{"id":4720,"date":"2020-04-01T17:24:17","date_gmt":"2020-04-01T17:24:17","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/9-4-human-organs-and-organ-systems-3\/"},"modified":"2023-11-30T18:48:48","modified_gmt":"2023-11-30T18:48:48","slug":"9-4-human-organs-and-organ-systems-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/9-4-human-organs-and-organ-systems-3\/","title":{"raw":"7.5 Human Organs and Organ Systems","rendered":"7.5 Human Organs and Organ Systems"},"content":{"raw":"<p id=\"x-ck12-ZWM5YzFkNDMyNzk3YjI3ODZmMjg1YTI2Mjk0YzM1Y2I.-7rf\"><\/p>\r\n\r\n\r\n[caption id=\"attachment_2903\" align=\"aligncenter\" width=\"300\"]<img class=\"wp-image-2903\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2020\/05\/I-heart-you-2.png\" alt=\"\" width=\"300\" height=\"166\" \/> <em>Figure 7.5.1\u00a0 I \"Heart\" You. <\/em>[\/caption]\r\n<h1>I \"Heart\" You<\/h1>\r\nYou've probably heard one song or another about the heart. Heartache, heartbreak... it's all related to love. But did you ever wonder <em>why<\/em>\u00a0we associate love with the\u00a0heart?\r\n<p id=\"x-ck12-ODdhYzUyYzJmNjBiYmJiZTI0YWQ1OTdiYzc1NDc1ZTE.-jru\">The\u00a0heart\u00a0was once thought to be the center of all thought processes, as well as the site of all emotions. This notion may have stemmed from very early anatomical dissections that found many nerves traced to the region of the heart. The fact that the heart may start racing when one is excited or otherwise emotionally aroused may have contributed to this idea, as well. In\u00a0reality, the heart is\u00a0<em>not<\/em> the organ that controls thoughts or emotions. The organ that controls those functions, in actuality, is the brain. In this section, you\u2019ll be introduced to the heart, brain, and other major organs of the human body.<\/p>\r\n\r\n<h1>Human Organs<\/h1>\r\n<p id=\"x-ck12-OGQwOTMzYmQ0ZWJlYTBiOTBjYmI4Yzg1YzFkNWU0MDA.-jsp\">An [pb_glossary id=\"2803\"]organ[\/pb_glossary] is a collection of [pb_glossary id=\"2801\"]tissues[\/pb_glossary] joined in a structural unit to serve a common function. Organs exist in most multicellular organisms, including humans, other\u00a0animals, and plants. In single-celled organisms (such as [pb_glossary id=\"2588\"]bacteria[\/pb_glossary]), the functional equivalent of an organ is an organelle.<\/p>\r\n\r\n<h2>Tissues in Organs<\/h2>\r\n<p id=\"x-ck12-NTRiNmJkZTc3YTZhMjI3NDhkYmYwN2Y2MjUwZWFkNGE.-rph\">Although organs consist of multiple tissue types, many organs are composed of a main tissue that is associated with the organ\u2019s major function, along with other tissues that play supporting roles. The main tissue may be unique to that specific organ. For example, the main tissue of the heart is cardiac muscle, which performs the heart\u2019s major function of pumping\u00a0blood\u00a0and is found only in the heart. The heart also includes nervous and connective tissues that are required for it to perform its major function. For example, nervous tissues control the beating of the heart, and connective tissues make up heart valves that keep blood flowing in just one direction through the heart.<\/p>\r\n\r\n<h2>Vital Organs<\/h2>\r\n<p id=\"x-ck12-MmUxMWJiMDYyNzc2ZTUyYmJiZDdmMzE5MzkwYjViMWQ.-y4l\">The\u00a0human body\u00a0contains five organs that are considered vital for survival: the heart, brain,\u00a0kidneys, liver, and lungs. The locations of these five organs \u2014 and several other internal organs \u2014 are shown in the figure below. If any of the five vital organs stops functioning and medical intervention is not readily available,\u00a0the organism's death will be\u00a0imminent.<\/p>\r\n\r\n<ol id=\"x-ck12-YTgzMDVhNTFjMWYxZWM3YjA5YWIwNzdlMzZlNDljOGY.-j8d\">\r\n \t<li>The\u00a0<strong>heart<\/strong>\u00a0is located in the center of the chest, and its function is to keep\u00a0blood\u00a0flowing through the body. Blood carries substances to the\u00a0cells\u00a0they need. It also carries wastes away from cells.<\/li>\r\n \t<li>The\u00a0<strong>brain<\/strong>\u00a0is located in the head and functions as the body\u2019s control center. It is the seat of all thoughts, memories, perceptions, and feelings.<\/li>\r\n \t<li>The two\u00a0<strong>kidneys<\/strong>\u00a0are located in the back of the abdomen on either side of the body. Their function is to filter\u00a0blood\u00a0and form urine, which is excreted from the body.<\/li>\r\n \t<li>The\u00a0<strong>liver<\/strong>\u00a0is located on the right side of the abdomen. Its functions\u00a0include filtering blood, secreting bile that is needed for digestion, and producing\u00a0proteins\u00a0necessary for blood clotting.<\/li>\r\n \t<li>The two\u00a0<strong>lungs<\/strong>\u00a0are located on either side of the upper chest. Their main function is exchanging oxygen and carbon dioxide with the blood.<\/li>\r\n<\/ol>\r\n[caption id=\"\" align=\"aligncenter\" width=\"400\"]<img src=\"https:\/\/dr282zn36sxxg.cloudfront.net\/datastreams\/f-d%3A4a411848a97e75d7b3663f6b0e4a7c5d4734e65f9ded290e0d908451%2BIMAGE_THUMB_POSTCARD_TINY%2BIMAGE_THUMB_POSTCARD_TINY.1\" alt=\"\" width=\"400\" height=\"444\" data-flx-url=\"\/flx\/show\/THUMB_POSTCARD\/image\/user%3Ay2fyaw5hlmnhaw4uaw50zxjuqgnrmtiub3jn\/2393109-1497550606-14-40-512px-Man_shadow_anatomy.png\" \/> <em>Figure 7.5.2 Human anatomy\/ Internal organs.\u00a0<\/em>[\/caption]\r\n<p id=\"x-ck12-MWI4M2RjOGY5OGFhMGRmZDAzYThjYzIwM2RmNWZiNjI.-jmo\">Use this shadow diagram of human anatomy to locate the five organs described above: heart, brain,\u00a0kidneys, liver, and lungs. Do you know the functions of any of the other organs in the diagram?<\/p>\r\n\r\n<h1>Human Organ Systems<\/h1>\r\n<p id=\"x-ck12-MmIxYmM3YzJlYjcxNDQ5ZWQyMTI1MzI4NTk5NzlkY2Q.-eoz\">Functionally related organs often cooperate to form whole organ systems. The 12 diagrams in Figure 7.5.3 show 11 human organ systems, including separate diagrams for the male and female reproductive systems. Some of the organs and functions of the organ systems are identified. Each system is also described in more detail in the text that follows. Most of these human organ systems are also the subject of separate chapters in this book.<\/p>\r\n\r\n<div id=\"x-ck12-ODhjYjI3ZWJmYjk0N2M2MzNkMGM5YjUzMjc2ODExMzQ.-3pi\" class=\"x-ck12-img-postcard x-ck12-nofloat\">\r\n<p id=\"x-ck12-MmIyZDljNjI4YmRlZWQwYTZhZjc1YTMzYjBlZmQ4YzA.-axo\">[h5p id=\"531\"]<\/p>\r\n<em>Figure 7.5.3 Human Organ Systems. These diagrams represent 11 human organ systems and show some of their organs and functions. The male and female reproductive systems are shown separately because of their significant differences.<\/em>\r\n\r\n<\/div>\r\n<div id=\"x-ck12-YjRhMjBjM2I4MmQyYjk5MjFjOGRiMGJjZTM0OGI4NjI.-3tk\" class=\"x-ck12-img-postcard x-ck12-nofloat\">\r\n<p id=\"x-ck12-ODc1MjdhNjBhNzdkOGRkM2JiY2FjYWFjYTExMTFlMjc.-xqj\"><span style=\"font-size: 1.424em; font-weight: bold;\">Integumentary System<\/span><\/p>\r\n\r\n<\/div>\r\n<p id=\"x-ck12-MGQ0NWI5ODM4M2ZiZmZiYTg5YWY3NWNiMDI0YzAyMjY.-dni\">Organs of the [pb_glossary id=\"2905\"]integumentary system[\/pb_glossary] include the skin, hair, and nails. The skin is the largest organ in the body. It encloses and protects the body and is the site of many sensory receptors. The skin is the body\u2019s first defense against pathogens, and it also helps regulate body\u00a0temperature\u00a0and eliminate wastes in sweat.<\/p>\r\n\r\n<h2>Skeletal System<\/h2>\r\n<p id=\"x-ck12-ZGJlZTBiMDY5YjRmZTE5ODk0ZDY1ZmMwNjkzOWUyMWQ.-lf8\">The\u00a0[pb_glossary id=\"2906\"]skeletal system[\/pb_glossary]\u00a0consists of\u00a0bones,\u00a0joints, teeth. The bones of the skeletal system are connected by tendons, ligaments, and cartilage. Functions of the skeletal system include supporting the body and giving it shape. Along with the muscular system, the skeletal system enables the body to move. The bones of the skeletal system also protect internal organs, store calcium, and produce red and white blood\u00a0cells.<\/p>\r\n\r\n<h2>Muscular System<\/h2>\r\n<p id=\"x-ck12-OTg0MzA5NDIyM2IxNTg0NzRkOWM4ZTc2YTBhNDE0ZjA.-gvk\">The [pb_glossary id=\"2907\"]muscular system[\/pb_glossary] consists of three different types of\u00a0muscles, including\u00a0skeletal muscles, which are attached to\u00a0bones\u00a0by tendons and allow for voluntary movements of the body. Smooth muscle tissues control the involuntary movements of internal organs, such as the organs of the\u00a0digestive system, allowing food to move through the system. Smooth muscles in\u00a0blood vessels\u00a0allow vasoconstriction and vasodilation, thereby helping to regulate body\u00a0temperature. Cardiac muscle tissues control the involuntary beating of the heart, allowing it to pump blood through the blood vessels of the\u00a0cardiovascular system.<\/p>\r\n\r\n<h2>Nervous System<\/h2>\r\n<p id=\"x-ck12-ZjFkNTEyYWUyZDNhN2NlYWJiZmIzMDFlNzJjY2QwOGY.-9kq\">The\u00a0[pb_glossary id=\"2908\"]nervous system\u00a0[\/pb_glossary]includes the brain and spinal cord \u2014 which make up the\u00a0central nervous system\u00a0\u2014 and nerves that run throughout the rest of the body, making up the\u00a0peripheral nervous system. The nervous system controls both voluntary and involuntary responses of the human organism, and also detects and processes sensory information.<\/p>\r\n\r\n<h2>Endocrine System<\/h2>\r\n<p id=\"x-ck12-NTExZjhjMzcwOTc2ZjY5NDUzMWI2YWY3M2MxN2ZjMDE.-xmo\">The\u00a0[pb_glossary id=\"5985\"]endocrine system[\/pb_glossary]\u00a0is made up of glands that secrete hormones into the blood, which then carries hormones throughout the body. Endocrine hormones are chemical messengers that control many body functions, including metabolism, growth, and sexual\u00a0development. The master gland of the endocrine system is the pituitary gland, which produces hormones that control other\u00a0endocrine glands. Some of the other endocrine glands include the pancreas, thyroid gland, and adrenal glands.<\/p>\r\n\r\n<h2>Cardiovascular System<\/h2>\r\n<p id=\"x-ck12-NWE0ZWU4Y2E3NGVmYTUwMDY5YmM0YzZkNDRhZWE4YTU.-roe\">The\u00a0[pb_glossary id=\"5927\"]cardiovascular system[\/pb_glossary]\u00a0(also called circulatory system) includes the heart, blood, and three types of\u00a0blood vessels: arteries, veins, and capillaries. The heart pumps blood, which travels through the blood vessels. The main function of the cardiovascular system is transport. Oxygen from the lungs and nutrients from the\u00a0digestive system\u00a0are transported to\u00a0cells\u00a0throughout the body. Carbon dioxide and other waste materials are picked up from the cells and transported to organs (such as the lungs and kidneys) for elimination from the body. The cardiovascular system also equalizes body\u00a0temperature\u00a0and transports endocrine hormones to cells in the body where they are needed.<\/p>\r\n\r\n<h2>Lymphatic System<\/h2>\r\n<p id=\"x-ck12-MGZhNWNhMzliNmFmNDRjZTgwMjFhYzI0YmUyYjJmODQ.-osh\">The[pb_glossary id=\"2911\"]\u00a0lymphatic system[\/pb_glossary]\u00a0is sometimes considered part of the immune system. It consists of a network of lymph vessels and ducts that collect excess fluid (called lymph) from extracellular spaces in tissues and transport the fluid to the bloodstream. The lymphatic system also includes many small collections of tissue, (called lymph nodes) and an organ called the spleen, both of which remove pathogens and cellular debris from the lymph or blood. In addition, the thymus gland in the lymphatic system produces some types of white blood cells (lymphocytes) that fight infections.<\/p>\r\n\r\n<h2>Respiratory System<\/h2>\r\n<p id=\"x-ck12-NjYwOTI3OGM4Y2U5MzMxYjNjYmQyNzE0NDcwMzc3OGQ.-mfg\">Organs and other structures of the\u00a0[pb_glossary id=\"2912\"]respiratory system[\/pb_glossary]\u00a0include the nasal passages, lungs, and a long tube called the trachea, which carries air between the nasal passages and lungs. The main function of the respiratory system is to deliver oxygen to the blood and remove carbon dioxide from the body. Gases are exchanged between the lungs and blood across the walls of capillaries lining tiny air sacs (alveoli) in the lungs.<\/p>\r\n\r\n<h2>Digestive System<\/h2>\r\n<p id=\"x-ck12-OTI4Y2I0ODI0ZjA5MDFmOGRlYjRhNzM3ZjUwN2EzZjM.-w7s\">The [pb_glossary id=\"5969\"]digestive system[\/pb_glossary] consists of several main organs\u00a0\u2014\u00a0including the mouth, esophagus, stomach, and small and large intestines \u2014 that form a long tube called the gastrointestinal (GI) tract. Food moves through this tract, where it is digested. Its nutrients are then absorbed, and its waste products are excreted. The digestive system also includes accessory organs (such as the pancreas and liver) that produce\u00a0enzymes\u00a0and other substances needed for digestion, but through which food does not actually pass.<\/p>\r\n\r\n<h2>Urinary System<\/h2>\r\n<p id=\"x-ck12-NjBlNmU2ZGYzOGY2ZTJmOGM4NDdjNTNjMGZkY2Y5OTA.-nrd\">The\u00a0[pb_glossary id=\"2914\"]urinary system[\/pb_glossary]\u00a0is\u00a0part of the\u00a0[pb_glossary id=\"5999\"]excretory system[\/pb_glossary], which\u00a0removes\u00a0wastes from the body. The\u00a0urinary system\u00a0includes the pair of kidneys, which filter excess\u00a0water\u00a0and a waste product (called urea) from the blood and form urine. Two tubes called ureters carry the urine from the kidneys to the urinary bladder, which stores the urine until it is excreted from the body through another tube\u00a0called\u00a0the urethra. The kidneys also produce an\u00a0enzyme\u00a0called renin and a variety of hormones. These substances help regulate\u00a0blood pressure, the production of red blood cells, and the balance of calcium and phosphorus in the body.<\/p>\r\n\r\n<h2>Male and Female Reproductive Systems<\/h2>\r\n<p id=\"x-ck12-ZTA3MTE2ODdlM2U4MjVkYzEyNDk3ZGM4MDRjMDhmODA.-w2i\">The [pb_glossary id=\"2916\"]reproductive system[\/pb_glossary] is the only body system that differs substantially between males and females. Both male and female reproductive systems produce sex-specific sex hormones (testosterone in males, estrogen in females) and gametes (sperm\u00a0in males, eggs in females). However, the organs involved in these processes are different. The\u00a0male reproductive system\u00a0includes the epididymis, testes, and penis. The\u00a0female reproductive system\u00a0includes the uterus, ovaries, and mammary glands. The male and female systems also have different additional roles. For example, the male system has the role of delivering gametes to the female reproductive tract, whereas the female system has the roles of supporting an embryo and fetus until birth and also producing milk for the infant after birth.<\/p>\r\n\r\n<h1>Feature: Human Biology in the News<\/h1>\r\n<p id=\"x-ck12-ZDA0Zjk1Zjk0ZTYyMTI2MTYxMmU1Mjc4MDcyYmExODM.-6hl\">Organ transplantation has been performed by surgeons for more than six decades, and you\u2019ve no doubt heard of people receiving heart, lung, and kidney transplants. However, you may have never heard of a penis transplant. The first U.S. penis transplant was performed in May 2016 at Massachusetts General Hospital in Boston. The 15-hour procedure involved a team of more than 50 physicians, surgeons, and nurses. The patient was a 64-year-old man who had lost his penis to\u00a0cancer\u00a0in 2012. The surgical milestone involved grafting microscopic\u00a0blood vessels\u00a0and nerves of the donor organ to those of the recipient. As with most transplant patients, this patient will have to take immunosuppressing drugs for the rest of his life so his immune system will not reject the organ. The transplant team said that their success with this transplant \u201cholds promise for patients with devastating genitourinary injuries and disease.\u201d They also hope their experiences will be helpful for gender reassignment surgery.<\/p>\r\nSee the Johns Hopkins Medicine video below for a summary of how the penile and scrotum transplant procedure was carried out:\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=NwHxIhP7zTE\r\n<p style=\"text-align: center;\">World's First Total Penile and Scrotum Transplant | Johns Hopkins Medicine, 2018.<\/p>\r\n\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 style=\"margin-top: 2.14286em; margin-bottom: 1.42857em; line-height: 1.28571em; color: #333333;\"><span style=\"color: #ffffff;\">7.5\u00a0Summary<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul id=\"x-ck12-OWFhNDVjNmFiNDJmMzM5YWI1OWRjNWNiYWY5OWYxNWQ.-gne\">\r\n \t<li>An organ is a collection of tissues joined in a structural unit to serve a common function. Many organs are composed of a major tissue that performs the organ\u2019s main function, as well as other tissues that play supporting roles.<\/li>\r\n \t<li>The human body contains five organs that are considered vital for survival. They are the heart, brain, kidneys, liver, and lungs. If any of these five organs stops functioning, death of the organism is imminent without medical intervention.<\/li>\r\n \t<li>Functionally related organs often cooperate to form whole organ systems. There are 11 major organ systems in the human organism. They are the integumentary, skeletal, muscular, nervous, endocrine, cardiovascular, lymphatic, respiratory, digestive, urinary, and reproductive systems. Only the reproductive system varies significantly between males and females.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 style=\"margin-top: 2.14286em; margin-bottom: 1.42857em; line-height: 1.28571em; color: #333333;\"><span style=\"color: #ffffff;\">7.5 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div>\r\n<ol>\r\n \t<li id=\"x-ck12-N2IwOGZhZDBhMjA3NTZhMThlZTQ3Yjg2NWEwNTQ4OWI.-pj6\">What is the primary tissue in the heart, and what is its role?<\/li>\r\n \t<li id=\"x-ck12-MDAyOGM5ZDhjZWU5ZGU4N2I4NTZiZGE1YjRiODNjMjQ.-nwp\">What non-muscle tissues are found in the heart? What are their functions?<\/li>\r\n \t<li id=\"x-ck12-NTIxZGE0NDU2MmE1ZGQ0ZDMwZmJiNGQ4MjFmYjllMmQ.-js9\">Identify two vital organs in the human body. Identify their locations and functions.<\/li>\r\n \t<li id=\"x-ck12-YWJiYzU3ZmJmNzU0ODlkNjA1ZTVlNDczYzg3Njg2MTI.-is1\">List three human organ systems. For each organ system, identify some of its organs and functions.<\/li>\r\n \t<li id=\"x-ck12-ODZiOTYyYTc1Y2ViYTJhZTdhNzRlOWQyNmJkMWYyYzk.-g9d\">Compare and contrast the male and female reproductive systems.<\/li>\r\n \t<li id=\"x-ck12-OTFiOTAzNDdkNmVmYTcwZmQxZjBiYjYyZmZhMWM1NGE.-xt4\">For each of the following pairs of organ systems, describe one way in which they work together and\/or overlap:\r\n<ol type=\"a\">\r\n \t<li id=\"x-ck12-OGZmZGRkM2E1OGVlNmY5NmIxMmM4ODcxYjE1NTJlNDM.-rns\">skeletal system and muscular system<\/li>\r\n \t<li id=\"x-ck12-ZWE0YjljZmE3MzE1MGZkYzhiNDViZDYwZjM4MTM2MzU.-l91\">muscular system and digestive system<\/li>\r\n \t<li id=\"x-ck12-NmFmOWRiYTlmNjQ4ZGI0ZjRhNTYxZDY4NzMxNjBmMGI.-yhi\">endocrine system and reproductive system<\/li>\r\n \t<li id=\"x-ck12-NDUxYjcwNTE5Y2I3NWUxM2ZmZTY3MjUwOTkyM2FlYmE.-wjo\">cardiovascular system and urinary system<\/li>\r\n<\/ol>\r\n<\/li>\r\n \t<li id=\"x-ck12-NjA5MDdmMmZlMDMzMDQ2OWI1YWE3OTQ2ODBkOTEzY2E.-mu6\">What is the largest organ of the human body?<\/li>\r\n \t<li id=\"x-ck12-YjQ4M2MxZDU3NjI3YjQzZWI5NTQxOWU3N2UxNDQ0ODk.-j2g\">What are three organ systems involved in regulating human body temperature?<\/li>\r\n \t<li>[h5p id=\"543\"]<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div id=\"x-ck12-r78\" class=\"x-ck12-video-object\">\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 style=\"margin-top: 2.14286em; margin-bottom: 1.42857em; line-height: 1.28571em; color: #333333;\"><span style=\"color: #ffffff;\">7.5 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=Ae4MadKPJC0\r\n<p style=\"text-align: center;\">Human Body 101 | National Geographic, 2017.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=gEUu-A2wfSE\r\n<p style=\"text-align: center;\">Human Body Systems Functions Overview: The 11 Champions (Updated),\r\nAmoeba Sisters, 2016.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n<span style=\"font-size: 1.424em; font-weight: bold;\">Attributions<\/span>\r\n\r\n<\/div>\r\n<strong>Figure 7.5.1<\/strong>\r\n\r\n<a href=\"https:\/\/pixabay.com\/vectors\/love-i-love-you-heart-red-yellow-317639\/\">I \"heart\" you<\/a> by <a class=\"hover_opacity\" href=\"https:\/\/pixabay.com\/users\/Mocho-156870\/\">Mocho<\/a>\u00a0on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).\r\n\r\n<strong>Figure 7.5.2<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Internal_organs.svg\">Internal organs<\/a> by <a class=\"extiw\" title=\"en:User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain <\/a>(https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 7.5.3<\/strong>\r\n<ul>\r\n \t<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Organ_Systems_I.jpg\">Organ Systems I<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-2-structural-organization-of-the-human-body\">OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/li>\r\n \t<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Organ_Systems_II.jpg\">Organ Systems II<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-2-structural-organization-of-the-human-body\">OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/li>\r\n<\/ul>\r\n<h2>References<\/h2>\r\n<p class=\"hanging-indent\">Amoeba Sisters. (2016, April 24). Human body systems functions overview: The 11 champions. YouTube. https:\/\/www.youtube.com\/watch?v=gEUu-A2wfSE&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, April 25). Figure\u00a0<\/span><span class=\"os-number\">1.4<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"7375\" class=\"os-title\" data-type=\"title\">Organ systems of the human <span class=\"search-highlight first text last\" data-timestamp=\"1595360261558\" data-highlight-id=\"440dec11-99f1-4524-9fb9-eff301bd492c\" data-highlighted=\"true\">body [digital image]. In <em>Anatomy and Physiology<\/em> (Section 1.2). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-2-structural-organization-of-the-human-body#fig-ch01_02_03<\/span><\/span><\/p>\r\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, April 25). Figure <\/span><span class=\"os-number\">1.5<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"53825\" class=\"os-title\" data-type=\"title\">Organ systems of the human <span class=\"search-highlight first text last\" data-timestamp=\"1595360261572\" data-highlight-id=\"ec405e56-fd1b-4cf6-888e-182230bcddc7\" data-highlighted=\"true\">body<\/span>\u00a0(continued)<\/span><span class=\"os-divider\"> <span id=\"7375\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight first text last\" data-timestamp=\"1595360261558\" data-highlight-id=\"440dec11-99f1-4524-9fb9-eff301bd492c\" data-highlighted=\"true\">[digital image]. In <em>Anatomy and Physiology<\/em> (Section 1.2). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-2-structural-organization-of-the-human-body#fig-ch01_02_03<\/span><\/span><\/span><\/p>\r\n<p class=\"hanging-indent\">Johns Hopkins Medicine. (2018, ). World's first total penile and scrotum transplant | Johns Hopkins Medicine. YouTube. https:\/\/www.youtube.com\/watch?v=NwHxIhP7zTE&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">National Geographic. (2017, December 1). Human body 101 | National Geographic. YouTube. https:\/\/www.youtube.com\/watch?v=Ae4MadKPJC0&amp;feature=youtu.be<\/p>\r\n&nbsp;","rendered":"<p id=\"x-ck12-ZWM5YzFkNDMyNzk3YjI3ODZmMjg1YTI2Mjk0YzM1Y2I.-7rf\">\n<figure id=\"attachment_2903\" aria-describedby=\"caption-attachment-2903\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2903\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2020\/05\/I-heart-you-2.png\" alt=\"\" width=\"300\" height=\"166\" \/><figcaption id=\"caption-attachment-2903\" class=\"wp-caption-text\"><em>Figure 7.5.1\u00a0 I &#8220;Heart&#8221; You. <\/em><\/figcaption><\/figure>\n<h1>I &#8220;Heart&#8221; You<\/h1>\n<p>You&#8217;ve probably heard one song or another about the heart. Heartache, heartbreak&#8230; it&#8217;s all related to love. But did you ever wonder <em>why<\/em>\u00a0we associate love with the\u00a0heart?<\/p>\n<p id=\"x-ck12-ODdhYzUyYzJmNjBiYmJiZTI0YWQ1OTdiYzc1NDc1ZTE.-jru\">The\u00a0heart\u00a0was once thought to be the center of all thought processes, as well as the site of all emotions. This notion may have stemmed from very early anatomical dissections that found many nerves traced to the region of the heart. The fact that the heart may start racing when one is excited or otherwise emotionally aroused may have contributed to this idea, as well. In\u00a0reality, the heart is\u00a0<em>not<\/em> the organ that controls thoughts or emotions. The organ that controls those functions, in actuality, is the brain. In this section, you\u2019ll be introduced to the heart, brain, and other major organs of the human body.<\/p>\n<h1>Human Organs<\/h1>\n<p id=\"x-ck12-OGQwOTMzYmQ0ZWJlYTBiOTBjYmI4Yzg1YzFkNWU0MDA.-jsp\">An <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2803\">organ<\/a> is a collection of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2801\">tissues<\/a> joined in a structural unit to serve a common function. Organs exist in most multicellular organisms, including humans, other\u00a0animals, and plants. In single-celled organisms (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2588\">bacteria<\/a>), the functional equivalent of an organ is an organelle.<\/p>\n<h2>Tissues in Organs<\/h2>\n<p id=\"x-ck12-NTRiNmJkZTc3YTZhMjI3NDhkYmYwN2Y2MjUwZWFkNGE.-rph\">Although organs consist of multiple tissue types, many organs are composed of a main tissue that is associated with the organ\u2019s major function, along with other tissues that play supporting roles. The main tissue may be unique to that specific organ. For example, the main tissue of the heart is cardiac muscle, which performs the heart\u2019s major function of pumping\u00a0blood\u00a0and is found only in the heart. The heart also includes nervous and connective tissues that are required for it to perform its major function. For example, nervous tissues control the beating of the heart, and connective tissues make up heart valves that keep blood flowing in just one direction through the heart.<\/p>\n<h2>Vital Organs<\/h2>\n<p id=\"x-ck12-MmUxMWJiMDYyNzc2ZTUyYmJiZDdmMzE5MzkwYjViMWQ.-y4l\">The\u00a0human body\u00a0contains five organs that are considered vital for survival: the heart, brain,\u00a0kidneys, liver, and lungs. The locations of these five organs \u2014 and several other internal organs \u2014 are shown in the figure below. If any of the five vital organs stops functioning and medical intervention is not readily available,\u00a0the organism&#8217;s death will be\u00a0imminent.<\/p>\n<ol id=\"x-ck12-YTgzMDVhNTFjMWYxZWM3YjA5YWIwNzdlMzZlNDljOGY.-j8d\">\n<li>The\u00a0<strong>heart<\/strong>\u00a0is located in the center of the chest, and its function is to keep\u00a0blood\u00a0flowing through the body. Blood carries substances to the\u00a0cells\u00a0they need. It also carries wastes away from cells.<\/li>\n<li>The\u00a0<strong>brain<\/strong>\u00a0is located in the head and functions as the body\u2019s control center. It is the seat of all thoughts, memories, perceptions, and feelings.<\/li>\n<li>The two\u00a0<strong>kidneys<\/strong>\u00a0are located in the back of the abdomen on either side of the body. Their function is to filter\u00a0blood\u00a0and form urine, which is excreted from the body.<\/li>\n<li>The\u00a0<strong>liver<\/strong>\u00a0is located on the right side of the abdomen. Its functions\u00a0include filtering blood, secreting bile that is needed for digestion, and producing\u00a0proteins\u00a0necessary for blood clotting.<\/li>\n<li>The two\u00a0<strong>lungs<\/strong>\u00a0are located on either side of the upper chest. Their main function is exchanging oxygen and carbon dioxide with the blood.<\/li>\n<\/ol>\n<figure style=\"width: 400px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dr282zn36sxxg.cloudfront.net\/datastreams\/f-d%3A4a411848a97e75d7b3663f6b0e4a7c5d4734e65f9ded290e0d908451%2BIMAGE_THUMB_POSTCARD_TINY%2BIMAGE_THUMB_POSTCARD_TINY.1\" alt=\"\" width=\"400\" height=\"444\" data-flx-url=\"\/flx\/show\/THUMB_POSTCARD\/image\/user%3Ay2fyaw5hlmnhaw4uaw50zxjuqgnrmtiub3jn\/2393109-1497550606-14-40-512px-Man_shadow_anatomy.png\" \/><figcaption class=\"wp-caption-text\"><em>Figure 7.5.2 Human anatomy\/ Internal organs.\u00a0<\/em><\/figcaption><\/figure>\n<p id=\"x-ck12-MWI4M2RjOGY5OGFhMGRmZDAzYThjYzIwM2RmNWZiNjI.-jmo\">Use this shadow diagram of human anatomy to locate the five organs described above: heart, brain,\u00a0kidneys, liver, and lungs. Do you know the functions of any of the other organs in the diagram?<\/p>\n<h1>Human Organ Systems<\/h1>\n<p id=\"x-ck12-MmIxYmM3YzJlYjcxNDQ5ZWQyMTI1MzI4NTk5NzlkY2Q.-eoz\">Functionally related organs often cooperate to form whole organ systems. The 12 diagrams in Figure 7.5.3 show 11 human organ systems, including separate diagrams for the male and female reproductive systems. Some of the organs and functions of the organ systems are identified. Each system is also described in more detail in the text that follows. Most of these human organ systems are also the subject of separate chapters in this book.<\/p>\n<div id=\"x-ck12-ODhjYjI3ZWJmYjk0N2M2MzNkMGM5YjUzMjc2ODExMzQ.-3pi\" class=\"x-ck12-img-postcard x-ck12-nofloat\">\n<p id=\"x-ck12-MmIyZDljNjI4YmRlZWQwYTZhZjc1YTMzYjBlZmQ4YzA.-axo\">\n<div id=\"h5p-531\">\n<div class=\"h5p-content\" data-content-id=\"531\"><\/div>\n<\/div>\n<p><em>Figure 7.5.3 Human Organ Systems. These diagrams represent 11 human organ systems and show some of their organs and functions. The male and female reproductive systems are shown separately because of their significant differences.<\/em><\/p>\n<\/div>\n<div id=\"x-ck12-YjRhMjBjM2I4MmQyYjk5MjFjOGRiMGJjZTM0OGI4NjI.-3tk\" class=\"x-ck12-img-postcard x-ck12-nofloat\">\n<p id=\"x-ck12-ODc1MjdhNjBhNzdkOGRkM2JiY2FjYWFjYTExMTFlMjc.-xqj\"><span style=\"font-size: 1.424em; font-weight: bold;\">Integumentary System<\/span><\/p>\n<\/div>\n<p id=\"x-ck12-MGQ0NWI5ODM4M2ZiZmZiYTg5YWY3NWNiMDI0YzAyMjY.-dni\">Organs of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2905\">integumentary system<\/a> include the skin, hair, and nails. The skin is the largest organ in the body. It encloses and protects the body and is the site of many sensory receptors. The skin is the body\u2019s first defense against pathogens, and it also helps regulate body\u00a0temperature\u00a0and eliminate wastes in sweat.<\/p>\n<h2>Skeletal System<\/h2>\n<p id=\"x-ck12-ZGJlZTBiMDY5YjRmZTE5ODk0ZDY1ZmMwNjkzOWUyMWQ.-lf8\">The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2906\">skeletal system<\/a>\u00a0consists of\u00a0bones,\u00a0joints, teeth. The bones of the skeletal system are connected by tendons, ligaments, and cartilage. Functions of the skeletal system include supporting the body and giving it shape. Along with the muscular system, the skeletal system enables the body to move. The bones of the skeletal system also protect internal organs, store calcium, and produce red and white blood\u00a0cells.<\/p>\n<h2>Muscular System<\/h2>\n<p id=\"x-ck12-OTg0MzA5NDIyM2IxNTg0NzRkOWM4ZTc2YTBhNDE0ZjA.-gvk\">The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2907\">muscular system<\/a> consists of three different types of\u00a0muscles, including\u00a0skeletal muscles, which are attached to\u00a0bones\u00a0by tendons and allow for voluntary movements of the body. Smooth muscle tissues control the involuntary movements of internal organs, such as the organs of the\u00a0digestive system, allowing food to move through the system. Smooth muscles in\u00a0blood vessels\u00a0allow vasoconstriction and vasodilation, thereby helping to regulate body\u00a0temperature. Cardiac muscle tissues control the involuntary beating of the heart, allowing it to pump blood through the blood vessels of the\u00a0cardiovascular system.<\/p>\n<h2>Nervous System<\/h2>\n<p id=\"x-ck12-ZjFkNTEyYWUyZDNhN2NlYWJiZmIzMDFlNzJjY2QwOGY.-9kq\">The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2908\">nervous system\u00a0<\/a>includes the brain and spinal cord \u2014 which make up the\u00a0central nervous system\u00a0\u2014 and nerves that run throughout the rest of the body, making up the\u00a0peripheral nervous system. The nervous system controls both voluntary and involuntary responses of the human organism, and also detects and processes sensory information.<\/p>\n<h2>Endocrine System<\/h2>\n<p id=\"x-ck12-NTExZjhjMzcwOTc2ZjY5NDUzMWI2YWY3M2MxN2ZjMDE.