water may be reabsorbed.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>The kidneys are part of the urinary system, which also includes the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureters<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4732\">urethra<\/a>. The main function of the urinary system is to eliminate the waste products of metabolism from the body by forming and excreting urine. After urine forms in the kidneys, it is transported through the ureters to the bladder. The bladder stores the urine until urination, when urine is transported by the urethra to be excreted outside the body.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Besides the elimination of waste products such as urea, uric acid, excess water, and mineral ions, the urinary system has other vital functions. These include maintaining <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3669\">homeostasis<\/a> of mineral ions in extracellular fluid, regulating acid-base balance in the blood, regulating the volume of extracellular fluids, and controlling blood pressure.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>The formation of urine must be closely regulated to maintain body-wide homeostasis. Several endocrine hormones help control this function of the urinary system, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3801\">antidiuretic hormone<\/a> secreted from the posterior pituitary gland, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3467\">parathyroid hormone<\/a> from the parathyroid glands, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3789\">aldosterone<\/a> from the adrenal glands.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>For example, the kidneys are part of the renin-angiotensin-aldosterone system that regulates the concentration of sodium in the blood to control blood pressure. In this system, the enzyme renin secreted by the kidneys works with hormones from the liver and adrenal gland to stimulate nephrons to reabsorb more sodium and water from urine.<\/li>\n<\/ul>\n<\/li>\n<li>The kidneys also secrete endocrine hormones, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4763\">calcitriol<\/a> \u2014 which helps control the level of calcium in the blood \u2014 and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4764\">erythropoietin<\/a>, which stimulates bone marrow to produce red blood cells.<\/li>\n<\/ul>\n<\/li>\n<li>The process of urination is controlled by both the autonomic and the somatic nervous systems. The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3807\">autonomic system<\/a> causes the detrusor muscle in the bladder wall to relax as the bladder fills with urine, but conscious contraction of the detrusor muscle expels urine from the bladder during urination.<\/li>\n<li>Ureters are tube-like structures that connect the kidneys with the urinary bladder. Each ureter arises at the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a> of a kidney and travels down through the abdomen to the urinary bladder. The walls of the ureter contain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2982\">smooth muscle<\/a> that can contract to push urine through the ureter by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a>. The walls are lined with transitional epithelium that can expand and stretch.<\/li>\n<li>The urinary bladder is a hollow, muscular organ that rests on the pelvic floor. It is also lined with transitional epithelium. The function of the bladder is to collect and store urine from the kidneys before the urine is eliminated through urination. Filling of the bladder triggers the autonomic nervous system to stimulate the detrusor muscle in the bladder wall to contract. This forces urine out of the bladder and into the urethra.<\/li>\n<li>The urethra is a tube that connects the urinary bladder to the external urethral orifice. Somatic nerves control the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4627\">sphincter<\/a> at the distal end of the urethra. This allows the opening of the sphincter for urination to be under voluntary control.<\/li>\n<\/ul>\n<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4778\">Diabetic nephropathy<\/a> is a progressive kidney disease caused by damage to the capillaries in the glomeruli of the kidneys due to long-standing diabetes mellitus. Years of capillary damage may occur before symptoms first appear.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4780\">Polycystic kidney disease<\/a> (PKD) is a genetic disorder (autosomal dominant or recessive) in which multiple abnormal cysts grow in the kidneys.<\/li>\n<li>Diabetic nephropathy, PKD, or chronic hypertension may lead to kidney failure, in which the kidneys are no longer able to adequately filter metabolic wastes from the blood. Kidneys may fail to such a degree that kidney transplantation or repeated, frequent <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4783\">hemodialysis<\/a> is needed to support life. In hemodialysis, the patient\u2019s blood is filtered artificially through a machine and then returned to the patient\u2019s circulation.<\/li>\n<li>A kidney stone is a solid crystal that forms in a kidney from minerals in urine. A small stone may pass undetected through the ureters and the rest of the urinary tract. A larger stone may cause pain when it passes or be too large to pass, causing blockage of a ureter. Large kidney stones may be shattered with high-intensity ultrasound into pieces small enough to pass through the urinary tract, or they may be removed surgically.<\/li>\n<li>A bladder infection is generally caused by bacteria that reach the bladder from the GI tract and multiply. Bladder infections are much more common in females than males because the female urethra is much shorter and closer to the anus. Treatment generally includes antibiotic drugs.<\/li>\n<li>Urinary incontinence is a chronic problem of uncontrolled leakage of urine. It is very common, especially at older ages and in women. In men, urinary incontinence is usually caused by an enlarged prostate gland. In women, it is usually caused by stretching of pelvic floor muscles during childbirth (stress incontinence) or by an \u201coveractive bladder\u201d that empties without warning (urge incontinence).