{"id":4478,"date":"2019-06-24T12:45:03","date_gmt":"2019-06-24T12:45:03","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/4-11-anaerobic-processes-3\/"},"modified":"2023-11-30T17:54:56","modified_gmt":"2023-11-30T17:54:56","slug":"4-11-anaerobic-processes-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/4-11-anaerobic-processes-3\/","title":{"raw":"4.11\u00a0Anaerobic Processes","rendered":"4.11\u00a0Anaerobic Processes"},"content":{"raw":"&nbsp;\r\n\r\n[caption id=\"attachment_1825\" align=\"aligncenter\" width=\"400\"]<img class=\"wp-image-1825\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Sprinters-e1564874496956-2.jpg\" alt=\"Image shows a photo of women in a short distance running race on a track.\" width=\"400\" height=\"391\" \/> <em>Figure 4.11.1 Sprinters racing on a track.\u00a0<\/em>[\/caption]\r\n<h1>Fast and Furious<\/h1>\r\nThese sprinters' muscles\u00a0will need a lot of\u00a0energy\u00a0to complete this short race, because they will be running at top\u00a0speed. The action won't last long, but it will be very intense. The energy each sprinter needs can't be provided quickly enough by aerobic\u00a0cellular respiration. Instead,\u00a0their muscle\u00a0cells must use a\u00a0different process to power their activity.\r\n<div>\r\n<h1>Making ATP Without Oxygen<\/h1>\r\n<\/div>\r\nLiving things'\u00a0cells\u00a0power their activities with the energy-carrying molecule [pb_glossary id=\"5549\"]ATP[\/pb_glossary] (adenosine triphosphate). The\u00a0cells\u00a0of most living things make ATP from [pb_glossary id=\"5451\"]glucose[\/pb_glossary] in the process of [pb_glossary id=\"5725\"]cellular respiration[\/pb_glossary]. This process occurs in three stages:\u00a0[pb_glossary id=\"1798\"]glycolysis[\/pb_glossary], the\u00a0[pb_glossary id=\"1805\"]Krebs cycle[\/pb_glossary], and\u00a0[pb_glossary id=\"5473\"]electron transport[\/pb_glossary]. The latter two stages require oxygen, making cellular respiration an [pb_glossary id=\"1796\"]aerobic[\/pb_glossary] process. When oxygen is not available in cells, the ETS quickly shuts down.\u00a0 Luckily, there are also ways of making ATP from glucose which are\u00a0<strong>[pb_glossary id=\"1826\"]anaerobic[\/pb_glossary],<\/strong>\u00a0which means that they do not require oxygen. These processes are referred to collectively as\u00a0<strong>[pb_glossary id=\"5617\"]anaerobic respiration[\/pb_glossary]<\/strong>.\r\n<div>\r\n<h1>Fermentation<\/h1>\r\n<\/div>\r\nOme important way of making ATP without oxygen is\u00a0<strong>[pb_glossary id=\"6003\"]fermentation[\/pb_glossary].\u00a0<\/strong>Fermentation starts with\u00a0[pb_glossary id=\"1798\"]glycolysis[\/pb_glossary], which does not require oxygen, but it does not involve the latter two stages of aerobic cellular respiration (the\u00a0[pb_glossary id=\"1805\"]Krebs cycle[\/pb_glossary]\u00a0and\u00a0[pb_glossary id=\"5473\"]electron\u00a0transport[\/pb_glossary]).\u00a0There are two types of fermentation:\u00a0[pb_glossary id=\"5879\"]alcoholic fermentation[\/pb_glossary]\u00a0and [pb_glossary id=\"1830\"]lactic\u00a0acid\u00a0fermentation[\/pb_glossary]. We make use of both types of fermentation\u00a0using other\u00a0organisms, but only lactic\u00a0acid\u00a0fermentation actually takes place inside the\u00a0human body.\r\n<h2>Alcoholic Fermentation<\/h2>\r\n[caption id=\"attachment_1831\" align=\"alignleft\" width=\"443\"]<img class=\" wp-image-1831\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/alcoholic-fermentation-2.jpg\" alt=\"\" width=\"443\" height=\"164\" \/> <em>Figure 4.11.2 In alcoholic fermentation, pyruvate is converted to ethanol and carbon dioxide.\u00a0 During this process, NAD+ is formed, which allows glycolysis to continue making ATP.<\/em>[\/caption]\r\n\r\n<strong>[pb_glossary id=\"5879\"]Alcoholic fermentation[\/pb_glossary]\u00a0<\/strong>is carried out by single-celled\u00a0fungi\u00a0(called yeasts), as well as some\u00a0bacteria. We use alcoholic fermentation in these organisms to make [pb_glossary id=\"1832\"]biofuels[\/pb_glossary], bread, and wine. The <a href=\"https:\/\/en.wikipedia.org\/wiki\/Ethanol_fuel\">biofuel ethanol<\/a> (a type of alcohol), for example, is produced by alcoholic fermentation of the glucose in corn or other plants. The process by which this happens is summarized in the diagram\u00a0below. The two pyruvic acid molecules shown in the diagram come from the splitting of glucose in the first stage of the process (glycolysis). ATP is\u00a0also made during\u00a0glycolysis. Two molecules of ATP are produced from each molecule of glucose.\r\n\r\n[caption id=\"attachment_1833\" align=\"alignright\" width=\"430\"]<img class=\"wp-image-1833\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Bread-e1564876273763-2.jpg\" alt=\"Image shows a close up view of a slice of bread. There are holes in the bread created by bubble of carbon dioxide.\" width=\"430\" height=\"357\" \/> <em>Figure 4.11.3 Holes in bread created by carbon dioxide.<\/em>[\/caption]\r\n\r\nYeasts in bread dough also use alcoholic fermentation for\u00a0energy. They produce carbon dioxide\u00a0gas\u00a0as a waste product. The carbon dioxide released causes bubbles in the dough and explains why the dough rises. Do you see the small holes in the bread pictured\u00a0to the right? The holes were formed by bubbles of carbon dioxide\u00a0gas.\r\n<div>\r\n\r\nAs you have probably guessed, yeast is also used in producing alcoholic beverages.\u00a0 When making beer, brewers will add yeast to a mix of barley and hops.\u00a0 In the absence of oxygen, yeast will carry out alcoholic fermentation in order to convert the glucose in the barley into energy, producing the alcohol content as well as the carbonation present in beer.\r\n\r\n<span style=\"font-size: 1.424em; font-weight: bold;\">Lactic Acid Fermentation<\/span>\r\n\r\n<\/div>\r\n<strong>[pb_glossary id=\"1830\"]Lactic acid fermentation[\/pb_glossary]<\/strong>\u00a0is carried out by certain\u00a0bacteria, including the bacteria in yogurt. It is also carried out by your muscle cells when you work them hard and fast. This is how the\u00a0muscles\u00a0of the sprinters pictured\u00a0above\u00a0get\u00a0energy\u00a0for their\u00a0short-lived \u2014\u00a0but intense \u2014 activity. When this happens, your muscles are using ATP faster than your cardiovascular system can deliver oxygen!\u00a0 The process\u00a0by\u00a0which this happens is summarized in the diagram\u00a0below. Again, the two pyruvic acid molecules shown in the diagram come from the splitting of glucose in the first stage of the process (glycolysis). It is also during this stage that two ATP molecules are produced. The rest of the processes produce lactic acid. Note that, unlike in alcoholic fermentation, there is no carbon dioxide waste product in lactic acid fermentation.\r\n\r\n[caption id=\"attachment_1908\" align=\"aligncenter\" width=\"500\"]<img class=\"wp-image-1908 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lactic-Acid-Fermenation-2.jpg\" alt=\"Image shows a diagram of the formula of lactic acid fermentation, in which pyruvic acid is converted into lactic acid.\" width=\"500\" height=\"185\" \/> <em>Figure 4.11.4 Lactic acid fermentation formula.<\/em>[\/caption]\r\n\r\n<div>\r\n\r\nLactic acid fermentation produces lactic acid and NAD+. The NAD+ cycles back to allow glycolysis to continue so more ATP is made. Each circle represents a carbon atom.\r\n\r\n<\/div>\r\nDid you ever run a race, lift heavy weights, or participate in some other intense activity and notice that your\u00a0muscles\u00a0start to feel a burning sensation? This may occur when your muscle cells use lactic acid fermentation to provide ATP for energy. The buildup of lactic acid in the muscles causes\u00a0a burning feeling.\u00a0This painful sensation is useful if it gets you to stop overworking your muscles and allow them a recovery period, during which cells can eliminate the lactic acid.\r\n<div>\r\n<h1>Pros and Cons of Anaerobic Respiration<\/h1>\r\n<\/div>\r\n<em>With<\/em> oxygen, organisms can use\u00a0aerobic\u00a0cellular respiration to produce up to 38 molecules of ATP from just one molecule of glucose. <em>Without<\/em> oxygen, organisms must use anaerobic respiration to produce ATP, and this process produces only two molecules of ATP per molecule of glucose. Although anaerobic respiration produces less ATP, it has the advantage of doing so very quickly. For example, it allows your muscles to get the energy they need for short bursts of intense activity. Aerobic cellular respiration, in contrast, produces ATP more slowly.\r\n<h1>Fermentation in Food Production<\/h1>\r\nAnaerobic respiration is also used in the food industry.\u00a0 You read about yeast's role in making bread and beer, but did you know that there are many microbes that are used to create the food we eat, including cheese, sour cream, yogurt, soy sauce, olives, pepperoni, and many more.\u00a0 Watch the video below to learn more about fermentation in the food industry.\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=eksagPy5tmQ&amp;t=3s\r\n<p style=\"text-align: center;\">The beneficial bacteria that make delicious food - Erez Garty, TED-Ed, 2016.<\/p>\r\n\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.11 Cultural Connection<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<p class=\"textbox__title\" style=\"margin-top: 2.14286em; margin-bottom: 1.42857em; line-height: 1.28571em; color: #ffffff;\"><span style=\"color: #000000;\">Fishing has always been part of the culture and nutrition of Indigenous peoples living on the west coast of Canada.\u00a0 Fish provides delicious important nutrients such as protein, Omega-3 fatty acids, calcium, iron, and Vitamins A, B, C and D.\u00a0 Traditionally, no part of the fish was wasted, including head, eyes, internal organs, and eggs.<\/span><\/p>\r\nEulachon, also known as candle fish or oolichan, (pictured below) have been prized for their oil for thousands of years. The pathways of these fish dictated \"grease trails\" and are found from Bristol Bay, Alaska, all the way south to the Klamath River, California.\u00a0 Within BC, the areas of Nass, Knights Inlet, and Bella Coola had large trading centres for this important natural resource.\r\n\r\n[h5p id=\"480\"]\r\n\r\nPhotos by Brodie Guy - <a href=\"https:\/\/brodieguy.com\/\">www.brodieguy.com<\/a> <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/\">CC BY-NC-ND 4.0<\/a>\r\n\r\n&nbsp;\r\n\r\nEuchalon were and are eaten fresh, smoked or dried, and as grease.\u00a0 The grease remains a highly valued food to Indigenous coastal communities.\u00a0 The flavour of the grease varies greatly depending not only on where the fish is from and how it is made, but also how long it is left to ferment.\u00a0 To ferment the eulachon, fish are left in a wood-lined locker dug into the soil for 10 days.\u00a0 Fermentation uses the action of fungi and bacteria to break down the fish making oil extraction much faster and easier.\r\n\r\nTo learn more, visit the <a href=\"https:\/\/www.fnha.ca\/Documents\/Traditional_Food_Fact_Sheets.pdf\">First Nations Health Authority Traditional Foods Fact Sheet<\/a> and a feature in the Yukon News, <a href=\"https:\/\/www.yukon-news.com\/business\/eulachon-oolichan-hooligan-a-fish-by-any-other-name-is-just-as-oily\/\">\"Eulachon, oolicahn, hooligan: A fish by any other name is just as oily.\"<\/a>\r\n\r\n<\/div>\r\n&nbsp;\r\n\r\n<\/div>\r\n&nbsp;\r\n<div>\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.11 Summary<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul>\r\n \t<li>The cells of most living things produce [pb_glossary id=\"5549\"]ATP[\/pb_glossary] from glucose by aerobic cellular respiration, which uses oxygen. Some organisms instead produce ATP from glucose by [pb_glossary id=\"5617\"]anaerobic respiration[\/pb_glossary], which does not require oxygen.<\/li>\r\n \t<li>An important way of making ATP without oxygen is [pb_glossary id=\"6003\"]fermentation[\/pb_glossary]. There are two types of fermentation: [pb_glossary id=\"5879\"]alcoholic fermentation[\/pb_glossary] and [pb_glossary id=\"1912\"]lactic acid fermentation[\/pb_glossary]. Both start with [pb_glossary id=\"1798\"]glycolysis[\/pb_glossary], the first (anaerobic) stage of cellular respiration, in which two molecules of ATP are produced from one molecule of glucose.