-xmo\">The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_5985\">endocrine system<\/a>\u00a0is made up of glands that secrete hormones into the blood, which then carries hormones throughout the body. Endocrine hormones are chemical messengers that control many body functions, including metabolism, growth, and sexual\u00a0development. The master gland of the endocrine system is the pituitary gland, which produces hormones that control other\u00a0endocrine glands. Some of the other endocrine glands include the pancreas, thyroid gland, and adrenal glands.<\/p>\n<h2>Cardiovascular System<\/h2>\n<p id=\"x-ck12-NWE0ZWU4Y2E3NGVmYTUwMDY5YmM0YzZkNDRhZWE4YTU.-roe\">The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_5927\">cardiovascular system<\/a>\u00a0(also called circulatory system) includes the heart, blood, and three types of\u00a0blood vessels: arteries, veins, and capillaries. The heart pumps blood, which travels through the blood vessels. The main function of the cardiovascular system is transport. Oxygen from the lungs and nutrients from the\u00a0digestive system\u00a0are transported to\u00a0cells\u00a0throughout the body. Carbon dioxide and other waste materials are picked up from the cells and transported to organs (such as the lungs and kidneys) for elimination from the body. The cardiovascular system also equalizes body\u00a0temperature\u00a0and transports endocrine hormones to cells in the body where they are needed.<\/p>\n<h2>Lymphatic System<\/h2>\n<p id=\"x-ck12-MGZhNWNhMzliNmFmNDRjZTgwMjFhYzI0YmUyYjJmODQ.-osh\">The<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2911\">\u00a0lymphatic system<\/a>\u00a0is sometimes considered part of the immune system. It consists of a network of lymph vessels and ducts that collect excess fluid (called lymph) from extracellular spaces in tissues and transport the fluid to the bloodstream. The lymphatic system also includes many small collections of tissue, (called lymph nodes) and an organ called the spleen, both of which remove pathogens and cellular debris from the lymph or blood. In addition, the thymus gland in the lymphatic system produces some types of white blood cells (lymphocytes) that fight infections.<\/p>\n<h2>Respiratory System<\/h2>\n<p id=\"x-ck12-NjYwOTI3OGM4Y2U5MzMxYjNjYmQyNzE0NDcwMzc3OGQ.-mfg\">Organs and other structures of the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2912\">respiratory system<\/a>\u00a0include the nasal passages, lungs, and a long tube called the trachea, which carries air between the nasal passages and lungs. The main function of the respiratory system is to deliver oxygen to the blood and remove carbon dioxide from the body. Gases are exchanged between the lungs and blood across the walls of capillaries lining tiny air sacs (alveoli) in the lungs.<\/p>\n<h2>Digestive System<\/h2>\n<p id=\"x-ck12-OTI4Y2I0ODI0ZjA5MDFmOGRlYjRhNzM3ZjUwN2EzZjM.-w7s\">The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_5969\">digestive system<\/a> consists of several main organs\u00a0\u2014\u00a0including the mouth, esophagus, stomach, and small and large intestines \u2014 that form a long tube called the gastrointestinal (GI) tract. Food moves through this tract, where it is digested. Its nutrients are then absorbed, and its waste products are excreted. The digestive system also includes accessory organs (such as the pancreas and liver) that produce\u00a0enzymes\u00a0and other substances needed for digestion, but through which food does not actually pass.<\/p>\n<h2>Urinary System<\/h2>\n<p id=\"x-ck12-NjBlNmU2ZGYzOGY2ZTJmOGM4NDdjNTNjMGZkY2Y5OTA.-nrd\">The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2914\">urinary system<\/a>\u00a0is\u00a0part of the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_5999\">excretory system<\/a>, which\u00a0removes\u00a0wastes from the body. The\u00a0urinary system\u00a0includes the pair of kidneys, which filter excess\u00a0water\u00a0and a waste product (called urea) from the blood and form urine. Two tubes called ureters carry the urine from the kidneys to the urinary bladder, which stores the urine until it is excreted from the body through another tube\u00a0called\u00a0the urethra. The kidneys also produce an\u00a0enzyme\u00a0called renin and a variety of hormones. These substances help regulate\u00a0blood pressure, the production of red blood cells, and the balance of calcium and phosphorus in the body.<\/p>\n<h2>Male and Female Reproductive Systems<\/h2>\n<p id=\"x-ck12-ZTA3MTE2ODdlM2U4MjVkYzEyNDk3ZGM4MDRjMDhmODA.-w2i\">The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2916\">reproductive system<\/a> is the only body system that differs substantially between males and females. Both male and female reproductive systems produce sex-specific sex hormones (testosterone in males, estrogen in females) and gametes (sperm\u00a0in males, eggs in females). However, the organs involved in these processes are different. The\u00a0male reproductive system\u00a0includes the epididymis, testes, and penis. The\u00a0female reproductive system\u00a0includes the uterus, ovaries, and mammary glands. The male and female systems also have different additional roles. For example, the male system has the role of delivering gametes to the female reproductive tract, whereas the female system has the roles of supporting an embryo and fetus until birth and also producing milk for the infant after birth.<\/p>\n<h1>Feature: Human Biology in the News<\/h1>\n<p id=\"x-ck12-ZDA0Zjk1Zjk0ZTYyMTI2MTYxMmU1Mjc4MDcyYmExODM.-6hl\">Organ transplantation has been performed by surgeons for more than six decades, and you\u2019ve no doubt heard of people receiving heart, lung, and kidney transplants. However, you may have never heard of a penis transplant. The first U.S. penis transplant was performed in May 2016 at Massachusetts General Hospital in Boston. The 15-hour procedure involved a team of more than 50 physicians, surgeons, and nurses. The patient was a 64-year-old man who had lost his penis to\u00a0cancer\u00a0in 2012. The surgical milestone involved grafting microscopic\u00a0blood vessels\u00a0and nerves of the donor organ to those of the recipient. As with most transplant patients, this patient will have to take immunosuppressing drugs for the rest of his life so his immune system will not reject the organ. The transplant team said that their success with this transplant \u201cholds promise for patients with devastating genitourinary injuries and disease.\u201d They also hope their experiences will be helpful for gender reassignment surgery.<\/p>\n<p>See the Johns Hopkins Medicine video below for a summary of how the penile and scrotum transplant procedure was carried out:<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"World&#39;s First Total Penile and Scrotum Transplant | Johns Hopkins Medicine\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/NwHxIhP7zTE?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">World&#8217;s First Total Penile and Scrotum Transplant | Johns Hopkins Medicine, 2018.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 style=\"margin-top: 2.14286em; margin-bottom: 1.42857em; line-height: 1.28571em; color: #333333;\"><span style=\"color: #ffffff;\">7.5\u00a0Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul id=\"x-ck12-OWFhNDVjNmFiNDJmMzM5YWI1OWRjNWNiYWY5OWYxNWQ.-gne\">\n<li>An organ is a collection of tissues joined in a structural unit to serve a common function. Many organs are composed of a major tissue that performs the organ\u2019s main function, as well as other tissues that play supporting roles.<\/li>\n<li>The human body contains five organs that are considered vital for survival. They are the heart, brain, kidneys, liver, and lungs. If any of these five organs stops functioning, death of the organism is imminent without medical intervention.<\/li>\n<li>Functionally related organs often cooperate to form whole organ systems. There are 11 major organ systems in the human organism. They are the integumentary, skeletal, muscular, nervous, endocrine, cardiovascular, lymphatic, respiratory, digestive, urinary, and reproductive systems. Only the reproductive system varies significantly between males and females.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 style=\"margin-top: 2.14286em; margin-bottom: 1.42857em; line-height: 1.28571em; color: #333333;\"><span style=\"color: #ffffff;\">7.5 Review Questions<\/span><\/h1>\n<\/header>\n<div>\n<ol>\n<li id=\"x-ck12-N2IwOGZhZDBhMjA3NTZhMThlZTQ3Yjg2NWEwNTQ4OWI.-pj6\">What is the primary tissue in the heart, and what is its role?<\/li>\n<li id=\"x-ck12-MDAyOGM5ZDhjZWU5ZGU4N2I4NTZiZGE1YjRiODNjMjQ.-nwp\">What non-muscle tissues are found in the heart? What are their functions?<\/li>\n<li id=\"x-ck12-NTIxZGE0NDU2MmE1ZGQ0ZDMwZmJiNGQ4MjFmYjllMmQ.-js9\">Identify two vital organs in the human body. Identify their locations and functions.<\/li>\n<li id=\"x-ck12-YWJiYzU3ZmJmNzU0ODlkNjA1ZTVlNDczYzg3Njg2MTI.-is1\">List three human organ systems. For each organ system, identify some of its organs and functions.<\/li>\n<li id=\"x-ck12-ODZiOTYyYTc1Y2ViYTJhZTdhNzRlOWQyNmJkMWYyYzk.-g9d\">Compare and contrast the male and female reproductive systems.<\/li>\n<li id=\"x-ck12-OTFiOTAzNDdkNmVmYTcwZmQxZjBiYjYyZmZhMWM1NGE.-xt4\">For each of the following pairs of organ systems, describe one way in which they work together and\/or overlap:\n<ol type=\"a\">\n<li id=\"x-ck12-OGZmZGRkM2E1OGVlNmY5NmIxMmM4ODcxYjE1NTJlNDM.-rns\">skeletal system and muscular system<\/li>\n<li id=\"x-ck12-ZWE0YjljZmE3MzE1MGZkYzhiNDViZDYwZjM4MTM2MzU.-l91\">muscular system and digestive system<\/li>\n<li id=\"x-ck12-NmFmOWRiYTlmNjQ4ZGI0ZjRhNTYxZDY4NzMxNjBmMGI.-yhi\">endocrine system and reproductive system<\/li>\n<li id=\"x-ck12-NDUxYjcwNTE5Y2I3NWUxM2ZmZTY3MjUwOTkyM2FlYmE.-wjo\">cardiovascular system and urinary system<\/li>\n<\/ol>\n<\/li>\n<li id=\"x-ck12-NjA5MDdmMmZlMDMzMDQ2OWI1YWE3OTQ2ODBkOTEzY2E.-mu6\">What is the largest organ of the human body?<\/li>\n<li id=\"x-ck12-YjQ4M2MxZDU3NjI3YjQzZWI5NTQxOWU3N2UxNDQ0ODk.-j2g\">What are three organ systems involved in regulating human body temperature?<\/li>\n<li>\n<div id=\"h5p-543\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-543\" class=\"h5p-iframe\" data-content-id=\"543\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"7.5 Review\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div id=\"x-ck12-r78\" class=\"x-ck12-video-object\">\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 style=\"margin-top: 2.14286em; margin-bottom: 1.42857em; line-height: 1.28571em; color: #333333;\"><span style=\"color: #ffffff;\">7.5 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"Human Body 101 | National Geographic\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/Ae4MadKPJC0?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Human Body 101 | National Geographic, 2017.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-3\" title=\"Human Body Systems Functions Overview: The 11 Champions (Older Video 2016)\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/gEUu-A2wfSE?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Human Body Systems Functions Overview: The 11 Champions (Updated),<br \/>\nAmoeba Sisters, 2016.<\/p>\n<\/div>\n<\/div>\n<p><span style=\"font-size: 1.424em; font-weight: bold;\">Attributions<\/span><\/p>\n<\/div>\n<p><strong>Figure 7.5.1<\/strong><\/p>\n<p><a href=\"https:\/\/pixabay.com\/vectors\/love-i-love-you-heart-red-yellow-317639\/\">I &#8220;heart&#8221; you<\/a> by <a class=\"hover_opacity\" href=\"https:\/\/pixabay.com\/users\/Mocho-156870\/\">Mocho<\/a>\u00a0on <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/p>\n<p><strong>Figure 7.5.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Internal_organs.svg\">Internal organs<\/a> by <a class=\"extiw\" title=\"en:User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain <\/a>(https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 7.5.3<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Organ_Systems_I.jpg\">Organ Systems I<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-2-structural-organization-of-the-human-body\">OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Organ_Systems_II.jpg\">Organ Systems II<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-2-structural-organization-of-the-human-body\">OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/li>\n<\/ul>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2016, April 24). Human body systems functions overview: The 11 champions. YouTube. https:\/\/www.youtube.com\/watch?v=gEUu-A2wfSE&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, April 25). Figure\u00a0<\/span><span class=\"os-number\">1.4<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"7375\" class=\"os-title\" data-type=\"title\">Organ systems of the human <span class=\"search-highlight first text last\" data-timestamp=\"1595360261558\" data-highlight-id=\"440dec11-99f1-4524-9fb9-eff301bd492c\" data-highlighted=\"true\">body [digital image]. In <em>Anatomy and Physiology<\/em> (Section 1.2). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-2-structural-organization-of-the-human-body#fig-ch01_02_03<\/span><\/span><\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, April 25). Figure <\/span><span class=\"os-number\">1.5<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"53825\" class=\"os-title\" data-type=\"title\">Organ systems of the human <span class=\"search-highlight first text last\" data-timestamp=\"1595360261572\" data-highlight-id=\"ec405e56-fd1b-4cf6-888e-182230bcddc7\" data-highlighted=\"true\">body<\/span>\u00a0(continued)<\/span><span class=\"os-divider\"> <span class=\"os-title\" data-type=\"title\"><span class=\"search-highlight first text last\" data-timestamp=\"1595360261558\" data-highlight-id=\"440dec11-99f1-4524-9fb9-eff301bd492c\" data-highlighted=\"true\">[digital image]. In <em>Anatomy and Physiology<\/em> (Section 1.2). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-2-structural-organization-of-the-human-body#fig-ch01_02_03<\/span><\/span><\/span><\/p>\n<p class=\"hanging-indent\">Johns Hopkins Medicine. (2018, ). World&#8217;s first total penile and scrotum transplant | Johns Hopkins Medicine. YouTube. https:\/\/www.youtube.com\/watch?v=NwHxIhP7zTE&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">National Geographic. (2017, December 1). Human body 101 | National Geographic. YouTube. https:\/\/www.youtube.com\/watch?v=Ae4MadKPJC0&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4720_2803\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2803\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_713\" aria-describedby=\"caption-attachment-713\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-3168\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Cappucino-Art-by-drew-coffman-tZKwLRO904E-unsplash-scaled-1.jpg\" alt=\"\" width=\"300\" height=\"169\"><figcaption id=\"caption-attachment-713\" class=\"wp-caption-text\"><em>Figure 8.8.1 A capaccino can affect your mental state, especially when it looks like this!<\/em><\/figcaption><\/figure>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Art in a Cup<\/span><\/p>\n<p>Who knew that a cup of coffee could also be a work of art? A talented barista can make coffee look as good as it tastes. If you are a coffee drinker, you probably know that coffee can also affect your mental state. It can make you more alert, and it may improve your concentration. That\u2019s because the caffeine in coffee is a psychoactive drug. In fact, caffeine is the most widely consumed psychoactive substance in the world. In North America, for example, 90 per cent of adults consume caffeine daily.<\/p>\n<div>\n<h1>What Are Psychoactive Drugs?<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3169\">Psychoactive drugs<\/a><\/strong>\u00a0are substances that change the function of the brain and result in alterations of mood, thinking, perception, and\/or behavior. Psychoactive drugs may be used for many purposes, including therapeutic, ritual, or recreational purposes. Besides <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2560\">caffeine<\/a>, other examples of psychoactive drugs include cocaine, LSD, alcohol, tobacco, codeine, and morphine. Psychoactive drugs may be legal prescription medications (codeine and morphine), legal nonprescription drugs (alcohol and tobacco), or illegal drugs (cocaine and LSD).<\/p>\n<p>Cannabis (or marijuana) is also a psychoactive drug that while illegal in many countries is legal for use in Canada by individuals over the age of 19 years. Legal prescription medications (such as opioids) are also used illegally by increasingly large numbers of people. Some legal drugs, such as alcohol and nicotine, are readily available almost everywhere, as illustrated by the images below.<\/p>\n<div id=\"h5p-129\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-129\" class=\"h5p-iframe\" data-content-id=\"129\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Scientific Method and &quot;Doing&quot; Science\"><\/iframe><\/div>\n<\/div>\n<p><em>Figure 8.8.2 These psychoactive drugs are legal and accessible almost anywhere.\u00a0\u00a0<\/em><\/p>\n<div>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Classes of Psychoactive Drugs<\/span><\/p>\n<\/div>\n<p>Psychoactive drugs are divided into different classes\u00a0based on\u00a0their pharmacological effects. Several classes are listed below, along with examples of commonly used drugs in each class.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3171\">Stimulants<\/a><\/strong>\u00a0are drugs that stimulate the brain and increase alertness and wakefulness. Examples of stimulants include caffeine, nicotine, cocaine, and amphetamines (such as Adderall).<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3172\">Depressants<\/a><\/strong>\u00a0are drugs that calm the brain, reduce anxious feelings, and induce sleepiness. Examples of depressants include ethanol (in alcoholic beverages) and opioids, such as codeine and heroin.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3173\">Anxiolytics<\/a><\/strong>\u00a0are drugs that have a tranquilizing effect and inhibit anxiety. Examples of anxiolytic drugs include benzodiazepines (such as diazepam\/Valium), barbiturates (such as phenobarbital), opioids, and antidepressant drugs (such as sertraline\/Zoloft).<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3174\">Euphoriants<\/a><\/strong>\u00a0are drugs that bring about a state of euphoria, or intense feelings of well-being and happiness. Examples of euphoriants include the so-called \"club drug\" MDMA (ecstasy), amphetamines, ethanol, and opioids (such as morphine).<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3175\">Hallucinogens<\/a><\/strong>\u00a0are drugs that can cause hallucinations and other perceptual anomalies. They also cause subjective changes in thoughts, emotions, and consciousness. Examples of hallucinogens include LSD, mescaline, nitrous oxide, and psilocybin.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3176\">Empathogens<\/a><\/strong>\u00a0are drugs that produce feelings of empathy, or sympathy with other people. Examples of empathogens include amphetamines and MDMA.<\/li>\n<\/ul>\n<p>Many psychoactive drugs have multiple effects, so they may be placed in more than one class.\u00a0One\u00a0example is MDMA, pictured\u00a0below, which may act both as a euphoriant and as an empathogen. In some people, MDMA may also have stimulant or hallucinogenic effects. As of 2016, MDMA had no accepted medical uses, but it was undergoing testing for use in the treatment of post-traumatic stress disorder and certain other types of anxiety disorders.<\/p>\n<figure id=\"attachment_713\" aria-describedby=\"caption-attachment-713\" style=\"width: 434px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-708\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Ecstasy_monogram.jpg\" alt=\"\" width=\"434\" height=\"424\"><figcaption id=\"caption-attachment-713\" class=\"wp-caption-text\"><em>Figure 8.8.3 Ecstasy (MDMA) is most commonly taken in tablet form, like the tablets shown here.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Mechanisms of Action<\/span><\/p>\n<\/div>\n<p>Psychoactive drugs generally produce their effects by affecting brain chemistry, which in turn may cause changes in a person\u2019s mood, thinking, perception, and behavior. Each drug tends to have a specific action on one or more neurotransmitters or neurotransmitter receptors in the brain. Generally, they act as either agonists or antagonists.<\/p>\n<ul>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3178\">Agonists<\/a><\/strong>\u00a0are drugs that increase the activity of particular <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3056\">neurotransmitters<\/a>. They might act by promoting the synthesis of the neurotransmitters, reducing their reuptake from synapses, or mimicking their action by binding to receptors for the neurotransmitters.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3179\">Antagonists<\/a><\/strong>\u00a0are drugs that decrease the activity of particular neurotransmitters. They might act by interfering with the synthesis of the neurotransmitters or by blocking their receptors so the neurotransmitters cannot bind to them.<\/li>\n<\/ul>\n<p>Consider the example of the neurotransmitter <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3062\">GABA<\/a>. This is one of the most common neurotransmitters in the brain, and it normally has an inhibitory effect on\u00a0cells. GABA agonists \u2014 which increase its activity \u2014 include ethanol, barbiturates, and benzodiazepines, among other psychoactive drugs. All of these drugs work by promoting the activity of GABA receptors in the brain.<\/p>\n<div>\n<h1>Uses of Psychoactive Drugs<\/h1>\n<\/div>\n<p>You may have been prescribed psychoactive drugs by your doctor. For example, your doctor may have prescribed you\u00a0an opioid drug, such as codeine for pain (most likely in the form of Tylenol with added codeine). Chances are you also use nonprescription psychoactive drugs (like caffeine) for mental alertness. These are just two of the many possible uses of psychoactive drugs.<\/p>\n<h2>Medical Uses<\/h2>\n<figure id=\"attachment_713\" aria-describedby=\"caption-attachment-713\" style=\"width: 372px\" class=\"wp-caption alignright\"><img class=\"wp-image-709\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/US_Navy_030513-N-1577S-001_Lt._Cmdr._Joe_Casey_Ships_Anesthetist_trains_on_anesthetic_procedures_with_Hospital_Corpsman_3rd_Class_Eric_Wichman_aboard_USS_Nimitz_CVN_68.jpg\" alt=\"Anesthetic\" width=\"372\" height=\"567\"><figcaption id=\"caption-attachment-713\" class=\"wp-caption-text\"><em>Figure 8.8.4 This person is being prepared to receive a general anesthetic prior to surgery.<\/em><\/figcaption><\/figure>\n<p>General anesthesia is one use of psychoactive drugs in medicine. With general anesthesia, pain is blocked and unconsciousness is induced. General anesthetics are most often used during surgical procedures and may be administered in gaseous form, as in Figure 8.8.4. General anesthetics include the drugs halothane and ketamine. Other psychoactive drugs are used to manage pain without affecting consciousness. They may be prescribed either for acute pain in cases of trauma (such as broken bones) or for chronic pain caused by arthritis, cancer, or fibromyalgia. Most often, the drugs used for pain control are opioids, such as morphine and codeine.<\/p>\n<p>Many psychiatric disorders are also managed with psychoactive drugs. Antidepressants\u00a0like\u00a0sertraline, for example, are used to treat depression, anxiety, and\u00a0eating disorders. Anxiety disorders may also be treated with anxiolytics, such as buspirone and diazepam. Stimulants (such as amphetamines) are used to treat attention deficit disorder. Antipsychotics (such as clozapine and risperidone) \u2014 as well as mood stabilizers, such as lithium \u2014 are used to treat schizophrenia and bipolar disorder.<\/p>\n<h2>Ritual Uses<\/h2>\n<figure id=\"attachment_713\" aria-describedby=\"caption-attachment-713\" style=\"width: 278px\" class=\"wp-caption alignleft\"><img class=\" wp-image-710\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Peyote-Lophophora_williamsii_pm.jpg\" alt=\"\" width=\"278\" height=\"177\"><figcaption id=\"caption-attachment-713\" class=\"wp-caption-text\"><em>Figure 8.8.5 The peyote cactus contains a hallucinogenic drug that is still used by some Native Americans for religious rituals.<\/em><\/figcaption><\/figure>\n<p>Certain psychoactive drugs, particularly hallucinogens, have been used for ritual purposes since prehistoric times. For example, Native Americans have used the mescaline-containing peyote cactus (pictured in Figure 8.8.5) for religious ceremonies for as long as 5,700 years. In prehistoric Europe, the mushroom <em>Amanita muscaria<\/em>, which contains a hallucinogenic drug called muscimol, was used for similar purposes. Various other psychoactive drugs \u2014 including jimsonweed, psilocybin mushrooms, and cannabis \u2014 have also been used for millennia, by various peoples, for ritual purposes.<\/p>\n<p>&nbsp;<\/p>\n<div>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Recreational Uses<\/span><\/p>\n<\/div>\n<p>The recreational use of psychoactive drugs generally has the purpose of altering one\u2019s consciousness and creating a feeling of euphoria commonly called a \u201chigh.\u201d Some of the drugs used most commonly for recreational purposes are cannabis, ethanol (alcohol), opioids, and stimulants (such as nicotine). Hallucinogens are also used recreationally, primarily for the alterations they cause in thinking and perception.<\/p>\n<p>Some investigators have suggested that the urge to alter one\u2019s state of consciousness is a universal human drive, similar to the drive to satiate thirst, hunger, or sexual desire. They think that this instinct is even present in children, who may attain an altered state by repetitive motions, such as spinning or swinging. Some nonhuman animals also exhibit a drive to experience altered states. They may consume fermented berries or fruit and become intoxicated. The way cats respond to catnip (see Figure 8.8.6) is another example.<\/p>\n<figure id=\"attachment_713\" aria-describedby=\"caption-attachment-713\" style=\"width: 766px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-713\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cat-under-effects-of-catnip-by-katieb50-on-flickr.jpg\" alt=\"\" width=\"766\" height=\"574\"><figcaption id=\"caption-attachment-713\" class=\"wp-caption-text\"><em>Figure 8.8.6 This cat is taking advantage of a catnip plant and apparently enjoying its psychoactive effects.<\/em><\/figcaption><\/figure>\n<h3>Addiction, Dependence, and Rehabilitation<\/h3>\n<p>Psychoactive substances often bring about subjective changes that the user may find pleasant (euphoria) or advantageous (increased alertness). These changes are rewarding and positively reinforcing, so they have the potential for misuse, addiction, and dependence.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3184\">Addiction<\/a><\/strong>\u00a0refers to the compulsive use of a drug, despite negative consequences that such use may entail. Sustained use of an addictive drug may produce dependence on the drug.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2076\">Dependence<\/a><\/strong>\u00a0may be physical and\/or psychological. It occurs when cessation of drug use produces withdrawal symptoms. Physical dependence produces physical withdrawal symptoms, which may include tremors, pain, seizures, or insomnia. Psychological dependence produces psychological withdrawal symptoms, such as anxiety, depression, paranoia, or hallucinations.<\/p>\n<p>Rehabilitation for drug dependence and addiction typically involves psychotherapy, which may include both individual and group therapy. Organizations such as <a href=\"https:\/\/www.aa.org\/pages\/en_US\/regional-correspondent-us-and-canada\">Alcoholics Anonymous<\/a> (AA) and <a href=\"https:\/\/www.bcrna.ca\/\">Narcotics Anonymous<\/a> (NA) may also be helpful for people trying to recover from addiction. These groups are self-described as international mutual aid fellowships,\u00a0and\u00a0their primary purpose is to help addicts achieve and maintain sobriety. In some cases, rehabilitation is aided by the temporary use of psychoactive substances that reduce cravings and withdrawal symptoms without creating addiction themselves.\u00a0The drug methadone, for example, is commonly used\u00a0to treat heroin addiction.<\/p>\n<div>\n<h1>Feature: Human Biology in the News<\/h1>\n<\/div>\n<p>In North America, a lot of media attention is currently given to a rising tide of opioid addiction and overdose deaths. <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3187\">Opioids<\/a><\/strong>\u00a0are drugs derived from the opium poppy or synthetic versions of such drugs. They include the illegal drug heroin, as well as prescription painkillers such\u00a0as codeine, morphine, hydrocodone, oxycodone, and fentanyl. In 2016, fentanyl received wide media attention when it was announced that an accidental fentanyl overdose was responsible for the death of music icon Prince. Fentanyl is an extremely strong and dangerous drug, said to be 50 to 100 times stronger than morphine, making risk of overdose death from fentanyl very high.<\/p>\n<p>The dramatic increase in opioid addiction and overdose deaths has been called an opioid epidemic. It is considered to be the worst drug crisis in Canadian history. Consider the following facts:<\/p>\n<ul>\n<li>In 2016, there were almost 2,500 opioid-related deaths in Canada \u2014 almost 7 per day.<\/li>\n<li>The number of prescriptions written for opioids quadrupled between 1999 and 2010.\u00a0 If you have been prescribed codeine, fentanyl, morphine, oxycodone, hydromorphone or medical heroin, then you have been prescribed an opiate.<\/li>\n<li>There are many long-term health effects of using opioids, which include:\n<ul>\n<li>Increased tolerance to the drug.<\/li>\n<li>Liver damage.<\/li>\n<li>Substance use disorder or addiction.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>Doctors, public health professionals, and politicians have all called for new policies, funding, programs, and laws to address the opioid epidemic. Changes that have already been made include a shift from criminalizing to medicalizing the problem,\u00a0more\u00a0treatment programs, and more widespread distribution and use of the opioid-overdose antidote naloxone (Narcan). Opioids can slow or stop a person's\u00a0breathing, which is what usually causes overdose deaths. Naloxone helps the person wake up and keeps them breathing until emergency medical treatment can be provided.<\/p>\n<p>What, if anything, will work to stop the opioid epidemic in Canada and the United States? Keep watching the news to find out.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">8.8 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3169\">Psychoactive drugs<\/a> are substances that change the function of the brain and result in alterations of mood, thinking, perception, and behavior. They include prescription medications (such as opioid painkillers), legal substances (such as nicotine and alcohol), and illegal drugs (such as LSD and heroin).<\/li>\n<li>Psychoactive drugs are divided into different classes according to their pharmacological effects. They include stimulants, depressants, anxiolytics, euphoriants, hallucinogens, and empathogens. Many psychoactive drugs have multiple effects, so they may be placed in more than one class.<\/li>\n<li>Psychoactive drugs generally produce their effects by affecting brain chemistry. Generally, they act either as agonists \u2014 which enhance the activity of particular <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3056\">neurotransmitters<\/a>\u00a0\u2014 or as antagonists, which decrease the activity of particular neurotransmitters.<\/li>\n<li>Psychoactive drugs are used for various purposes, including medical,\u00a0ritual,\u00a0and recreational purposes.<\/li>\n<li>Misuse of psychoactive drugs may lead to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3184\">addiction<\/a>, which is the compulsive use of a drug despite the negative consequences such use may entail. Sustained use of an addictive drug may produce physical or psychological <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2076\">dependence<\/a> on the drug. Rehabilitation typically involves psychotherapy, and sometimes the temporary use of other psychoactive drugs.