<\/li>\n<\/ul>\n<p>You have learned that,\u00a0through the removal of toxic wastes and the maintenance of homeostasis,\u00a0the excretory system protects your body. But how does your body protect itself against pathogens and other threats? Read the next chapter on the immune system to find out.<\/p>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter 16 Review<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>&nbsp;<\/p>\n<ol>\n<li>\n<div id=\"h5p-418\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-418\" class=\"h5p-iframe\" data-content-id=\"418\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Chapter 16 Review\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>In what ways can the alveoli of the lungs be considered analogous to the nephrons of the kidney?<\/li>\n<li>What is urea?\u00a0Where is urea produced, and what is it produced from?\u00a0How is urea excreted from the body?<\/li>\n<li>If a person has a large kidney stone preventing\u00a0urine that has left the kidney from reaching the bladder, where do you think this kidney stone is located? Explain your answer.<\/li>\n<li>As it relates to urine production, explain what is meant by \u201cExcretion = Filtration \u2013 Reabsorption + Secretion.\"<\/li>\n<li>Which disease discussed in the chapter specifically affects the glomerular capillaries of the kidneys?\u00a0Where are the glomerular capillaries located within the kidneys, and what is their function?<\/li>\n<li>Describe one way in which the excretory system helps maintain homeostasis in the body.<\/li>\n<li>High blood pressure can both contribute to the development of kidney disorders and be a symptom of kidney disorders.\u00a0What is a kidney disorder that can be caused by high blood pressure?\u00a0What is a kidney disorder that has high blood pressure as a symptom?\u00a0How does blood pressure generally relate to the function of the kidney?<\/li>\n<li>If the body is dehydrated, what do the kidneys do? What does this do to the appearance of the urine produced?<\/li>\n<li>Identify three risk factors for the development of kidney stones.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<h2>Attribution<\/h2>\n<p><strong>Figure 16.7.1<\/strong><\/p>\n<p><a href=\"https:\/\/pixabay.com\/photos\/alcohol-drink-alkolismus-bottles-64164\/\" rel=\"cc:attributionURL\">Tags: Alcohol Drink Alkolismus Bottles Glass Container<\/a> by Gerd Altmann [<a class=\"hover_opacity\" href=\"https:\/\/pixabay.com\/users\/geralt-9301\/\">geralt]<\/a> on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/p>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3157\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3157\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4799\" aria-describedby=\"caption-attachment-4799\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4799\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/alcohol-64164_1920-1.jpg\" alt=\"16.7.1\" width=\"400\" height=\"300\"><figcaption id=\"caption-attachment-4799\" class=\"wp-caption-text\"><em>Figure 16.7.1 Alcoholic affects.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Case Study Conclusion: Drink and Flush<\/h1>\n<\/div>\n<p>You are probably aware that,\u00a0because of its effects on the brain,\u00a0drinking alcohol can cause visual disturbances, slurred speech, drowsiness, impaired judgment, and loss of coordination. Although it may be less obvious, alcohol also can have serious effects on the functioning of the excretory system.<\/p>\n<p>As you learned from the conversation between Talia and Shae \u2014 who were in line for the restroom at the beginning of this chapter \u2014 alcohol consumption inhibits a hormone that causes our bodies to retain water. As a result, more water is released in urine, increasing the frequency of restroom trips, as well as the risk of dehydration.<\/p>\n<p>Which hormone discussed in this chapter does this? If you answered <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3094\">antidiuretic hormone<\/a> (ADH; also called vasopressin) \u2014 you are correct! ADH is secreted by the\u00a0posterior <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2938\">pituitary gland<\/a>\u00a0and acts on the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidney<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. As you have learned, the kidneys filter the blood, reabsorb needed substances, and produce <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>. ADH helps the body conserve water by influencing this process. ADH makes the collecting ducts in the kidneys permeable to water, allowing water molecules to be reabsorbed from the urine back into the blood through osmosis into capillaries.<\/span><\/p>\n<p>Alcohol is thought to produce more dilute urine by inhibiting the release of ADH. This causes the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4759\">collecting duct<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0to be more impermeable to water, so less water can be reabsorbed, and more is excreted in urine. Because the volume of urine is increased, the bladder fills up more quickly, and the urge to urinate occurs more frequently. This is part of the reason why you often see a long line for the restroom in situations where many people are drinking alcohol. In addition to producing more dilute urine, simply consuming many beverages can also increase urine output.<\/span><\/p>\n<p>In most cases, moderate drinking causes only a minor and temporary effect on kidney function. However, when people consume a large quantity of alcohol in a short period of time, or abuse alcohol over long time periods, there can be serious effects on the kidney.