{"id":4419,"date":"2019-06-24T12:38:36","date_gmt":"2019-06-24T12:38:36","guid":{"rendered":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/4-3-variation-in-cells-3\/"},"modified":"2023-11-30T17:53:16","modified_gmt":"2023-11-30T17:53:16","slug":"4-3-variation-in-cells-3","status":"publish","type":"chapter","link":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/chapter\/4-3-variation-in-cells-3\/","title":{"raw":"4.3\u00a0Variation in Cells","rendered":"4.3\u00a0Variation in Cells"},"content":{"raw":"&nbsp;\r\n<div>\r\n\r\n[caption id=\"attachment_1568\" align=\"aligncenter\" width=\"400\"]<img class=\"wp-image-1568\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Borrelia_hermsii_Bacteria_13758011613-2.jpg\" alt=\"Image shows a large red blood cell, with a filamentous green bacterium resting on its surface.\" width=\"400\" height=\"300\" \/> <em>Figure 4.3.1 A bacterium attacks a human erythrocyte. Both are cells.<\/em>[\/caption]\r\n<h1>Bacteria\u00a0Attack!<\/h1>\r\n<\/div>\r\nThe colourful image in Figure 4.3.1 shows a bacterial cell (in green) attacking human red blood cells. The bacterium causes a disease called relapsing fever. The bacterial and human cells look very different in size and shape. Although all living cells have certain things in common \u2014 such as a plasma membrane and cytoplasm \u2014 different types of cells, even within the same organism, may have their own unique structures and functions. Cells with different functions generally have different shapes that suit them for their particular job. Cells vary not only in shape, but also in size, as this example shows. In most organisms, however, even the largest cells are no bigger than the period at the end of this sentence. Why are cells so small?\r\n<div>\r\n<h1>Explaining Cell Size<\/h1>\r\n<\/div>\r\nMost organisms, even very large ones, have microscopic cells. Why don't cells get bigger instead of remaining tiny and multiplying? Why aren't you one giant cell rolling around school? What limits cell size?\r\n\r\nOnce you know how a cell functions, the answers to these questions are clear. To carry out life processes, a cell must be able to quickly pass substances in and out of the cell. For example, it must be able to pass\u00a0nutrients\u00a0and oxygen into the cell and waste products out of the cell. Anything that enters or leaves a cell must cross its outer surface. The size of a cell is limited by its need to pass substances across that outer surface.\r\n\r\nLook at the three cubes in Figure 4.3.2. A<span style=\"text-align: initial; font-size: 1em;\"> larger cube has less surface area relative to its volume than a smaller cube. This relationship also applies to cells \u2014 a larger cell has less surface area relative to its volume than a smaller cell. A cell with a larger volume also needs more nutrients and oxygen, and produces more waste. Because all of these substances must pass through the surface of the cell, a cell with a large volume will not have enough surface area to allow it to meet its needs. The <\/span><em style=\"text-align: initial; font-size: 1em;\">larger<\/em><span style=\"text-align: initial; font-size: 1em;\"> the cell is, the <\/span><em style=\"text-align: initial; font-size: 1em;\">smaller<\/em><span style=\"text-align: initial; font-size: 1em;\"> its ratio of surface area to volume, and the more difficult it will be for the cell to get rid of its waste and take in necessary substances. This is what limits the size of the cell.<\/span>\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n[caption id=\"attachment_1570\" align=\"aligncenter\" width=\"741\"]<img class=\"wp-image-1570\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cell-Size-2.png\" alt=\"Image shows three cubes: a small, a medium and a large. The cube with length of 1 has a surface area to volume ratio of 6:1. The cube with a length of 2 has a surface area to volume ratio of 3:1 and the cube with the length of 3 has a surface area to volume ratio of 2:1.\" width=\"741\" height=\"556\" \/> <em>Figure 4.3.2 Surface area to volume ratio.<\/em>[\/caption]\r\n\r\n<div>\r\n<h1>Cell Form and Function<\/h1>\r\n<\/div>\r\nCells with different functions often have varying shapes. The cells pictured below (Figure 4.3.3) are just a few examples of the many different shapes that human cells may have. Each type of cell\u00a0 has characteristics that help it do its job. The job of the nerve cell, for example, is to carry messages to other cells. The nerve cell has many long extensions that reach out in all directions, allowing it to pass messages to many other cells at once. Do you see the tail of each tiny sperm cell? Its tail helps a sperm cell \"swim\" through fluids in the female reproductive tract in order to reach an egg cell. The white blood cell has the job of destroying bacteria and other pathogens. It is a large cell that can engulf foreign invaders.\r\n<div>\r\n\r\n[h5p id=\"469\"]\r\n\r\n<em>Figure 4.3.3 Human cells may have many different shapes that help them to do their jobs.<\/em>\r\n\r\n<\/div>\r\n<div>\r\n<h1>Cells With and Without a\u00a0Nucleus<\/h1>\r\n<\/div>\r\nThe\u00a0[pb_glossary id=\"5797\"]nucleus[\/pb_glossary]\u00a0is a basic\u00a0cell structure\u00a0present in many \u2014 but not\u00a0<em>all \u2014<\/em>\u00a0living cells. The\u00a0[pb_glossary id=\"5797\"]nucleus[\/pb_glossary]\u00a0of a cell is a structure in the cytoplasm that is surrounded by a membrane (the nuclear membrane) and contains\u00a0[pb_glossary id=\"277\"]DNA[\/pb_glossary]. Based on whether or not they have a nucleus, there are two basic types of cells: [pb_glossary id=\"1572\"]prokaryotic[\/pb_glossary] cells and [pb_glossary id=\"1573\"]eukaryotic[\/pb_glossary] cells.\r\n<h2>Prokaryotic Cells<\/h2>\r\n[caption id=\"attachment_1574\" align=\"alignright\" width=\"392\"]<img class=\"wp-image-1574\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2000px-Average_prokaryote_cell-_en.svg_-2.png\" alt=\"Image shows a diagram of a bacterium. The bacterium is smaller than a typical eukaryotic cell, has fewer organelles and contains no membrane-bound organelles.\" width=\"392\" height=\"319\" \/> <em>Figure 4.3.3 Bacteria are prokaryotes, meaning they do not have a nucleus. Their DNA is contained in a region called the nucleoid.<\/em>[\/caption]\r\n\r\n<strong>[pb_glossary id=\"1572\"]Prokaryotic[\/pb_glossary] cells<\/strong> are cells without a nucleus. The [pb_glossary id=\"277\"]DNA[\/pb_glossary] in prokaryotic cells is in the cytoplasm, rather than enclosed within a nuclear membrane.\u00a0 In addition, these cells are typically smaller than eukaryotic cells and contain fewer organelles.\u00a0 Prokaryotic cells are found in single-celled organisms, such as the bacterium represented by the model in Figure 4.3.3. Organisms with prokaryotic cells are called <strong>prokaryotes<\/strong>. They were the first type of organisms to evolve, and they are still the most common organisms today.\r\n<div>\r\n\r\n&nbsp;\r\n\r\n<\/div>\r\n<h2>Eukaryotic Cells<\/h2>\r\n[caption id=\"attachment_1577\" align=\"alignnone\" width=\"2500\"]<img class=\"size-full wp-image-1577\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Animal-Cell-1-2.png\" alt=\"Image shows a diagram of a eukaryotic cell. The cell has many organelles labelled, including: nucleus, nucleolus, rough endoplasmic reticulum, smooth endoplasmic reticulum, Golgi body, vesicles, mitochondria and centrioles.\" width=\"2500\" height=\"1000\" \/> <em>Figure 4.3.4 Eukaryotic cells, like this animal cell, contain a nucleus and many other membrane-bound organelles.<\/em>[\/caption]\r\n\r\n<strong>[pb_glossary id=\"1573\"]Eukaryotic[\/pb_glossary] cells<\/strong> are cells that contain a [pb_glossary id=\"5797\"]nucleus[\/pb_glossary]. A typical eukaryotic cell is represented by the model in Figure 4.3.4. Eukaryotic cells are usually larger than prokaryotic cells. They are found in some single-celled and all multicellular organisms. Organisms with eukaryotic cells are called <strong>eukaryotes<\/strong>, and they range from\u00a0fungi\u00a0to\u00a0humans.\r\n\r\nBesides a nucleus, eukaryotic cells also contain other\u00a0organelles. An\u00a0<strong>[pb_glossary id=\"5557\"]organelle[\/pb_glossary]<\/strong>\u00a0is a structure within the cytoplasm that performs a specific job in the cell.\u00a0Organelles\u00a0called\u00a0[pb_glossary id=\"5783\"]mitochondria[\/pb_glossary], for example, provide\u00a0[pb_glossary id=\"5753\"]energy[\/pb_glossary]\u00a0to the cell, and organelles called vesicles store substances in the cell. Organelles allow [pb_glossary id=\"1573\"]eukaryotic[\/pb_glossary] cells to carry out more functions than [pb_glossary id=\"1572\"]prokaryotic[\/pb_glossary] cells can.\r\n\r\nInterestingly, scientists think that mitochondria were once free-living prokaryotes that infected (or were engulfed by) larger cells. The two organisms developed a symbiotic relationship that was beneficial to both of them, resulting in the smaller prokaryote becoming an organelle within the larger cell. This is called endosymbiotic theory, and it is supported by a lot of evidence, including the fact that [pb_glossary id=\"5783\"]mitochondria[\/pb_glossary] have their own [pb_glossary id=\"277\"]DNA[\/pb_glossary] separate from the DNA in the nucleus of the eukaryotic cell. Endosymbiotic theory will be described in more detail in later sections, and it's also discussed in the video below.