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">8.8 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What are psychoactive drugs?<\/li>\n<li>Identify six classes of psychoactive drugs, along with an example of a drug in each class.<\/li>\n<li>Compare and contrast psychoactive drugs that are agonists and\u00a0psychoactive drugs that are antagonists.<\/li>\n<li>Describe two medical uses of psychoactive drugs.<\/li>\n<li>Give an example of a ritual use of a psychoactive drug.<\/li>\n<li>Generally speaking, why do people use psychoactive drugs recreationally?<\/li>\n<li>Define addiction.<\/li>\n<li>Identify possible withdrawal symptoms associated with physical dependence on a psychoactive drug.<\/li>\n<li>Why might a person with a heroin addiction be prescribed the psychoactive drug methadone?<\/li>\n<li>The prescription drug Prozac inhibits the reuptake of the neurotransmitter serotonin, causing more serotonin to be present in the\u00a0synapse. Prozac can elevate mood, which is why it is sometimes used to treat depression. Answer the following questions about Prozac:\n<ol type=\"a\">\n<li>Is Prozac an agonist or an antagonist for serotonin? Explain your answer.<\/li>\n<li>Is Prozac a psychoactive drug? Explain your answer.<\/li>\n<\/ol>\n<\/li>\n<li>Name three classes of psychoactive drugs that include opioids.<\/li>\n<li><em>True or False:\u00a0<\/em>All psychoactive drugs are either illegal or available by prescription only.<\/li>\n<li><em>True or False:\u00a0<\/em>Anxiolytics might be prescribed by a physician.<\/li>\n<li>Name two drugs that activate receptors for the neurotransmitter GABA.\u00a0Why do you think these drugs generally have a depressant effect?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">8.8 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=foLf5Bi9qXs<\/p>\n<p style=\"text-align: center\">How does caffeine keep us awake? - Hanan Qasim, TED-Ed, 2017.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=8qK0hxuXOC8<\/p>\n<p style=\"text-align: center\">How do drugs affect the brain? - Sara Garofalo, TED-Ed, 2017.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=Nlcr1jd_Tok<\/p>\n<p style=\"text-align: center\">Is marijuana bad for your brain? - Anees Bahji, TED-Ed, 2019.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 8.8.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/tZKwLRO904E\" rel=\"cc:attributionURL\">Cappucino Art by drew-coffman-tZKwLRO904E<\/a> [photo] by <a href=\"https:\/\/unsplash.com\/@drewcoffman\">Drew Coffman<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 8.8.2<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:3804,_Saint-Laurent,_Montreal_-_Cannabis_Culture_shop.jpg\">3804, Saint-Laurent, Montreal - Cannabis Culture shop<\/a> by\u00a0<a class=\"external text\" href=\"https:\/\/www.flickr.com\/people\/29442760@N00\" rel=\"nofollow\">Exile on Ontario St<\/a> (Montreal, Canada) on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/deed.en\">CC BY SA 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by-sa\/2.0\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/theunabonger\/478021002\">Drive Through Cigarette Store<\/a> by <a class=\"owner-name truncate no-outline\" title=\"Go to Cosmo Spacely's photostream\" href=\"https:\/\/www.flickr.com\/photos\/theunabonger\/\" data-track=\"attributionNameClick\">Cosmo Spacely<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/ventriloblog\/126224469\/\">Franklin-Nicollet Liquors<\/a> by <a class=\"owner-name truncate\" title=\"Go to Max Sparber's photostream\" href=\"https:\/\/www.flickr.com\/photos\/ventriloblog\/\" data-track=\"attributionNameClick\">Max Sparber<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en) license.<\/li>\n<\/ul>\n<p><strong>Figure 8.8.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Ecstasy_monogram.jpg#file\" rel=\"cc:attributionURL\">Ecstasy_monogram<\/a> by <i><a class=\"extiw\" title=\"w:Drug Enforcement Administration\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug_Enforcement_Administration\">Drug Enforcement Administration<\/a> <\/i>on Wikimedia Commons is in the <a class=\"mw-redirect\" title=\"Public domain\" href=\"https:\/\/commons.wikimedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 8.8.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:US_Navy_030513-N-1577S-001_Lt._Cmdr._Joe_Casey,_Ship%27s_Anesthetist,_trains_on_anesthetic_procedures_with_Hospital_Corpsman_3rd_Class_Eric_Wichman_aboard_USS_Nimitz_(CVN_68).jpg\" rel=\"cc:attributionURL\">US Navy 030513-N-1577S-001 Lt. Cmdr. Joe Casey, Ship's Anesthetist, trains on anesthetic procedures with Hospital Corpsman 3rd Class Eric Wichman aboard USS Nimitz (CVN 68)<\/a> by U.S. Navy photo by Photographer\u2019s Mate Airman Timothy F. Sosais on Wikimedia Commons is in the <a class=\"mw-redirect\" title=\"Public domain\" href=\"https:\/\/commons.wikimedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 8.8.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Lophophora_williamsii_pm.jpg\" rel=\"cc:attributionURL\">Peyote Lophophora_williamsii_pm<\/a> by <a title=\"User:PeterMansfeld\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:PeterMansfeld\">Peter A. Mansfeld<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/p>\n<p><strong style=\"text-align: initial;font-size: 1em\"><br \/>\nFigure 8.8.6<\/strong><\/p>\n<section class=\"standard post-764 chapter type-chapter status-publish hentry focusable\" data-type=\"chapter\">\n<div class=\"media-atttributions\">\n<p><a href=\"https:\/\/www.flickr.com\/photos\/10233916@N03\/2526930264\/in\/photolist-3QtaE-4Zhtt7-844WT6-5HED3R-4Ribkb-6aaVt7-ekhNvK-9QFDgP-7Khsf-21p6zx-HPAcuZ-4wKSaH-RTW4nt-8KBR3K-9K4Hg2-9K7wTL-pCriyp-C4XKJ-7Q5Q-9K4HY2-6CaNK5-dZ5sqL-8yJNjk-7feRXF-JJpCF-S1Be3J-dYYKWx-dYYKTp-auB7co-7UmiU5-adcRHZ-7fiJF9-3jnSVf-9BpzN3-7fiFjb-7fiJJ1-7fiJVA-7fiJs7-dYYL96-7feRGP-dZ5sho-6KLkkz-7feRKP-7feSbx-7feSeV-7feNyR-7feRQT-7fiJMb-f87VTi-c2TF8J\" rel=\"cc:attributionURL\">Cat under effects of catnip\/Self Indulgence<\/a> by\u00a0<a href=\"https:\/\/www.flickr.com\/photos\/10233916@N03\/\" rel=\"dc:creator\">Katieb50<\/a> on <a href=\"https:\/\/www.flickr.com\/\" rel=\"cc:attributionURL\">Flickr<\/a> is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en) license.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"glossary\"><span style=\"font-size: 1.424em;font-weight: bold;color: #333333\">References<\/span><\/div>\n<div><\/div>\n<\/section>\n<p class=\"hanging-indent\">Alcoholics Anonymous World Services, Inc. (n.d.). Regional correspondent U.S. and Canada [website]. https:\/\/www.aa.org\/pages\/en_US\/regional-correspondent-us-and-canada<\/p>\n<p class=\"hanging-indent\"><span style=\"color: #373d3f;font-size: 1em;text-align: initial;text-indent: -1em\">Belzak, L., &amp; Halverson, J. (2018). The opioid crisis in Canada: a national perspective. La crise des opio\u00efdes au Canada : une perspective nationale. <\/span><i style=\"color: #373d3f;font-size: 1em;text-align: initial;text-indent: -1em\">Health promotion and chronic disease prevention in Canada : research, policy and practice<\/i><span style=\"color: #373d3f;font-size: 1em;text-align: initial;text-indent: -1em\">,\u00a0<\/span><i style=\"color: #373d3f;font-size: 1em;text-align: initial;text-indent: -1em\">38<\/i><span style=\"color: #373d3f;font-size: 1em;text-align: initial;text-indent: -1em\">(6), 224\u2013233. https:\/\/doi.org\/10.24095\/hpcdp.38.6.02<\/span><\/p>\n<p class=\"hanging-indent\">British Columbia Regional Service Committee of Narcotics Anonymous. (n.d.). Welcome to the B.C. region of N.A. [website]. https:\/\/www.bcrna.ca\/<\/p>\n<p class=\"glossary hanging-indent\"><span style=\"text-align: initial;color: #333333;font-size: 1em\">Centers for Disease Control and Prevention (CDC). (2011 November 4). <\/span>Vital signs: overdoses of prescription opioid pain relievers\u2014United States, 1999\u20132008.<span style=\"text-align: initial;color: #333333;font-size: 1em\"><em> Morbidity and Mortality Weekly Report (MMWR),<\/em><em>60<\/em>(43):1487-1492. https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm6043a4.htm<\/span><\/p>\n<p class=\"hanging-indent\"><span style=\"text-align: initial;color: #333333;font-size: 1em\">TED-Ed. (2017, June 29). How do drugs affect the brain? - Sara Garofalo. YouTube. https:\/\/www.youtube.com\/watch?v=8qK0hxuXOC8&amp;feature=youtu.be<\/span><\/p>\n<p class=\"hanging-indent\">TED-Ed. (2017, July 17). How does caffeine keep us awake? - Hanan Qasim. YouTube. https:\/\/www.youtube.com\/watch?v=foLf5Bi9qXs&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2019, December 2). Is marijuana bad for your brain? - Anees Bahji. YouTube. https:\/\/www.youtube.com\/watch?v=Nlcr1jd_Tok&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2801\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2801\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_671\" aria-describedby=\"caption-attachment-671\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-661\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Kids-piant-duet-by-PJMixer-on-Unsplash.jpg\" alt=\"\" width=\"400\" height=\"268\"><figcaption id=\"caption-attachment-671\" class=\"wp-caption-text\"><em>Figure 8.6.1 A duet with the peripheral nervous system.\u00a0<\/em><\/figcaption><\/figure>\n<h1>One Piano, Four Hands<\/h1>\n<p>Did you ever see two people play the same piano? How do they coordinate all the movements of their own fingers \u2014 let alone synchronize them with those of their partner? The peripheral nervous system plays an important part in this challenge.<\/p>\n<div>\n<h1>What Is the Peripheral Nervous System?<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3009\">peripheral nervous system<\/a> (PNS)<\/strong>\u00a0consists of all the nervous tissue that lies outside of the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2579\">central nervous system<\/a>\u00a0(CNS). The main function of the PNS is to connect the CNS to the rest of the organism. It serves as a\u00a0communication\u00a0relay, going back and forth between the CNS and\u00a0muscles, organs, and glands throughout the body.<\/p>\n<figure id=\"attachment_671\" aria-describedby=\"caption-attachment-671\" style=\"width: 421px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-663\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nervous_system_diagram.png\" alt=\"Peripheral Nervous System\" width=\"421\" height=\"695\"><figcaption id=\"caption-attachment-671\" class=\"wp-caption-text\"><em>Figure 8.6.2 The nerves of the peripheral nervous system are shown in blue in this diagram.<\/em><\/figcaption><\/figure>\n<div><\/div>\n<div>\n<h1>Tissues of the Peripheral Nervous System<\/h1>\n<\/div>\n<p>The PNS is mostly made up of cable-like bundles of axons called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3011\">nerves<\/a><\/strong>,\u00a0as well as\u00a0clusters of neuronal cell bodies called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2699\">ganglia<\/a><\/strong>\u00a0(singular,\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2701\">ganglion<\/a><\/strong>). Nerves are generally classified\u00a0as sensory, motor, or mixed nerves\u00a0based on\u00a0the direction in which they carry\u00a0nerve impulses.<\/p>\n<ul>\n<li><strong>Sensory nerves<\/strong>\u00a0transmit information from sensory receptors in the body to the CNS. Sensory nerves are also called afferent nerves. You can see an example in the figure\u00a0below.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3111\">Motor nerves<\/a><\/strong>\u00a0transmit information from the CNS to\u00a0muscles, organs, and glands. Motor nerves are also called efferent nerves. You can see one in the figure\u00a0below.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3112\">Mixed nerves<\/a><\/strong>\u00a0contain both sensory and motor neurons, so they can transmit information in both directions. They have both afferent and efferent functions.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<div>\n<figure id=\"attachment_665\" aria-describedby=\"caption-attachment-665\" style=\"width: 868px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-665\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Afferent_and_efferent_neurons_en.svg_.png\" alt=\"Afferent and Efferent Neurons\" width=\"868\" height=\"533\"><figcaption id=\"caption-attachment-665\" class=\"wp-caption-text\"><em>Figure 8.6.3 In this diagram, each nerve is depicted as a single neuron for simplicity. This afferent neuron sends nerve impulses from sensory receptors in the skin to the CNS. The efferent neuron is a motor neuron that sends nerve impulses from the CNS to a muscle. The cell body of the afferent neuron is located in a ganglion (not pictured), while the cell body of the motor neuron is located in the spinal cord.<\/em><\/figcaption><\/figure>\n<\/div>\n<div>\n<h1>Divisions of the Peripheral Nervous System<\/h1>\n<\/div>\n<p>The PNS is divided into two major systems, called the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2533\">autonomic nervous system<\/a> and the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3014\">somatic nervous system<\/a>. In the diagram\u00a0below, the autonomic system is shown on the left, and the somatic system on the right. Both systems of the PNS interact with the CNS and include sensory and motor neurons, but they use different\u00a0circuits\u00a0of nerves and ganglia.<\/p>\n<figure id=\"attachment_671\" aria-describedby=\"caption-attachment-671\" style=\"width: 1075px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-667\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Autonomic-and-Somatic-Nervous-System.png\" alt=\"Autonomic and Somatic Nervous System\" width=\"1075\" height=\"510\"><figcaption id=\"caption-attachment-671\" class=\"wp-caption-text\"><em>Figure 8.6.4 The two major divisions of the PNS are the autonomic and sensory nervous systems.<\/em><\/figcaption><\/figure>\n<h2>Somatic Nervous System<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3014\">somatic nervous system<\/a><\/strong>\u00a0primarily\u00a0senses\u00a0the external environment and controls voluntary activities about which decisions and commands come from the cerebral cortex of the brain. When you feel too warm, for example, you decide to turn on the air conditioner. As you walk across the room to the thermostat, you are using your somatic nervous system. In general, the somatic nervous system is responsible for all of your\u00a0<em>conscious<\/em>\u00a0perceptions of the outside world, as well as all of the voluntary motor activities you perform in response. Whether it\u2019s playing a piano, driving a car, or playing basketball, you can thank your somatic nervous system for making it possible.<\/p>\n<p>Somatic sensory and motor information is transmitted through\u00a012 pairs of cranial nerves and 31 pairs of spinal nerves. Cranial nerves are in the head and neck and connect directly to the brain. Sensory components of cranial nerves\u00a0transmit information about\u00a0smells, tastes, light, sounds, and body position. Motor components of cranial nerves control\u00a0skeletal muscles\u00a0of the face, tongue, eyeballs, throat, head, and shoulders. Motor components of cranial nerves also control the salivary glands and swallowing. Four of the 12 cranial nerves participate in both sensory and motor functions as mixed nerves, having both sensory and motor neurons.<\/p>\n<p>Spinal nerves emanate from the spinal column between vertebrae. All of the spinal nerves are mixed nerves, containing both sensory and motor neurons. The areas of skin innervated by the 31 pairs of spinal nerves are shown in the figure\u00a0below. These include sensory nerves in the skin that sense pressure,\u00a0temperature, vibrations, and pain. Other sensory nerves are in the\u00a0muscles, and they sense stretching and tension. Spinal nerves also include motor nerves that stimulate\u00a0skeletal muscles\u00a0to contract, allowing for voluntary body movements.<\/p>\n<figure id=\"attachment_671\" aria-describedby=\"caption-attachment-671\" style=\"width: 550px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-669\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Dermatoms.svg_.png\" alt=\"Nerves\" width=\"550\" height=\"778\"><figcaption id=\"caption-attachment-671\" class=\"wp-caption-text\"><em>Figure 8.6.5 This drawing shows the areas of the skin innervated by sensory spinal nerves of the somatic nervous system. The left half of the figure shows the nerves in the front of the body, and the right half shows the nerves in the back of the body. The area that each spinal nerve innervates is shown in a different colour.<\/em><\/figcaption><\/figure>\n<h2>Autonomic Nervous System<\/h2>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2533\">autonomic nervous system<\/a><\/strong>\u00a0primarily\u00a0senses\u00a0the internal environment and controls involuntary activities. It is responsible for monitoring conditions in the internal environment and bringing about appropriate changes in them. In general, the\u00a0autonomic\u00a0nervous system is responsible for all the activities that go on inside your body\u00a0<em>without<\/em>\u00a0your conscious awareness or voluntary participation.<\/p>\n<p>Structurally, the autonomic nervous system consists of sensory and motor nerves that run between the CNS (especially the hypothalamus in the brain), internal organs (such as the\u00a0heart, lungs, and digestive organs), and glands (such as the\u00a0pancreas\u00a0and sweat glands). <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3030\">Sensory neurons<\/a> in the autonomic system detect internal body conditions and send messages to the brain. Motor nerves in the autonomic system affect appropriate responses by controlling contractions of smooth or cardiac muscle, or glandular tissue. For example, when sensory nerves of the autonomic system detect a rise in body\u00a0temperature, motor nerves signal smooth muscles in\u00a0blood vessels\u00a0near the body surface to undergo vasodilation, and the sweat glands in the skin to secrete more sweat to cool the body.<\/p>\n<p>The autonomic nervous system, in turn, has three subdivisions: the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3015\">sympathetic division<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3016\">parasympathetic division<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2650\">enteric division<\/a>. The first two subdivisions of the autonomic system are summarized in the figure\u00a0below. Both affect the same organs and glands, but they generally do so in opposite ways.<\/p>\n<ul>\n<li>The\u00a0<strong>sympathetic division<\/strong>\u00a0controls the fight-or-flight response. Changes occur in organs and glands throughout the body that prepare the body to fight or flee in response to a perceived danger. For example, the\u00a0heart\u00a0rate speeds up, air passages in the lungs become wider, more\u00a0blood\u00a0flows to the\u00a0skeletal muscles, and the\u00a0digestive system temporarily shuts down.<\/li>\n<li>The\u00a0<strong>parasympathetic division<\/strong>\u00a0returns the body to normal after the fight-or-flight response has occurred. For example, it slows down the\u00a0heart\u00a0rate, narrows air passages in the lungs, reduces\u00a0blood\u00a0flow to the skeletal muscles, and stimulates the\u00a0digestive system\u00a0to start working again. The parasympathetic division also maintains internal\u00a0homeostasis\u00a0of the body at other times.<\/li>\n<li>The\u00a0<strong>enteric division<\/strong> is made up of nerve fibres that supply the organs of the digestive system. This division allows for the local control of many digestive functions.<\/li>\n<\/ul>\n<figure id=\"attachment_671\" aria-describedby=\"caption-attachment-671\" style=\"width: 597px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-671\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/The_Autonomic_Nervous_System.jpg\" alt=\"The autonomic nervous system\" width=\"597\" height=\"598\"><figcaption id=\"caption-attachment-671\" class=\"wp-caption-text\"><em>Figure 8.6.6 This diagram summarizes the structures and functions controlled by the parasympathetic and sympathetic divisions of the autonomic nervous system.<\/em><\/figcaption><\/figure>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Disorders of the Peripheral Nervous System<\/span><\/p>\n<p>Unlike the CNS \u2014 which is protected by\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2552\">bone<\/a>s, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2929\">meninges<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2589\">cerebrospinal fluid<\/a> \u2014 the PNS has no such protections. The PNS also has no blood-brain barrier to protect it from toxins and pathogens in the\u00a0blood. Therefore, the PNS is more subject to injury and disease than is the CNS. Causes of nerve injury include\u00a0<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/diabetes\/symptoms-causes\/syc-20371444\">diabetes<\/a>,\u00a0infectious diseases\u00a0(such as <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/shingles\/symptoms-causes\/syc-20353054\">shingles<\/a>), and poisoning by toxins (such as heavy metals). PNS disorders often have symptoms\u00a0like\u00a0loss of feeling, tingling, burning sensations, or muscle weakness. If a traumatic injury results in a nerve being transected (cut all the way through), it may regenerate, but this is a very slow process and may take many months.<\/p>\n<p>Two other diseases of the PNS are Guillain-Barre syndrome and Charcot-Marie-Tooth disease.<\/p>\n<ul>\n<li><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/guillain-barre-syndrome\/symptoms-causes\/syc-20362793\">Guillain-Barre syndrome<\/a> is a rare disease in which the immune system attacks nerves of the PNS, leading to muscle weakness and even paralysis. The exact cause of Guillain-Barre syndrome is unknown, but it often occurs after a viral or bacterial infection. There is no known cure for the syndrome, but most people eventually make a full recovery. Recovery can be slow, however, lasting anywhere from several weeks to several years.<\/li>\n<li><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/charcot-marie-tooth-disease\/symptoms-causes\/syc-20350517\">Charcot-Marie-Tooth disease<\/a> is a hereditary disorder of the nerves, and one of the most common inherited neurological disorders. It affects predominantly the nerves in the feet and legs,\u00a0and often\u00a0in the hands and arms, as well. The disease is characterized by loss of muscle tissue and sense of touch. It is presently incurable.<\/li>\n<\/ul>\n<div>\n<h1>Feature: My\u00a0Human Body<\/h1>\n<\/div>\n<p>The autonomic nervous system is considered to be involuntary because it doesn't require conscious input. However, it\u00a0<em>is<\/em>\u00a0possible to exert some voluntary control over it. People who practice yoga or other so-called mind-body techniques, for example,\u00a0can\u00a0reduce their heart rate and certain other autonomic functions. Slowing down these otherwise involuntary responses is a good way to relieve stress and reduce the wear-and-tear that stress can place on the body. Such techniques may also be useful for controlling post-traumatic stress disorder and chronic pain. Three types of integrative practices for these purposes\u00a0are\u00a0breathing exercises, body-based tension modulation exercises, and mindfulness techniques.<\/p>\n<p>Breathing exercises can help control the rapid, shallow breathing that often occurs when you are anxious or under stress. These exercises can be learned quickly, and they provide immediate feelings of relief. Specific breathing exercises include paced breath, diaphragmatic breathing, and Breathe2Relax or Chill Zone on MindShift\u2122 CBT, which are downloadable breathing practice mobile applications, or \"Apps\". Try syncing your breathing with Eric Klassen's \"Triangle breathing, 1 minute\" video:<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=u9Q8D6n-3qw<\/p>\n<p style=\"text-align: center\">Triangle breathing, 1 minute, Erin Klassen, 2015.<\/p>\n<p>Body-based tension modulation exercises include yoga postures (also known as \u201casanas\u201d) and tension manipulation exercises. The latter include the Trauma\/Tension Release\u00a0Exercise\u00a0(TRE) and the Trauma Resiliency Model (TRM). Watch this video for a brief \u2014 but informative \u2014 introduction to the TRE program:<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=67R974D8swM&amp;feature=youtu.be<\/p>\n<p style=\"text-align: center\">TRE\u00ae : Tension and Trauma Releasing Exercises, an Introduction with Jessica Schaffer, Jessica Schaffer Nervous System RESET, 2015.<\/p>\n<p>Mindfulness techniques have been shown to reduce symptoms of depression, as well as those of anxiety and stress. They have also been shown to be useful for pain management and performance enhancement. Specific mindfulness programs include Mindfulness Based Stress Reduction (MBSR) and Mindfulness Mind-Fitness Training (MMFT). You can learn more about MBSR by watching the video below.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=0TA7P-iCCcY&amp;feature=youtu.be<\/p>\n<p style=\"text-align: center\">Mindfulness-Based Stress Reduction (UMass Medical School, Center for Mindfulness), Palouse Mindfulness, 2017.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">8.6 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3009\">peripheral nervous system<\/a> (PNS) consists of all the nervous tissue that lies outside the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2579\">central nervous system<\/a> (CNS). Its main function is to connect the CNS to the rest of the organism.<\/li>\n<li>The PNS is made up of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3011\">nerves<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2699\">ganglia<\/a>. Nerves are bundles of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2535\">axons<\/a>, and ganglia are groups of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2576\">cell bodies<\/a>. Nerves are classified as sensory, motor, or a mix of the two.<\/li>\n<li>The PNS is divided into the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3014\">somatic<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2533\">autonomic nervous systems<\/a>. The somatic system controls <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3004\">voluntary<\/a> activities, whereas the autonomic system controls <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3005\">involuntary<\/a> activities.<\/li>\n<li>The autonomic nervous system is further divided into <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3015\">sympathetic<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3016\">parasympathetic<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2650\">enteric divisions<\/a>. The sympathetic division controls <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2682\">fight-or-flight responses<\/a>\u00a0during emergencies, the parasympathetic system controls routine body functions the rest of the time, and the enteric division provides local control over the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2628\">digestive system<\/a>.<\/li>\n<li>The PNS is not as well protected physically or chemically as the CNS, so it is more prone to injury and disease. PNS problems include injury from\u00a0diabetes, shingles, and heavy metal poisoning. Two disorders of the PNS are Guillain-Barre syndrome and Charcot-Marie-Tooth disease.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">8.6 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Describe the general structure of the peripheral nervous system. State its primary function.<\/li>\n<li>What are ganglia?<\/li>\n<li>Identify three types of nerves based on the direction in which they carry\u00a0nerve impulses.<\/li>\n<li>Outline all of the divisions of the peripheral nervous system.<\/li>\n<li>Compare and contrast the somatic and autonomic nervous systems.<\/li>\n<li>When and how does the sympathetic division of the autonomic nervous system affect the body?<\/li>\n<li>What is the function of the parasympathetic division of the autonomic nervous system?\u00a0Specifically, how does it affect the body?<\/li>\n<li>Name and describe two peripheral nervous system disorders.<\/li>\n<li>Give one example of how the CNS interacts with the PNS to control a function in the body.<\/li>\n<li>For each of the following types of information, identify whether the neuron carrying it is sensory or motor, and whether it is most likely in the somatic or autonomic nervous system:\n<ol type=\"a\">\n<li>Visual information<\/li>\n<li>Blood pressure information<\/li>\n<li>Information that causes muscle contraction in digestive organs after eating<\/li>\n<li>Information that causes muscle contraction in skeletal muscles based on the person\u2019s decision to make a movement<\/li>\n<\/ol>\n<\/li>\n<li>\n<div id=\"h5p-125\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-125\" class=\"h5p-iframe\" data-content-id=\"125\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"8.2 Review Questions Introduction to the Nervous System\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\" style=\"text-align: left\"><span style=\"color: #ffffff\">8.6 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=ySIDMU2cy0Y&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Phantom Limbs Explained, Plethrons, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?time_continue=1&amp;v=73yo5nJne6c&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Why Do Hot Peppers Cause Pain? Reactions, 2015.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 8.6.1<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/pjmixer\/4460758776\" rel=\"cc:attributionURL\">Kid\u2019s piant duet<\/a> by\u00a0<a href=\"https:\/\/www.flickr.com\/photos\/pjmixer\/\" rel=\"dc:creator\">PJMixer<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/\" rel=\"license\">CC BY-NC-ND 2.0<\/a>\u00a0(https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/) license.<\/p>\n<p><strong>Figure 8.6.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Nervous_system_diagram.png\" rel=\"cc:attributionURL\">Nervous_system_diagram<\/a> by <a class=\"extiw\" title=\"en:User:Persian Poet Gal\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Persian_Poet_Gal\"><span style=\"font-family: comic sans ms\"><span style=\"color: purple\">\u00a4~Persian Poet Gal<\/span><\/span><\/a>\u00a0 on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong style=\"text-align: initial;font-size: 1em\"><br \/>\nFigure 8.6.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Afferent_and_efferent_neurons_en.svg\" rel=\"cc:attributionURL\">Afferent_and_efferent_neurons_en.svg<\/a> by <a title=\"User:Helixitta\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Helixitta\">Helixitta<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0 <\/a>\u00a0 (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 8.6.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Autonomic_and_Somatic_Nervous_System.png\" rel=\"cc:attributionURL\">Autonomic and Somatic Nervous System<\/a> by <a title=\"User:Christinelmiller\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Christinelmiller\">Christinelmiller<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 8.6.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Dermatoms.svg\" rel=\"cc:attributionURL\">Dermatoms.svg<\/a> by Ralf Stephan (mailto:ralf@ark.in-berlin.de) on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 8.6.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:The_Autonomic_Nervous_System.jpg\" rel=\"cc:attributionURL\">The_Autonomic_Nervous_System<\/a> by <a title=\"User:Geo-Science-International\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Geo-Science-International\">Geo-Science-International<\/a> on Wikimedia Commons is used and adapted by Christine Miller under a\u00a0<a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"license\">CC0 1.0<\/a> Universal<br \/>\nPublic Domain Dedication license (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Erin Klassen. (2015, December 15). Triangle breathing, 1 minute. YouTube. https:\/\/www.youtube.com\/watch?v=u9Q8D6n-3qw&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Jessica Schaffer Nervous System RESET. (2015, January 15). TRE\u00ae : Tension and trauma releasing exercises, an Introduction with Jessica Schaffer. YouTube. https:\/\/www.youtube.com\/watch?v=67R974D8swM&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Charcot-Marie-Tooth disease [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/charcot-marie-tooth-disease\/symptoms-causes\/syc-20350517<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Diabetes [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/diabetes\/symptoms-causes\/syc-20371444<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Guillain-Barre syndrome [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/guillain-barre-syndrome\/symptoms-causes\/syc-20362793<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Shingles [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/shingles\/symptoms-causes\/syc-20353054<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Stroke [online article]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/stroke\/symptoms-causes\/syc-20350113<\/p>\n<p class=\"hanging-indent\">Palouse Mindfulness. (2017, March 25).