\u00a0Binge drinking (consuming\u00a0roughly\u00a0four to five drinks in two hours) can cause a condition called \u201cacute kidney injury,\u201d a serious and sudden impairment of kidney function that requires immediate medical attention. As with the other cases of kidney failure that you learned about in this chapter, the treatment is to artificially filter the blood using <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4783\">hemodialysis<\/a>. While normal kidney function may eventually return, acute kidney injury can sometimes cause long-term damage to the kidneys.<\/p>\n<p>In cases where people abuse alcohol, particularly for an extended period of time, there can be many serious effects on the kidneys and other parts of the excretory system. The dehydrating effect of alcohol on the body can impair the function of many organs, including the kidneys themselves. Additionally, because of alcohol\u2019s effect on kidney function, water balance, and ion balance, chronic alcohol consumption can cause abnormalities in blood ion concentration and acid-base balance, which can be very dangerous.<\/p>\n<p>Drinking more than two alcoholic beverages a day can increase your risk for high blood pressure, too. As you have learned, high blood pressure is a risk factor for some kidney disorders, as well as a common cause of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4782\">kidney failure<\/a>.\u00a0Drinking too much alcohol can damage the kidneys by raising blood pressure.<\/p>\n<p>Finally, chronic excessive consumption of alcohol can cause liver disease. The liver is an important organ of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2915\">excretory system<\/a> that breaks down toxic substances in the blood. The liver and kidneys work together to remove wastes from the bloodstream. You may remember, for example, the liver transforms <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4707\">ammonia<\/a> into <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, which is then filtered and excreted by the kidneys. When the liver is not functioning normally, it puts added strain on the kidneys, which can result in kidney dysfunction. This association between alcohol, liver disease, and kidney dysfunction is so strong that most of the patients in Canada with both liver disease and related kidney dysfunction are alcoholics.<\/p>\n<p>As you have learned, the excretory system is essential\u00a0in\u00a0removing toxic wastes from the body and regulating homeostasis. Having an occasional drink can temporarily alter these functions, but excessive alcohol exposure can seriously and permanently damage this system in many ways. Limiting alcohol consumption can help preserve the normal functioning of the excretory system, so that it can protect your health.<\/p>\n<div>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter 16 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In this chapter you learned about the excretory system. Specifically, you learned that:<\/p>\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4705\">Excretion<\/a> is the process of removing wastes and excess water from the body. It is an essential process in all living things, and a major way in which the human body maintains <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a>.<\/li>\n<li>Organs of the excretory system include the skin, liver, large intestine, lungs, and kidneys.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3521\">skin<\/a> plays a role in excretion through the production of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4711\">sweat<\/a> by sweat glands. Sweating eliminates excess water and salts, as well as a small amount of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4708\">urea<\/a>, a byproduct of protein <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_178\">catabolism<\/a>.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2989\">liver<\/a> is a very important organ of excretion. The liver breaks down many substances \u2014 including toxins \u2014 in the blood. The liver also excretes <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4715\">bilirubin<\/a> (a waste product of hemoglobin catabolism) in bile. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4599\">Bile<\/a> then travels to the small intestine and is eventually excreted in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4636\">feces<\/a> by the large intestine.<\/li>\n<li>The main excretory function of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4560\">large intestine<\/a> is to eliminate solid waste that remains after food is digested and water is extracted from the indigestible matter. The large intestine also collects and excretes wastes from throughout the body.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2990\">lungs<\/a> are responsible for the excretion of gaseous wastes \u2014 primarily carbon dioxide \u2014 from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1172\">cellular respiration<\/a> in cells throughout the body. Exhaled air also contains water vapor and trace levels of some other waste gases.<\/li>\n<\/ul>\n<\/li>\n<li>The paired <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2988\">kidneys<\/a>\u00a0are often considered the main organs of excretion. Their primary function is the elimination of excess water and wastes from the bloodstream by the production of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4717\">urine<\/a>. The kidneys filter many substances out of blood, allow the blood to reabsorb needed materials, and use the remaining materials to form urine.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>The two bean-shaped kidneys are located high in the back of the abdominal cavity on either side of the spine. A renal artery connects each kidney with the aorta, and transports unfiltered blood to the kidney. A renal vein connects each kidney with the inferior vena cava and transports filtered blood back to the circulation.<\/li>\n<li>The kidney has two main layers involved in the filtration of blood and formation of urine: the outer cortex and inner medulla. At least a million <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4718\">nephrons<\/a>\u00a0\u2014 which are the tiny functional units of the kidney \u2014 span the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4741\">cortex<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4742\">medulla<\/a>. The entire kidney is surrounded by a fibrous capsule and protective fat layers.