\r\n<div>\r\n\r\nhttps:\/\/www.youtube.com\/watch?v=FGnS-Xk0ZqU\r\n<p class=\"title style-scope ytd-video-primary-info-renderer\" style=\"text-align: center;\">Endosymbiotic Theory, Amoeba Sisters, 2017.<\/p>\r\n\r\n<div class=\"textbox textbox--key-takeaways\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\">4.3 Summary<\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ul>\r\n \t<li>Cells must be very small so they have a large enough surface area-to-volume ratio to maintain normal cell processes.<\/li>\r\n \t<li>Cells with different functions often have different shapes.<\/li>\r\n \t<li>[pb_glossary id=\"1572\"]Prokaryotic[\/pb_glossary] cells do not have a nucleus. [pb_glossary id=\"1573\"]Eukaryotic [\/pb_glossary]cells\u00a0<em>do<\/em>\u00a0have a [pb_glossary id=\"5797\"]nucleus[\/pb_glossary], along with other\u00a0[pb_glossary id=\"5557\"]organelles[\/pb_glossary].<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div>\r\n<div class=\"textbox textbox--exercises\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.3 Review Questions<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<ol>\r\n \t<li>Explain why most cells are very small.<\/li>\r\n \t<li>Discuss variations in the form and function of cells.<\/li>\r\n \t<li>[h5p id=\"470\"]<\/li>\r\n \t<li>[h5p id=\"471\"]<\/li>\r\n \t<li>Do human cells have organelles? Explain your answer.<\/li>\r\n \t<li>Which are usually larger \u2013 prokaryotic or eukaryotic cells? What do you think this means for their relative ability to take in needed substances and release wastes? Discuss your answer.<\/li>\r\n \t<li>DNA in eukaryotes is enclosed within the _______ \u00a0________.<\/li>\r\n \t<li>Name three different types of cells in humans.<\/li>\r\n \t<li>Which organelle provides energy in eukaryotic cells?<\/li>\r\n \t<li>What is a function of a vesicle in a cell?<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.3 Explore More<\/span><\/h1>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n\r\nhttps:\/\/www.youtube.com\/watch?time_continue=1&amp;v=9i7kAt97XYU&amp;feature=emb_logo\r\n<p style=\"text-align: center;\">How we think complex cells evolved - Adam Jacobson, TED-Ed, 2015.<\/p>\r\nhttps:\/\/www.youtube.com\/watch?v=Pxujitlv8wc\r\n<p style=\"text-align: center;\">Prokaryotic vs. Eukaryotic Cells (updated), Amoeba Sisters, 2018.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n<h2>Attributions<\/h2>\r\n<strong>Figure 4.3.1<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Borrelia_hermsii_Bacteria_(13758011613).jpg\" rel=\"cc:attributionURL\">Borrelia_hermsii_Bacteria_(13758011613)<\/a> by <a href=\"https:\/\/www.flickr.com\/people\/54591706@N02\">NAID<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 4.3.2<\/strong>\r\n\r\nCell Size by Christine Miller is released into the <a href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">Public Domain<\/a> (https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/).\r\n\r\n<strong>Figure 4.3.3<\/strong>\r\n<ul>\r\n \t<li><a style=\"font-size: 1em;\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:BioTek-Wikipedia-Image.tif\">Chondrocyte. BioTek-Wikipedia-Image<\/a><span style=\"font-size: 1em;\"> by BioTek Instruments, Inc. on Wikimedia Commons is used under a <\/span><a style=\"font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY-SA 3.0<\/a><span style=\"font-size: 1em;\"> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en) license. <\/span><\/li>\r\n \t<li><a style=\"font-size: 1em;\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Neutrophil_with_anthrax_copy.jpg\">Neutrophil with anthrax copy<\/a><span style=\"font-size: 1em;\"> by Volker Brinkmann from <\/span><a style=\"font-size: 1em;\" href=\"https:\/\/journals.plos.org\/plospathogens\/issue?id=10.1371\/issue.ppat.v01.i03\">PLOS Pathogens<\/a><span style=\"font-size: 1em;\"> on Wikimedia Commons is used under a\u00a0<\/span><a style=\"font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en\">CC BY 2.5<\/a><span style=\"font-size: 1em;\"> (https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en) license.\u00a0<\/span><\/li>\r\n \t<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:PLoSBiol4.e126.Fig6fNeuron.jpg\"><em>PLoSBio<\/em>l4.e126.Fig6fNeuron<\/a> by Lee, et al. from <a href=\"https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.0040029\">PLOS Biology<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en\">CC BY 2.5<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en) license.<\/li>\r\n \t<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Sperm_(265_33)_human.jpg\">Sperm (265 33) human<\/a> by <a class=\"extiw\" title=\"cs:Josef Reischig\" href=\"https:\/\/cs.wikipedia.org\/wiki\/Josef_Reischig\">Doc. RNDr. Josef Reischig, CSc.<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<strong style=\"text-align: initial; font-size: 1em;\">\r\nFigure 4.3.4<\/strong>\r\n\r\n<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Average_prokaryote_cell-_en.svg\" rel=\"cc:attributionURL\">Model of a prokaryotic cell: bacterium<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).\r\n\r\n<strong>Figure 4.3.5<\/strong>\r\n\r\nAnimal Cell adapted by Christine Miller is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"license\">CC0 1.0<\/a> (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) public domain dedication license. (Original image, <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Animal_Cell_Unannotated.svg\">Animal Cell Unannotated,<\/a> is by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kelvin13\">Kelvin Song<\/a> on Wikimedia Commons.)\r\n<h2>References<\/h2>\r\n<p class=\"hanging-indent\">Amoeba Sisters. (2017, May 3). Endosymbiotic theory. YouTube. https:\/\/www.youtube.com\/watch?v=FGnS-Xk0ZqU&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">Amoeba Sisters. (2018, July 30). Prokaryotic vs. eukaryotic cells (updated). YouTube. https:\/\/www.youtube.com\/watch?v=Pxujitlv8wc&amp;feature=youtu.be<\/p>\r\n<p class=\"hanging-indent\">Brinkmann, V. (November 2005). Neutrophil engulfing Bacillus anthracis. <em>PLoS Pathogens 1<\/em> (3): Cover page [digital image]. DOI:10.1371. https:\/\/journals.plos.org\/plospathogens\/issue?id=10.1371\/issue.ppat.v01.i03<\/p>\r\n<p class=\"hanging-indent\">Lee, W.C.A., Huang, H., Feng, G., Sanes, J.R., Brown, E.N., et al. (2005, December 27) Figure 6f, slightly altered (plus scalebar, minus letter \"f\".) [digital image]. Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex. <em>PLoS Biology, 4<\/em>(2), e29. doi:10.1371\/journal.pbio.0040029. https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.0040029<\/p>\r\n<p class=\"hanging-indent\">TED-Ed. (2015, February 17). How we think complex cells evolved - Adam Jacobson. https:\/\/www.youtube.com\/watch?v=9i7kAt97XYU&amp;feature=youtu.be<\/p>\r\n&nbsp;\r\n\r\n&nbsp;","rendered":"<p>&nbsp;<\/p>\n<div>\n<figure id=\"attachment_1568\" aria-describedby=\"caption-attachment-1568\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1568\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Borrelia_hermsii_Bacteria_13758011613-2.jpg\" alt=\"Image shows a large red blood cell, with a filamentous green bacterium resting on its surface.\" width=\"400\" height=\"300\" \/><figcaption id=\"caption-attachment-1568\" class=\"wp-caption-text\"><em>Figure 4.3.1 A bacterium attacks a human erythrocyte. Both are cells.<\/em><\/figcaption><\/figure>\n<h1>Bacteria\u00a0Attack!<\/h1>\n<\/div>\n<p>The colourful image in Figure 4.3.1 shows a bacterial cell (in green) attacking human red blood cells. The bacterium causes a disease called relapsing fever. The bacterial and human cells look very different in size and shape. Although all living cells have certain things in common \u2014 such as a plasma membrane and cytoplasm \u2014 different types of cells, even within the same organism, may have their own unique structures and functions. Cells with different functions generally have different shapes that suit them for their particular job. Cells vary not only in shape, but also in size, as this example shows. In most organisms, however, even the largest cells are no bigger than the period at the end of this sentence. Why are cells so small?<\/p>\n<div>\n<h1>Explaining Cell Size<\/h1>\n<\/div>\n<p>Most organisms, even very large ones, have microscopic cells. Why don&#8217;t cells get bigger instead of remaining tiny and multiplying? Why aren&#8217;t you one giant cell rolling around school? What limits cell size?<\/p>\n<p>Once you know how a cell functions, the answers to these questions are clear. To carry out life processes, a cell must be able to quickly pass substances in and out of the cell. For example, it must be able to pass\u00a0nutrients\u00a0and oxygen into the cell and waste products out of the cell. Anything that enters or leaves a cell must cross its outer surface. The size of a cell is limited by its need to pass substances across that outer surface.