\u00a0 Mindfulness-based stress reduction (UMass Medical School, Center for Mindfulness), YouTube. https:\/\/www.youtube.com\/watch?v=0TA7P-iCCcY&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Plethrons, (2015, March 23). Phantom limbs explained. YouTube. https:\/\/www.youtube.com\/watch?v=ySIDMU2cy0Y&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Reactions. (2015, December 1). Why do hot peppers cause pain? YouTube. https:\/\/www.youtube.com\/watch?v=73yo5nJne6c&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2588\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2588\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_4378\" aria-describedby=\"caption-attachment-4378\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-4378\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/aircraft-1583871_1920-1.jpg\" alt=\"14.1.1 Airplane Exercise\" width=\"400\" height=\"226\"><figcaption id=\"caption-attachment-4378\" class=\"wp-caption-text\"><em>Figure 14.1.1 Got to keep that blood moving!<\/em><\/figcaption><\/figure>\n<div>\n<h1>Case Study: Flight Risk<\/h1>\n<\/div>\n<p>Nineteen-year-old Malcolm is about to take his first plane flight. Shortly after he boards the plane and sits down, a man in his late sixties sits next to him in the aisle seat. About half an hour after the plane takes off, the pilot announces that she is turning the seat belt light off, and that it is safe to move around the cabin.<\/p>\n<p>The man in the aisle seat \u2014 who has introduced himself to Malcolm as Willie \u2014 immediately unbuckles his seat belt and paces up and down the aisle a few times before returning to his seat. After about 45 minutes, Willie gets up again, walks some more, then sits back down and does some foot and leg exercises. After the third time Willie gets up and paces the aisles, Malcolm asks him whether he is walking so much to accumulate steps on a pedometer or fitness tracking device. Willie laughs and says no. He is actually trying to do something even more important for his health \u2014 prevent a blood clot from forming in his legs.<\/p>\n<p>Willie explains that he has a chronic condition: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_4219\">heart failure<\/a>. Although it sounds scary, his condition is currently well-managed, and he is able to lead a relatively normal lifestyle. However, it <em>does<\/em> put him at risk of developing other serious health conditions, such as deep vein thrombosis (DVT), which is when a blood clot occurs in the deep veins, usually in the legs. Air travel \u2014\u00a0and\u00a0other situations where a person has to sit for a long period of time \u2014 increases the risk of DVT. Willie\u2019s doctor said that he is healthy enough to fly, but that he should walk frequently and do leg exercises to help avoid a blood clot.<\/p>\n<p>As you read this chapter, you will learn about the heart, blood vessels, and blood that make up the cardiovascular system, as well as disorders of the cardiovascular system, such as heart failure. At the end of the chapter you will learn more about why DVT occurs, why Willie has to take extra precautions when he flies, and what can be done to lower the risk of DVT and its potentially deadly consequences.<\/p>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">Chapter Overview: Cardiovascular System<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>In this chapter, you will learn about the cardiovascular system, which transports substances throughout the body. Specifically, you will learn about:<\/p>\n<ul>\n<li>The major components of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_3835\">cardiovascular system<\/a>: the heart, blood vessels, and blood.<\/li>\n<li>The functions of the cardiovascular system, including transporting needed substances (such as oxygen and nutrients) to the cells of the body, and picking up waste products.<\/li>\n<li>How blood is oxygenated through the pulmonary circulation, which transports blood between the heart and lungs.<\/li>\n<li>How blood is circulated throughout the body through the systemic circulation.<\/li>\n<li>The components of blood \u2014 including plasma, red blood cells, white blood cells, and platelets \u2014 and their specific functions.<\/li>\n<li>Types of blood vessels \u2014 including arteries, veins, and capillaries \u2014 and their functions, similarities, and differences.<\/li>\n<li>The structure of the heart, how it pumps blood, and how contractions of the heart are controlled.<\/li>\n<li>What blood pressure is and how it is regulated.<\/li>\n<li>Blood disorders, including anemia, HIV, and leukemia.<\/li>\n<li>Cardiovascular diseases (including heart attack, stroke, and angina), and the risk factors and precursors \u2014 such as high blood pressure and atherosclerosis \u2014 that contribute to them.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox shaded\">\n<p>As you read the chapter, think about the following questions:<\/p>\n<ol>\n<li>What is heart failure?Why\u00a0do you think it increases the risk of DVT?<\/li>\n<li>What is a blood clot? What are possible health consequences of blood clots?<\/li>\n<li>Why do you think sitting for long periods of time increases the risk of DVT? Why does walking and exercising the legs help reduce this risk?<\/li>\n<\/ol>\n<\/div>\n<h2>Attribution<\/h2>\n<p><strong>Figure 14.1.1<\/strong><\/p>\n<p><a href=\"https:\/\/pixabay.com\/photos\/aircraft-interior-seats-1583871\/\" rel=\"cc:attributionURL\">aircraft-1583871_1920<\/a> [photo] by <a href=\"https:\/\/pixabay.com\/users\/olivier89-3075816\/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=1583871\" rel=\"dc:creator\">olivier89<\/a> from <a href=\"http:\/\/pixabay.com\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/de\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/de\/service\/license\/).<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2905\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2905\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<div id=\"h5p-32\">\n<div class=\"h5p-content\" data-content-id=\"32\"><\/div>\n<\/div>\n<p><em>Figure 4.2.1 Human cells viewed with a very powerful tool called a scanning electron microscope.<\/em><\/p>\n<div>\n<h1>Amazing Cells<\/h1>\n<\/div>\n<p>What are these incredible objects? Would it surprise you to learn that they are all human <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cells<\/a>? Cells are actually too small to see with the unaided eye. It is visible here in such detail because it is being viewed with a very powerful\u00a0tool called a scanning electron microscope.\u00a0Cells may be small in size, but they are\u00a0<em>extremely<\/em>\u00a0important to life. Like all other living things, you are made of cells. Cells are the basis of life, and without cells, life as we know it would not exist. You will learn more about these amazing building blocks of life in this section.<\/p>\n<div>\n<h1>What Are Cells?<\/h1>\n<\/div>\n<p>If you look at living matter with a\u00a0microscope\u00a0\u2014 even a simple light microscope \u2014 you will see that it consists of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cells<\/a>. Cells are the basic units of the structure and function of living things. They are the smallest units that can carry out the processes of life. All organisms are made up of one or more cells, and all cells have many of the same structures and carry out the same basic life processes. Knowing the structure of cells and the processes they carry out is necessary to an understanding of life itself.<\/p>\n<div>\n<figure id=\"attachment_226\" aria-describedby=\"caption-attachment-226\" style=\"width: 421px\" class=\"wp-caption alignright\"><img class=\" wp-image-226\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Robert-Hookes-Diagrams.jpg\" alt=\"Diagram shows sketches from the lab journal of Robert Hooke. It includes a sketch of cork as it appeared under the microscope, a sketch of the cork tree branch his sample came from, and a sketch of the microscope apparatus he used.\" width=\"421\" height=\"247\"><figcaption id=\"caption-attachment-226\" class=\"wp-caption-text\"><em>Figure 4.2.2 Robert Hooke sketched the cork cells as they appeared under a simple light microscope.<\/em><\/figcaption><\/figure>\n<h2>Discovery of Cells<\/h2>\n<\/div>\n<p>The first time the word\u00a0<em>cell<\/em>\u00a0was used to refer to these tiny units of life was in 1665 by a British scientist named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Robert_Hooke\">Robert Hooke<\/a>.\u00a0Hooke was one of the earliest scientists to study living things under a\u00a0microscope. The microscopes of his day were not very strong, but Hooke was still able to make an important discovery. When he looked at a thin slice of cork under his microscope, he was surprised to see what looked like a honeycomb. Hooke made the drawing in the figure\u00a0to the right\u00a0to show what he saw. As you can see, the cork was made up of many tiny units. Hooke called these units\u00a0<em>cells<\/em>\u00a0because they resembled cells in a monastery.<\/p>\n<div>\n<p><span style=\"text-align: initial;font-size: 1em\">Soon after Robert Hooke discovered cells in cork, <a href=\"https:\/\/en.wikipedia.org\/wiki\/Antonie_van_Leeuwenhoek\">Anton van Leeuwenhoek<\/a> in Holland made other important discoveries using a microscope. Leeuwenhoek made his own microscope\u00a0<\/span>lenses<span style=\"text-align: initial;font-size: 1em\">, and he was so good at it that his microscope was more powerful than other microscopes of his day. In fact, Leeuwenhoek\u2019s microscope was almost as strong as\u00a0<\/span><em style=\"text-align: initial;font-size: 1em\">modern\u00a0<\/em><span style=\"text-align: initial;font-size: 1em\">light microscopes.\u00a0Using his microscope, Leeuwenhoek was the first person to observe human cells and\u00a0<\/span>bacteria<span style=\"text-align: initial;font-size: 1em\">.<\/span><\/p>\n<\/div>\n<div>\n<h2>Cell Theory<\/h2>\n<\/div>\n<p>By the early 1800s, scientists had observed cells of many different organisms. These observations led two German scientists named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Theodor_Schwann\">Theodor Schwann<\/a> and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Matthias_Jakob_Schleiden\">Matthias Jakob Schleiden<\/a> to propose\u00a0cells as\u00a0the basic building blocks of all living things. Around 1850, a German doctor named <a href=\"https:\/\/en.wikipedia.org\/wiki\/Rudolf_Virchow\">Rudolf Virchow<\/a> was studying cells under a microscope, when he happened to see them dividing and forming new cells. He realized that living cells produce new cells through division. Based on this realization, Virchow proposed that living cells arise only from other living cells.<\/p>\n<p>The ideas of all three scientists \u2014 Schwann, Schleiden, and Virchow \u2014 led to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2302\">cell theory<\/a>, which is one of the fundamental\u00a0theories\u00a0unifying all of biology.<\/p>\n<p>Cell theory states that:<\/p>\n<ul>\n<li>All organisms are made of one or more cells.<\/li>\n<li>All the life functions of organisms occur within cells.<\/li>\n<li>All cells come from existing cells.<\/li>\n<\/ul>\n<div>\n<h2>Seeing Inside Cells<\/h2>\n<\/div>\n<p>Starting with Robert Hooke in the 1600s, the microscope opened up an amazing new world \u2014\u00a0a\u00a0world of life at the level of the cell. As microscopes continued to improve, more discoveries were made about the cells of living things, but by the late 1800s, light microscopes had reached their limit. Objects much smaller than cells (including the structures inside cells) were too small to be seen with even the strongest light microscope.<\/p>\n<figure id=\"attachment_228\" aria-describedby=\"caption-attachment-228\" style=\"width: 357px\" class=\"wp-caption alignleft\"><img class=\"wp-image-227\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Electron-Microscope-image-of-a-cell.jpg\" alt=\"\" width=\"357\" height=\"285\"><figcaption id=\"caption-attachment-228\" class=\"wp-caption-text\"><em>Figure 4.2.3 An electron microscope produced this image of the structures inside of a cell.<\/em><\/figcaption><\/figure>\n<p>Then, in the 1950s, a new type of microscope was invented. Called the\u00a0electron\u00a0microscope, it used a beam of electrons instead of light to observe extremely small objects. With an electron microscope, scientists could finally see the tiny structures inside cells. They could even see individual molecules and atoms. The electron microscope had a huge impact on biology. It allowed scientists to study organisms at the level of their molecules, and it led to the emergence of the molecular biology field. With the electron microscope, many more cell discoveries were made.<\/p>\n<div>\n<h2>Structures Shared By All Cells<\/h2>\n<\/div>\n<p>Although cells are diverse, all cells have certain parts in common. These parts include a\u00a0plasma membrane, cytoplasm, ribosomes, and\u00a0DNA.<\/p>\n<figure id=\"attachment_228\" aria-describedby=\"caption-attachment-228\" style=\"width: 447px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-228\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Basic-Components-of-a-cell.png\" alt=\"Image shows a diagram of a cell containing the four basic components of a cell: a plasma membrane, DNA, ribosomes and a cytoplasm.\" width=\"447\" height=\"344\"><figcaption id=\"caption-attachment-228\" class=\"wp-caption-text\"><em>Figure 4.2.4 Every cell consists of at least a plasma membrane, DNA, ribosomes and a cytoplasm.<\/em><\/figcaption><\/figure>\n<ol>\n<li>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a><\/strong>\u00a0(a type of\u00a0cell membrane) is a thin coat of\u00a0lipids\u00a0that surrounds a cell. It forms the physical boundary between the cell and its environment. You can think of it as the \u201cskin\u201d of the cell.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1963\">Cytoplasm<\/a><\/strong>\u00a0refers to all of the cellular material inside of the\u00a0plasma membrane. Cytoplasm is made up of a watery substance called cytosol, and it contains other cell structures, such as ribosomes.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">Ribosomes<\/a><\/strong>\u00a0are the structures in the cytoplasm\u00a0in which\u00a0proteins\u00a0are made.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_277\">DNA<\/a><\/strong>\u00a0is a\u00a0nucleic acid\u00a0found in cells. It contains the genetic instructions that cells need to make\u00a0proteins.<\/li>\n<\/ol>\n<p>These four parts are common to\u00a0<em>all<\/em>\u00a0cells, from organisms as different as\u00a0bacteria\u00a0and human beings. How did all known organisms come to have such similar cells? The similarities show that all life on Earth has a common evolutionary history.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.2 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">Cells<\/a> are the basic units of structure and function in living things. They are the smallest units that can carry out the processes of life.<\/li>\n<li>In the 1600s, Hooke was the first to observe cells from an organism (cork). Soon after, microscopist van Leeuwenhoek observed many other living cells.<\/li>\n<li>In the early 1800s, Schwann and Schleiden theorized that cells are the basic building blocks of all living things. Around 1850, Virchow\u00a0observed\u00a0cells dividing. To previous learnings, he added that living cells arise only from other living cells. These ideas led to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2302\">cell theory<\/a>, which states that all organisms are made of cells, that all life functions occur in cells, and that all cells come from other cells.<\/li>\n<li>It wasn't until the 1950s that scientists could see what was inside the cell. The invention of the\u00a0electron\u00a0microscope allowed them to see\u00a0organelles\u00a0and other structures smaller than cells.<\/li>\n<li>There is\u00a0variation in cells, but all cells have a plasma membrane, cytoplasm, ribosomes, and\u00a0DNA. These similarities show that all life on Earth has a common ancestor in the distant past.<\/li>\n<\/ul>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.2 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Describe cells.<\/li>\n<li>Explain how cells were discovered.<\/li>\n<li>Outline\u00a0the\u00a0development\u00a0of cell theory.<\/li>\n<li>\n<div id=\"h5p-33\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-33\" class=\"h5p-iframe\" data-content-id=\"33\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Cells\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Identify the structures shared by all cells.<\/li>\n<li>Proteins are made on _____________ .<\/li>\n<li>\n<div id=\"h5p-34\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-34\" class=\"h5p-iframe\" data-content-id=\"34\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Contributors to Cell Theory\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Robert Hooke sketched what looked like honeycombs \u2014 or repeated circular or square units \u2014 when he observed plant cells under a microscope.\n<ol type=\"\">\n<li>What is each unit?<\/li>\n<li>Of the shared parts of all cells, what makes up the outer surface of each unit?<\/li>\n<li>Of the shared parts of all cells, what makes up the inside of each unit?<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.2 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=8IlzKri08kk<\/p>\n<p style=\"text-align: center\">Introduction to Cells: The Grand Cell Tour, by The Amoeba Sisters, 2016.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.2.1<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=18129\">A white blood cell (WBC) known as a neutrophil<\/a> by National Institute of Allergy and Infectious Diseases (NIAID) on the CDC\/ Public Health Image Library (PHIL) Photo ID# 18129. is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/niaid\/5950870236\/\">Healthy Human T Cell\u00a0<\/a> by <a class=\"owner-name truncate\" title=\"Go to NIAID's photostream\" href=\"https:\/\/www.flickr.com\/photos\/niaid\/\" data-track=\"attributionNameClick\">NIAID<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a>. is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/niaid\/29228845335\/\">Human natural killer cell<\/a> by <a class=\"owner-name truncate\" title=\"Go to NIAID's photostream\" href=\"https:\/\/www.flickr.com\/photos\/niaid\/\" data-track=\"attributionNameClick\">NIAID<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a>. is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/zeissmicro\/14255918978\">Human blood with red blood cells, T cells (orange) and platelets (green)<\/a> by <a class=\"owner-name truncate\" title=\"Go to ZEISS Microscopy's photostream\" href=\"https:\/\/www.flickr.com\/photos\/zeissmicro\/\" data-track=\"attributionNameClick\">ZEISS Microscopy<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a>. is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/\">CC BY-NC-ND 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/zeissmicro\/14256058429\">Developing nerve cells\u00a0<\/a> by <a class=\"owner-name truncate\" title=\"Go to ZEISS Microscopy's photostream\" href=\"https:\/\/www.flickr.com\/photos\/zeissmicro\/\" data-track=\"attributionNameClick\">ZEISS Microscopy<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a>. is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/\">CC BY-NC-ND 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/2.0\/) license.<\/li>\n<\/ul>\n<p><strong>Figure 4.2.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Hooke-Microscope-cork.jpg\" rel=\"cc:attributionURL\">Hooke-microscope-cork<\/a> by Robert Hooke (1635-1702) [uploaded by <a title=\"User:Alejandro Porto\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Alejandro_Porto\">Alejandro Porto]<\/a> on Wikimedia Commons is released into the <a class=\"mw-redirect\" title=\"Public domain\" href=\"https:\/\/commons.wikimedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.2.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Chlamydomonas_TEM_07.jpg\" rel=\"cc:attributionURL\">Electron Microscope image of a cell<\/a> by Dartmouth Electron Microscope Facility, Dartmouth College on Wikimedia Commons is released into the <a class=\"mw-redirect\" title=\"Public domain\" href=\"https:\/\/commons.wikimedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.2.4<\/strong><\/p>\n<p>Basic-Components-of-a-cell by Christine Miller is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"license\">CC0 1.0<\/a> (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2016, November 1). Introduction to cells: The grand cell tour. YouTube. https:\/\/www.youtube.com\/watch?v=8IlzKri08kk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">National Institute of Allergy and Infectious Diseases (NIAID). (2011). A white blood cell (WBC) known as a neutrophil, as it was in the process of ingesting a number of spheroid shaped, methicillin-resistant, Staphylococcus aureus (MRSA) bacteria [digital image]. CDC\/ Public Health Image Library (PHIL) Photo ID# 18129. https:\/\/phil.cdc.gov\/Details.aspx?pid=18129.<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 24). Antonie van Leeuwenhoek. In\u00a0<i>Wikipedia<\/i>.\u00a0 https:\/\/en.wikipedia.org\/w\/index.php?title=Antonie_van_Leeuwenhoek&amp;oldid=964339564<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, May 25). Matthias Jakob Schleiden. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Matthias_Jakob_Schleiden&amp;oldid=958819219<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 4). Rudolf Virchow. In\u00a0<i>Wikipedia,. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Rudolf_Virchow&amp;oldid=960708716<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, May 16). Theodor Schwann. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Theodor_Schwann&amp;oldid=956919239<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2906\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2906\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<div>\n<figure id=\"attachment_231\" aria-describedby=\"caption-attachment-231\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-231\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Borrelia_hermsii_Bacteria_13758011613.jpg\" alt=\"Image shows a large red blood cell, with a filamentous green bacterium resting on its surface.\" width=\"400\" height=\"300\"><figcaption id=\"caption-attachment-231\" class=\"wp-caption-text\"><em>Figure 4.3.1 A bacterium attacks a human erythrocyte. Both are cells.<\/em><\/figcaption><\/figure>\n<h1>Bacteria\u00a0Attack!<\/h1>\n<\/div>\n<p>The colourful image in Figure 4.3.1 shows a bacterial cell (in green) attacking human red blood cells. The bacterium causes a disease called relapsing fever. The bacterial and human cells look very different in size and shape. Although all living cells have certain things in common \u2014 such as a plasma membrane and cytoplasm \u2014 different types of cells, even within the same organism, may have their own unique structures and functions. Cells with different functions generally have different shapes that suit them for their particular job. Cells vary not only in shape, but also in size, as this example shows. In most organisms, however, even the largest cells are no bigger than the period at the end of this sentence. Why are cells so small?<\/p>\n<div>\n<h1>Explaining Cell Size<\/h1>\n<\/div>\n<p>Most organisms, even very large ones, have microscopic cells. Why don't cells get bigger instead of remaining tiny and multiplying? Why aren't you one giant cell rolling around school? What limits cell size?<\/p>\n<p>Once you know how a cell functions, the answers to these questions are clear. To carry out life processes, a cell must be able to quickly pass substances in and out of the cell. For example, it must be able to pass\u00a0nutrients\u00a0and oxygen into the cell and waste products out of the cell. Anything that enters or leaves a cell must cross its outer surface. The size of a cell is limited by its need to pass substances across that outer surface.<\/p>\n<p>Look at the three cubes in Figure 4.3.2. A<span style=\"text-align: initial;font-size: 1em\"> larger cube has less surface area relative to its volume than a smaller cube. This relationship also applies to cells \u2014 a larger cell has less surface area relative to its volume than a smaller cell. A cell with a larger volume also needs more nutrients and oxygen, and produces more waste. Because all of these substances must pass through the surface of the cell, a cell with a large volume will not have enough surface area to allow it to meet its needs. The <\/span><em style=\"text-align: initial;font-size: 1em\">larger<\/em><span style=\"text-align: initial;font-size: 1em\"> the cell is, the <\/span><em style=\"text-align: initial;font-size: 1em\">smaller<\/em><span style=\"text-align: initial;font-size: 1em\"> its ratio of surface area to volume, and the more difficult it will be for the cell to get rid of its waste and take in necessary substances. This is what limits the size of the cell.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_234\" aria-describedby=\"caption-attachment-234\" style=\"width: 741px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-232\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cell-Size.png\" alt=\"Image shows three cubes: a small, a medium and a large. The cube with length of 1 has a surface area to volume ratio of 6:1. The cube with a length of 2 has a surface area to volume ratio of 3:1 and the cube with the length of 3 has a surface area to volume ratio of 2:1.\" width=\"741\" height=\"556\"><figcaption id=\"caption-attachment-234\" class=\"wp-caption-text\"><em>Figure 4.3.2 Surface area to volume ratio.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Cell Form and Function<\/h1>\n<\/div>\n<p>Cells with different functions often have varying shapes. The cells pictured below (Figure 4.3.3) are just a few examples of the many different shapes that human cells may have. Each type of cell\u00a0 has characteristics that help it do its job. The job of the nerve cell, for example, is to carry messages to other cells. The nerve cell has many long extensions that reach out in all directions, allowing it to pass messages to many other cells at once. Do you see the tail of each tiny sperm cell? Its tail helps a sperm cell \"swim\" through fluids in the female reproductive tract in order to reach an egg cell. The white blood cell has the job of destroying bacteria and other pathogens. It is a large cell that can engulf foreign invaders.<\/p>\n<div>\n<div id=\"h5p-35\">\n<div class=\"h5p-content\" data-content-id=\"35\"><\/div>\n<\/div>\n<p><em>Figure 4.3.3 Human cells may have many different shapes that help them to do their jobs.<\/em><\/p>\n<\/div>\n<div>\n<h1>Cells With and Without a\u00a0Nucleus<\/h1>\n<\/div>\n<p>The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a>\u00a0is a basic\u00a0cell structure\u00a0present in many \u2014 but not\u00a0<em>all \u2014<\/em>\u00a0living cells. The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a>\u00a0of a cell is a structure in the cytoplasm that is surrounded by a membrane (the nuclear membrane) and contains\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_277\">DNA<\/a>. Based on whether or not they have a nucleus, there are two basic types of cells: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1572\">prokaryotic<\/a> cells and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> cells.<\/p>\n<h2>Prokaryotic Cells<\/h2>\n<figure id=\"attachment_234\" aria-describedby=\"caption-attachment-234\" style=\"width: 392px\" class=\"wp-caption alignright\"><img class=\"wp-image-233\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2000px-Average_prokaryote_cell-_en.svg_.png\" alt=\"Image shows a diagram of a bacterium. The bacterium is smaller than a typical eukaryotic cell, has fewer organelles and contains no membrane-bound organelles.\" width=\"392\" height=\"319\"><figcaption id=\"caption-attachment-234\" class=\"wp-caption-text\"><em>Figure 4.3.3 Bacteria are prokaryotes, meaning they do not have a nucleus. Their DNA is contained in a region called the nucleoid.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1572\">Prokaryotic<\/a> cells<\/strong> are cells without a nucleus. The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_277\">DNA<\/a> in prokaryotic cells is in the cytoplasm, rather than enclosed within a nuclear membrane.\u00a0 In addition, these cells are typically smaller than eukaryotic cells and contain fewer organelles.\u00a0 Prokaryotic cells are found in single-celled organisms, such as the bacterium represented by the model in Figure 4.3.3. Organisms with prokaryotic cells are called <strong>prokaryotes<\/strong>. They were the first type of organisms to evolve, and they are still the most common organisms today.<\/p>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Eukaryotic Cells<\/h2>\n<figure id=\"attachment_234\" aria-describedby=\"caption-attachment-234\" style=\"width: 2500px\" class=\"wp-caption alignnone\"><img class=\"size-full wp-image-234\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Animal-Cell-1.png\" alt=\"Image shows a diagram of a eukaryotic cell. The cell has many organelles labelled, including: nucleus, nucleolus, rough endoplasmic reticulum, smooth endoplasmic reticulum, Golgi body, vesicles, mitochondria and centrioles.\" width=\"2500\" height=\"1000\"><figcaption id=\"caption-attachment-234\" class=\"wp-caption-text\"><em>Figure 4.3.4 Eukaryotic cells, like this animal cell, contain a nucleus and many other membrane-bound organelles.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">Eukaryotic<\/a> cells<\/strong> are cells that contain a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a>. A typical eukaryotic cell is represented by the model in Figure 4.3.4. Eukaryotic cells are usually larger than prokaryotic cells. They are found in some single-celled and all multicellular organisms. Organisms with eukaryotic cells are called <strong>eukaryotes<\/strong>, and they range from\u00a0fungi\u00a0to\u00a0humans.<\/p>\n<p>Besides a nucleus, eukaryotic cells also contain other\u00a0organelles. An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2083\">organelle<\/a><\/strong>\u00a0is a structure within the cytoplasm that performs a specific job in the cell.\u00a0Organelles\u00a0called\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2383\">mitochondria<\/a>, for example, provide\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a>\u00a0to the cell, and organelles called vesicles store substances in the cell. Organelles allow <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> cells to carry out more functions than <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1572\">prokaryotic<\/a> cells can.<\/p>\n<p>Interestingly, scientists think that mitochondria were once free-living prokaryotes that infected (or were engulfed by) larger cells. The two organisms developed a symbiotic relationship that was beneficial to both of them, resulting in the smaller prokaryote becoming an organelle within the larger cell. This is called endosymbiotic theory, and it is supported by a lot of evidence, including the fact that <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2383\">mitochondria<\/a> have their own <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_277\">DNA<\/a> separate from the DNA in the nucleus of the eukaryotic cell. Endosymbiotic theory will be described in more detail in later sections, and it's also discussed in the video below.<\/p>\n<div>\n<p>https:\/\/www.youtube.com\/watch?v=FGnS-Xk0ZqU<\/p>\n<p class=\"title style-scope ytd-video-primary-info-renderer\" style=\"text-align: center\">Endosymbiotic Theory, Amoeba Sisters, 2017.