<\/li>\n<li>As blood flows through a nephron, many materials are filtered out of the blood, needed materials are returned to the blood, and the remaining materials are used to form urine.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>In each nephron, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4747\">glomerulus<\/a> and the surrounding <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4748\">glomerular capsule<\/a> form the unit that filters blood. From the glomerular capsule, the material filtered from blood (called filtrate) passes through the long <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4749\">renal tubule<\/a>. As it does, some substances are reabsorbed into the blood, and other substances are secreted from the blood into the filtrate, finally forming urine. The urine empties into collecting ducts, where more water may be reabsorbed.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>The kidneys are part of the urinary system, which also includes the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4725\">ureters<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4731\">urinary bladder<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4732\">urethra<\/a>. The main function of the urinary system is to eliminate the waste products of metabolism from the body by forming and excreting urine. After urine forms in the kidneys, it is transported through the ureters to the bladder. The bladder stores the urine until urination, when urine is transported by the urethra to be excreted outside the body.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Besides the elimination of waste products such as urea, uric acid, excess water, and mineral ions, the urinary system has other vital functions. These include maintaining <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_173\">homeostasis<\/a> of mineral ions in extracellular fluid, regulating acid-base balance in the blood, regulating the volume of extracellular fluids, and controlling blood pressure.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>The formation of urine must be closely regulated to maintain body-wide homeostasis. Several endocrine hormones help control this function of the urinary system, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3094\">antidiuretic hormone<\/a> secreted from the posterior pituitary gland, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3467\">parathyroid hormone<\/a> from the parathyroid glands, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3406\">aldosterone<\/a> from the adrenal glands.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>For example, the kidneys are part of the renin-angiotensin-aldosterone system that regulates the concentration of sodium in the blood to control blood pressure. In this system, the enzyme renin secreted by the kidneys works with hormones from the liver and adrenal gland to stimulate nephrons to reabsorb more sodium and water from urine.<\/li>\n<\/ul>\n<\/li>\n<li>The kidneys also secrete endocrine hormones, including <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4763\">calcitriol<\/a> \u2014 which helps control the level of calcium in the blood \u2014 and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4764\">erythropoietin<\/a>, which stimulates bone marrow to produce red blood cells.<\/li>\n<\/ul>\n<\/li>\n<li>The process of urination is controlled by both the autonomic and the somatic nervous systems. The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2940\">autonomic system<\/a> causes the detrusor muscle in the bladder wall to relax as the bladder fills with urine, but conscious contraction of the detrusor muscle expels urine from the bladder during urination.<\/li>\n<li>Ureters are tube-like structures that connect the kidneys with the urinary bladder. Each ureter arises at the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4724\">renal pelvis<\/a> of a kidney and travels down through the abdomen to the urinary bladder. The walls of the ureter contain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2982\">smooth muscle<\/a> that can contract to push urine through the ureter by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2890\">peristalsis<\/a>. The walls are lined with transitional epithelium that can expand and stretch.<\/li>\n<li>The urinary bladder is a hollow, muscular organ that rests on the pelvic floor. It is also lined with transitional epithelium. The function of the bladder is to collect and store urine from the kidneys before the urine is eliminated through urination. Filling of the bladder triggers the autonomic nervous system to stimulate the detrusor muscle in the bladder wall to contract. This forces urine out of the bladder and into the urethra.<\/li>\n<li>The urethra is a tube that connects the urinary bladder to the external urethral orifice. Somatic nerves control the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4627\">sphincter<\/a> at the distal end of the urethra. This allows the opening of the sphincter for urination to be under voluntary control.<\/li>\n<\/ul>\n<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4778\">Diabetic nephropathy<\/a> is a progressive kidney disease caused by damage to the capillaries in the glomeruli of the kidneys due to long-standing diabetes mellitus. Years of capillary damage may occur before symptoms first appear.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4780\">Polycystic kidney disease<\/a> (PKD) is a genetic disorder (autosomal dominant or recessive) in which multiple abnormal cysts grow in the kidneys.