<\/p>\n<p>Look at the three cubes in Figure 4.3.2. A<span style=\"text-align: initial; font-size: 1em;\"> larger cube has less surface area relative to its volume than a smaller cube. This relationship also applies to cells \u2014 a larger cell has less surface area relative to its volume than a smaller cell. A cell with a larger volume also needs more nutrients and oxygen, and produces more waste. Because all of these substances must pass through the surface of the cell, a cell with a large volume will not have enough surface area to allow it to meet its needs. The <\/span><em style=\"text-align: initial; font-size: 1em;\">larger<\/em><span style=\"text-align: initial; font-size: 1em;\"> the cell is, the <\/span><em style=\"text-align: initial; font-size: 1em;\">smaller<\/em><span style=\"text-align: initial; font-size: 1em;\"> its ratio of surface area to volume, and the more difficult it will be for the cell to get rid of its waste and take in necessary substances. This is what limits the size of the cell.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 741px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1570\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Cell-Size-2.png\" alt=\"Image shows three cubes: a small, a medium and a large. The cube with length of 1 has a surface area to volume ratio of 6:1. The cube with a length of 2 has a surface area to volume ratio of 3:1 and the cube with the length of 3 has a surface area to volume ratio of 2:1.\" width=\"741\" height=\"556\" \/><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>Figure 4.3.2 Surface area to volume ratio.<\/em><\/figcaption><\/figure>\n<div>\n<h1>Cell Form and Function<\/h1>\n<\/div>\n<p>Cells with different functions often have varying shapes. The cells pictured below (Figure 4.3.3) are just a few examples of the many different shapes that human cells may have. Each type of cell\u00a0 has characteristics that help it do its job. The job of the nerve cell, for example, is to carry messages to other cells. The nerve cell has many long extensions that reach out in all directions, allowing it to pass messages to many other cells at once. Do you see the tail of each tiny sperm cell? Its tail helps a sperm cell &#8220;swim&#8221; through fluids in the female reproductive tract in order to reach an egg cell. The white blood cell has the job of destroying bacteria and other pathogens. It is a large cell that can engulf foreign invaders.<\/p>\n<div>\n<div id=\"h5p-469\">\n<div class=\"h5p-content\" data-content-id=\"469\"><\/div>\n<\/div>\n<p><em>Figure 4.3.3 Human cells may have many different shapes that help them to do their jobs.<\/em><\/p>\n<\/div>\n<div>\n<h1>Cells With and Without a\u00a0Nucleus<\/h1>\n<\/div>\n<p>The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5797\">nucleus<\/a>\u00a0is a basic\u00a0cell structure\u00a0present in many \u2014 but not\u00a0<em>all \u2014<\/em>\u00a0living cells. The\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5797\">nucleus<\/a>\u00a0of a cell is a structure in the cytoplasm that is surrounded by a membrane (the nuclear membrane) and contains\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_277\">DNA<\/a>. Based on whether or not they have a nucleus, there are two basic types of cells: <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_1572\">prokaryotic<\/a> cells and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_1573\">eukaryotic<\/a> cells.<\/p>\n<h2>Prokaryotic Cells<\/h2>\n<figure id=\"attachment_1574\" aria-describedby=\"caption-attachment-1574\" style=\"width: 392px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1574\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2000px-Average_prokaryote_cell-_en.svg_-2.png\" alt=\"Image shows a diagram of a bacterium. The bacterium is smaller than a typical eukaryotic cell, has fewer organelles and contains no membrane-bound organelles.\" width=\"392\" height=\"319\" \/><figcaption id=\"caption-attachment-1574\" class=\"wp-caption-text\"><em>Figure 4.3.3 Bacteria are prokaryotes, meaning they do not have a nucleus. Their DNA is contained in a region called the nucleoid.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_1572\">Prokaryotic<\/a> cells<\/strong> are cells without a nucleus. The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_277\">DNA<\/a> in prokaryotic cells is in the cytoplasm, rather than enclosed within a nuclear membrane.\u00a0 In addition, these cells are typically smaller than eukaryotic cells and contain fewer organelles.\u00a0 Prokaryotic cells are found in single-celled organisms, such as the bacterium represented by the model in Figure 4.3.3. Organisms with prokaryotic cells are called <strong>prokaryotes<\/strong>. They were the first type of organisms to evolve, and they are still the most common organisms today.<\/p>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Eukaryotic Cells<\/h2>\n<figure id=\"attachment_1577\" aria-describedby=\"caption-attachment-1577\" style=\"width: 2500px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1577\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Animal-Cell-1-2.png\" alt=\"Image shows a diagram of a eukaryotic cell. The cell has many organelles labelled, including: nucleus, nucleolus, rough endoplasmic reticulum, smooth endoplasmic reticulum, Golgi body, vesicles, mitochondria and centrioles.\" width=\"2500\" height=\"1000\" \/><figcaption id=\"caption-attachment-1577\" class=\"wp-caption-text\"><em>Figure 4.3.4 Eukaryotic cells, like this animal cell, contain a nucleus and many other membrane-bound organelles.<\/em><\/figcaption><\/figure>\n<p><strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_1573\">Eukaryotic<\/a> cells<\/strong> are cells that contain a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5797\">nucleus<\/a>. A typical eukaryotic cell is represented by the model in Figure 4.3.4. Eukaryotic cells are usually larger than prokaryotic cells. They are found in some single-celled and all multicellular organisms. Organisms with eukaryotic cells are called <strong>eukaryotes<\/strong>, and they range from\u00a0fungi\u00a0to\u00a0humans.<\/p>\n<p>Besides a nucleus, eukaryotic cells also contain other\u00a0organelles. An\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5557\">organelle<\/a><\/strong>\u00a0is a structure within the cytoplasm that performs a specific job in the cell.\u00a0Organelles\u00a0called\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5783\">mitochondria<\/a>, for example, provide\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5753\">energy<\/a>\u00a0to the cell, and organelles called vesicles store substances in the cell. Organelles allow <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_1573\">eukaryotic<\/a> cells to carry out more functions than <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_1572\">prokaryotic<\/a> cells can.<\/p>\n<p>Interestingly, scientists think that mitochondria were once free-living prokaryotes that infected (or were engulfed by) larger cells. The two organisms developed a symbiotic relationship that was beneficial to both of them, resulting in the smaller prokaryote becoming an organelle within the larger cell. This is called endosymbiotic theory, and it is supported by a lot of evidence, including the fact that <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5783\">mitochondria<\/a> have their own <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_277\">DNA<\/a> separate from the DNA in the nucleus of the eukaryotic cell. Endosymbiotic theory will be described in more detail in later sections, and it&#8217;s also discussed in the video below.<\/p>\n<div>\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"Endosymbiotic Theory\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/FGnS-Xk0ZqU?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p class=\"title style-scope ytd-video-primary-info-renderer\" style=\"text-align: center;\">Endosymbiotic Theory, Amoeba Sisters, 2017.<\/p>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\">4.3 Summary<\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li>Cells must be very small so they have a large enough surface area-to-volume ratio to maintain normal cell processes.<\/li>\n<li>Cells with different functions often have different shapes.<\/li>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_1572\">Prokaryotic<\/a> cells do not have a nucleus. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_1573\">Eukaryotic <\/a>cells\u00a0<em>do<\/em>\u00a0have a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5797\">nucleus<\/a>, along with other\u00a0<a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_5557\">organelles<\/a>.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.3 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>Explain why most cells are very small.<\/li>\n<li>Discuss variations in the form and function of cells.