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\">4.3 Summary<\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Cells must be very small so they have a large enough surface area-to-volume ratio to maintain normal cell processes.<\/li>\n<li>Cells with different functions often have different shapes.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1572\">Prokaryotic<\/a> cells do not have a nucleus. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">Eukaryotic <\/a>cells\u00a0<em>do<\/em>\u00a0have a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a>, along with other\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2083\">organelles<\/a>.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Explain why most cells are very small.<\/li>\n<li>Discuss variations in the form and function of cells.<\/li>\n<li>\n<div id=\"h5p-36\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-36\" class=\"h5p-iframe\" data-content-id=\"36\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Cell Variation\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>\n<div id=\"h5p-37\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-37\" class=\"h5p-iframe\" data-content-id=\"37\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Prokaryote vs. Eukaryote T\/F\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Do human cells have organelles? Explain your answer.<\/li>\n<li>Which are usually larger \u2013 prokaryotic or eukaryotic cells? What do you think this means for their relative ability to take in needed substances and release wastes? Discuss your answer.<\/li>\n<li>DNA in eukaryotes is enclosed within the _______ \u00a0________.<\/li>\n<li>Name three different types of cells in humans.<\/li>\n<li>Which organelle provides energy in eukaryotic cells?<\/li>\n<li>What is a function of a vesicle in a cell?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.3 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?time_continue=1&amp;v=9i7kAt97XYU&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">How we think complex cells evolved - Adam Jacobson, TED-Ed, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=Pxujitlv8wc<\/p>\n<p style=\"text-align: center\">Prokaryotic vs. Eukaryotic Cells (updated), Amoeba Sisters, 2018.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.3.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Borrelia_hermsii_Bacteria_(13758011613).jpg\" rel=\"cc:attributionURL\">Borrelia_hermsii_Bacteria_(13758011613)<\/a> by <a href=\"https:\/\/www.flickr.com\/people\/54591706@N02\">NAID<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.3.2<\/strong><\/p>\n<p>Cell Size by Christine Miller is released into the <a href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">Public Domain<\/a> (https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/).<\/p>\n<p><strong>Figure 4.3.3<\/strong><\/p>\n<ul>\n<li><a style=\"font-size: 1em\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:BioTek-Wikipedia-Image.tif\">Chondrocyte. BioTek-Wikipedia-Image<\/a><span style=\"font-size: 1em\"> by BioTek Instruments, Inc. on Wikimedia Commons is used under a <\/span><a style=\"font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY-SA 3.0<\/a><span style=\"font-size: 1em\"> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en) license. <\/span><\/li>\n<li><a style=\"font-size: 1em\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Neutrophil_with_anthrax_copy.jpg\">Neutrophil with anthrax copy<\/a><span style=\"font-size: 1em\"> by Volker Brinkmann from <\/span><a style=\"font-size: 1em\" href=\"https:\/\/journals.plos.org\/plospathogens\/issue?id=10.1371\/issue.ppat.v01.i03\">PLOS Pathogens<\/a><span style=\"font-size: 1em\"> on Wikimedia Commons is used under a\u00a0<\/span><a style=\"font-size: 1em\" href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en\">CC BY 2.5<\/a><span style=\"font-size: 1em\"> (https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en) license.\u00a0<\/span><\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:PLoSBiol4.e126.Fig6fNeuron.jpg\"><em>PLoSBio<\/em>l4.e126.Fig6fNeuron<\/a> by Lee, et al. from <a href=\"https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.0040029\">PLOS Biology<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en\">CC BY 2.5<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Sperm_(265_33)_human.jpg\">Sperm (265 33) human<\/a> by <a class=\"extiw\" title=\"cs:Josef Reischig\" href=\"https:\/\/cs.wikipedia.org\/wiki\/Josef_Reischig\">Doc. RNDr. Josef Reischig, CSc.<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license.<\/li>\n<\/ul>\n<\/div>\n<p><strong style=\"text-align: initial;font-size: 1em\"><br \/>\nFigure 4.3.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Average_prokaryote_cell-_en.svg\" rel=\"cc:attributionURL\">Model of a prokaryotic cell: bacterium<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.3.5<\/strong><\/p>\n<p>Animal Cell adapted by Christine Miller is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"license\">CC0 1.0<\/a> (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) public domain dedication license. (Original image, <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Animal_Cell_Unannotated.svg\">Animal Cell Unannotated,<\/a> is by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kelvin13\">Kelvin Song<\/a> on Wikimedia Commons.)<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2017, May 3). Endosymbiotic theory. YouTube. https:\/\/www.youtube.com\/watch?v=FGnS-Xk0ZqU&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Amoeba Sisters. (2018, July 30). Prokaryotic vs. eukaryotic cells (updated). YouTube. https:\/\/www.youtube.com\/watch?v=Pxujitlv8wc&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Brinkmann, V. (November 2005). Neutrophil engulfing Bacillus anthracis. <em>PLoS Pathogens 1<\/em> (3): Cover page [digital image]. DOI:10.1371. https:\/\/journals.plos.org\/plospathogens\/issue?id=10.1371\/issue.ppat.v01.i03<\/p>\n<p class=\"hanging-indent\">Lee, W.C.A., Huang, H., Feng, G., Sanes, J.R., Brown, E.N., et al. (2005, December 27) Figure 6f, slightly altered (plus scalebar, minus letter \"f\".) [digital image]. Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex. <em>PLoS Biology, 4<\/em>(2), e29. doi:10.1371\/journal.pbio.0040029. https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.0040029<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2015, February 17). How we think complex cells evolved - Adam Jacobson. https:\/\/www.youtube.com\/watch?v=9i7kAt97XYU&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2907\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2907\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_243\" aria-describedby=\"caption-attachment-243\" style=\"width: 373px\" class=\"wp-caption alignnone\"><img class=\"wp-image-237\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Animal_Cell_Unannotated.svg_.png\" alt=\"\" width=\"373\" height=\"216\"><figcaption id=\"caption-attachment-243\" class=\"wp-caption-text\"><em>Figure 4.4.1 Simple cut-away model of an animal cell.\u00a0<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_243\" aria-describedby=\"caption-attachment-243\" style=\"width: 368px\" class=\"wp-caption alignnone\"><img class=\"wp-image-238\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/jello-mold.jpg\" alt=\"\" width=\"368\" height=\"245\"><figcaption id=\"caption-attachment-243\" class=\"wp-caption-text\"><em>Figure 4.4.2 Jello molds containing fruit. <\/em><\/figcaption><\/figure>\n<div>\n<h1>A Bag Full of Jell-O<\/h1>\n<\/div>\n<p>The simple cut-away model of an animal <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cell<\/a> (Figure 4.4.1) shows that a cell resembles a plastic bag full of Jell-O. Its basic structure is a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a> filled with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1963\">cytoplasm<\/a>. Like Jell-O containing mixed fruit (Figure 4.4.2), the cytoplasm of the cell also contains various structures, including a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a> and other <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2083\">organelles<\/a>. Your body is composed of trillions of cells, but all of them perform the same basic life functions. They all obtain and use <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a>, respond to the environment, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2414\">reproduce<\/a>. How do your cells carry out these basic functions and keep themselves \u2014 and you \u2014 alive? To answer these questions, you need to know more about the structures that make up cells, starting with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a>.<\/p>\n<div>\n<h1><strong>What is<\/strong> the<strong> Plasma Membrane?<\/strong><\/h1>\n<\/div>\n<p>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a> is a structure that forms a barrier between the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1963\">cytoplasm<\/a> inside the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cell<\/a> and\u00a0the environment\u00a0outside the cell. Without the plasma membrane, there would be no cell.\u00a0Although it is very thin and flexible, the plasma membrane protects and supports the cell by controlling everything that enters and leaves it.\u00a0It allows only certain substances to pass through, while keeping others in or out. To understand how the plasma membrane controls what passes into or out of the cell, you need to know its basic structure.<\/p>\n<div>\n<h2>Phospholipid Bilayer<\/h2>\n<\/div>\n<p>The plasma membrane is composed mainly of\u00a0phospholipids, which consist of fatty acids and alcohol. The phospholipids in the plasma membrane are arranged in two layers, called a\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2137\">phospholipid bilayer<\/a><\/strong>. As shown in the simplified diagram in Figure 4.4.3, each individual\u00a0 phospholipid molecule has a phosphate group head (in red) and two fatty acid tails (in yellow). The head \u201cloves\u201d water (<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2240\">hydrophilic<\/a>) and the tails \u201chate\u201d water (<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2237\">hydrophobic<\/a>). The water-hating tails are on the interior of the membrane, whereas the water-loving heads point outward, toward either the cytoplasm (intracellular) or the fluid that surrounds the cell (extracellular).<\/p>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2237\">Hydrophobic<\/a> molecules can easily pass through the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a> if they are small enough, because they are water-hating like the interior of the membrane. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2240\">Hydrophilic<\/a> molecules, on the other hand, <em>cannot<\/em> pass through the plasma membrane \u2014 at least not without help \u2014 because they are water-loving like the exterior of the membrane.<\/p>\n<figure id=\"attachment_243\" aria-describedby=\"caption-attachment-243\" style=\"width: 457px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-1592\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Phospholipid_Bilayer-1.jpg\" alt=\"Image shows a diagram of a phospholipid bilayer. The bilayer is made up of two sheets of phospholipids, with the fatty acid tails facing towards the center, and the phosphate heads on the two external surfaces.\" width=\"457\" height=\"308\"><figcaption id=\"caption-attachment-243\" class=\"wp-caption-text\"><em>Figure 4.4.3 The phospholipid bilayer is made up of two sheets of phospholipids, with the fatty acid tails facing the centre.<\/em><\/figcaption><\/figure>\n<div>\n<h2>Other Molecules in the Plasma Membrane<\/h2>\n<\/div>\n<p>The plasma membrane also contains other molecules, primarily other <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2205\">lipids<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2422\">proteins<\/a>. The yellow molecules in the diagram here, for example, are the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2205\">lipid<\/a> cholesterol. Molecules of the steroid lipid cholesterol help the plasma membrane keep its shape. Proteins in the plasma membrane (shown blue in Figure 4.4.4) include: transport <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2422\">proteins<\/a> that assist other substances in crossing the cell membrane, receptors that allow the cell to respond to chemical signals in its environment, and cell-identity markers that indicate what type of cell it is and whether it belongs in the body.<\/p>\n<figure id=\"attachment_243\" aria-describedby=\"caption-attachment-243\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-240\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lipid-bilayer.jpg\" alt=\"Image shows a diagram of a plasma membrane. The lipid bilayer contains embedded molecules including proteins, glycoproteins, glycolipids, and cholesterol.\" width=\"610\" height=\"279\"><figcaption id=\"caption-attachment-243\" class=\"wp-caption-text\"><em>Figure 4.4.4 The plasma membrane contains many molecules embedded in the lipid bilayer.<\/em><\/figcaption><\/figure>\n<div>\n<h2>Additional Functions of the Plasma Membrane<\/h2>\n<\/div>\n<p>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a> may have extensions, such as whip-like <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2151\">flagella<\/a> (singular flagellum) or brush-like <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1597\">cilia<\/a> (singular cilium), shown below (Figure 4.4.5), that give it other functions. In single-celled organisms, these membrane extensions may help the organisms move. In multicellular organisms, the extensions have different functions. For example, the cilia on human lung cells sweep foreign particles and mucus toward the mouth and nose, while the flagellum on a human sperm cell allows it to swim.<\/p>\n<figure id=\"attachment_243\" aria-describedby=\"caption-attachment-243\" style=\"width: 379px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-241\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Spermatozoa-human-3140x.jpg\" alt=\"Image shows a scanning electron microscope image of three human sperm on a porous surface.\" width=\"379\" height=\"265\"><figcaption id=\"caption-attachment-243\" class=\"wp-caption-text\"><em>Figure 4.4.5 Human sperm with their long, whip-like flagella.<\/em><\/figcaption><\/figure>\n<figure id=\"attachment_243\" aria-describedby=\"caption-attachment-243\" style=\"width: 369px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-242\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cilia.jpg\" alt=\"Image shows a scanning electron microscope image of the interior surface of bronchi. The cells lining the interior of this tube have clumps of cilia.\" width=\"369\" height=\"378\"><figcaption id=\"caption-attachment-243\" class=\"wp-caption-text\"><em>Figure 4.4.6 Brush-like cilia on lung epithelial cells.<\/em><\/figcaption><\/figure>\n<div>\n<p><strong>Feature: My\u00a0<\/strong><strong>Human Body<\/strong><\/p>\n<\/div>\n<p>If you smoke or use e-cigarettes (vaping) and need another reason to quit, here's a good one.\u00a0We usually think of lung\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2148\">cancer<\/a>\u00a0as the major disease caused by smoking. But smoking and vaping can have devastating effects on the body's ability to protect itself from repeated, serious respiratory infections, such as bronchitis and pneumonia.<\/p>\n<figure id=\"attachment_243\" aria-describedby=\"caption-attachment-243\" style=\"width: 672px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-243\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/1024px-Adverse_effects_of_vaping_raster.png\" alt=\"4.4.7 Adverse Affects of Vaping\" width=\"672\" height=\"910\"><figcaption id=\"caption-attachment-243\" class=\"wp-caption-text\"><em>Figure 4.4.7 Airways of \u201chealthy\u201d vapors are abnormal - results of vaping.<\/em><\/figcaption><\/figure>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1597\">Cilia<\/a> are microscopic, hair-like projects on\u00a0cells\u00a0that line the respiratory, reproductive, and digestive systems. Cilia in the\u00a0respiratory system\u00a0line most of your airways, where they have the job of trapping and removing dust, germs, and other foreign particles before they can make you sick. Cilia secrete mucus that traps particles, and they move in a continuous wave-like motion that sweeps the mucus and particles upward toward the throat, where they can be expelled from the body. When you are sick and cough up phlegm, that's what you are doing.<\/p>\n<p>Smoking prevents cilia from performing these important functions. Chemicals in tobacco smoke paralyze the cilia so they can't sweep mucus out of the airways. Those chemicals also inhibit the cilia from producing mucus. Fortunately, these effects start to wear off soon after the\u00a0most recent\u00a0exposure to tobacco smoke. If you stop smoking, your cilia will return to normal. Even if prolonged smoking has destroyed cilia, they will regrow and resume functioning in a matter of months after you stop smoking.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.4 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a> is a structure that forms a barrier between the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1963\">cytoplasm<\/a> inside the cell and\u00a0the environment\u00a0outside the cell. It allows only certain substances to pass in or out of the cell.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a> is composed mainly of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2137\">bilayer of phospholipid<\/a> molecules. It also contains other molecules, such as the steroid cholesterol, which helps the membrane keep its shape, and transport proteins, which help substances pass through the membrane.<\/li>\n<li>The\u00a0plasma\u00a0membranes of some cells have extensions that have other functions, like flagella to help\u00a0sperm\u00a0move, or cilia to help keep our airways clear.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.4 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What are the general functions of the plasma membrane?<\/li>\n<li>Describe the phospholipid bilayer of the plasma membrane.<\/li>\n<li>Identify other molecules in the plasma membrane. State their functions.<\/li>\n<li>Why do some cells have plasma membrane extensions, like flagella and cilia?<\/li>\n<li>Explain why hydrophilic molecules cannot easily pass through the cell membrane. What type of molecule in the cell membrane might help hydrophilic molecules pass through it?<\/li>\n<li>Which part of a phospholipid molecule in the plasma membrane is made of fatty\u00a0acid\u00a0chains? Is this part hydrophobic or hydrophilic?<\/li>\n<li>The two layers of\u00a0phospholipids\u00a0in the plasma membrane are called a phospholipid ____________.<\/li>\n<li>\n<div id=\"h5p-38\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-38\" class=\"h5p-iframe\" data-content-id=\"38\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Plasma Membrane\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Steroid hormones can pass directly through cell membranes. Why do you think this is the case?<\/li>\n<li>Some antibiotics work by making holes in the plasma membrane of bacterial cells. How do you think this kills the cells?<\/li>\n<li>What is the name of the long, whip-like extensions of the plasma membrane that helps some single-celled organisms move?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.4 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=yAXnYcUjn5k&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Insights into cell membranes via dish detergent - Ethan Perlstein, TED-Ed, 2013.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=qBCVVszQQNs<\/p>\n<p style=\"text-align: center\">Inside the cell membrane, by The Amoeba Sisters, 2018.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.4.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Animal_Cell_Unannotated.svg\">Animal Cell Unannotated,<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kelvin13\">Kelvin Song<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\">CC0 1.0<\/a> (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) public domain dedication license.<\/p>\n<p><strong>Figure 4.4.2<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/aimeeknight\/5184668689\/\">Jello mold at the mexican bakery<\/a> photo by <a href=\"https:\/\/www.flickr.com\/photos\/aimeeknight\/\">Aim\u00e9e Knight<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/p>\n<p><strong>Figure 4.4.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:0302_Phospholipid_Bilayer.jpg\" rel=\"cc:attributionURL\">Phospholipid_Bilayer<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/3-1-the-cell-membrane\">OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0) license.<\/p>\n<p><strong>Figure 4.4.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:0303_Lipid_Bilayer_With_Various_Components.jpg\" rel=\"cc:attributionURL\">Lipid bilayer<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/3-1-the-cell-membrane\">OpenStax<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0) license.<\/p>\n<p><strong>Figure 4.4.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Spermatozoa-human-3140x.jpg\" rel=\"cc:attributionURL\">Spermatozoa-human-3140x<\/a> by No specific author on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:WP:PD\" href=\"https:\/\/en.wikipedia.org\/wiki\/WP:PD\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.4.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Bronchiolar_epithelium_3_-_SEM.jpg\">Cilia\/ Bronchiolar epithelium 3 - SEM<\/a> by Charles Daghlian on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:WP:PD\" href=\"https:\/\/en.wikipedia.org\/wiki\/WP:PD\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.4.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Adverse_effects_of_vaping_(raster).png\">Adverse effects of vaping (raster)<\/a> by <a title=\"User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:WP:PD\" href=\"https:\/\/en.wikipedia.org\/wiki\/WP:PD\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2018, February 27). Inside the cell membrane. YouTube. https:\/\/www.youtube.com\/watch?v=qBCVVszQQNs&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Betts, J.G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E.. Womble, M., DeSaix. P. (2013, April 25). Figure 3.3 Phospolipid Bilayer [digital image]. In <em>Anatomy and Physiology. OpenStax. <\/em>https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/3-1-the-cell-membrane<\/p>\n<p class=\"hanging-indent\"><span class=\"os-title-label\">Betts, J.G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E.. Womble, M., DeSaix. P. (2013, April 25). Figure\u00a0<\/span><span class=\"os-number\">3.4<\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"5458\" class=\"os-title\" data-type=\"title\">Cell Membrane<\/span><span class=\"os-divider\"> [digital image]. In <em>Anatomy and Physiology. OpenStax. <\/em>https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/3-1-the-cell-membrane<\/span><\/p>\n<p class=\"hanging-indent\">Ghosh, A., Coakley, R. C., Mascenik, T., Rowell, T. R., Davis, E. S., Rogers, K., Webster, M. J., Dang, H., Herring, L. E., Sassano, M. F., Livraghi-Butrico, A., Van Buren, S. K., Graves, L. M., Herman, M. A., Randell, S. H., Alexis, N. E., &amp; Tarran, R. (n.d.). Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome.\u00a0<i>American Journal of Respiratory and Critical \/Care Medicine<\/i>,\u00a0<i>198<\/i>(1), 67\u201376. https:\/\/doi-org.ezproxy.tru.ca\/10.1164\/rccm.201710-2033OC<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2013, February 26). Insights into cell membranes via dish detergent - Ethan Perlstein. YouTube. https:\/\/www.youtube.com\/watch?v=yAXnYcUjn5k&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2908\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2908\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 1024px\" class=\"wp-caption alignnone\"><img class=\"wp-image-250 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Ribosomal-Art.jpg\" alt=\"Image shows a large 3D work of art displayed at the Cold Spring Harbor Laboratory. It is a representation of ribosomes attached to a ribbon of metal meant to represent a strand of messenger RNA.\" width=\"1024\" height=\"768\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.1 \"Waltz of the Polypeptides\" sculpture by New York City-based artist Mara G. Haseltine, on display at Cold Spring Harbor Laboratory, NY.\u00a0 This artwork features multiple ribosomes creating polypeptides according to the directions on a piece of messenger RNA.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Ribosome\u00a0Review<\/h1>\n<\/div>\n<p>The 25-metre long sculpture shown in Figure 4.6.1 is a recognition of the beauty of one of the metabolic functions that takes place in the cells in your body.\u00a0 This artwork brings to life an important structure in living cells: the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">ribosome<\/a><\/strong>, the\u00a0cell structure\u00a0where\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2422\">proteins<\/a>\u00a0are synthesized. The slender silver strand is the messenger <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_519\">RNA<\/a>(mRNA)\u00a0bringing the code for a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2422\">protein<\/a> out into the cytoplasm.\u00a0 The purple and green structures are ribosomal subunits (which together form a single <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">ribosome<\/a>), which can \"read\" the code on the mRNA and direct the bonding of the correct sequence of amino acids to create a protein.\u00a0\u00a0All living\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cells<\/a>\u00a0\u2014 whether they are <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1572\">prokaryotic<\/a> or <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> \u2014 contain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">ribosomes<\/a>, but only eukaryotic cells also contain a\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a>\u00a0and several other types of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2083\">organelles<\/a>.<\/p>\n<div>\n<h1>What Are Organelles?<\/h1>\n<\/div>\n<p>An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2083\">organelle<\/a><\/strong>\u00a0is a structure within the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1963\">cytoplasm<\/a> of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cell<\/a> that is enclosed within a membrane and performs a specific job. Organelles are involved in many vital cell functions. Organelles in animal cells include the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a>,\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2383\">mitochondria<\/a>,\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2335\">endoplasmic reticulum<\/a>,\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1991\">Golgi apparatus<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2437\">vesicles<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2430\">vacuoles<\/a>. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">Ribosomes<\/a>\u00a0are not enclosed within a membrane, but they are still commonly referred to as organelles in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> cells.<\/p>\n<div>\n<h1>The Nucleus<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a><\/strong> is the largest organelle in a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> cell, and it's considered the cell\u2019s control center. It contains most of the cell\u2019s <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_277\">DNA<\/a>(which makes up chromosomes), and it is encoded with the genetic instructions for making <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2422\">proteins<\/a>. The function of the nucleus is to regulate gene expression, including controlling which proteins the cell makes. In addition to DNA, the nucleus contains a thick liquid called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2097\">nucleoplasm<\/a><\/strong>, which\u00a0is similar in\u00a0composition\u00a0to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2319\">cytosol<\/a> found in the cytoplasm outside the nucleus.\u00a0Most eukaryotic cells contain just a single nucleus, but some types of cells (such as red\u00a0blood\u00a0cells) contain no nucleus and a few other types of cells (such as muscle cells) contain multiple nuclei.<\/p>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 459px\" class=\"wp-caption alignright\"><img class=\" wp-image-251\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nucleus-1.png\" alt=\"This closeup of a cell nucleus shows that it is surrounded by a structure called the nuclear envelope, which contains tiny perforations, or pores. The nucleus also contains a dense center called the nucleolus.\" width=\"459\" height=\"425\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.2 This closeup of a cell nucleus shows that it is surrounded by a structure called the nuclear envelope, which contains tiny perforations, or pores. The nucleus also contains a dense center called the nucleolus.<\/em><\/figcaption><\/figure>\n<p>As you can see in the model pictured in Figure 4.6.2, the membrane enclosing the nucleus is called the <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2386\">nuclear envelope<\/a><\/strong>. This is actually a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm. Tiny holes called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2391\">nuclear pores<\/a><\/strong>\u00a0allow large molecules to pass through the nuclear envelope, with the help of special proteins. Large proteins and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_519\">RNA<\/a>\u00a0molecules must be able to pass through the nuclear envelope so proteins can be synthesized in the cytoplasm and the genetic material can be maintained inside the nucleus. The nucleolus shown in the model\u00a0below\u00a0is mainly involved in the assembly of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">ribosomes<\/a>. After being produced in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2397\">nucleolus<\/a>, ribosomes are exported to the cytoplasm, where they are involved in the synthesis of proteins.<\/p>\n<div>\n<h1>Mitochondria<\/h1>\n<\/div>\n<p>The\u00a0<strong>mitochondrion<\/strong>\u00a0(plural, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2383\">mitochondria<\/a>) is an organelle that makes\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a>\u00a0available to the cell. This is why\u00a0mitochondria\u00a0are sometimes referred to as the \"power plants of the cell.\" They use energy from\u00a0organic compounds\u00a0(such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1945\">glucose<\/a>) to make molecules of\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2072\">ATP<\/a> (adenosine triphosphate)<\/strong>, an energy-carrying molecule that is used almost universally inside cells for\u00a0energy.<\/p>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 459px\" class=\"wp-caption alignleft\"><img class=\" wp-image-252\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Mitochondrion_structure.svg_.png\" alt=\"Image shows a diagram of a mitochondrion. Labelled are the inner and outer membranes, the intermembrane space, the matrix, DNA and ribosomes.\" width=\"459\" height=\"265\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.3 Mitochondria contain their own DNA and ribosomes!<\/em><\/figcaption><\/figure>\n<p>Mitochondria (as in the Figure 4.6.3 diagram) have a complex structure including an inner and out membrane.\u00a0 In addition, mitochondria have their own DNA, ribosomes, and a version of cytoplasm, called matrix.\u00a0 Does this sound similar to the requirements to be considered a cell?\u00a0 That's because they are!