<\/li>\r\n \t<li>Alcoholic fermentation is carried out by single-celled organisms, including yeasts and some\u00a0bacteria. We use alcoholic fermentation in these organisms to make biofuels, bread, and wine.<\/li>\r\n \t<li>Lactic acid fermentation is undertaken by certain bacteria, including the bacteria in yogurt, and also by our muscle cells when they are worked hard and fast.<\/li>\r\n \t<li>Anaerobic respiration produces <em>far<\/em> less ATP than does aerobic cellular respiration, but it has the advantage of being much faster. For example, it allows muscles to get the energy they need for short bursts of intense activity.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.11 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ol>\r\n \t<li>Explain\u00a0the primary\u00a0difference between aerobic cellular respiration and anaerobic respiration.<\/li>\r\n \t<li>What is fermentation?<\/li>\r\n \t<li>Compare and contrast alcoholic and lactic acid fermentation.<\/li>\r\n \t<li>Identify the major pros and the major cons of anaerobic respiration relative to aerobic cellular respiration.<\/li>\r\n \t<li>What process is shared between aerobic cellular respiration and anaerobic respiration? Describe the process briefly. Why can this process happen in anaerobic respiration, as well as aerobic respiration?<\/li>\r\n \t<li>[h5p id=\"481\"]<\/li>\r\n \t<li>What is the reactant (or starting material)common to\u00a0aerobic respiration and both types of fermentation?<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.11 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=cDC29iBxb3w&amp;t=3s\r\n<p style=\"text-align: center;\">Anaerobic Respiration, Bozeman Science, 2013.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=YbdkbCU20_M\r\n<p style=\"text-align: center;\">Fermentation, The Amoeba Sisters, 2018.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?time_continue=17&amp;v=TVtqwWGguFk&amp;feature=emb_logo\r\n<p style=\"text-align: center;\">Science of Beer: Tapping the Power of Brewer's Yeast, KQED Science, 2014.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n&nbsp;\r\n<h2>Attributions<\/h2>\r\n<strong>Figure 4.11.1<\/strong>\r\n\r\n<a href=\"https:\/\/unsplash.com\/photos\/3R4vPrSB1c4\" rel=\"cc:attributionURL\">Sprinters<\/a> by <a href=\"https:\/\/unsplash.com\/@jon_chng\">Jonathan Chng<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).\r\n\r\n<strong>Figure 4.11.2<\/strong>\r\n\r\n<a href=\"https:\/\/www.ck12.org\/book\/CK-12-College-Human-Biology\/section\/4.11\/\" rel=\"cc:attributionURL\">Alcoholic fermentation<\/a> by Hana Zavadska\/ CK-12 Foundation is used under a <a class=\" dxtrack-user-action Link__LinkItem-sc-15rka1e-0 kxTgHz\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-dx-desc=\"course_modality_image_attribution_license\"><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\">CC BY-NC 3.0<\/span><\/a><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\"> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.\u00a0<\/span>\r\n<div><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\" \/> <span style=\"font-size: 1em;\">\u00a9<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a><\/div>\r\n<div>\r\n<div>Licensed under\u00a0<a href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" \/><\/a>\u00a0\u2022\u00a0<a href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a>\u00a0\u2022\u00a0<a href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/div>\r\n<\/div>\r\n<strong>Figure 4.11.3<\/strong>\r\n\r\n<a href=\"https:\/\/unsplash.com\/photos\/PffLsy3sB4U\" rel=\"cc:attributionURL\">Bread [photo]<\/a> by <a href=\"https:\/\/unsplash.com\/@orlovamaria\">Orlova Maria<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).\r\n\r\n<strong>Figure 4.11.4<\/strong>\r\n\r\n<a href=\"https:\/\/www.ck12.org\/book\/CK-12-College-Human-Biology\/section\/4.11\/\" rel=\"cc:attributionURL\">Lactic Acid Fermenation<\/a> by Hana Zavadska\/ CK-12 Foundation is used under a <a class=\" dxtrack-user-action Link__LinkItem-sc-15rka1e-0 kxTgHz\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-dx-desc=\"course_modality_image_attribution_license\"><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\">CC BY-NC 3.0<\/span><\/a><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\"> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.\u00a0<\/span>\r\n<div><img src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\" \/> <span style=\"font-size: 1em;\">\u00a9<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em;\">Licensed under\u00a0<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" \/><\/a><span style=\"font-size: 1em;\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em;\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/div>\r\n<h2>References<\/h2>\r\n<p class=\"hanging-indent\">Bozeman Science. (2013, May 2). Anaerobic respiration. YouTube. https:\/\/www.youtube.com\/watch?v=cDC29iBxb3w&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">Hana Zavadska\/CK-12 Foundation. (2016, August 15). Figure 2: Alcoholic fermentation\u00a0 [digital image]. In Brainard, J., and Henderson, R., <em>CK-12\u2019s College Human Biology FlexBook\u00ae<\/em> (Section 4.11). CK-12 Foundation. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/4.11\/<\/p>\r\n<p class=\"hanging-indent\">Hana Zavadska\/CK-12 Foundation. (2016, August 15). Figure 4: Lactic acid fermentation [digital image]. In Brainard, J., and Henderson, R., <em>CK-12\u2019s College Human Biology<\/em> FlexBook\u00ae (Section 4.11). CK-12 Foundation. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/4.11\/<\/p>\r\n<p class=\"hanging-indent\">First Nations Health Authority. (2019, September 6). First Nations traditional foods facts Sheet [pdf]. https:\/\/www.fnha.ca\/Documents\/Traditional_Food_Fact_Sheets.pdf<\/p>\r\n<p class=\"hanging-indent\">Genest, M. (2017, May 24)<em>. <\/em>Eulachon, oolichan, hooligan: A fish by any other name is just as oily [online article]. YukonNews.com. https:\/\/www.yukon-news.com\/business\/eulachon-oolichan-hooligan-a-fish-by-any-other-name-is-just-as-oily\/<\/p>\r\n<p class=\"hanging-indent\">KQED Science. (2014, February 11). Science of beer: Tapping the power of brewer's yeast. YouTube. https:\/\/www.youtube.com\/watch?v=TVtqwWGguFk&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2016). The beneficial bacteria that make delicious food - Erez Garty. YouTube. https:\/\/www.youtube.com\/watch?v=eksagPy5tmQ&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">The Amoeba Sisters. (2018, April 30). Fermentation. YouTube. https:\/\/www.youtube.com\/watch?v=YbdkbCU20_M&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 21). Ethanol fuel. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Ethanol_fuel&amp;oldid=963675942<\/p>","rendered":"<p>&nbsp;<\/p>\n<figure id=\"attachment_1825\" aria-describedby=\"caption-attachment-1825\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1825\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Sprinters-e1564874496956-2.jpg\" alt=\"Image shows a photo of women in a short distance running race on a track.\" width=\"400\" height=\"391\" \/><figcaption id=\"caption-attachment-1825\" class=\"wp-caption-text\"><em>Figure 4.11.1 Sprinters racing on a track.\u00a0<\/em><\/figcaption><\/figure>\n<h1>Fast and Furious<\/h1>\n<p>These sprinters&#8217; muscles\u00a0will need a lot of\u00a0energy\u00a0to complete this short race, because they will be running at top\u00a0speed. The action won&#8217;t last long, but it will be very intense. The energy each sprinter needs can&#8217;t be provided quickly enough by aerobic\u00a0cellular respiration. Instead,\u00a0their muscle\u00a0cells must use a\u00a0different process to power their activity.<\/p>\n<div>\n<h1>Making ATP Without Oxygen<\/h1>\n<\/div>\n<p>Living things&#8217;\u00a0cells\u00a0power their activities with the energy-carrying molecule <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5549\">ATP<\/a> (adenosine triphosphate). The\u00a0cells\u00a0of most living things make ATP from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5451\">glucose<\/a> in the process of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5725\">cellular respiration<\/a>. This process occurs in three stages:\u00a0glycolysis, the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1805\">Krebs cycle<\/a>, and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5473\">electron transport<\/a>. The latter two stages require oxygen, making cellular respiration an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1796\">aerobic<\/a> process. When oxygen is not available in cells, the ETS quickly shuts down.\u00a0 Luckily, there are also ways of making ATP from glucose which are\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1826\">anaerobic<\/a>,<\/strong>\u00a0which means that they do not require oxygen. These processes are referred to collectively as\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5617\">anaerobic respiration<\/a><\/strong>.<\/p>\n<div>\n<h1>Fermentation<\/h1>\n<\/div>\n<p>Ome important way of making ATP without oxygen is\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_6003\">fermentation<\/a>.\u00a0<\/strong>Fermentation starts with\u00a0glycolysis, which does not require oxygen, but it does not involve the latter two stages of aerobic cellular respiration (the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1805\">Krebs cycle<\/a>\u00a0and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5473\">electron\u00a0transport<\/a>).\u00a0There are two types of fermentation:\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5879\">alcoholic fermentation<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1830\">lactic\u00a0acid\u00a0fermentation<\/a>. We make use of both types of fermentation\u00a0using other\u00a0organisms, but only lactic\u00a0acid\u00a0fermentation actually takes place inside the\u00a0human body.<\/p>\n<h2>Alcoholic Fermentation<\/h2>\n<figure id=\"attachment_1831\" aria-describedby=\"caption-attachment-1831\" style=\"width: 443px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1831\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/alcoholic-fermentation-2.jpg\" alt=\"\" width=\"443\" height=\"164\" \/><figcaption id=\"caption-attachment-1831\" class=\"wp-caption-text\"><em>Figure 4.11.2 In alcoholic fermentation, pyruvate is converted to ethanol and carbon dioxide.\u00a0 During this process, NAD+ is formed, which allows glycolysis to continue making ATP.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5879\">Alcoholic fermentation<\/a>\u00a0<\/strong>is carried out by single-celled\u00a0fungi\u00a0(called yeasts), as well as some\u00a0bacteria. We use alcoholic fermentation in these organisms to make <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1832\">biofuels<\/a>, bread, and wine. The <a href=\"https:\/\/en.wikipedia.org\/wiki\/Ethanol_fuel\">biofuel ethanol<\/a> (a type of alcohol), for example, is produced by alcoholic fermentation of the glucose in corn or other plants. The process by which this happens is summarized in the diagram\u00a0below. The two pyruvic acid molecules shown in the diagram come from the splitting of glucose in the first stage of the process (glycolysis). ATP is\u00a0also made during\u00a0glycolysis. Two molecules of ATP are produced from each molecule of glucose.<\/p>\n<figure id=\"attachment_1833\" aria-describedby=\"caption-attachment-1833\" style=\"width: 430px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1833\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Bread-e1564876273763-2.jpg\" alt=\"Image shows a close up view of a slice of bread. There are holes in the bread created by bubble of carbon dioxide.\" width=\"430\" height=\"357\" \/><figcaption id=\"caption-attachment-1833\" class=\"wp-caption-text\"><em>Figure 4.11.3 Holes in bread created by carbon dioxide.<\/em><\/figcaption><\/figure>\n<p>Yeasts in bread dough also use alcoholic fermentation for\u00a0energy. They produce carbon dioxide\u00a0gas\u00a0as a waste product. The carbon dioxide released causes bubbles in the dough and explains why the dough rises. Do you see the small holes in the bread pictured\u00a0to the right? The holes were formed by bubbles of carbon dioxide\u00a0gas.<\/p>\n<div>\n<p>As you have probably guessed, yeast is also used in producing alcoholic beverages.\u00a0 When making beer, brewers will add yeast to a mix of barley and hops.