<\/li>\n<li>\n<div id=\"h5p-470\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-470\" class=\"h5p-iframe\" data-content-id=\"470\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Cell Variation\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>\n<div id=\"h5p-471\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-471\" class=\"h5p-iframe\" data-content-id=\"471\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Prokaryote vs. Eukaryote T\/F\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>Do human cells have organelles? Explain your answer.<\/li>\n<li>Which are usually larger \u2013 prokaryotic or eukaryotic cells? What do you think this means for their relative ability to take in needed substances and release wastes? Discuss your answer.<\/li>\n<li>DNA in eukaryotes is enclosed within the _______ \u00a0________.<\/li>\n<li>Name three different types of cells in humans.<\/li>\n<li>Which organelle provides energy in eukaryotic cells?<\/li>\n<li>What is a function of a vesicle in a cell?<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff;\">4.3 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p><iframe loading=\"lazy\" id=\"oembed-2\" title=\"How we think complex cells evolved - Adam Jacobson\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/9i7kAt97XYU?start=1&#38;feature=oembed\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">How we think complex cells evolved &#8211; Adam Jacobson, TED-Ed, 2015.<\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-3\" title=\"Prokaryotic vs. Eukaryotic Cells (Updated)\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/Pxujitlv8wc?feature=oembed&#38;rel=0&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">Prokaryotic vs. Eukaryotic Cells (updated), Amoeba Sisters, 2018.<\/p>\n<\/div>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 4.3.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Borrelia_hermsii_Bacteria_(13758011613).jpg\" rel=\"cc:attributionURL\">Borrelia_hermsii_Bacteria_(13758011613)<\/a> by <a href=\"https:\/\/www.flickr.com\/people\/54591706@N02\">NAID<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.3.2<\/strong><\/p>\n<p>Cell Size by Christine Miller is released into the <a href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"license\">Public Domain<\/a> (https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/).<\/p>\n<p><strong>Figure 4.3.3<\/strong><\/p>\n<ul>\n<li><a style=\"font-size: 1em;\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:BioTek-Wikipedia-Image.tif\">Chondrocyte. BioTek-Wikipedia-Image<\/a><span style=\"font-size: 1em;\"> by BioTek Instruments, Inc. on Wikimedia Commons is used under a <\/span><a style=\"font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en\">CC BY-SA 3.0<\/a><span style=\"font-size: 1em;\"> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\/deed.en) license. <\/span><\/li>\n<li><a style=\"font-size: 1em;\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Neutrophil_with_anthrax_copy.jpg\">Neutrophil with anthrax copy<\/a><span style=\"font-size: 1em;\"> by Volker Brinkmann from <\/span><a style=\"font-size: 1em;\" href=\"https:\/\/journals.plos.org\/plospathogens\/issue?id=10.1371\/issue.ppat.v01.i03\">PLOS Pathogens<\/a><span style=\"font-size: 1em;\"> on Wikimedia Commons is used under a\u00a0<\/span><a style=\"font-size: 1em;\" href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en\">CC BY 2.5<\/a><span style=\"font-size: 1em;\"> (https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en) license.\u00a0<\/span><\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:PLoSBiol4.e126.Fig6fNeuron.jpg\"><em>PLoSBio<\/em>l4.e126.Fig6fNeuron<\/a> by Lee, et al. from <a href=\"https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.0040029\">PLOS Biology<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en\">CC BY 2.5<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.5\/deed.en) license.<\/li>\n<li><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Sperm_(265_33)_human.jpg\">Sperm (265 33) human<\/a> by <a class=\"extiw\" title=\"cs:Josef Reischig\" href=\"https:\/\/cs.wikipedia.org\/wiki\/Josef_Reischig\">Doc. RNDr. Josef Reischig, CSc.<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license.<\/li>\n<\/ul>\n<\/div>\n<p><strong style=\"text-align: initial; font-size: 1em;\"><br \/>\nFigure 4.3.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Average_prokaryote_cell-_en.svg\" rel=\"cc:attributionURL\">Model of a prokaryotic cell: bacterium<\/a> by Mariana Ruiz Villarreal [<a title=\"User:LadyofHats\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:LadyofHats\">LadyofHats]<\/a> on Wikimedia Commons is released into the <a class=\"extiw\" title=\"w:public domain\" href=\"https:\/\/en.wikipedia.org\/wiki\/public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 4.3.5<\/strong><\/p>\n<p>Animal Cell adapted by Christine Miller is used under a <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"license\">CC0 1.0<\/a> (https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en) public domain dedication license. (Original image, <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Animal_Cell_Unannotated.svg\">Animal Cell Unannotated,<\/a> is by <a href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Kelvin13\">Kelvin Song<\/a> on Wikimedia Commons.)<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\">Amoeba Sisters. (2017, May 3). Endosymbiotic theory. YouTube. https:\/\/www.youtube.com\/watch?v=FGnS-Xk0ZqU&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Amoeba Sisters. (2018, July 30). Prokaryotic vs. eukaryotic cells (updated). YouTube. https:\/\/www.youtube.com\/watch?v=Pxujitlv8wc&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">Brinkmann, V. (November 2005). Neutrophil engulfing Bacillus anthracis. <em>PLoS Pathogens 1<\/em> (3): Cover page [digital image]. DOI:10.1371. https:\/\/journals.plos.org\/plospathogens\/issue?id=10.1371\/issue.ppat.v01.i03<\/p>\n<p class=\"hanging-indent\">Lee, W.C.A., Huang, H., Feng, G., Sanes, J.R., Brown, E.N., et al. (2005, December 27) Figure 6f, slightly altered (plus scalebar, minus letter &#8220;f&#8221;.) [digital image]. Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex. <em>PLoS Biology, 4<\/em>(2), e29. doi:10.1371\/journal.pbio.0040029. https:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.0040029<\/p>\n<p class=\"hanging-indent\">TED-Ed. (2015, February 17). How we think complex cells evolved &#8211; Adam Jacobson. https:\/\/www.youtube.com\/watch?v=9i7kAt97XYU&amp;feature=youtu.be<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_4419_5797\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4419_5797\"><div tabindex=\"-1\"><p>A central organelle containing   hereditary material.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4419_277\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4419_277\"><div tabindex=\"-1\"><\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4419_1572\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4419_1572\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1564\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Cliche.jpg\" alt=\"16.5.1 Dog peeing on fire hydrant\" width=\"400\" height=\"300\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>Figure 16.5.1 Just leaving a message.....<\/em><\/figcaption><\/figure>\n<div>\n<h1>Communicating with Urine<\/h1>\n<\/div>\n<p>Why do dogs pee on fire hydrants? Besides \u201chaving to go,\u201d they are marking their territory with chemicals in their urine called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4768\">pheromone<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. It\u2019s a form of communication, in which they are \u201csaying\u201d with odors that the yard is <\/span><em style=\"text-align: initial;font-size: 1em\">theirs<\/em><span style=\"text-align: initial;font-size: 1em\">\u00a0and other dogs should stay away. In addition to fire hydrants, dogs may urinate on fence posts, trees, car tires, and many other objects. Urination in dogs, as in people, is usually a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3004\">voluntary<\/a> process controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2554\">brain<\/a>. The process of forming urine \u2014 which occurs in the kidneys \u2014 occurs constantly, and is not under voluntary control. What happens to all the urine that forms in the kidneys? It passes from the kidneys through the other organs of the urinary system, starting with the ureters.<\/span><\/p>\n<div>\n<h1>Ureters<\/h1>\n<\/div>\n<p>As shown in Figure 16.5.2, <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4725\">ureter<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\"> are tube-like structures that connect the kidneys with the urinary bladder. They are paired structures, with one ureter for each kidney. In adults, ureters are between 25 and 30 cm (about 10\u201312 in) long and about 3 to 4 mm in diameter.