<\/p>\n<p>Scientists think that mitochondria were once free-living organisms because they contain their own\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_277\">DNA<\/a>. They theorize that ancient\u00a0prokaryotes\u00a0infected (or were engulfed by) larger <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1572\">prokaryotic<\/a> cells, and the two organisms evolved a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2428\">symbiotic<\/a> relationship that benefited both of them. The larger cells provided the smaller prokaryotes with a place to live. In return, the larger cells got extra\u00a0energy\u00a0from the smaller prokaryotes. Eventually, the smaller prokaryotes became permanent guests of the larger cells, as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2083\">organelles<\/a>\u00a0inside them. This theory is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1986\">endosymbiotic theory<\/a>,<\/strong> and it is widely accepted by biologists today. (See the video <span style=\"text-align: initial;font-size: 1em\">in <a href=\"http:\/\/humanbiology.pressbooks.tru.ca\/chapter\/4-3-variation-in-cells\/\">section 4.3<\/a> to learn all about endosymbiotic theory.)<\/span><\/p>\n<div>\n<h1>Endoplasmic Reticulum<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2335\">endoplasmic reticulum<\/a><\/strong><strong>\u00a0(ER)<\/strong> is an organelle that helps make and transport <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2422\">proteins<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2205\">lipids<\/a>. There are two types of endoplasmic reticulum: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2145\">rough endoplasmic reticulum<\/a> (rER) and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2101\">smooth endoplasmic reticulum<\/a> (sER). Both types are shown in Figure 4.6.4.<\/p>\n<ul>\n<li>rER looks rough because it is studded with ribosomes. It provides a framework for the ribosomes, which make proteins. Bits of its membrane pinch off to form tiny sacs called vesicles, which carry proteins away from the ER.<\/li>\n<li>sER looks smooth because it does not have ribosomes. sER makes\u00a0lipids, stores substances, and plays other roles.<\/li>\n<\/ul>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 726px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-253\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Endomembrane_system_diagram_en.svg_.png\" alt=\"Image shows a diagram of the organelles included in the endomembrane system, inclduing: nuclear envelope, rough ER, smooth ER, golgi body, cell membrane, and vesicles.\" width=\"726\" height=\"577\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.4 The rough and smooth ER are part of a larger group of organelles termed \"the endomembrane system\". All of the organelles in this system are composed of plasma membrane.<\/em><\/figcaption><\/figure>\n<div>\n<p>The Figure 4.6.4 drawing includes the nucleus, rER, sER, and Golgi apparatus. From the drawing, you can see how all these organelles work together to make and transport proteins.<\/p>\n<\/div>\n<div>\n<h1>Golgi Apparatus<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1991\">Golgi apparatus<\/a><\/strong> (shown in the Figure 4.6.4 diagram) is a large organelle that processes proteins and prepares them for use both inside and outside the cell. You can see the Golgi apparatus in the figure above. The Golgi apparatus is something like a post office. It receives items (proteins from the ER), then packages and labels them before sending them on to their destinations (to different parts of the cell or to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2169\">cell membrane<\/a> for transport out of the cell). The Golgi apparatus is also involved in the transport of lipids around the cell.<\/p>\n<div>\n<h1>Vesicles and Vacuoles<\/h1>\n<\/div>\n<p>Both\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2437\">vesicles<\/a><\/strong>\u00a0and\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2430\">vacuoles<\/a>\u00a0<\/strong>are sac-like organelles made of phospholipid bilayer that store and transport materials in the cell. Vesicles are much smaller than vacuoles and have a variety of functions. The vesicles that pinch off from the membranes of the ER and Golgi apparatus store and transport <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2422\">protein<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2205\">lipid<\/a> molecules. You can see an example of this type of transport vesicle in the Figure 4.6.4. Some vesicles are used as chambers for biochemical reactions.<\/p>\n<p>There are some vesicles which are specialized to carry out specific functions.\u00a0 L<span style=\"font-size: 1em\">ysosomes, which use\u00a0enzymes\u00a0to break down foreign matter and dead cells, have a double membrane to make sure their contents don't leak into the rest of the cell.\u00a0 Peroxisomes are another type of specialized vesicle with the main function of breaking down fatty acids and some toxins.\u00a0<\/span><\/p>\n<div>\n<h1>Centrioles<\/h1>\n<\/div>\n<figure id=\"attachment_254\" aria-describedby=\"caption-attachment-254\" style=\"width: 442px\" class=\"wp-caption alignright\"><img class=\"wp-image-254 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Centrioles-1.png\" alt=\"Image shows a diagram of a centriole, made up of microtubules. There are nine bundles of microtubules arranged in a circle to form the tube-shaped centriole.\" width=\"442\" height=\"255\"><figcaption id=\"caption-attachment-254\" class=\"wp-caption-text\"><em>Figure 4.6.5 Centrioles are tiny cylinders near the nucleus, enlarged here to show their tubular structure.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2093\">Centrioles<\/a><\/strong>\u00a0are organelles involved in\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2186\">cell division<\/a>. The function of centrioles is to help organize the\u00a0<span style=\"font-size: 1em\"><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2166\">chromosomes<\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0before cell division occurs so that each daughter cell has the correct number of chromosomes after the cell divides. Centrioles are found only in animal cells, and are located near the nucleus. Each centriole is made mainly of a\u00a0<\/span>protein<span style=\"text-align: initial;font-size: 1em\">\u00a0named tubulin. The centriole is cylindrical in shape and consists of many microtubules, as shown in the model pictured\u00a0<\/span>in Figure 4.6.5<span style=\"text-align: initial;font-size: 1em\">.<\/span><\/p>\n<div>\n<figure id=\"attachment_255\" aria-describedby=\"caption-attachment-255\" style=\"width: 333px\" class=\"wp-caption alignleft\"><img class=\" wp-image-255\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Ribosome_shape.png\" alt=\"Image shows a diagram of a ribosome. It is made up of two sub-units, a smaller sub-unit shown in blue and a larger sub-unit shown in red.\" width=\"333\" height=\"314\"><figcaption id=\"caption-attachment-255\" class=\"wp-caption-text\"><em>Figure 4.6.6 Ribosomes are made up of two subunits, each consisting of protein and rRNA.<\/em><\/figcaption><\/figure>\n<h1>Ribosomes<\/h1>\n<\/div>\n<p>Ribosomes are small structures where proteins are made. Although they are not enclosed within a membrane, they are frequently considered organelles. Each <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">ribosome<\/a> is formed of two subunits, like the ones pictured at the beginning of this section (Figure 4.6.1) and in\u00a0 Figure 4.6.6. Both subunits consist of proteins and RNA. mRNA from the nucleus carries the genetic code, copied from DNA, which remains in the nucleus. At the ribosome, the genetic code in mRNA is used to assemble and join together amino acids to make proteins. Ribosomes can be found alone or in groups within the cytoplasm, as well as on the rER.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.6 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>An <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2083\">organelle<\/a> is a structure within the cytoplasm of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> cell that is enclosed within a membrane and performs a specific job. Although <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">ribosomes<\/a>\u00a0are not enclosed within a membrane, they are still commonly referred to as organelles in eukaryotic cells.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a> is the largest organelle in a eukaryotic cell, and it is considered to be the cell's control center. It controls\u00a0gene expression, including controlling which proteins the cell makes.<\/li>\n<li>The mitochondrion (plural, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2383\">mitochondria<\/a>) is an organelle that makes energy available to the cells. It is like the power plant of the cell. According to the widely accepted <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1986\">endosymbiotic theory<\/a>, mitochondria evolved from prokaryotic cells that were once free-living organisms that infected or were engulfed by larger prokaryotic cells.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2335\">endoplasmic reticulum<\/a> (ER) is an organelle that helps make and transport proteins and lipids. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2145\">Rough endoplasmic reticulum<\/a> (rER) is studded with ribosomes. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2101\">Smooth endoplasmic reticulum<\/a> (sER) has no ribosomes.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1991\">Golgi apparatus<\/a> is a large organelle that processes proteins and prepares them for use both inside and outside the cell. It is also involved in the transport of lipids around the cell.<\/li>\n<li>Both\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2437\">vesicles<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2430\">vacuoles<\/a>\u00a0are sac-like organelles that may be used to store and transport materials in the cell or as chambers for\u00a0biochemical reactions. Lysosomes and peroxisomes are special types of vesicles that break down foreign matter, dead cells, or poisons.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2093\">Centrioles<\/a> are organelles located near the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a> that help organize the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2166\">chromosomes<\/a>\u00a0before\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2186\">cell division<\/a>\u00a0so each daughter cell receives the correct number of chromosomes.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2074\">Ribosomes<\/a>\u00a0are small structures where proteins are made. They are found in both\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1572\">prokaryotic<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> cells. They may be found alone or in groups within the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1963\">cytoplasm<\/a> or on the rER.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.6 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is an\u00a0organelle?<\/li>\n<li>Describe the structure and function of the nucleus.<\/li>\n<li>Explain how the nucleus, ribosomes, rough endoplasmic reticulum, and Golgi apparatus work together to make and transport proteins.<\/li>\n<li>Why are mitochondria referred to as the \"power plants of the cell\"?<\/li>\n<li>What roles are played by\u00a0vesicles and vacuoles?<\/li>\n<li>Why\u00a0do all cells need ribosomes \u2014 even prokaryotic cells that lack a nucleus and other\u00a0cell organelles?<\/li>\n<li>Explain endosymbiotic theory as it relates to mitochondria. What is one piece of evidence that supports this theory?<\/li>\n<li>\n<div id=\"h5p-39\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-39\" class=\"h5p-iframe\" data-content-id=\"39\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Cell Organelles\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.6 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\" style=\"text-align: center\">\n<p>https:\/\/www.youtube.com\/watch?v=URUJD5NEXC8&amp;t=121s<\/p>\n<p>Biology: Cell Structure I Nucleus Medical Media, Nucleus Medical Media, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=Id2rZS59xSE&amp;feature=youtu.be<\/p>\n<p>David Bolinsky: Visualizing the wonder of a living cell, TED, 2007.<\/p>\n<\/div>\n<\/div>\n<h2>Attributes<\/h2>\n<p><strong>Figure 4.6.1\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/pedrik\/3534019319\" rel=\"cc:attributionURL\">Ribosomes at Work<\/a> by <a class=\"owner-name truncate\" title=\"Go to pedrik's photostream\" href=\"https:\/\/www.flickr.com\/photos\/pedrik\/\" data-track=\"attributionNameClick\">Pedrik<\/a> on <a href=\"https:\/\/www.flickr.com\/\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 4.6.2<\/strong><\/p>\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Cell_nucleus#\/media\/File:Blausen_0212_CellNucleus.png\" rel=\"cc:attributionURL\">Nucleus<\/a> <span style=\"text-align: initial;font-size: 1em\">by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 4.6.3\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Mitochondrion_structure.svg\" rel=\"cc:attributionURL\">Mitochondrion_structure.svg<\/a> by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kelvin13\">Kelvinsong<\/a>; modified by <a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Sowlos&amp;action=edit&amp;redlink=1\">Sowlos<\/a> on Wikimedia Commons is used and adapted by Christine Miller under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license.<\/p>\n<p><strong>Figure 4.6.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Endomembrane_system_diagram_en.svg\" rel=\"cc:attributionURL\">Endomembrane_system_diagram_en.svg<\/a> by Mariana Ruiz [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain <\/a>(https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figur<span style=\"font-size: 1em\">e 4.6.5<\/span><\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0214_Centrioles.png\" rel=\"cc:attributionURL\">Centrioles<\/a> <span style=\"text-align: initial;font-size: 1em\">by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.\u00a0<\/span><\/p>\n<p><strong>Figure 4.6.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Ribosome_shape.png\" rel=\"cc:attributionURL\">Ribosome_shape<\/a> by <a title=\"User:Vossman\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Vossman\">Vossman<\/a> on Wikimedia Commons is used and adapted by Christine Miller under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Nucleus - Medical gallery of Blausen Medical 2014. <i>WikiJournal of Medicine<\/i>\u00a01\u00a0(2).\u00a0DOI:10.15347\/wjm\/2014.010.\u00a0ISSN\u00a02002-4436. https:\/\/en.wikiversity.org\/wiki\/WikiJournal_of_Medicine\/Medical_gallery_of_Blausen_Medical_2014<\/p>\n<p class=\"hanging-indent\">Blausen.com staff (2014). Centrioles - Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.https:\/\/en.wikiversity.org\/wiki\/WikiJournal_of_Medicine\/Medical_gallery_of_Blausen_Medical_2014<\/p>\n<p class=\"hanging-indent\">Nucleus Medical Media. (2015, March 18). Biology: Cell structure I Nucleus Medical Media. YouTube. https:\/\/www.youtube.com\/watch?v=URUJD5NEXC8&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED. (2007, July 24). David Bolinsky: Visualizing the wonder of a living cell. YouTube. https:\/\/www.youtube.com\/watch?v=Id2rZS59xSE&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_5985\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_5985\"><div tabindex=\"-1\"><p>The body system which acts as a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. In humans, the major endocrine glands are the thyroid gland and the adrenal glands.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_5927\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_5927\"><div tabindex=\"-1\"><p>Refers to the body system consisting of the heart, blood vessels and the blood. Blood contains oxygen and other nutrients which your body needs to survive. The body takes these essential nutrients from the blood.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2911\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2911\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_267\" aria-describedby=\"caption-attachment-267\" style=\"width: 369px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-264\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Humvee-challenge-e1585588086447.jpg\" alt=\"Four soldiers pushing a Humvee. Their backs are against the vehicle and their faces show that they are pushing as hard as they can.\" width=\"369\" height=\"400\"><figcaption id=\"caption-attachment-267\" class=\"wp-caption-text\"><em>Figure 4.8.1 The Humvee challenge - Active transport.<\/em><\/figcaption><\/figure>\n<h1>Like Pushing a Humvee Uphill<\/h1>\n<p>You can tell by their faces that these airmen (Figure 4.8.1) are expending a lot of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a> trying to push this Humvee up a slope. The men are participating in a competition that tests their brute strength against that of other teams. The Humvee weighs about 13 thousand pounds (about 5,897 kilograms), so it takes every ounce of energy they can muster to move it uphill against the force of gravity. Transport of some substances across a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a> is a little like pushing a Humvee uphill \u2014 it can't be done without adding energy.<\/p>\n<div>\n<h1>What Is Active Transport?<\/h1>\n<\/div>\n<p>Some substances can pass into or out of a cell across the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a>\u00a0without any\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a>\u00a0required because they are moving from an area of higher\u00a0concentration\u00a0to an area of lower concentration. This type of transport is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2276\">passive transport<\/a><\/strong>. Other substances require energy to cross a\u00a0plasma membrane, often because they are moving from an area of lower\u00a0concentration\u00a0to an area of higher concentration, <em>against<\/em> the concentration gradient. This type of transport is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2256\">active transport<\/a><\/strong>. The energy for active transport comes from the energy-carrying molecule called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2072\">ATP<\/a> (adenosine triphosphate). Active transport may also require\u00a0proteins\u00a0called pumps,\u00a0which are embedded in the plasma membrane. Two types of active transport are\u00a0membrane pumps (such as the\u00a0sodium-potassium pump) and vesicle transport.<\/p>\n<div>\n<h2>The\u00a0Sodium-Potassium Pump<\/h2>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2287\">sodium-potassium pump<\/a><\/strong> is a mechanism of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2256\">active transport<\/a> that moves sodium ions out of the cell and potassium ions into the cells \u2014 in all the trillions of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cells<\/a> in the body! Both ions are moved from areas of lower to higher concentration, so energy is needed for this \"uphill\" process. The energy is provided by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2072\">ATP<\/a>. The sodium-potassium pump also requires <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2272\">carrier proteins<\/a>. Carrier proteins bind with specific ions or molecules, and in doing so, they change shape. As carrier proteins change shape, they carry the ions or molecules across the membrane. Figure 4.8.2 shows in greater detail how the sodium-potassium pump works, as well as the specific roles played by carrier proteins in this process.<\/p>\n<figure id=\"attachment_267\" aria-describedby=\"caption-attachment-267\" style=\"width: 819px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-265\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Sodium-Potassium-Pump-1.png\" alt=\"Image shows a diagram of a sodium potassium pump. The pump collects three sodium ions, and moves them out of the cell, against the concentration gradient by changing its shape. Then, the pump collects 2 potassium ions and by changing its shape, moves these two ions into the cell, also against the concentration gradient.\" width=\"819\" height=\"437\"><figcaption id=\"caption-attachment-267\" class=\"wp-caption-text\"><em>Figure 4.8.2 The sodium-potassium pump moves sodium ions (Na+) out of the cell and potassium ions (K+) into the cell. First, three sodium ions bind with a carrier protein in the cell membrane. The carrier protein then changes shape, powered by energy from ATP, and as it does, it pumps the three sodium ions out of the cell. At that point, two potassium ions bind to the carrier protein. The process is reversed, and the potassium ions are pumped into the cell.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"text-align: initial;font-size: 1em\">To appreciate the importance of the sodium-potassium pump, you need to know more about the roles of sodium and potassium in the body. Both are essential dietary minerals. You need to get them from the foods you eat. Both sodium and potassium are also electrolytes, which means they dissociate into ions (charged particles) in solution, allowing them to conduct electricity. Normal body functions require a very narrow range of concentrations of sodium and potassium ions in body fluids, both inside and outside of cells.<\/span><\/p>\n<\/div>\n<ul>\n<li>Sodium is the principal\u00a0ion\u00a0in the fluid outside of\u00a0cells. Normal sodium concentrations are about <em>ten times higher outside of cells<\/em> than inside of cells.\u00a0 To move sodium out of the cell is moving it against the concentration gradient<\/li>\n<li>Potassium is the principal\u00a0ion\u00a0in the fluid inside of cells. Normal potassium concentrations are about <em>30 times higher inside of cells<\/em> than outside of cells. To move potassium into the cell is moving it against the concentration gradient.<\/li>\n<\/ul>\n<p>These differences in concentration create an electrical and chemical gradient across the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2169\">cell membrane<\/a>, called the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2269\">membrane potential<\/a><\/strong>. Tightly controlling the membrane potential is critical for vital body functions, including the transmission of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2266\">nerve impulses<\/a> and contraction of muscles. A large percentage of the body's energy goes to maintaining this potential across the membranes of its trillions of cells with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2287\">sodium-potassium pump<\/a>.<\/p>\n<div>\n<h2>Vesicle Transport<\/h2>\n<\/div>\n<p>Some molecules, such as proteins, are too large to pass through the plasma membrane, regardless of their concentration inside and outside the cell. Very large molecules cross the plasma membrane with a different sort of help, called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2263\">vesicle transport<\/a><\/strong>. Vesicle transport requires energy input from the cell, so it is also a form of active transport. There are two types of vesicle transport: endocytosis and exocytosis. Both types are shown in Figure 4.8.3.<\/p>\n<figure id=\"attachment_267\" aria-describedby=\"caption-attachment-267\" style=\"width: 1024px\" class=\"wp-caption alignnone\"><img class=\"wp-image-266 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cytosis.jpg\" alt=\"Image shows a artist's rendition of a cell performing endo and exo cytosis. On the left side of the diagram, the cell is taking in large molecules through the plasma membrane by forming a vesicle around the particle. This is endocytosis. On the right side of the diagram, large molecules are exiting the cell by arriving in vesicles that fuse with the membrane to release their contents. This is exocytosis.\" width=\"1024\" height=\"576\"><figcaption id=\"caption-attachment-267\" class=\"wp-caption-text\"><em>Figure 4.8.3 Large molecules can enter and exit the cell with the help of vesicles. On the left side of the diagram you can see exocytosis, as large molecules exit the cell through the plasma membrane. On the right side of the diagram you can see endocytosis, as large molecules enter the cell through the plasma membrane, via vesicle formation.<\/em><\/figcaption><\/figure>\n<h3>Endocytosis<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2155\">Endocytosis<\/a><\/strong>\u00a0is a type of vesicle transport that moves a substance into the cell. The plasma membrane completely engulfs the substance, a vesicle pinches off from the membrane, and the vesicle carries the substance into the cell. When an entire cell or other\u00a0solid\u00a0particle is engulfed, the process is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1680\">phagocytosis<\/a>.<\/strong>\u00a0When fluid is engulfed, the process is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1681\">pinocytosis<\/a><\/strong>.<\/p>\n<h3>Exocytosis<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1682\">Exocytosis<\/a><\/strong>\u00a0is a type of vesicle transport that moves a substance out of the cell (exo-, like \"exit\"). A vesicle containing the substance moves through the cytoplasm to the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2169\">cell membrane<\/a>.\u00a0Because the vesicle\u00a0membrane\u00a0is a\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2137\">phospholipid bilayer<\/a>\u00a0like the plasma membrane, the vesicle membrane fuses with the\u00a0cell membrane, and the substance is released outside the cell.<\/p>\n<figure id=\"attachment_267\" aria-describedby=\"caption-attachment-267\" style=\"width: 703px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-267\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Endocytosis-and-Exocytosis.png\" alt=\"Image shows a diagram of both endocytosis and exocytosis. On the left side of the diagram, and large particle is being brought into the cell by creating a pocket of plasma membrane around the particle. This pocket deepens and eventually pinches off from the rest of the membrane, forming a vesicle containing the particle. This process is called endocytosis. On the right side of the diagram, a vesicle containing substances for export out of the cell are contained in a vesicle. The vesicle travels to the cell membrane and the vesicular membrane fuses with the cell membrane, releasing the contents of the vesicle outside of the cell.\" width=\"703\" height=\"607\"><figcaption id=\"caption-attachment-267\" class=\"wp-caption-text\"><em>Figure 4.8.4 Endocytosis brings substances into the cell via vesicle formation. Exocytosis allows substances to exit the cell by merging a transport vesicle with the cell membrane.<\/em><\/figcaption><\/figure>\n<div>\n<p><span style=\"font-size: 1.602em;font-weight: bold\">Feature: My Human Body<\/span><\/p>\n<\/div>\n<p>Maintaining the proper balance of sodium and potassium in body fluids by active transport is necessary for life itself, so it's no surprise that getting the right balance of sodium and potassium in the diet is important for good health. Imbalances may increase the risk of <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/high-blood-pressure\/symptoms-causes\/syc-20373410\">high\u00a0blood pressure<\/a>,\u00a0<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/heart-disease\/symptoms-causes\/syc-20353118\">heart\u00a0disease<\/a>,\u00a0<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/diabetes\/symptoms-causes\/syc-20371444\">diabetes<\/a>, and other disorders.<\/p>\n<p>If you are like the majority of North Americans, sodium and potassium are out of balance in your diet. You are likely to consume too much sodium and too little potassium. Follow these guidelines to help ensure that these minerals are balanced in the foods you eat:<\/p>\n<ul>\n<li>Total sodium intake should be less than 2,300 mg\/day. Most salt in the diet is found in processed foods, or added with a salt shaker. Stop adding salt and start checking food labels for sodium content. Foods considered low in sodium have less than 140 mg\/serving (or 5 per cent daily value).<\/li>\n<li>Total potassium intake should be 4,700 mg\/day. It's easy to add potassium to the diet by choosing the right foods \u2014 and there are plenty of choices! Most fruits and vegetables are high in potassium. Potatoes, bananas, oranges, apricots, plums, leafy greens, tomatoes, lima beans, and avocado are especially good sources. Other foods with substantial amounts of potassium are fish, meat, poultry, and whole grains. The collage below shows some of these potassium-rich foods.<\/li>\n<\/ul>\n<p style=\"text-align: center\">\n<div id=\"h5p-41\">\n<div class=\"h5p-content\" data-content-id=\"41\"><\/div>\n<\/div>\n<p><em>Figure 4.8.5 Potassium power!\u00a0<\/em><\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.8 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2256\">Active transport<\/a> requires <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a> to move substances across a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1996\">plasma membrane<\/a>, often because the substances are moving from an area of lower concentration to an area of higher concentration, or because of their large size. Two types of active transport are membrane pumps (such as the sodium-potassium pump) and vesicle transport.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2287\">sodium-potassium pump<\/a> is a mechanism of active transport that moves sodium ions out of the cell and potassium ions into the cell against a concentration gradient, in order to maintain the proper concentrations of ions, both inside and outside the cell, and to thereby control membrane potential.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2263\">Vesicle transport<\/a> is a type of active transport that uses <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2437\">vesicles<\/a>\u00a0to move large molecules into or out of cells.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.8 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Define active transport.<\/li>\n<li>\n<div id=\"h5p-42\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-42\" class=\"h5p-iframe\" data-content-id=\"42\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Active Transport\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What is the sodium-potassium pump? Why is it so important?<\/li>\n<li>The drawing below shows the fluid inside and outside of a cell. The dots represent molecules of a substance needed by the cell. Explain which type of transport \u2014 active or passive \u2014 is needed to move the molecules into the cell.<br \/>\n<figure id=\"attachment_268\" aria-describedby=\"caption-attachment-268\" style=\"width: 317px\" class=\"wp-caption alignnone\"><img class=\"wp-image-268\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Active-Transport.png\" alt=\"Image shows a cell with higher concentrations of a substance on the inside of the cell than on the outside of the cell. The cell is in a hypotonic solution\" width=\"317\" height=\"282\"><figcaption id=\"caption-attachment-268\" class=\"wp-caption-text\">Figure 4.8.6 Use this image to answer question #4<\/figcaption><\/figure>\n<\/li>\n<li>What are the similarities and differences between phagocytosis and pinocytosis?<\/li>\n<li>What is the functional significance of the shape change of the carrier protein in the sodium-potassium pump after the sodium ions bind?<\/li>\n<li>A potentially deadly poison derived from plants called <a href=\"https:\/\/en.wikipedia.org\/wiki\/Ouabain\">ouabain<\/a> blocks the sodium-potassium pump and prevents it from working. What do you think this does to the sodium and potassium balance in cells? Explain your answer.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.8 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=Z_mXDvZQ6dU&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Neutrophil Phagocytosis - White Blood Cell Eats Staphylococcus Aureus Bacteria,<br \/>\nImmiflexImmuneSystem, 2013.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=Ptmlvtei8hw<\/p>\n<p style=\"text-align: center\">Cell Transport, The Amoeba Sisters, 2016.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.8.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Defenders_compete_in_Aces_Cop_Combat_Challenge_150605-F-GF295-011.jpg\" rel=\"cc:attributionURL\">Humvee challenge<\/a> by Airman 1st Class Collin Schmidt on Wikimedia Commons is released into the <a class=\"extiw\" title=\"en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.8.2<\/strong><\/p>\n<p>Sodium Potassium Pump by Christine Miller is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">CC BY 4.0<\/a>\u00a0 <span style=\"text-align: initial;font-size: 1em\">(<\/span><span style=\"text-align: initial;font-size: 1em\">https:\/\/creativecommons.org\/licenses\/by\/4.0\/) license.