\u00a0 In the absence of oxygen, yeast will carry out alcoholic fermentation in order to convert the glucose in the barley into energy, producing the alcohol content as well as the carbonation present in beer.<\/p>\n<p><span style=\"font-size: 1.424em; font-weight: bold;\">Lactic Acid Fermentation<\/span><\/p>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1830\">Lactic acid fermentation<\/a><\/strong>\u00a0is carried out by certain\u00a0bacteria, including the bacteria in yogurt. It is also carried out by your muscle cells when you work them hard and fast. This is how the\u00a0muscles\u00a0of the sprinters pictured\u00a0above\u00a0get\u00a0energy\u00a0for their\u00a0short-lived \u2014\u00a0but intense \u2014 activity. When this happens, your muscles are using ATP faster than your cardiovascular system can deliver oxygen!\u00a0 The process\u00a0by\u00a0which this happens is summarized in the diagram\u00a0below. Again, the two pyruvic acid molecules shown in the diagram come from the splitting of glucose in the first stage of the process (glycolysis). It is also during this stage that two ATP molecules are produced. The rest of the processes produce lactic acid. Note that, unlike in alcoholic fermentation, there is no carbon dioxide waste product in lactic acid fermentation.<\/p>\n<figure id=\"attachment_1908\" aria-describedby=\"caption-attachment-1908\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1908 size-full\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Lactic-Acid-Fermenation-2.jpg\" alt=\"Image shows a diagram of the formula of lactic acid fermentation, in which pyruvic acid is converted into lactic acid.\" width=\"500\" height=\"185\" \/><figcaption id=\"caption-attachment-1908\" class=\"wp-caption-text\"><em>Figure 4.11.4 Lactic acid fermentation formula.<\/em><\/figcaption><\/figure>\n<div>\n<p>Lactic acid fermentation produces lactic acid and NAD+. The NAD+ cycles back to allow glycolysis to continue so more ATP is made. Each circle represents a carbon atom.<\/p>\n<\/div>\n<p>Did you ever run a race, lift heavy weights, or participate in some other intense activity and notice that your\u00a0muscles\u00a0start to feel a burning sensation? This may occur when your muscle cells use lactic acid fermentation to provide ATP for energy. The buildup of lactic acid in the muscles causes\u00a0a burning feeling.\u00a0This painful sensation is useful if it gets you to stop overworking your muscles and allow them a recovery period, during which cells can eliminate the lactic acid.<\/p>\n<div>\n<h1>Pros and Cons of Anaerobic Respiration<\/h1>\n<\/div>\n<p><em>With<\/em> oxygen, organisms can use\u00a0aerobic\u00a0cellular respiration to produce up to 38 molecules of ATP from just one molecule of glucose. <em>Without<\/em> oxygen, organisms must use anaerobic respiration to produce ATP, and this process produces only two molecules of ATP per molecule of glucose. Although anaerobic respiration produces less ATP, it has the advantage of doing so very quickly. For example, it allows your muscles to get the energy they need for short bursts of intense activity. Aerobic cellular respiration, in contrast, produces ATP more slowly.<\/p>\n<h1>Fermentation in Food Production<\/h1>\n<p>Anaerobic respiration is also used in the food industry.\u00a0 You read about yeast&#8217;s role in making bread and beer, but did you know that there are many microbes that are used to create the food we eat, including cheese, sour cream, yogurt, soy sauce, olives, pepperoni, and many more.\u00a0 Watch the video below to learn more about fermentation in the food industry.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"The beneficial bacteria that make delicious food - Erez Garty\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/eksagPy5tmQ?start=3&#38;feature=oembed\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">The beneficial bacteria that make delicious food &#8211; Erez Garty, TED-Ed, 2016.<\/p>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.11 Cultural Connection<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p class=\"textbox__title\" style=\"margin-top: 2.14286em; margin-bottom: 1.42857em; line-height: 1.28571em; color: #ffffff;\"><span style=\"color: #000000;\">Fishing has always been part of the culture and nutrition of Indigenous peoples living on the west coast of Canada.\u00a0 Fish provides delicious important nutrients such as protein, Omega-3 fatty acids, calcium, iron, and Vitamins A, B, C and D.\u00a0 Traditionally, no part of the fish was wasted, including head, eyes, internal organs, and eggs.<\/span><\/p>\n<p>Eulachon, also known as candle fish or oolichan, (pictured below) have been prized for their oil for thousands of years. The pathways of these fish dictated &#8220;grease trails&#8221; and are found from Bristol Bay, Alaska, all the way south to the Klamath River, California.\u00a0 Within BC, the areas of Nass, Knights Inlet, and Bella Coola had large trading centres for this important natural resource.<\/p>\n<div id=\"h5p-480\">\n<div class=\"h5p-content\" data-content-id=\"480\"><\/div>\n<\/div>\n<p>Photos by Brodie Guy &#8211; <a href=\"https:\/\/brodieguy.com\/\">www.brodieguy.com<\/a> <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/\">CC BY-NC-ND 4.0<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Euchalon were and are eaten fresh, smoked or dried, and as grease.\u00a0 The grease remains a highly valued food to Indigenous coastal communities.\u00a0 The flavour of the grease varies greatly depending not only on where the fish is from and how it is made, but also how long it is left to ferment.\u00a0 To ferment the eulachon, fish are left in a wood-lined locker dug into the soil for 10 days.\u00a0 Fermentation uses the action of fungi and bacteria to break down the fish making oil extraction much faster and easier.<\/p>\n<p>To learn more, visit the <a href=\"https:\/\/www.fnha.ca\/Documents\/Traditional_Food_Fact_Sheets.pdf\">First Nations Health Authority Traditional Foods Fact Sheet<\/a> and a feature in the Yukon News, <a href=\"https:\/\/www.yukon-news.com\/business\/eulachon-oolichan-hooligan-a-fish-by-any-other-name-is-just-as-oily\/\">&#8220;Eulachon, oolicahn, hooligan: A fish by any other name is just as oily.&#8221;<\/a><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.11 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The cells of most living things produce <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5549\">ATP<\/a> from glucose by aerobic cellular respiration, which uses oxygen. Some organisms instead produce ATP from glucose by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5617\">anaerobic respiration<\/a>, which does not require oxygen.<\/li>\n<li>An important way of making ATP without oxygen is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_6003\">fermentation<\/a>. There are two types of fermentation: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_5879\">alcoholic fermentation<\/a> and lactic acid fermentation. Both start with glycolysis, the first (anaerobic) stage of cellular respiration, in which two molecules of ATP are produced from one molecule of glucose.<\/li>\n<li>Alcoholic fermentation is carried out by single-celled organisms, including yeasts and some\u00a0bacteria. We use alcoholic fermentation in these organisms to make biofuels, bread, and wine.<\/li>\n<li>Lactic acid fermentation is undertaken by certain bacteria, including the bacteria in yogurt, and also by our muscle cells when they are worked hard and fast.<\/li>\n<li>Anaerobic respiration produces <em>far<\/em> less ATP than does aerobic cellular respiration, but it has the advantage of being much faster. For example, it allows muscles to get the energy they need for short bursts of intense activity.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.11 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Explain\u00a0the primary\u00a0difference between aerobic cellular respiration and anaerobic respiration.<\/li>\n<li>What is fermentation?<\/li>\n<li>Compare and contrast alcoholic and lactic acid fermentation.<\/li>\n<li>Identify the major pros and the major cons of anaerobic respiration relative to aerobic cellular respiration.<\/li>\n<li>What process is shared between aerobic cellular respiration and anaerobic respiration? Describe the process briefly. Why can this process happen in anaerobic respiration, as well as aerobic respiration?<\/li>\n<li>\n<div id=\"h5p-481\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-481\" class=\"h5p-iframe\" data-content-id=\"481\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Fermentation\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What is the reactant (or starting material)common to\u00a0aerobic respiration and both types of fermentation?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.11 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"Anaerobic Respiration\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/cDC29iBxb3w?start=3&#38;feature=oembed\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Anaerobic Respiration, Bozeman Science, 2013.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-3\" title=\"Fermentation\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/YbdkbCU20_M?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Fermentation, The Amoeba Sisters, 2018.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-4\" title=\"Science of Beer: Tapping the Power of Brewer&#39;s Yeast\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/TVtqwWGguFk?start=17&#38;feature=oembed\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Science of Beer: Tapping the Power of Brewer&#8217;s Yeast, KQED Science, 2014.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.11.1<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/3R4vPrSB1c4\" rel=\"cc:attributionURL\">Sprinters<\/a> by <a href=\"https:\/\/unsplash.com\/@jon_chng\">Jonathan Chng<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 4.11.2<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/CK-12-College-Human-Biology\/section\/4.11\/\" rel=\"cc:attributionURL\">Alcoholic fermentation<\/a> by Hana Zavadska\/ CK-12 Foundation is used under a <a class=\"dxtrack-user-action Link__LinkItem-sc-15rka1e-0 kxTgHz\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-dx-desc=\"course_modality_image_attribution_license\"><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\">CC BY-NC 3.0<\/span><\/a><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\"> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.\u00a0<\/span><\/p>\n<div><img decoding=\"async\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\" \/> <span style=\"font-size: 1em;\">\u00a9<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a><\/div>\n<div>\n<div>Licensed under\u00a0<a href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img decoding=\"async\" class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" \/><\/a>\u00a0\u2022\u00a0<a href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a>\u00a0\u2022\u00a0<a href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/div>\n<\/div>\n<p><strong>Figure 4.11.3<\/strong><\/p>\n<p><a href=\"https:\/\/unsplash.com\/photos\/PffLsy3sB4U\" rel=\"cc:attributionURL\">Bread [photo]<\/a> by <a href=\"https:\/\/unsplash.com\/@orlovamaria\">Orlova Maria<\/a> on <a href=\"https:\/\/unsplash.com\/\">Unsplash<\/a> is used under the <a class=\"ICezk _2GAZm _2WvKc\" href=\"https:\/\/unsplash.com\/license\">Unsplash License<\/a> (https:\/\/unsplash.com\/license).<\/p>\n<p><strong>Figure 4.11.4<\/strong><\/p>\n<p><a href=\"https:\/\/www.ck12.org\/book\/CK-12-College-Human-Biology\/section\/4.11\/\" rel=\"cc:attributionURL\">Lactic Acid Fermenation<\/a> by Hana Zavadska\/ CK-12 Foundation is used under a <a class=\"dxtrack-user-action Link__LinkItem-sc-15rka1e-0 kxTgHz\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-dx-desc=\"course_modality_image_attribution_license\"><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\">CC BY-NC 3.0<\/span><\/a><span class=\"ImageAttribution__Value-sc-133gw9p-5 gaNGPC\"> (https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) license.