<\/li>\n<li>Diabetic nephropathy, PKD, or chronic hypertension may lead to kidney failure, in which the kidneys are no longer able to adequately filter metabolic wastes from the blood. Kidneys may fail to such a degree that kidney transplantation or repeated, frequent <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4783\">hemodialysis<\/a> is needed to support life. In hemodialysis, the patient\u2019s blood is filtered artificially through a machine and then returned to the patient\u2019s circulation.<\/li>\n<li>A kidney stone is a solid crystal that forms in a kidney from minerals in urine. A small stone may pass undetected through the ureters and the rest of the urinary tract. A larger stone may cause pain when it passes or be too large to pass, causing blockage of a ureter. Large kidney stones may be shattered with high-intensity ultrasound into pieces small enough to pass through the urinary tract, or they may be removed surgically.<\/li>\n<li>A bladder infection is generally caused by bacteria that reach the bladder from the GI tract and multiply. Bladder infections are much more common in females than males because the female urethra is much shorter and closer to the anus. Treatment generally includes antibiotic drugs.<\/li>\n<li>Urinary incontinence is a chronic problem of uncontrolled leakage of urine. It is very common, especially at older ages and in women. In men, urinary incontinence is usually caused by an enlarged prostate gland. In women, it is usually caused by stretching of pelvic floor muscles during childbirth (stress incontinence) or by an \u201coveractive bladder\u201d that empties without warning (urge incontinence).<\/li>\n<\/ul>\n<p>You have learned that,\u00a0through the removal of toxic wastes and the maintenance of homeostasis,\u00a0the excretory system protects your body. But how does your body protect itself against pathogens and other threats? Read the next chapter on the immune system to find out.<\/p>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter 16 Review<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>&nbsp;<\/p>\n<ol>\n<li>\n<div id=\"h5p-198\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-198\" class=\"h5p-iframe\" data-content-id=\"198\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"11.3 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>In what ways can the alveoli of the lungs be considered analogous to the nephrons of the kidney?<\/li>\n<li>What is urea?\u00a0Where is urea produced, and what is it produced from?\u00a0How is urea excreted from the body?<\/li>\n<li>If a person has a large kidney stone preventing\u00a0urine that has left the kidney from reaching the bladder, where do you think this kidney stone is located? Explain your answer.<\/li>\n<li>As it relates to urine production, explain what is meant by \u201cExcretion = Filtration \u2013 Reabsorption + Secretion.\"<\/li>\n<li>Which disease discussed in the chapter specifically affects the glomerular capillaries of the kidneys?\u00a0Where are the glomerular capillaries located within the kidneys, and what is their function?<\/li>\n<li>Describe one way in which the excretory system helps maintain homeostasis in the body.<\/li>\n<li>High blood pressure can both contribute to the development of kidney disorders and be a symptom of kidney disorders.\u00a0What is a kidney disorder that can be caused by high blood pressure?\u00a0What is a kidney disorder that has high blood pressure as a symptom?\u00a0How does blood pressure generally relate to the function of the kidney?<\/li>\n<li>If the body is dehydrated, what do the kidneys do? What does this do to the appearance of the urine produced?<\/li>\n<li>Identify three risk factors for the development of kidney stones.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<h2>Attribution<\/h2>\n<p><strong>Figure 16.7.1<\/strong><\/p>\n<p><a href=\"https:\/\/pixabay.com\/photos\/alcohol-drink-alkolismus-bottles-64164\/\" rel=\"cc:attributionURL\">Tags: Alcohol Drink Alkolismus Bottles Glass Container<\/a> by Gerd Altmann [<a class=\"hover_opacity\" href=\"https:\/\/pixabay.com\/users\/geralt-9301\/\">geralt]<\/a> on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/p>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3158\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3158\"><div tabindex=\"-1\"><\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3159\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3159\"><div tabindex=\"-1\"><\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3160\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3160\"><div tabindex=\"-1\"><p>Image shows a female doctor checking the lymph nodes in the neck of a patient.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3163\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3163\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4803\" aria-describedby=\"caption-attachment-4803\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4803\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Lymph-nodes-1.png\" alt=\"17.1.1 Checking Lymph Nodes\" width=\"400\" height=\"380\"><figcaption id=\"caption-attachment-4803\" class=\"wp-caption-text\"><em>Figure 17.1.1 Health practitioners will often check your lymph nodes for unusual lumps.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Case Study: Defending Your Defenses<\/h1>\n<\/div>\n<figure id=\"attachment_4807\" aria-describedby=\"caption-attachment-4807\" style=\"width: 291px\" class=\"wp-caption alignright\"><img class=\" wp-image-4807\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/mitchell-luo-ymo_yC_N_2o-unsplash-scaled-2.jpg\" alt=\"17.1.2 Hakeem\" width=\"291\" height=\"437\"><figcaption id=\"caption-attachment-4807\" class=\"wp-caption-text\"><em>Figure 17.1.2 Hakeem is concerned about his health - he has been unusually tired, has been losing weight and most recently, found an unexpected lump on the side of his neck.<\/em><\/figcaption><\/figure>\n<p>Twenty-six-year-old Hakeem wasn\u2019t feeling well. He was more tired than usual, dragging through his workdays despite going to bed earlier, and napping on the weekends. He didn\u2019t have much of an appetite, and had started losing weight. When he pressed on the side of his neck, like the doctor is doing in Figure 17.1.1, he noticed an unusual lump.