<\/span><\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 446px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-1565\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Urinary-System-Male.jpg\" alt=\"16.5.2 Urinary System - Ureters\" width=\"446\" height=\"449\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>16.5.2 Besides the kidneys, the urinary system includes two ureters, the urinary bladder, and the urethra.<\/em><\/figcaption><\/figure>\n<p>Each ureter arises in the pelvis of a kidney (the renal pelvis in Figure 16.5.3). It then passes down the side of the kidney, and finally enters the back of the bladder. At the entrance to the bladder, the ureters have sphincters that prevent the backflow of urine.<\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 388px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-1567\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Adrenal-glands-on-Kidney-by-NCI-Public-Domain-1.jpg\" alt=\"16.5.3 Renal Pelvis and Ureter\" width=\"388\" height=\"357\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>16.5.3 Urine collects in the renal pelvis, which is continuous with the ureter. The ureter then carries the urine from the kidney to the urinary bladder.<\/em><\/figcaption><\/figure>\n<p>The walls of the ureters are composed of multiple layers of different types of tissues.\u00a0 The innermost layer is a special type of epithelium, called transitional epithelium. Unlike the epithelium lining most organs, transitional epithelium is capable of stretching and does not produce mucus. It lines much of the urinary system, including the renal pelvis, bladder, and much of the urethra, in addition to the ureters. Transitional epithelium allows these organs to stretch and expand as they fill with urine or allow urine to pass through. The next layer of the ureter walls is made up of loose connective tissue containing elastic fibres, nerves, and blood and lymphatic vessels. After this layer are two layers of smooth muscles, an inner circular layer, and an outer longitudinal layer. The smooth muscle layers can contract in waves of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2890\">peristalsis<\/a> to propel urine down the ureters from the kidneys to the urinary bladder. The outermost layer of the ureter walls consists of fibrous tissue.<\/p>\n<div>\n<h1>Urinary Bladder<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4731\">urinary bladder<\/a><\/strong>\u00a0is a hollow, muscular, and stretchy organ that rests on the pelvic floor. It collects and stores <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4717\">urine<\/a> from the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2988\">kidney<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0before the urine is eliminated through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4726\">urination<\/a>. As shown in Figure 16.5.4, urine enters the urinary bladder from the ureters through two ureteral openings on either side of the back wall of the bladder. Urine leaves the bladder through a sphincter called the internal urethral sphincter. When the sphincter relaxes and opens, it allows urine to flow out of the bladder and into the urethra.<\/span><\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-1568\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2605_The_Bladder.jpg\" alt=\"16.5.4 Urinary Bladder\" width=\"1024\" height=\"627\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>Figure 16.5.4 This diagram of the urinary bladder shows (a) a cross-sectional drawing of the entire bladder and (b) a microscopic cross-section of the tissues in the wall of the bladder.<\/em><\/figcaption><\/figure>\n<p>Like the ureters, the bladder is lined with transitional epithelium, which can flatten out and stretch as needed as the bladder fills with urine. The next layer (lamina propria) is a layer of loose connective tissue, nerves, and blood and lymphatic vessels. This is followed by a submucosa layer, which connects the lining of the bladder with the detrusor muscle in the walls of the bladder. The outer covering of the bladder is peritoneum, which is a smooth layer of epithelial cells that lines the abdominal cavity and covers most abdominal organs.<\/p>\n<p>The detrusor muscle in the wall of the bladder is made of smooth muscle fibres controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2533\">autonomic<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3014\">somatic<\/a> nervous systems. As the bladder fills, the detrusor muscle automatically relaxes to allow it to hold more urine. When the bladder is about half full, the stretching of the walls triggers the sensation of needing to urinate. When the individual is ready to void, conscious nervous signals cause the detrusor muscle to contract, and the internal urethral sphincter to relax and open. As a result, urine is forcefully expelled out of the bladder and into the urethra.<\/p>\n<div>\n<h1>Urethra<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4732\">urethra<\/a><\/strong> is a tube that connects the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4731\">urinary bladder<\/a> to the external urethral orifice, which is the opening of the urethra on the surface of the body. As shown in Figure 16.5.5, the urethra in males travels through the penis, so it is much longer than the urethra in females. In males, the urethra averages about 20 cm (about 7.8 in) long, whereas in females, it averages only about 4.8 cm (about 1.9 in) long. In males, the urethra carries semen (as well as urine), but in females, it carries only urine.\u00a0 In addition, in males, the urethra passes through the prostate gland (part of the reproductive system) which is absent in women.<\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 512px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-1570\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/512px-Male_and_female_urethral_openings.svg_.png\" alt=\"16.5.5\" width=\"512\" height=\"355\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>Figure 16.5.5 The male pelvis on the left and the female pelvis on the right. Notice how much longer the male urethra is because it travels through the length of the penis to reach the external urethral orifice.<\/em><\/figcaption><\/figure>\n<p>Like the ureters and bladder, the proximal (closer to the bladder) two-thirds of the urethra are lined with transitional epithelium. The distal (farther from the bladder) third of the urethra is lined with mucus-secreting epithelium. The mucus helps protect the epithelium from urine, which is corrosive. Below the epithelium is loose connective tissue, and below that are layers of smooth muscle that are continuous with the muscle layers of the urinary bladder. When the bladder contracts to forcefully expel urine, the smooth muscle of the urethra relaxes to allow the urine to pass through.<\/p>\n<p>In order for urine to leave the body through the external urethral orifice, the external urethral sphincter must relax and open. This sphincter is a striated muscle that is controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3014\">somatic nervous system<\/a>, so it is under conscious, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3004\">voluntary<\/a> control in most people (exceptions are infants, some elderly people, and patients with certain injuries or disorders). The muscle can be held in a contracted state and hold in the urine until the person is ready to urinate. Following urination, the smooth muscle lining the urethra automatically contracts to re-establish muscle tone, and the individual consciously contracts the external urethral sphincter to close the external urethral opening.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4725\">Ureters<\/a>\u00a0are tube-like structures that connect the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2988\">kidneys<\/a>\u00a0with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4731\">urinary bladder<\/a>. Each ureter arises at the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4724\">renal pelvis<\/a> of a kidney and travels down through the abdomen to the urinary bladder. The walls of the ureter contain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2982\">smooth muscle<\/a> that can contract to push <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4717\">urine<\/a> through the ureter by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2890\">peristalsis<\/a>. The walls are lined with transitional epithelium that can expand and stretch.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4731\">urinary bladder<\/a> is a hollow, muscular organ that rests on the pelvic floor. It is also lined with transitional epithelium. The function of the bladder is to collect and store urine from the kidneys before the urine is eliminated through urination. Filling of the bladder triggers the sensation of needing to urinate. When a conscious decision to urinate is made, the detrusor muscle in the bladder wall contracts and forces urine out of the bladder and into the urethra.