\u00a0<\/span><\/p>\n<div><img decoding=\"async\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/logo_ck12.png\" alt=\"\" \/> <span style=\"font-size: 1em;\">\u00a9<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/www.ck12.org\/\">CK-12 Foundation<\/a> <span style=\"font-size: 1em;\">Licensed under\u00a0<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/\"><img decoding=\"async\" class=\"alignnone size-full wp-image-8217\" title=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" src=\"https:\/\/www.ck12info.org\/wp-content\/uploads\/2016\/05\/icon_licence.png\" alt=\"CK-12 Foundation is licensed under Creative Commons AttributionNonCommercial 3.0 Unported (CC BY-NC 3.0)\" \/><\/a><span style=\"font-size: 1em;\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/www.ck12.org\/about\/terms-of-use\/\">Terms of Use<\/a><span style=\"font-size: 1em;\">\u00a0\u2022\u00a0<\/span><a style=\"font-size: 1em;\" href=\"http:\/\/www.ck12.org\/about\/attribution\/\">Attribution<\/a><\/div>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Bozeman Science. (2013, May 2). Anaerobic respiration. YouTube. https:\/\/www.youtube.com\/watch?v=cDC29iBxb3w&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Hana Zavadska\/CK-12 Foundation. (2016, August 15). Figure 2: Alcoholic fermentation\u00a0 [digital image]. In Brainard, J., and Henderson, R., <em>CK-12\u2019s College Human Biology FlexBook\u00ae<\/em> (Section 4.11). CK-12 Foundation. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/4.11\/<\/p>\n<p class=\"hanging-indent\">Hana Zavadska\/CK-12 Foundation. (2016, August 15). Figure 4: Lactic acid fermentation [digital image]. In Brainard, J., and Henderson, R., <em>CK-12\u2019s College Human Biology<\/em> FlexBook\u00ae (Section 4.11). CK-12 Foundation. https:\/\/www.ck12.org\/book\/ck-12-college-human-biology\/section\/4.11\/<\/p>\n<p class=\"hanging-indent\">First Nations Health Authority. (2019, September 6). First Nations traditional foods facts Sheet [pdf]. https:\/\/www.fnha.ca\/Documents\/Traditional_Food_Fact_Sheets.pdf<\/p>\n<p class=\"hanging-indent\">Genest, M. (2017, May 24)<em>. <\/em>Eulachon, oolichan, hooligan: A fish by any other name is just as oily [online article]. YukonNews.com. https:\/\/www.yukon-news.com\/business\/eulachon-oolichan-hooligan-a-fish-by-any-other-name-is-just-as-oily\/<\/p>\n<p class=\"hanging-indent\">KQED Science. (2014, February 11). Science of beer: Tapping the power of brewer&#8217;s yeast. YouTube. https:\/\/www.youtube.com\/watch?v=TVtqwWGguFk&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2016). The beneficial bacteria that make delicious food &#8211; Erez Garty. YouTube. https:\/\/www.youtube.com\/watch?v=eksagPy5tmQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">The Amoeba Sisters. (2018, April 30). Fermentation. YouTube. https:\/\/www.youtube.com\/watch?v=YbdkbCU20_M&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Wikipedia contributors. (2020, June 21). Ethanol fuel. In\u00a0<i>Wikipedia. <\/i>\u00a0https:\/\/en.wikipedia.org\/w\/index.php?title=Ethanol_fuel&amp;oldid=963675942<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4478_5549\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_5549\"><div tabindex=\"-1\"><p>A complex organic chemical that provides energy to drive many processes in living cells, e.g. muscle contraction, nerve impulse propagation, and chemical synthesis. Found in all forms of life, ATP is often referred to as the \"molecular unit of currency\" of intracellular energy transfer.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_5451\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_5451\"><div tabindex=\"-1\"><p>Glucose (also called dextrose) is a simple sugar with the molecular formula C6H12O6. Glucose is the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, using energy from sunlight.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_5725\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_5725\"><div tabindex=\"-1\"><p>A set of metabolic reactions and processes that take place in the cells of organisms to convert biochemical energy from nutrients into adenosine triphosphate (ATP).<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_1798\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_1798\"><div tabindex=\"-1\"><\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_1805\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_1805\"><div tabindex=\"-1\"><p>Image shows a four-tier diagram in a 28 day timeline of the menstruation cycle.  The  first tier shows basal body temperature (BBT) over the 28 days.  BBT is about 1 degree celcius lower before ovulation than after.  The next tier shows relative levels of follicle stimulating hormone (FSH), leutenizing hormone (LH), estrogen and progesterone.  At the time of ovulation, levels of FSH, LH and estrogen spike and then drop off.  Progesterone increases after ovulation and then drops off close to day 25.<br \/>\nIn the third tier is a representation of changes to the follicle and corpus luteum during the ovarian cycle.  In the first 14 days of the cycle, the follicle is growing.  On day 14, the follicle ejects the ovum and starts converting to a corpus lutem, which persists from day 15-28, at which point it has degenerated.<br \/>\nIn the fourth tier, the uterine cycle is illustrated, showing relative thickness of the endometrium.  On days 1-5 menses rids the body of broken down endometrial tissue from the last cycle.  Day 6-14 the endometrium thickens and develops, and then day 15 the endometrium is maintained.  If fertilization and implantation do no occur, the endometrium begins to break down towards the end of the secretory phase.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_5473\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_5473\"><div tabindex=\"-1\"><p>A series of electron transporters embedded in the inner mitochondrial membrane that shuttles electrons from NADH and FADH2 to molecular oxygen. In the process, protons are pumped from the mitochondrial matrix to the intermembrane space, and oxygen is reduced to form water.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_1796\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_1796\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_3498\" aria-describedby=\"caption-attachment-3498\" style=\"width: 409px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-3498\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Insulin_Application-1.jpg\" alt=\"9.7.1 Blood glucose testing\" width=\"409\" height=\"435\"><figcaption id=\"caption-attachment-3498\" class=\"wp-caption-text\"><em>Figure 9.7.1 Got to keep the balance.<\/em><\/figcaption><\/figure>\n<div>\n<h1>A Shot in the Arm<\/h1>\n<\/div>\n<p>Giving yourself an injection can be difficult, but for someone with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2969\">diabetes<\/a>, it may be a matter of life or death. The person in the photo has diabetes and is injecting themselves with insulin, the hormone that helps control the level of glucose in the blood. Insulin is produced by the pancreas.<\/p>\n<div>\n<h1>Introduction to the Pancreas<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3197\">pancreas<\/a><\/strong> is a large gland located in the upper left abdomen behind the stomach, as shown in Figure 9.7.2. The pancreas is about 15 cm (6 in) long, and it has a flat, oblong shape. Structurally, the pancreas is divided into a head, body, and tail. Functionally, the pancreas serves as both an endocrine gland and an exocrine gland.<\/p>\n<ul>\n<li>As an endocrine gland, the pancreas is part of the endocrine system. As such, it releases hormones (such as insulin) directly into the bloodstream for transport to cells throughout the body.<\/li>\n<li>As an exocrine gland, the pancreas is part of the digestive system. As such, it releases digestive enzymes into ducts that carry the enzymes to the gastrointestinal tract, where they assist with digestion. In this concept, the focus is on the pancreas as an endocrine gland. You can read about the pancreas as an exocrine gland in <a href=\"http:\/\/humanbiology.pressbooks.tru.ca\/chapter\/17-6-accessory-organs-of-digestion\/\">Chapter 15 Digestive System.<\/a><\/li>\n<\/ul>\n<figure id=\"attachment_3499\" aria-describedby=\"caption-attachment-3499\" style=\"width: 2047px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-3499\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0699_PancreasAnatomy2-1.png\" alt=\"Location of the pancreas\" width=\"2047\" height=\"1638\"><figcaption id=\"caption-attachment-3499\" class=\"wp-caption-text\"><em>Figure 9.7.2 The pancreas is located behind the stomach and near the upper part of the small intestine (duodenum). Its ducts carry digestive enzymes into the small intestine. The endocrine hormones it produces are secreted into the blood.<\/em><\/figcaption><\/figure>\n<div>\n<h1>The Pancreas as an Endocrine Gland<\/h1>\n<\/div>\n<p>The tissues within the pancreas that have an endocrine role exist as clusters of cells called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3500\">pancreatic islets<\/a>.<\/strong> They are also called the islets of Langerhans. You can see pancreatic tissue, including islets, in Figure 9.7.3. There are approximately three million pancreatic islets, and they are crisscrossed by a dense network of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3501\">capillaries<\/a>. The capillaries are lined by layers of islet cells that have direct contact with the blood vessels, into which they secrete their endocrine hormones.<\/p>\n<figure id=\"attachment_3502\" aria-describedby=\"caption-attachment-3502\" style=\"width: 637px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-3502\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Exocrine_and_Endocrine_Pancreas-1.jpg\" alt=\"Pancreas: Endocrine and Exocrine Gland\" width=\"637\" height=\"827\"><figcaption id=\"caption-attachment-3502\" class=\"wp-caption-text\"><em>Figure 9.7.3 The anatomy of the pancreas. The inset diagram shows pancreatic islet cells that produce endocrine hormones. It also shows the cells (called acinar cells) that secrete exocrine substances involved in digestion into pancreatic ducts.<\/em><\/figcaption><\/figure>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<p>The pancreatic islets consist of four main types of cells, each of which secretes a different endocrine hormone.\u00a0All of the hormones produced by the pancreatic islets, however, play crucial roles in <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_317\">glucose<\/a> <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_176\">metabolism<\/a> and the regulation of blood glucose levels, among other functions.<\/p>\n<ol>\n<li>Islet cells called alpha (\u03b1) cells secrete the hormone <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3405\">glucagon<\/a>. The function of glucagon is to increase the level of glucose in the blood. It does this by stimulating the liver to convert stored glycogen into glucose, which is released into the bloodstream.<\/li>\n<li>Islets cells called beta (\u03b2) cells secrete the hormone <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2590\">insulin<\/a>. The function of insulin is to decrease the level of glucose in the blood. It does this by promoting the absorption of glucose from the blood into fat, liver, and skeletal muscle cells. In these tissues, the absorbed glucose is converted into glycogen, fats (triglycerides), or both.<\/li>\n<li>Islet cells called delta (\u03b4) cells secrete the hormone\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3503\">somatostatin<\/a>.<\/strong>\u00a0This hormone is also called growth hormone inhibiting hormone, because it inhibits the anterior lobe of the pituitary gland from producing growth hormone. Somatostatin also inhibits the secretion of pancreatic endocrine hormones and pancreatic exocrine enzymes.<\/li>\n<li>Islet cells called gamma (\u03b3) cells secrete the hormone <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3504\">pancreatic polypeptide<\/a>. The function of pancreatic polypeptide is to help regulate the secretion of both endocrine and exocrine substances by the pancreas.<\/li>\n<\/ol>\n<div>\n<h1>Disorders of the Pancreas<\/h1>\n<\/div>\n<p>There are a variety of disorders that affect the pancreas. They include pancreatitis, pancreatic cancer, and diabetes mellitus.<\/p>\n<h2>Pancreatitis<\/h2>\n<figure id=\"attachment_3506\" aria-describedby=\"caption-attachment-3506\" style=\"width: 390px\" class=\"wp-caption alignright\"><img class=\" wp-image-3506\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Jaundice_eye_new-1.jpg\" alt=\"Jaundice due to Pancreatitis\" width=\"390\" height=\"165\"><figcaption id=\"caption-attachment-3506\" class=\"wp-caption-text\"><em>Figure 9.7.4 Jaundice, or yellowing of the skin and whites of the eyes, is a common sign of pancreatitis.