<\/p>\n<p>Hakeem went to his doctor, who performed a physical exam and determined that the lump was a swollen lymph node. Lymph nodes are part of the immune system, and they will often become enlarged when the body is fighting off an infection. Dr. Hayes thinks that the swollen lymph node and fatigue could be signs of a viral or bacterial infection, although he is concerned about Hakeem\u2019s lack of appetite and weight loss. All of those symptoms combined can indicate a type of cancer called lymphoma. An infection, however, is a more likely cause, particularly in a young person like Hakeem. Dr. Hayes prescribes an antibiotic in case Hakeem has a bacterial infection, and advises him to return in a few weeks if his lymph node does not shrink, or if he is not feeling better.<\/p>\n<p>Hakeem returns a few weeks later. He is not feeling better and his lymph node is still enlarged. Dr. Hayes is concerned, and orders a biopsy of the enlarged lymph node. A lymph node biopsy for suspected lymphoma often involves the surgical removal of all or part of a lymph node. This helps to determine whether the tissue contains cancerous cells.<\/p>\n<figure id=\"attachment_4808\" aria-describedby=\"caption-attachment-4808\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4808\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lymph-node-biopsy-by-US-Army-in-Africa-on-Flickr-1.jpg\" alt=\"17.1.3 Lymph Node Biopsy\" width=\"400\" height=\"314\"><figcaption id=\"caption-attachment-4808\" class=\"wp-caption-text\"><em>Figure 17.1.3 Surgeons performing a lymph node biopsy.<\/em><\/figcaption><\/figure>\n<p>The initial results of the biopsy indicate that Hakeem does have lymphoma. Although lymphoma is more common in older people, young adults and even children can get this disease. There are many types of lymphoma, with the two main types being <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/hodgkins-lymphoma\/symptoms-causes\/syc-20352646\">Hodgkin's lymphoma<\/a> and <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/non-hodgkins-lymphoma\/symptoms-causes\/syc-20375680\">non-Hodgkin's lymphoma<\/a>. Non-Hodgkin lymphoma (NHL), in turn, has many subtypes. The subtype depends on several factors, including which cell types are affected. Some subtypes of NHL, for example, affect immune system cells called B cells, while others affect different immune system cells called T cells.<\/p>\n<p>Dr. Hayes explains to Hakeem that it is important to determine which type of lymphoma he has, in order to choose the best course of treatment. Hakeem\u2019s biopsied tissue will be further examined and tested to see which cell types are affected, as well as which specific cell-surface proteins \u2014 called antigens \u2014 are present. This should help identify his specific type of lymphoma.<\/p>\n<p>As you read this chapter, you will learn about the functions of the immune system, and the specific roles that its cells and organs \u2014 such as B and T cells and lymph nodes \u2014 play in defending the body. At the end of this chapter, you will learn what type of lymphoma Hakeem has and what some of his treatment options are, including treatments that make use of the biochemistry of the immune system to fight cancer with the immune system itself.<\/p>\n<div>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter Overview: Immune System<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In this chapter, you will learn about the immune system \u2014 the system that defends the body against infections and other causes of disease, such as cancerous cells. Specifically, you will learn about:<\/p>\n<ul>\n<li>How the immune system identifies normal cells of the body as \u201cself\u201d and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3707\">pathogens<\/a> and damaged cells as \u201cnon-self.\u201d<\/li>\n<li>The two major subsystems of the general immune system: the innate immune system \u2014 which provides a quick, but non-specific response \u2014 and the adaptive immune system, which is slower, but provides a specific response that often results in long-lasting immunity.<\/li>\n<li>The specialized immune system that protects the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3823\">brain<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3010\">spinal cord<\/a>, called the neuroimmune system.<\/li>\n<li>The organs, cells, and responses of the innate immune system, which includes physical barriers (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3521\">skin<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4571\">mucus<\/a>), chemical and biological barriers, inflammation, activation of the complement system of molecules, and non-specific cellular responses (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1680\">phagocytosis<\/a>).<\/li>\n<li>The lymphatic system \u2014 which includes white blood cells called lymphocytes, lymphatic vessels (which transport a fluid called lymph), and organs (such as the spleen, tonsils, and lymph nodes) \u2014 and its important role in the adaptive immune system.<\/li>\n<li>Specific cells of the immune system and their functions, including B cells, T cells, plasma cells, and natural killer cells.<\/li>\n<li>How the adaptive immune system can generate specific and often long-lasting immunity against pathogens through the production of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3567\">antibodies<\/a>.<\/li>\n<li>How vaccines work to generate immunity.<\/li>\n<li>How cells in the immune system detect and kill cancerous cells.<\/li>\n<li>Some strategies that pathogens employ to evade the immune system.<\/li>\n<li>Disorders of the immune system, including allergies, autoimmune diseases (such as diabetes and multiple sclerosis), and immunodeficiency resulting from conditions such as HIV infection.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox shaded\">\n<p>As you read the chapter, think about the following questions:<\/p>\n<ol>\n<li>What are the functions of lymph nodes?<\/li>\n<li>What are B and T cells? How do they relate to lymph nodes?