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4732\">urethra<\/a> is a tube that connects the urinary bladder to the external urethral orifice. Somatic nerves control the sphincter at the distal end of the urethra. This allows the opening of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4627\">sphincter<\/a> for urination to be under <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3004\">voluntary<\/a> control.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What are ureters?\u00a0 Describe the location of the ureters relative to other urinary tract organs.<\/li>\n<li>Identify layers in the walls of a ureter. How do they contribute to the ureter\u2019s function?<\/li>\n<li>Describe the urinary bladder. What is the function of the urinary bladder?<\/li>\n<li>\n<div id=\"h5p-318\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-318\" class=\"h5p-iframe\" data-content-id=\"318\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"16.5 Quiz\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>How does the nervous system control the urinary bladder?<\/li>\n<li>What is the urethra?<\/li>\n<li>How does the nervous system control urination?<\/li>\n<li>Identify the sphincters that are located along the pathway from the ureters to the external urethral orifice.<\/li>\n<li>What are two differences between the male and female urethra?<\/li>\n<li>When the bladder muscle contracts, the smooth muscle in the walls of the urethra _________ .<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/2Brajdazp1o<\/p>\n<p style=\"text-align: center\">The taboo secret to better health | Molly Winter, TED. 2016.<\/p>\n<p>https:\/\/youtu.be\/dg4_deyHLvQ<\/p>\n<p style=\"text-align: center\">What Happens When You Hold Your Pee? SciShow, 2016.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 16.5.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cliche.jpg\" rel=\"cc:attributionURL\">Cliche<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/people\/27735730@N00\" rel=\"nofollow\">Jackie<\/a> on Wikimedia Common s is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\" rel=\"license\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 16.5.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:UrinarySystemMale.jpg\" rel=\"cc:attributionURL\">Urinary System Male<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.5.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Kidney_and_adrenal_gland.jpg\" rel=\"cc:attributionURL\">Adrenal glands on Kidney by NCI Public Domain<\/a>\u00a0by Alan Hoofring (Illustrator) \/<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4355\">photo ID 4355<\/a>) on Wikimedia Commons is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.5.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2605_The_Bladder.jpg\" rel=\"cc:attributionURL\">2605_The_Bladder<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-2-gross-anatomy-of-urine-transport\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license. <span class=\"os-caption\"><span class=\"search-highlight text last\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">(Micrograph originally provided by <span class=\"search-highlight first text last\" data-timestamp=\"1597636975280\" data-highlight-id=\"fda2d69c-8a26-4beb-b12b-daf80f2c011d\" data-highlighted=\"true\">the<\/span>\u00a0Regents of\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975286\" data-highlight-id=\"855d8b77-088b-43c9-81b4-0e0ff4f489e1\" data-highlighted=\"true\">the<\/span> University of Michigan Medical School \u00a9 2012.)<\/span><\/span><\/p>\n<p><strong>Figure 16.5.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Male_and_female_urethral_openings.svg\" rel=\"cc:attributionURL\">512px-Male_and_female_urethral_openings.svg<\/a>\u00a0by <a title=\"User:Andrybak\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Andrybak\">andrybak<\/a> (derivative work) on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\" rel=\"license\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license. (Original: <a title=\"File:Male anatomy blank.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Male_anatomy_blank.svg\">Male anatomy blank.svg<\/a>:\u00a0<a class=\"external text\" href=\"http:\/\/www.luckymojo.com\/faqs\/altsex\/penis.html\" rel=\"nofollow\">alt.sex FAQ<\/a>, derivative work:\u00a0<a title=\"User:Tsaitgaist\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Tsaitgaist\">Tsaitgaist<\/a>\u00a0<a title=\"File:Female anatomy with g-spot.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Female_anatomy_with_g-spot.svg\">Female anatomy with g-spot.svg<\/a>:\u00a0<a title=\"User:Tsaitgaist\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Tsaitgaist\">Tsaitgaist<\/a>.)<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">25.4<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"3366\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">Bladder\u00a0<\/span><\/span><span class=\"os-caption\"><span class=\"search-highlight text last\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">(a) Anterior cross section of the bladder. (b)\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975256\" data-highlight-id=\"b7b616c9-437f-4937-a7f5-c1b47387a77e\" data-highlighted=\"true\">The<\/span>\u00a0detrusor muscle of\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975257\" data-highlight-id=\"31417372-bff6-4d54-941d-580ae31d2bcf\" data-highlighted=\"true\">the bladder<\/span> (source: monkey tissue) LM \u00d7 448 [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 7.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-2-gross-anatomy-of-urine-transport\u00a0<\/span><\/span><\/p>\n<p class=\"hanging-indent\">SciShow. (2016, January 22). What happens when you hold your pee? YouTube. https:\/\/www.youtube.com\/watch?v=dg4_deyHLvQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED. (2016, September 2). The taboo secret to better health | Molly Winter. YouTube. https:\/\/www.youtube.com\/watch?v=2Brajdazp1o&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4419_1573\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4419_1573\"><div tabindex=\"-1\"><p>Created by CK-12 Foundation\/Adapted by Christine Miller<\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img class=\"wp-image-1564\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2019\/06\/Cliche.jpg\" alt=\"16.5.1 Dog peeing on fire hydrant\" width=\"400\" height=\"300\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>Figure 16.5.1 Just leaving a message.....<\/em><\/figcaption><\/figure>\n<div>\n<h1>Communicating with Urine<\/h1>\n<\/div>\n<p>Why do dogs pee on fire hydrants? Besides \u201chaving to go,\u201d they are marking their territory with chemicals in their urine called <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4768\">pheromone<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">. It\u2019s a form of communication, in which they are \u201csaying\u201d with odors that the yard is <\/span><em style=\"text-align: initial;font-size: 1em\">theirs<\/em><span style=\"text-align: initial;font-size: 1em\">\u00a0and other dogs should stay away. In addition to fire hydrants, dogs may urinate on fence posts, trees, car tires, and many other objects. Urination in dogs, as in people, is usually a <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3004\">voluntary<\/a> process controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2986\">brain<\/a>. The process of forming urine \u2014 which occurs in the kidneys \u2014 occurs constantly, and is not under voluntary control. What happens to all the urine that forms in the kidneys? It passes from the kidneys through the other organs of the urinary system, starting with the ureters.<\/span><\/p>\n<div>\n<h1>Ureters<\/h1>\n<\/div>\n<p>As shown in Figure 16.5.2, <strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4725\">ureter<\/strong><strong style=\"font-size: 1em\">s<\/strong><strong style=\"text-align: initial;font-size: 1em\"><\/a><\/strong><span style=\"text-align: initial;font-size: 1em\"> are tube-like structures that connect the kidneys with the urinary bladder. They are paired structures, with one ureter for each kidney. In adults, ureters are between 25 and 30 cm (about 10\u201312 in) long and about 3 to 4 mm in diameter.<\/span><\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 446px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-1565\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Urinary-System-Male.jpg\" alt=\"16.5.2 Urinary System - Ureters\" width=\"446\" height=\"449\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>16.5.2 Besides the kidneys, the urinary system includes two ureters, the urinary bladder, and the urethra.<\/em><\/figcaption><\/figure>\n<p>Each ureter arises in the pelvis of a kidney (the renal pelvis in Figure 16.5.3). It then passes down the side of the kidney, and finally enters the back of the bladder. At the entrance to the bladder, the ureters have sphincters that prevent the backflow of urine.