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3505\">Pancreatitis<\/a><\/strong> is inflammation of the pancreas. It has a variety of possible causes, including gallstones, chronic alcohol use, infections (such as measles or mumps), and certain medications. Pancreatitis occurs when digestive enzymes produced by the pancreas damage the gland\u2019s tissues, which causes problems with fat digestion. The disorder is usually associated with intense pain in the central abdomen, and the pain may radiate to the back. Yellowing of the skin and whites of the eyes (see Figure 9.7.4), which is called jaundice, is a common sign of pancreatitis. People with pancreatitis may also have pale stools and dark urine. Treatment of pancreatitis includes administering drugs to manage pain, and addressing the underlying cause of the disease, for example, by removing gallstones.<\/p>\n<h2>Pancreatic Cancer<\/h2>\n<p>There are several different types of pancreatic cancer that may affect either the endocrine or the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3398\">exocrine<\/a> tissues of the gland. Cancers affecting the endocrine tissues are all relatively rare. However, their incidence has been rising sharply. It is unclear to what extent this reflects increased detection, especially through medical imaging techniques. Unfortunately, pancreatic cancer is usually diagnosed at a relatively late stage when it is too late for surgery, which is the only way to cure the disorder. In 2020 it is estimated that 6,000 Canadians will be newly diagnosed with pancreatic cancer, and that during this same year, 5,300 will die of pancreatic cancer.<\/p>\n<p>While it is rare before the age of 40, pancreatic cancer occurs most often after the age of 60. Factors that increase the risk of developing pancreatic cancer include smoking, obesity, diabetes, and a family history of the disease. About one in four cases of pancreatic cancer are attributable to smoking. Certain rare genetic conditions are also risk factors for pancreatic cancer.<\/p>\n<h2>Diabetes Mellitus<\/h2>\n<p>By far the most common type of pancreatic disorder is <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2771\">diabetes mellitus<\/a>, more commonly called simply diabetes. There are many different types of diabetes, but diabetes mellitus is the most common. It occurs in two major types, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3507\">type 1 diabetes<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2970\">type 2 diabetes<\/a>. The two types have different causes and may also have different treatments, but they generally produce the same initial symptoms, which include excessive urination and thirst. These symptoms occur because the kidneys excrete more urine in an attempt to rid the blood of excess glucose. Loss of water in urine stimulates greater thirst. Other signs and symptoms of diabetes are listed in Figure 9.7.5.<\/p>\n<figure id=\"attachment_3508\" aria-describedby=\"caption-attachment-3508\" style=\"width: 738px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-3508\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Main_symptoms_of_diabetes.svg_-1.png\" alt=\"Symptoms of Diabetes\" width=\"738\" height=\"755\"><figcaption id=\"caption-attachment-3508\" class=\"wp-caption-text\"><em>Figure 9.7.5 This chart shows symptoms shared by both type 1 and type 2 diabetes in black and symptoms more common in type 1 diabetes in blue.<\/em><\/figcaption><\/figure>\n<p>When diabetes is not well controlled, it is likely to have several serious long-term consequences. Most of these consequences are due to damage to small blood vessels caused by high <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_317\">glucose<\/a> levels in the blood. Damage to blood vessels, in turn, may lead to increased risk of coronary artery disease and stroke. Damage to blood vessels in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3139\">retina<\/a> of the eye can result in gradual vision loss and blindness. Damage to blood vessels in the kidneys can lead to chronic kidney disease, sometimes requiring dialysis or kidney transplant. Long-term consequences of diabetes may also include damage to the nerves of the body, known as diabetic neuropathy. In fact, this is the most common complication of diabetes. Symptoms of diabetic neuropathy may include numbness, tingling, and pain in the extremities.<\/p>\n<h3>Type 1 Diabetes<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3507\">Type 1 diabetes<\/a><\/strong>\u00a0is a chronic autoimmune disorder in which the immune system attacks the insulin-secreting beta cells of the pancreas. As a result, people with type 1 diabetes lack the insulin needed to keep blood glucose levels within the normal range. Type 1 diabetes may develop in people of any age, but is most often diagnosed before adulthood. For type 1 diabetics, insulin injections are critical for survival.<\/p>\n<h3>Type 2 Diabetes<\/h3>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2970\">Type 2 diabetes<\/a><\/strong>\u00a0is the single most common form of diabetes. The cause of high blood glucose in this form of diabetes usually includes a combination of insulin resistance and impaired insulin secretion. Both genetic and environmental factors play roles in the development of type 2 diabetes.\u00a0Type 2 diabetes can be managed with\u00a0changes in diet and physical activity, which may increase insulin sensitivity and help reduce blood glucose levels to normal ranges. Medications may also be used as part of the treatment, as may insulin injections.<\/p>\n<div>\n<h1>Feature: Human Biology in the News<\/h1>\n<\/div>\n<p>Some patients with type 1 diabetes have been given pancreatic islet cells transplants from other human donors. If the transplanted cells are not rejected by the recipient\u2019s immune system, they can cure the patient of diabetes. However,\u00a0because of a shortage of appropriate human donors, only about\u00a0one thousand\u00a0such surgeries have been performed over the past ten years.<\/p>\n<p>In June of 2016, a research team led by Dr. David K.C. Cooper at the Thomas E. Starzl Transplantation Institute in Pittsburgh, Pennsylvania, reported on their work developing pig islet cells for transplant into human diabetes patients. The researchers genetically engineered the pig islet cells to be protected from the human immune response. As a result, patients receiving the transplanted cells would require only minimal suppression of their immune system after the surgery. The pig islet cells would also be less likely to transmit pathogenic agents, because the animals could be raised in a controlled environment.<\/p>\n<p>The researchers have successfully transplanted the pig islet cells into monkey models of type 1 diabetes. As of June 2016, the scientists were looking for funding to undertake clinical trials in humans with type 1 diabetes. Dr. Cooper predicted then that if the human trials go as well as expected, the pig islet cells could be available for curing patients in as little as two years.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">9.7 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3197\">pancreas<\/a> is a gland located in the upper left abdomen behind the stomach that functions as both an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2939\">endocrine gland<\/a> and an <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3398\">exocrine gland<\/a>. As an endocrine gland, the pancreas releases hormones (such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2590\">insulin<\/a>) directly into the bloodstream. As an exocrine gland, the pancreas releases digestive enzymes into ducts that carry them to the gastrointestinal tract.<\/li>\n<li>Tissues in the pancreas that have an endocrine role exist as clusters of cells called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3500\">pancreatic islets<\/a>. The islets consist of four main types of cells, each of which secretes a different endocrine hormone. Alpha (\u03b1) cells secrete <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3405\">glucagon<\/a>, beta (\u03b2) cells secrete insulin, delta (\u03b4) cells secrete <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3503\">somatostatin<\/a>, and gamma (\u03b3) cells secrete <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3504\">pancreatic polypeptide<\/a>.<\/li>\n<li>The endocrine hormones secreted by the pancreatic islets all play a role, either directly or indirectly, in glucose metabolism and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_173\">homeostasis<\/a> of blood glucose levels. For example, insulin stimulates the uptake of glucose by cells and decreases the level of glucose in the blood, whereas glucagon stimulates the conversion of glycogen to glucose and increases the level of glucose in the blood.<\/li>\n<li>Disorders of the pancreas include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3505\">pancreatitis<\/a>, pancreatic <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1600\">cancer<\/a>, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2771\">diabetes mellitus<\/a>. Pancreatitis is painful inflammation of the pancreas that has many possible causes. Pancreatic cancer of the endocrine tissues is rare, but increasing in frequency. It is generally discovered too late to cure surgically. Smoking is a major risk factor for pancreatic cancer.<\/li>\n<li>Diabetes mellitus is the most common type of pancreatic disorder. In diabetes, inadequate\u00a0activity\u00a0of insulin results in high blood levels of glucose. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3507\">Type 1 diabetes<\/a> is a chronic autoimmune disorder in which the immune system attacks the insulin-secreting beta cells of the pancreas. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2970\">Type 2 diabetes<\/a> is usually caused by a combination of insulin resistance and impaired insulin secretion due to a variety of environmental and genetic factors.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">9.7 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Describe the structure and location of the pancreas.<\/li>\n<li>Distinguish between the endocrine and exocrine functions of the pancreas.<\/li>\n<li>\n<div id=\"h5p-139\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-139\" class=\"h5p-iframe\" data-content-id=\"139\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Label the brain\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>\n<div id=\"h5p-140\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-140\" class=\"h5p-iframe\" data-content-id=\"140\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Brain\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>What is pancreatitis? What are possible causes and effects of pancreatitis?<\/li>\n<li>Describe the incidence, prognosis, and risk factors of cancer of the endocrine tissues of the pancreas.<\/li>\n<li>Compare and contrast type 1 and type 2 diabetes.<\/li>\n<li>If the alpha islet cells of the pancreas were damaged to the point that they no longer functioned, how would this affect blood glucose levels? Assume that no outside regulation of this system is occurring and explain your answer. Further, would administration of insulin be more likely to help or hurt\u00a0this condition? Explain your answer.<\/li>\n<li>Explain why diabetes causes excessive thirst.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">9.7 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=8dgoeYPoE-0&amp;t=2s<\/p>\n<p style=\"text-align: center\">What does the pancreas do? - Emma Bryce, TED-Ed, 2015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=qlzLSbAGMqA&amp;feature=emb_logo<\/p>\n<p style=\"text-align: center\">Type 2 diabetes in children, Children's Health, 2008.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=da1vvigy5tQ<\/p>\n<p style=\"text-align: center\">Reversing Type 2 diabetes starts with ignoring the guidelines | Sarah Hallberg | TEDxPurdueU, TEDx Talks, 2015.