<\/span><\/p>\n<p><strong>Figure 4.8.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cytosis.jpg\" rel=\"cc:attributionURL\">Cytosis<\/a> by <a class=\"new mw-userlink\" title=\"User:Manu5 (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Manu5&amp;action=edit&amp;redlink=1\">Manu5<\/a>\u00a0on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 4.8.4\u00a0<\/strong><\/p>\n<p>Endocytosis and Exocytosis by Christine Miller is used under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">CC BY 4.0<\/a>\u00a0 <span style=\"text-align: initial;font-size: 1em\">(<\/span><span style=\"text-align: initial;font-size: 1em\">https:\/\/creativecommons.org\/licenses\/by\/4.0\/) license. <\/span><\/p>\n<p><strong>Figure 4.8.5<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cantaloupes.jpg\">Canteloupes. Image Number K7355-11<\/a> by <a href=\"https:\/\/www.ars.usda.gov\/oc\/images\/photos\/k7388-11\/\">Scott Bauer\/ USDA<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/4TY1uOJ5LG4\">Spinach<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@chiapppa\">chiara conti<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash license<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Eleven_long_purple_eggplants.jpg\">Eleven long purple eggplants<\/a> by <a title=\"User:JVRKPRASAD\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:JVRKPRASAD\">JVRKPRASAD<\/a> on Wikimedia commons is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY-SA 4.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/www.pexels.com\/photo\/2286779\">Bananas<\/a> by <a href=\"https:\/\/www.pexels.com\/@victorino\">Marco Antonio Victorino<\/a> on <a href=\"http:\/\/pexels.com\">Pexels<\/a> is used under the <a href=\"https:\/\/www.pexels.com\/license\/\">Pexels license<\/a> (https:\/\/www.pexels.com\/license\/).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/pmtoSHrzcM8\">Potato picking<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@trancisky\">Nic D<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash license<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/unsplash.com\/photos\/YV593oyMKmo\">Maldives<\/a> by <a class=\"_3XzpS _1ByhS _4kjHg _1O9Y0 _3l__V _1CBrG xLon9\" href=\"https:\/\/unsplash.com\/@sebaspenalambarri\">Sebastian Pena Lambarri<\/a> on <a href=\"http:\/\/unsplash.com\">Unsplash<\/a> is used under the <a href=\"https:\/\/unsplash.com\/license\">Unsplash license<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<\/ul>\n<p><strong>Figure 4.8.6<\/strong><\/p>\n<p>Active Transport by Christine Miller is released into the <a class=\"extiw\" title=\"en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2016, June 24). Cell transport [digital image]. YouTube. https:\/\/www.youtube.com\/watch?v=Ptmlvtei8hw&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">ImmiflexImmuneSystem. (2013). Neutrophil phagocytosis - White blood cell eats staphylococcus aureus bacteria. YouTube. https:\/\/www.youtube.com\/watch?v=Z_mXDvZQ6dU<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Diabetes [online]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/diabetes\/symptoms-causes\/syc-20371444<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). High blood pressure (hypertension) [online]. MayoClinic.org. https:\/\/www.mayoclinic.org\/diseases-conditions\/high-blood-pressure\/symptoms-causes\/syc-20373410<\/p>\n<p class=\"hanging-indent\">Mayo Clinic Staff. (n.d.). Heart disease [online]. MayoClinic.org.\u00a0 https:\/\/www.mayoclinic.org\/diseases-conditions\/heart-disease\/symptoms-causes\/syc-20353118<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 19). Ouabain. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Ouabain&amp;oldid=963440756<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2912\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2912\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<h1>Mush!<\/h1>\n<figure id=\"attachment_277\" aria-describedby=\"caption-attachment-277\" style=\"width: 414px\" class=\"wp-caption alignright\"><img class=\" wp-image-271\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Dogsled.jpg\" alt=\"Image shows a photo of a sled carrying two men being pulled by 8 huskies.\" width=\"414\" height=\"310\"><figcaption id=\"caption-attachment-277\" class=\"wp-caption-text\"><em>Figure 4.9.1 All living things require energy to maintain homeostasis. These sled dogs use energy as they pull the sled.<\/em><\/figcaption><\/figure>\n<p>These beautiful sled dogs are a metabolic marvel. While running up to 160 kilometres (about 99 miles) a day, they will each consume and burn about 12 thousand calories \u2014 about 240 calories per pound per day, which is the equivalent of about 24 Big Macs! A human endurance athlete, in contrast, typically burns only about 100 calories per pound (0.45 kg) each day. Scientists are intrigued by the amazing metabolism of sled dogs, although they still haven't determined how they use up so much energy. But one thing is certain: all living things need energy for everything they do, whether it's running a race or blinking an eye. In fact, every cell of your body constantly needs energy just to carry out basic life processes. You probably know that you get energy from the food you eat, but where does food come from? How does it come to contain energy? And how do your cells get the energy from food?<\/p>\n<div>\n<h1>What Is Energy?<\/h1>\n<\/div>\n<p>In the scientific world,\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a><\/strong>\u00a0is defined as the ability to do work. You can often see energy at work in living things\u00a0\u2014\u00a0a bird flies through the air, a firefly glows in the dark, a dog wags its tail. These are obvious ways that living things use energy, but living things constantly use energy in less obvious ways, as well.<\/p>\n<div>\n<h1>Why Living Things Need Energy<\/h1>\n<\/div>\n<p>Inside every <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cell<\/a> of all living things, energy is needed to carry out life processes. Energy is required to break down and build up molecules, and to transport many molecules across\u00a0plasma\u00a0membranes. All of life\u2019s work needs energy. A lot of energy is also simply lost to\u00a0the environment\u00a0as\u00a0heat. The story of life is a story of\u00a0energy flow\u00a0\u2014 its capture, its change of form, its use for work, and its loss as heat. Energy (unlike matter) cannot be recycled, so organisms require a constant input of energy. Life runs on chemical energy. Where do living organisms get this chemical energy?<\/p>\n<div>\n<h1>How Organisms Get Energy<\/h1>\n<\/div>\n<p>The chemical energy that organisms need comes from food.\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1948\">Food<\/a>\u00a0<\/strong>consists of organic molecules that store energy in their\u00a0chemical bonds. In terms of obtaining food for energy, there are two types of organisms:\u00a0autotrophs and heterotrophs.<\/p>\n<h2>Autotrophs<\/h2>\n<p><strong>Autotrophs<\/strong>\u00a0are organisms that\u00a0capture <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a> from nonliving sources and transfer that energy into the living part of the ecosystem. They are also able to make their own food. Most autotrophs use the energy in sunlight to make food in the process of\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2245\">photosynthesis<\/a><\/strong>. Only certain organisms \u2014 such as plants, algae, and some bacteria \u2014 can make food through photosynthesis. Some photosynthetic organisms are shown in Figure 4.9.2.<\/p>\n<table style=\"border-collapse: collapse;width: 100%\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%\"><img class=\"aligncenter wp-image-1712\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Plant-e1564025979402-scaled.jpg\" alt=\"Image shows a photo of a leafy plant\" width=\"200\" height=\"124\"><\/td>\n<td style=\"width: 33.3333%\"><img class=\"aligncenter wp-image-273\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Green-Algae.jpg\" alt=\"Image shows a photograph of green algae living on the ocean floor\" width=\"200\" height=\"132\"><\/td>\n<td style=\"width: 33.3333%\"><img class=\"aligncenter wp-image-274\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cyanobacteria.jpg\" alt=\"\" width=\"200\" height=\"141\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%\"><\/td>\n<td style=\"width: 33.3333%\"><em><span style=\"text-align: initial;font-size: 1em\">Figure 4.9.2 Photosynthetic autotrophs, which make food using the energy in sunlight, include plants (left), algae (middle), and<\/span><span style=\"font-size: 1em;text-align: initial\">\u00a0certain bacteria (right).<\/span><\/em><\/td>\n<td style=\"width: 33.3333%\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Autotrophs\u00a0are also called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1713\">producers<\/a><\/strong>. They produce food not only for themselves, but for all other living things (known as consumers), as well. This is why autotrophs form the basis of food chains, such as the food chain shown In Figure 4.9.3.<\/p>\n<figure id=\"attachment_277\" aria-describedby=\"caption-attachment-277\" style=\"width: 1500px\" class=\"wp-caption alignleft\"><img class=\"wp-image-275 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Biomass_Pyramid.png\" alt=\"Diagram shows two food pyramids, each with trophic levels labelled.\" width=\"1500\" height=\"553\"><figcaption id=\"caption-attachment-277\" class=\"wp-caption-text\"><em>Figure 4.9.3 Food chains: Aquatic and terrestrial ecosystems.<\/em><\/figcaption><\/figure>\n<div>\n<p>A food chain shows how energy and matter flow from producers to consumers. Matter is recycled, but energy must keep flowing into the system. Where does this energy come from?<\/p>\n<\/div>\n<p>Watch the video \"The simple story of photosynthesis and food - Amanda Ooten\" from TED-Ed to learn more about photosynthesis:<\/p>\n<p>https:\/\/www.youtube.com\/watch?time_continue=39&amp;v=eo5XndJaz-Y<\/p>\n<p style=\"text-align: center\">The simple story of photosynthesis and food - Amanda Ooten, TED-Ed, 2013.<\/p>\n<h2>Heterotrophs<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1716\">Heterotrophs<\/a><\/strong>\u00a0are living things that cannot make their own food. Instead, they get their food by consuming other organisms, which is why they are also called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2095\">consumers<\/a><\/strong>. They may consume autotrophs or other <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1716\">heterotrophs<\/a>. Heterotrophs include all animals and fungi, as well as many single-celled organisms. In Figure 4.9.3, all of the organisms are consumers except for the grasses and phytoplankton. What do you think would happen to consumers if all producers were to vanish from Earth?<\/p>\n<div>\n<h1>Energy Molecules: Glucose and ATP<\/h1>\n<\/div>\n<p>Organisms mainly use two types of molecules for chemical energy: glucose and ATP. Both molecules are used as fuels throughout the living world. Both molecules are also key players in the process of\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2245\">photosynthesis<\/a>.<\/p>\n<h2>Glucose<\/h2>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1945\">Glucose<\/a><\/strong>\u00a0is a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2394\">simple\u00a0carbohydrate<\/a>\u00a0with the\u00a0chemical formula\u00a0C<sub>6<\/sub>H<sub>12<\/sub>O<sub>6<\/sub>. It stores chemical <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a> in a concentrated, stable form. In your body, glucose is the form of energy that is carried in your blood and taken up by each of your trillions of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cells<\/a>. Glucose is the end product of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2245\">photosynthesis<\/a>, and it is the nearly universal food for life.\u00a0 In Figure 4.9.4, you can see how photosynthesis stores energy from the sun in the glucose molecule and then how cellular respiration breaks the bonds in glucose to retrieve the energy.<\/p>\n<figure id=\"attachment_277\" aria-describedby=\"caption-attachment-277\" style=\"width: 623px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-276\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Photosynthesis-and-respiration.png\" alt=\"Image shows the formula for photosynthesis: Carbon dioxide and water are converted to glucose and oxygen, which is an endothermic reaction drawing its energy from the sun. Cellular respiration carries out the opposite reaction, breaking down glucose in the presence of oxygen to produce carbon dioxide and water, and releasing the energy previously stored in the glucose molecule, which is an exothermic reaction.\" width=\"623\" height=\"416\"><figcaption id=\"caption-attachment-277\" class=\"wp-caption-text\"><em>Figure 4.9.4 Energy transfer in photosynthesis and cellular respiration.<\/em><\/figcaption><\/figure>\n<h2>ATP<\/h2>\n<p><span style=\"font-size: 1em\">If you remember from <a href=\"http:\/\/humanbiology.pressbooks.tru.ca\/chapter\/3-7-nucleic-acids\/\">section 3.7 Nucleic Acids<\/a>,<\/span><span style=\"font-size: 1em\">\u00a0<\/span><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2072\">ATP<\/a><\/strong> (adenosine triphosphate) is the energy-carrying molecule that cells use to power most cellular processes (nerve impulse conduction, protein synthesis and active transport are good examples of cell processes that rely on ATP as their energy source).\u00a0 ATP is made during the first half of photosynthesis and then used for energy during the second half of photosynthesis, when glucose is made. ATP releases energy when it gives up one of its three phosphate groups (Pi) and changes to ADP (adenosine diphosphate, which has two phosphate groups), as shown in Figure 4.9.5. Thus, the breakdown of ATP into ADP + Pi is a catabolic reaction that releases energy (exothermic). ATP is made from the combination of ADP and Pi, an anabolic reaction that takes in energy (endothermic).<\/p>\n<figure id=\"attachment_277\" aria-describedby=\"caption-attachment-277\" style=\"width: 247px\" class=\"wp-caption alignright\"><img class=\"size-medium wp-image-183\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/ATP-for-energy-247x300.png\" alt=\"Image shows a diagram of the ATP molecule which consists of adenosine, ribose, and three phosphate groups. When the bond between the second and third phosphate group is broken, energy previously stored in the chemical bonds is released.\" width=\"247\" height=\"300\"><figcaption id=\"caption-attachment-277\" class=\"wp-caption-text\">Figure 4.9.5 ATP (adenosine TRI phosphate) can be converted to ADP (adensosine DI phosphate) to release the energy stored in the chemical bonds between the second and third phosphate group.<\/figcaption><\/figure>\n<h2>Why Organisms Need Both Glucose and ATP<\/h2>\n<p>Why do living things need glucose if ATP is the molecule that cells use for energy? Why don\u2019t autotrophs just make ATP and be done with it? The answer is in the \u201cpackaging.\u201d A molecule of glucose contains more chemical energy in a smaller \u201cpackage\u201d than a molecule of ATP. Glucose is also more stable than ATP. Therefore, glucose is better for storing and transporting energy. Glucose, however, is too powerful for cells to use. ATP, on the other hand, contains just the right amount of energy to power life processes within cells. For these reasons, both glucose and ATP are needed by living things.<\/p>\n<div>\n<h1>How Energy Flows Through Living Things<\/h1>\n<\/div>\n<p>The flow of energy through living organisms begins with photosynthesis. This process stores energy from sunlight in the\u00a0chemical bonds\u00a0of glucose. By breaking the chemical bonds in glucose, cells release the stored energy and make the ATP they need. The process in which glucose is broken down and ATP is made is called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2305\">cellular respiration<\/a><\/strong>.<\/p>\n<p>Photosynthesis and cellular respiration are like two sides of the same coin. This is apparent in Figure 4.9.6. The products of one process are the reactants of the other. Together, the two processes store and release energy in living organisms. The two processes also work together to recycle oxygen in the Earth\u2019s atmosphere.<\/p>\n<figure id=\"attachment_277\" aria-describedby=\"caption-attachment-277\" style=\"width: 565px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-277 \" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Photo-synthesis-vs-respiration.jpg\" alt=\"Image shows a diagram of photosynthesis taking place in chloroplasts and converting carbon dioxide and water into glucose and oxygen. The image also shows how the products of photosynthesis can be transferred into the mitochondria to undergo cellular respiration, converting them back into carbon dioxide and water, and in doing so, releasing the stored energy in the glucose molecule.\" width=\"565\" height=\"600\"><figcaption id=\"caption-attachment-277\" class=\"wp-caption-text\"><em>Figure 4.9.6 This diagram compares and contrasts photosynthesis and cellular respiration. It also shows how the two processes are related.<\/em><\/figcaption><\/figure>\n<div>\n<p>&nbsp;<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.9 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Energy is the ability to do work.\u00a0It\u00a0is needed by all living things and every living <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2223\">cell<\/a> to carry out life processes, such as breaking down and building up molecules, and transporting many molecules across cell membranes.<\/li>\n<li>The form of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a> that living things need for these processes is chemical energy, and it comes from food. Food consists of organic molecules that store energy in their\u00a0chemical bonds.<\/li>\n<li>Autotrophs\u00a0make their own food.\u00a0Plants, for example, make food by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2245\">photosynthesis<\/a>. Autotrophs are also called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1713\">producers<\/a>.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1716\">Heterotrophs<\/a>s obtain food by eating other organisms. Heterotrophs are also\u00a0known as\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2095\">consumers<\/a>.<\/li>\n<li>Organisms mainly use the molecules <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1945\">glucose<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2072\">ATP<\/a> for <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2340\">energy<\/a>. Glucose is a compact, stable form of energy that is carried in the\u00a0blood and taken up by cells. ATP contains less energy and is used to power cell processes.<\/li>\n<li>The flow of energy through living things begins with photosynthesis, which creates glucose. In a process called\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2305\">cellular respiration<\/a>,\u00a0organisms' cells\u00a0break down glucose and make the ATP they need.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.9 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Define energy.<\/li>\n<li>Why do living things need energy?<\/li>\n<li>\n<div id=\"h5p-43\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-43\" class=\"h5p-iframe\" data-content-id=\"43\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Energy Needs of Living Things\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Compare and contrast the two basic ways that organisms get\u00a0energy.<\/li>\n<li>Describe the roles and relationships of the energy molecules glucose and ATP.<\/li>\n<li>Summarize how energy flows through living things.<\/li>\n<li>Why does the transformation of ATP to ADP release energy?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.9 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=eDalQv7d2cs<\/p>\n<p style=\"text-align: center\">Learn Biology: Autotrophs vs. Heterotrophs, Mahalodotcom, 2011.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=0glkXIj1DgE&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Energy Transfer in Trophic Levels, Teacher's Pet, 2015.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<div id=\"content\" class=\"site-content\">\n<section class=\"standard post-596 chapter type-chapter status-publish hentry focusable\" data-type=\"chapter\">\n<div class=\"media-atttributions\">\n<p><strong style=\"text-align: initial;color: #333333;font-size: 1em\">Figure 4.9.1<\/strong><br \/>\n<a href=\"http:\/\/www.publicdomainfiles.com\/show_file.php?id=13497693619203\" rel=\"cc:attributionURL\">Three Airmen participate in dog-sled expedition<\/a> by <a href=\"https:\/\/www.af.mil\/News\/Photos\/\">U.S. Air Force<\/a> photo by Tech. Sgt. Dan Rea is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.9.2<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/unsplash.com\/photos\/bBiuSdck8tU\" rel=\"cc:attributionURL\">Plant [photo]<\/a> by\u00a0<a href=\"https:\/\/unsplash.com\/@renran\" rel=\"dc:creator\">Ren Ran<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/kewl\/5312016650\" rel=\"cc:attributionURL\">Green Algae<\/a>\u00a0by\u00a0<a href=\"https:\/\/www.flickr.com\/photos\/kewl\/\" rel=\"dc:creator\">Tristan Schmurr<\/a> on <a href=\"https:\/\/www.flickr.com\/\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0\/) license.<\/li>\n<li><a href=\"https:\/\/www.flickr.com\/photos\/argonne\/5909383026\" rel=\"cc:attributionURL\">Cyanobacteria<\/a>\u00a0by <a href=\"https:\/\/www.flickr.com\/photos\/argonne\/\">Argon National Laboratory<\/a> on <a href=\"https:\/\/www.flickr.com\/\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\">CC BY-NC-SA 2.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/li>\n<\/ul>\n<p><strong>Figure 4.9.3<\/strong><\/p>\n<p><a href=\"https:\/\/en.m.wikipedia.org\/wiki\/File:Biomass_Pyramid.svg\" rel=\"cc:attributionURL\">Biomass_Pyramid<\/a> by <a class=\"new\" title=\"User:Swiggity.Swag.YOLO.Bro (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Swiggity.Swag.YOLO.Bro&amp;action=edit&amp;redlink=1\">Swiggity.Swag.YOLO.Bro<\/a> on Wikipedia is used and adapted by Christine Miller under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.en) license.<\/p>\n<p><strong>Figure 4.9.4<\/strong><\/p>\n<p>Photosynthesis and respiration by Christine Miller is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">CC BY 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/4.0\/) license.<\/p>\n<p><strong>Figure 4.9.5<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/CK-12-College-Human-Biology\/section\/4.9\/\" rel=\"cc:attributionURL\">Photo synthesis and cellular respiration<\/a> by Lady of Hats\/ CK-12 Foundation is used under a <a class=\" dxtrack-user-action Link__LinkItem-sc-15rka1e-0 kxTgHz\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-dx-desc=\"course_modality_image_attribution_license\"><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\">CC BY-NC 3.0<\/span><\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.<\/p>\n<div><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a><\/div>\n<div>\n<div>Licensed under\u00a0<a href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a>\u00a0\u2022\u00a0<a href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a>\u00a0\u2022\u00a0<a href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">LadyofHats\/CK-12 Foundation. (2016, August 15). Figure 5: Photosynthesis and cellular respiration [digital image]. In Brainard, J., and Henderson, R., <em>CK-12's College Human Biology FlexBook\u00ae <\/em>(Section 4.9)<em>. <\/em>CK-12 Foundation. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/4.9\/<\/p>\n<p class=\"hanging-indent\">Mahalodotcom. (2011, January 14). Learn biology: Autotrophs vs. heterotrophs. YouTube. https:\/\/www.youtube.com\/watch?v=eDalQv7d2cs<\/p>\n<p class=\"hanging-indent\">Teacher's Pet. (2015, March 23). Energy transfer in trophic levels. YouTube. https:\/\/www.youtube.com\/watch?v=0glkXIj1DgE&amp;feature=emb_logo<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2013, March 5). The simple story of photosynthesis and food - Amanda Ooten. YouTube. https:\/\/www.youtube.com\/watch?v=eo5XndJaz-Y&amp;feature=youtu.be<\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_5969\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_5969\"><div tabindex=\"-1\"><p>A body system including a series of hollow organs joined in a long, twisting tube from the mouth to the anus. The hollow organs that make up the GI tract are the mouth, esophagus, stomach, small intestine, large intestine, and anus. The liver, pancreas, and gallbladder are the solid organs of the digestive system.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2914\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2914\"><div tabindex=\"-1\"><p><span style=\"font-size: 1em\">Created by:\u00a0CK-12\/Adapted by Christine Miller<\/span><\/p>\n<figure id=\"attachment_293\" aria-describedby=\"caption-attachment-293\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-290\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Sprinters-e1564874496956.jpg\" alt=\"Image shows a photo of women in a short distance running race on a track.\" width=\"400\" height=\"391\"><figcaption id=\"caption-attachment-293\" class=\"wp-caption-text\"><em>Figure 4.11.1 Sprinters racing on a track.\u00a0<\/em><\/figcaption><\/figure>\n<h1>Fast and Furious<\/h1>\n<p>These sprinters' muscles\u00a0will need a lot of\u00a0energy\u00a0to complete this short race, because they will be running at top\u00a0speed. The action won't last long, but it will be very intense. The energy each sprinter needs can't be provided quickly enough by aerobic\u00a0cellular respiration. Instead,\u00a0their muscle\u00a0cells must use a\u00a0different process to power their activity.<\/p>\n<div>\n<h1>Making ATP Without Oxygen<\/h1>\n<\/div>\n<p>Living things'\u00a0cells\u00a0power their activities with the energy-carrying molecule <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2072\">ATP<\/a> (adenosine triphosphate). The\u00a0cells\u00a0of most living things make ATP from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1945\">glucose<\/a> in the process of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2305\">cellular respiration<\/a>. This process occurs in three stages:\u00a0glycolysis, the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1805\">Krebs cycle<\/a>, and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1974\">electron transport<\/a>. The latter two stages require oxygen, making cellular respiration an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1796\">aerobic<\/a> process. When oxygen is not available in cells, the ETS quickly shuts down.\u00a0 Luckily, there are also ways of making ATP from glucose which are\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1826\">anaerobic<\/a>,<\/strong>\u00a0which means that they do not require oxygen. These processes are referred to collectively as\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2163\">anaerobic respiration<\/a><\/strong>.<\/p>\n<div>\n<h1>Fermentation<\/h1>\n<\/div>\n<p>Ome important way of making ATP without oxygen is\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2670\">fermentation<\/a>.\u00a0<\/strong>Fermentation starts with\u00a0glycolysis, which does not require oxygen, but it does not involve the latter two stages of aerobic cellular respiration (the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1805\">Krebs cycle<\/a>\u00a0and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1974\">electron\u00a0transport<\/a>).\u00a0There are two types of fermentation:\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2506\">alcoholic fermentation<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1830\">lactic\u00a0acid\u00a0fermentation<\/a>. We make use of both types of fermentation\u00a0using other\u00a0organisms, but only lactic\u00a0acid\u00a0fermentation actually takes place inside the\u00a0human body.<\/p>\n<h2>Alcoholic Fermentation<\/h2>\n<figure id=\"attachment_293\" aria-describedby=\"caption-attachment-293\" style=\"width: 443px\" class=\"wp-caption alignleft\"><img class=\" wp-image-291\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/alcoholic-fermentation.jpg\" alt=\"\" width=\"443\" height=\"164\"><figcaption id=\"caption-attachment-293\" class=\"wp-caption-text\"><em>Figure 4.11.2 In alcoholic fermentation, pyruvate is converted to ethanol and carbon dioxide.\u00a0 During this process, NAD+ is formed, which allows glycolysis to continue making ATP.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2506\">Alcoholic fermentation<\/a>\u00a0<\/strong>is carried out by single-celled\u00a0fungi\u00a0(called yeasts), as well as some\u00a0bacteria. We use alcoholic fermentation in these organisms to make <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1832\">biofuels<\/a>, bread, and wine. The <a href=\"https:\/\/en.wikipedia.org\/wiki\/Ethanol_fuel\">biofuel ethanol<\/a> (a type of alcohol), for example, is produced by alcoholic fermentation of the glucose in corn or other plants. The process by which this happens is summarized in the diagram\u00a0below. The two pyruvic acid molecules shown in the diagram come from the splitting of glucose in the first stage of the process (glycolysis). ATP is\u00a0also made during\u00a0glycolysis. Two molecules of ATP are produced from each molecule of glucose.<\/p>\n<figure id=\"attachment_293\" aria-describedby=\"caption-attachment-293\" style=\"width: 430px\" class=\"wp-caption alignright\"><img class=\"wp-image-1833\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Bread-e1564876273763.jpg\" alt=\"Image shows a close up view of a slice of bread. There are holes in the bread created by bubble of carbon dioxide.\" width=\"430\" height=\"357\"><figcaption id=\"caption-attachment-293\" class=\"wp-caption-text\"><em>Figure 4.11.3 Holes in bread created by carbon dioxide.<\/em><\/figcaption><\/figure>\n<p>Yeasts in bread dough also use alcoholic fermentation for\u00a0energy. They produce carbon dioxide\u00a0gas\u00a0as a waste product. The carbon dioxide released causes bubbles in the dough and explains why the dough rises. Do you see the small holes in the bread pictured\u00a0to the right? The holes were formed by bubbles of carbon dioxide\u00a0gas.<\/p>\n<div>\n<p>As you have probably guessed, yeast is also used in producing alcoholic beverages.\u00a0 When making beer, brewers will add yeast to a mix of barley and hops.\u00a0 In the absence of oxygen, yeast will carry out alcoholic fermentation in order to convert the glucose in the barley into energy, producing the alcohol content as well as the carbonation present in beer.<\/p>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Lactic Acid Fermentation<\/span><\/p>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1830\">Lactic acid fermentation<\/a><\/strong>\u00a0is carried out by certain\u00a0bacteria, including the bacteria in yogurt. It is also carried out by your muscle cells when you work them hard and fast. This is how the\u00a0muscles\u00a0of the sprinters pictured\u00a0above\u00a0get\u00a0energy\u00a0for their\u00a0short-lived \u2014\u00a0but intense \u2014 activity. When this happens, your muscles are using ATP faster than your cardiovascular system can deliver oxygen!\u00a0 The process\u00a0by\u00a0which this happens is summarized in the diagram\u00a0below. Again, the two pyruvic acid molecules shown in the diagram come from the splitting of glucose in the first stage of the process (glycolysis). It is also during this stage that two ATP molecules are produced. The rest of the processes produce lactic acid. Note that, unlike in alcoholic fermentation, there is no carbon dioxide waste product in lactic acid fermentation.<\/p>\n<figure id=\"attachment_293\" aria-describedby=\"caption-attachment-293\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-293 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lactic-Acid-Fermenation.jpg\" alt=\"Image shows a diagram of the formula of lactic acid fermentation, in which pyruvic acid is converted into lactic acid.\" width=\"500\" height=\"185\"><figcaption id=\"caption-attachment-293\" class=\"wp-caption-text\"><em>Figure 4.11.4 Lactic acid fermentation formula.