<\/li>\n<li>What are cell-surface antigens? How do they relate to the immune system and to cancer?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 17.1.1<\/strong><\/p>\n<p><a href=\"https:\/\/vimeo.com\/271958333\" rel=\"cc:attributionURL\">Lymph nodes\/Is it a Cold or the Flu\u00a0<\/a> by <a href=\"https:\/\/vimeo.com\/leehealth\">Lee Health<\/a> on Vimeo is used under <a href=\"https:\/\/vimeo.com\/terms#licenses\">Vimeo's Terms of Service<\/a> (https:\/\/vimeo.com\/terms#licenses).<\/p>\n<p><strong>Figure 17.1.2<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/ymo_yC_N_2o\" rel=\"cc:attributionURL\">mitchell-luo-ymo_yC_N_2o-unsplash<\/a> [photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@mitchel3uo\">Mitchell Luo<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 17.1.3<\/strong><\/p>\n<p><a href=\"https:\/\/flic.kr\/p\/qMacvT\" rel=\"cc:attributionURL\">Lymph node biopsy<\/a> by <a class=\"owner-name truncate\" title=\"Go to US Army Africa's photostream\" href=\"https:\/\/www.flickr.com\/photos\/usarmyafrica\/\" data-track=\"attributionNameClick\">US Army Africa<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\" rel=\"license\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Hodgkin's lymphoma [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/hodgkins-lymphoma\/symptoms-causes\/syc-20352646<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Non-Hodgkin's lymphoma [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/non-hodgkins-lymphoma\/symptoms-causes\/syc-20375680<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3164\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3164\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4803\" aria-describedby=\"caption-attachment-4803\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4803\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Lymph-nodes-1.png\" alt=\"17.1.1 Checking Lymph Nodes\" width=\"400\" height=\"380\"><figcaption id=\"caption-attachment-4803\" class=\"wp-caption-text\"><em>Figure 17.1.1 Health practitioners will often check your lymph nodes for unusual lumps.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Case Study: Defending Your Defenses<\/h1>\n<\/div>\n<figure id=\"attachment_4807\" aria-describedby=\"caption-attachment-4807\" style=\"width: 291px\" class=\"wp-caption alignright\"><img class=\" wp-image-4807\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/mitchell-luo-ymo_yC_N_2o-unsplash-scaled-2.jpg\" alt=\"17.1.2 Hakeem\" width=\"291\" height=\"437\"><figcaption id=\"caption-attachment-4807\" class=\"wp-caption-text\"><em>Figure 17.1.2 Hakeem is concerned about his health - he has been unusually tired, has been losing weight and most recently, found an unexpected lump on the side of his neck.<\/em><\/figcaption><\/figure>\n<p>Twenty-six-year-old Hakeem wasn\u2019t feeling well. He was more tired than usual, dragging through his workdays despite going to bed earlier, and napping on the weekends. He didn\u2019t have much of an appetite, and had started losing weight. When he pressed on the side of his neck, like the doctor is doing in Figure 17.1.1, he noticed an unusual lump.<\/p>\n<p>Hakeem went to his doctor, who performed a physical exam and determined that the lump was a swollen lymph node. Lymph nodes are part of the immune system, and they will often become enlarged when the body is fighting off an infection. Dr. Hayes thinks that the swollen lymph node and fatigue could be signs of a viral or bacterial infection, although he is concerned about Hakeem\u2019s lack of appetite and weight loss. All of those symptoms combined can indicate a type of cancer called lymphoma. An infection, however, is a more likely cause, particularly in a young person like Hakeem. Dr. Hayes prescribes an antibiotic in case Hakeem has a bacterial infection, and advises him to return in a few weeks if his lymph node does not shrink, or if he is not feeling better.<\/p>\n<p>Hakeem returns a few weeks later. He is not feeling better and his lymph node is still enlarged. Dr. Hayes is concerned, and orders a biopsy of the enlarged lymph node. A lymph node biopsy for suspected lymphoma often involves the surgical removal of all or part of a lymph node. This helps to determine whether the tissue contains cancerous cells.<\/p>\n<figure id=\"attachment_4808\" aria-describedby=\"caption-attachment-4808\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4808\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lymph-node-biopsy-by-US-Army-in-Africa-on-Flickr-1.jpg\" alt=\"17.1.3 Lymph Node Biopsy\" width=\"400\" height=\"314\"><figcaption id=\"caption-attachment-4808\" class=\"wp-caption-text\"><em>Figure 17.1.3 Surgeons performing a lymph node biopsy.<\/em><\/figcaption><\/figure>\n<p>The initial results of the biopsy indicate that Hakeem does have lymphoma. Although lymphoma is more common in older people, young adults and even children can get this disease. There are many types of lymphoma, with the two main types being <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/hodgkins-lymphoma\/symptoms-causes\/syc-20352646\">Hodgkin's lymphoma<\/a> and <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/non-hodgkins-lymphoma\/symptoms-causes\/syc-20375680\">non-Hodgkin's lymphoma<\/a>. Non-Hodgkin lymphoma (NHL), in turn, has many subtypes. The subtype depends on several factors, including which cell types are affected. Some subtypes of NHL, for example, affect immune system cells called B cells, while others affect different immune system cells called T cells.<\/p>\n<p>Dr. Hayes explains to Hakeem that it is important to determine which type of lymphoma he has, in order to choose the best course of treatment. Hakeem\u2019s biopsied tissue will be further examined and tested to see which cell types are affected, as well as which specific cell-surface proteins \u2014 called antigens \u2014 are present. This should help identify his specific type of lymphoma.