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 9.7.1<\/strong><\/p>\n<section class=\"standard post-785 chapter type-chapter status-publish hentry focusable\" data-type=\"chapter\">\n<div class=\"media-atttributions\">\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Insulin_Application.jpg\" rel=\"cc:attributionURL\">Insulin_Application<\/a> by <a class=\"extiw\" title=\"w:cs:User:Mr Hyde\" href=\"https:\/\/en.wikipedia.org\/wiki\/cs:User:Mr_Hyde\">Mr Hyde<\/a>\u00a0at\u00a0<a class=\"extiw\" title=\"w:cs:\" href=\"https:\/\/en.wikipedia.org\/wiki\/cs:\">Czech Wikipedia<\/a> (Original text: moje foto) on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain)<i>.<\/i><\/p>\n<p><strong>Figure 9.7.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0699_PancreasAnatomy2.png\" rel=\"cc:attributionURL\">Blausen_0699_PancreasAnatomy2<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a\u00a0 <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 9.7.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2424_Exocrine_and_Endocrine_Pancreas.jpg\" rel=\"cc:attributionURL\">Exocrine_and_Endocrine_Pancreas<\/a>\u00a0by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/23-6-accessory-organs-in-digestion-the-liver-pancreas-and-gallbladder\">OpenStax College<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0 <\/a>(https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en) license.<\/p>\n<p><strong>Figure 9.7.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Jaundice_eye_new.jpg\" rel=\"cc:attributionURL\">Jaundice_eye_new<\/a> by <a class=\"mw-userlink\" title=\"User:Info-farmer\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Info-farmer\">Info-farmer<\/a> on Wikimedia Commons is in the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain)<i>.<\/i>\u00a0(Original image, File:<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Jaundice_eye.jpg\">Jaundice eye.jpg<\/a>, is from <a class=\"extiw\" title=\"w:Centers for Disease Control and Prevention\" href=\"https:\/\/en.wikipedia.org\/wiki\/Centers_for_Disease_Control_and_Prevention\">Centers for Disease Control and Prevention<\/a>'s\u00a0<a class=\"external text\" href=\"https:\/\/phil.cdc.gov\/\" rel=\"nofollow\">Public Health Image Library<\/a>\u00a0(PHIL), with identification number\u00a0<b><a class=\"external text\" href=\"https:\/\/phil.cdc.gov\/details.aspx?pid=2860\" rel=\"nofollow\">#2860<\/a><\/b><a class=\"external text\" href=\"https:\/\/phil.cdc.gov\/details.aspx?pid=2860\" rel=\"nofollow\">)<\/a><\/p>\n<p><strong>Figure 9.7.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Main_symptoms_of_diabetes.svg\" rel=\"cc:attributionURL\">Main_symptoms_of_diabetes.svg<\/a> by <a class=\"extiw\" title=\"en:User:Mikael H\u00e4ggstr\u00f6m\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:Mikael_H%C3%A4ggstr%C3%B6m\">Mikael H\u00e4ggstr\u00f6m<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain)<i>.<\/i><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"glossary\"><span style=\"font-size: 1.424em;font-weight: bold;color: #333333\">References<\/span><\/div>\n<\/section>\n<p class=\"hanging-indent\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, July 19). Figure 23.26 Exocrine and endocrine pancreas [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 23.6). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/23-6-accessory-organs-in-digestion-the-liver-pancreas-and-gallbladder<\/p>\n<p class=\"hanging-indent\">Blausen.com Staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">Children's Health. (2008, June 13). Type 2 diabetes in children. YouTube. https:\/\/www.youtube.com\/watch?v=qlzLSbAGMqA&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\"><span class=\"author\">Hering, B. J.<\/span>,\u00a0<span class=\"author\">Cozzi, E.<\/span>,\u00a0<span class=\"author\">Spizzo, T.<\/span>,\u00a0<span class=\"author\">Cowan, P. J.<\/span>,\u00a0<span class=\"author\">Rayat, G. R.<\/span>,\u00a0<span class=\"author\">Cooper, D. K. C.<\/span>,\u00a0<span class=\"author\">Denner, J<\/span>. (2016, March 4). <span class=\"articleTitle\">First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes\u2014Executive summary<\/span>.\u00a0<i>Xenotransplantation<\/i>\u00a0<em><span class=\"pubYear\">2016<\/span><\/em>, <span class=\"vol\">23<\/span>:\u00a0<span class=\"pageFirst\">3<\/span>\u2013\u00a0<span class=\"pageLast\">13<\/span>. https:\/\/doi.org\/10.1111\/xen.12231<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2015, February 19). What does the pancreas do? - Emma Bryce. YouTube. https:\/\/www.youtube.com\/watch?v=8dgoeYPoE-0&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TEDx Talks. (2015, May 4).\u00a0Reversing Type 2 diabetes starts with ignoring the guidelines | Sarah Hallberg | TEDxPurdueU. YouTube. https:\/\/www.youtube.com\/watch?v=da1vvigy5tQ&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_1826\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_1826\"><div tabindex=\"-1\"><p>Image shows a scraped knee.  It is bleeding slightly.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_5617\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_5617\"><div tabindex=\"-1\"><p>Respiration using electron acceptors other than molecular oxygen. Although oxygen is not the final electron acceptor, the process still uses a respiratory electron transport chain.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_6003\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_6003\"><div tabindex=\"-1\"><p>A metabolic process that produces chemical changes in organic substrates through the action of enzymes. In biochemistry, it is narrowly defined as the extraction of energy from carbohydrates in the absence of oxygen.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_5879\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_5879\"><div tabindex=\"-1\"><p>A biological process which converts sugars such as glucose, fructose, and sucrose into cellular energy, producing ethanol and carbon dioxide as by-products.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_1830\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_1830\"><div tabindex=\"-1\"><p>Image shows a pictomicrograph of staphylococcus.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4478_1832\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4478_1832\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_3535\" aria-describedby=\"caption-attachment-3535\" style=\"width: 350px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-3535\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Sunburn-1.jpg\" alt=\"10.3.1\" width=\"350\" height=\"452\"><figcaption id=\"caption-attachment-3535\" class=\"wp-caption-text\"><em>Figure 10.3.1 Feel the burn!<\/em><\/figcaption><\/figure>\n<h1>Feel the Burn<\/h1>\n<p>The person in Figure 10.3.1 is no doubt feeling the burn \u2014 sunburn, that is. <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3536\">Sunburn<\/a><\/strong>\u00a0occurs when the outer layer of the skin is damaged by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3537\">UV light<\/a> from the\u00a0sun\u00a0or tanning lamps. Some people deliberately allow UV light to burn their skin, because after the redness subsides, they are left with a tan. A tan may look healthy, but it is actually a sign of skin damage. People who experience one or more serious sunburns are significantly more likely to develop\u00a0skin <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3513\">cancer<\/a>. Natural pigment molecules in the skin help protect it from UV light damage. These pigment molecules are found in the layer of the skin called the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3899\">epidermis<\/a>.<\/p>\n<div>\n<h1>What is the\u00a0Epidermis?<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3899\">epidermis<\/a><\/strong>\u00a0is the outer of the two main layers of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3521\">skin<\/a>. The inner layer\u00a0is\u00a0the\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3875\">dermis<\/a>. It averages about 0.10 mm thick, and is much thinner than the dermis. The epidermis is thinnest on the eyelids (0.05 mm) and thickest on the palms of the hands and soles of the feet (1.50 mm). The epidermis covers almost the entire body surface. It is continuous with \u2014 but structurally distinct from \u2014 the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3538\">mucous membranes<\/a>\u00a0that line the mouth, anus, urethra, and vagina.<\/p>\n<div>\n<h1>Structure of the Epidermis<\/h1>\n<\/div>\n<p>There are no blood vessels and very few nerve cells in the epidermis. Without blood to bring epidermal cells oxygen and nutrients, the cells must absorb oxygen directly from the air and obtain nutrients via <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_1655\">diffusion<\/a> of fluids from the dermis below. However, as thin as it is, the epidermis still has a complex structure. It has a variety of cell types and multiple layers.<\/p>\n<h2>Cells\u00a0of the Epidermis<\/h2>\n<p>There are several different types of\u00a0cells\u00a0in the epidermis. All of the cells are necessary for the important functions of the epidermis.<\/p>\n<ul>\n<li>The epidermis consists mainly of stacks of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3525\">keratin<\/a>-producing epithelial cells called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3524\">keratinocytes<\/a><\/strong>. These cells make up at least 90 per cent of the epidermis. Near the top of the epidermis, these cells are also called squamous cells.<\/li>\n<li>Another eight per cent of epidermal cells are <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3526\">melanocytes<\/a><\/strong>. These cells produce the pigment melanin that protects the\u00a0dermis\u00a0from UV light.<\/li>\n<li>About one per cent of epidermal cells are <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3540\">Langerhans cells<\/a><\/strong>. These are immune system cells that detect and fight pathogens entering the skin.<\/li>\n<li>Less than one per cent of epidermal cells are <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3527\">Merkel cells<\/a><\/strong>, which respond to light touch and connect to nerve endings in the dermis.<\/li>\n<\/ul>\n<h2>Layers of the Epidermis<\/h2>\n<p>The epidermis in most parts of the body consists of four distinct layers. A fifth layer occurs in the palms of the hands and soles of the feet, where the epidermis is thicker than in the rest of the body. The layers of the epidermis are shown in Figure 10.3.2, and described in the following text.<\/p>\n<figure id=\"attachment_3541\" aria-describedby=\"caption-attachment-3541\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-3541\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Blausen_0353_Epidermis-1.png\" alt=\"Diagram of the Epidermis\" width=\"1024\" height=\"1024\"><figcaption id=\"caption-attachment-3541\" class=\"wp-caption-text\"><em>Figure 10.3.2 The epidermis has multiple layers, and structures (such as hairs from the dermis below it) pass through them. This diagram illustrates the five layers that exist on the palms and soles of the feet.<\/em><\/figcaption><\/figure>\n<h3>Stratum Basale<\/h3>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3542\">stratum basale<\/a><\/strong>\u00a0is the innermost (or deepest) layer of the epidermis. It is separated from the dermis by a membrane called the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3815\">basement membrane<\/a><\/strong>. The stratum basale contains stem cells \u2014 called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3811\">basal cells<\/a><\/strong>\u00a0\u2014 which divide to form all the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3524\">keratinocytes<\/a> of the epidermis. When keratinocytes first form, they are cube-shaped and contain almost no keratin. As more keratinocytes are produced, previously formed cells are pushed up through the stratum basale. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3545\">Melanocytes<\/a>\u00a0and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3527\">Merkel cells<\/a>\u00a0are also found in the stratum basale. The Merkel cells are especially numerous in touch-sensitive areas, such as the fingertips and lips.<\/p>\n<h3>Stratum Spinosum<\/h3>\n<p>Just above the stratum basale is the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3546\">stratum spinosum<\/a><\/strong>. This is the\u00a0thickest\u00a0of the four epidermal layers. The keratinocytes in this layer have begun to accumulate keratin, and they have become tougher and flatter. Spiny cellular projections form between the keratinocytes and hold them together. In addition to keratinocytes, the stratum spinosum contains the immunologically active <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3540\">Langerhans cells<\/a>.