<\/em><\/figcaption><\/figure>\n<div>\n<p>Lactic acid fermentation produces lactic acid and NAD+. The NAD+ cycles back to allow glycolysis to continue so more ATP is made. Each circle represents a carbon atom.<\/p>\n<\/div>\n<p>Did you ever run a race, lift heavy weights, or participate in some other intense activity and notice that your\u00a0muscles\u00a0start to feel a burning sensation? This may occur when your muscle cells use lactic acid fermentation to provide ATP for energy. The buildup of lactic acid in the muscles causes\u00a0a burning feeling.\u00a0This painful sensation is useful if it gets you to stop overworking your muscles and allow them a recovery period, during which cells can eliminate the lactic acid.<\/p>\n<div>\n<h1>Pros and Cons of Anaerobic Respiration<\/h1>\n<\/div>\n<p><em>With<\/em> oxygen, organisms can use\u00a0aerobic\u00a0cellular respiration to produce up to 38 molecules of ATP from just one molecule of glucose. <em>Without<\/em> oxygen, organisms must use anaerobic respiration to produce ATP, and this process produces only two molecules of ATP per molecule of glucose. Although anaerobic respiration produces less ATP, it has the advantage of doing so very quickly. For example, it allows your muscles to get the energy they need for short bursts of intense activity. Aerobic cellular respiration, in contrast, produces ATP more slowly.<\/p>\n<h1>Fermentation in Food Production<\/h1>\n<p>Anaerobic respiration is also used in the food industry.\u00a0 You read about yeast's role in making bread and beer, but did you know that there are many microbes that are used to create the food we eat, including cheese, sour cream, yogurt, soy sauce, olives, pepperoni, and many more.\u00a0 Watch the video below to learn more about fermentation in the food industry.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=eksagPy5tmQ&amp;t=3s<\/p>\n<p style=\"text-align: center\">The beneficial bacteria that make delicious food - Erez Garty, TED-Ed, 2016.<\/p>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.11 Cultural Connection<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p class=\"textbox__title\" style=\"margin-top: 2.14286em;margin-bottom: 1.42857em;line-height: 1.28571em;color: #ffffff\"><span style=\"color: #000000\">Fishing has always been part of the culture and nutrition of Indigenous peoples living on the west coast of Canada.\u00a0 Fish provides delicious important nutrients such as protein, Omega-3 fatty acids, calcium, iron, and Vitamins A, B, C and D.\u00a0 Traditionally, no part of the fish was wasted, including head, eyes, internal organs, and eggs.<\/span><\/p>\n<p>Eulachon, also known as candle fish or oolichan, (pictured below) have been prized for their oil for thousands of years. The pathways of these fish dictated \"grease trails\" and are found from Bristol Bay, Alaska, all the way south to the Klamath River, California.\u00a0 Within BC, the areas of Nass, Knights Inlet, and Bella Coola had large trading centres for this important natural resource.<\/p>\n<div id=\"h5p-46\">\n<div class=\"h5p-content\" data-content-id=\"46\"><\/div>\n<\/div>\n<p>Photos by Brodie Guy - <a href=\"https:\/\/brodieguy.com\/\">www.brodieguy.com<\/a> <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/\">CC BY-NC-ND 4.0<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Euchalon were and are eaten fresh, smoked or dried, and as grease.\u00a0 The grease remains a highly valued food to Indigenous coastal communities.\u00a0 The flavour of the grease varies greatly depending not only on where the fish is from and how it is made, but also how long it is left to ferment.\u00a0 To ferment the eulachon, fish are left in a wood-lined locker dug into the soil for 10 days.\u00a0 Fermentation uses the action of fungi and bacteria to break down the fish making oil extraction much faster and easier.<\/p>\n<p>To learn more, visit the <a href=\"https:\/\/www.fnha.ca\/Documents\/Traditional_Food_Fact_Sheets.pdf\">First Nations Health Authority Traditional Foods Fact Sheet<\/a> and a feature in the Yukon News, <a href=\"https:\/\/www.yukon-news.com\/business\/eulachon-oolichan-hooligan-a-fish-by-any-other-name-is-just-as-oily\/\">\"Eulachon, oolicahn, hooligan: A fish by any other name is just as oily.\"<\/a><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.11 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The cells of most living things produce <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2072\">ATP<\/a> from glucose by aerobic cellular respiration, which uses oxygen. Some organisms instead produce ATP from glucose by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2163\">anaerobic respiration<\/a>, which does not require oxygen.<\/li>\n<li>An important way of making ATP without oxygen is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2670\">fermentation<\/a>. There are two types of fermentation: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2506\">alcoholic fermentation<\/a> and lactic acid fermentation. Both start with glycolysis, the first (anaerobic) stage of cellular respiration, in which two molecules of ATP are produced from one molecule of glucose.<\/li>\n<li>Alcoholic fermentation is carried out by single-celled organisms, including yeasts and some\u00a0bacteria. We use alcoholic fermentation in these organisms to make biofuels, bread, and wine.<\/li>\n<li>Lactic acid fermentation is undertaken by certain bacteria, including the bacteria in yogurt, and also by our muscle cells when they are worked hard and fast.<\/li>\n<li>Anaerobic respiration produces <em>far<\/em> less ATP than does aerobic cellular respiration, but it has the advantage of being much faster. For example, it allows muscles to get the energy they need for short bursts of intense activity.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.11 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Explain\u00a0the primary\u00a0difference between aerobic cellular respiration and anaerobic respiration.<\/li>\n<li>What is fermentation?<\/li>\n<li>Compare and contrast alcoholic and lactic acid fermentation.<\/li>\n<li>Identify the major pros and the major cons of anaerobic respiration relative to aerobic cellular respiration.<\/li>\n<li>What process is shared between aerobic cellular respiration and anaerobic respiration? Describe the process briefly. Why can this process happen in anaerobic respiration, as well as aerobic respiration?<\/li>\n<li>\n<div id=\"h5p-47\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-47\" class=\"h5p-iframe\" data-content-id=\"47\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Fermentation\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What is the reactant (or starting material)common to\u00a0aerobic respiration and both types of fermentation?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.11 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=cDC29iBxb3w&amp;t=3s<\/p>\n<p style=\"text-align: center\">Anaerobic Respiration, Bozeman Science, 2013.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=YbdkbCU20_M<\/p>\n<p style=\"text-align: center\">Fermentation, The Amoeba Sisters, 2018.<\/p>\n<p>https:\/\/www.youtube.com\/watch?time_continue=17&amp;v=TVtqwWGguFk&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Science of Beer: Tapping the Power of Brewer's Yeast, KQED Science, 2014.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.11.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/3R4vPrSB1c4\" rel=\"cc:attributionURL\">Sprinters<\/a> by <a href=\"https:\/\/unsplash.com\/@jon_chng\">Jonathan Chng<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 4.11.2<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/CK-12-College-Human-Biology\/section\/4.11\/\" rel=\"cc:attributionURL\">Alcoholic fermentation<\/a> by Hana Zavadska\/ CK-12 Foundation is used under a <a class=\" dxtrack-user-action Link__LinkItem-sc-15rka1e-0 kxTgHz\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-dx-desc=\"course_modality_image_attribution_license\"><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\">CC BY-NC 3.0<\/span><\/a><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\"> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.\u00a0<\/span><\/p>\n<div><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a><\/div>\n<div>\n<div>Licensed under\u00a0<a href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a>\u00a0\u2022\u00a0<a href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a>\u00a0\u2022\u00a0<a href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/div>\n<\/div>\n<p><strong>Figure 4.11.3<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/PffLsy3sB4U\" rel=\"cc:attributionURL\">Bread [photo]<\/a> by <a href=\"https:\/\/unsplash.com\/@orlovamaria\">Orlova Maria<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 4.11.4<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/CK-12-College-Human-Biology\/section\/4.11\/\" rel=\"cc:attributionURL\">Lactic Acid Fermenation<\/a> by Hana Zavadska\/ CK-12 Foundation is used under a <a class=\" dxtrack-user-action Link__LinkItem-sc-15rka1e-0 kxTgHz\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-dx-desc=\"course_modality_image_attribution_license\"><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\">CC BY-NC 3.0<\/span><\/a><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\"> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.\u00a0<\/span><\/p>\n<div><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em\">Licensed under\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/div>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Bozeman Science. (2013, May 2). Anaerobic respiration. YouTube. https:\/\/www.youtube.com\/watch?v=cDC29iBxb3w&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Hana Zavadska\/CK-12 Foundation. (2016, August 15). Figure 2: Alcoholic fermentation\u00a0 [digital image]. In Brainard, J., and Henderson, R., <em>CK-12\u2019s College Human Biology FlexBook\u00ae<\/em> (Section 4.11). CK-12 Foundation. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/4.11\/<\/p>\n<p class=\"hanging-indent\">Hana Zavadska\/CK-12 Foundation. (2016, August 15). Figure 4: Lactic acid fermentation [digital image]. In Brainard, J., and Henderson, R., <em>CK-12\u2019s College Human Biology<\/em> FlexBook\u00ae (Section 4.11). CK-12 Foundation. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/4.11\/<\/p>\n<p class=\"hanging-indent\">First Nations Health Authority. (2019, September 6). First Nations traditional foods facts Sheet [pdf]. https:\/\/www.fnha.ca\/Documents\/Traditional_Food_Fact_Sheets.pdf<\/p>\n<p class=\"hanging-indent\">Genest, M. (2017, May 24)<em>. <\/em>Eulachon, oolichan, hooligan: A fish by any other name is just as oily [online article]. YukonNews.com. https:\/\/www.yukon-news.com\/business\/eulachon-oolichan-hooligan-a-fish-by-any-other-name-is-just-as-oily\/<\/p>\n<p class=\"hanging-indent\">KQED Science. (2014, February 11). Science of beer: Tapping the power of brewer's yeast. YouTube. https:\/\/www.youtube.com\/watch?v=TVtqwWGguFk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2016). The beneficial bacteria that make delicious food - Erez Garty. YouTube. https:\/\/www.youtube.com\/watch?v=eksagPy5tmQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">The Amoeba Sisters. (2018, April 30). Fermentation. YouTube. https:\/\/www.youtube.com\/watch?v=YbdkbCU20_M&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 21). Ethanol fuel. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Ethanol_fuel&amp;oldid=963675942<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_5999\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_5999\"><div tabindex=\"-1\"><p>The body system responsible for the elimination of wastes produced by homeostasis. There are several parts of the body that are involved in this process, such as sweat glands, the liver, the lungs and the kidney system. ... From there, urine is expelled through the urethra and out of the body.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4720_2916\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4720_2916\"><div tabindex=\"-1\"><p>Created by:\u00a0CK-12\/Adapted by Christine Miller<\/p>\n<h1>Divide and Split<\/h1>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 400px\" class=\"wp-caption alignright\"><img class=\"wp-image-303\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Anaphase_IF.jpg\" alt=\"Image shows a cell in anaphase of mitosis. The image is taken using immunoflourescence microscopy and components of the cell including spindle fibers and genetic material show as vivid blues and greens.\" width=\"400\" height=\"400\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.1 A cell in anaphase of mitosis. <\/em><\/figcaption><\/figure>\n<p>Can you guess what the colourful image in Figure 4.13.1 represents? It shows a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> cell during the process of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2186\">cell division<\/a>. In particular, the image shows the cell in a part of cell division called anaphase, where the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_277\">DNA<\/a> is being pulled to opposite ends of the cell. Normally, DNA is located in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2402\">nucleus<\/a> of most human cells. The nucleus divides before the cell itself splits in two, and before the nucleus divides, the cell\u2019s DNA is replicated (or copied). There must be two copies of the DNA so that each daughter cell will have a complete copy of the genetic material from the parent cell. How is the replicated DNA sorted and separated so that each daughter cell gets a complete set of the genetic material? To answer that question, you first need to know more about DNA and the forms it takes.<\/p>\n<div>\n<h1>The Forms of\u00a0DNA<\/h1>\n<\/div>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 380px\" class=\"wp-caption alignright\"><img class=\"wp-image-304\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Chromosomes.png\" alt=\"Diagram shows the forms that DNA takes, as a double helix, which will coil around itself, which will ultimately form a chromosome.\" width=\"380\" height=\"408\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.2 Forms of DNA. <\/em><\/figcaption><\/figure>\n<p>Except when a eukaryotic cell divides, its nuclear DNA exists as a grainy material called\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1997\"><strong>chromatin<\/strong><\/a>.\u00a0Only once a cell is about to divide and its DNA has replicated does DNA condense and coil into the familiar X-shaped form of a\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2166\"><strong>chromosome<\/strong><\/a><strong>,<\/strong>\u00a0like the one shown\u00a0below.<\/p>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 344px\" class=\"wp-caption alignleft\"><img class=\"wp-image-305\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Chromosome-chromatid-sister-chromatid.png\" alt=\"Labelled diagram of a chromosome showing that in a chromosome with the typical &quot;X&quot; shape, it is comprised of two identical pieces of DNA, each called a chromatid.\" width=\"344\" height=\"278\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.3 Diagram of a chromosome showing that in a chromosome with the typical \"X\" shape, it is comprised of two identical pieces of DNA, each called a chromatid.<\/em><\/figcaption><\/figure>\n<p>Most\u00a0cells\u00a0in the\u00a0human body\u00a0have\u00a0two\u00a0pairs of 23 different\u00a0chromosomes, for a total of 46 chromosomes.\u00a0Cells\u00a0that have two\u00a0pairs of\u00a0chromosomes\u00a0are called diploid.\u00a0Because DNA has already replicated when it coils into a chromosome, each chromosome actually consists of two identical\u00a0structures called\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1999\"><strong>sister<\/strong>\u00a0<strong>chromatids<\/strong><\/a><strong>.<\/strong>\u00a0Sister chromatids are joined together at a region called a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2030\">centromere<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h1><\/h1>\n<h1>Mitosis<\/h1>\n<\/div>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 414px\" class=\"wp-caption alignright\"><img class=\"wp-image-306\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Aimple-Mitosis.png\" alt=\"Diagram shows the stages of Mitosis in which DNA replicates, chromosomes align, sister chromatids separate, and then two diploid cell emerge.\" width=\"414\" height=\"370\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.4 Mitosis is the phase of the eukaryotic cell cycle that occurs between DNA replication and the formation of two daughter cells. What happens during mitosis?<\/em><\/figcaption><\/figure>\n<p>The process in which the\u00a0nucleus\u00a0of a eukaryotic cell divides is called\u00a0<strong>mitosis.<\/strong>\u00a0During mitosis, the two sister chromatids that make up each chromosome separate from each other and move to opposite poles of the cell. This is shown in the figure\u00a0below.<\/p>\n<p>Mitosis actually occurs in four phases. The phases are called prophase, metaphase, anaphase, and telophase.<\/p>\n<h2><\/h2>\n<h2><\/h2>\n<h2 style=\"text-align: left\">Prophase<\/h2>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 75px\" class=\"wp-caption alignleft\"><img class=\"wp-image-307\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Prophasetiny.png\" alt=\"\" width=\"75\" height=\"79\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.5 Mitotic prophase.<\/em><\/figcaption><\/figure>\n<p>The first and longest phase of mitosis is\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2006\"><strong>prophase<\/strong><\/a>. During prophase, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1997\">chromatin<\/a> condenses into\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2166\">chromosomes<\/a>, and the nuclear envelope (the membrane surrounding the nucleus) breaks down. In animal cells, the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2093\">centrioles<\/a>\u00a0near the\u00a0nucleus\u00a0begin to separate and move to opposite poles of the cell.\u00a0<strong>Centrioles<\/strong> are small organelles found only in eukaryotic cells. They help ensure that the new cells that form after cell division each contain a complete set of chromosomes. As the centrioles move apart, a spindle starts to form between them. The spindle consists of fibres made of microtubules.<\/p>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 541px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-308\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/512px-Prophase_eukaryotic_mitosis.svg_.png\" alt=\"Diagram shows a cell in prophase of mitosis. The nuclear envelope is breaking down, chromosomes are condensing, and spindle fibers are forming.\" width=\"541\" height=\"380\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.6 Diagram of a cell in prophase of mitosis. <\/em><\/figcaption><\/figure>\n<div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 1.424em;font-weight: bold\">Metaphase<\/span><\/p>\n<\/div>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 89px\" class=\"wp-caption alignleft\"><img class=\"wp-image-309\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/500px-Mitotic_Metaphase.svg_.png\" alt=\"\" width=\"89\" height=\"74\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\">Figure 4.13.7 M<em>etaphase.<\/em><\/figcaption><\/figure>\n<p>During\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2029\">metaphase<\/a><\/strong>, spindle fibres attach to the centromere of each pair of sister chromatids. As you can see in Figure 4.13.7, the sister chromatids line up at the equator (or center) of the cell. The spindle fibres ensure that sister chromatids will separate and go to different daughter cells when the cell divides.<\/p>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 543px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-310\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2000px-Metaphase_eukaryotic_mitosis.svg_.png\" alt=\"Diagram shows metaphase of mitosis, in which the spindle fibers are fully formed and the chromosomes are aligned along the center of the cell.\" width=\"543\" height=\"381\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.8 Diagram showing the metaphase of mitosis. <\/em><\/figcaption><\/figure>\n<h2>Anaphase<\/h2>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 114px\" class=\"wp-caption alignleft\"><img class=\"wp-image-311\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anaphase.png\" alt=\"\" width=\"114\" height=\"97\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.9 Mitotic anaphase.<\/em><\/figcaption><\/figure>\n<p>During\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2031\">anaphase<\/a><\/strong>, sister chromatids separate and the centromeres divide. The sister chromatids are pulled apart by the shortening of the spindle fibres. This is a little like reeling in a fish by shortening the fishing line. One sister chromatid moves to one pole of the cell, and the other sister chromatid moves to the opposite pole. At the end of anaphase, each pole of the cell has a complete set of chromosomes.<\/p>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 541px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-312\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Anaphase_eukaryotic_mitosis.svg_.png\" alt=\"Image shows a eukaryotic cell in anaphase of the cell cycle, in which sister chromatids have been separated from each other and are being pulled to opposite ends of the cell by spindle fibers.\" width=\"541\" height=\"381\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.10 Diagram showing eukaryotic cell in anaphase of cell cycle. <\/em><\/figcaption><\/figure>\n<h2>Telophase<\/h2>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 113px\" class=\"wp-caption alignleft\"><img class=\"wp-image-313\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Mitotic_Telophase.svg_.png\" alt=\"\" width=\"113\" height=\"70\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.11 Mitotic telophase.<\/em><\/figcaption><\/figure>\n<p>During\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2037\">telophase<\/a><\/strong>, the chromosomes begin to uncoil and form chromatin. This prepares the genetic material for directing the metabolic activities of the new cells. The spindle also breaks down, and new nuclear envelopes form.<\/p>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 540px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-314\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Telophase_eukaryotic_mitosis.svg_.png\" alt=\"Telophase is the stage in mitosis in which the nuclear envelope starts to reform, the chromosomes decondense and the cell continues to elongate.\" width=\"540\" height=\"380\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.12 Diagram showing telophase in mitosis. <\/em><\/figcaption><\/figure>\n<div>\n<h1>Cytokinesis<\/h1>\n<\/div>\n<figure id=\"attachment_315\" aria-describedby=\"caption-attachment-315\" style=\"width: 128px\" class=\"wp-caption alignleft\"><img class=\"size-full wp-image-315\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/128px-Mitotic_Cytokinesis.svg_.png\" alt=\"\" width=\"128\" height=\"79\"><figcaption id=\"caption-attachment-315\" class=\"wp-caption-text\"><em>Figure 4.13.13 Mitotic cytokinesis.<\/em><\/figcaption><\/figure>\n<p><strong>Cytokinesis<\/strong>\u00a0is the final stage of\u00a0cell division. During cytokinesis, the cytoplasm splits in two and the cell divides, as shown\u00a0below. In\u00a0animal cells, the\u00a0plasma membrane\u00a0of the parent cell pinches inward along the cell\u2019s equator until two daughter cells form.\u00a0Thus, the goal of\u00a0mitosis and cytokinesis\u00a0is now complete, because one parent cell\u00a0has given\u00a0rise to two daughter cells. The daughter cells have the same chromosomes as the parent cell.<\/p>\n<div>\n<figure id=\"attachment_316\" aria-describedby=\"caption-attachment-316\" style=\"width: 542px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-316\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cytokinesis_eukaryotic_mitosis.svg_.png\" alt=\"Cytokinesis is the final step in cell division, in which the cytoplasm of the two new daughter cells completely separates.\" width=\"542\" height=\"381\"><figcaption id=\"caption-attachment-316\" class=\"wp-caption-text\"><em>Figure 4.13.14 Diagram showing the final step in cell division: cytokinesis. <\/em><\/figcaption><\/figure>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.13 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Until a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1573\">eukaryotic<\/a> cell divides, its nuclear <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_277\">DNA<\/a> exists as a grainy material called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1997\">chromatin<\/a>. After DNA replicates and the cell is about to divide, the DNA condenses and coils into the X-shaped form of a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2166\">chromosome<\/a>. Each chromosome actually consists of two <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_1999\">sister chromatids<\/a>, which are joined together at a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4720_2030\">centromere<\/a>.<\/li>\n<li>Mitosis is the process during which the nucleus of a eukaryotic cell divides. During this process, sister chromatids separate from each other and move to opposite poles of the cell. This happens in four phases: prophase, metaphase, anaphase, and telophase.<\/li>\n<li>Cytokinesis is the final stage of cell division, during which the cytoplasm splits in two and two daughter cells form.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.13 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Describe the different forms that DNA takes before and during cell division in a eukaryotic cell.<\/li>\n<li>\n<div id=\"h5p-49\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-49\" class=\"h5p-iframe\" data-content-id=\"49\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"4.13 Review Questions\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Identify the four phases of mitosis in an animal cell, and summarize what happens during each phase.<\/li>\n<li>Order the diagrams of the stages of mitosis:\n<div id=\"h5p-50\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-50\" class=\"h5p-iframe\" data-content-id=\"50\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Mitosis - Image Sequencing\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Explain what happens during cytokinesis in an animal cell.<\/li>\n<li>What do you think would happen if the sister chromatids of one of the chromosomes did not separate during mitosis?<\/li>\n<li>True or False:\n<div id=\"h5p-51\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-51\" class=\"h5p-iframe\" data-content-id=\"51\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Mitosis and Cytokinesis True\/False\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">4.13 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?time_continue=3&amp;v=C6hn3sA0ip0&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Mitosis, NDSU Virtual Cell Animations project (ndsuvirtualcell), 2012.<\/p>\n<p>https:\/\/www.youtube.com\/watch?time_continue=19&amp;v=EA0qxhR2oOk&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Nondisjunction (Trisomy 21) - An Animated Tutorial, Kristen Koprowski, 2012.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.13.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anaphase_IF.jpg\" rel=\"cc:attributionURL\">Anaphase_IF<\/a> by Roy van Heesbeen on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.2<\/strong><\/p>\n<p><a href=\"https:\/\/pixabay.com\/vectors\/genetics-chromosomes-rna-dna-156404\/\" rel=\"cc:attributionURL\">Chromosomes<\/a>\u00a0by\u00a0<a href=\"https:\/\/pixabay.com\/users\/openclipart-vectors-30363\/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=156404\" rel=\"dc:creator\">OpenClipArt-Vectors<\/a> on <a href=\"https:\/\/pixabay.com\/\">Pixabay<\/a> is used under the <a href=\"https:\/\/pixabay.com\/service\/license\/\">Pixabay License<\/a> (https:\/\/pixabay.com\/service\/license\/).<\/p>\n<p><strong>Figure 4.13.3<\/strong><\/p>\n<p>Chromosome\/ Chromatid\/ Sister Chromatid by Christine Miller is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.4<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/CK-12-College-Human-Biology\/section\/4.13\/\" rel=\"cc:attributionURL\">Simple Mitosis<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> via <a href=\"https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/\">CK-12 Foundation<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\">CC BY-NC 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.<\/p>\n<p><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\"> <span style=\"font-size: 1em\">\u00a9<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em\">Licensed under\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\"><\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/p>\n<p><strong>Figure 4.13.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Mitotic_Prophase.svg\" rel=\"cc:attributionURL\">Mitotic Prophase [tiny]<\/a>\u00a0by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.6<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Prophase_eukaryotic_mitosis.svg\" rel=\"cc:attributionURL\">Prophase Eukaryotic Mitosis<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.7<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Mitotic_Metaphase.svg\" rel=\"cc:attributionURL\">Mitotic_Metaphase<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.8<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Metaphase_eukaryotic_mitosis.svg\" rel=\"cc:attributionURL\">Metaphase Eukaryotic Mitosis<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.9<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?curid=6767015\" rel=\"cc:attributionURL\">Anaphase<\/a> [adapted] by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.10<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Anaphase_eukaryotic_mitosis.svg\" rel=\"cc:attributionURL\">Anaphase_eukaryotic_mitosis.svg<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.11<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Mitotic_Telophase.svg\" rel=\"cc:attributionURL\">Mitotic Telophase<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.12<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Telophase_eukaryotic_mitosis.svg\">Telophase Eukaryotic Mitosis<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.13<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Mitotic_Cytokinesis.svg\">Mitotic Cytokinesis<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.13.14<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cytokinesis_eukaryotic_mitosis.svg\">Cytokinesis Eukaryotic Mitosis<\/a> by Mariana Ruiz Villarreal [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\" rel=\"dc:creator\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Koprowski, K., Cabey, R. [Kristen Koprowski]. (2012). Nondisjunction (Trisomy 21) - An Animated Tutorial. YouTube. https:\/\/www.youtube.com\/watch?v=EA0qxhR2oOk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">NDSU Virtual Cell Animations project [ndsuvirtualcell]. (2012). Mitosis. YouTube. https:\/\/www.youtube.com\/watch?v=C6hn3sA0ip0&amp;t=21s<\/p>\n<\/div>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"author":32,"menu_order":5,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":"cc-by-nc"},"chapter-type":[48],"contributor":[],"license":[55],"class_list":["post-4720","chapter","type-chapter","status-publish","hentry","chapter-type-numberless","license-cc-by-nc"],"part":4681,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/users\/32"}],"version-history":[{"count":4,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4720\/revisions"}],"predecessor-version":[{"id":6429,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4720\/revisions\/6429"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/parts\/4681"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4720\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/media?parent=4720"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapter-type?post=4720"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/contributor?post=4720"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/license?post=4720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}