<\/p>\n<p>As you read this chapter, you will learn about the functions of the immune system, and the specific roles that its cells and organs \u2014 such as B and T cells and lymph nodes \u2014 play in defending the body. At the end of this chapter, you will learn what type of lymphoma Hakeem has and what some of his treatment options are, including treatments that make use of the biochemistry of the immune system to fight cancer with the immune system itself.<\/p>\n<div>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter Overview: Immune System<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In this chapter, you will learn about the immune system \u2014 the system that defends the body against infections and other causes of disease, such as cancerous cells. Specifically, you will learn about:<\/p>\n<ul>\n<li>How the immune system identifies normal cells of the body as \u201cself\u201d and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_271\">pathogens<\/a> and damaged cells as \u201cnon-self.\u201d<\/li>\n<li>The two major subsystems of the general immune system: the innate immune system \u2014 which provides a quick, but non-specific response \u2014 and the adaptive immune system, which is slower, but provides a specific response that often results in long-lasting immunity.<\/li>\n<li>The specialized immune system that protects the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_2986\">brain<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3010\">spinal cord<\/a>, called the neuroimmune system.<\/li>\n<li>The organs, cells, and responses of the innate immune system, which includes physical barriers (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_3521\">skin<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_4571\">mucus<\/a>), chemical and biological barriers, inflammation, activation of the complement system of molecules, and non-specific cellular responses (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_1680\">phagocytosis<\/a>).<\/li>\n<li>The lymphatic system \u2014 which includes white blood cells called lymphocytes, lymphatic vessels (which transport a fluid called lymph), and organs (such as the spleen, tonsils, and lymph nodes) \u2014 and its important role in the adaptive immune system.<\/li>\n<li>Specific cells of the immune system and their functions, including B cells, T cells, plasma cells, and natural killer cells.<\/li>\n<li>How the adaptive immune system can generate specific and often long-lasting immunity against pathogens through the production of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4794_390\">antibodies<\/a>.<\/li>\n<li>How vaccines work to generate immunity.<\/li>\n<li>How cells in the immune system detect and kill cancerous cells.<\/li>\n<li>Some strategies that pathogens employ to evade the immune system.<\/li>\n<li>Disorders of the immune system, including allergies, autoimmune diseases (such as diabetes and multiple sclerosis), and immunodeficiency resulting from conditions such as HIV infection.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox shaded\">\n<p>As you read the chapter, think about the following questions:<\/p>\n<ol>\n<li>What are the functions of lymph nodes?<\/li>\n<li>What are B and T cells? How do they relate to lymph nodes?<\/li>\n<li>What are cell-surface antigens? How do they relate to the immune system and to cancer?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 17.1.1<\/strong><\/p>\n<p><a href=\"https:\/\/vimeo.com\/271958333\" rel=\"cc:attributionURL\">Lymph nodes\/Is it a Cold or the Flu\u00a0<\/a> by <a href=\"https:\/\/vimeo.com\/leehealth\">Lee Health<\/a> on Vimeo is used under <a href=\"https:\/\/vimeo.com\/terms#licenses\">Vimeo's Terms of Service<\/a> (https:\/\/vimeo.com\/terms#licenses).<\/p>\n<p><strong>Figure 17.1.2<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/ymo_yC_N_2o\" rel=\"cc:attributionURL\">mitchell-luo-ymo_yC_N_2o-unsplash<\/a> [photo] by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@mitchel3uo\">Mitchell Luo<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 17.1.3<\/strong><\/p>\n<p><a href=\"https:\/\/flic.kr\/p\/qMacvT\" rel=\"cc:attributionURL\">Lymph node biopsy<\/a> by <a class=\"owner-name truncate\" title=\"Go to US Army Africa's photostream\" href=\"https:\/\/www.flickr.com\/photos\/usarmyafrica\/\" data-track=\"attributionNameClick\">US Army Africa<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\" rel=\"license\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Hodgkin's lymphoma [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/hodgkins-lymphoma\/symptoms-causes\/syc-20352646<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Non-Hodgkin's lymphoma [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/non-hodgkins-lymphoma\/symptoms-causes\/syc-20375680<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4794_3165\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4794_3165\"><div tabindex=\"-1\"><p>Image shows a Scanning electron micrograph of a parasite.  It looks quite scary, with a creepy sucker-type thing on its neck<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"author":32,"menu_order":7,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":"cc-by-nc"},"chapter-type":[48],"contributor":[],"license":[55],"class_list":["post-4794","chapter","type-chapter","status-publish","hentry","chapter-type-numberless","license-cc-by-nc"],"part":4740,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/users\/32"}],"version-history":[{"count":4,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4794\/revisions"}],"predecessor-version":[{"id":6440,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4794\/revisions\/6440"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/parts\/4740"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4794\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/media?parent=4794"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapter-type?post=4794"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/contributor?post=4794"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/license?post=4794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}