<\/p>\n<h3>Stratum Granulosum<\/h3>\n<p>The next layer above the stratum spinosum is the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3547\">stratum granulosum<\/a><\/strong>. In this layer, keratinocytes have become nearly filled with <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3525\">keratin<\/a>, giving their cytoplasm a granular appearance.\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3559\">Lipids<\/a>\u00a0are released by keratinocytes in this layer to form a\u00a0lipid\u00a0barrier in the epidermis. Cells in this layer have also started to die, because they are becoming too far removed from\u00a0blood vessels\u00a0in the dermis to receive\u00a0nutrients. Each dying cell digests its own\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3705\">nucleus<\/a>\u00a0and\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3465\">organelles<\/a>, leaving behind only a tough, keratin-filled shell.<\/p>\n<h3>Stratum Lucidum<\/h3>\n<p>Only on the palms of the hands and soles of the feet, the next layer above the stratum granulosum is the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3548\">stratum lucidum<\/a><\/strong>. This is a layer consisting of stacks of translucent, dead keratinocytes that provide extra protection to the underlying layers.<\/p>\n<h3>Stratum Corneum<\/h3>\n<p>The uppermost layer of the epidermis everywhere on the body is the\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3549\">stratum corneum<\/a><\/strong>. This layer is made of flat, hard, tightly packed dead keratinocytes that form a waterproof keratin barrier to protect the underlying layers of the epidermis. Dead cells from this layer are constantly shed from the surface of the body. The shed cells are continually replaced by cells moving up from lower layers of the epidermis. It takes a period of about 48 days for newly formed keratinocytes in the stratum basale to make their way to the top of the stratum corneum to replace shed cells.<\/p>\n<div>\n<h1>Functions of the Epidermis<\/h1>\n<\/div>\n<p>The epidermis has several crucial functions in the body. These functions include protection,\u00a0water\u00a0retention, and vitamin D synthesis.<\/p>\n<h2>Protective Functions<\/h2>\n<p>The epidermis provides protection to underlying tissues from physical damage, pathogens, and UV light.<\/p>\n<h3>Protection from Physical Damage<\/h3>\n<p>Most of the physical protection of the epidermis is provided by its tough outer layer, the stratum corneum. Because of this layer, minor scrapes and scratches generally do not cause significant damage to the skin or underlying tissues. Sharp objects and rough surfaces have difficulty penetrating or removing the tough, dead, keratin-filled cells of the stratum corneum. If cells in this layer are pierced or scraped off, they are quickly replaced by new cells moving up to the surface from lower skin layers.<\/p>\n<h3>Protection from Pathogens<\/h3>\n<figure id=\"attachment_3550\" aria-describedby=\"caption-attachment-3550\" style=\"width: 337px\" class=\"wp-caption alignright\"><img class=\" wp-image-3550\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Scraped-knee-by-Alpha-on-flickr-1.jpg\" alt=\"Skin: Protection from Pathogens\" width=\"337\" height=\"253\"><figcaption id=\"caption-attachment-3550\" class=\"wp-caption-text\"><em>Figure 10.3.3 This scrape on the knee provides an opportunity for bacteria to enter the body through the broken skin.<\/em><\/figcaption><\/figure>\n<p>When pathogens such as viruses and bacteria try to enter the body, it is virtually impossible for them to enter through intact epidermal layers. Generally, pathogens can enter the skin only if the epidermis has been breached, for example by a cut, puncture, or scrape (like the one pictured in Figure 10.3.3). That\u2019s why it is important to clean and cover even a <em>minor<\/em> wound in the epidermis. This helps ensure that pathogens do not use the wound to enter the body. Protection from pathogens is also provided by conditions at or near the skin surface. These include relatively high acidity (pH\u00a0of about 5.0), low amounts of\u00a0water, the presence of antimicrobial substances produced by epidermal cells, and\u00a0competition\u00a0with non-pathogenic microorganisms that normally live on the epidermis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Protection from UV Light<\/h3>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3537\">UV light<\/a>\u00a0that penetrates the epidermis can damage epidermal cells. In particular, it can cause\u00a0mutations\u00a0in\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_277\">DNA<\/a>\u00a0that lead to the\u00a0development\u00a0of\u00a0skin <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3513\">cancer<\/a>, in which epidermal cells grow out of control. UV light can also destroy vitamin B9 (in forms such as folate or folic acid), which is needed for good health and successful\u00a0reproduction. In a person with light skin, just an hour of exposure to intense sunlight can reduce the body\u2019s vitamin B9 level by <em>50 per cent.<\/em><\/p>\n<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3526\">Melanocyte<\/a>s in the stratum basale of the epidermis contain small\u00a0organelles\u00a0called\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3759\">melanosomes<\/a><\/strong>, which produce, store, and transport the dark brown pigment <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3753\">melanin<\/a>. As melanosomes become full of melanin, they move into thin extensions of the melanocytes. From there, the melanosomes are transferred to <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3524\">keratinocytes<\/a>\u00a0in the epidermis, where they absorb UV light that strikes the skin. This prevents the light from penetrating deeper into the skin, where it can cause damage. The more melanin there is in the skin, the more UV light can be absorbed.<\/p>\n<h2>Water\u00a0Retention<\/h2>\n<p>Skin's ability\u00a0to hold water and not lose it to the surrounding environment is due mainly to the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3549\">stratum corneum<\/a>.\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3559\">Lipids<\/a>\u00a0arranged in an organized way among the cells of the stratum corneum form a barrier to water loss from the epidermis. This is critical for maintaining healthy skin and preserving proper water balance in the body.<\/p>\n<p>Although the skin is impermeable to water, it is not impermeable to\u00a0<em>all <\/em>substances. Instead, the skin is\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3767\"><em>selectively<\/em>\u00a0permeable<\/a>, allowing certain fat-soluble substances to pass through the epidermis. The selective permeability of the epidermis is both a benefit and a risk.<\/p>\n<ul>\n<li>Selective permeability allows certain medications to enter the bloodstream through the capillaries in the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3875\">dermis<\/a>. This is the basis of medications that are delivered using topical ointments, or patches (see Figure 10.3.4) that are applied to the skin. These include steroid hormones, such as <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3903\">estrogen<\/a> (for hormone replacement therapy), scopolamine (for motion sickness), nitroglycerin (for heart problems), and nicotine (for people trying to quit smoking).<\/li>\n<li>Selective permeability of the epidermis also allows certain harmful substances to enter the body through the skin. Examples include the heavy metal lead, as well as many pesticides.<\/li>\n<\/ul>\n<figure id=\"attachment_3554\" aria-describedby=\"caption-attachment-3554\" style=\"width: 394px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-3554\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Nicoderm-1.jpg\" alt=\"Skin - selectively permeable\" width=\"394\" height=\"262\"><figcaption id=\"caption-attachment-3554\" class=\"wp-caption-text\"><em>Figure 10.3.4 This skin patch delivers small amounts of nicotine through the skin of a person in a smoking cessation program.<\/em><\/figcaption><\/figure>\n<h3>Vitamin D Synthesis<\/h3>\n<p>Vitamin D is a nutrient that is needed in the human body for the absorption of calcium from food. Molecules of a lipid compound named 7-dehydrocholesterol are precursors of vitamin D. These molecules are present in the stratum basale and stratum spinosum layers of the epidermis. When UV light strikes the molecules, it changes them to vitamin D3. In the kidneys, vitamin D3 is converted to calcitriol, which is the form of vitamin D that is active in the body.<\/p>\n<div>\n<h1>What Gives Skin Its Colour?<\/h1>\n<\/div>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3753\">Melanin<\/a><\/strong> in the epidermis is the main substance that determines the colour of human skin. It explains most of the variation in skin colour in people around the world. Two other substances also contribute to skin colour, however, especially in light-skinned people: carotene and hemoglobin.<\/p>\n<ul>\n<li>The pigment\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3749\">carotene<\/a><\/strong>\u00a0is present in the epidermis and gives skin a yellowish tint, especially in skin with low levels of melanin.<\/li>\n<li><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3556\">Hemoglobin<\/a><\/strong> is a red pigment found in red\u00a0blood\u00a0cells. It is visible through skin as a pinkish tint, mainly in skin with low levels of melanin. The pink colour is most visible when capillaries in the underlying dermis dilate, allowing greater blood flow near the surface.<\/li>\n<\/ul>\n<p>Hear what Bill Nye has to say about the subject of skin colour in the video <a href=\"https:\/\/youtu.be\/zOkj5jgC4sM\">here<\/a>.<\/p>\n<div>\n<h1>Bacteria\u00a0on Skin<\/h1>\n<\/div>\n<figure id=\"attachment_3557\" aria-describedby=\"caption-attachment-3557\" style=\"width: 251px\" class=\"wp-caption alignleft\"><img class=\" wp-image-3557\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Staphylococcus-aureus-bacteria-by-Microbe-World-on-flickr-1.jpg\" alt=\"Skin - protects against bacteria\" width=\"251\" height=\"170\"><figcaption id=\"caption-attachment-3557\" class=\"wp-caption-text\"><em>Figure 10.3.5 The bacterium Staphylococcus epidermidis is a common microorganism living on healthy human skin.<\/em><\/figcaption><\/figure>\n<p>The surface of the human skin normally provides a home to countless numbers of bacteria. Just one square inch of skin normally has an average of about 50 million bacteria. These generally harmless bacteria represent roughly one thousand bacterial species (including the one in Figure 10.3.5) from 19 different bacterial phyla. Typical variations in the moistness and oiliness of the skin produce a variety of rich and diverse habitats for these microorganisms. For example, the skin in the armpits is warm and moist and often hairy, whereas the skin on the forearms is smooth and dry. These two areas of the human body are as diverse to microorganisms as rainforests and deserts are to larger organisms. The density of bacterial populations on the skin depends largely on the region of the skin and its ecological characteristics. For example, oily surfaces, such as the face, may contain over 500 million bacteria per square inch. Despite the huge number of individual microorganisms living on the skin, their total volume is only about the size of a pea.<\/p>\n<p>In general, the normal microorganisms living on the skin keep one another in check, and thereby play an important role in keeping the skin healthy.\u00a0If the balance of microorganisms is disturbed, however, there may be an overgrowth of certain\u00a0species, and this may result in an infection. For example, when a patient is prescribed antibiotics, it may kill off normal bacteria and allow an overgrowth of single-celled yeast. Even if skin is disinfected, no amount of cleaning can remove all of the microorganisms it contains. Disinfected areas are also quickly recolonized by bacteria residing in deeper areas (such as\u00a0hair\u00a0follicles) and in adjacent areas of the skin.<\/p>\n<div>\n<h1>Feature: Myth vs. Reality<\/h1>\n<\/div>\n<p>Because of the negative health effects of excessive UV light exposure, it is important to know the facts about protecting the skin from UV light.