<\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 388px\" class=\"wp-caption aligncenter\"><img class=\" wp-image-1567\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/Adrenal-glands-on-Kidney-by-NCI-Public-Domain-1.jpg\" alt=\"16.5.3 Renal Pelvis and Ureter\" width=\"388\" height=\"357\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>16.5.3 Urine collects in the renal pelvis, which is continuous with the ureter. The ureter then carries the urine from the kidney to the urinary bladder.<\/em><\/figcaption><\/figure>\n<p>The walls of the ureters are composed of multiple layers of different types of tissues.\u00a0 The innermost layer is a special type of epithelium, called transitional epithelium. Unlike the epithelium lining most organs, transitional epithelium is capable of stretching and does not produce mucus. It lines much of the urinary system, including the renal pelvis, bladder, and much of the urethra, in addition to the ureters. Transitional epithelium allows these organs to stretch and expand as they fill with urine or allow urine to pass through. The next layer of the ureter walls is made up of loose connective tissue containing elastic fibres, nerves, and blood and lymphatic vessels. After this layer are two layers of smooth muscles, an inner circular layer, and an outer longitudinal layer. The smooth muscle layers can contract in waves of <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2890\">peristalsis<\/a> to propel urine down the ureters from the kidneys to the urinary bladder. The outermost layer of the ureter walls consists of fibrous tissue.<\/p>\n<div>\n<h1>Urinary Bladder<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4731\">urinary bladder<\/a><\/strong>\u00a0is a hollow, muscular, and stretchy organ that rests on the pelvic floor. It collects and stores <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4717\">urine<\/a> from the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2988\">kidney<span style=\"font-size: 1em\">s<\/span><span style=\"text-align: initial;font-size: 1em\"><\/a><\/span><span style=\"text-align: initial;font-size: 1em\">\u00a0before the urine is eliminated through <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4726\">urination<\/a>. As shown in Figure 16.5.4, urine enters the urinary bladder from the ureters through two ureteral openings on either side of the back wall of the bladder. Urine leaves the bladder through a sphincter called the internal urethral sphincter. When the sphincter relaxes and opens, it allows urine to flow out of the bladder and into the urethra.<\/span><\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-1568\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/2605_The_Bladder.jpg\" alt=\"16.5.4 Urinary Bladder\" width=\"1024\" height=\"627\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>Figure 16.5.4 This diagram of the urinary bladder shows (a) a cross-sectional drawing of the entire bladder and (b) a microscopic cross-section of the tissues in the wall of the bladder.<\/em><\/figcaption><\/figure>\n<p>Like the ureters, the bladder is lined with transitional epithelium, which can flatten out and stretch as needed as the bladder fills with urine. The next layer (lamina propria) is a layer of loose connective tissue, nerves, and blood and lymphatic vessels. This is followed by a submucosa layer, which connects the lining of the bladder with the detrusor muscle in the walls of the bladder. The outer covering of the bladder is peritoneum, which is a smooth layer of epithelial cells that lines the abdominal cavity and covers most abdominal organs.<\/p>\n<p>The detrusor muscle in the wall of the bladder is made of smooth muscle fibres controlled by both the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2940\">autonomic<\/a> and <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3014\">somatic<\/a> nervous systems. As the bladder fills, the detrusor muscle automatically relaxes to allow it to hold more urine. When the bladder is about half full, the stretching of the walls triggers the sensation of needing to urinate. When the individual is ready to void, conscious nervous signals cause the detrusor muscle to contract, and the internal urethral sphincter to relax and open. As a result, urine is forcefully expelled out of the bladder and into the urethra.<\/p>\n<div>\n<h1>Urethra<\/h1>\n<\/div>\n<p>The\u00a0<strong><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4732\">urethra<\/a><\/strong> is a tube that connects the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4731\">urinary bladder<\/a> to the external urethral orifice, which is the opening of the urethra on the surface of the body. As shown in Figure 16.5.5, the urethra in males travels through the penis, so it is much longer than the urethra in females. In males, the urethra averages about 20 cm (about 7.8 in) long, whereas in females, it averages only about 4.8 cm (about 1.9 in) long. In males, the urethra carries semen (as well as urine), but in females, it carries only urine.\u00a0 In addition, in males, the urethra passes through the prostate gland (part of the reproductive system) which is absent in women.<\/p>\n<figure id=\"attachment_1570\" aria-describedby=\"caption-attachment-1570\" style=\"width: 512px\" class=\"wp-caption aligncenter\"><img class=\"size-full wp-image-1570\" src=\"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-content\/uploads\/sites\/152\/2023\/10\/512px-Male_and_female_urethral_openings.svg_.png\" alt=\"16.5.5\" width=\"512\" height=\"355\"><figcaption id=\"caption-attachment-1570\" class=\"wp-caption-text\"><em>Figure 16.5.5 The male pelvis on the left and the female pelvis on the right. Notice how much longer the male urethra is because it travels through the length of the penis to reach the external urethral orifice.<\/em><\/figcaption><\/figure>\n<p>Like the ureters and bladder, the proximal (closer to the bladder) two-thirds of the urethra are lined with transitional epithelium. The distal (farther from the bladder) third of the urethra is lined with mucus-secreting epithelium. The mucus helps protect the epithelium from urine, which is corrosive. Below the epithelium is loose connective tissue, and below that are layers of smooth muscle that are continuous with the muscle layers of the urinary bladder. When the bladder contracts to forcefully expel urine, the smooth muscle of the urethra relaxes to allow the urine to pass through.<\/p>\n<p>In order for urine to leave the body through the external urethral orifice, the external urethral sphincter must relax and open. This sphincter is a striated muscle that is controlled by the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3014\">somatic nervous system<\/a>, so it is under conscious, <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3004\">voluntary<\/a> control in most people (exceptions are infants, some elderly people, and patients with certain injuries or disorders). The muscle can be held in a contracted state and hold in the urine until the person is ready to urinate. Following urination, the smooth muscle lining the urethra automatically contracts to re-establish muscle tone, and the individual consciously contracts the external urethral sphincter to close the external urethral opening.<\/p>\n<div>\n<div class=\"textbox textbox--key-takeaways\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Summary<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ul>\n<li><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4725\">Ureters<\/a>\u00a0are tube-like structures that connect the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2988\">kidneys<\/a>\u00a0with the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4731\">urinary bladder<\/a>. Each ureter arises at the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4724\">renal pelvis<\/a> of a kidney and travels down through the abdomen to the urinary bladder. The walls of the ureter contain <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2982\">smooth muscle<\/a> that can contract to push <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4717\">urine<\/a> through the ureter by <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_2890\">peristalsis<\/a>. The walls are lined with transitional epithelium that can expand and stretch.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4731\">urinary bladder<\/a> is a hollow, muscular organ that rests on the pelvic floor. It is also lined with transitional epithelium. The function of the bladder is to collect and store urine from the kidneys before the urine is eliminated through urination. Filling of the bladder triggers the sensation of needing to urinate. When a conscious decision to urinate is made, the detrusor muscle in the bladder wall contracts and forces urine out of the bladder and into the urethra.<\/li>\n<li>The <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4732\">urethra<\/a> is a tube that connects the urinary bladder to the external urethral orifice. Somatic nerves control the sphincter at the distal end of the urethra. This allows the opening of the <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_4627\">sphincter<\/a> for urination to be under <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_4419_3004\">voluntary<\/a> control.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--exercises\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Review Questions<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<ol>\n<li>What are ureters?\u00a0 Describe the location of the ureters relative to other urinary tract organs.<\/li>\n<li>Identify layers in the walls of a ureter. How do they contribute to the ureter\u2019s function?<\/li>\n<li>Describe the urinary bladder. What is the function of the urinary bladder?<\/li>\n<li>\n<div id=\"h5p-196\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-196\" class=\"h5p-iframe\" data-content-id=\"196\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Energy Needs of Living Things\"><\/iframe><\/div>\n<\/div>\n<\/li>\n<li>How does the nervous system control the urinary bladder?<\/li>\n<li>What is the urethra?<\/li>\n<li>How does the nervous system control urination?<\/li>\n<li>Identify the sphincters that are located along the pathway from the ureters to the external urethral orifice.<\/li>\n<li>What are two differences between the male and female urethra?<\/li>\n<li>When the bladder muscle contracts, the smooth muscle in the walls of the urethra _________ .<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<h1 class=\"textbox__title\"><span style=\"color: #ffffff\">16.5 Explore More<\/span><\/h1>\n<\/header>\n<div class=\"textbox__content\">\n<p>https:\/\/youtu.be\/2Brajdazp1o<\/p>\n<p style=\"text-align: center\">The taboo secret to better health | Molly Winter, TED. 2016.<\/p>\n<p>https:\/\/youtu.be\/dg4_deyHLvQ<\/p>\n<p style=\"text-align: center\">What Happens When You Hold Your Pee? SciShow, 2016.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>Attributions<\/h2>\n<p><strong>Figure 16.5.1<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Cliche.jpg\" rel=\"cc:attributionURL\">Cliche<\/a> by <a class=\"external text\" href=\"https:\/\/www.flickr.com\/people\/27735730@N00\" rel=\"nofollow\">Jackie<\/a> on Wikimedia Common s is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\" rel=\"license\">CC BY 2.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/2.0) license.<\/p>\n<p><strong>Figure 16.5.2<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:UrinarySystemMale.jpg\" rel=\"cc:attributionURL\">Urinary System Male<\/a> by <a title=\"User:BruceBlaus\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:BruceBlaus\">BruceBlaus<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\" rel=\"license\">CC BY-SA 4.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0) license.<\/p>\n<p><strong>Figure 16.5.3<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Kidney_and_adrenal_gland.jpg\" rel=\"cc:attributionURL\">Adrenal glands on Kidney by NCI Public Domain<\/a>\u00a0by Alan Hoofring (Illustrator) \/<a class=\"extiw\" title=\"en:National Cancer Institute\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Cancer_Institute\">National Cancer Institute<\/a> (<a href=\"https:\/\/visualsonline.cancer.gov\/details.cfm?imageid=4355\">photo ID 4355<\/a>) on Wikimedia Commons is in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Public_domain\">public domain<\/a> (https:\/\/en.wikipedia.org\/wiki\/Public_domain).<\/p>\n<p><strong>Figure 16.5.4<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:2605_The_Bladder.jpg\" rel=\"cc:attributionURL\">2605_The_Bladder<\/a> by <a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-2-gross-anatomy-of-urine-transport\">OpenStax College<\/a> on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\" rel=\"license\">CC BY 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by\/3.0) license. <span class=\"os-caption\"><span class=\"search-highlight text last\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">(Micrograph originally provided by <span class=\"search-highlight first text last\" data-timestamp=\"1597636975280\" data-highlight-id=\"fda2d69c-8a26-4beb-b12b-daf80f2c011d\" data-highlighted=\"true\">the<\/span>\u00a0Regents of\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975286\" data-highlight-id=\"855d8b77-088b-43c9-81b4-0e0ff4f489e1\" data-highlighted=\"true\">the<\/span> University of Michigan Medical School \u00a9 2012.)<\/span><\/span><\/p>\n<p><strong>Figure 16.5.5<\/strong><\/p>\n<p><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Male_and_female_urethral_openings.svg\" rel=\"cc:attributionURL\">512px-Male_and_female_urethral_openings.svg<\/a>\u00a0by <a title=\"User:Andrybak\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Andrybak\">andrybak<\/a> (derivative work) on Wikimedia Commons is used under a <a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/3.0\" rel=\"license\">CC BY-SA 3.0<\/a> (https:\/\/creativecommons.org\/licenses\/by-sa\/3.0) license. (Original: <a title=\"File:Male anatomy blank.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Male_anatomy_blank.svg\">Male anatomy blank.svg<\/a>:\u00a0<a class=\"external text\" href=\"http:\/\/www.luckymojo.com\/faqs\/altsex\/penis.html\" rel=\"nofollow\">alt.sex FAQ<\/a>, derivative work:\u00a0<a title=\"User:Tsaitgaist\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Tsaitgaist\">Tsaitgaist<\/a>\u00a0<a title=\"File:Female anatomy with g-spot.svg\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Female_anatomy_with_g-spot.svg\">Female anatomy with g-spot.svg<\/a>:\u00a0<a title=\"User:Tsaitgaist\" href=\"https:\/\/commons.wikimedia.org\/wiki\/User:Tsaitgaist\">Tsaitgaist<\/a>.)<\/p>\n<h2>References<\/h2>\n<p class=\"hanging-indent\"><span class=\"os-title-label\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2013, June 19). Figure\u00a0<\/span><\/span><span class=\"os-number\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">25.4<\/span><\/span><span class=\"os-divider\">\u00a0<\/span><span id=\"3366\" class=\"os-title\" data-type=\"title\"><span class=\"search-highlight text\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">Bladder\u00a0<\/span><\/span><span class=\"os-caption\"><span class=\"search-highlight text last\" data-timestamp=\"1597636975236\" data-highlight-id=\"b46f272f-e324-486a-9b46-6607817bb903\" data-highlighted=\"true\">(a) Anterior cross section of the bladder. (b)\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975256\" data-highlight-id=\"b7b616c9-437f-4937-a7f5-c1b47387a77e\" data-highlighted=\"true\">The<\/span>\u00a0detrusor muscle of\u00a0<span class=\"search-highlight first text last\" data-timestamp=\"1597636975257\" data-highlight-id=\"31417372-bff6-4d54-941d-580ae31d2bcf\" data-highlighted=\"true\">the bladder<\/span> (source: monkey tissue) LM \u00d7 448 [digital image].\u00a0 In <em>Anatomy and Physiology<\/em> (Section 7.3). OpenStax. https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/25-2-gross-anatomy-of-urine-transport\u00a0<\/span><\/span><\/p>\n<p class=\"hanging-indent\">SciShow. (2016, January 22). What happens when you hold your pee? YouTube. https:\/\/www.youtube.com\/watch?v=dg4_deyHLvQ&amp;feature=youtu.be<\/p>\n<p class=\"hanging-indent\">TED. (2016, September 2). The taboo secret to better health | Molly Winter. YouTube. https:\/\/www.youtube.com\/watch?v=2Brajdazp1o&amp;feature=youtu.be<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4419_5557\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4419_5557\"><div tabindex=\"-1\"><p>A tiny cellular structure that performs specific functions within a cell.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4419_5783\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4419_5783\"><div tabindex=\"-1\"><p>A double-membrane-bound organelle found in most eukaryotic organisms. Mitochondria convert oxygen and nutrients into adenosine triphosphate (ATP). ATP is the chemical energy \"currency\" of the cell that powers the cell's metabolic activities.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_4419_5753\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_4419_5753\"><div tabindex=\"-1\"><p>The ability to do work.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"author":32,"menu_order":3,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":"cc-by-nc"},"chapter-type":[48],"contributor":[],"license":[55],"class_list":["post-4419","chapter","type-chapter","status-publish","hentry","chapter-type-numberless","license-cc-by-nc"],"part":4404,"_links":{"self":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/users\/32"}],"version-history":[{"count":4,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4419\/revisions"}],"predecessor-version":[{"id":6380,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4419\/revisions\/6380"}],"part":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/parts\/4404"}],"metadata":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapters\/4419\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/media?parent=4419"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/pressbooks\/v2\/chapter-type?post=4419"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/contributor?post=4419"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.ccconline.org\/acchumanbio\/wp-json\/wp\/v2\/license?post=4419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}