<\/p>\n<table class=\"grid\" style=\"border-collapse: collapse;width: 84.1914%;height: 84px\" border=\"0\">\n<tbody>\n<tr style=\"height: 14px\">\n<td style=\"width: 29.1878%;height: 14px\">\n<h2><span style=\"color: #ff0000\">Myth<\/span><\/h2>\n<\/td>\n<td style=\"width: 55.0036%;height: 14px\">\n<h2><span style=\"color: #339966\">Reality<\/span><\/h2>\n<\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"width: 29.1878%;height: 14px\"><em>\"Sunblock and sunscreen are just different names for the same type of product. They both work the same way and are equally effective.\"<\/em><\/td>\n<td style=\"width: 55.0036%;height: 14px\"><strong><span style=\"font-size: 16px\">Sunscreens and sunblocks are different types of products that protect the skin from UV light in different ways. They are not equally effective. Sunblocks are opaque, so they do not let light pass through. They prevent most of the rays of UV light from penetrating to the skin surface. Sunblocks are generally stronger and more effective than sunscreens. Sunblocks also do not need to be reapplied as often as sunscreens. Sunscreens, in contrast, are transparent once they are applied the skin. Although they can prevent most UV light from penetrating the skin when first applied, the active ingredients in sunscreens tend to break down when exposed to UV light. Sunscreens, therefore, must be reapplied often to remain effective.<\/span><\/strong><\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"width: 29.1878%;height: 14px\"><em><span style=\"font-size: 16px\">\"The skin needs to be protected from UV light only on sunny days. When the sky is cloudy, UV light cannot penetrate to the ground and harm the skin.\"<\/span><\/em><\/td>\n<td style=\"width: 55.0036%;height: 14px\"><strong><span style=\"font-size: 16px\">Even on cloudy days, a significant amount of UV radiation penetrates the atmosphere to strike Earth\u2019s surface. Therefore, using sunscreens or sunblocks to protect exposed skin is important even when there are\u00a0clouds\u00a0in the sky.<\/span><\/strong><\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"width: 29.1878%;height: 14px\"><em><span style=\"font-size: 16px\">\"People who have dark skin, such as African Americans, do not need to worry about skin damage from UV light.\"<\/span><\/em><\/td>\n<td style=\"width: 55.0036%;height: 14px\"><strong><span style=\"font-size: 16px\">No matter what colour skin you have, your skin can be damaged by too much exposure to UV light. Therefore, even dark-skinned people should use sunscreens or sunblocks to protect exposed skin from UV light.<\/span><\/strong><\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"width: 29.1878%;height: 14px\"><em><span style=\"font-size: 16px\">\"Sunscreens with an SPF (sun protection factor) of 15 are adequate to fully protect the skin from UV light.\"<\/span><\/em><\/td>\n<td style=\"width: 55.0036%;height: 14px\"><strong><span style=\"font-size: 16px\">Most dermatologists recommend using sunscreens with an SPF of at least 35 for adequate protection from UV light. They also recommend applying sunscreens at least 20 minutes before\u00a0sun\u00a0exposure and reapplying sunscreens often, especially if you are sweating or spending time in the water.<\/span><\/strong><\/td>\n<\/tr>\n<tr style=\"height: 14px\">\n<td style=\"width: 29.1878%;height: 14px\"><em><span style=\"font-size: 16px\">\"Using tanning beds is safer than tanning outside in natural sunlight.\"<\/span><\/em><\/td>\n<td style=\"width: 55.0036%;height: 14px\"><strong><span style=\"font-size: 16px\">The light in tanning beds is UV light, and it can do the same damage to the skin as the natural UV light in sunlight. This is evidenced by the fact that people who regularly use tanning beds have significantly higher rates of\u00a0skin cancer\u00a0than people who do not. It is also the reason that the use of tanning beds is prohibited in many places in people who are under the age of 18, just as youth are prohibited from using harmful substances, such as tobacco and alcohol.<\/span><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">10.3 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3899\">epidermis<\/a> is the outer of the two main layers of the skin. It is very thin, but has a complex structure.<\/li>\n<li>Cell types in the epidermis include <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3524\">keratinocytes<\/a> that produce <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3525\">keratin<\/a> and make up 90 per cent of epidermal cells, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3526\">melanocytes<\/a> that produce <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3753\">melanin<\/a>, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3540\">Langerhans cells<\/a> that fight <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3707\">pathogens<\/a> in the skin, and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3527\">Merkel cells<\/a> that respond to light touch.<\/li>\n<li>The epidermis in most parts of the body consists of four distinct layers. A fifth layer occurs only in the epidermis of the palms of the hands and soles of the feet.<\/li>\n<li>The innermost layer of the epidermis is the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3542\">stratum basale<\/a>, which contains stem cells that divide to form new keratinocytes. The next layer is the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3546\">stratum spinosum<\/a>, which is the\u00a0thickest layer and contains Langerhans cells and spiny keratinocytes. This is followed by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3547\">stratum granulosum<\/a>, in which keratinocytes are filling with keratin and starting to die. The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3548\">stratum lucidum<\/a> is next, but only on the palms and soles. It consists of translucent dead keratinocytes. The outermost layer is the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3549\">stratum corneum<\/a>, which consists of flat, dead, tightly packed keratinocytes that form a tough, waterproof barrier for the rest of the epidermis.<\/li>\n<li>Functions of the epidermis include protecting underlying tissues from physical damage and pathogens. Melanin in the epidermis absorbs and protects underlying tissues from <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_3537\">UV light<\/a>. The epidermis also prevents loss of water from the body and synthesizes vitamin D.<\/li>\n<li>Melanin is the main pigment that determines the colour of human skin. The pigments carotene and hemoglobin, however, also contribute to skin colour, especially in skin with low levels of melanin.<\/li>\n<li>The surface of healthy skin normally is covered by vast numbers of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4478_2588\">bacteria<\/a> representing about one thousand\u00a0species\u00a0from 19 phyla. Different areas of the body provide diverse habitats for skin microorganisms. Usually, microorganisms on the skin keep each other in check unless their balance is disturbed.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">10.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What is the epidermis?<\/li>\n<li>Identify the types of cells in the epidermis.<\/li>\n<li>Describe the layers of the epidermis.<\/li>\n<li>\n<div id=\"h5p-360\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-360\" class=\"h5p-iframe\" data-content-id=\"360\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"10.3 Label the layers of the Epidermis\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>State one function of each of the four epidermal layers found all over the body.<\/li>\n<li>Explain three ways the epidermis protects the body.<\/li>\n<li>What makes the skin waterproof?<\/li>\n<li>Why is the selective permeability of the epidermis both a benefit and a risk?<\/li>\n<li>How is vitamin D synthesized in the epidermis?<\/li>\n<li>Identify three pigments that impart colour to skin.<\/li>\n<li>Describe bacteria that normally reside on the skin, and explain why they do not usually cause infections.<\/li>\n<li>Explain why the keratinocytes at the surface of the epidermis are dead, while keratinocytes located deeper in the epidermis are still alive.<\/li>\n<li>Which layer of the epidermis contains keratinocytes that have begun to die?<\/li>\n<li>\n<div id=\"h5p-361\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-361\" class=\"h5p-iframe\" data-content-id=\"361\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"10.3 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Explain why our skin is not permanently damaged if we rub off some of the surface layer by using a rough washcloth.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\" style=\"text-align: left\"><span style=\"color: #ffffff\">10.3 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/www.youtube.com\/watch?v=27lMmdmy-b8<\/p>\n<p style=\"text-align: center\">Jonathan Eisen: Meet your microbes, TED,\u00a02015.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=9AcQXnOscQ8<\/p>\n<p style=\"text-align: center\">Why Do We Blush?, SciShow, 2014.<\/p>\n<p>https:\/\/www.youtube.com\/watch?v=_r4c2NT4naQ<\/p>\n<p style=\"text-align: center\">The science of skin colour - Angela Koine Flynn, TED-Ed, 2016.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 10.3.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Sunburn.jpg\" rel=\"cc:attributionURL\">Sunburn<\/a> by <a class=\"extiw\" title=\"wikipedia:User:QuinnHK\" href=\"https:\/\/en.wikipedia.org\/wiki\/User:QuinnHK\">QuinnHK<\/a>\u00a0at\u00a0<a class=\"extiw\" title=\"wikipedia:\" href=\"https:\/\/en.wikipedia.org\/wiki\/\">English Wikipedia<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:en:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/en:public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 10.3.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0353_Epidermis.png\" rel=\"cc:attributionURL\">Blausen_0353_Epidermis<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license.<\/p>\n<p><strong>Figure 10.3.3<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/avlxyz\/10975825785\" rel=\"cc:attributionURL\">Isaac's scraped knee close-up<\/a> by <a class=\"owner-name truncate\" title=\"Go to Alpha's photostream\" href=\"https:\/\/www.flickr.com\/photos\/avlxyz\/\" data-track=\"attributionNameClick\">Alpha<\/a> on <a href=\"http:\/\/flickr.com\" rel=\"cc:attributionURL\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<p><strong>Figure 10.3.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Nicoderm.JPG\" rel=\"cc:attributionURL\">Nicoderm<\/a> by <a title=\"User:RegBarc\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:RegBarc\">RegBarc<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY-SA 3.0<\/a> (http:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/) license. (No machine-readable author provided for original.)<\/p>\n<p><strong>Figure 10.3.5<\/strong><\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/microbeworld\/5619255092\">Staphylococcus aureus bacteria, MRSA<\/a> by <a class=\"owner-name truncate\" title=\"Go to Microbe World's photostream\" href=\"https:\/\/www.flickr.com\/photos\/microbeworld\/\" data-track=\"attributionNameClick\">Microbe World<\/a> on <a href=\"http:\/\/flickr.com\">Flickr<\/a> is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/\" rel=\"license\">CC BY-NC-SA 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/2.0\/) license.<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Blausen.com staff. (2014). Medical gallery of Blausen Medical 2014. <em>WikiJournal of Medicine 1<\/em> (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436.<\/p>\n<p class=\"hanging-indent\">Jeff Bone 'n' Pookie. (2020, July 19). Bill Nye the science guy explains we have different skin color. Youtube. https:\/\/www.youtube.com\/watch?v=zOkj5jgC4sM&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">SciShow. (2014, July 15). Why do we blush? YouTube. https:\/\/www.youtube.com\/watch?v=9AcQXnOscQ8<\/p>\n<p class=\"hanging-indent\">TED. (2015, July 17). Jonathan Eisen: Meet your microbes. YouTube. https:\/\/www.youtube.com\/watch?v=27lMmdmy-b8<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2016, February 16). The science of skin color - Angela Koine Flynn. 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